NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|71983486|ref|NP_001021337|]
View 

Protein let-653 [Caenorhabditis elegans]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ZP super family cl42957
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 447-568 2.11e-18

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


The actual alignment was detected with superfamily member smart00241:

Pssm-ID: 214579  Cd Length: 252  Bit Score: 85.13  E-value: 2.11e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983486    447 DIFHNGQPVEAVVVGTKISLSFRPHY-PIPPEYVDVRGCQVEPIDPKyeWEHEPLFIIRDGCPADGVGL-VCPPTHS-EF 523
Cdd:smart00241 133 DSFGSPYQSADYVLGDPVYHEWECDGaDDPPLGLLVDNCYATPGPDP--SSGPKYFIIDNGCPVDGYLDsTIPYNSNpLH 210

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 71983486    524 GAKVSVEAFRYQTTGQVQYSCLVRICPFAPCPknTCDDVeGCDSS 568
Cdd:smart00241 211 RARFSVKVFKFADRSLVYFHCQIRLCDKDDGS--SCDGP-ACSSR 252
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 124-208 1.06e-13

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


:

Pssm-ID: 238532  Cd Length: 80  Bit Score: 66.72  E-value: 1.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983486 124 SGEYAFTyLSDRYMDQKSVIKWTTKANLEECLSDCLDEKSFECRSISFNRTDGGCHMSKDSQISRPEAIRLNNNpnyrID 203
Cdd:cd01099   1 LNDFKFV-LVLNKILVSEVKTEITVASLEECLRKCLEETEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDSN----VD 75


                ....*
gi 71983486 204 YYENN 208
Cdd:cd01099  76 YYENK 80
 
Name Accession Description Interval E-value
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 447-568 2.11e-18

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 85.13  E-value: 2.11e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983486    447 DIFHNGQPVEAVVVGTKISLSFRPHY-PIPPEYVDVRGCQVEPIDPKyeWEHEPLFIIRDGCPADGVGL-VCPPTHS-EF 523
Cdd:smart00241 133 DSFGSPYQSADYVLGDPVYHEWECDGaDDPPLGLLVDNCYATPGPDP--SSGPKYFIIDNGCPVDGYLDsTIPYNSNpLH 210

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 71983486    524 GAKVSVEAFRYQTTGQVQYSCLVRICPFAPCPknTCDDVeGCDSS 568
Cdd:smart00241 211 RARFSVKVFKFADRSLVYFHCQIRLCDKDDGS--SCDGP-ACSSR 252
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 124-208 1.06e-13

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 66.72  E-value: 1.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983486 124 SGEYAFTyLSDRYMDQKSVIKWTTKANLEECLSDCLDEKSFECRSISFNRTDGGCHMSKDSQISRPEAIRLNNNpnyrID 203
Cdd:cd01099   1 LNDFKFV-LVLNKILVSEVKTEITVASLEECLRKCLEETEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDSN----VD 75


                ....*
gi 71983486 204 YYENN 208
Cdd:cd01099  76 YYENK 80
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 128-209 1.05e-10

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 57.95  E-value: 1.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983486   128 AFTYLSDRYMDQKSVIKWTTkANLEECLSDCLDEKSfeCRSISFNRTDGGCHMSKDSQISRPEAIRLNNNpnyrIDYYEN 207
Cdd:pfam00024   2 DFERVPGSSLSGVDVSTVTV-SSAEECAQRCTNEPR--CRSFTYNPKSKKCHLKSSSSGSLPRLKRSDNK----VDYYEK 74


                  ..
gi 71983486   208 NC 209
Cdd:pfam00024  75 SC 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 124-208 3.51e-09

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 53.74  E-value: 3.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983486    124 SGEYAFTYLSDRYMDqKSVIKWTTKANLEECLSDCLDEKsFECRSISFNRTDGGCHMSKDSQISRPEAIrlnnnPNYRID 203
Cdd:smart00473   1 KSDDCFVRLPNTKLP-GFSRIVISVASLEECASKCLNSN-CSCRSFTYNNGTKGCLLWSESSLGDARLF-----PSGGVD 73


                   ....*
gi 71983486    204 YYENN 208
Cdd:smart00473  74 LYEKI 78
 
Name Accession Description Interval E-value
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 447-568 2.11e-18

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 85.13  E-value: 2.11e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983486    447 DIFHNGQPVEAVVVGTKISLSFRPHY-PIPPEYVDVRGCQVEPIDPKyeWEHEPLFIIRDGCPADGVGL-VCPPTHS-EF 523
Cdd:smart00241 133 DSFGSPYQSADYVLGDPVYHEWECDGaDDPPLGLLVDNCYATPGPDP--SSGPKYFIIDNGCPVDGYLDsTIPYNSNpLH 210

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 71983486    524 GAKVSVEAFRYQTTGQVQYSCLVRICPFAPCPknTCDDVeGCDSS 568
Cdd:smart00241 211 RARFSVKVFKFADRSLVYFHCQIRLCDKDDGS--SCDGP-ACSSR 252
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 124-208 1.06e-13

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 66.72  E-value: 1.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983486 124 SGEYAFTyLSDRYMDQKSVIKWTTKANLEECLSDCLDEKSFECRSISFNRTDGGCHMSKDSQISRPEAIRLNNNpnyrID 203
Cdd:cd01099   1 LNDFKFV-LVLNKILVSEVKTEITVASLEECLRKCLEETEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDSN----VD 75


                ....*
gi 71983486 204 YYENN 208
Cdd:cd01099  76 YYENK 80
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 128-209 1.05e-10

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 57.95  E-value: 1.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983486   128 AFTYLSDRYMDQKSVIKWTTkANLEECLSDCLDEKSfeCRSISFNRTDGGCHMSKDSQISRPEAIRLNNNpnyrIDYYEN 207
Cdd:pfam00024   2 DFERVPGSSLSGVDVSTVTV-SSAEECAQRCTNEPR--CRSFTYNPKSKKCHLKSSSSGSLPRLKRSDNK----VDYYEK 74


                  ..
gi 71983486   208 NC 209
Cdd:pfam00024  75 SC 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 124-208 3.51e-09

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 53.74  E-value: 3.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983486    124 SGEYAFTYLSDRYMDqKSVIKWTTKANLEECLSDCLDEKsFECRSISFNRTDGGCHMSKDSQISRPEAIrlnnnPNYRID 203
Cdd:smart00473   1 KSDDCFVRLPNTKLP-GFSRIVISVASLEECASKCLNSN-CSCRSFTYNNGTKGCLLWSESSLGDARLF-----PSGGVD 73


                   ....*
gi 71983486    204 YYENN 208
Cdd:smart00473  74 LYEKI 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH