|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
130-540 |
1.17e-81 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 260.09 E-value: 1.17e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 130 IGGLIMAAAVEKCDLHERVALSVLRCVGSEPKWIMLGFMTVTALLSSFISNTATTAMMVPIGQSVVQQLissfqhhptng 209
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 210 erGRLGCKKMATGLVLSICFAANIGGTGTATGTPSNLVMLGQLSALFpkvDGSLNYVTWIFFAYPLMLLCLFVAWmTLVS 289
Cdd:COG0471 70 --GSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEAT---GIPISFFEWMLVGLPVALVGLLLLW-LVLY 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 290 FFLRDAPEKDEAVTEMLKTRYNELPRMTYAEKSVFVCFCILLSLWVFRNPGVVPgfgvffkkgaytDATSAMIVAFLLFV 369
Cdd:COG0471 144 RLLPPEIKEVPGSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIP------------IAVVALLGAVLLLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 370 LpserpdlatyikkedlkkrGCLmDWKTMQETFPWSVVLLLGGGFALAAGVKESGLSLLIGNSLSS-IEHLPLWILQLLT 448
Cdd:COG0471 212 T-------------------GVL-TWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLL 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 449 MLIAMVITNICSNTVTASIFVPIVATLAQRAGHHPFTLMLPTTLASSFAFIFPVGTPPNAIVFGSGMVKVSDMAFVGGII 528
Cdd:COG0471 272 ALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPL 351
|
410
....*....|..
gi 71988385 529 SLELLVLTVLYM 540
Cdd:COG0471 352 NLIGLVVLLLLG 363
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
83-543 |
4.95e-64 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 214.37 E-value: 4.95e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 83 IIAVYWMSEVMPLAVTAMLPVVLFPLVGVLDANTTAKEYMNDTNFLFIGGLIMAAAVEKCDLHERVALSVLRCVGSEPKW 162
Cdd:cd01115 6 FAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 163 IMLGFMTVTALLSSFISNTATTAMMVPIGQSVVQQLISSfqhhptngergrlgckkmATGLVLSICFAANIGGTGTATGT 242
Cdd:cd01115 86 LLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDIS------------------PSRLLMPLAFAASIGGMLTLIGT 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 243 PSNLVMLGQLSALFPkvdGSLNYVTWIFFAYPLMLLCLFVAWMTLVsfflrdapekdeavtemlktrynelprmtyaeks 322
Cdd:cd01115 148 PPNLVASGYLESLGG---QGFSFFEFTPIGLPLLIIGLLYLWFIFR---------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 323 vFVCFCILLSLWVFrnpgvvpgfgVFFKKGAYTDATSAMIVAFLLFVlpserpdlatyikkedlkkrGCLMDWKTMQETF 402
Cdd:cd01115 191 -LAVLIITIVLLAA----------LAAITGLLPVSVAIAIGAIVLVF--------------------GGVLLTKEDYKSI 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 403 PWSVVLLLGGGFALAAGVKESGLSLLIGNSLSSI-EHLPLWILQLLTMLIAMVITNICSNTVTASIFVPIVATLAQRAGH 481
Cdd:cd01115 240 DWGIIFLFAGGIPLGKALESSGAAALIAEALISLlGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGL 319
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71988385 482 HPFTLMLPTTLASSFAFIFPVGTPPNAIVFGSGMVKVSDMAFVGGIISLELLVLTVLYMNSI 543
Cdd:cd01115 320 PPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLI 381
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
74-542 |
7.43e-56 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 195.28 E-value: 7.43e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 74 EWKCAYCVCIIAVYWMSEVMPLAVTAMLPVVLFPLVGVLDANT----TAKEYMNDTNFLFIGGLIMAAAVEKCDLHERVA 149
Cdd:pfam00939 30 AWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLAKalswALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 150 LSVLRCVGSEPkwIMLGFMTVTALLSSFISNTATTAMMVPIGQSVVQQLISSFQHHPTNGERGRLGckkmaTGLVLSICF 229
Cdd:pfam00939 110 LVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPAFGSDPEKGSERRIG-----AYLMWTVYQ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 230 AANIGGTGTATGTPSNLVMLGQLSALFPKVdgsLNYVTWIFFAYPLMLLCLFVAWMTLVSFFLRDAPEKDEAVTeMLKTR 309
Cdd:pfam00939 183 STSITSAMFLTAMAPNLLLLGLMNSILGVT---ITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKSVPDAKA-IAKTE 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 310 YNELPRMTYAEKSVFVCFCILLSLWVFRN-PGVvpgfgvffkkgayTDATSAMIVAFLLFVLPserpdlatyikkedlkk 388
Cdd:pfam00939 259 LKELGPMTFREKALLGLFVLLLLLWIFGGsLNI-------------DATTVAIIGLALMLLLR----------------- 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 389 rgcLMDWK-TMQETFPWSVVLLLGGGFALAAGVKESGLSLLIGNSLSSIEHLPLWILQLLTMLIAMVITN--ICSNTVTA 465
Cdd:pfam00939 309 ---ILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMAFIIILSLFYLSHylFASATAHT 385
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71988385 466 SIFVPIVATLAQRA-GHHPFTLMLPTTLASSFA-FIFPVGTPPNAIVFGSGMVKVSDMAFVGGIISLELLVLTVLYMNS 542
Cdd:pfam00939 386 AAMLPIFAAVAQAIpGAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNW 464
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
84-539 |
3.91e-47 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 170.60 E-value: 3.91e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 84 IAVYWMSEVMPLAVTAMLPV-VLFPLVGVLDANTTAKE---YMNDTNFLFIGGLIMAAAVEKCDLHERVALSVLRCVGSE 159
Cdd:TIGR00785 20 AIVGWILEPLPLPVTALLAIpIIAVLLGVLSAFKFKNAlsgFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGKMGGT 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 160 PKWI-MLGFMTVTALLSSFISNTA-TTAMMVPIGQSVVQQLISSfqhhPTNGERgrlgckKMATGLVLSICFAANIGGTG 237
Cdd:TIGR00785 100 TLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLLGSK----PEKSPR------KIGKYLMLGIAYSASIGSSG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 238 TATGTPSNLVMLGQLSALFPKVdgsLNYVTWIFFAYPLMLLCLFVAWMTLVSFFLRDAPEKDEAVTEMlKTRYNELPRMT 317
Cdd:TIGR00785 170 FLTGSAPNALAAGILSKILGIQ---ISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELKLKDEVDLWA-KEELEEMGPMS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 318 YAEKSVFVCFCILLSLWVFRNPGVVPgfgvffkkgAYTDATSAMIVAFLLFVLPserpdlatyikkedlkkrgclmdWKT 397
Cdd:TIGR00785 246 FREKALLGIFLLALLLWIFGGSLGIN---------ASVVALLAVVLMLFLGIVT-----------------------WKD 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 398 MQETFP-WSVVLLLGGGFALAAGVKESGLSLLIGNSLSSI--EHLPLWILQLLTMLIAMVITNICSNTVTASIFVPIVAT 474
Cdd:TIGR00785 294 IQKNKVaWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGIldGLSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFS 373
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71988385 475 LAQRAGHHPFTLMLPTTLASSFA-FIFPVGTPPNAIVFGSGMVKVSDMAFVGGIISLELLVLTVLY 539
Cdd:TIGR00785 374 VASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLV 439
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
130-540 |
1.17e-81 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 260.09 E-value: 1.17e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 130 IGGLIMAAAVEKCDLHERVALSVLRCVGSEPKWIMLGFMTVTALLSSFISNTATTAMMVPIGQSVVQQLissfqhhptng 209
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 210 erGRLGCKKMATGLVLSICFAANIGGTGTATGTPSNLVMLGQLSALFpkvDGSLNYVTWIFFAYPLMLLCLFVAWmTLVS 289
Cdd:COG0471 70 --GSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEAT---GIPISFFEWMLVGLPVALVGLLLLW-LVLY 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 290 FFLRDAPEKDEAVTEMLKTRYNELPRMTYAEKSVFVCFCILLSLWVFRNPGVVPgfgvffkkgaytDATSAMIVAFLLFV 369
Cdd:COG0471 144 RLLPPEIKEVPGSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIP------------IAVVALLGAVLLLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 370 LpserpdlatyikkedlkkrGCLmDWKTMQETFPWSVVLLLGGGFALAAGVKESGLSLLIGNSLSS-IEHLPLWILQLLT 448
Cdd:COG0471 212 T-------------------GVL-TWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLL 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 449 MLIAMVITNICSNTVTASIFVPIVATLAQRAGHHPFTLMLPTTLASSFAFIFPVGTPPNAIVFGSGMVKVSDMAFVGGII 528
Cdd:COG0471 272 ALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPL 351
|
410
....*....|..
