NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|77020283|ref|NP_001029146|]
View 

alpha-endosulfine isoform 1 [Rattus norvegicus]

Protein Classification

endosulfine family protein( domain architecture ID 7824)

endosulfine family protein similar to Homo sapiens alpha-endosulfine and cAMP-regulated phosphoprotein 19, which are protein phosphatase inhibitor that specifically inhibit protein phosphatase 2A (PP2A) during mitosis

Gene Ontology:  GO:0051301|GO:0019888|GO:0000278|GO:0005102|GO:0004864|GO:0051721

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Endosulfine super family cl08423
cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both ...
 33-86 2.72e-05

cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19. Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism. In both cases the region occupies the majority of the protein.


The actual alignment was detected with superfamily member pfam04667:

Pssm-ID: 398375  Cd Length: 80  Bit Score: 39.60  E-value: 2.72e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 77020283    33 EEAKLKAKYpslGQKPGGSDFLMKRLQKgQKYFDSGDYNMAKAKMKNKQLPSAG 86
Cdd:pfam04667   8 EELKLYKKY---GKLPKKKDLLSKKLQE-RKYFDSGDYALSKAGVKKSQKSPGG 57
 
Name Accession Description Interval E-value
Endosulfine pfam04667
cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both ...
 33-86 2.72e-05

cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19. Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism. In both cases the region occupies the majority of the protein.


Pssm-ID: 398375  Cd Length: 80  Bit Score: 39.60  E-value: 2.72e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 77020283    33 EEAKLKAKYpslGQKPGGSDFLMKRLQKgQKYFDSGDYNMAKAKMKNKQLPSAG 86
Cdd:pfam04667   8 EELKLYKKY---GKLPKKKDLLSKKLQE-RKYFDSGDYALSKAGVKKSQKSPGG 57
 
Name Accession Description Interval E-value
Endosulfine pfam04667
cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both ...
 33-86 2.72e-05

cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19. Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism. In both cases the region occupies the majority of the protein.


Pssm-ID: 398375  Cd Length: 80  Bit Score: 39.60  E-value: 2.72e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 77020283    33 EEAKLKAKYpslGQKPGGSDFLMKRLQKgQKYFDSGDYNMAKAKMKNKQLPSAG 86
Cdd:pfam04667   8 EELKLYKKY---GKLPKKKDLLSKKLQE-RKYFDSGDYALSKAGVKKSQKSPGG 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH