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Conserved domains on  [gi|79321503|ref|NP_001031303|]
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Major facilitator superfamily protein [Arabidopsis thaliana]

Protein Classification

sugar porter family MFS transporter( domain architecture ID 13022761)

sugar porter family major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of sugar or polyol substrates such as glucose, galactose, trehalose, and quinate

CATH:  1.20.1250.20
SCOP:  3000310
TCDB:  2.A.1.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
60-429 8.95e-91

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 279.46  E-value: 8.95e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  60 VASLTSLLFGYHLGVVNETLESISIDLGFSGNTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASV 139
Cdd:cd17315   1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 140 SASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNL-GWWRICFWI 218
Cdd:cd17315  81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPpGWWRLMFAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 219 STVPAAMLAVFMELCVESPQWLFkrgraAEAEAVFEKLLGGSYVKAAMAELVKSDRGDDADSAkLSELLFGRSFRGSTVA 298
Cdd:cd17315 161 AAVPALLQLLLMFFLPESRALLV-----GVGLQLLQQLTGINAVMYYAPTIFKSAGGGTASIL-ASIIVGVVNLLATLVA 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 299 VVLMDKLGRKVLLIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLRATAL 378
Cdd:cd17315 235 IRLVDKVGRRPLLLIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGM 314
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 79321503 379 AVCLAVHWVINFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVE 429
Cdd:cd17315 315 AIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLALVFVFFFVPE 365
 
Name Accession Description Interval E-value
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
60-429 8.95e-91

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 279.46  E-value: 8.95e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  60 VASLTSLLFGYHLGVVNETLESISIDLGFSGNTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASV 139
Cdd:cd17315   1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 140 SASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNL-GWWRICFWI 218
Cdd:cd17315  81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPpGWWRLMFAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 219 STVPAAMLAVFMELCVESPQWLFkrgraAEAEAVFEKLLGGSYVKAAMAELVKSDRGDDADSAkLSELLFGRSFRGSTVA 298
Cdd:cd17315 161 AAVPALLQLLLMFFLPESRALLV-----GVGLQLLQQLTGINAVMYYAPTIFKSAGGGTASIL-ASIIVGVVNLLATLVA 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 299 VVLMDKLGRKVLLIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLRATAL 378
Cdd:cd17315 235 IRLVDKVGRRPLLLIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGM 314
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 79321503 379 AVCLAVHWVINFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVE 429
Cdd:cd17315 315 AIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLALVFVFFFVPE 365
Sugar_tr pfam00083
Sugar (and other) transporter;
58-439 4.92e-59

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 199.81  E-value: 4.92e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503    58 VLVASLTSLLFGYHLGVVNETLESISIDLGFSGNT---------IAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQL 128
Cdd:pfam00083   2 ALVAALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKsvsslaalsVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   129 SALPMIVGASVSASTESLMG---MLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIG-LLGSLFAGIP 204
Cdd:pfam00083  82 ANVLFVIGAVLQGAAKGKWSvyqLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGiLLAYIFGLGL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   205 AK-DNLGWWRICFWISTVPAAMLAVFMELCVESPQWLFKRGRAAEAEAVFEKLLGGSYVKAAMAELVKS-DRGDDADSAK 282
Cdd:pfam00083 162 NKtSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELDEIKDSlEAGQEAEKAS 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   283 LSELLFGRSFR--------------------------------------------------GSTVAVVLMDKLGRKVLLI 312
Cdd:pfam00083 242 WKELFSTKTRRqrlligvmlqifqqltginaifyysttifenlglsdsflvtiivgvvnfvFTFIAIFLVDRFGRRPLLL 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   313 GSFAGMAVS---LGLQAIAYTSLPSPFGtlFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLRATALAVCLAVHWVIN 389
Cdd:pfam00083 322 LGAAGMAICfviLGIVALLGVSKSDWAG--IVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLAN 399
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 79321503   390 FFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVETKGKSLQEIE 439
Cdd:pfam00083 400 FLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEID 449
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
59-438 1.79e-53

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 186.01  E-value: 1.79e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503    59 LVASLTSLLFGYHLGVVNETLESISIDLGFSGNTIAE------GLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALP 132
Cdd:TIGR00879  31 LIAAIGGLMFGYDTGVIGGALALPAFEFKFTSANSDSyssslwGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALL 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   133 MIVGA--SVSASTESLMGML-LGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAK--D 207
Cdd:TIGR00879 111 FVIGAilMGLAAFALSVEMLiVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGKVslN 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   208 NLGWWRICFWISTVPAAMLAVFMELCVESPQWLFKRGRAAEAEAVFEKLLGGSYVKA---AMAELVKSDRGDDADSAKLS 284
Cdd:TIGR00879 191 NTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKellDELELIDIKRSIEKRSVQPS 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   285 EL--------LFGRSFRG-----------------------------------------------STVAVVLMDKLGRKV 309
Cdd:TIGR00879 271 WGslfsstrrIRRRLFLGvvlqwfqqftginaimyysptifenagvstdhaflvsiivgavnfafTFVAIFLVDRFGRRP 350
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   310 LLIGSFAGMAVSLGLQAIAYTSL--PSPFGTLFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLRATALAVCLAVHWV 387
Cdd:TIGR00879 351 LLLIGAAGMAICLFVLGILGASFvtGSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWL 430
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 79321503   388 INFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVETKGKSLQEI 438
Cdd:TIGR00879 431 ANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
xylE PRK10077
D-xylose transporter XylE; Provisional
58-439 1.83e-51

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 180.66  E-value: 1.83e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   58 VLVASLTSLLFGYHLGVVNETLESI------SIDLGFSGNTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSAL 131
Cdd:PRK10077  14 TLVATLGGLLFGYDTAVISGTVESLntvfvaPQNLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  132 PMIVGASVSASTESLMGML------------LGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSL 199
Cdd:PRK10077  94 LFFISALGSAWPEFGFTSIgpdntgyvpefvIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVY 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  200 FA--GIPAKDNLGW-----WRICFWISTVPAAMLAVFMELCVESPQWLFKRGRAAEAEAVFEKLLGGSYVKAAMAELVKS 272
Cdd:PRK10077 174 FVnyFIARSGDASWlntdgWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLATQALQEIKHS 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  273 DRGDDADSAKLseLLFG---------------------------RSFRG----------------------STVAVVLMD 303
Cdd:PRK10077 254 LDHGRKTGGKL--LMFGvgvivigvmlsvfqqfvginvvlyyapEIFKTlgastdiallqtiivgvinltfTVLAIMTVD 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  304 KLGRKVLLIGSFAGMAVS-LGLQAIAYTSLPSpfgtlFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLRATALAVCL 382
Cdd:PRK10077 332 KFGRKPLQIIGALGMAIGmFSLGTAFYTQAPG-----IVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRGKALAIAV 406
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 79321503  383 AVHWVINFFVGLLFLRM------LEQLGSVLLNAIFGFFCVVAVIFVQKNVVETKGKSLQEIE 439
Cdd:PRK10077 407 AAQWIANYFVSWTFPMMdknswlVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEME 469
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
58-387 5.91e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 93.50  E-value: 5.91e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  58 VLVASLTSLLFGYHLGVVNETLESISIDLGFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGA 137
Cdd:COG2814  12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA--GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 138 SVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNLGwWRICFW 217
Cdd:COG2814  90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 218 ISTVPAAMLAVFMELCV-ESPQWLFKRGRAAEAEAVFEKLLGGSYVKAA------------MAELVKSDRGDDADSAKLS 284
Cdd:COG2814 169 VNAVLALLALLLLLRLLpESRPAARARLRGSLRELLRRPRLLLLLLLAFllgfgffalftyLPLYLQEVLGLSASAAGLL 248
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 285 ELLFG-RSFRGSTVAVVLMDKLGRKVLLIGSFAGMAVSLGLQAIAytslpspfGTLFLSVGGMLLFVLSFAtGAGPVPSL 363
Cdd:COG2814 249 LALFGlGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA--------GSLWLLLLALFLLGFGFG-LLFPLLQA 319
                       330       340
                ....*....|....*....|....
gi 79321503 364 LLSEICPGRLRATALAVCLAVHWV 387
Cdd:COG2814 320 LVAELAPPEARGRASGLYNSAFFL 343
 
Name Accession Description Interval E-value
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
60-429 8.95e-91

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 279.46  E-value: 8.95e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  60 VASLTSLLFGYHLGVVNETLESISIDLGFSGNTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASV 139
Cdd:cd17315   1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 140 SASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNL-GWWRICFWI 218
Cdd:cd17315  81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPpGWWRLMFAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 219 STVPAAMLAVFMELCVESPQWLFkrgraAEAEAVFEKLLGGSYVKAAMAELVKSDRGDDADSAkLSELLFGRSFRGSTVA 298
Cdd:cd17315 161 AAVPALLQLLLMFFLPESRALLV-----GVGLQLLQQLTGINAVMYYAPTIFKSAGGGTASIL-ASIIVGVVNLLATLVA 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 299 VVLMDKLGRKVLLIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLRATAL 378
Cdd:cd17315 235 IRLVDKVGRRPLLLIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGM 314
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 79321503 379 AVCLAVHWVINFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVE 429
Cdd:cd17315 315 AIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLALVFVFFFVPE 365
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
59-429 2.39e-64

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 212.04  E-value: 2.39e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  59 LVASLTSLLFGYHLGVVNETLESISIDLGFSGNTiaEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGAS 138
Cdd:cd17359   4 LVAALGGLLFGYDTGVINGALPFLQTDFNLTPFL--EGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISAL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 139 VSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGS-----LFAGIPAKDNLGW-- 211
Cdd:cd17359  82 GSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAyivnyLIANAGGADWLGAeg 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 212 WRICFWISTVPAAMLAVFMELCVESPQWLFKRGR----AAEAEAVFEKLLGgsyVKAAM--AELVKSDRGDDADSAKLSE 285
Cdd:cd17359 162 WRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGKpiliIGIGLAIFQQFVG---INVIFyyGPEIFQNAGFSENAALLQT 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 286 LLFGR-SFRGSTVAVVLMDKLGRKVLLIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLSVGGMLLFVLSFATGAGPVPSLL 364
Cdd:cd17359 239 IGIGVvNVIFTIIAILLVDKVGRKPLLLIGSIGMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPVTWVL 318
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 79321503 365 LSEICPGRLRATALAVCLAVHWVINFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVE 429
Cdd:cd17359 319 LSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAAFGLAFTFLIFAVICVLAFLFVWKFVPE 383
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
60-438 8.08e-60

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 200.27  E-value: 8.08e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  60 VASLTSLLFGYHLGVVNETLESISIDL-----GFSGNTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMI 134
Cdd:cd17362   1 FPALGGLLFGYDIGATSGALLSITSPAlsgtdWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 135 VGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNLGWWRI 214
Cdd:cd17362  81 VGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 215 CFWISTVPAAMLAVFMELCVESPQW---LFKRGRAAEAEAVFEKLLGGSYVKAAMAELVKSDRGDDADSAKLSELLFGRS 291
Cdd:cd17362 161 MYGLAAPPALLLGIGMWFLPPSPRWqgnYRKPLIIGLGLVLFQQITGQPSVLYYAATIFKSAGFSAASDATLVSVGLGVF 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 292 FRGST-VAVVLMDKLGRKVLLIGSFAGMAVSLGLQAIAYTSLP-SPFGTLFLSVGGMLLFVLSFATGAGPVPSLLLSEIC 369
Cdd:cd17362 241 KLLMTiVAVLLVDKLGRRPLLLGGVSGMVVSLFLLAAYNLFVQmGPAGLAWLSLVALLLYVGAYQISFGPISWLMVSEIF 320
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 79321503 370 PGRLRATALAVCLAVHWVINFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVETKGKSLQEI 438
Cdd:cd17362 321 PLRVRGRAIALAVLVNFGSNALVSLAFLPLQELIGLPGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
Sugar_tr pfam00083
Sugar (and other) transporter;
58-439 4.92e-59

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 199.81  E-value: 4.92e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503    58 VLVASLTSLLFGYHLGVVNETLESISIDLGFSGNT---------IAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQL 128
Cdd:pfam00083   2 ALVAALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKsvsslaalsVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   129 SALPMIVGASVSASTESLMG---MLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIG-LLGSLFAGIP 204
Cdd:pfam00083  82 ANVLFVIGAVLQGAAKGKWSvyqLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGiLLAYIFGLGL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   205 AK-DNLGWWRICFWISTVPAAMLAVFMELCVESPQWLFKRGRAAEAEAVFEKLLGGSYVKAAMAELVKS-DRGDDADSAK 282
Cdd:pfam00083 162 NKtSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELDEIKDSlEAGQEAEKAS 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   283 LSELLFGRSFR--------------------------------------------------GSTVAVVLMDKLGRKVLLI 312
Cdd:pfam00083 242 WKELFSTKTRRqrlligvmlqifqqltginaifyysttifenlglsdsflvtiivgvvnfvFTFIAIFLVDRFGRRPLLL 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   313 GSFAGMAVS---LGLQAIAYTSLPSPFGtlFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLRATALAVCLAVHWVIN 389
Cdd:pfam00083 322 LGAAGMAICfviLGIVALLGVSKSDWAG--IVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLAN 399
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 79321503   390 FFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVETKGKSLQEIE 439
Cdd:pfam00083 400 FLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEID 449
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
59-438 1.79e-53

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 186.01  E-value: 1.79e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503    59 LVASLTSLLFGYHLGVVNETLESISIDLGFSGNTIAE------GLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALP 132
Cdd:TIGR00879  31 LIAAIGGLMFGYDTGVIGGALALPAFEFKFTSANSDSyssslwGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALL 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   133 MIVGA--SVSASTESLMGML-LGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAK--D 207
Cdd:TIGR00879 111 FVIGAilMGLAAFALSVEMLiVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGKVslN 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   208 NLGWWRICFWISTVPAAMLAVFMELCVESPQWLFKRGRAAEAEAVFEKLLGGSYVKA---AMAELVKSDRGDDADSAKLS 284
Cdd:TIGR00879 191 NTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKellDELELIDIKRSIEKRSVQPS 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   285 EL--------LFGRSFRG-----------------------------------------------STVAVVLMDKLGRKV 309
Cdd:TIGR00879 271 WGslfsstrrIRRRLFLGvvlqwfqqftginaimyysptifenagvstdhaflvsiivgavnfafTFVAIFLVDRFGRRP 350
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   310 LLIGSFAGMAVSLGLQAIAYTSL--PSPFGTLFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLRATALAVCLAVHWV 387
Cdd:TIGR00879 351 LLLIGAAGMAICLFVLGILGASFvtGSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWL 430
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 79321503   388 INFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVETKGKSLQEI 438
Cdd:TIGR00879 431 ANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
xylE PRK10077
D-xylose transporter XylE; Provisional
58-439 1.83e-51

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 180.66  E-value: 1.83e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   58 VLVASLTSLLFGYHLGVVNETLESI------SIDLGFSGNTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSAL 131
Cdd:PRK10077  14 TLVATLGGLLFGYDTAVISGTVESLntvfvaPQNLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  132 PMIVGASVSASTESLMGML------------LGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSL 199
Cdd:PRK10077  94 LFFISALGSAWPEFGFTSIgpdntgyvpefvIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVY 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  200 FA--GIPAKDNLGW-----WRICFWISTVPAAMLAVFMELCVESPQWLFKRGRAAEAEAVFEKLLGGSYVKAAMAELVKS 272
Cdd:PRK10077 174 FVnyFIARSGDASWlntdgWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLATQALQEIKHS 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  273 DRGDDADSAKLseLLFG---------------------------RSFRG----------------------STVAVVLMD 303
Cdd:PRK10077 254 LDHGRKTGGKL--LMFGvgvivigvmlsvfqqfvginvvlyyapEIFKTlgastdiallqtiivgvinltfTVLAIMTVD 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  304 KLGRKVLLIGSFAGMAVS-LGLQAIAYTSLPSpfgtlFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLRATALAVCL 382
Cdd:PRK10077 332 KFGRKPLQIIGALGMAIGmFSLGTAFYTQAPG-----IVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRGKALAIAV 406
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 79321503  383 AVHWVINFFVGLLFLRM------LEQLGSVLLNAIFGFFCVVAVIFVQKNVVETKGKSLQEIE 439
Cdd:PRK10077 407 AAQWIANYFVSWTFPMMdknswlVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEME 469
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
58-437 4.46e-50

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 175.84  E-value: 4.46e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  58 VLVASLTSLLFGYHLGVVNETLESISIDLGFSGN-TIAEGLVVSTCLG-GAFIGSLFSGLVADGVGRRRAFQLSALPMIV 135
Cdd:cd17358   4 TFVANLGSFSFGIAVGWSSPALPSLMSDNSLSLPlTVAQFSWFGSLLTlGALIGALLSGKLADRIGRKRTLLISAIPCIL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 136 GASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGipakdNLGWWRIC 215
Cdd:cd17358  84 GWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLG-----SFLPWRTL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 216 FWISTVPAAMLAVFMELCVESPQWLFKRGRAAEAEAVFEKLLGGSY-----VKAAMAELVKSDRgdDADSAKLSELLFGR 290
Cdd:cd17358 159 ALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDAdiskeAAEIQEELAELEK--EAKESSFSDLFQRK 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 291 SFR--------------------------------------------------GSTVAVVLMDKLGRKVLLIGSFAGMAV 320
Cdd:cd17358 237 YLKplviglglmlfqqlsginavifyassifdeagsgldpntatiiigvvqvvGTLVATLLVDRLGRRPLLLVSAIGMGI 316
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 321 SLGLQAIAYT---SLPSPFGTLFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLRATALAVCLAVHWVINFFVGLLFL 397
Cdd:cd17358 317 GLLALGLYFYlqeHGALLSSVSWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFP 396
                       410       420       430       440
                ....*....|....*....|....*....|....*....|
gi 79321503 398 RMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVETKGKSLQE 437
Cdd:cd17358 397 FLTLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
60-423 2.76e-48

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 168.99  E-value: 2.76e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  60 VASLTSLLFGYHLGVVNETLESISIDLG-FSGNTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGAS 138
Cdd:cd17360   1 FAGIGGFLFGYDTGVISGALLYIKDDLGeVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 139 VSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIG-LLGSLFAGIPAKDNLGwWRICFW 217
Cdd:cd17360  81 VMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGqFVAYVINGAFSYLPGG-WRWMLG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 218 ISTVPAAMLAVFMELCVESPQW--LFKRGRAAEAEAVFEKLLGGSYVKAAMAELVK-SDRGDDADSAKLSELLFGRSFRG 294
Cdd:cd17360 160 LAAVPAVLQFIGLLFLPESPRWpsTRRALIVGCGLQAFQQFSGINTVMYYSATILQmAGFKDNQNAIWLSLIVAGTNFIF 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 295 STVAVVLMDKLGRKVLLIGSFAGMAVSLGLQAIaytslpspfgtlFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLR 374
Cdd:cd17360 240 TIVGMYLIDKFGRRKLLLISLFGVIVALVVLAV------------WLALVGLILYLAFFAPGMGPVPWTVNSEIYPLWAR 307
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....
gi 79321503 375 ATALAVCLAVHWVINFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFV 423
Cdd:cd17360 308 GTGGGCAAAVNWVFNLLVSQTFLTLTQAIGPYGTFLLFAGLAVLGLIFI 356
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
58-433 1.09e-47

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 169.75  E-value: 1.09e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  58 VLVASLTSLLFGYHLGVVN-----------ETLESI-SIDLGFSGNTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRA 125
Cdd:cd17357   2 VIVAFGGSFQFGYNIGVVNapqevfkefinDTLVDRyGLNLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 126 FQLSALPMIVGA---SVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIG-LLGSLFA 201
Cdd:cd17357  82 LLISNALLVVSSllmFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGiLLGQVFG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 202 --GIPAKDNLgwWRICFWISTVPAAMLAVFMELCVESPQWLF-KRGRAAEAEAVFEKLLGGSY-VKAAMAELVKSDRGDD 277
Cdd:cd17357 162 lpSVLGTETL--WPYLLFFPGIPALLQLAALPFFPESPKFLLiSKGDEEEAEKSLKFLRGIEDdVDQELEEIKKESEQMG 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 278 ADSA-KLSELL----------------FGRSFRGST------------------------------------VAVVLMDK 304
Cdd:cd17357 240 DQKQvSLMQLLrdpslrlplllvlvvsASQQFSGINaiffystfifenagfspqlaewanlgigivnvlstiVGPFLIEK 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 305 LGRKVLLIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLRATALAVCLAV 384
Cdd:cd17357 320 VGRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSV 399
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*....
gi 79321503 385 HWVINFFVGLLFLrMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVETKGK 433
Cdd:cd17357 400 NWTSNFIVGMAFP-PLQSIGGGFVFIIFAIPCALFLLYLYRYLPETKGR 447
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
59-439 7.34e-44

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 158.18  E-value: 7.34e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  59 LVASLTSLLFGYHLGVVNETL------ESISIDLGFSGNTIA-EGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSAL 131
Cdd:cd17356   4 AFVSLGGFLFGYDTGSISGILnmksfqKYFADNTGTYYPSSSrQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCV 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 132 PMIVGASVS-ASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNLG 210
Cdd:cd17356  84 IYIIGAIIQvAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLDG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 211 --WWRICFWISTVPAAMLAVFMELCVESPQWLfKRGRAAEAEAVFEKLLGGSYVKAAMAELVKSDRGDDADSAKLSELLF 288
Cdd:cd17356 164 saQWRIPLGLQIVWGLLLLIGMFFLPESPRWL-YRTILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGSSPLLTSIILY 242
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 289 GRSFRGSTVAVVLMDKLGRKVLLIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLS----VGGML----LFVLSFATGAGPV 360
Cdd:cd17356 243 IVNFVSTIPGLFFVDKFGRRTCLLIGAAGMSICLFIYAAVGVRYLIPNPQSGTSnksaGNGMIvficLFIFSFATTWGPI 322
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 79321503 361 PSLLLSEICPGRLRATALAVCLAVHWVINFFVGLLFLRMLEQLGSVLLnAIFGFFCVVAVIFVQKNVVETKGKSLQEIE 439
Cdd:cd17356 323 AWVYVAEVFPLRVRSKGMALATAFNWLWNFLISFFTPFIIGSIGFKYY-YIFAGCNLLAFIVVFFFVPETKGLTLEEID 400
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
58-433 6.33e-41

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 151.33  E-value: 6.33e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  58 VLVASLTSLLFGYHLGVVN---ETLESISID--LGFSGNTIAEGLV-------VSTCLGGAFIGSLFSGLVADGVGRRRA 125
Cdd:cd17431   3 VFVAVLGSLQFGYNTGVINapqKVIEEFYNKtlGDRYGEPISPETLttlwslsVAIFSVGGMIGSFSVGLFVNRFGRRNS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 126 FQLSALPMIVGA---SVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAG 202
Cdd:cd17431  83 MLYNNLLAFAGAalmGLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQIFG 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 203 IP---AKDNLgwWRICFWISTVPAAMLAVFMELCVESPQWLF-KRGRAAEAEAVFEKLLGGSYVKAAMAELVKSDRGDDA 278
Cdd:cd17431 163 LEfilGTEEL--WPLLLGFTIVPAILQLALLPFCPESPRYLLiNRNEEEEAKSVLKKLRGTTDVSEDIQEMKEESRQMMR 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 279 DS-AKLSELLFGRSFRG-----------------------ST---------------------------VAVVLMDKLGR 307
Cdd:cd17431 241 EKkVTILELFRSSSYRQpiiiaivlqlsqqlsginavfyySTsifekagvqqpvyatigagvvntiftvVSLFLVERAGR 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 308 KVLLIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLRATALAVCLAVHWV 387
Cdd:cd17431 321 RTLHLIGLGGMAICAILMTIALLLLEGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWT 400
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*..
gi 79321503 388 INFFVGLLFLRMLEQLGS-VLLnaIFGFFCVVAVIFVQKNVVETKGK 433
Cdd:cd17431 401 SNFIVGMCFQYIANLCGPyVFI--IFTVFLLTFFIFTYFKVPETKGK 445
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
58-438 7.45e-41

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 151.23  E-value: 7.45e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  58 VLVASL-TSLLFGYHLGVV-----------NET-LESISIDLGFSGNTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRR 124
Cdd:cd17432   2 TLAAAFgSSFQYGYNLSVVnsptpyiqnfyNETwTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRKG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 125 AFQLSALPMIVGA---SVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFA 201
Cdd:cd17432  82 TLLLNNIFAIVAAilmGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 202 GIPAKdnLG---WWRICFWISTVPAAMLAVFMELCVESPQW-LFKRGRAAEAEAVFEKLLGGSYVKAAMAELVKSDRGDD 277
Cdd:cd17432 162 GLREL--LGneeGWPLLLALTGVPALLQLLTLPFFPESPRYlLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEK 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 278 ADSAK-LSELLFGRSFR----------------------------------------------------GSTVAVVLMDK 304
Cdd:cd17432 240 GVGTVsVLELFRDRSVRwqlisiivlmagqqlcginaiyfyadsifleagipedkiqyvtvgtgacevlATITCVLVIER 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 305 LGRKVLLIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLRATALAVCLAV 384
Cdd:cd17432 320 LGRRPLLIGGFGLMAVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAFMVAGSL 399
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....
gi 79321503 385 HWVINFFVGLLFLRMLEQLGSVLLnAIFGFFCVVAVIFVQKNVVETKGKSLQEI 438
Cdd:cd17432 400 NWLSNFLVGLLFPFIQEGLGAYCF-LVFAVICLLTAIYIFFVLPETKGKTFLEI 452
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
58-438 5.99e-38

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 141.86  E-value: 5.99e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  58 VLVASLTSLLFGYHLGVVNETLESISIDLGFSGNTiaEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGA 137
Cdd:cd17435   3 SVTAAVSGLLVGYELGIISGALLQLRTLLALSCHE--QEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 138 SVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGS-----LFAGIPAKdnlgwW 212
Cdd:cd17435  81 LLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAyisnyAFANVSNG-----W 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 213 RICFWISTVPAAMLAVFMELCVESPQWLF------KRGRAAEAEAVFEKLLGGSYVKAAMAELVKSDRGDDADSAKLSEL 286
Cdd:cd17435 156 KYMFGLVIPLAALQAIAMYFLPPSPRFLVmkdnmrARLLIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLAST 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 287 LFGRSFRGSTV-AVVLMDKLGRKVLLIGSFAGMAVSLGLQAiaytslpspfgtLFLSVGGMLLFVLSFATGAGPVPSLLL 365
Cdd:cd17435 236 GVGVVKVVSTIpAIFLVDKVGSKTFLCIGSSVMAVSLVTMG------------LWLSLASLLVYVAAFSIGLGPMPWLVL 303
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 79321503 366 SEICPGRLRATALAVCLAVHWVINFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVETKGKSLQEI 438
Cdd:cd17435 304 SEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTELIGLPWVCFIYTAMSLASLVFVIMFVPETKGCSLEQI 376
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
60-438 2.99e-37

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 140.23  E-value: 2.99e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  60 VASLTSLLFGYHLGVVNETLESISIDLGFsgNTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASV 139
Cdd:cd17437   1 LASLNSILLGYDIGVMSGAVIFIKEDLKI--SDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 140 SASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLL-----GSLFAGIPAKDNlgwWRI 214
Cdd:cd17437  79 MGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILlgyvsNYAFSGLPLHVG---WRL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 215 CFWISTVPAAMLAVFMELCVESPQWLFKRGR---AAEAEAVFEKLLGGSYVKAAMAELVKSDRGDDADSAKLSELLFGRS 291
Cdd:cd17437 156 MLGVGAVPSLFLAIGVLAMPESPRWTPAVRRmliAALGIHFFQQASGIDAVVLYSPRIFKKAGIKSKDKLLLATVAVGVT 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 292 FRGST-VAVVLMDKLGRKVLLIGSFAGMAVSLGLQAIAYTSLPSPFGT----LFLSVGGMLLFVLSFATGAGPVPSLLLS 366
Cdd:cd17437 236 KTLFIlVATFLLDKVGRRPLLLTSTGGMTLSLTALATSLTFIDRNGGGltwaLVLAITAVCSFVAFFSIGAGPITWVYSS 315
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 79321503 367 EICPGRLRATALAVCLAVHWVINFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVETKGKSLQEI 438
Cdd:cd17437 316 EIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAITTGGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
105-437 2.11e-36

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 138.47  E-value: 2.11e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 105 GAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYG 184
Cdd:cd17433  53 GAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLG 132
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 185 SSTQIATCIGLLGSLFAGIPAKdnlgwWRICFWISTVPAAMLAVFMELCVESPQWLFKRGRAAEAEAVFEKLLG---GSY 261
Cdd:cd17433 133 SCVQLMVVIGIMGAYLAGLVLD-----WRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGpdqGWE 207
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 262 VKAAMAELVKSDRGDDADSAKLSE------------LLFGRSFRG----------------------------------S 295
Cdd:cd17433 208 WECIGIEQSFHLEEQSFSLALLKQpgiykpliigvsLMAFQQLTGinavmfyaetifeeakfkdssvasvivaaiqvlfT 287
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 296 TVAVVLMDKLGRKVLLIGSFAGMAVSlglqaiaytslPSPFGtlFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLRA 375
Cdd:cd17433 288 AVAALIMDRAGRKVLLVLSGVVMVFS-----------TAAFG--WLAVGSMGFFIAGFAVGWGPIPWLVMSEIFPLHVRG 354
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 79321503 376 TALAVCLAVHWVINFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVETKGKSLQE 437
Cdd:cd17433 355 VASGICVLTNWLMAFLVTKEFSSLMEVLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLEQ 416
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
60-438 8.09e-30

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 119.52  E-value: 8.09e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  60 VASLTSLLFGYHLGVVNETLESISIDLGFSgnTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASV 139
Cdd:cd17436   5 VSLLGGLTFGYELGIISGALLQLQTDFSLS--CFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 140 SASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNLGWWRICFWIS 219
Cdd:cd17436  83 LTLAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNVLTGWRYMFGLA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 220 TVPAAMLAVFMELCVESPQWLFKRGRAAEAEAV------FEKLLGGSYVKAAMAELVKSDRGDDADSAKLSELLFGRSFR 293
Cdd:cd17436 163 IIPAAIQFASILLLPKKPEVLNIKDNMRRRTLVglglvlFQQFTGQPNVLCYASTIFRSVGFQSNSSAVLASVGLGVVKV 242
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 294 GST-VAVVLMDKLGRKVLLIGSFAGMAVSLGLQAIAYTSLpspfgtlflsvgGMLLFVLSFATGAGPVPSLLLSEICPGR 372
Cdd:cd17436 243 IATlLAMLFADRAGRRSLLIAGCSVMAVSVSGIGLWITLL------------CLMAFVSAFSIGFGPMTWLVLSEIYPAD 310
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 79321503 373 LRATALAVCLAVHWVINFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVETKGKSLQEI 438
Cdd:cd17436 311 IRGRAFSFCNSFNWAANLLITLSFLDLIDVIGLSWTFLLYGVVGVAGVVFIYLFVPETKGQSLEEI 376
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
97-423 7.72e-27

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 111.19  E-value: 7.72e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  97 LVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSP 176
Cdd:cd17361  55 LFTSSLYLAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAP 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 177 AYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNLGW-WRICFWISTVPAAMLAVFMELCVESPQwlFKRGRAAEAEAVFEK 255
Cdd:cd17361 135 AKLRGALNIGFQLAITIGILIANLINYGTSKIKPNgWRLSLGLAAVPALILLLGSLFLPETPN--SPQLVIAILIPFFQQ 212
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 256 LLGgsyVKAAM--AELVKSDRGDDADSAKLSELLFGRSFRGST-VAVVLMDKLGRKVLLIGSFAGMAVSLGLQAIAYTSL 332
Cdd:cd17361 213 LTG---INVIMfyAPVLFQTLGFGSDASLISAVITGAVNVVSTlVSIYLVDRFGRRFLLLEGGVQMLASQVAIGILLAVK 289
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 333 PSPFGTLFLSVGG-----MLLFVLSFATGAGPVPSLLLSEICPGRLRATALAVCLAVHWVINFFVGLLFLRMLEQLGSVL 407
Cdd:cd17361 290 FGDGGELPKAYAIavvvlICLYVAAFAWSWGPLGWLVPSEIFPLETRSAGQSLTVAVNFLFTFVIAQAFLSMLCAMKFGI 369
                       330
                ....*....|....*.
gi 79321503 408 LnAIFGFFCVVAVIFV 423
Cdd:cd17361 370 F-LFFAGWVVVMSLFV 384
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
105-437 3.95e-25

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 106.84  E-value: 3.95e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 105 GAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYG 184
Cdd:cd17434  53 GAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALG 132
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 185 SSTQIATCIGLLGSLFAGIpakdnLGWWRICFWISTVPAAMLAVFMELCVESPQWLFKRGRAAEAEAVFEKLLGGSYVKA 264
Cdd:cd17434 133 ACPQIMAVFGSLALYALGL-----LLPWRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALAWLRGPNTDYM 207
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 265 AMAELVKSDRGDDADSAKLSELLFGRSFRGSTVAVV-------------------------------------------- 300
Cdd:cd17434 208 TEFEQIKDNIRKQSSRLSWAELKTPSYYKPILIAVVmrflqqltgitpilvylepifhltavilepkydaalvgavrlls 287
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 301 ------LMDKLGRKVLLIgsfagmaVSLGLQAIAYTSLpspfgTLFLSVGGMLlFVLSFATGAGPVPSLLLSEICPGRLR 374
Cdd:cd17434 288 vaiaasLMDKAGRKILLF-------TSAFLMFAANLSM-----GLIPLIAAML-FIMGYAMGWGPITWLLMSEILPLKAR 354
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 79321503 375 ATALAVCLAVHWVINFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVETKGKSLQE 437
Cdd:cd17434 355 GVASGLCVVVSWITAFVLTQLFLPVVVTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTLEQ 417
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
58-423 5.22e-24

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 102.29  E-value: 5.22e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  58 VLVASLTSLLFGYHLGVVNETLESISIDLGFSGNTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGA 137
Cdd:cd17316   1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 138 SVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGI----PAKDNLGwWR 213
Cdd:cd17316  81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASllipLLSGDWG-WR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 214 ICFWISTVPAAM---------LAVFMELCVESPQWLFkrgraaeaeavfekllggsyvKAAMAELVKSDRGDDADSAKLS 284
Cdd:cd17316 160 ILFLIGALPALLalllrrrtlLLILLWFFISFGYYGL---------------------TTFLPTYLQTVLGLSPATSSLY 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 285 ELLFGRSFR-GSTVAVVLMDKLGRKVLLIGSFAGMAVSLglqAIAYTSLPSPFGTLFLsVGGMLLFVLSFATGAGPVpsl 363
Cdd:cd17316 219 LLLISLGALvGALIAGLLSDRIGRKKTLVIGLILSGILA---LPLFYLLSGSPTLLLL-LLFILSFFVGGVWGALYA--- 291
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 364 LLSEICPGRLRATALAVCLAVHWVINFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFV 423
Cdd:cd17316 292 YLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
58-387 5.91e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 93.50  E-value: 5.91e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  58 VLVASLTSLLFGYHLGVVNETLESISIDLGFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGA 137
Cdd:COG2814  12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA--GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 138 SVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNLGwWRICFW 217
Cdd:COG2814  90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 218 ISTVPAAMLAVFMELCV-ESPQWLFKRGRAAEAEAVFEKLLGGSYVKAA------------MAELVKSDRGDDADSAKLS 284
Cdd:COG2814 169 VNAVLALLALLLLLRLLpESRPAARARLRGSLRELLRRPRLLLLLLLAFllgfgffalftyLPLYLQEVLGLSASAAGLL 248
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 285 ELLFG-RSFRGSTVAVVLMDKLGRKVLLIGSFAGMAVSLGLQAIAytslpspfGTLFLSVGGMLLFVLSFAtGAGPVPSL 363
Cdd:COG2814 249 LALFGlGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA--------GSLWLLLLALFLLGFGFG-LLFPLLQA 319
                       330       340
                ....*....|....*....|....
gi 79321503 364 LLSEICPGRLRATALAVCLAVHWV 387
Cdd:COG2814 320 LVAELAPPEARGRASGLYNSAFFL 343
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
61-423 6.57e-16

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 79.01  E-value: 6.57e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  61 ASLTSLLFGYHLGVVNETLESISIDLGFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVS 140
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQL--GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 141 ASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIG-LLGSLFAGIPAKDNLGWWRICFWIS 219
Cdd:cd06174  79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGgILGPLLGGILASSLGFGWRAVFLIA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 220 TVPAAMLAVFMELCVESPQWLFKRGRAAEAEAVFEKLL--------------------GGSYVKAAMAELVKSDRG--DD 277
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLkrvlknpglwllllaiflvnLAYYSFSTLLPLFLLDLGglSV 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 278 ADSAKLSELLFGRSFRGSTVAVVLMDK-LGRKVLLIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLSVGGMLLFVLSFAtg 356
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA-- 316
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 79321503 357 agpvpslLLSEICPGRLRATALAVCLAVHWVINFFVGLLFLRMLEQLGSvlLNAIFGFFCVVAVIFV 423
Cdd:cd06174 317 -------LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG--LTGAFLVLAVLLLLAA 374
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
58-423 8.08e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 78.37  E-value: 8.08e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  58 VLVASLTSLLFGYHLGVVNETLESISIDLGFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGA 137
Cdd:COG2271  12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQL--GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 138 SVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNLGwWRICFW 217
Cdd:COG2271  90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAAFL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 218 ISTVPAAMLAVFMELCVespqWLFKRGRAAEAEAVFekLLGGSYVKAAMAElvksdrgDDADSAKLSELLFGRSFRGSTV 297
Cdd:COG2271 169 ILGLPGLLLALLRFWLL----ALAYFLVYFALYGFL--TWLPTYLVEVRGL-------SLAQAGLLLSLPFLAGIVGSLL 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 298 AVVLMDKLGR--KVLLIGSFAGMAVSLGLQAIaytslpspFGTLFLSVGGMLLFVLSFATGAGPVPSlLLSEICPGRLRA 375
Cdd:COG2271 236 GGWLSDRLGRrrKLVLAIGLLLAALALLLLAL--------LPSPALAIALLFLAGFGLGGAFGLLWA-LAAELFPKKARG 306
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 79321503 376 TALAVCLAVHWVINFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFV 423
Cdd:COG2271 307 TASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
85-423 1.12e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 78.38  E-value: 1.12e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  85 DLGFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGP 164
Cdd:COG2223  34 EFGLSAAQL--GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSF 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 165 SVTALYVTEVSPAYVRGTYgssTQIATCIGLLGSLFAGIPAKDNLGW--WRICFWISTVPAAMLAVFMELCVESPQWLFK 242
Cdd:COG2223 112 AVGIALVSKWFPPDRRGLA---LGLAAGGGNLGAAVAAFLAPLLIAAfgWRNAFLILGILLLVVAVLAWLFLRDPPAGAA 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 243 RGRAAEAEAVFEKL----------------LGGSYVKAAMAELVKSDRGDDADSAKLseLLFGRSFRGSTVAVV---LMD 303
Cdd:COG2223 189 AAAKASLRDQLEALrdprfwllsllyfgtfGSFIGFSSWLPPYLVDQFGLSAATAGL--LAALFALLGALGRPLggwLSD 266
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 304 KLGRKVLLIGSFAGMAVSLGLqaiaytsLPSPFGTLFLSVGGMLLFVLSFATGAGPVPSlLLSEICPGRLRATALAVCLA 383
Cdd:COG2223 267 RIGGRRVLLIVFALMALGLLL-------LALALGSLWLFLVLFLLLGLALGGGNGAVFA-LVPDIFPTKNAGAVYGLVGA 338
                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 79321503 384 VHWVINFFVGLLFLRMLEQLGS-VLLNAIFGFFCVVAVIFV 423
Cdd:COG2223 339 AGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALVLT 379
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
96-422 7.74e-15

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 75.80  E-value: 7.74e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  96 GLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVS 175
Cdd:cd17371  37 GLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYV 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 176 PAYVRGTYGSSTQIATCIG-LLGSLFAGIPAKDNLGW--WRICFWISTVPAAMLAVFMELCVESPQWLFKRGRAAEAE-- 250
Cdd:cd17371 117 PARHRGKALGYVQSGWAVGwLLATLLAALLFPLLPPEiaWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFAdr 196
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 251 ----AVFEK---------------LLGGSY-VKAAMAELVKSDRG-DDADSAKLSELLFGRSFRGSTVAVVLMDKLGRKV 309
Cdd:cd17371 197 pslrELFSPpllrttllasllatgALGGYYgITTWLPSYLTGERGlSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRN 276
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 310 LLIGSFAGMAVSLglqaIAYTSLPSPFgTLFLSVGGMLLFvlsFATGAGPVPSLLLSEICPGRLRATALAVCLAVHWVIN 389
Cdd:cd17371 277 NFALFALGSAISI----LLYFFLPLSP-TLILILGFPLGF---FASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIG 348
                       330       340       350
                ....*....|....*....|....*....|....*..
gi 79321503 390 ----FFVGLLFLRMLEQLGSVLLnAIFGFFCVVAVIF 422
Cdd:cd17371 349 alfpFLVGFLATSGSLGTAIAVF-AAVYYIAGLVLAL 384
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
50-363 8.57e-15

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 74.46  E-value: 8.57e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  50 SWKRSLPHVLVASLTSLLFGYHLGVVNETLESISIDLGFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLS 129
Cdd:COG0477   8 PTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL--GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 130 ALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIG-LLGSLFAGIPAkdN 208
Cdd:COG0477  86 LLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGlALGPLLGGLLV--A 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 209 LGWWRICFWISTVPAAMLAVFMELCVESPQWLFKRGRAAEAEAVFekllggsyvkaamaelvksdrgdDADSAKLSELLF 288
Cdd:COG0477 164 ALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLL-----------------------AALALALLALLL 220
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 79321503 289 GRSFRGSTVAVVLMDKLGRKVLLIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLSVGGMLLFVLSFATGAGPVPSL 363
Cdd:COG0477 221 LLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
58-252 2.17e-12

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 68.15  E-value: 2.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503    58 VLVASLTSLLFGYHLGVVNETLESISIDLGFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGA 137
Cdd:TIGR00895  19 IILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQL--GFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFT 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   138 SVSASTESLMGMLLGRFLVGIGMG-IGPSVTALyVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNLGwWRICF 216
Cdd:TIGR00895  97 LLCALATNVTQLLILRFLAGLGLGgLMPNLNAL-VSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG-WRSLF 174
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 79321503   217 WISTV-PAAMLAVFMELCVESPQWLFKRGRAAEAEAV 252
Cdd:TIGR00895 175 YVGGIaPLLLLLLLMRFLPESIDFLVSKRPETVRRIV 211
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
58-384 4.40e-12

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 67.23  E-value: 4.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  58 VLVASLTSLLFGYHLGVVNETLESISIDLGFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGA 137
Cdd:cd17365   1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQL--GPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFT 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 138 SVSASTESLMGMLLGRFLVGIGMG-IGPSVTALyVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNLGwWRICF 216
Cdd:cd17365  79 LLTAFAQSVLQLALLRFLTGLGLGaAMPNAITL-VSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-WRSVF 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 217 WISTVPAAMLAVFMelcvespqwlfkRGRAAEAEAVFEKLLGGSYVKAAMAELVKSDRGDDADSAKLSELLFGRSFRGST 296
Cdd:cd17365 157 LLGGVPPLILLPLL------------RGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSL 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 297 VAVVLMDKLGRKVLLIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLSvgGMllfvlsFATGAGPVPSLLLSEICPGRLRAT 376
Cdd:cd17365 225 LLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLA--GA------CVNGAQVGLYALAARFYPTEVRAT 296

                ....*...
gi 79321503 377 ALAVCLAV 384
Cdd:cd17365 297 GVGWALGV 304
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
58-421 8.26e-12

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 66.53  E-value: 8.26e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  58 VLVASLTSLLFGYHLGVVNETLESISIDLGFSGNTIA---EGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMI 134
Cdd:cd17364   1 IIIAGMGFFTDAYDLFSISLVTKILGRLYYGGKGSLPsgvSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 135 VGA-----SVSASTESLMGML-LGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTY--------------GSSTQIATCIG 194
Cdd:cd17364  81 IGTilsalSPGSTPLGVMGWLiFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALiaavfamqgfgilaGAIVTLILSAI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 195 LLGSLFAGIPAKDNLGwWRICFWISTVPAAMLAVF-MELCVESPQWlFKRGRAAEAEAVFEK----LLGGSYVKAAMAEL 269
Cdd:cd17364 161 FEHPLPAGTYHHADLV-WRIVLGLGAIPALSVLYFrKHLLGTAGTW-FLLDIAFYGQNLFQStiisAIGFSKTMNAYQEL 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 270 VKSDRGDDadsakLSELLFGrsFRGSTVAVVLMDKLGRKVLLIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLSVGGMLLF 349
Cdd:cd17364 239 FNIAVGQL-----IIALAGT--VPGYWFTVFLIDRIGRKKIQMMGFFGMTIFLLILAGPYDHWKISTIGFFVLYGLTFFF 311
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 79321503 350 vlsFATGAGPVPSLLLSEICPGRLRATALAVCLAVHWVINFFVGLLFLRMLEQLGsvlLNAIFGFFCVVAVI 421
Cdd:cd17364 312 ---SNFGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIG---VRNVLIILAGVALL 377
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
105-437 2.23e-11

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 65.42  E-value: 2.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   105 GAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGM-GIGPSVTALYvTEVSPAYVRGTY 183
Cdd:TIGR00898 139 GVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIgGIWVQAVVLN-TEFLPKKQRAIV 217
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   184 GSSTQIATCIGLLgsLFAGIpAKDNLGWWRICFWIS--TVPAAMLAVFMElcvESPQWLFKRGRAAEAEAVFEKLLGGSY 261
Cdd:TIGR00898 218 GTLIQVFFSLGLV--LLPLV-AYFIPDWRWLQLAVSlpTFLFFLLSWFVP---ESPRWLISQGRIEEALKILQRIAKING 291
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   262 VKAAMAELVKS---DRGDDADSAKLSELLFGRSFRGST------------------------------------------ 296
Cdd:TIGR00898 292 KKLPAEVLSLSlekDLSSSKKQYSFLDLFRTPNLRKTTlclmmlwfttafsyyglvldlgnlggniyldlfisglvelpa 371
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   297 --VAVVLMDKLGRKVLLIGSFAGMAVSLGLQAIAytslpsPFGTLFLSVGGMLLFVlSFATGAGPVPSLLLSEICPGRLR 374
Cdd:TIGR00898 372 klITLLLIDRLGRRYTMAASLLLAGVALLLLLFV------PVDLYFLRTALAVLGK-FGITSAFQMVYLYTAELYPTVVR 444
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 79321503   375 ATALAVC--LAVhwvinffVGLLFLRMLEQLGSV---LLNAIFGFFCVVAVIFVQkNVVETKGKSLQE 437
Cdd:TIGR00898 445 NLGVGVCstMAR-------VGSIISPFLVYLGEKwlfLPLVLFGGLALLAGILTL-FLPETKGVPLPE 504
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
79-424 1.32e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 62.57  E-value: 1.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  79 LESISIDLGFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGI 158
Cdd:cd17324  22 LPDIARDFGVSVAQA--GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGL 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 159 GMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNLGwWRICFWISTVPAAMLAVFM-------- 230
Cdd:cd17324 100 AHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAIAVLALLAALLLwrllpslp 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 231 -----ELCVESPQWLFKRGRAAEAEAVFEKLLGGSYVKA--AMAELVKSDRGDDADSAKLSELLFG-RSFRGSTVAVVLM 302
Cdd:cd17324 179 pkkpgSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALytYLAPFLTDVPGFSSSAIIGLLLLFGvAGVVGSPLAGRLA 258
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 303 DKLGRKVLLIGSFAGMAVSLGLQAIAytslpspfGTLFLSVGGMLLFVLSFATGAGPVPSLLLSeiCPGRLRATALAVCL 382
Cdd:cd17324 259 DRGGRRALLIALLLLAAALLLLTLLG--------PSPLLLLVGLVLWGLGFFAAHSALQTRVLR--LAPEARGLASSLYL 328
                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 79321503 383 AVHWVINFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQ 424
Cdd:cd17324 329 AAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
108-384 6.67e-09

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 57.38  E-value: 6.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 108 IGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESL--------MGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYV 179
Cdd:cd17368  55 IGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYatigiaapLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGR 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 180 RGTYGS----STQIATCIG-LLG-SLFAGIPAKDNLGW-WRICFWISTVPAAmLAVFMELCVESPQWLFKRGRAAEAEAV 252
Cdd:cd17368 135 RGFYTSwqsaSQQVAIVAGaLVGyLLSLTLTAEALAEWgWRIPFFIGLLIIP-LGLWLRRSLEETEAFLERKARPTRREL 213
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 253 FEKLLG-GSYVKAAMAELV-----------------KSDRGDDADSAKLSELLFGRS-FRGSTVAVVLMDKLGRKVLLIG 313
Cdd:cd17368 214 FALLANnRRIILLGMLLVAgstvtfyfttvytptyaKTVLGLSARDSFLVTLLAGVAnFIWAPLGGALSDRIGRRPVLLV 293
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 79321503 314 SFAGMAVSLGLQAIAYTSLPSPFGTLflsvGGMLLFVLSFATGAGPVPsLLLSEICPGRLRATALAVCLAV 384
Cdd:cd17368 294 ITLAALVTLYPVFAWLTAAPSFGRLL----LVLLVLSFFFGMYGGAMV-VALVELFPVRVRSTGFSLVYAL 359
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
96-344 9.39e-09

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 57.17  E-value: 9.39e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  96 GLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVS 175
Cdd:COG0738  46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG 125
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 176 PAYvRGTYGSSTQIATCIG-LLGSLFAGIPAKDNLG-WWRICFWISTVPAAMLAVFMeLCVESPQWLFKRGRAAEAEAVF 253
Cdd:COG0738 126 PET-AASRLNLLHAFFSLGaLLGPLLGGLLILLGLSlSWHLPYLILAVLLLLLALLF-LRSKLPEIEEEEEEAAGSAASL 203
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 254 EKLLGGSYVKAA-----------------MAELVKSDRGDDADSAKLSELLF------GRsfrgsTVAVVLMDKLGRKVL 310
Cdd:COG0738 204 KSLLKNPRLLLGglaiflyvgaegaigdwLPLYLKDVLGLSEATAALGLSLFwggmtiGR-----FLGGFLLKRFGPVRL 278
                       250       260       270
                ....*....|....*....|....*....|....
gi 79321503 311 LIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLSVG 344
Cdd:COG0738 279 LRLSALLAAVGLLLALLAPGPWLALIGLALVGLG 312
MFS_1 pfam07690
Major Facilitator Superfamily;
82-380 1.13e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 56.66  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503    82 ISIDLGFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMG 161
Cdd:pfam07690  23 LAEDLGISPTEI--GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAG 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   162 IGPSVTALYVTEVSPAYVRGTYGSSTQIATCIG-LLGSLFAGIPAKdnLGWWRICFWISTVPAAMLAVFMELCVESPQWL 240
Cdd:pfam07690 101 ALFPAALALIADWFPPEERGRALGLVSAGFGLGaALGPLLGGLLAS--LFGWRAAFLILAILSLLAAVLLLLPRPPPESK 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   241 FKRGRAAEAEAVFE-----------KLLGGSYVKAAMAELVKSDRGDDADSAKLSELLFGRSFR-GSTVAVVLMDKLGRK 308
Cdd:pfam07690 179 RPKPAEEARLSLIVawkallrdpvlWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGlGGLLGAIGRLLLGRL 258
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 79321503   309 VLLIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLSVGGMLLFVLSFATGAGPVPSL-LLSEICPGRLRATALAV 380
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNaLVSDLAPKEERGTASGL 331
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
108-384 6.34e-08

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 54.61  E-value: 6.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 108 IGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESL--------MGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYV 179
Cdd:cd17367  55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYatigiwapIILLLARLLQGLSVGGEYGTSATYLSEVAPPGR 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 180 RGTYGSSTQIATCIGLLGSLFAGIPAKDNLG------W-WRICFWISTVpAAMLAVFMELCV-ESPQWLFKRGRAAEAEA 251
Cdd:cd17367 135 RGFYSSFQYVTLIGGQLLALGVLLVLQHTLGedqmaaWgWRIPFLLGGV-LAVVVLWLRRGLeETESFEAIAESNEASAG 213
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 252 VFEKLL--------------GGS---YVKA-AMAELVKSDRGDDADSAKLSELLFGRSFR-GSTVAVVLMDKLGRKVLLI 312
Cdd:cd17367 214 TLRELRrhprelllvvgltaGGTlafYTWTtYLQKFLVNTAGFSKGDATWITTAALLVFMlLQPLGGRLSDRIGRRPLLL 293
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 79321503 313 GSF-AGMAVSLGLQAIAyTSLPSPFGTLFLSVGGmlLFVLSFATGAGPVpslLLSEICPGRLRATALAVCLAV 384
Cdd:cd17367 294 FFGiGGTLATVPLLSAL-DHTDSPYTAFALVLVG--LVFLSGYTSINAV---VKAELFPTHVRALGVGLPYAL 360
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
63-230 1.03e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 53.75  E-value: 1.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  63 LTSLLFGYHLGVVNETLESISIDLGFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSAS 142
Cdd:cd17489   3 LANFFFFLSFYLLLPVLPLYAHDLGGSEAVA--GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 143 TESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGT----YGSSTQIATCIG-LLGSLFAgipakDNLGWWRIcFW 217
Cdd:cd17489  81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEgigyYGLATTLAMALGpALGLFLY-----QHLGFAVL-FI 154
                       170
                ....*....|...
gi 79321503 218 ISTVPAAMLAVFM 230
Cdd:cd17489 155 VAAVLALLALLLV 167
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
96-384 2.44e-07

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 52.66  E-value: 2.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   96 GLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIG-PSVTALYVTEV 174
Cdd:PRK11551  53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGAlPNLIALTSEAV 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  175 SPAYvRGTYGSSTQIAT-CIGLLGSLFAGIPAKDnlGWWRICFWISTV-PAAMLAVFMELCVESPQWLFKRGRAAEAEAV 252
Cdd:PRK11551 133 GPRL-RGTAVSLMYCGVpFGGALASVIGVLAAGD--AAWRHIFYVGGVgPLLLVPLLMRWLPESRAFAQAAGAGKQRAPV 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  253 FEKLLGGSYVKAAMA-------------------ELVKSDRGDDADSAKLSELLFG-RSFRGSTVAVVLMDKLGRKVLLI 312
Cdd:PRK11551 210 LRALFGEGRATATLLlwisyfftlivlyfllnwlPSLLVGQGLSRSQAGLVQIAFNiGGALGSLLIGALMDRLRPRRVVL 289
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 79321503  313 GSFAGMAVSLGLQAIAYTSLPSPFGTLFLsvgGMllfvlsFATGAGPVPSLLLSEICPGRLRATALAVCLAV 384
Cdd:PRK11551 290 LIYAGILASLAALAAAPSFAGMLLAGFAA---GL------FVVGGQSVLYALAPLFYPTQVRGTGVGAAVAV 352
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
95-421 3.93e-07

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 51.77  E-value: 3.93e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  95 EGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYvTEV 174
Cdd:cd17372  36 VALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQLASWY-LEF 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 175 SPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNLGW-WRICFwiSTVPAAMLAVFMELCVESPQ--WLFKRGRA----- 246
Cdd:cd17372 115 LPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWrWLLAF--SSVPSSLLLVFYRWTPKTTLllWVIWFGNAfayyg 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 247 ---AEAEAVFEKLLGGSYVKAAMAELVKSDRGDDADSAKLSELLFGR--SFRGSTVAVVLMDKLGRKvlligsfAGMAVS 321
Cdd:cd17372 193 vvlLTTELNNSHNVCGSKSDSDSGESPTEKQCRNSNDVDYRDVFIATfaEFPGLLISAAMIDRLGRK-------ASMASM 265
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 322 LGLQAIAYTSLPSPFGTLFLSVggmLLFVL-SFATGAGPVPSLLLSEICPGRLRATALAVCLAVHWVINFFVGLLFLRML 400
Cdd:cd17372 266 LFTCCIFLLLLLICQSPFILTV---LLFGGrACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLV 342
                       330       340
                ....*....|....*....|..
gi 79321503 401 EqlGSVLLN-AIFGFFCVVAVI 421
Cdd:cd17372 343 H--GSQTIAlLLFSVVCLVSAI 362
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
90-218 3.99e-07

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 52.24  E-value: 3.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  90 GNTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTAL 169
Cdd:cd06179  29 GPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAV 108
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 79321503 170 YVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNLGWWRICFWI 218
Cdd:cd06179 109 ASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAGWRWIFYI 157
2A0112 TIGR00891
putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic ...
108-265 5.78e-07

putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273324 [Multi-domain]  Cd Length: 405  Bit Score: 51.42  E-value: 5.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   108 IGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSST 187
Cdd:TIGR00891  62 FGALMFGLWGDRYGRRLPMVTSIVLFSAGTLACGFAPGYITMFIARLVIGIGMGGEYGSSAAYVIESWPKHLRNKASGLL 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   188 QIATCIGllgSLFAGIPAKDNLGW----WRICFWISTVPAAMLAVFMELCVESPQWLFKRGRAAEAEAVFEKLLGGSYVK 263
Cdd:TIGR00891 142 ISGYAVG---AVVAAQVYSLVVPVwgdgWRALFFISILPIIFALWLRKNIPEAEDWKEKHAGKALVRTMVDILYGGEHRI 218

                  ..
gi 79321503   264 AA 265
Cdd:TIGR00891 219 AN 220
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
62-228 1.12e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 50.27  E-value: 1.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  62 SLTSLLFGYHLGVVNETLESISIDLGFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSA 141
Cdd:cd17504   2 ALAALAVMLVETMLSPALPTIQREFGTSAAAV--SWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 142 STESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAkDNLGwWRICFWISTV 221
Cdd:cd17504  80 FAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIV-QHLG-WRWIFWTAAP 157

                ....*..
gi 79321503 222 PAAMLAV 228
Cdd:cd17504 158 VAVLLAA 164
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
82-423 2.20e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 49.49  E-value: 2.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  82 ISIDLGFSgnTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMG 161
Cdd:cd17319  29 IMKDLGLS--PTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 162 IGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGL-LGSLFAGIPAkdNLGWWRICFWISTVPAAMLAVFMelcvespqWL 240
Cdd:cd17319 107 GFFPGAIKALAEWFPARERGRATGLFNSGAPLGAaIGPPLSGWLL--LLFGWRWAFIIEGLLGLLLAVLW--------WF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 241 FKRGRAAEAEAVFEKLLGGSYVKAAMAELVKSDRG-DDADSAKLSELLFGRSFRGSTVAVVLMDKL---GRKVLLIGSFA 316
Cdd:cd17319 177 YLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGfSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLL 256
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 317 GMAVSLGLQAIaytslpspFGTLFLSVGGMLLFVLSFATGAGPVPSlLLSEICPGRLRATALAVCLAVHWVINFFVGLLF 396
Cdd:cd17319 257 LAAVGLLLAYL--------TTSPVVAVILLSLAGFGIGAASPVFWS-LPADLLPGEAAATAGGLINSGGNLGGFVAPLLI 327
                       330       340
                ....*....|....*....|....*..
gi 79321503 397 LRMLEQLGSvlLNAIFGFFCVVAVIFV 423
Cdd:cd17319 328 GYLVDATGS--YTAAFLFLAAVALLAA 352
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
108-380 2.75e-06

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 49.45  E-value: 2.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 108 IGSLFSGLVADGVGRRRAFQLSALPMivGASVSastesLMGML---------------LGRFLVGIGMGIGPSVTALYVT 172
Cdd:cd17369  59 LGGVVFGHFGDRIGRKKTLVLTLLLM--GIATF-----LIGLLptyaqigilapillvLLRLLQGLALGGEWGGAVLMAV 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 173 EVSPAYVRGTYGSSTQIATCIGLLGS-----LFAGIPAKDN-LGW-WRICFWIStvpAAMLAV--FMELCV-ESPqwLFK 242
Cdd:cd17369 132 EHAPPKRRGFYGSFPQLGAPVGLLLAtgvflLLSALLSDEAfLSWgWRIPFLLS---AVLVAVglYIRLRLeETP--VFR 206
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 243 RGRAAEAEAVFEK----------LLGGSYVKAAMAEL-----------VKSDRGDDADSAKLSELLfgrsfrGSTVAVV- 300
Cdd:cd17369 207 RAKEAGQVVRAPLvevlrrhwraLLLAIGLRLAENVLfylfttfalsyATQTLGVDRSTVLLAVLI------ASVVAAIt 280
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 301 ------LMDKLGRKVLLIGSFAGMAVSlglqAIAYTSLPSPFGTLFLSVGGMLLFVLSFATGAGPVPSlLLSEICPGRLR 374
Cdd:cd17369 281 iplfgwLSDRVGRRPVYLAGALLAALF----AFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAA-FLAELFPTRVR 355

                ....*.
gi 79321503 375 ATALAV 380
Cdd:cd17369 356 YTGASL 361
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
56-194 3.20e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 48.82  E-value: 3.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  56 PHVLVASLTSLLFGYHLGVVNETLESISID-LGFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMI 134
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAA--GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 135 VGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIG 194
Cdd:COG2814 285 LGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
11-256 8.73e-06

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 48.05  E-value: 8.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503    11 MRGRHIDKRVPSKEFLSA---LDKAETAVRLPTgTGKDCGNPSWKRSLPHVLVASLtsLLFGYHLGVVNETLESISIDLG 87
Cdd:TIGR01299 122 VRDELKDGEGPPGGEGEAerrADEEELAQQYEL-IIQECGHGRFQWALFFVLGLAL--MADGVEVFVVGFVLPSAEKDLC 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503    88 FSGNtiAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVT 167
Cdd:TIGR01299 199 IPDS--GKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIV 276
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   168 ALYVTEVSPAYVRGTYGSSTQIATCIGLL---GSLFAGIPakdNLGW------------WRICFWISTVPAAMLAVFMEL 232
Cdd:TIGR01299 277 FSYFAEFLAQEKRGEHLSWLCMFWMIGGIyaaAMAWAIIP---HYGWsfqmgsayqfhsWRVFVIVCAFPCVFAIGALTF 353
                         250       260
                  ....*....|....*....|....
gi 79321503   233 CVESPQWLFKRGRAAEAEAVFEKL 256
Cdd:TIGR01299 354 MPESPRFFLENGKHDEAWMILKLI 377
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
85-380 1.14e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.19  E-value: 1.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  85 DLGFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGP 164
Cdd:cd17325  25 SLGASVAQI--GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVW 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 165 SVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNLGwWRICFWISTVPAAMLAVFMELCVE---SPQWLF 241
Cdd:cd17325 103 PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALALLALVLALLLLPeprPPPNKR 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 242 KRGRAAEAEAVFEKLLGGSYVKAAMAELVKS---------------DRGDdaDSAKLSELLFGRSFRGSTVAVVLM---- 302
Cdd:cd17325 182 AVSAARLRSGLRLLLRDRRLLALFLAIFVLAfafgalepflplyaaELGG--LSPAQIGLLFGAQGLASALSQPPAgkls 259
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 79321503 303 DKLGRKVLLIGSFAGMAVSLGLqaiayTSLPSPFGTLFLsvggmLLFVLSFATG-AGPVPSLLLSEICPGRLRATALAV 380
Cdd:cd17325 260 DRIGRKPLILIGLLLSAVALLL-----LPLATSFWLLLL-----LLALLGLGLGlVFPATLALLADIVPPEGRGTAMGL 328
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
96-380 1.61e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 46.79  E-value: 1.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  96 GLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVS 175
Cdd:cd17474  37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLF 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 176 PAYVR----GTYGSSTQIATCIG-LLGSLFAGIpakdnlgWWRICFWISTVPAAMLAVFMELCVESP----QWLFKRGRA 246
Cdd:cd17474 117 EGGERakamGLYEAALGLGIAVGpLLGGLLAAI-------SWRYPFFLLAALIPVAFLAILFLLPEPkekaKSSSATKLR 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 247 AEAEAVFEKLLGGSYVKAAM------AELVKS----DRGDDADSAKLSELLFGRSFRGSTVAVV----LMDKLGRKVLLI 312
Cdd:cd17474 190 DLKKALRGRGLLTFLVSAFLyfflyfAFLTYLpfllELLYGISPIIIGLLFAGWSVLLALGSLFvgrlLKKRFGARRILV 269
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 79321503 313 GSFAGMAVSLGLQAIAYtslpspfgtlflSVGGMLLFVLSFATGAGPVPSL---LLSEICPGRLRATALAV 380
Cdd:cd17474 270 IGLLLYALSLLLLGFVP------------SLALLLIAIVLFGLGLGLNLPLlttLVTELAPEEERGTASSL 328
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
79-261 1.78e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 46.80  E-value: 1.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  79 LESISIDLGFSGNTIAegLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGI 158
Cdd:cd17320  22 LPAIARDLGASASAVQ--LTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGL 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 159 GMGiGPSVtalyvteVSPAYVRGTYgSSTQIATCIGLLGSLFAGIPA--------KDNLGWWRICFWISTVPAAMLAVFM 230
Cdd:cd17320 100 GAA-AGSV-------VARAIVRDLY-SGAELAKIFSLLMMILAIAPAlapllgglLLLFFGWRAIFVFLALLGLLLLLLV 170
                       170       180       190
                ....*....|....*....|....*....|.
gi 79321503 231 elcvespQWLFKRGRAAEAEAVFEKLLGGSY 261
Cdd:cd17320 171 -------LLFLPETLPEEKRKPLLSSLLRAY 194
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
96-230 3.77e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.64  E-value: 3.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  96 GLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVS 175
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 79321503 176 PAYVRGTYGSSTQIATCIGL-LGSLFAGIpAKDNLGwWRICFWISTVPAAMLAVFM 230
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMvLGPLLGGF-LYDAFG-FATPFLAAAALLLLAAVLF 371
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
58-230 4.92e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 45.24  E-value: 4.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  58 VLVASLTSLLFGyhlGVVNETLESISIDLGFSGNTIAEGLVVSTCLGGAFIgsLFSGLVADGVGRRRAFQLSALPMIVGA 137
Cdd:cd17321   1 LLLAVFLAALDV---TIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALL--LLAGRLGDRFGRKRVFLIGLALFGLAS 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 138 SVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVR----GTYGSSTQIATCIG-LLGSLFAgipakdNLGWW 212
Cdd:cd17321  76 LLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRgralGLWGAVVGIGAALGpLLGGLLL------ELFGW 149
                       170
                ....*....|....*...
gi 79321503 213 RICFWIStVPAAMLAVFM 230
Cdd:cd17321 150 RWIFLIN-VPIGLVALLL 166
2_A_01_02 TIGR00880
Multidrug resistance protein;
105-231 5.44e-05

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 43.02  E-value: 5.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   105 GAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYG 184
Cdd:TIGR00880  10 GQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVAL 89
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 79321503   185 SSTQIATCIGLLGSLFAGIPAKDNLGwWRICFWI----STVPAAMLAVFME 231
Cdd:TIGR00880  90 GLMSAGIALGPLLGPPLGGVLAQFLG-WRAPFLFlailALAAFILLAFLLP 139
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
96-250 6.92e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.87  E-value: 6.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  96 GLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGAS-VSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEV 174
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLlLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDI 323
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 79321503 175 SPAYVRGT-YGSSTQIATCIGLLGSLFAGIpAKDNLGWWRICFWISTVPAAMLAVFMelcvespQWLFKRGRAAEAE 250
Cdd:COG2223 324 FPTKNAGAvYGLVGAAGGLGGFLGPLLFGA-LLDATGSYTAAFLVFAVLALVALVLT-------LLLYRRPRRAAAA 392
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
105-230 9.92e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 44.11  E-value: 9.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 105 GAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYG 184
Cdd:cd17317  37 GVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVG 116
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 79321503 185 SSTQIATCIGLLGSLFAGIPAKDnlgwWRICFWISTVPAAMLAVFM 230
Cdd:cd17317 117 ILFGLFWALGYMLLALLAYLIRD----WRWLQLAISLPGLLFLLLL 158
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
79-229 1.38e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 44.09  E-value: 1.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  79 LESISIDLGFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGI 158
Cdd:COG2807  41 LPEIRADLGLSATQA--GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA 118
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 79321503 159 GMGIGPSVTALYVTEVSPAYVR---GTYGSSTQIATCIGLLGSlfagIPAKDNLGwWRICFWISTVPAAMLAVF 229
Cdd:COG2807 119 GIAVGNVLLPGLIKRWFPDRVGlmtGLYTAAMGLGAALAAGLT----VPLAAALG-WRGALAVWALLALLALLL 187
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
59-256 1.90e-04

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 43.76  E-value: 1.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  59 LVASLTSLLFGYHLGVVNETLESISIDLGFS-GNTIAEGLVVSTclgGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGA 137
Cdd:cd17438   2 FVLGLALMADGVEVFVVGFVLPSAEKDMCLSsSNKGMLGLIVYL---GMMAGAFIWGGLADKLGRKRCLIISLAINASFA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 138 SVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIatcIGLLGSLFAGIPAKD---NLGW--- 211
Cdd:cd17438  79 FLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCM---FWMIGGLYASAMAWSiipHYGWgfs 155
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 79321503 212 ---------WRICFWISTVPAAMLAVFMELCVESPQWLFKRGRAAEAEAVFEKL 256
Cdd:cd17438 156 mgtnyhfhsWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNI 209
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
86-228 2.05e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 43.28  E-value: 2.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  86 LGFSGNTIAEGLVVSTCLGGAFIgsLFSGLVADGVGRRRAFQLSALPMIVGA----SVSASTESLMGMLLGRFLVGIGMG 161
Cdd:cd17369 259 LGVDRSTVLLAVLIASVVAAITI--PLFGWLSDRVGRRPVYLAGALLAALFAfpffWLLDTGSTWLIVLAAVVVLGVLHG 336
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 79321503 162 IGPSVTALYVTEVSPAYVRGTYGS-STQIATCI-GLLGSLFAGIPAKDNLGWWricfWISTVPAAMLAV 228
Cdd:cd17369 337 MMYGPQAAFLAELFPTRVRYTGASlGYQLGAILgGGFAPLIATALVAATGSWW----PVALYLAALAVI 401
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
88-176 4.63e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 42.31  E-value: 4.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  88 FSGNTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVT 167
Cdd:cd17333  26 FNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGA 105

                ....*....
gi 79321503 168 ALYVTEVSP 176
Cdd:cd17333 106 NTFVGALFE 114
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
56-229 6.64e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.77  E-value: 6.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  56 PHVLVASL-TSLLFGYHLGVVNeTLESISIDL-GFSGNTIaeGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPM 133
Cdd:cd17324 198 PRLRLAYLiTFLLFGGFFALYT-YLAPFLTDVpGFSSSAI--IGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLA 274
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 134 IVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAyVRGTYGSSTQIATCIGL-LGSLFAGIpAKDNLGWW 212
Cdd:cd17324 275 AALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE-ARGLASSLYLAAYNLGGaLGAALGGL-VLDHGGWA 352
                       170
                ....*....|....*..
gi 79321503 213 RICFWISTVPAAMLAVF 229
Cdd:cd17324 353 GVGWVGAALLLLALLLA 369
PRK12307 PRK12307
MFS transporter;
69-239 7.88e-04

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 41.45  E-value: 7.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   69 GYHLGVVNETLESISIDLGFSgnTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMG 148
Cdd:PRK12307  31 GFDFMLIFYIMYLIKADLGLT--DMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIM 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  149 MLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTygSSTQIATCIGlLGSLFAG--IPAKDNLGWWRICFWISTVPAAML 226
Cdd:PRK12307 109 LTLSRFIVGMGMAGEYACASTYAVESWPKHLKSK--ASAFLVSGFG-IGNIIAAyfMPSFAEAYGWRAAFFVGLLPVLLV 185
                        170
                 ....*....|...
gi 79321503  227 AVFMELCVESPQW 239
Cdd:PRK12307 186 IYIRARAPESKEW 198
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
74-346 2.54e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 39.87  E-value: 2.54e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  74 VVNETLESISIDLGFSGNTIAegLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGR 153
Cdd:cd17503  14 IVNVALPTIMGDLGASLDTVQ--WVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFR 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 154 FLVGIGMGIGPSVTALYVTEVSPAYVRGT----YGSSTQIATCIG-LLGSLFAgipakDNLGwWRICFWISTVPAAMLAV 228
Cdd:cd17503  92 ILQGFGGGVLIPLAQTILLRIYPPEKRGAamglVGLVILLAPAIGpTLGGWLT-----DNLS-WRWIFYINLPIGILALL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 229 FMELCvesPQWLFKRgRAAEAEAVFEKLLGGSYVKAAM--AELVKSDRGDDADSAKLSELLFG-RSFRGSTVAVVLMDKL 305
Cdd:cd17503 166 LAPLL---DLRLFKD-RNFTLGLLLSFLLGLGLFGAMFllPLYLQNVLGYSAFESGLVLAPGGlASAILSPLVGRLLDKF 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 79321503 306 GRKVLLIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLSVGGM 346
Cdd:cd17503 242 GPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGL 282
MFS_1 pfam07690
Major Facilitator Superfamily;
56-194 2.84e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503    56 PHVLVASLTSLLFGYHLGVVNETLESISIDLGFSgnTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIV 135
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS--ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 79321503   136 GA---SVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIG 194
Cdd:pfam07690 278 AAlglLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
58-203 3.24e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 39.65  E-value: 3.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503    58 VLVASLTSLLFGYHLgvVNETLESISIDLGFSGNTIAEGLVVSTClgGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGA 137
Cdd:TIGR00895 254 LLWLLYFMLLVGVYF--LTNWLPKLMVELGFSLSLAATGGALFNF--GGVIGSIIFGWLADRLGPRVTALLLLLGAVFAV 329
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 79321503   138 SVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTyGSSTQIAtcIGLLGSLFAGI 203
Cdd:TIGR00895 330 LVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRAT-GVGWAIG--IGRLGAIIGPI 392
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
108-169 3.25e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 39.48  E-value: 3.25e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 79321503 108 IGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMG-IGPSVTAL 169
Cdd:cd17473  50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAgIMTLATAL 112
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
68-234 3.66e-03

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 39.53  E-value: 3.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  68 FGYHLGVVNETLES--ISIDLGFSGNTIAeglVVSTCLGGAF-IGSLFSGLVADGVGRRRAFQ----LSALPMIVGASVS 140
Cdd:cd17345  13 AGYYLVRNNFSLAQpyLIEQYGLSKTEIG---LIGSALSIAYgLSKFVMGNLSDRSNPKRFLAigliLSAIINILIGFVP 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 141 ASTESLMGMLLGRFLVGI--GMGIGPSvtALYVTEVSPAYVRGTYGSSTQIATCIG--LLGSLFAGIPAKDNLGWWRICF 216
Cdd:cd17345  90 SATSSVGLMFILLFLNGWfqGMGWPPS--GRTMVHWFSKKERGTWTSIWNISHNVGggLVGPLAGLGLAIFGDGWWRGAF 167
                       170
                ....*....|....*...
gi 79321503 217 WIstvpAAMLAVFMELCV 234
Cdd:cd17345 168 IF----PAIIAIIVAVIV 181
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
59-228 3.80e-03

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 39.17  E-value: 3.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  59 LVASLTSLLFGYHLGVVNETLESISIDLGFSGNTIAEGLVVSTCLGGAFIgsLFSGLVADGVGRRRAFQLSALPMIVGAS 138
Cdd:cd17476   1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFI--LIFGRLGDIYGHKKMFVIGSFWFAIWSL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 139 VSASTESLMGMLLGRFLVGIGMG-IGPSVTALyVTEVSPAYVRGTYGSSTQIAT-CIG-LLGSLFAGIPAKdnLGWWRIC 215
Cdd:cd17476  79 IAGFSPNFIFFIICRALQGLGPAfLLPNAMAL-LGRTYPPGPRKNIVFSLFGATaPLGfALGGVFGGLFAQ--LAWWPWI 155
                       170
                ....*....|...
gi 79321503 216 FWISTVPAAMLAV 228
Cdd:cd17476 156 FWFLAILAAIVAV 168
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
96-229 4.08e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.45  E-value: 4.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  96 GLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVS 175
Cdd:COG0738 249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGL 328
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 79321503 176 PAYVRGTYGSSTQIATCIGLLGSLFAGIPAkDNLGwWRICFWISTVPAAMLAVF 229
Cdd:COG0738 329 GKRTAAAVSAVLIMGIVGGAIGPPLIGFLA-DAFG-LRAAFLVPLVCYLLILLL 380
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
56-229 5.16e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.95  E-value: 5.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  56 PHVLVASLTSLLFGYHLGVVNETLESISIDLGFSGNTIAeGLVVSTCLGGAFIGSLFSGLVAD-GVGRRRAFQLSALPMI 134
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA-GLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMA 281
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 135 VGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTY-GSSTQIATCIGLLGSLFAGIPAKDNLGWwR 213
Cdd:cd06174 282 LGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAfGLLNTFGFLGGAIGPLLAGFLLAATFGL-T 360
                       170
                ....*....|....*.
gi 79321503 214 ICFWISTVPAAMLAVF 229
Cdd:cd06174 361 GAFLVLAVLLLLAAIL 376
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
50-221 6.36e-03

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 38.75  E-value: 6.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   50 SWKRSLphvLVASLTSLLFGYHLGVVNETLESISIDLGFSGNT---IAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAF 126
Cdd:PRK09874  11 NWKRNL---TVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSalnMWSGLVFSITFLFSAIASPFWGGLADRKGRKIML 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503  127 QLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAk 206
Cdd:PRK09874  88 LRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLA- 166
                        170
                 ....*....|....*
gi 79321503  207 DNLGWWRICFWISTV 221
Cdd:PRK09874 167 DSYGLRPVFFITASV 181
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
89-251 8.36e-03

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 38.56  E-value: 8.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503    89 SGNTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIV-----GASVSASTESLMGMLL-GRFLVGIGMGI 162
Cdd:TIGR00887  52 PLPSSVSAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIatvasGLSPGSSPKSVMATLCfWRFWLGVGIGG 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503   163 GPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGI------------------------PAKDNLgwWRICFWI 218
Cdd:TIGR00887 132 DYPLSAIITSEFATKKWRGAMMAAVFAMQGFGILAGAIVALivlagfkhsleaaadeasctgscvPAVDYM--WRILIGF 209
                         170       180       190
                  ....*....|....*....|....*....|...
gi 79321503   219 STVPAAMLAVFMELCVESPQWLFKRGRAAEAEA 251
Cdd:TIGR00887 210 GAVPALLALYFRLTIPETPRYTADVAKDVEQAA 242
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
105-249 9.28e-03

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 38.24  E-value: 9.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79321503 105 GAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYG 184
Cdd:cd17363  46 GMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHL 125
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 79321503 185 SSTQIATCIGLLGSLFAGIPAKDNLGW------------WRICFWISTVPAAMLAVFMELCVESPQWLFKRGRAAEA 249
Cdd:cd17363 126 SWLCMFWMIGGLYASAMAWAIIPHYGWgfsmgtayqfhsWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEA 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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