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Conserved domains on  [gi|71991121|ref|NP_001023278|]
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Suppressor of hairless protein homolog [Caenorhabditis elegans]

Protein Classification

LAG1-DNAbind and BTD domain-containing protein( domain architecture ID 10558086)

protein containing domains LAG1-DNAbind, BTD, and IPT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTD pfam09270
Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a ...
 409-534 1.01e-76

Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR).


:

Pssm-ID: 462734  Cd Length: 123  Bit Score: 241.08  E-value: 1.01e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121   409 EGNAFHASSTKWGAFTIHLFDDERGLQEtdNFAVRDGFVYYGSVVKLVDSVTGIALPRLRIRKVDKQQVILDAscsEEPV 488
Cdd:pfam09270   1 EGGAFHASSTQWGAFTIHLLDDNQGEQE--NFTVRDGFICYGSVVKLVCSVTGVALPPLIIRKVDKQQVILDA---DEPV 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 71991121   489 SQLHKCAFQMIDNELVYLCLSHDKIIQHQATAI--NEHRHQINDGAAW 534
Cdd:pfam09270  76 SQLHKCAFQMKDTERMYLCLSQEKIIQFQATPCpkDPNREVLNDGACW 123
LAG1-DNAbind pfam09271
LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical ...
 215-378 1.29e-64

LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding. This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins.


:

Pssm-ID: 462735  Cd Length: 148  Bit Score: 209.86  E-value: 1.29e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121   215 ISIFHAKVAQKSYGNEKRFFCPPPCIYLIGQGWKLKKdrvaQLYKTLKASAQKDAAIENDPIHEQQATELVAYIGIGSDT 294
Cdd:pfam09271   1 VIILHAKVAQKSYGTEKRFLCPPPCVYLLGPGWKTKS----TALSPDNPLTAPRVTISISGEDSAEESQCIAWIGMIGST 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121   295 SERQqldfstgkvrhpgDQRQDPNIYDYCAAKTLYISDSD-KRKYFDLNAQFFYGCGMEIGGFVSQRIKVISKPSKKKQS 373
Cdd:pfam09271  77 SDQE-------------TQQLDLVVWGRCAAKTLYISDSDeKRKHFELLVKLFAPNGQEIGSFESKPIKVISKPSKKRQS 143


                  ....*
gi 71991121   374 MKNTD 378
Cdd:pfam09271 144 LKNAD 148
IPT super family cl15674
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 556-658 1.48e-54

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


The actual alignment was detected with superfamily member cd01176:

Pssm-ID: 472823  Cd Length: 97  Bit Score: 181.50  E-value: 1.48e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121 556 PISPCPVVGSLEVDGHGEASRVELHGRDFKPNLKVWFGATPVETTFRSEESLHCSIPPVSQVRNEQTHwmftnrTTGDVE 635
Cdd:cd01176   1 PVTPVPVVSSLELNGGGDVAMLELHGENFTPNLKVWFGDVEAETMYRCEESLLCVVPDISAFREEWRW------VRQPVQ 74

                        90       100
                ....*....|....*....|...
gi 71991121 636 VPISLVRDDGVVYSSGLTFSYKS 658
Cdd:cd01176  75 VPISLVRNDGIIYPTGLTFTYTP 97
 
Name Accession Description Interval E-value
BTD pfam09270
Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a ...
 409-534 1.01e-76

Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR).


Pssm-ID: 462734  Cd Length: 123  Bit Score: 241.08  E-value: 1.01e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121   409 EGNAFHASSTKWGAFTIHLFDDERGLQEtdNFAVRDGFVYYGSVVKLVDSVTGIALPRLRIRKVDKQQVILDAscsEEPV 488
Cdd:pfam09270   1 EGGAFHASSTQWGAFTIHLLDDNQGEQE--NFTVRDGFICYGSVVKLVCSVTGVALPPLIIRKVDKQQVILDA---DEPV 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 71991121   489 SQLHKCAFQMIDNELVYLCLSHDKIIQHQATAI--NEHRHQINDGAAW 534
Cdd:pfam09270  76 SQLHKCAFQMKDTERMYLCLSQEKIIQFQATPCpkDPNREVLNDGACW 123
LAG1-DNAbind pfam09271
LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical ...
 215-378 1.29e-64

LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding. This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins.


Pssm-ID: 462735  Cd Length: 148  Bit Score: 209.86  E-value: 1.29e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121   215 ISIFHAKVAQKSYGNEKRFFCPPPCIYLIGQGWKLKKdrvaQLYKTLKASAQKDAAIENDPIHEQQATELVAYIGIGSDT 294
Cdd:pfam09271   1 VIILHAKVAQKSYGTEKRFLCPPPCVYLLGPGWKTKS----TALSPDNPLTAPRVTISISGEDSAEESQCIAWIGMIGST 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121   295 SERQqldfstgkvrhpgDQRQDPNIYDYCAAKTLYISDSD-KRKYFDLNAQFFYGCGMEIGGFVSQRIKVISKPSKKKQS 373
Cdd:pfam09271  77 SDQE-------------TQQLDLVVWGRCAAKTLYISDSDeKRKHFELLVKLFAPNGQEIGSFESKPIKVISKPSKKRQS 143


                  ....*
gi 71991121   374 MKNTD 378
Cdd:pfam09271 144 LKNAD 148
IPT_RBP-Jkappa cd01176
IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was ...
 556-658 1.48e-54

IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known as the integrase family. Further studies indicated that RBP-J kappa functions as a repressor of transcription, via destabilization of the general transcription factor IID and recruitment of histone deacetylase complexes.


Pssm-ID: 238581  Cd Length: 97  Bit Score: 181.50  E-value: 1.48e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121 556 PISPCPVVGSLEVDGHGEASRVELHGRDFKPNLKVWFGATPVETTFRSEESLHCSIPPVSQVRNEQTHwmftnrTTGDVE 635
Cdd:cd01176   1 PVTPVPVVSSLELNGGGDVAMLELHGENFTPNLKVWFGDVEAETMYRCEESLLCVVPDISAFREEWRW------VRQPVQ 74

                        90       100
                ....*....|....*....|...
gi 71991121 636 VPISLVRDDGVVYSSGLTFSYKS 658
Cdd:cd01176  75 VPISLVRNDGIIYPTGLTFTYTP 97
TIG_SUH pfam20144
TIG domain; This entry represents a TIG-like domain found in the suppressor of hairless ...
 561-656 6.58e-35

TIG domain; This entry represents a TIG-like domain found in the suppressor of hairless protein.


Pssm-ID: 466305  Cd Length: 92  Bit Score: 127.33  E-value: 6.58e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121   561 PVVGSLEVDGHGEASRVELHGRDFKPNLKVWFGATPVETTFRSEESLHCSIPPVSQVRNEQTHWMFTNRttgdVEVPISL 640
Cdd:pfam20144   1 PVVSSLTVNGGGENAMLELHGENFTRDLKVWFGDIKAETEYRSRESLVCVVPDASELLSSWTSQKDRKK----KKVPLLL 76

                          90
                  ....*....|....*.
gi 71991121   641 VRDDGVVYSSGLTFSY 656
Cdd:pfam20144  77 VRGDGVIYKTGLTFTY 92
 
Name Accession Description Interval E-value
BTD pfam09270
Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a ...
 409-534 1.01e-76

Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR).


Pssm-ID: 462734  Cd Length: 123  Bit Score: 241.08  E-value: 1.01e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121   409 EGNAFHASSTKWGAFTIHLFDDERGLQEtdNFAVRDGFVYYGSVVKLVDSVTGIALPRLRIRKVDKQQVILDAscsEEPV 488
Cdd:pfam09270   1 EGGAFHASSTQWGAFTIHLLDDNQGEQE--NFTVRDGFICYGSVVKLVCSVTGVALPPLIIRKVDKQQVILDA---DEPV 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 71991121   489 SQLHKCAFQMIDNELVYLCLSHDKIIQHQATAI--NEHRHQINDGAAW 534
Cdd:pfam09270  76 SQLHKCAFQMKDTERMYLCLSQEKIIQFQATPCpkDPNREVLNDGACW 123
LAG1-DNAbind pfam09271
LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical ...
 215-378 1.29e-64

LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding. This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins.


Pssm-ID: 462735  Cd Length: 148  Bit Score: 209.86  E-value: 1.29e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121   215 ISIFHAKVAQKSYGNEKRFFCPPPCIYLIGQGWKLKKdrvaQLYKTLKASAQKDAAIENDPIHEQQATELVAYIGIGSDT 294
Cdd:pfam09271   1 VIILHAKVAQKSYGTEKRFLCPPPCVYLLGPGWKTKS----TALSPDNPLTAPRVTISISGEDSAEESQCIAWIGMIGST 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121   295 SERQqldfstgkvrhpgDQRQDPNIYDYCAAKTLYISDSD-KRKYFDLNAQFFYGCGMEIGGFVSQRIKVISKPSKKKQS 373
Cdd:pfam09271  77 SDQE-------------TQQLDLVVWGRCAAKTLYISDSDeKRKHFELLVKLFAPNGQEIGSFESKPIKVISKPSKKRQS 143


                  ....*
gi 71991121   374 MKNTD 378
Cdd:pfam09271 144 LKNAD 148
IPT_RBP-Jkappa cd01176
IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was ...
 556-658 1.48e-54

IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known as the integrase family. Further studies indicated that RBP-J kappa functions as a repressor of transcription, via destabilization of the general transcription factor IID and recruitment of histone deacetylase complexes.


Pssm-ID: 238581  Cd Length: 97  Bit Score: 181.50  E-value: 1.48e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121 556 PISPCPVVGSLEVDGHGEASRVELHGRDFKPNLKVWFGATPVETTFRSEESLHCSIPPVSQVRNEQTHwmftnrTTGDVE 635
Cdd:cd01176   1 PVTPVPVVSSLELNGGGDVAMLELHGENFTPNLKVWFGDVEAETMYRCEESLLCVVPDISAFREEWRW------VRQPVQ 74

                        90       100
                ....*....|....*....|...
gi 71991121 636 VPISLVRDDGVVYSSGLTFSYKS 658
Cdd:cd01176  75 VPISLVRNDGIIYPTGLTFTYTP 97
TIG_SUH pfam20144
TIG domain; This entry represents a TIG-like domain found in the suppressor of hairless ...
 561-656 6.58e-35

TIG domain; This entry represents a TIG-like domain found in the suppressor of hairless protein.


Pssm-ID: 466305  Cd Length: 92  Bit Score: 127.33  E-value: 6.58e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121   561 PVVGSLEVDGHGEASRVELHGRDFKPNLKVWFGATPVETTFRSEESLHCSIPPVSQVRNEQTHWMFTNRttgdVEVPISL 640
Cdd:pfam20144   1 PVVSSLTVNGGGENAMLELHGENFTRDLKVWFGDIKAETEYRSRESLVCVVPDASELLSSWTSQKDRKK----KKVPLLL 76

                          90
                  ....*....|....*.
gi 71991121   641 VRDDGVVYSSGLTFSY 656
Cdd:pfam20144  77 VRGDGVIYKTGLTFTY 92
IPT_TF cd00602
IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated ...
 559-657 8.18e-21

IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region.


Pssm-ID: 238336  Cd Length: 101  Bit Score: 87.72  E-value: 8.18e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121 559 PCPVVGSLEVDG-HGEASRVELHGRDfKPNLKVWFGAT-------PVETTFRSEE-SLHCSIPPVSQVRNEQThwmftnr 629
Cdd:cd00602   2 PICRVSSLSGSVnGGDEVFLLCDKVN-KPDIKVWFGEKgpgetvwEAEAMFRQEDvRQVAIVFKTPPYHNKWI------- 73

                        90       100
                ....*....|....*....|....*...
gi 71991121 630 tTGDVEVPISLVRDDGVVYSSGLTFSYK 657
Cdd:cd00602  74 -TRPVQVPIQLVRPDDRKRSEPLTFTYT 100
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 557-658 8.72e-07

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 47.46  E-value: 8.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991121 557 ISP--CPVVGSLEVDGHGEasrvelhGRDFKPNLKVWFGA-TPVETTFRSEESLHCSIPPVsqvrneqthwmftnRTTGD 633
Cdd:cd00102   6 ISPssGPVSGGTEVTITGS-------NFGSGSNLRVTFGGgVPCSVLSVSSTAIVCTTPPY--------------ANPGP 64

                        90       100
                ....*....|....*....|....*
gi 71991121 634 VEVPISLVRDDGVVYSSGLTFSYKS 658
Cdd:cd00102  65 GPVEVTVDRGNGGITSSPLTFTYVP 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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