gi 71988385 529 SLELLVLTVLYM 540
Cdd:COG0471 352 NLIGLVVLLLLG 363
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
83-543 |
4.95e-64 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 214.37 E-value: 4.95e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 83 IIAVYWMSEVMPLAVTAMLPVVLFPLVGVLDANTTAKEYMNDTNFLFIGGLIMAAAVEKCDLHERVALSVLRCVGSEPKW 162
Cdd:cd01115 6 FAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 163 IMLGFMTVTALLSSFISNTATTAMMVPIGQSVVQQLISSfqhhptngergrlgckkmATGLVLSICFAANIGGTGTATGT 242
Cdd:cd01115 86 LLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDIS------------------PSRLLMPLAFAASIGGMLTLIGT 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 243 PSNLVMLGQLSALFPkvdGSLNYVTWIFFAYPLMLLCLFVAWMTLVsfflrdapekdeavtemlktrynelprmtyaeks 322
Cdd:cd01115 148 PPNLVASGYLESLGG---QGFSFFEFTPIGLPLLIIGLLYLWFIFR---------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 323 vFVCFCILLSLWVFrnpgvvpgfgVFFKKGAYTDATSAMIVAFLLFVlpserpdlatyikkedlkkrGCLMDWKTMQETF 402
Cdd:cd01115 191 -LAVLIITIVLLAA----------LAAITGLLPVSVAIAIGAIVLVF--------------------GGVLLTKEDYKSI 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 403 PWSVVLLLGGGFALAAGVKESGLSLLIGNSLSSI-EHLPLWILQLLTMLIAMVITNICSNTVTASIFVPIVATLAQRAGH 481
Cdd:cd01115 240 DWGIIFLFAGGIPLGKALESSGAAALIAEALISLlGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGL 319
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71988385 482 HPFTLMLPTTLASSFAFIFPVGTPPNAIVFGSGMVKVSDMAFVGGIISLELLVLTVLYMNSI 543
Cdd:cd01115 320 PPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLI 381
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
74-542 |
7.43e-56 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 195.28 E-value: 7.43e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 74 EWKCAYCVCIIAVYWMSEVMPLAVTAMLPVVLFPLVGVLDANT----TAKEYMNDTNFLFIGGLIMAAAVEKCDLHERVA 149
Cdd:pfam00939 30 AWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLAKalswALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 150 LSVLRCVGSEPkwIMLGFMTVTALLSSFISNTATTAMMVPIGQSVVQQLISSFQHHPTNGERGRLGckkmaTGLVLSICF 229
Cdd:pfam00939 110 LVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPAFGSDPEKGSERRIG-----AYLMWTVYQ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 230 AANIGGTGTATGTPSNLVMLGQLSALFPKVdgsLNYVTWIFFAYPLMLLCLFVAWMTLVSFFLRDAPEKDEAVTeMLKTR 309
Cdd:pfam00939 183 STSITSAMFLTAMAPNLLLLGLMNSILGVT---ITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKSVPDAKA-IAKTE 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 310 YNELPRMTYAEKSVFVCFCILLSLWVFRN-PGVvpgfgvffkkgayTDATSAMIVAFLLFVLPserpdlatyikkedlkk 388
Cdd:pfam00939 259 LKELGPMTFREKALLGLFVLLLLLWIFGGsLNI-------------DATTVAIIGLALMLLLR----------------- 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 389 rgcLMDWK-TMQETFPWSVVLLLGGGFALAAGVKESGLSLLIGNSLSSIEHLPLWILQLLTMLIAMVITN--ICSNTVTA 465
Cdd:pfam00939 309 ---ILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMAFIIILSLFYLSHylFASATAHT 385
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71988385 466 SIFVPIVATLAQRA-GHHPFTLMLPTTLASSFA-FIFPVGTPPNAIVFGSGMVKVSDMAFVGGIISLELLVLTVLYMNS 542
Cdd:pfam00939 386 AAMLPIFAAVAQAIpGAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNW 464
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
84-539 |
3.91e-47 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 170.60 E-value: 3.91e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 84 IAVYWMSEVMPLAVTAMLPV-VLFPLVGVLDANTTAKE---YMNDTNFLFIGGLIMAAAVEKCDLHERVALSVLRCVGSE 159
Cdd:TIGR00785 20 AIVGWILEPLPLPVTALLAIpIIAVLLGVLSAFKFKNAlsgFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGKMGGT 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 160 PKWI-MLGFMTVTALLSSFISNTA-TTAMMVPIGQSVVQQLISSfqhhPTNGERgrlgckKMATGLVLSICFAANIGGTG 237
Cdd:TIGR00785 100 TLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLLGSK----PEKSPR------KIGKYLMLGIAYSASIGSSG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 238 TATGTPSNLVMLGQLSALFPKVdgsLNYVTWIFFAYPLMLLCLFVAWMTLVSFFLRDAPEKDEAVTEMlKTRYNELPRMT 317
Cdd:TIGR00785 170 FLTGSAPNALAAGILSKILGIQ---ISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELKLKDEVDLWA-KEELEEMGPMS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 318 YAEKSVFVCFCILLSLWVFRNPGVVPgfgvffkkgAYTDATSAMIVAFLLFVLPserpdlatyikkedlkkrgclmdWKT 397
Cdd:TIGR00785 246 FREKALLGIFLLALLLWIFGGSLGIN---------ASVVALLAVVLMLFLGIVT-----------------------WKD 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 398 MQETFP-WSVVLLLGGGFALAAGVKESGLSLLIGNSLSSI--EHLPLWILQLLTMLIAMVITNICSNTVTASIFVPIVAT 474
Cdd:TIGR00785 294 IQKNKVaWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGIldGLSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFS 373
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71988385 475 LAQRAGHHPFTLMLPTTLASSFA-FIFPVGTPPNAIVFGSGMVKVSDMAFVGGIISLELLVLTVLY 539
Cdd:TIGR00785 374 VASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLV 439
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
85-540 |
4.12e-38 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 144.70 E-value: 4.12e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 85 AVYWMSEVMPLAVTAMLPVVLFPLVGVLDANTTAKEYMNDTNFLFIGGLIMAAAVEKCDLHERVALSVLRcVGSEPKWIM 164
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLAR-ASKGSRRLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 165 LGFMTVTALLSSFISNTATTAMMVPIGQSVVQQLissfqhhptngergrlgCKKMATGLVLSICFAANIGGTGTATGTPS 244
Cdd:cd00625 80 LLLMLLTAALSAFFSNDATAVLLTPIVLALLRKL-----------------GLSPPVPLLLALAFAANIGGAATPIGNPP 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 245 NLvMLGQLSalfpkvdgSLNYVTWIFFAYPLMLLCLFVAWMTLVSFFLRDAPEKDEAVTEMLKTRYNELPRMTyaEKSVF 324
Cdd:cd00625 143 NL-IIASLS--------GLGFLDFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEDKLTVLAEPLPARPLLK--KFLLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 325 VCFCILLSLWVfrnpgvvpgFGVFFKKGAYTDATSAMIVAFLLFVLpserpdlatyikkedlkkrgclmDWKTMQETFPW 404
Cdd:cd00625 212 ALLLLLLFVLL---------FFFLIPLGLIALLGALLLLLLLVRGL-----------------------DPEEVLKSVDW 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 405 SVVLLLGGGFALAAGVKESGLSLLIGNSLSSIEHLPLWILQLLTMLIAMVITNICSNTVTASIFVPIVATL-----AQRA 479
Cdd:cd00625 260 GTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLappepAWLA 339
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71988385 480 GHHPFTLMLPTTLASSFAFIFPVGTPPNAIVfgsgMVKVSDMAFVGGIISLELLVLTVLYM 540
Cdd:cd00625 340 LALGSTLGGNLTLIGSLANLIPLGAAENAGV----GISFGEFLKVGLPLTLLSLVVSLLYL 396
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
85-488 |
2.95e-32 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 127.04 E-value: 2.95e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 85 AVYWMSEVMPLAVTAMLPVVLFPLVGVLDANTTAKEYMNDTNFLFIGGLIMAAAVEKCDLHERVALSVLRCVGSEPKWIM 164
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 165 LGFMTVTALLSSFISNTATTAMMVPIGQSVVQQLISSfqhhptngergrlgckkmATGLVLSICFAANIGGTGTATGTPS 244
Cdd:pfam03600 81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLP------------------PSPLLIALAFAANIGGTATPIGDPP 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 245 NLVMLGQLSALFPKvdgslnyvtWIFFAYPLMLLCLFVAWMTLVSFFLRdapeKDEAVTEMLKTRYNELPRMTYAEKSVF 324
Cdd:pfam03600 143 NIIIASALGLSFGD---------FGFFMFPPVGVALLLVGLLPLLLIFR----KLLPVRKEEEAELEELRKRAIKDKLLL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 325 VCFCILLSLWVFRNPGVVPgfgvffkkgaytdatSAMIVAFLLFVlpserpdlatyikkedlkkrGCLMDWKTMQETFPW 404
Cdd:pfam03600 210 AISALVLALVILGFLLLSV---------------LALAGALLLLL--------------------TGVLDPEEALKAVDW 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 405 SVVLLLGGGFALAAGVKESGLSLLIGNSLSSIehLPLWILQLLTMLIAMVITNICSNTVTASIFVPIVATLAQRAGHHPF 484
Cdd:pfam03600 255 STLLFFAGLFILVGALEKTGLADALADALGGL--SGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDP 332
|
....
gi 71988385 485 TLML 488
Cdd:pfam03600 333 DPLA 336
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
81-512 |
3.38e-15 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 77.86 E-value: 3.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 81 VCIIAVYWMSEVMPLAVTAMLPVVLFPLVGVLDANTTAKEYMNDTNFLFIGGLIMAAAVEKCDLHERVALSVLRCVGSEP 160
Cdd:COG1055 11 LTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 161 KWIMLGFMTVTALLSSFISNTATTAMMVPIGQSVVQqlissfqhhptngergRLGCKKMAtgLVLSICFAANIGGTGTAT 240
Cdd:COG1055 91 RRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIAR----------------RLGLNPVP--FLIAIVFAANIGGAATPI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 241 GTPSNLvMLGQlsalfpkvDGSLNYVTWIFFAYPLMLLCLFVAWMTLVSFFLRDAPEKDEAvtEMLKTRYNELPRMTYae 320
Cdd:COG1055 153 GNPTNI-MIAS--------AGGLSFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPDL--EDDPKEAIKDRRLLR-- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 321 KSVFVCFCILlslwvfrnpgVVPGFGVFFKKGAytdATSAMIVAFLLFVLpsERPDLATYIKKedlkkrgclmdwktmqe 400
Cdd:COG1055 220 ISLLVLALLL----------VGFVLHSFLGLPP---ALIALLGAAVLLLL--ARVDVREVLKK----------------- 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 401 tFPWSVVLLLGGGFALAAGVKESGLSLLIGNSLSSIEHLPLWILQLLTMLIAMVITNICSNTVTASIFVPIVATLAQRAG 480
Cdd:COG1055 268 -VDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGN 346
|
410 420 430
....*....|....*....|....*....|....
gi 71988385 481 HHPF--TLMLPTTLASSfafIFPVGTPPNAIVFG 512
Cdd:COG1055 347 PEPLwlALALGATLGGN---LTPIGSAANVIVLG 377
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
70-198 |
7.03e-11 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 64.02 E-value: 7.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 70 WEGPEWKCAYCVCIIAVYWMSE---VMPLAVTAMLPVVLFPLVGVLDANTTAKEYMNDTNFLFIGGLIMAAAVEKCDLHE 146
Cdd:COG0471 170 LSRREKIALAIFALTVLLWITGslhGIPIAVVALLGAVLLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAA 249
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 71988385 147 RVALSVLRCVGSEPKWIML-GFMTVTALLSSFISNTATTAMMVPIGQSVVQQL 198
Cdd:COG0471 250 WLADALLPLLGGLSPLLLLlLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
392-538 |
7.92e-11 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 63.87 E-value: 7.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 392 LMDWKTMQETFPWSVVLLLGGGFALAAGVKESGLSLLIGNSLSSIEHLPLWILQLLTMLIAMVITNICSNTVTASIFVPI 471
Cdd:pfam03600 27 VLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIMIPI 106
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71988385 472 VATLAQRAGHHPFTLMLPTTLASSFAFIF-PVGTPPNAIVFGSGMVKVSDMAFVGGIISLELLVLTVL 538
Cdd:pfam03600 107 VLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGL 174
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
89-497 |
4.79e-07 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 52.25 E-value: 4.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 89 MSEVMPLAVTAMLPVVLFPLVGVLDANTTAKEYMN----DTNFLFIGGLIMAAAVEKCDLHERVALSVLRCVGSEPKWIM 164
Cdd:cd01116 9 IFEKVHRTVAALAGALWLVILGLATLSPDLETIVSwvdwETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 165 LGFMTVTALLSSFISNTATTAMMVPIGQSVVQQLissfqhhptngergrlgcKKMATGLVLSICFAANIGGTGTATGTPS 244
Cdd:cd01116 89 LLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVL------------------GLNPVPVLISEVIAANIGGAATLIGDPP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 245 NLvMLGQlsalfpkvDGSLNYVTWIFFAYPLMLLCLFVAWMtLVSFFLRDAPEKDEAVTEMLKtryNELPRMTYAEKSVF 324
Cdd:cd01116 151 NI-MIGS--------AAGLTFNDFLLHMLPSVVLALVVTFI-LLYFLYRNILKAREEDVLALA---ELEPKYPIKDKVLL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 325 VCFCILLSLWVFRN-----PGVVPGFgvffkkgaytdatsAMIVAFLLFVLPSERPDLATYIKKEDlkkrgclmdwktmq 399
Cdd:cd01116 218 LKSLTILTLVIIGFvlhspLGVSLGW--------------IALLGALLLLLLADKLDFEDVLSRVE-------------- 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 400 etfpWSVVLLLGGGFALAAGVKESGL-----SLLIGNSLSSIEHLPLWILQLLTMLIAmVITNIcsnTVTAsIFVPIVAT 474
Cdd:cd01116 270 ----WDTLLFFAGLFVLVGGLEELGIiewiaELLVGVILGRIAVAVILILWISALLSA-FIDNI---PVTA-TMIPIVKD 340
|
410 420
....*....|....*....|...
gi 71988385 475 LAQRAGHHPFTLMLPTTLASSFA 497
Cdd:cd01116 341 LASQLGIPLLPLWWALALGACLG 363
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
81-292 |
3.16e-04 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 43.19 E-value: 3.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 81 VCIIAVYWMSEV--MPLAVTAMLPVVLFPLVGVLDANTTAKEYMNDTNFLFIGGLIMAAAVEKCDLHERVALSVLRCVGS 158
Cdd:COG1055 226 ALLLVGFVLHSFlgLPPALIALLGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGG 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988385 159 EPKWIMLGFMTVTALLSSFISNTATTAMMVPigqsVVQQLISSFQHHPtngergrlgckkMATGLVLSICFAANIGGTGT 238
Cdd:COG1055 306 NLLLAALLILWLSAILSAVVDNVPLVAALLP----LIPDLGATGNPEP------------LWLALALGATLGGNLTPIGS 369
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 71988385 239 AtgtpSNLVMLGQLSalfpKVDGSLNYVTWIFFAYPLMLLCLFVAWMTLVSFFL 292
Cdd:COG1055 370 A----ANVIVLGIAE----KKGIKISFGEFLKVGLPLTLLTLLIALLYLLLLYF 415
|
|
| |
