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Conserved domains on  [gi|77628045|ref|NP_001029317|]
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elongator complex protein 2 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234975)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-415 1.22e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 136.70  E-value: 1.22e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045  54 LNGHTARVNCLHWirtedgSPSTE-LVSGASDNRVIHWELENNQVLKsvRLQGHEGPVYAVHGIyqsgpSDGEQhalIAS 132
Cdd:cd00200   5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLR--TLKGHTGPVRDVAAS-----ADGTY---LAS 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 133 AASDSTVRLWSKKGSEvkCLQILKFGDGFVLTVCLSTlpdtDAPVLACGDDGGRIHLFvqqdDW--FQKMLSLCGHEDWI 210
Cdd:cd00200  69 GSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAFSP----DGRILSSSSRDKTIKVW----DVetGKCLTTLRGHTDWV 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 211 RGVEWATFGRdlFLASCSQDCLIRIWRLymkptsletedGSIRLKentftikdggvsttvavileTVLAGHENWVNAIHW 290
Cdd:cd00200 139 NSVAFSPDGT--FVASSSQDGTIKLWDL-----------RTGKCV--------------------ATLTGHTGEVNSVAF 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 291 QPsfykDGVlhqpvRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYGCQFGENGSMIIAHAFHGAMHLWKQS 370
Cdd:cd00200 186 SP----DGE-----KLLSSSSDGTIKLW--DLSTGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 77628045 371 TVNPRQwapeiVISGHFDGVQDLIWDPEGEFIITTSTDQTTRLFA 415
Cdd:cd00200 250 TGECVQ-----TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
274-694 3.72e-21

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.90  E-value: 3.72e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 274 LETVLAGHENWVNAIHWQPSfykdgvlhqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYGCQFGENGS 353
Cdd:COG2319  70 LLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRSVAFSPDGK 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 354 MIIAHAFHGAMHLWkqstvNPRQWAPEIVISGHFDGVQDLIWDPEGEFIITTSTDQTTRLfapWkkknqSQVTWHEIARP 433
Cdd:COG2319 134 TLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---W-----DLATGKLLRTL 200

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 434 QIHGYNLKCLAMI-DRFQFVSGADEKVLRVFsaprnfvenfsvisrqslshmlydednDLPEGAtvpalglsnkavfegd 512
Cdd:COG2319 201 TGHTGAVRSVAFSpDGKLLASGSADGTVRLW---------------------------DLATGK---------------- 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 513 mtyltseeeellspafgypqvifqpavlsepptedhllqntlwpEVQKLYGHGYEIFCVTCNNSKTLLASACkaaqkEHA 592
Cdd:COG2319 238 --------------------------------------------LLRTLTGHSGSVRSVAFSPDGRLLASGS-----ADG 268

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 593 AIILWSTTSWKQVQSLAYHTLTVTQMAFSPDDKFLLAVSRDRTWSLWkrqDVTSAEfdpffSLFAFTNkitsvHSRIIWS 672
Cdd:COG2319 269 TVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW---DLATGK-----LLRTLTG-----HTGAVRS 335

                       410       420
                ....*....|....*....|..
gi 77628045 673 CDWSPDSKYFFTGSRDKKVVVW 694
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLW 357
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 611-817 4.69e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 4.69e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 611 HTLTVTQMAFSPDDKFLLAVSRDRTWSLWkrqDVTSAEFDpffslfaFTNKitsVHSRIIWSCDWSPDSKYFFTGSRDKK 690
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELL-------RTLK---GHTGPVRDVAASADGTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 691 VVVW----GECNSSYNPMEHPINpcssildvgscvtavsvCPVLNPAQRYIVAvGLESGKICIYSWSKTNQET-----KD 761
Cdd:cd00200  75 IRLWdletGECVRTLTGHTSYVS-----------------SVAFSPDGRILSS-SSRDKTIKVWDVETGKCLTtlrghTD 136

