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Conserved domains on  [gi|71994313|ref|NP_001022888|]
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putative voltage-gated potassium channel subunit kvs-4 [Caenorhabditis elegans]

Protein Classification

potassium voltage-gated channel protein( domain architecture ID 13034531)

potassium voltage-gated channel protein similar to Caenorhabditis elegans probable voltage-gated potassium channel subunit kvs-4 that mediates transmembrane potassium transport in excitable membranes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 229-477 6.55e-40

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 144.33  E-value: 6.55e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313   229 AQAFAVCSVVFVLISISGLVLGSLPELQVATKQrnnltgeeftemepmpILGYIEYVCIVWFTMEYGLKMLVSAERSKTF 308
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT----------------VLEILDYVFTGIFTLEMLLKIIAAGFKKRYF 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313   309 RQLLNIIDLLAILPFIIEMLLlifgisteqlrDLKGAFLVIRILRVLRVIRVLKLGRYSSGLQMFGKTLKASFRQLGMMA 388
Cdd:pfam00520  65 RSPWNILDFVVVLPSLISLVL-----------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLL 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313   389 MVVMTGVIFFSTLVYFLEK---------DEPASKFHSIPAACWWCIVTMTTVGYGDLTPVTVPGK-------LVATGAIA 452
Cdd:pfam00520 134 LLLLLFLFIFAIIGYQLFGgklktwenpDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIIL 213

                         250       260
                  ....*....|....*....|....*
gi 71994313   453 CGVLVLALPITIIVDNFMKVAETER 477
Cdd:pfam00520 214 GGFLLLNLFIAVIIDNFQELTERTE 238
BTB_POZ_Kv cd18317
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-172 6.91e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.


:

Pssm-ID: 349626  Cd Length: 82  Bit Score: 108.85  E-value: 6.91e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGGQRFMLRKDTIRRRGVGRLLDLINKPVAdsnadaFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCPVDI 164
Cdd:cd18317   1 VVLNVGGTRFELSRSTLLRFPDTRLGKLAKESHA------YDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVCPASF 74


                ....*...
gi 71994313 165 IEELEYWR 172
Cdd:cd18317  75 KEELEFWG 82
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 229-477 6.55e-40

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 144.33  E-value: 6.55e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313   229 AQAFAVCSVVFVLISISGLVLGSLPELQVATKQrnnltgeeftemepmpILGYIEYVCIVWFTMEYGLKMLVSAERSKTF 308
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT----------------VLEILDYVFTGIFTLEMLLKIIAAGFKKRYF 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313   309 RQLLNIIDLLAILPFIIEMLLlifgisteqlrDLKGAFLVIRILRVLRVIRVLKLGRYSSGLQMFGKTLKASFRQLGMMA 388
Cdd:pfam00520  65 RSPWNILDFVVVLPSLISLVL-----------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLL 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313   389 MVVMTGVIFFSTLVYFLEK---------DEPASKFHSIPAACWWCIVTMTTVGYGDLTPVTVPGK-------LVATGAIA 452
Cdd:pfam00520 134 LLLLLFLFIFAIIGYQLFGgklktwenpDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIIL 213

                         250       260
                  ....*....|....*....|....*
gi 71994313   453 CGVLVLALPITIIVDNFMKVAETER 477
Cdd:pfam00520 214 GGFLLLNLFIAVIIDNFQELTERTE 238
BTB_POZ_Kv cd18317
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-172 6.91e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.


Pssm-ID: 349626  Cd Length: 82  Bit Score: 108.85  E-value: 6.91e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGGQRFMLRKDTIRRRGVGRLLDLINKPVAdsnadaFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCPVDI 164
Cdd:cd18317   1 VVLNVGGTRFELSRSTLLRFPDTRLGKLAKESHA------YDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVCPASF 74


                ....*...
gi 71994313 165 IEELEYWR 172
Cdd:cd18317  75 KEELEFWG 82
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
 85-182 1.49e-18

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 80.33  E-value: 1.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313    85 VKLNVGGQRFMLRKDTIRRRGVGRLLDLInkpvaDSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGV-IHQPSNLCPVD 163
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLL-----ELECDDYDDDTNEYFFDRSPKHFETILNFYRTGGkLHRPEEVCLDE 75

                          90
                  ....*....|....*....
gi 71994313   164 IIEELEYWRiIPDQYLASC 182
Cdd:pfam02214  76 FLEEAEFYG-LDELALELC 93
PRK10537 PRK10537
voltage-gated potassium channel protein;
388-466 1.94e-08

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 56.18  E-value: 1.94e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71994313  388 AMVVMTGVIFFSTLVYFLEKDEPASKFHSIPAACWWCIVTMTTVGYGDLTPVTVPGKLVATGAIACGVLVLALPITIIV 466
Cdd:PRK10537 140 AVISITSLLFYSTFGALYLGDGFSPPIESLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSISAIF 218
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 85-184 7.88e-03

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 35.74  E-value: 7.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313     85 VKLNVGGQRFMLRKDTIRRRGvGRLLDLINKPVADSNadaffsSTSEFYFERPPSLFHIVYQF-YLNGVIHQPSNLcpVD 163
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHS-PYFKALFSSDFKESD------KSEIYLDDVSPEDFRALLNFlYTGKLDLPEENV--EE 72

                           90       100
                   ....*....|....*....|.
gi 71994313    164 IIEELEYWRIipdQYLASCCC 184
Cdd:smart00225  73 LLELADYLQI---PGLVELCE 90
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 229-477 6.55e-40

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 144.33  E-value: 6.55e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313   229 AQAFAVCSVVFVLISISGLVLGSLPELQVATKQrnnltgeeftemepmpILGYIEYVCIVWFTMEYGLKMLVSAERSKTF 308
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT----------------VLEILDYVFTGIFTLEMLLKIIAAGFKKRYF 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313   309 RQLLNIIDLLAILPFIIEMLLlifgisteqlrDLKGAFLVIRILRVLRVIRVLKLGRYSSGLQMFGKTLKASFRQLGMMA 388
Cdd:pfam00520  65 RSPWNILDFVVVLPSLISLVL-----------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLL 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313   389 MVVMTGVIFFSTLVYFLEK---------DEPASKFHSIPAACWWCIVTMTTVGYGDLTPVTVPGK-------LVATGAIA 452
Cdd:pfam00520 134 LLLLLFLFIFAIIGYQLFGgklktwenpDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIIL 213

                         250       260
                  ....*....|....*....|....*
gi 71994313   453 CGVLVLALPITIIVDNFMKVAETER 477
Cdd:pfam00520 214 GGFLLLNLFIAVIIDNFQELTERTE 238
BTB_POZ_Kv cd18317
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-172 6.91e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.


Pssm-ID: 349626  Cd Length: 82  Bit Score: 108.85  E-value: 6.91e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGGQRFMLRKDTIRRRGVGRLLDLINKPVAdsnadaFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCPVDI 164
Cdd:cd18317   1 VVLNVGGTRFELSRSTLLRFPDTRLGKLAKESHA------YDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVCPASF 74


                ....*...
gi 71994313 165 IEELEYWR 172
Cdd:cd18317  75 KEELEFWG 82
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
 85-182 1.49e-18

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 80.33  E-value: 1.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313    85 VKLNVGGQRFMLRKDTIRRRGVGRLLDLInkpvaDSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGV-IHQPSNLCPVD 163
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLL-----ELECDDYDDDTNEYFFDRSPKHFETILNFYRTGGkLHRPEEVCLDE 75

                          90
                  ....*....|....*....
gi 71994313   164 IIEELEYWRiIPDQYLASC 182
Cdd:pfam02214  76 FLEEAEFYG-LDELALELC 93
BTB_POZ_Kv2_KCNB cd18378
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-183 2.57e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349687 [Multi-domain]  Cd Length: 109  Bit Score: 71.66  E-value: 2.57e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGGQRFMLR---KDTIRRRGVGRLLDLINKPVADSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCP 161
Cdd:cd18378   4 VLLNVGGVRHEVLwrtLDRLPRTRLGRLRECNTHESLLELCDDYDLEDNEYFFDRHPGAFTSILNFYRTGKLHMPEEMCV 83

                        90       100
                ....*....|....*....|..
gi 71994313 162 VDIIEELEYWRiIPDQYLASCC 183
Cdd:cd18378  84 LSFSQELEYWG-IDEIYLESCC 104
BTB_POZ_Kv5_KCNF1 cd18381
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-183 1.93e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNF/Kv5 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv5, also known as subfamily F, only contains KCNF1 (also known as Kv5.1 or kH1), which functions as a regulatory alpha-subunit of voltage-gated potassium channel that when coassembled with Kv2.1 can modulate gating in a physiologically relevant manner. It forms hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349690  Cd Length: 116  Bit Score: 69.40  E-value: 1.93e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGGQRFMLRKDTIRRRGVGRLLDLINKpvADSNADAFFS-------STSEFYFERPPSLFHIVYQFYLNGVIHQPS 157
Cdd:cd18381   3 IVVNVGGVRQVLYGDVLNRYPETRLAELLNC--LSGGYDAIFSlcddydpGKREFYFDRDPDAFKCIIEVYYYGEIHMKK 80

                        90       100
                ....*....|....*....|....*.
gi 71994313 158 NLCPVDIIEELEYWRIIPDqYLASCC 183
Cdd:cd18381  81 GICPICFKNEMDFWRVDLD-FLDECC 105
BTB_POZ_Kv3_KCNC cd18379
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-183 9.66e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349688 [Multi-domain]  Cd Length: 109  Bit Score: 67.42  E-value: 9.66e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGGQRFMLRKDTIRRRGVGRLLDLINKPVADSNADAffsSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCPVDI 164
Cdd:cd18379   1 IVINVGGVRHETYKSTLRNLPDTRLAWLTETEASAFDYDP---VTGEFFFDRHPGVFAQILNYYRTGKLHCPADVCGPLF 77

                        90
                ....*....|....*....
gi 71994313 165 IEELEYWRIIPDQyLASCC 183
Cdd:cd18379  78 EEELAFWGIDETQ-IEPCC 95
BTB_POZ_KCNS2 cd18427
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-183 5.01e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 2 (KCNS2); KCNS2, also called delayed-rectifier K(+) channel alpha subunit 2 or voltage-gated potassium channel subunit Kv9.2, is a modulatory alpha subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349734  Cd Length: 107  Bit Score: 65.25  E-value: 5.01e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGGQRFMLRKDTIRR---RGVGRLLDLINKPVADSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCP 161
Cdd:cd18427   2 ISINVGGFKKRLRSHTLLRfpeTRLGRLLSCRSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCV 81

                        90       100
                ....*....|....*....|..
gi 71994313 162 VDIIEELEYWRiIPDQYLASCC 183
Cdd:cd18427  82 FSFSQEIEYWG-INEFFIDSCC 102
BTB_POZ_Kv4_KCND cd18380
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-184 3.09e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349689 [Multi-domain]  Cd Length: 102  Bit Score: 62.77  E-value: 3.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGGQRFMLRKDTIRRrgvgrlldLINKPVADSNADAFFSS-TSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCPVD 163
Cdd:cd18380   2 IVINVSGRRFETWKNTLEK--------YPDTLLGSTEKEFFYDDdTKEYFFDRDPEIFRHILNFYRTGKLHYPRHECISA 73

                        90       100
                ....*....|....*....|.
gi 71994313 164 IIEELEYWRIIPDqYLASCCC 184
Cdd:cd18380  74 YDDELAFFGILPE-IIGDCCY 93
BTB_POZ_KCNS1 cd18426
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-183 6.37e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 1 (KCNS1); KCNS1, also called delayed-rectifier K(+) channel alpha subunit 1 or voltage-gated potassium channel subunit Kv9.1, is a modulatory alpha subunit of voltage-gated potassium channel that mediates neuropathic pain following nerve injury. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349733 [Multi-domain]  Cd Length: 106  Bit Score: 62.22  E-value: 6.37e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGGQRFMLRKDTIRR---RGVGRLLDLINKPVADSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCP 161
Cdd:cd18426   1 ININVGGLKRRLSSSTLSKfpdTRLGRLLSCDSEESILQICDDYDVSAKEFYFDRNPGLFPYVLHFYQTGKLHIMEELCV 80

                        90       100
                ....*....|....*....|..
gi 71994313 162 VDIIEELEYWRiIPDQYLASCC 183
Cdd:cd18426  81 FSFSQEIEYWG-INEFFLDSCC 101
BTB_POZ_KCNS3 cd18428
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 83-183 1.40e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3); KCNS3, also called delayed-rectifier K(+) channel alpha subunit 3 or voltage-gated potassium channel subunit Kv9.3, is an alpha subunit of voltage-gated potassium channel linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349735  Cd Length: 108  Bit Score: 61.01  E-value: 1.40e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  83 QFVKLNVGGQRFMLRKDTIRR---RGVGRLLDLINKPVADSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNL 159
Cdd:cd18428   1 ELINLNVGGFKQSVDQSTLLRfphTRLGKLLNCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEEL 80

                        90       100
                ....*....|....*....|....
gi 71994313 160 CPVDIIEELEYWRiIPDQYLASCC 183
Cdd:cd18428  81 CVFSFCQEIEYWG-INELFIDSCC 103
BTB_POZ_Kv9_KCNS cd18384
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-186 1.59e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.


Pssm-ID: 349692  Cd Length: 106  Bit Score: 61.00  E-value: 1.59e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGGQRFMLRKDTIRR---RGVGRLLDLINKPVADSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCP 161
Cdd:cd18384   1 IRINVGGFRRRLSASALLRfpgTRLGRLLACHSEEAILELCDDYDVAAREFYFDRNPGFFLYVLHFYRTGKLHVMDELCV 80

                        90       100
                ....*....|....*....|....*
gi 71994313 162 VDIIEELEYWRiIPDQYLASCCCAQ 186
Cdd:cd18384  81 FSFSQEIEYWG-INEFFLDSCCSYR 104
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 390-471 1.93e-11

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 59.97  E-value: 1.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313   390 VVMTGVIFFSTLVYFLEkdepASKFHSIPAACWWCIVTMTTVGYGDLTPVTVPGKLVATGAIACGVLVLALPITIIVDNF 469
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLE----EGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76


                  ..
gi 71994313   470 MK 471
Cdd:pfam07885  77 TE 78
BTB_POZ_KCNV2 cd18425
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-183 2.28e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 2 (KCNV2); KCNV2, also called voltage-gated potassium channel subunit Kv8.2, is a modulatory voltage-gated potassium channel alpha subunit that modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNV2 is essential for visual function and cone survival. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349732  Cd Length: 108  Bit Score: 60.55  E-value: 2.28e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  87 LNVGGQRFMLRKDTIRR---RGVGRLLDLINKPVADSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCPVD 163
Cdd:cd18425   3 INVGGTSYQISYRVAASypkTRIGRLATYTDRSRKLDLCDDYNVQNDEYFFDRDPAVFHHIYNFYRTGVLWVKDELCPRN 82

                        90       100
                ....*....|....*....|..
gi 71994313 164 IIEELEYW--RIipdQYLASCC 183
Cdd:cd18425  83 FLEEINYWgvRI---KNTPRCC 101
BTB_POZ_KCND2 cd18418
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 84-183 4.56e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349725 [Multi-domain]  Cd Length: 103  Bit Score: 59.59  E-value: 4.56e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  84 FVKLNVGGQRFMLRKDTIRRRGvgrlldliNKPVADSNADAFFS-STSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCPV 162
Cdd:cd18418   1 LIVLNVSGTRFQTWRNTLERYP--------DTLLGSSERDFFYHeETQEYFFDRDPDIFRHILNFYRTGKLHYPRHECIS 72

                        90       100
                ....*....|....*....|.
gi 71994313 163 DIIEELEYWRIIPdQYLASCC 183
Cdd:cd18418  73 AYDEELAFFGIIP-EIIGDCC 92
BTB_Shaw-like cd18416
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 82-183 5.81e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349723 [Multi-domain]  Cd Length: 112  Bit Score: 59.59  E-value: 5.81e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  82 EQFVKLNVGGQRFMLRKDTIRRRGVGRLLDLINkpvADSNADAFFSstsEFYFERPPSLFHIVYQFYLNGVIHQPSNLCP 161
Cdd:cd18416   1 ENRVVLNVGGIRHETYKATLKKIPATRLSRLTE---ALANYDPVLN---EYFFDRHPGVFAQILNYYRTGKLHYPTDVCG 74

                        90       100
                ....*....|....*....|..
gi 71994313 162 VDIIEELEYWRIIPDQyLASCC 183
Cdd:cd18416  75 PLFEEELEFWGLDANQ-VEPCC 95
BTB_KCNC1_3 cd18414
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 81-184 3.12e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349721 [Multi-domain]  Cd Length: 117  Bit Score: 57.66  E-value: 3.12e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  81 SEQFVkLNVGGQRFMLRKDTIRRRGvGRLLDLINKPVADSNADaFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLC 160
Cdd:cd18414   2 SDRIV-INVGGTRHETYRSTLRTLP-GTRLAWLAEPDAHSNFD-YDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVC 78

                        90       100
                ....*....|....*....|....
gi 71994313 161 PVDIIEELEYWRIipDQYLASCCC 184
Cdd:cd18414  79 GPLYEEELAFWGI--DETDVEPCC 100
BTB_POZ_KCND1 cd18417
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 81-183 4.74e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349724 [Multi-domain]  Cd Length: 138  Bit Score: 57.65  E-value: 4.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  81 SEQFVKLNVGGQRFMLRKDTIRRRGvgrlldliNKPVADSNADAFFSS-TSEFYFERPPSLFHIVYQFYLNGVIHQPSNL 159
Cdd:cd18417  33 NDEILVVNVSGRRFQTWKNTLDRYP--------DTLLGSSEKEFFYNEdTQEYFFDRDPEMFRHILNFYRTGRLHYPRHE 104

                        90       100
                ....*....|....*....|....
gi 71994313 160 CPVDIIEELEYWRIIPDqYLASCC 183
Cdd:cd18417 105 CIQAFDEELSFYGIIPE-IIGDCC 127
BTB_POZ_KCND3 cd18419
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 82-183 6.18e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349726 [Multi-domain]  Cd Length: 138  Bit Score: 57.29  E-value: 6.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  82 EQFVKLNVGGQRFMLRKDTIRRrgvgrlldLINKPVADSNADAFFSS-TSEFYFERPPSLFHIVYQFYLNGVIHQPSNLC 160
Cdd:cd18419  34 DELIVLNVSGRRFQTWRTTLER--------YPDTLLGSTEKEFFFNEdTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYEC 105

                        90       100
                ....*....|....*....|...
gi 71994313 161 PVDIIEELEYWRIIPdQYLASCC 183
Cdd:cd18419 106 ISAYDEELAFYGILP-EIIGDCC 127
BTB_POZ_KCNB1 cd18411
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-186 6.49e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 1 (KCNB1); KCNB1, also called delayed rectifier potassium channel 1 (DRK1) or voltage-gated potassium channel subunit Kv2.1, mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB1 is involved in the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349718 [Multi-domain]  Cd Length: 117  Bit Score: 56.55  E-value: 6.49e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGG--QRFMLRK-DTIRRRGVGRLLDLINKPVADSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCP 161
Cdd:cd18411  12 VKLNVGGlaHEVLWRTlDRLPRTRLGKLRDCNTHESLMEICDDYNLEENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCA 91

                        90       100
                ....*....|....*....|....*
gi 71994313 162 VDIIEELEYWRiIPDQYLASCCCAQ 186
Cdd:cd18411  92 LSFSQELDYWG-IDEIYLESCCQAR 115
BTB_POZ_KCNV1 cd18424
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-184 9.17e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349731  Cd Length: 109  Bit Score: 55.98  E-value: 9.17e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  87 LNVGGQRFMLRKDTIR---RRGVGRLLDLINKPVADSNADAFFSsTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCPVD 163
Cdd:cd18424   3 INVGGSRFVLSQQVLSshpETRLGKLAVSVRDSVLELCDDANFV-DNEYFFDRSSQAFKYIMNYYKTGHLHVMEELCAIS 81

                        90       100
                ....*....|....*....|.
gi 71994313 164 IIEELEYWRIipDQYLASCCC 184
Cdd:cd18424  82 FLQEIEYWGI--DELSIDSCC 100
BTB_POZ_KCNB2 cd18412
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-186 1.48e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349719 [Multi-domain]  Cd Length: 127  Bit Score: 56.17  E-value: 1.48e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGG--QRFMLRK-DTIRRRGVGRLLDLINKPVADSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCP 161
Cdd:cd18412  19 VKINVGGlnHEVLWRTlDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCA 98

                        90       100
                ....*....|....*....|....*
gi 71994313 162 VDIIEELEYWRiIPDQYLASCCCAQ 186
Cdd:cd18412  99 LSFGQELDYWG-IDEIYLESCCQAR 122
BTB_POZ_Shal-like cd18420
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 82-183 5.33e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349727 [Multi-domain]  Cd Length: 139  Bit Score: 54.85  E-value: 5.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  82 EQFVKLNVGGQRFMLRKDTIRRrgvgrlldlINKPVADSNADAFF--SSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNL 159
Cdd:cd18420  35 DEKLIINVSGRRFETWRNTLEK---------YPDTLLGSNEREFFydEETKEYFFDRDPDIFRHILNYYRTGKLHYPKHE 105

                        90       100
                ....*....|....*....|....
gi 71994313 160 CPVDIIEELEYWRIIPDqYLASCC 183
Cdd:cd18420 106 CLTAYDEELAFFGIMPD-IIGDCC 128
BTB_POZ_Shab-like cd18413
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-183 8.78e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shab and similar proteins; Shab is a slow delayed rectifier voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shab is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349720 [Multi-domain]  Cd Length: 109  Bit Score: 53.35  E-value: 8.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGGQRFMLRKDTIRR---RGVGRLLDLINKPVADSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCP 161
Cdd:cd18413   4 VVINVGGVKHEVLWRTLDRmphTRLGKLRDSNTHEAIVELCDDYSLADNEYFFDRHPRSFASILNFYRTGKLHLVEEMCV 83

                        90       100
                ....*....|....*....|..
gi 71994313 162 VDIIEELEYWRiIPDQYLASCC 183
Cdd:cd18413  84 LAFSDDLEYWG-VDELYLESCC 104
PRK10537 PRK10537
voltage-gated potassium channel protein;
388-466 1.94e-08

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 56.18  E-value: 1.94e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71994313  388 AMVVMTGVIFFSTLVYFLEKDEPASKFHSIPAACWWCIVTMTTVGYGDLTPVTVPGKLVATGAIACGVLVLALPITIIV 466
Cdd:PRK10537 140 AVISITSLLFYSTFGALYLGDGFSPPIESLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSISAIF 218
BTB_POZ_KCTD-like cd18316
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-171 3.92e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349625  Cd Length: 83  Bit Score: 50.63  E-value: 3.92e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGGQRFMLRKDTIRRRGVGRLLDLINkpvadSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNlcPVD- 163
Cdd:cd18316   1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFS-----GRWPLPRDEDGSIFIDRDPELFRHILNFLRTGKLPLPSD--FVEl 73

                        90
                ....*....|
gi 71994313 164 --IIEELEYW 171
Cdd:cd18316  74 eeLLAEAEFY 83
BTB_POZ_KCNG4 cd18423
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 82-183 8.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349730 [Multi-domain]  Cd Length: 112  Bit Score: 47.51  E-value: 8.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  82 EQFVKLNVGGQRFMLRKDTIRRRGVGRLLDLINKPVADSN---ADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSN 158
Cdd:cd18423   1 KREIIINVGGIKYLMPWSTLDEFPLTRLGKLKFCSSYEEIvqiCDDYDEDTNEFFFDRNPCAFRMIVSFLAAGKLRLLRE 80

                        90       100
                ....*....|....*....|....*
gi 71994313 159 LCPVDIIEELEYWRiIPDQYLASCC 183
Cdd:cd18423  81 MCALSFQEELTYWG-IEEANLERCC 104
BTB_KCNC2_4 cd18415
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-184 1.19e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349722 [Multi-domain]  Cd Length: 124  Bit Score: 47.46  E-value: 1.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGGQRFMLRKDTIRRRGVGRLLDLINKP------VADSNADAFFSST---SEFYFERPPSLFHIVYQFYLNGVIHQ 155
Cdd:cd18415   4 IILNVGGTRHETYRSTLKTLPGTRLALLASSDpqgdclTQCSQVGGSDGSPgggNEFFFDRHPGVFAYVLNYYRTGKLHC 83

                        90       100
                ....*....|....*....|....*....
gi 71994313 156 PSNLCPVDIIEELEYWRIipDQYLASCCC 184
Cdd:cd18415  84 PADVCGPLFEEELAFWGI--DETDVEPCC 110
BTB_POZ_Kv6_KCNG cd18382
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-183 2.49e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.


Pssm-ID: 349691 [Multi-domain]  Cd Length: 109  Bit Score: 43.19  E-value: 2.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGGQRFMLRKDTIRR---RGVGRLLDLINKPVADSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCP 161
Cdd:cd18382   1 VIINVGGARYSLPWSTLDRfplTRLSRLKACRSEDDILRVCDDYDVERNEFFFDRSPEAFGVILLFLRAGKLRLLREMCA 80

                        90       100
                ....*....|....*....|..
gi 71994313 162 VDIIEELEYWRiIPDQYLASCC 183
Cdd:cd18382  81 LSFQEELAYWG-IEEAHLERCC 101
BTB_POZ_KCNG1_2 cd18421
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 84-183 5.35e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2; KCNG1, also called voltage-gated potassium channel subunit Kv6.1 or kH2, functions as a regulatory alpha-subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit or voltage-gated potassium channel subunit Kv6.2, is a new gamma-subunit of voltage-gated potassium channels that can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG1 and KCNG2 are regulatory alpha subunits and do not form homomultimers. They form heteromultimers (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349728 [Multi-domain]  Cd Length: 114  Bit Score: 42.43  E-value: 5.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  84 FVKLNVGGQRFMLRKDTIRRRGVGRLLDLINKPVAD---SNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLC 160
Cdd:cd18421   5 HVIINVGGIKYRIPWTTLEEFPLTRLGQLKSCNNFDeimDICDDYDVTCNEFFFDRNPCAFRTILTFLRAGKLRLLREMC 84

                        90       100
                ....*....|....*....|...
gi 71994313 161 PVDIIEELEYWRiIPDQYLASCC 183
Cdd:cd18421  85 ALSFQEELLYWG-IEEENLEWCC 106
BTB_POZ_KCTD5 cd18390
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 81-173 2.45e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.


Pssm-ID: 349698 [Multi-domain]  Cd Length: 112  Bit Score: 40.74  E-value: 2.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  81 SEQFVKLNVGGQRFMLRKDTIRRRGVGRLLDLINkpvADSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLC 160
Cdd:cd18390   3 VSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQ---ADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLA 79

                        90
                ....*....|...
gi 71994313 161 PVDIIEELEYWRI 173
Cdd:cd18390  80 EEGVLEEAEFYNI 92
BTB_POZ_KCTD17 cd18391
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 83-175 5.04e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.


Pssm-ID: 349699  Cd Length: 101  Bit Score: 39.59  E-value: 5.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  83 QFVKLNVGGQRFMLRKDTIRRRGVGRLLDLINKPVADSNADaffsSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCPV 162
Cdd:cd18391   1 KWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRD----ETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEE 76

                        90
                ....*....|...
gi 71994313 163 DIIEELEYWRIIP 175
Cdd:cd18391  77 GVLEEAEFYNIGP 89
BTB_POZ_KCNG3 cd18422
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-183 1.64e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 3 (KCNG3); KCNG3, also called voltage-gated potassium channel subunit Kv6.3 or voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349729  Cd Length: 111  Bit Score: 38.30  E-value: 1.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  85 VKLNVGGQRFMLRKDTIRR---RGVGRLLDLINKPVADSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCP 161
Cdd:cd18422   1 VTLNVGGTRYSFSREVIKDfplRRVSRLHGCLSEQDVLEVCDDYDRERNEYFFDRHSEAFGFIMLYVKYGKLRFVPQMCE 80

                        90       100
                ....*....|....*....|..
gi 71994313 162 VDIIEELEYWRiIPDQYLASCC 183
Cdd:cd18422  81 LSFYNEMIYWG-LERSHLEYCC 101
BTB_POZ_KCTD2 cd18389
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 83-174 6.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.


Pssm-ID: 349697 [Multi-domain]  Cd Length: 105  Bit Score: 36.50  E-value: 6.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313  83 QFVKLNVGGQRFMLRKDTIRRRGVGRLLDLINK-PVADSNADaffsSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCP 161
Cdd:cd18389   1 KWVRLNVGGTYFVSTKQTLCRDPKSFLYRLCQEdPDLDSDKD----ETGAYLIDRDPTYFGPILNYLRHGKLIINKELAE 76

                        90
                ....*....|...
gi 71994313 162 VDIIEELEYWRII 174
Cdd:cd18389  77 EGVLEEAEFYNIA 89
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 85-184 7.88e-03

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 35.74  E-value: 7.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994313     85 VKLNVGGQRFMLRKDTIRRRGvGRLLDLINKPVADSNadaffsSTSEFYFERPPSLFHIVYQF-YLNGVIHQPSNLcpVD 163
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHS-PYFKALFSSDFKESD------KSEIYLDDVSPEDFRALLNFlYTGKLDLPEENV--EE 72

                           90       100
                   ....*....|....*....|.
gi 71994313    164 IIEELEYWRIipdQYLASCCC 184
Cdd:smart00225  73 LLELADYLQI---PGLVELCE 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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