NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|79316065|ref|NP_001030914|]
View 

AUTOPHAGY 6 [Arabidopsis thaliana]

Protein Classification

beclin family protein( domain architecture ID 16048792)

beclin family protein plays an essential role in autophagy and other membrane-trafficking events, such as human beclin-2 that is involved in 2 distinct lysosomal degradation pathways: acting as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover

Gene Ontology:  GO:0006914|GO:0000045|GO:0045324
PubMed:  26071895|31776982
SCOP:  4004436

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
APG6 pfam04111
Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 236-295 1.53e-32

Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway. This entry is the Beta-Alpha repeated, autophagy-specific (BARA) domain.


:

Pssm-ID: 461178  Cd Length: 176  Bit Score: 118.80  E-value: 1.53e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 79316065   236 TNVLIDAFPIRNDGEFGTINNFRLGRLPAIKVEWDEINAAWGQACLLLHTMCNYFRPKFQ 295
Cdd:pfam04111   1 TNVYNDTFHISHDGPFGTINGLRLGRLPNVPVEWSEINAAWGQTALLLATLAKKLGLKFQ 60
APG6_N pfam17675
Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 102-230 3.53e-28

Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.


:

Pssm-ID: 465452 [Multi-domain]  Cd Length: 127  Bit Score: 105.76  E-value: 3.53e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79316065   102 PLCLECMRVLSDKLEKEVEDVTRDVEAYEACVQRLEgeTQDVLSEADFLKEKKKIEEEERKLVAAIEETEKQNAEVNHQL 181
Cdd:pfam17675   1 PLCEECTDLLLEELDKQLEDAEKERDAYISFLKKLE--KETPEELEELEKELEKLEKEEEELLQELEELEKEREELDAEL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 79316065   182 KELEFKGNRFNELEDRYWQEFNNFQFQLIAHQEERDAILAKIEVSQAHL 230
Cdd:pfam17675  79 EALEEELEALDEEEEEFWREYNALQLQLLEFQDERDSLEAQYEHALNQL 127
 
Name Accession Description Interval E-value
APG6 pfam04111
Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 236-295 1.53e-32

Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway. This entry is the Beta-Alpha repeated, autophagy-specific (BARA) domain.


Pssm-ID: 461178  Cd Length: 176  Bit Score: 118.80  E-value: 1.53e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 79316065   236 TNVLIDAFPIRNDGEFGTINNFRLGRLPAIKVEWDEINAAWGQACLLLHTMCNYFRPKFQ 295
Cdd:pfam04111   1 TNVYNDTFHISHDGPFGTINGLRLGRLPNVPVEWSEINAAWGQTALLLATLAKKLGLKFQ 60
APG6_N pfam17675
Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 102-230 3.53e-28

Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.


Pssm-ID: 465452 [Multi-domain]  Cd Length: 127  Bit Score: 105.76  E-value: 3.53e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79316065   102 PLCLECMRVLSDKLEKEVEDVTRDVEAYEACVQRLEgeTQDVLSEADFLKEKKKIEEEERKLVAAIEETEKQNAEVNHQL 181
Cdd:pfam17675   1 PLCEECTDLLLEELDKQLEDAEKERDAYISFLKKLE--KETPEELEELEKELEKLEKEEEELLQELEELEKEREELDAEL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 79316065   182 KELEFKGNRFNELEDRYWQEFNNFQFQLIAHQEERDAILAKIEVSQAHL 230
Cdd:pfam17675  79 EALEEELEALDEEEEEFWREYNALQLQLLEFQDERDSLEAQYEHALNQL 127
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
105-235 6.22e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 38.12  E-value: 6.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79316065  105 LECMRVLSDKLEK-EVEDVTRDVEAYEACVQRLEGETQDVLSEADFLKEKKKIEEEERKLVAAIEETEKQNAEVNHQLKE 183
Cdd:PRK03918 502 AEQLKELEEKLKKyNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEE 581

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 79316065  184 LEFKG-----NRFNELEDRY--WQEFNNFQFQLIAHQEERDAILAKIEVSQAHLELLNK 235
Cdd:PRK03918 582 LGFESveeleERLKELEPFYneYLELKDAEKELEREEKELKKLEEELDKAFEELAETEK 640
 
Name Accession Description Interval E-value
APG6 pfam04111
Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 236-295 1.53e-32

Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway. This entry is the Beta-Alpha repeated, autophagy-specific (BARA) domain.


Pssm-ID: 461178  Cd Length: 176  Bit Score: 118.80  E-value: 1.53e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 79316065   236 TNVLIDAFPIRNDGEFGTINNFRLGRLPAIKVEWDEINAAWGQACLLLHTMCNYFRPKFQ 295
Cdd:pfam04111   1 TNVYNDTFHISHDGPFGTINGLRLGRLPNVPVEWSEINAAWGQTALLLATLAKKLGLKFQ 60
APG6_N pfam17675
Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 102-230 3.53e-28

Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.


Pssm-ID: 465452 [Multi-domain]  Cd Length: 127  Bit Score: 105.76  E-value: 3.53e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79316065   102 PLCLECMRVLSDKLEKEVEDVTRDVEAYEACVQRLEgeTQDVLSEADFLKEKKKIEEEERKLVAAIEETEKQNAEVNHQL 181
Cdd:pfam17675   1 PLCEECTDLLLEELDKQLEDAEKERDAYISFLKKLE--KETPEELEELEKELEKLEKEEEELLQELEELEKEREELDAEL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 79316065   182 KELEFKGNRFNELEDRYWQEFNNFQFQLIAHQEERDAILAKIEVSQAHL 230
Cdd:pfam17675  79 EALEEELEALDEEEEEFWREYNALQLQLLEFQDERDSLEAQYEHALNQL 127
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
105-235 6.22e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 38.12  E-value: 6.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79316065  105 LECMRVLSDKLEK-EVEDVTRDVEAYEACVQRLEGETQDVLSEADFLKEKKKIEEEERKLVAAIEETEKQNAEVNHQLKE 183
Cdd:PRK03918 502 AEQLKELEEKLKKyNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEE 581

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 79316065  184 LEFKG-----NRFNELEDRY--WQEFNNFQFQLIAHQEERDAILAKIEVSQAHLELLNK 235
Cdd:PRK03918 582 LGFESveeleERLKELEPFYneYLELKDAEKELEREEKELKKLEEELDKAFEELAETEK 640
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH