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Conserved domains on  [gi|71834540|ref|NP_001025370|]
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diamine acetyltransferase 1a.1 [Danio rerio]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11441181)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
3-153 1.39e-19

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


:

Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 80.42  E-value: 1.39e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71834540   3 SYILRKAEPKDVSDILRLIKE-----LAKFEEMEDQViltekDLLEDGFGDH--PFYHCMVAEvakqhqsaDGHVIVGFA 75
Cdd:COG1247   1 EMTIRPATPEDAPAIAAIYNEaiaegTATFETEPPSE-----EEREAWFAAIlaPGRPVLVAE--------EDGEVVGFA 67

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71834540  76 mYYFTYDPWIG-KLLYLEDFYVMKEYRGFGIGSEILKKLSQTAVRTRCSSMHFIVAEWNTTSIEFYKRRGASDLSHEEG 153
Cdd:COG1247  68 -SLGPFRPRPAyRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTLPE 145
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
3-153 1.39e-19

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 80.42  E-value: 1.39e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71834540   3 SYILRKAEPKDVSDILRLIKE-----LAKFEEMEDQViltekDLLEDGFGDH--PFYHCMVAEvakqhqsaDGHVIVGFA 75
Cdd:COG1247   1 EMTIRPATPEDAPAIAAIYNEaiaegTATFETEPPSE-----EEREAWFAAIlaPGRPVLVAE--------EDGEVVGFA 67

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71834540  76 mYYFTYDPWIG-KLLYLEDFYVMKEYRGFGIGSEILKKLSQTAVRTRCSSMHFIVAEWNTTSIEFYKRRGASDLSHEEG 153
Cdd:COG1247  68 -SLGPFRPRPAyRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTLPE 145
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 36-144 3.45e-14

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 65.23  E-value: 3.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71834540    36 LTEKDLLEDGFGDHPFYHCMVAEvakqhqsaDGHVIVGFAMYYFTYDPWigKLLYLEDFYVMKEYRGFGIGSEILKKLSQ 115
Cdd:pfam00583  17 PDEPLDLLEDWDEDASEGFFVAE--------EDGELVGFASLSIIDDEP--PVGEIEGLAVAPEYRGKGIGTALLQALLE 86

                          90       100
                  ....*....|....*....|....*....
gi 71834540   116 TAVRTRCSSMHFIVAEWNTTSIEFYKRRG 144
Cdd:pfam00583  87 WARERGCERIFLEVAADNLAAIALYEKLG 115
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 67-126 4.39e-08

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 47.66  E-value: 4.39e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71834540  67 DGHVIVGFAMYYFtyDPWIGKLLYLEDFYVMKEYRGFGIGSEILKKLSQTAVRTRCSSMH 126
Cdd:cd04301   6 DDGEIVGFASLSP--DGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLR 63
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
3-153 1.39e-19

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 80.42  E-value: 1.39e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71834540   3 SYILRKAEPKDVSDILRLIKE-----LAKFEEMEDQViltekDLLEDGFGDH--PFYHCMVAEvakqhqsaDGHVIVGFA 75
Cdd:COG1247   1 EMTIRPATPEDAPAIAAIYNEaiaegTATFETEPPSE-----EEREAWFAAIlaPGRPVLVAE--------EDGEVVGFA 67

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71834540  76 mYYFTYDPWIG-KLLYLEDFYVMKEYRGFGIGSEILKKLSQTAVRTRCSSMHFIVAEWNTTSIEFYKRRGASDLSHEEG 153
Cdd:COG1247  68 -SLGPFRPRPAyRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTLPE 145
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 36-144 3.45e-14

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 65.23  E-value: 3.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71834540    36 LTEKDLLEDGFGDHPFYHCMVAEvakqhqsaDGHVIVGFAMYYFTYDPWigKLLYLEDFYVMKEYRGFGIGSEILKKLSQ 115
Cdd:pfam00583  17 PDEPLDLLEDWDEDASEGFFVAE--------EDGELVGFASLSIIDDEP--PVGEIEGLAVAPEYRGKGIGTALLQALLE 86

                          90       100
                  ....*....|....*....|....*....
gi 71834540   116 TAVRTRCSSMHFIVAEWNTTSIEFYKRRG 144
Cdd:pfam00583  87 WARERGCERIFLEVAADNLAAIALYEKLG 115
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
6-144 6.40e-13

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 62.41  E-value: 6.40e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71834540   6 LRKAEPKDVSDILRLIKELakFEEMEdqviltEKDLLEDGFGDHPFYHCMVAEvakqhqsaDGHVIVGFAMYYFTYDPWI 85
Cdd:COG3153   1 IRPATPEDAEAIAALLRAA--FGPGR------EAELVDRLREDPAAGLSLVAE--------DDGEIVGHVALSPVDIDGE 64

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 71834540  86 GKLLYLEDFYVMKEYRGFGIGSEILKKLSQTAVRTRCSsmhFIVAEWNTTSIEFYKRRG 144
Cdd:COG3153  65 GPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGAR---AVVLLGDPSLLPFYERFG 120
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 73-144 6.90e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 61.21  E-value: 6.90e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71834540  73 GFAMYYFTYDPWIGkllYLEDFYVMKEYRGFGIGSEILKKLSQTAVRTRCSSMHFIVAEWNTTSIEFYKRRG 144
Cdd:COG0456   1 GFALLGLVDGGDEA---EIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLG 69
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 4-159 6.52e-11

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 56.99  E-value: 6.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71834540   4 YILRKAEPKDvsdilrlIKELAKFEEMEDQVILTEKDLLEdgfgdhpfYHCMVAEVAKQhqsadghvIVGFAMYyFTYDP 83
Cdd:COG0454   1 MSIRKATPED-------INFILLIEALDAELKAMEGSLAG--------AEFIAVDDKGE--------PIGFAGL-RRLDD 56

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71834540  84 WIGkllYLEDFYVMKEYRGFGIGSEILKKLSQTAVRTRCSSMHFIVAEWNTTSIEFYKRRGASDLSHEEGWRLFKI 159
Cdd:COG0454  57 KVL---ELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRFYERLGFKEIERYVAYVGGEF 129
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 4-144 1.09e-10

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 56.15  E-value: 1.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71834540   4 YILRKAEPKDVSDILRLIKELAkfeemedqviltekdlLEDGFGDhpFYhcmVAEvakqhqsaDGHVIVGFAMYYftydP 83
Cdd:COG1246   1 MTIRPATPDDVPAILELIRPYA----------------LEEEIGE--FW---VAE--------EDGEIVGCAALH----P 47

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71834540  84 WIGKLLYLEDFYVMKEYRGFGIGSEILKKLSQTAVRTRCSSMHFIVaewNTTSIEFYKRRG 144
Cdd:COG1246  48 LDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLT---TSAAIHFYEKLG 105
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 67-126 4.39e-08

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 47.66  E-value: 4.39e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71834540  67 DGHVIVGFAMYYFtyDPWIGKLLYLEDFYVMKEYRGFGIGSEILKKLSQTAVRTRCSSMH 126
Cdd:cd04301   6 DDGEIVGFASLSP--DGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLR 63
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 50-144 5.82e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 47.83  E-value: 5.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71834540    50 PFYHCMVAEvakqhqsaDGHVIVGFAMYYFTYDPWIGKLLYLedfYVMKEYRGFGIGSEILKKLSQTAVRTRCssmHFIV 129
Cdd:pfam13508   1 PGGRFFVAE--------DDGKIVGFAALLPLDDEGALAELRL---AVHPEYRGQGIGRALLEAAEAAAKEGGI---KLLE 66

                          90
                  ....*....|....*
gi 71834540   130 AEWNTTSIEFYKRRG 144
Cdd:pfam13508  67 LETTNRAAAFYEKLG 81
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
71-144 6.22e-06

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 42.59  E-value: 6.22e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71834540  71 IVGFAMYYftydPWIGKLLYLEDFYVMKEYRGFGIGSEILKKLSQTAVRTRCSSMHFIVAEWNTTSIEFYKRRG 144
Cdd:COG3393   2 LVAMAGVR----AESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLG 71
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 5-142 1.80e-03

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 37.29  E-value: 1.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71834540   5 ILRKAEPKDVSDILRLI--KELAKFEEMEDQVILTEKDLLE---DGFGDHPFYHCMVAEvakqhqsADGHVIVGFAMYYf 79
Cdd:COG1670   9 RLRPLRPEDAEALAELLndPEVARYLPGPPYSLEEARAWLErllADWADGGALPFAIED-------KEDGELIGVVGLY- 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71834540  80 tYDPWIGKLLYLeDFYVMKEYRGFGIGSEILKKLSQTAVRT-RCSSMHFIVAEWNTTSIEFYKR 142
Cdd:COG1670  81 -DIDRANRSAEI-GYWLAPAYWGKGYATEALRALLDYAFEElGLHRVEAEVDPDNTASIRVLEK 142
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 48-144 4.49e-03

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 35.32  E-value: 4.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71834540    48 DHPFYHCMVAEVAKQhqsadghvIVGFAMyyfTYDPWigkllYLEDFYVMKEYRGFGIGSEILKKLSQTAVRTRCSSMHF 127
Cdd:pfam13673  27 DQGEYFFFVAFEGGQ--------IVGVIA---LRDRG-----HISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSEL 90

                          90
                  ....*....|....*..
gi 71834540   128 IVAEwNTTSIEFYKRRG 144
Cdd:pfam13673  91 TVNA-SPYAVPFYEKLG 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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