NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|77683225|ref|NP_001029329|]
View 

G patch domain and ankyrin repeat-containing protein 1 [Rattus norvegicus]

Protein Classification

ankyrin repeat domain-containing protein; ankyrin repeat and MYND domain-containing protein( domain architecture ID 12122224)

ankyrin repeat (ANK) domain-containing protein mediates specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions| ankyrin repeat and MYND domain-containing protein similar to ANKMY2 that may be involved in the trafficking of signaling proteins to the cilia

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 249-293 2.43e-13

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


:

Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 63.68  E-value: 2.43e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 77683225   249 TSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYR 293
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
100-190 9.07e-12

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.98  E-value: 9.07e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77683225 100 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEA 179
Cdd:COG0666 157 LHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAEN 229

                        90
                ....*....|.
gi 77683225 180 GFPEVARMVRE 190
Cdd:COG0666 230 GNLEIVKLLLE 240
 
Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 249-293 2.43e-13

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 63.68  E-value: 2.43e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 77683225   249 TSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYR 293
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 247-292 3.16e-12

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 60.64  E-value: 3.16e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 77683225    247 VPTSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGY 292
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGA 46
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
100-190 9.07e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.98  E-value: 9.07e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77683225 100 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEA 179
Cdd:COG0666 157 LHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAEN 229

                        90
                ....*....|.
gi 77683225 180 GFPEVARMVRE 190
Cdd:COG0666 230 GNLEIVKLLLE 240
Ank_2 pfam12796
Ankyrin repeats (3 copies);
100-187 2.30e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 2.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77683225   100 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWvgvCELGGRDAAQLAEEA 179
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE------NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARS 71


                  ....*...
gi 77683225   180 GFPEVARM 187
Cdd:pfam12796  72 GHLEIVKL 79
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 104-240 2.40e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.88  E-value: 2.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77683225  104 AQNGDLTELRRLLEpqeaGGAggNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEAGFPE 183
Cdd:PTZ00322  90 AASGDAVGARILLT----GGA--DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGAD-PTLLDKDGKTPLELAEENGFRE 162

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 77683225  184 VARMVreSRGETRSPENQNRSPPSSSQFCEdcgAYFEDSnhrTSTAHLLSLSRRPQP 240
Cdd:PTZ00322 163 VVQLL--SRHSQCHFELGANAKPDSFTGKP---PSLEDS---PISSHHPDFSAVPQP 211
 
Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 249-293 2.43e-13

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 63.68  E-value: 2.43e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 77683225   249 TSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYR 293
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 247-292 3.16e-12

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 60.64  E-value: 3.16e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 77683225    247 VPTSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGY 292
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGA 46
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
100-190 9.07e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.98  E-value: 9.07e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77683225 100 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEA 179
Cdd:COG0666 157 LHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAEN 229

                        90
                ....*....|.
gi 77683225 180 GFPEVARMVRE 190
Cdd:COG0666 230 GNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
100-187 4.89e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.66  E-value: 4.89e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77683225 100 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEA 179
Cdd:COG0666  91 LHAAARNGDLEIVKLLLE------AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAD-VNAQDNDGNTPLHLAAAN 163


                ....*...
gi 77683225 180 GFPEVARM 187
Cdd:COG0666 164 GNLEIVKL 171
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
100-187 1.28e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.51  E-value: 1.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77683225 100 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEA 179
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLE------AGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD-VNARDNDGETPLHLAAEN 196


                ....*...
gi 77683225 180 GFPEVARM 187
Cdd:COG0666 197 GHLEIVKL 204
Ank_2 pfam12796
Ankyrin repeats (3 copies);
100-187 2.30e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 2.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77683225   100 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWvgvCELGGRDAAQLAEEA 179
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE------NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARS 71


                  ....*...
gi 77683225   180 GFPEVARM 187
Cdd:pfam12796  72 GHLEIVKL 79
Ank_4 pfam13637
Ankyrin repeats (many copies);
100-155 2.75e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.88  E-value: 2.75e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 77683225   100 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLL 155
Cdd:pfam13637   5 LHAAAASGHLELLRLLLE------KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
102-187 2.26e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 48.41  E-value: 2.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77683225 102 MAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWVGVCELGGRDAAQLAEEAGF 181
Cdd:COG0666 192 LAAENGHLEIVKLLLE------AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAA 265


                ....*.
gi 77683225 182 PEVARM 187
Cdd:COG0666 266 LIVKLL 271
Ank_2 pfam12796
Ankyrin repeats (3 copies);
100-159 1.10e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.57  E-value: 1.10e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 77683225   100 ILM-AAQNGDLTELRRLLEpqeaggaGGNINARDAFWwTPLMCAARAGQGAAVRYLLGRGA 159
Cdd:pfam12796  33 ALHlAAKNGHLEIVKLLLE-------HADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGA 85
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
101-187 6.98e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.17  E-value: 6.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77683225 101 LMAAQNGDLTELRRLLEpqeagGAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEAG 180
Cdd:COG0666  58 LLAAALAGDLLVALLLL-----AAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD-VNARDKDGETPLHLAAYNG 131


                ....*..
gi 77683225 181 FPEVARM 187
Cdd:COG0666 132 NLEIVKL 138
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 104-240 2.40e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.88  E-value: 2.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77683225  104 AQNGDLTELRRLLEpqeaGGAggNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEAGFPE 183
Cdd:PTZ00322  90 AASGDAVGARILLT----GGA--DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGAD-PTLLDKDGKTPLELAEENGFRE 162

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 77683225  184 VARMVreSRGETRSPENQNRSPPSSSQFCEdcgAYFEDSnhrTSTAHLLSLSRRPQP 240
Cdd:PTZ00322 163 VVQLL--SRHSQCHFELGANAKPDSFTGKP---PSLEDS---PISSHHPDFSAVPQP 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH