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Conserved domains on  [gi|808356292|ref|NP_001023268|]
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Serpentine Receptor, class Z [Caenorhabditis elegans]

Protein Classification

class Z serpentine receptor( domain architecture ID 5111)

class Z serpentine receptor (Srz) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srz super family cl10995
Serpentine type 7TM GPCR chemoreceptor Srz; Chemoreception is mediated in Caenorhabditis ...
 43-281 1.19e-14

Serpentine type 7TM GPCR chemoreceptor Srz; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.


The actual alignment was detected with superfamily member pfam10325:

Pssm-ID: 431214  Cd Length: 264  Bit Score: 72.24  E-value: 1.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356292   43 YVQKLyNSKREKT---LPIVTHLYKTGQNSSYLVIYISISILSYLVgmvwnifdmdqdHNHSTLNLMAICNFLVIvAALL 119
Cdd:pfam10325  20 YVFKL-NRERDKKtllFPITNHFYKMVKISYFLFIFLIVILILIFF------------FSSKNSIIGFIFLLLIF-LILY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356292  120 FLTAFRGAFDFLVVLSSIQISLLYFFPAIEGTLTKIQNLVIRFILIIYFLCGFMGMTRIALTYGKDvlrglpDGTSLVKI 199
Cdd:pfam10325  86 ILYIITQVFHLLIFLLAIQRFLIYFFPSTEKYVLISQKYLHKYIWILYLVFVLKDLILFLLYVITF------SKSLGWET 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356292  200 RDVVYMETFVLNGIFLFSSIINFLGII-----------GEHPKLQKYMFCQSFLVFIEKTISSIYIT--------DDYWD 260
Cdd:pfam10325 160 IKYVYLIIFIILNILLFLSALLYIPIMisirklshlasAQLNKPQKYIFWQTITVLIFKSIYIPLFIfiflidflSEFLI 239

                         250       260
                  ....*....|....*....|.
gi 808356292  261 FTFLFIVDLFTLPLIIQLSYL 281
Cdd:pfam10325 240 FSIISITDILTTPLIIQLSYL 260
 
Name Accession Description Interval E-value
7TM_GPCR_Srz pfam10325
Serpentine type 7TM GPCR chemoreceptor Srz; Chemoreception is mediated in Caenorhabditis ...
 43-281 1.19e-14

Serpentine type 7TM GPCR chemoreceptor Srz; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.


Pssm-ID: 431214  Cd Length: 264  Bit Score: 72.24  E-value: 1.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356292   43 YVQKLyNSKREKT---LPIVTHLYKTGQNSSYLVIYISISILSYLVgmvwnifdmdqdHNHSTLNLMAICNFLVIvAALL 119
Cdd:pfam10325  20 YVFKL-NRERDKKtllFPITNHFYKMVKISYFLFIFLIVILILIFF------------FSSKNSIIGFIFLLLIF-LILY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356292  120 FLTAFRGAFDFLVVLSSIQISLLYFFPAIEGTLTKIQNLVIRFILIIYFLCGFMGMTRIALTYGKDvlrglpDGTSLVKI 199
Cdd:pfam10325  86 ILYIITQVFHLLIFLLAIQRFLIYFFPSTEKYVLISQKYLHKYIWILYLVFVLKDLILFLLYVITF------SKSLGWET 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356292  200 RDVVYMETFVLNGIFLFSSIINFLGII-----------GEHPKLQKYMFCQSFLVFIEKTISSIYIT--------DDYWD 260
Cdd:pfam10325 160 IKYVYLIIFIILNILLFLSALLYIPIMisirklshlasAQLNKPQKYIFWQTITVLIFKSIYIPLFIfiflidflSEFLI 239

                         250       260
                  ....*....|....*....|.
gi 808356292  261 FTFLFIVDLFTLPLIIQLSYL 281
Cdd:pfam10325 240 FSIISITDILTTPLIIQLSYL 260
 
Name Accession Description Interval E-value
7TM_GPCR_Srz pfam10325
Serpentine type 7TM GPCR chemoreceptor Srz; Chemoreception is mediated in Caenorhabditis ...
 43-281 1.19e-14

Serpentine type 7TM GPCR chemoreceptor Srz; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.


Pssm-ID: 431214  Cd Length: 264  Bit Score: 72.24  E-value: 1.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356292   43 YVQKLyNSKREKT---LPIVTHLYKTGQNSSYLVIYISISILSYLVgmvwnifdmdqdHNHSTLNLMAICNFLVIvAALL 119
Cdd:pfam10325  20 YVFKL-NRERDKKtllFPITNHFYKMVKISYFLFIFLIVILILIFF------------FSSKNSIIGFIFLLLIF-LILY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356292  120 FLTAFRGAFDFLVVLSSIQISLLYFFPAIEGTLTKIQNLVIRFILIIYFLCGFMGMTRIALTYGKDvlrglpDGTSLVKI 199
Cdd:pfam10325  86 ILYIITQVFHLLIFLLAIQRFLIYFFPSTEKYVLISQKYLHKYIWILYLVFVLKDLILFLLYVITF------SKSLGWET 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356292  200 RDVVYMETFVLNGIFLFSSIINFLGII-----------GEHPKLQKYMFCQSFLVFIEKTISSIYIT--------DDYWD 260
Cdd:pfam10325 160 IKYVYLIIFIILNILLFLSALLYIPIMisirklshlasAQLNKPQKYIFWQTITVLIFKSIYIPLFIfiflidflSEFLI 239

                         250       260
                  ....*....|....*....|.
gi 808356292  261 FTFLFIVDLFTLPLIIQLSYL 281
Cdd:pfam10325 240 FSIISITDILTTPLIIQLSYL 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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