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 77628045 762 WTSCVetTPSQSHTLGirrlcwkscsgsteqseegtewldfASCGEDHTVKIYRVN 817
Cdd:cd00200 137 WVNSV--AFSPDGTFV-------------------------ASSSQDGTIKLWDLR 165
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-415 1.22e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.70  E-value: 1.22e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045  54 LNGHTARVNCLHWirtedgSPSTE-LVSGASDNRVIHWELENNQVLKsvRLQGHEGPVYAVHGIyqsgpSDGEQhalIAS 132
Cdd:cd00200   5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLR--TLKGHTGPVRDVAAS-----ADGTY---LAS 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 133 AASDSTVRLWSKKGSEvkCLQILKFGDGFVLTVCLSTlpdtDAPVLACGDDGGRIHLFvqqdDW--FQKMLSLCGHEDWI 210
Cdd:cd00200  69 GSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAFSP----DGRILSSSSRDKTIKVW----DVetGKCLTTLRGHTDWV 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 211 RGVEWATFGRdlFLASCSQDCLIRIWRLymkptsletedGSIRLKentftikdggvsttvavileTVLAGHENWVNAIHW 290
Cdd:cd00200 139 NSVAFSPDGT--FVASSSQDGTIKLWDL-----------RTGKCV--------------------ATLTGHTGEVNSVAF 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 291 QPsfykDGVlhqpvRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYGCQFGENGSMIIAHAFHGAMHLWKQS 370
Cdd:cd00200 186 SP----DGE-----KLLSSSSDGTIKLW--DLSTGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 77628045 371 TVNPRQwapeiVISGHFDGVQDLIWDPEGEFIITTSTDQTTRLFA 415
Cdd:cd00200 250 TGECVQ-----TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
21-413 9.54e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 9.54e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045  21 ALSWNSGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLHWirTEDGspsTELVSGASDNRVIHWELENNQVLKS 100
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF--SPDG---KTLASGSADGTVRLWDLATGKLLRT 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 101 vrLQGHEGPVYAVhgiyqSGPSDGEqhaLIASAASDSTVRLWSKKGSevKCLQILKFGDGFVLTVCLStlPDTDapVLAC 180
Cdd:COG2319 158 --LTGHSGAVTSV-----AFSPDGK---LLASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRSVAFS--PDGK--LLAS 221

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 181 GDDGGRIHLF-VQQDdwfQKMLSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLymkptsletEDGSIRlkentf 259
Cdd:COG2319 222 GSADGTVRLWdLATG---KLLRTLTGHSGSVRSVAFSPDGR--LLASGSADGTVRLWDL---------ATGELL------ 281

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 260 tikdggvsttvavileTVLAGHENWVNAIHWQPsfykDGVlhqpvRLLSASMDKTMILWAPDEESgvwleqvRVGEVGGN 339
Cdd:COG2319 282 ----------------RTLTGHSGGVNSVAFSP----DGK-----LLASGSDDGTVRLWDLATGK-------LLRTLTGH 329

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 77628045 340 TLGFYGCQFGENGSMIIAHAFHGAMHLWkqstvNPRQWAPEIVISGHFDGVQDLIWDPEGEFIITTSTDQTTRL 413
Cdd:COG2319 330 TGAVRSVAFSPDGKTLASGSDDGTVRLW-----DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
274-694 3.72e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.90  E-value: 3.72e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 274 LETVLAGHENWVNAIHWQPSfykdgvlhqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYGCQFGENGS 353
Cdd:COG2319  70 LLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRSVAFSPDGK 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 354 MIIAHAFHGAMHLWkqstvNPRQWAPEIVISGHFDGVQDLIWDPEGEFIITTSTDQTTRLfapWkkknqSQVTWHEIARP 433
Cdd:COG2319 134 TLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---W-----DLATGKLLRTL 200

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 434 QIHGYNLKCLAMI-DRFQFVSGADEKVLRVFsaprnfvenfsvisrqslshmlydednDLPEGAtvpalglsnkavfegd 512
Cdd:COG2319 201 TGHTGAVRSVAFSpDGKLLASGSADGTVRLW---------------------------DLATGK---------------- 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 513 mtyltseeeellspafgypqvifqpavlsepptedhllqntlwpEVQKLYGHGYEIFCVTCNNSKTLLASACkaaqkEHA 592
Cdd:COG2319 238 --------------------------------------------LLRTLTGHSGSVRSVAFSPDGRLLASGS-----ADG 268

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 593 AIILWSTTSWKQVQSLAYHTLTVTQMAFSPDDKFLLAVSRDRTWSLWkrqDVTSAEfdpffSLFAFTNkitsvHSRIIWS 672
Cdd:COG2319 269 TVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW---DLATGK-----LLRTLTG-----HTGAVRS 335

                       410       420
                ....*....|....*....|..
gi 77628045 673 CDWSPDSKYFFTGSRDKKVVVW 694
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 561-815 6.08e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.00  E-value: 6.08e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 561 LYGHGYEIFCVTCNNSKTLLASACKAAQkehaaIILWSTTSWKQVQSLAYHTLTVTQMAFSPDDKFLLAVSRDRTWSLWk 640
Cdd:cd00200  47 LKGHTGPVRDVAASADGTYLASGSSDKT-----IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW- 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 641 rqDVTSAEFdpffsLFAFTNkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW----GECNSSYNPMEHPINPCS---- 712
Cdd:cd00200 121 --DVETGKC-----LTTLRG-----HTDWVNSVAFSPDGTFVASSSQDGTIKLWdlrtGKCVATLTGHTGEVNSVAfspd 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 713 -----------SI----LDVGSC----------VTAVSVCPvlnpaQRYIVAVGLESGKICIYswsktnqetkDWTSCVE 767
Cdd:cd00200 189 gekllssssdgTIklwdLSTGKClgtlrghengVNSVAFSP-----DGYLLASGSEDGTIRVW----------DLRTGEC 253

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 77628045 768 TTPSQSHTLGIRRLCWkscsgsteqSEEGTewlDFASCGEDHTVKIYR 815
Cdd:cd00200 254 VQTLSGHTNSVTSLAW---------SPDGK---RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 611-817 4.69e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 4.69e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 611 HTLTVTQMAFSPDDKFLLAVSRDRTWSLWkrqDVTSAEFDpffslfaFTNKitsVHSRIIWSCDWSPDSKYFFTGSRDKK 690
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELL-------RTLK---GHTGPVRDVAASADGTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 691 VVVW----GECNSSYNPMEHPINpcssildvgscvtavsvCPVLNPAQRYIVAvGLESGKICIYSWSKTNQET-----KD 761
Cdd:cd00200  75 IRLWdletGECVRTLTGHTSYVS-----------------SVAFSPDGRILSS-SSRDKTIKVWDVETGKCLTtlrghTD 136

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 77628045 762 WTSCVetTPSQSHTLGirrlcwkscsgsteqseegtewldfASCGEDHTVKIYRVN 817
Cdd:cd00200 137 WVNSV--AFSPDGTFV-------------------------ASSSQDGTIKLWDLR 165
WD40 COG2319
WD40 repeat [General function prediction only];
586-817 8.25e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 8.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 586 AAQKEHAAIILWSTTSWKQVQSLAYHTLTVTQMAFSPDDKFLLAVSRDRTWSLWkrqDVTSAEFDPFFSLfaftnkitsv 665
Cdd:COG2319  52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG---------- 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 666 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW----GECNSSYNPMEHPinpcssildvgscVTAVSVcpvlNPAQRYIvAVG 741
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSADGTVRLWdlatGKLLRTLTGHSGA-------------VTSVAF----SPDGKLL-ASG 180

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 77628045 742 LESGKICIYSWsKTNQETKDWTscvettpsqSHTLGIRRLCWkscsgsteqSEEGTeWLdfASCGEDHTVKIYRVN 817
Cdd:COG2319 181 SDDGTVRLWDL-ATGKLLRTLT---------GHTGAVRSVAF---------SPDGK-LL--ASGSADGTVRLWDLA 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 666-694 1.38e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.38e-05
                           10        20
                   ....*....|....*....|....*....
gi 77628045    666 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 694
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
666-694 2.07e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 2.07e-05
                          10        20
                  ....*....|....*....|....*....
gi 77628045   666 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 694
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
197-236 1.35e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 77628045   197 FQKMLSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 197-236 1.41e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.41e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 77628045    197 FQKMLSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-415 1.22e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.70  E-value: 1.22e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045  54 LNGHTARVNCLHWirtedgSPSTE-LVSGASDNRVIHWELENNQVLKsvRLQGHEGPVYAVHGIyqsgpSDGEQhalIAS 132
Cdd:cd00200   5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLR--TLKGHTGPVRDVAAS-----ADGTY---LAS 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 133 AASDSTVRLWSKKGSEvkCLQILKFGDGFVLTVCLSTlpdtDAPVLACGDDGGRIHLFvqqdDW--FQKMLSLCGHEDWI 210
Cdd:cd00200  69 GSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAFSP----DGRILSSSSRDKTIKVW----DVetGKCLTTLRGHTDWV 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 211 RGVEWATFGRdlFLASCSQDCLIRIWRLymkptsletedGSIRLKentftikdggvsttvavileTVLAGHENWVNAIHW 290
Cdd:cd00200 139 NSVAFSPDGT--FVASSSQDGTIKLWDL-----------RTGKCV--------------------ATLTGHTGEVNSVAF 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 291 QPsfykDGVlhqpvRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYGCQFGENGSMIIAHAFHGAMHLWKQS 370
Cdd:cd00200 186 SP----DGE-----KLLSSSSDGTIKLW--DLSTGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 77628045 371 TVNPRQwapeiVISGHFDGVQDLIWDPEGEFIITTSTDQTTRLFA 415
Cdd:cd00200 250 TGECVQ-----TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
21-413 9.54e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 9.54e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045  21 ALSWNSGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLHWirTEDGspsTELVSGASDNRVIHWELENNQVLKS 100
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF--SPDG---KTLASGSADGTVRLWDLATGKLLRT 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 101 vrLQGHEGPVYAVhgiyqSGPSDGEqhaLIASAASDSTVRLWSKKGSevKCLQILKFGDGFVLTVCLStlPDTDapVLAC 180
Cdd:COG2319 158 --LTGHSGAVTSV-----AFSPDGK---LLASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRSVAFS--PDGK--LLAS 221

