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Conserved domains on  [gi|71989021|ref|NP_001024615|]
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Delta-like protein [Caenorhabditis elegans]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 10637126)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DSL smart00051
delta serrate ligand;
107-171 8.41e-20

delta serrate ligand;


:

Pssm-ID: 128366  Cd Length: 63  Bit Score: 81.99  E-value: 8.41e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71989021    107 WNTGLPIVIETtlgfNVTVHLRNVCTSNYYGKRCNRYCIPS--PALHWECSTNGVRQCAVGWYGDDC 171
Cdd:smart00051   1 WSTDLHIGGRT----FLEYQIRVTCDENYYGEGCNKFCRPRddFFGHYTCDENGNKGCLEGWMGPYC 63
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
174-208 3.87e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 3.87e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 71989021 174 NIKFCSHQNPCANGGVCS---TDYKCQCPSEFLGPRCE 208
Cdd:cd00054   1 DIDECASGNPCQNGGTCVntvGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
DSL smart00051
delta serrate ligand;
107-171 8.41e-20

delta serrate ligand;


Pssm-ID: 128366  Cd Length: 63  Bit Score: 81.99  E-value: 8.41e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71989021    107 WNTGLPIVIETtlgfNVTVHLRNVCTSNYYGKRCNRYCIPS--PALHWECSTNGVRQCAVGWYGDDC 171
Cdd:smart00051   1 WSTDLHIGGRT----FLEYQIRVTCDENYYGEGCNKFCRPRddFFGHYTCDENGNKGCLEGWMGPYC 63
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
131-172 5.04e-10

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 54.17  E-value: 5.04e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 71989021   131 CTSNYYGKRCNRYCIPSPAL--HWECSTNGVRQCAVGWYGDDCS 172
Cdd:pfam01414   1 CDENYYGSTCSKFCRPRDDKfgHYTCDANGNKVCLPGWTGPYCD 44
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
174-208 3.87e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 3.87e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 71989021 174 NIKFCSHQNPCANGGVCS---TDYKCQCPSEFLGPRCE 208
Cdd:cd00054   1 DIDECASGNPCQNGGTCVntvGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
DSL smart00051
delta serrate ligand;
107-171 8.41e-20

delta serrate ligand;


Pssm-ID: 128366  Cd Length: 63  Bit Score: 81.99  E-value: 8.41e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71989021    107 WNTGLPIVIETtlgfNVTVHLRNVCTSNYYGKRCNRYCIPS--PALHWECSTNGVRQCAVGWYGDDC 171
Cdd:smart00051   1 WSTDLHIGGRT----FLEYQIRVTCDENYYGEGCNKFCRPRddFFGHYTCDENGNKGCLEGWMGPYC 63
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
131-172 5.04e-10

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 54.17  E-value: 5.04e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 71989021   131 CTSNYYGKRCNRYCIPSPAL--HWECSTNGVRQCAVGWYGDDCS 172
Cdd:pfam01414   1 CDENYYGSTCSKFCRPRDDKfgHYTCDANGNKVCLPGWTGPYCD 44
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
174-208 3.87e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 3.87e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 71989021 174 NIKFCSHQNPCANGGVCS---TDYKCQCPSEFLGPRCE 208
Cdd:cd00054   1 DIDECASGNPCQNGGTCVntvGSYRCSCPPGYTGRNCE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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