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 181 GDDGGRIHLF-VQQDdwfQKMLSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLymkptsletEDGSIRlkentf 259
Cdd:COG2319 222 GSADGTVRLWdLATG---KLLRTLTGHSGSVRSVAFSPDGR--LLASGSADGTVRLWDL---------ATGELL------ 281

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 260 tikdggvsttvavileTVLAGHENWVNAIHWQPsfykDGVlhqpvRLLSASMDKTMILWAPDEESgvwleqvRVGEVGGN 339
Cdd:COG2319 282 ----------------RTLTGHSGGVNSVAFSP----DGK-----LLASGSDDGTVRLWDLATGK-------LLRTLTGH 329

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 77628045 340 TLGFYGCQFGENGSMIIAHAFHGAMHLWkqstvNPRQWAPEIVISGHFDGVQDLIWDPEGEFIITTSTDQTTRL 413
Cdd:COG2319 330 TGAVRSVAFSPDGKTLASGSDDGTVRLW-----DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-319 4.85e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.66  E-value: 4.85e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045  42 LYDPQKKVVITNLNGHTARVNCLHWirtedgSPSTELVSGAS-DNRVIHWELENNQVLKSvrLQGHEGPVYAVHgiyQSG 120
Cdd:cd00200  77 LWDLETGECVRTLTGHTSYVSSVAF------SPDGRILSSSSrDKTIKVWDVETGKCLTT--LRGHTDWVNSVA---FSP 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 121 PSDgeqhaLIASAASDSTVRLWSKKGSevKCLQILKFGDGFVLTVCLStlpDTDAPVLACGDDgGRIHLFVQQDDWFQKm 200
Cdd:cd00200 146 DGT-----FVASSSQDGTIKLWDLRTG--KCVATLTGHTGEVNSVAFS---PDGEKLLSSSSD-GTIKLWDLSTGKCLG- 213

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 201 lSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLYMKPTSletedgsirlkentftikdggvsttvavileTVLAG 280
Cdd:cd00200 214 -TLRGHENGVNSVAFSPDGY--LLASGSEDGTIRVWDLRTGECV-------------------------------QTLSG 259

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 77628045 281 HENWVNAIHWQPSfykdgvlhqPVRLLSASMDKTMILWA 319
Cdd:cd00200 260 HTNSVTSLAWSPD---------GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
29-318 1.64e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 1.64e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045  29 GGLLAFGTS-CSVVLYDPQKKVVITNLNGHTARVNCLHWirtedgSP-STELVSGASDNRVIHWELENNQVLKSvrLQGH 106
Cdd:COG2319 132 GKTLASGSAdGTVRLWDLATGKLLRTLTGHSGAVTSVAF------SPdGKLLASGSDDGTVRLWDLATGKLLRT--LTGH 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 107 EGPVYAVhgiyQSGPsDGEqhaLIASAASDSTVRLWSKKGSevKCLQILKFGDGFVLTVCLSTlpdtDAPVLACGDDGGR 186
Cdd:COG2319 204 TGAVRSV----AFSP-DGK---LLASGSADGTVRLWDLATG--KLLRTLTGHSGSVRSVAFSP----DGRLLASGSADGT 269

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 187 IHLFvqQDDWFQKMLSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRL------------YMKPTSLE-------- 246
Cdd:COG2319 270 VRLW--DLATGELLRTLTGHSGGVNSVAFSPDGK--LLASGSDDGTVRLWDLatgkllrtltghTGAVRSVAfspdgktl 345

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 77628045 247 ---TEDGSIRLkentFTIKDGGVSTTvaviletvLAGHENWVNAIHWQPsfykDGVlhqpvRLLSASMDKTMILW 318
Cdd:COG2319 346 asgSDDGTVRL----WDLATGELLRT--------LTGHTGAVTSVAFSP----DGR-----TLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-237 7.59e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 7.59e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045   9 SYVFCCpnrargalSWNsgPGGLLAFGTS--CSVVLYDPQKKVVITNLNGHTARVNCLHWirtedgSPSTELVSGASDNR 86
Cdd:cd00200  94 SYVSSV--------AFS--PDGRILSSSSrdKTIKVWDVETGKCLTTLRGHTDWVNSVAF------SPDGTFVASSSQDG 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045  87 VIH-WELENNQVLKsvRLQGHEGPVYAVHgiyqsgPSDGEQHalIASAASDSTVRLWSKkgSEVKCLQILKFGDGFVLTV 165
Cdd:cd00200 158 TIKlWDLRTGKCVA--TLTGHTGEVNSVA------FSPDGEK--LLSSSSDGTIKLWDL--STGKCLGTLRGHENGVNSV 225

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 77628045 166 CLStlPDTDapVLACGDDGGRIHLFvqQDDWFQKMLSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWR 237
Cdd:cd00200 226 AFS--PDGY--LLASGSEDGTIRVW--DLRTGECVQTLSGHTNSVTSLAWSPDGK--RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
17-465 1.06e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 1.06e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045  17 RARGALSWNSGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLHWIrtedgSPSTELVSGASDNRVIHWELENNQ 96
Cdd:COG2319  37 AAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-----PDGRLLASASADGTVRLWDLATGL 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045  97 VLksVRLQGHEGPVYAVhgiyQSGPsDGEqhaLIASAASDSTVRLWSKKGSevKCLQILKFGDGFVLTVCLStlPDTDap 176
Cdd:COG2319 112 LL--RTLTGHTGAVRSV----AFSP-DGK---TLASGSADGTVRLWDLATG--KLLRTLTGHSGAVTSVAFS--PDGK-- 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 177 VLACGDDGGRIHLFVQQDDwfQKMLSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLymkptsletEDGSIRlke 256
Cdd:COG2319 176 LLASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRSVAFSPDGK--LLASGSADGTVRLWDL---------ATGKLL--- 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 257 ntftikdggvsttvavileTVLAGHENWVNAIHWQPsfykDGVlhqpvRLLSASMDKTMILWapdeesgvwleqvrvgev 336
Cdd:COG2319 240 -------------------RTLTGHSGSVRSVAFSP----DGR-----LLASGSADGTVRLW------------------ 273

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 337 ggntlgfygcqfgengsmiiahafhgamhlwkqstvNPRQWAPEIVISGHFDGVQDLIWDPEGEFIITTSTDQTTRLfap 416
Cdd:COG2319 274 ------------------------------------DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL--- 314

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|
gi 77628045 417 WKKKnqsqvTWHEIARPQIHGYNLKCLAMI-DRFQFVSGADEKVLRVFSA 465
Cdd:COG2319 315 WDLA-----TGKLLRTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
274-694 3.72e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.90  E-value: 3.72e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 274 LETVLAGHENWVNAIHWQPSfykdgvlhqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYGCQFGENGS 353
Cdd:COG2319  70 LLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRSVAFSPDGK 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 354 MIIAHAFHGAMHLWkqstvNPRQWAPEIVISGHFDGVQDLIWDPEGEFIITTSTDQTTRLfapWkkknqSQVTWHEIARP 433
Cdd:COG2319 134 TLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---W-----DLATGKLLRTL 200

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 434 QIHGYNLKCLAMI-DRFQFVSGADEKVLRVFsaprnfvenfsvisrqslshmlydednDLPEGAtvpalglsnkavfegd 512
Cdd:COG2319 201 TGHTGAVRSVAFSpDGKLLASGSADGTVRLW---------------------------DLATGK---------------- 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 513 mtyltseeeellspafgypqvifqpavlsepptedhllqntlwpEVQKLYGHGYEIFCVTCNNSKTLLASACkaaqkEHA 592
Cdd:COG2319 238 --------------------------------------------LLRTLTGHSGSVRSVAFSPDGRLLASGS-----ADG 268

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 593 AIILWSTTSWKQVQSLAYHTLTVTQMAFSPDDKFLLAVSRDRTWSLWkrqDVTSAEfdpffSLFAFTNkitsvHSRIIWS 672
Cdd:COG2319 269 TVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW---DLATGK-----LLRTLTG-----HTGAVRS 335

                       410       420
                ....*....|....*....|..
gi 77628045 673 CDWSPDSKYFFTGSRDKKVVVW 694
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
21-238 4.06e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.44  E-value: 4.06e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045  21 ALSWnSGPGGLLAFGTS-CSVVLYDPQKKVVITNLNGHTARVNCLHWirTEDGspsTELVSGASDNRVIHWELENNQVLK 99
Cdd:COG2319 209 SVAF-SPDGKLLASGSAdGTVRLWDLATGKLLRTLTGHSGSVRSVAF--SPDG---RLLASGSADGTVRLWDLATGELLR 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 100 svRLQGHEGPVYAVHgiyqsgPS-DGEqhaLIASAASDSTVRLWSKKGSevKCLQILKFGDGFVLTVCLStlPDTDapVL 178
Cdd:COG2319 283 --TLTGHSGGVNSVA------FSpDGK---LLASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRSVAFS--PDGK--TL 345

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 77628045 179 ACGDDGGRIHLfvqqddW----FQKMLSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRL 238
Cdd:COG2319 346 ASGSDDGTVRL------WdlatGELLRTLTGHTGAVTSVAFSPDGR--TLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
554-817 3.75e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 3.75e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 554 LW-----PEVQKLYGHGYEIFCVTCNNSKTLLASACkaaqkEHAAIILWSTTSWKQVQSLAYHTLTVTQMAFSPDDKFLL 628
Cdd:COG2319 188 LWdlatgKLLRTLTGHTGAVRSVAFSPDGKLLASGS-----ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 629 AVSRDRTWSLWkrqDVTSAEFDPFFslfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVW----GECNSSYNPM 704
Cdd:COG2319 263 SGSADGTVRLW---DLATGELLRTL----------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWdlatGKLLRTLTGH 329

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 705 EHPinpcssildvgscVTAVsvcpVLNPAQRYIVAVGlESGKICIYswsktnqetkDWTSCVETTPSQSHTLGIRRLCWk 784
Cdd:COG2319 330 TGA-------------VRSV----AFSPDGKTLASGS-DDGTVRLW----------DLATGELLRTLTGHTGAVTSVAF- 380

                       250       260       270
                ....*....|....*....|....*....|...
gi 77628045 785 SCSGSTeqseegtewldFASCGEDHTVKIYRVN 817
Cdd:COG2319 381 SPDGRT-----------LASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
554-817 8.10e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 8.10e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 554 LW-----PEVQKLYGHGYEIFCVTCNNSKTLLASACKAAQkehaaIILWSTTSWKQVQSLAYHTLTVTQMAFSPDDKFLL 628
Cdd:COG2319 146 LWdlatgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 629 AVSRDRTWSLWkrqDVTSAEFdpffsLFAFTNkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW----GECNSSYnpm 704
Cdd:COG2319 221 SGSADGTVRLW---DLATGKL-----LRTLTG-----HSGSVRSVAFSPDGRLLASGSADGTVRLWdlatGELLRTL--- 284

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 705 EHPINPcssildvgscVTAVSVcpvlNPAQRYIVAVGlESGKICIYSWSkTNQETKDWTScvettpsqsHTLGIRRLCWk 784
Cdd:COG2319 285 TGHSGG----------VNSVAF----SPDGKLLASGS-DDGTVRLWDLA-TGKLLRTLTG---------HTGAVRSVAF- 338

                       250       260       270
                ....*....|....*....|....*....|...
gi 77628045 785 scsgsteqSEEGtEWLdfASCGEDHTVKIYRVN 817
Cdd:COG2319 339 --------SPDG-KTL--ASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
557-817 1.04e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 1.04e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 557 EVQKLYGHGYEIFCVTCNNSKTLLASACkaaqkEHAAIILWSTTSWKQVQSLAYHTLTVTQMAFSPDDKFLLAVSRDRTW 636
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKTLASGS-----ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 637 SLWkrqDVTSAEFdpffsLFAFTNkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW----GECNSSYNPmeHpinpcs 712
Cdd:COG2319 187 RLW---DLATGKL-----LRTLTG-----HTGAVRSVAFSPDGKLLASGSADGTVRLWdlatGKLLRTLTG--H------ 245

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 713 sildvGSCVTAVSVCPvlnpaQRYIVAVGLESGKICIYswsktnqetkDWTSCVETTPSQSHTLGIRRLCWkscsgsteq 792
Cdd:COG2319 246 -----SGSVRSVAFSP-----DGRLLASGSADGTVRLW----------DLATGELLRTLTGHSGGVNSVAF--------- 296

                       250       260
                ....*....|....*....|....*
gi 77628045 793 SEEGTeWLdfASCGEDHTVKIYRVN 817
Cdd:COG2319 297 SPDGK-LL--ASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 561-815 6.08e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.00  E-value: 6.08e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 561 LYGHGYEIFCVTCNNSKTLLASACKAAQkehaaIILWSTTSWKQVQSLAYHTLTVTQMAFSPDDKFLLAVSRDRTWSLWk 640
Cdd:cd00200  47 LKGHTGPVRDVAASADGTYLASGSSDKT-----IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW- 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 641 rqDVTSAEFdpffsLFAFTNkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW----GECNSSYNPMEHPINPCS---- 712
Cdd:cd00200 121 --DVETGKC-----LTTLRG-----HTDWVNSVAFSPDGTFVASSSQDGTIKLWdlrtGKCVATLTGHTGEVNSVAfspd 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 713 -----------SI----LDVGSC----------VTAVSVCPvlnpaQRYIVAVGLESGKICIYswsktnqetkDWTSCVE 767
Cdd:cd00200 189 gekllssssdgTIklwdLSTGKClgtlrghengVNSVAFSP-----DGYLLASGSEDGTIRVW----------DLRTGEC 253

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 77628045 768 TTPSQSHTLGIRRLCWkscsgsteqSEEGTewlDFASCGEDHTVKIYR 815
Cdd:cd00200 254 VQTLSGHTNSVTSLAW---------SPDGK---RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 205-694 3.88e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 3.88e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 205 GHEDWIRGVEWATFGRdlFLASCSQDCLIRIWrlymkptSLETEDgsirlkentftikdggvsttvaviLETVLAGHENW 284
Cdd:cd00200   7 GHTGGVTCVAFSPDGK--LLATGSGDGTIKVW-------DLETGE------------------------LLRTLKGHTGP 53

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 285 VNAIHWQPSFYKdgvlhqpvrLLSASMDKTMILWapDEESGVwleqvRVGEVGGNTLGFYGCQFGENGSMIIAHAFHGAM 364
Cdd:cd00200  54 VRDVAASADGTY---------LASGSSDKTIRLW--DLETGE-----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI 117

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 365 HLWKQSTVNPRQwapeiVISGHFDGVQDLIWDPEGEFIITTSTDQTTRLFAPwkkknqsqvtwheiarpqihgYNLKCla 444
Cdd:cd00200 118 KVWDVETGKCLT-----TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL---------------------RTGKC-- 169

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 445 midrfqfvsgadekvlrvfsaprnfvenfsvisrqslshmlydedndlpegatvpalglsnkavfegdmtyltseeeell 524
Cdd:cd00200     --------------------------------------------------------------------------------

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 525 spafgypqvifqpavlsepptedhllqntlwpeVQKLYGHGYEIFCVTCNNSKTLLASACKAAQkehaaIILWSTTSWKQ 604
Cdd:cd00200 170 ---------------------------------VATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-----IKLWDLSTGKC 211

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 605 VQSLAYHTLTVTQMAFSPDDKFLLAVSRDRT---WSLWKRQDVtsaefdpffslfaftnKITSVHSRIIWSCDWSPDSKY 681
Cdd:cd00200 212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTirvWDLRTGECV----------------QTLSGHTNSVTSLAWSPDGKR 275

                       490
                ....*....|...
gi 77628045 682 FFTGSRDKKVVVW 694
Cdd:cd00200 276 LASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
549-817 8.16e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.26  E-value: 8.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 549 LLQNTLWPEVQKLYGHGYEIFCVTCNNSKTLLASACkaaqkEHAAIILWSTTSWKQVQSLAYHTLTVTQMAFSPDDKFLL 628
Cdd:COG2319  62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS-----ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLA 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 629 AVSRDRTWSLWkrqDVTSAEFdpffsLFAFTNkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW----GECNSSYNpm 704
Cdd:COG2319 137 SGSADGTVRLW---DLATGKL-----LRTLTG-----HSGAVTSVAFSPDGKLLASGSDDGTVRLWdlatGKLLRTLT-- 201

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 705 EHPinpcssildvgSCVTAVSVcpvlNPAQRYIvAVGLESGKICIYswsktnqetkDWTSCVETTPSQSHTLGIRRLCWk 784
Cdd:COG2319 202 GHT-----------GAVRSVAF----SPDGKLL-ASGSADGTVRLW----------DLATGKLLRTLTGHSGSVRSVAF- 254

                       250       260       270
                ....*....|....*....|....*....|...
gi 77628045 785 scsgsteqSEEGTeWLdfASCGEDHTVKIYRVN 817
Cdd:COG2319 255 --------SPDGR-LL--ASGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 611-817 4.69e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 4.69e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 611 HTLTVTQMAFSPDDKFLLAVSRDRTWSLWkrqDVTSAEFDpffslfaFTNKitsVHSRIIWSCDWSPDSKYFFTGSRDKK 690
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELL-------RTLK---GHTGPVRDVAASADGTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 691 VVVW----GECNSSYNPMEHPINpcssildvgscvtavsvCPVLNPAQRYIVAvGLESGKICIYSWSKTNQET-----KD 761
Cdd:cd00200  75 IRLWdletGECVRTLTGHTSYVS-----------------SVAFSPDGRILSS-SSRDKTIKVWDVETGKCLTtlrghTD 136

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 77628045 762 WTSCVetTPSQSHTLGirrlcwkscsgsteqseegtewldfASCGEDHTVKIYRVN 817
Cdd:cd00200 137 WVNSV--AFSPDGTFV-------------------------ASSSQDGTIKLWDLR 165
WD40 COG2319
WD40 repeat [General function prediction only];
586-817 8.25e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 8.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 586 AAQKEHAAIILWSTTSWKQVQSLAYHTLTVTQMAFSPDDKFLLAVSRDRTWSLWkrqDVTSAEFDPFFSLfaftnkitsv 665
Cdd:COG2319  52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG---------- 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 666 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW----GECNSSYNPMEHPinpcssildvgscVTAVSVcpvlNPAQRYIvAVG 741
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSADGTVRLWdlatGKLLRTLTGHSGA-------------VTSVAF----SPDGKLL-ASG 180

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 77628045 742 LESGKICIYSWsKTNQETKDWTscvettpsqSHTLGIRRLCWkscsgsteqSEEGTeWLdfASCGEDHTVKIYRVN 817
Cdd:COG2319 181 SDDGTVRLWDL-ATGKLLRTLT---------GHTGAVRSVAF---------SPDGK-LL--ASGSADGTVRLWDLA 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 666-694 1.38e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.38e-05
                           10        20
                   ....*....|....*....|....*....
gi 77628045    666 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 694
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
666-694 2.07e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 2.07e-05
                          10        20
                  ....*....|....*....|....*....
gi 77628045   666 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 694
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 601-640 2.21e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 2.21e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 77628045    601 SWKQVQSLAYHTLTVTQMAFSPDDKFLLAVSRDRTWSLWK 640
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 666-814 8.61e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 8.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 666 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW----GECNSSYNPMEHPINPCSSILDVGSCVTA-----VSV---------- 726
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWdletGELLRTLKGHTGPVRDVAASADGTYLASGssdktIRLwdletgecvr 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 727 ----------CPVLNPAQRYIVAvGLESGKICIYSWSKTNQET-----KDWTSCVETTPSQS------------------ 773
Cdd:cd00200  88 tltghtsyvsSVAFSPDGRILSS-SSRDKTIKVWDVETGKCLTtlrghTDWVNSVAFSPDGTfvasssqdgtiklwdlrt 166

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 77628045 774 ---------HTLGIRRLCWkscsgsteqSEEGTEwldFASCGEDHTVKIY 814
Cdd:cd00200 167 gkcvatltgHTGEVNSVAF---------SPDGEK---LLSSSSDGTIKLW 204
WD40 pfam00400
WD domain, G-beta repeat;
602-639 1.80e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.80e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 77628045   602 WKQVQSLAYHTLTVTQMAFSPDDKFLLAVSRDRTWSLW 639
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
197-236 1.35e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 77628045   197 FQKMLSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 197-236 1.41e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.41e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 77628045    197 FQKMLSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLW 39
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
178-327 3.25e-03

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 40.78  E-value: 3.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 178 LACGDDGGRIHLFVQQDDW---------FQKM------LSLCGHEDWIRGVEWAT-FGRDLFLAScSQDCLIRIWRLYMK 241
Cdd:COG5170  41 LATGDKGGRVVLFEREKSYgceykffteFQSHelefdyLKSLEIEEKINAIEWFDdTGRNHFLLS-TNDKTIKLWKIYEK 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77628045 242 PTSLETEDGSirlkENTFTIKDGGVSTTVAVILETVLAGHENWVNAihwQPSFYKDGVLHQPVRLLSASMDKTMILWAPD 321
Cdd:COG5170 120 NLKVVAENNL----SDSFHSPMGGPLTSTKELLLPRLSEHDEIIAA---KPCRVYANAHPYHINSISFNSDKETLLSADD 192


                ....*.
gi 77628045 322 EESGVW 327
Cdd:COG5170 193 LRINLW 198
WD40 COG2319
WD40 repeat [General function prediction only];
29-94 6.45e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 6.45e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77628045  29 GGLLAFGTS-CSVVLYDPQKKVVITNLNGHTARVNCLHWirTEDGspsTELVSGASDNRVIHWELEN 94
Cdd:COG2319 342 GKTLASGSDdGTVRLWDLATGELLRTLTGHTGAVTSVAF--SPDG---RTLASGSADGTVRLWDLAT 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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