|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
463-720 |
5.09e-145 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 440.48 E-value: 5.09e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCAFESLD-RLDTEGSGGILAHCMGLGKTLQVITFLHTVLMHEKIgEKCKRVLVVVPKNVIINWFKE 541
Cdd:cd18068 1 LKPHQVDGVQFMWDCCCESLKkTKKSPGSGCILAHCMGLGKTLQVVTFLHTVLLCEKL-ENFSRVLVVCPLNTVLNWLNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 542 FQKWLVDNDEElDTIDVNELDSYKTIEDRRraLKAWHSSKTPSVMIIGYDLFRILTVEDDPKKKkpknrnrrlEKAKEDF 621
Cdd:cd18068 80 FEKWQEGLKDE-EKIEVNELATYKRPQERS--YKLQRWQEEGGVMIIGYDMYRILAQERNVKSR---------EKLKEIF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 622 RKYLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNII 701
Cdd:cd18068 148 NKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPI 227
|
250
....*....|....*....
gi 71980419 702 NRGRTKDASPLEVSFMKRR 720
Cdd:cd18068 228 QNGQCADSTLVDVRVMKKR 246
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
463-720 |
1.96e-86 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 281.10 E-value: 1.96e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCAFESlDRLDTEGSGGILAHCMGLGKTLQVITFLHTVLMHEKIGekcKRVLVVVPKNVIINWFKEF 542
Cdd:cd18007 1 LKPHQVEGVRFLWSNLVGT-DVGSDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPRR---SRPLVLCPASTLYNWEDEF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 543 QKWLVDndEELDTIDVNELDSYKTIEDRRRALKAWHSSKtpSVMIIGYDLFRILTVEDDPKkkkpknrnrrlEKAKEDFR 622
Cdd:cd18007 77 KKWLPP--DLRPLLVLVSLSASKRADARLRKINKWHKEG--GVLLIGYELFRNLASNATTD-----------PRLKQEFI 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 623 KYLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNIIN 702
Cdd:cd18007 142 AALLDPGPDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIE 221
|
250
....*....|....*...
gi 71980419 703 RGRTKDASPLEVSFMKRR 720
Cdd:cd18007 222 AGQCVDSTEEDVRLMLKR 239
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
390-1124 |
2.64e-71 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 253.22 E-value: 2.64e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 390 DAERAEKERRKRLEKKQKEFNGIVLEEGEDLTEMLTGTSSQRKLKSVVLDPDSSTVDEESKKPVEVHNSLVRILKPHQAH 469
Cdd:COG0553 169 LLALEALLLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDAFRLRRLREALESLPAGLKATLRPYQLE 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 470 GIQFMYdcafesldRLDTEGSGGILAHCMGLGKTLQVITFLHtvlmHEKIGEKCKRVLVVVPKNVIINWFKEFQKWLvdn 549
Cdd:COG0553 249 GAAWLL--------FLRRLGLGGLLADDMGLGKTIQALALLL----ELKERGLARPVLIVAPTSLVGNWQRELAKFA--- 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 550 deelDTIDVNELDSyktIEDRRRALKAWHSSKtpsVMIIGYDLFRiltveddpkkkkpknrnrrlekakeDFRKYLQNPG 629
Cdd:COG0553 314 ----PGLRVLVLDG---TRERAKGANPFEDAD---LVITSYGLLR-------------------------RDIELLAAVD 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 630 PDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNIINRGRTKDA 709
Cdd:COG0553 359 WDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKGDEEAL 438
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 710 SPLEV---SFMKRRchvlydhlkkcvDRKDyrVLTEaIPPKQEYVINVRQTERQCALYNAFLNDivgdsglskrllpdyh 786
Cdd:COG0553 439 ERLRRllrPFLLRR------------TKED--VLKD-LPEKTEETLYVELTPEQRALYEAVLEY---------------- 487
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 787 mfsriwthpyqlvlheqrmerervMREdaeeeadfiddgdgsesesegsfksgsesdsgksvvlssddegsskkkkngnk 866
Cdd:COG0553 488 ------------------------LRR----------------------------------------------------- 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 867 pEIKKTAPQKKRkflnsddedeedgedtaMAILQDGIRQsKRLAgeeadlrdtDTPpeytgwfarlGLVKEEDRDDFALS 946
Cdd:COG0553 491 -ELEGAEGIRRR-----------------GLILAALTRL-RQIC---------SHP----------ALLLEEGAELSGRS 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 947 NKLILLVEIIKKCEEIGDKLLVFSQSlesltliKRMLEYMAgtgqwfadghEALNAEGEEtwswlegedYMTIDGSVQSG 1026
Cdd:COG0553 533 AKLEALLELLEELLAEGEKVLVFSQF-------TDTLDLLE----------ERLEERGIE---------YAYLHGGTSAE 586
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 1027 KRDAVQTSFNDPLNlrARLMLISTRAGSLGTNMVAANRVIIFDACWNPSHDTQSLFRVYRFGQTKPVYIYRFIAQGTMEE 1106
Cdd:COG0553 587 ERDELVDRFQEGPE--APVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEE 664
|
730
....*....|....*...
gi 71980419 1107 RIYKRQVTKESTSMRVVD 1124
Cdd:COG0553 665 KILELLEEKRALAESVLG 682
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
463-720 |
8.97e-68 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 227.78 E-value: 8.97e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCAFESLDRLDT-EGSGGILAHCMGLGKTLQVITFLHTVLMHEKIgekcKRVLVVVPKNVIINWFKE 541
Cdd:cd18069 1 LKPHQIGGIRFLYDNIIESLERYKGsSGFGCILAHSMGLGKTLQVISFLDVLLRHTGA----KTVLAIVPVNTLQNWLSE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 542 FQKWL----VDNDEELDTIDVNEL-DSYKTIEDRRRALKAWhsSKTPSVMIIGYDLFRIltveddpkkkkpknrnrrlek 616
Cdd:cd18069 77 FNKWLpppeALPNVRPRPFKVFILnDEHKTTAARAKVIEDW--VKDGGVLLMGYEMFRL--------------------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 617 akedfrkylqNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANR 696
Cdd:cd18069 134 ----------RPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNM 203
|
250 260
....*....|....*....|....
gi 71980419 697 FVNIINRGRTKDASPLEVSFMKRR 720
Cdd:cd18069 204 FERPILNGQCVDSTPQDVKLMRYR 227
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
466-796 |
1.81e-63 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 217.94 E-value: 1.81e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 466 HQAHGIQFMYDCAFESldrldteGSGGILAHCMGLGKTLQVITFLHTVL-MHEKIGEKckrVLVVVPKNVIINWFKEFQK 544
Cdd:pfam00176 1 YQIEGVNWMLSLENNL-------GRGGILADEMGLGKTLQTISLLLYLKhVDKNWGGP---TLIVVPLSLLHNWMNEFER 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 545 WLvdndeELDTIDVNELDSykTIEDRRRALKAWHSSKTPSVMIIGYDlfriltveddpkkkkpknrnrRLEKAKEDFRKY 624
Cdd:pfam00176 71 WV-----SPPALRVVVLHG--NKRPQERWKNDPNFLADFDVVITTYE---------------------TLRKHKELLKKV 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 625 lqnpGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNIINRG 704
Cdd:pfam00176 123 ----HWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 705 RTKDasplevsfmkrRCHVLYDHLKKCVDRKDYRVLTEAIPPKQEYVINVRQTERQCALYNAFL--------NDIVGDSG 776
Cdd:pfam00176 199 GGKK-----------GVSRLHKLLKPFLLRRTKKDVEKSLPPKVEYILFCRLSKLQRKLYQTFLlkkdlnaiKTGEGGRE 267
|
330 340
....*....|....*....|
gi 71980419 777 LSKRLLPDYHMFSRIWTHPY 796
Cdd:pfam00176 268 IKASLLNILMRLRKICNHPG 287
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
463-735 |
1.21e-59 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 205.21 E-value: 1.21e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCAfesLDRLDTEGSGGILAHCMGLGKTLQVITFLHTVLMHEKIGEK-CKRVLVVVPKNVIINWFKE 541
Cdd:cd18004 1 LRPHQREGVQFLYDCL---TGRRGYGGGGAILADEMGLGKTLQAIALVWTLLKQGPYGKPtAKKALIVCPSSLVGNWKAE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 542 FQKWLVDNDEELDTIDVNELDSYKTIEDRRralkawhSSKTPSVMIIGYDLFRILTveddpkkkkpknrnrrlekakedf 621
Cdd:cd18004 78 FDKWLGLRRIKVVTADGNAKDVKASLDFFS-------SASTYPVLIISYETLRRHA------------------------ 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 622 RKYLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNII 701
Cdd:cd18004 127 EKLSKKISIDLLICDEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPI 206
|
250 260 270
....*....|....*....|....*....|....
gi 71980419 702 NRGRTKDASPLEVSFMKRRCHVLYDHLKKCVDRK 735
Cdd:cd18004 207 LRSRDPDASEEDKELGAERSQELSELTSRFILRR 240
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
463-684 |
4.05e-51 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 178.14 E-value: 4.05e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCAFEsldrldteGSGGILAHCMGLGKTLQVITFLHTVLMHekiGEKCKRVLVVVPKNVIINWFKEF 542
Cdd:cd17919 1 LRPYQLEGLNFLLELYEN--------GPGGILADEMGLGKTLQAIAFLAYLLKE---GKERGPVLVVCPLSVLENWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 543 QKWLvdndeelDTIDVNELDSYKTIEDRRRALKAWHSSKtpsVMIIGYDLFRILTveddpkkkkpknrnrrlekakedfr 622
Cdd:cd17919 70 EKWT-------PDLRVVVYHGSQRERAQIRAKEKLDKFD---VVLTTYETLRRDK------------------------- 114
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71980419 623 KYLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKP 684
Cdd:cd17919 115 ASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPLQNNLEELWALLDFLDP 176
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
463-735 |
4.75e-44 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 160.33 E-value: 4.75e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCAfesLDRLDTEGSGGILAHCMGLGKTLQVITFLHTVLmheKIGEKCKR----VLVVVPKNVIINW 538
Cdd:cd18067 1 LRPHQREGVKFLYRCV---TGRRIRGSHGCIMADEMGLGKTLQCITLMWTLL---RQSPQCKPeidkAIVVSPSSLVKNW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 539 FKEFQKWLVDNDEELdTIDvneldsYKTIEDRRRALKAW---HSSKTPS-VMIIGYDLFRILTVEddpkkkkpknrnrrl 614
Cdd:cd18067 75 ANELGKWLGGRLQPL-AID------GGSKKEIDRKLVQWasqQGRRVSTpVLIISYETFRLHVEV--------------- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 615 ekakedfrkyLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFA 694
Cdd:cd18067 133 ----------LQKGEVGLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFK 202
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 71980419 695 NRFVNIINRGRTKDASPLEVSFMKRRCHVLYDHLKKCVDRK 735
Cdd:cd18067 203 KNFELPILKGRDADASEKERQLGEEKLQELISIVNRCIIRR 243
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
939-1099 |
1.36e-42 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 151.86 E-value: 1.36e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 939 DRDDFALSNKLILLVEIIKKCEEIGDKLLVFSQSLESLTLIKRMLEYmagtgqwfadghealnaegeetwswlEGEDYMT 1018
Cdd:cd18793 3 PKIEEVVSGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRE--------------------------RGIKYLR 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 1019 IDGSVQSGKRDAVQTSFNDPLNlrARLMLISTRAGSLGTNMVAANRVIIFDACWNPSHDTQSLFRVYRFGQTKPVYIYRF 1098
Cdd:cd18793 57 LDGSTSSKERQKLVDRFNEDPD--IRVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRL 134
|
.
gi 71980419 1099 I 1099
Cdd:cd18793 135 I 135
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
463-730 |
2.28e-42 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 155.22 E-value: 2.28e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYdcafesldRLDTEGSGGILAHCMGLGKTLQVITFLHTVLMHEKIgekcKRVLVVVPKNVIINWFKEF 542
Cdd:cd18001 1 LYPHQREGVAWLW--------SLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLI----KSVLVVMPTSLIPHWVKEF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 543 QKWlvdndeeldTIDVNELDSYKT-IEDRRRALKAWHSSKtpSVMIIGYDLFRiltveddpkkkkpkNRNRRLEKAKEDF 621
Cdd:cd18001 69 AKW---------TPGLRVKVFHGTsKKERERNLERIQRGG--GVLLTTYGMVL--------------SNTEQLSADDHDE 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 622 RKYlqnpgpDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPG-LLGTKTEFANRFVNI 700
Cdd:cd18001 124 FKW------DYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFACNGsLLGTRKTFKMEFENP 197
|
250 260 270
....*....|....*....|....*....|
gi 71980419 701 INRGRTKDASPLEVSFMKRRCHVLYDHLKK 730
Cdd:cd18001 198 ITRGRDKDATQGEKALGSEVAENLRQIIKP 227
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
463-735 |
3.45e-40 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 149.45 E-value: 3.45e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCAfesldrldTEGSGGILAHCMGLGKTLQVITFLHTVL------------MHEKIGEKC-----KR 525
Cdd:cd18005 1 LRDYQREGVEFMYDLY--------KNGRGGILGDDMGLGKTVQVIAFLAAVLgktgtrrdrennRPRFKKKPPassakKP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 526 VLVVVPKNVIINWFKEFQKWlvdndeelDTIDVNELDSYKTIEDRRRALKAwhssKTPSVMIIGYDLFRIltvEDDPkkk 605
Cdd:cd18005 73 VLIVAPLSVLYNWKDELDTW--------GHFEVGVYHGSRKDDELEGRLKA----GRLEVVVTTYDTLRR---CIDS--- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 606 kpknrnrrlekakedfrkyLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPG 685
Cdd:cd18005 135 -------------------LNSINWSAVIADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPG 195
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 71980419 686 LLGTKTEFANRFVNIINRGRTKDASPLEVSFMKRRCHVLYDHLKKCVDRK 735
Cdd:cd18005 196 ALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELAVKLSKFFLRR 245
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
463-720 |
1.12e-38 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 144.60 E-value: 1.12e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCAfesLDRLDTEGSGGILAHCMGLGKTLQVITFLHTVLMHEKIGEK--CKRVLVVVPKNVIINWFK 540
Cdd:cd18066 1 LRPHQREGIEFLYECV---MGMRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPYGGKpvIKRALIVTPGSLVKNWKK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 541 EFQKWLVDndeelDTIDVNELDSYKTIEDrrralkaWHSSKTPSVMIIGYDLfrILTVEDDpkkkkpknrnrrlekaked 620
Cdd:cd18066 78 EFQKWLGS-----ERIKVFTVDQDHKVEE-------FIASPLYSVLIISYEM--LLRSLDQ------------------- 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 621 frkyLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNI 700
Cdd:cd18066 125 ----ISKLNFDLVICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEP 200
|
250 260
....*....|....*....|
gi 71980419 701 INRGRTKDASPLEVSFMKRR 720
Cdd:cd18066 201 IVRSREPTATPEEKKLGEAR 220
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
462-720 |
6.32e-36 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 136.16 E-value: 6.32e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 462 ILKPHQAHGIQFMYdcafesldRLDTEGSGGILAHCMGLGKTLQVITFlhtvLMHEKIGEKCKRVLVVVPKNVIINWFKE 541
Cdd:cd18012 4 TLRPYQKEGFNWLS--------FLRHYGLGGILADDMGLGKTLQTLAL----LLSRKEEGRKGPSLVVAPTSLIYNWEEE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 542 FQKWlvdnDEELDTIdvneldSYKTIEDRRRALKAwhsSKTPSVMIIGYDLFRiltveddpkkkkpknrnrrlekakEDF 621
Cdd:cd18012 72 AAKF----APELKVL------VIHGTKRKREKLRA---LEDYDLVITSYGLLR------------------------RDI 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 622 RKYLQNPGpDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNII 701
Cdd:cd18012 115 ELLKEVKF-HYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPI 193
|
250 260
....*....|....*....|....*..
gi 71980419 702 NRGRTKDA--------SPlevsFMKRR 720
Cdd:cd18012 194 EKDGDEEAleelkkliSP----FILRR 216
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
484-1129 |
3.26e-29 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 126.84 E-value: 3.26e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 484 RLDTEGSGGILAHCMGLGKTLQVITFLhtVLMHEKIGEKCKRvLVVVPKNVIINWFKEFQKW--------LVDNDEELDT 555
Cdd:PLN03142 183 RLYENGINGILADEMGLGKTLQTISLL--GYLHEYRGITGPH-MVVAPKSTLGNWMNEIRRFcpvlravkFHGNPEERAH 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 556 IDVNELDSYKtiedrrralkaWHSSKTPSVMIIgydlfriltveddpkkkkpknrnrrleKAKEDFRKYLQNpgpdMVVC 635
Cdd:PLN03142 260 QREELLVAGK-----------FDVCVTSFEMAI---------------------------KEKTALKRFSWR----YIII 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 636 DEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNIINRGRTKDASPLEV- 714
Cdd:PLN03142 298 DEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQQEVVQQLHKv 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 715 --SFMKRRchvlydhLKKCVDRkdyrvlteAIPPKQEYVINVRQTERQCALYNAFLN---DIVGDSGLSKRLLPDYHMFS 789
Cdd:PLN03142 378 lrPFLLRR-------LKSDVEK--------GLPPKKETILKVGMSQMQKQYYKALLQkdlDVVNAGGERKRLLNIAMQLR 442
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 790 RIWTHPYQLvlheqrmerervmredaeeeadfiddgdgsesesegsfkSGSESDsgksvvlssddegsskkkkngnkpei 869
Cdd:PLN03142 443 KCCNHPYLF---------------------------------------QGAEPG-------------------------- 457
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 870 kktapqkkrkflnsddedeedgedtamailqdgirqskrlageeadlrdtdtPPEYTGWFarlgLVKEedrddfalSNKL 949
Cdd:PLN03142 458 ----------------------------------------------------PPYTTGEH----LVEN--------SGKM 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 950 ILLVEIIKKCEEIGDKLLVFSQslesltlIKRMLEYMagtgqwfadghealnaegeETWSWLEGEDYMTIDGSVQSGKRD 1029
Cdd:PLN03142 474 VLLDKLLPKLKERDSRVLIFSQ-------MTRLLDIL-------------------EDYLMYRGYQYCRIDGNTGGEDRD 527
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 1030 AVQTSFNDPlNLRARLMLISTRAGSLGTNMVAANRVIIFDACWNPSHDTQSLFRVYRFGQTKPVYIYRFIAQGTMEERIY 1109
Cdd:PLN03142 528 ASIDAFNKP-GSEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVI 606
|
650 660
....*....|....*....|
gi 71980419 1110 KRQVTKESTSMRVVDEAQIQ 1129
Cdd:PLN03142 607 ERAYKKLALDALVIQQGRLA 626
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
463-687 |
5.48e-29 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 115.11 E-value: 5.48e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDcafesldrLDTEGSGGILAHCMGLGKTLQVITFLhTVLMHEKIGEKckRVLVVVPKNVIINWFKEF 542
Cdd:cd18000 1 LFKYQQTGVQWLWE--------LHCQRVGGILGDEMGLGKTIQIIAFL-AALHHSKLGLG--PSLIVCPATVLKQWVKEF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 543 QKW------LVDNDEELDTIDVNELDSYKTIEDRRRALKawhssKTPSVMIIGYDLFRILtveddpkkkkpknrnrrlek 616
Cdd:cd18000 70 HRWwppfrvVVLHSSGSGTGSEEKLGSIERKSQLIRKVV-----GDGGILITTYEGFRKH-------------------- 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71980419 617 akedfRKYLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLL 687
Cdd:cd18000 125 -----KDLLLNHNWQYVILDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNNLKELWSLFDFVFPPYL 190
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
463-697 |
1.03e-24 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 103.87 E-value: 1.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCAFEsldrldteGSGGILAHCMGLGKTLQVITFLHTVLMHEKIGEKckrVLVVVPKNVIINWFKEF 542
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYN--------RRNCILADEMGLGKTIQSIAFLEHLYQVEGIRGP---FLVIAPLSTIPNWQREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 543 QKWlvdndeeldtIDVNELDSYKTIEDRRRALK----AWHSSKTPSVMIIGYDL----FRILTVEDDpkkkkpknrnrrl 614
Cdd:cd17995 70 ETW----------TDMNVVVYHGSGESRQIIQQyemyFKDAQGRKKKGVYKFDVlittYEMVIADAE------------- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 615 EKAKEDFRkylqnpgpdMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFA 694
Cdd:cd17995 127 ELRKIPWR---------VVVVDEAHRLKNRNSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFL 197
|
...
gi 71980419 695 NRF 697
Cdd:cd17995 198 EEF 200
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
462-697 |
1.10e-24 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 104.39 E-value: 1.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 462 ILKPHQAHGIQFMYdcafesldRLDTEGSGGILAHCMGLGKTLQVITFLhtVLMHEKiGEKCKrVLVVVPKNVIINWFKE 541
Cdd:cd18009 3 VMRPYQLEGMEWLR--------MLWENGINGILADEMGLGKTIQTIALL--AHLRER-GVWGP-FLVIAPLSTLPNWVNE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 542 FQKWlvdndeeldTIDVNELDSYKTIEDRRRaLKAWHSSKTPS-----VMIIGYdlfriltveddpkkkkpknrnrrlEK 616
Cdd:cd18009 71 FARF---------TPSVPVLLYHGTKEERER-LRKKIMKREGTlqdfpVVVTSY------------------------EI 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 617 AKEDfRKYLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANR 696
Cdd:cd18009 117 AMRD-RKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESW 195
|
.
gi 71980419 697 F 697
Cdd:cd18009 196 F 196
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
463-684 |
2.87e-24 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 101.31 E-value: 2.87e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFmydcafesLDRLDTEGSGGILAHCMGLGKTLQVITFLHTVLmheKIGEKCKRvLVVVPKNVIINWFKEF 542
Cdd:cd17998 1 LKDYQLIGLNW--------LNLLYQKKLSGILADEMGLGKTIQVIAFLAYLK---EIGIPGPH-LVVVPSSTLDNWLREF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 543 QKWlvdndeeldTIDVNELDSYKTIEDRRRALKAWHSSKtpsvmiIGYDLfrILTVEDdpkkkkpknrnrrLEKAKEDFR 622
Cdd:cd17998 69 KRW---------CPSLKVEPYYGSQEERKHLRYDILKGL------EDFDV--IVTTYN-------------LATSNPDDR 118
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71980419 623 KYLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKP 684
Cdd:cd17998 119 SFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNFIMP 180
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
463-720 |
4.11e-24 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 101.90 E-value: 4.11e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFmydcafeSLDRldtegsGG--ILAHCMGLGKTLQVITFLHtvlmhekigekCKR----VLVVVPKNVII 536
Cdd:cd18010 1 LLPFQREGVCF-------ALRR------GGrvLIADEMGLGKTVQAIAIAA-----------YYReewpLLIVCPSSLRL 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 537 NWFKEFQKWLvdndEELDTIDVNeldsykTIEDRRRALkawhSSKTPSVMIIGYDLFRILtveddpkkkkpknrnrRLEK 616
Cdd:cd18010 57 TWADEIERWL----PSLPPDDIQ------VIVKSKDGL----RDGDAKVVIVSYDLLRRL----------------EKQL 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 617 AKEDFRkylqnpgpdMVVCDEAHKLKNDDSALSKCMVKIL--TKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFA 694
Cdd:cd18010 107 LARKFK---------VVICDESHYLKNSKAKRTKAALPLLkrAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDFG 177
|
250 260 270
....*....|....*....|....*....|....*.
gi 71980419 695 NRFVNIINRGRTKDASP----------LEVSFMKRR 720
Cdd:cd18010 178 RRYCAAKQGGFGWDYSGssnleelhllLLATIMIRR 213
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
463-713 |
1.26e-23 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 100.89 E-value: 1.26e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMydcAFesldrLDTEGSGGILAHCMGLGKTLQVITFLHTVLMHEKIGEKCK--RVLVVVPKNVIINWFK 540
Cdd:cd17999 1 LRPYQQEGINWL---AF-----LNKYNLHGILCDDMGLGKTLQTLCILASDHHKRANSFNSEnlPSLVVCPPTLVGHWVA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 541 EFQKWLvdnDEELDTIdvneLDSYKTIEDRRRALkawHSSKTPSVMIIGYDLFRiltveddpkkkkpknrnrrleKAKEd 620
Cdd:cd17999 73 EIKKYF---PNAFLKP----LAYVGPPQERRRLR---EQGEKHNVIVASYDVLR---------------------NDIE- 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 621 frkYLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNI 700
Cdd:cd17999 121 ---VLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKP 197
|
250
....*....|...
gi 71980419 701 INRGRTKDASPLE 713
Cdd:cd17999 198 ILASRDSKASAKE 210
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
463-702 |
2.60e-23 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 99.73 E-value: 2.60e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYdcafesldRLDTEGSGGILAHCMGLGKTLQVITFL-HTVLMHEKIGEKckrvLVVVPKNVIINWFKE 541
Cdd:cd18003 1 LREYQHIGLDWLA--------TLYEKNLNGILADEMGLGKTIQTIALLaHLACEKGNWGPH----LIVVPTSVMLNWEME 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 542 FQKWLVdndeeldtiDVNELDSYKTIEDRRRALKAWHSSKTPSVMIIGYDLFriltVEDDPKkkkpknrnrrlekakedF 621
Cdd:cd18003 69 FKRWCP---------GFKILTYYGSAKERKLKRQGWMKPNSFHVCITSYQLV----VQDHQV-----------------F 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 622 R----KYLqnpgpdmvVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRF 697
Cdd:cd18003 119 KrkkwKYL--------ILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWF 190
|
....*
gi 71980419 698 VNIIN 702
Cdd:cd18003 191 SNPLT 195
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
488-693 |
3.48e-23 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 99.32 E-value: 3.48e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 488 EGSGGILAHCMGLGKTLQVITFLHTVLMHEKI-GEKckrvLVVVPKNVIINWFKEFQKWLvdndeelDTIDVNELDSYKt 566
Cdd:cd17997 21 NGINGILADEMGLGKTLQTISLLGYLKHYKNInGPH----LIIVPKSTLDNWMREFKRWC-------PSLRVVVLIGDK- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 567 iEDRRRALKAWHSSKTPSVMIIGYDLFRiltveddpkkkkpknrnrrleKAKEDFRKYlqnpGPDMVVCDEAHKLKNDDS 646
Cdd:cd17997 89 -EERADIIRDVLLPGKFDVCITSYEMVI---------------------KEKTVLKKF----NWRYIIIDEAHRIKNEKS 142
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 71980419 647 ALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEF 693
Cdd:cd17997 143 KLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDF 189
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
463-720 |
7.73e-23 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 98.90 E-value: 7.73e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCafesldrldtegsGGILAHCMGLGKTLQVI--------------TFLHTVLMHEKIGEKCKRVLV 528
Cdd:cd18008 1 LLPYQKQGLAWMLPR-------------GGILADEMGLGKTIQALalilatrpqdpkipEELEENSSDPKKLYLSKTTLI 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 529 VVPKNVIINWFKEFQK--------WLV-------DNDEELDTIDVnELDSYKTIedRRRALKAWHSSKTPSVMIIGYDLF 593
Cdd:cd18008 68 VVPLSLLSQWKDEIEKhtkpgslkVYVyhgskriKSIEELSDYDI-VITTYGTL--ASEFPKNKKGGGRDSKEKEASPLH 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 594 RIltveddpkkkkpknrnrrlekakEDFRkylqnpgpdmVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLM 673
Cdd:cd18008 145 RI-----------------------RWYR----------VILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLD 191
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 71980419 674 EYHCMVNFVKPGLLG----TKTEFANRFVNIINRGRTKDASPLEvSFMKRR 720
Cdd:cd18008 192 DLYSLLRFLRVEPFGdypwFNSDISKPFSKNDRKALERLQALLK-PILLRR 241
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
463-697 |
3.41e-21 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 93.97 E-value: 3.41e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCAFESLDrldtegsgGILAHCMGLGKTLQVITFLhTVLMHEK--IGEkckrVLVVVPKNVIINWFK 540
Cdd:cd17996 4 LKEYQLKGLQWMVSLYNNNLN--------GILADEMGLGKTIQTISLI-TYLMEKKknNGP----YLVIVPLSTLSNWVS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 541 EFQKWLvdndEELDTIdvneldSYKTIEDRRRALKAWHSSKTPSVMIIGYDLfrilTVEDdpkkkkpknrNRRLEKAKed 620
Cdd:cd17996 71 EFEKWA----PSVSKI------VYKGTPDVRKKLQSQIRAGKFNVLLTTYEY----IIKD----------KPLLSKIK-- 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71980419 621 fRKYlqnpgpdMVVcDEAHKLKNDDSALSKCMVK-ILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRF 697
Cdd:cd17996 125 -WKY-------MII-DEGHRMKNAQSKLTQTLNTyYHARYRLLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWF 193
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
487-720 |
4.75e-21 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 93.19 E-value: 4.75e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 487 TEGSGGILAHCMGLGKTLQVITFL----HTVLMHEKIgekckrvLVVVPKNVIINWFKEFQKWLVDNDEELDTIDVNELD 562
Cdd:cd17993 18 CKGNNGILADEMGLGKTVQTISFLsylfHSQQQYGPF-------LVVVPLSTMPAWQREFAKWAPDMNVIVYLGDIKSRD 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 563 SYKTIEdrrralkaWHSSKTP----SVMIIGYDLfrILtveddpkkkkpknrnrrleKAKEDFRK----YLqnpgpdMVv 634
Cdd:cd17993 91 TIREYE--------FYFSQTKklkfNVLLTTYEI--IL-------------------KDKAFLGSikwqYL------AV- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 635 cDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGllgtKTEFANRFVNIINRGRTKDASPLEV 714
Cdd:cd17993 135 -DEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPG----KFDIWEEFEEEHDEEQEKGIADLHK 209
|
....*....
gi 71980419 715 ---SFMKRR 720
Cdd:cd17993 210 elePFILRR 218
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
493-705 |
2.15e-18 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 85.83 E-value: 2.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 493 ILAHCMGLGKTLQVITFLHTVL-MHEKIGEkckrVLVVVPKNVIINWFKEFQKWLVDNDEeldTIDVNELDSYKTIEDRR 571
Cdd:cd18054 43 ILADEMGLGKTIQTISFLSYLFhQHQLYGP----FLLVVPLSTLTSWQREFEIWAPEINV---VVYIGDLMSRNTIREYE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 572 ralkaWHSSKTP----SVMIIGYDLFriltVEDdpkkkkpknrnrrlekakedfRKYLQNPGPDMVVCDEAHKLKNDDSA 647
Cdd:cd18054 116 -----WIHSQTKrlkfNALITTYEIL----LKD---------------------KTVLGSINWAFLGVDEAHRLKNDDSL 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 71980419 648 LSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPgllgTKTEFANRFVNIINRGR 705
Cdd:cd18054 166 LYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMP----EKFEFWEDFEEDHGKGR 219
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
463-685 |
2.99e-18 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 84.47 E-value: 2.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCafesldrldteGSGGILAHCMGLGKTLQVITFLHTVLMHekigEKCKRVLVVVP-KNVIINWFKE 541
Cdd:smart00487 9 LRPYQKEAIEALLSG-----------LRDVILAAPTGSGKTLAALLPALEALKR----GKGGRVLVLVPtRELAEQWAEE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 542 FQKWLvdndEELDTIDVNELDSYKTIEDRRRALkawhsSKTPSVMIIGYDLFRILtveddpkkkkpknrnrrLEKAKEDF 621
Cdd:smart00487 74 LKKLG----PSLGLKVVGLYGGDSKREQLRKLE-----SGKTDILVTTPGRLLDL-----------------LENDKLSL 127
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 622 RKYlqnpgpDMVVCDEAHKLKNDD-SALSKCMVKIL--TKRRICLTGTPLQN--NLMEYHC-MVNFVKPG 685
Cdd:smart00487 128 SNV------DLVILDEAHRLLDGGfGDQLEKLLKLLpkNVQLLLLSATPPEEieNLLELFLnDPVFIDVG 191
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
463-697 |
1.40e-17 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 83.32 E-value: 1.40e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCaFEsldrldtEGSGGILAHCMGLGKTLQVITFLHTVLMHEKIGEKckrVLVVVPKNVIINWFKEF 542
Cdd:cd18002 1 LKEYQLKGLNWLANL-YE-------QGINGILADEMGLGKTVQSIAVLAHLAEEHNIWGP---FLVIAPASTLHNWQQEI 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 543 QKWLVDndeeldtidVNELDSYKTIEDRRRALKAWHSSKTPS------VMIIGYDLfrilTVEDDpkkkkpknrnrrlek 616
Cdd:cd18002 70 SRFVPQ---------FKVLPYWGNPKDRKVLRKFWDRKNLYTrdapfhVVITSYQL----VVQDE--------------- 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 617 akedfrKYLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANR 696
Cdd:cd18002 122 ------KYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEW 195
|
.
gi 71980419 697 F 697
Cdd:cd18002 196 F 196
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
463-697 |
8.86e-17 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 81.64 E-value: 8.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDcafesldrLDTEGSGGILAHCMGLGKTLQVITFLHTVLMHEKIGEKCkrvLVVVPKNVIINWFKEF 542
Cdd:cd18064 16 LRDYQVRGLNWLIS--------LYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPH---MVLVPKSTLHNWMAEF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 543 QKWlvdndeeldtidVNELDSYKTIEDRRRALKAWHSSKTP---SVMIIGYDLfriltveddpkkkkpknrnrrLEKAKE 619
Cdd:cd18064 85 KRW------------VPTLRAVCLIGDKDQRAAFVRDVLLPgewDVCVTSYEM---------------------LIKEKS 131
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71980419 620 DFRKYlqnpGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRF 697
Cdd:cd18064 132 VFKKF----NWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWF 205
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
463-699 |
1.16e-16 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 80.56 E-value: 1.16e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCAfesldrldTEGSGGILAHCMGLGKTLQVITFLhtvlMHEKIGEKCKR-VLVVVPKNVIINWFKE 541
Cdd:cd18006 1 LRPYQLEGVNWLLQCR--------AEQHGCILGDEMGLGKTCQTISLL----WYLAGRLKLLGpFLVLCPLSVLDNWKEE 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 542 FQKWLVDndeeLDTIDVNElDSYKTIEDRR--RALKAWHssktpsVMIIGYDlfrILTVEDDpkkkkpknrnrrlekake 619
Cdd:cd18006 69 LNRFAPD----LSVITYMG-DKEKRLDLQQdiKSTNRFH------VLLTTYE---ICLKDAS------------------ 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 620 dfrkYLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTefANRFVN 699
Cdd:cd18006 117 ----FLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEPNVFPKDK--LDDFIK 190
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
463-720 |
6.10e-16 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 77.86 E-value: 6.10e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCAfesldrldTEGSGGILAHCMGLGKTLQVITFLHTvLMHEkiGEKCKRVLVVVPKNVIINWFKEF 542
Cdd:cd17994 1 LHPYQLEGLNWLRFSW--------AQGTDTILADEMGLGKTIQTIVFLYS-LYKE--GHSKGPFLVSAPLSTIINWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 543 QKWLVDndeeldtidvneLDSYKTIEDRrralkawhssktpsVMIIGYDLFRIltveddpkkkkpknrnrrlEKAkedfr 622
Cdd:cd17994 70 EMWAPD------------FYVVTYVGDH--------------VLLTSYELISI-------------------DQA----- 99
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 623 kYLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNIIN 702
Cdd:cd17994 100 -ILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFADISK 178
|
250
....*....|....*...
gi 71980419 703 RGRTKDASPLEVSFMKRR 720
Cdd:cd17994 179 EDQIKKLHDLLGPHMLRR 196
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
493-720 |
7.10e-16 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 78.16 E-value: 7.10e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 493 ILAHCMGLGKTLQVITFLHTVLMHEKIGEkckrVLVVVPKNVIINWFKEFQKWlvdndEELDTIdvneldsyktiedrrr 572
Cdd:cd18058 23 ILADEMGLGKTIQSITFLSEIFLMGIRGP----FLIIAPLSTITNWEREFRTW-----TEMNAI---------------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 573 alkAWHSSKTPSVMIIGYDLF-RILTVEDDPKKKKPKNRNRRLEKAKEDFRKyLQNPGPDMVVCDEAHKLKNDDSALSKC 651
Cdd:cd18058 78 ---VYHGSQISRQMIQQYEMYyRDEQGNPLSGIFKFQVVITTFEMILADCPE-LKKINWSCVIIDEAHRLKNRNCKLLEG 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71980419 652 MVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNIINRGRTKDASPLEVSFMKRR 720
Cdd:cd18058 154 LKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDLKTEEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
463-720 |
1.22e-15 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 77.80 E-value: 1.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMydcafesldRLD-TEGSGGILAHCMGLGKTLQVITFLHTVLmheKIGEKCKRVLVVVPKNVIINWFKE 541
Cdd:cd18057 1 LHPYQLEGLNWL---------RFSwAQGTDTILADEMGLGKTVQTIVFLYSLY---KEGHSKGPYLVSAPLSTIINWERE 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 542 FQKWLVD--------NDEELDTIDVNELdsykTIEDR--RRALKAWHSSKTPS----VMIIGYDLFRIltveddpkkkkP 607
Cdd:cd18057 69 FEMWAPDfyvvtytgDKESRSVIRENEF----SFEDNaiRSGKKVFRMKKEAQikfhVLLTSYELITI-----------D 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 608 KNRNRRLEKAkedfrkylqnpgpdMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLL 687
Cdd:cd18057 134 QAILGSIEWA--------------CLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERF 199
|
250 260 270
....*....|....*....|....*....|...
gi 71980419 688 GTKTEFANRFVNIINRGRTKDASPLEVSFMKRR 720
Cdd:cd18057 200 NNLEGFLEEFADISKEDQIKKLHDLLGPHMLRR 232
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
488-684 |
1.63e-15 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 77.78 E-value: 1.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 488 EGSGGILAHCMGLGKTLQVITFLHtVLMHEKigEKCKRVLVVVPKNVIINWFKEFQKWLVDNDEELDTIDVNELDSYKTI 567
Cdd:cd18053 38 KGNSCILADEMGLGKTIQTISFLN-YLFHEH--QLYGPFLLVVPLSTLTSWQREIQTWAPQMNAVVYLGDINSRNMIRTH 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 568 EdrrralkaWHSSKTP----SVMIIGYDLFriltVEDdpkkkkpknrnrrlekakedfRKYLQNPGPDMVVCDEAHKLKN 643
Cdd:cd18053 115 E--------WMHPQTKrlkfNILLTTYEIL----LKD---------------------KSFLGGLNWAFIGVDEAHRLKN 161
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 71980419 644 DDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKP 684
Cdd:cd18053 162 DDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMP 202
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
463-697 |
2.07e-15 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 77.37 E-value: 2.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDcafesldrLDTEGSGGILAHCMGLGKTLQVITFLHTVLMHEKIGEKCkrvLVVVPKNVIINWFKEF 542
Cdd:cd18065 16 LRDYQVRGLNWMIS--------LYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPH---MVLVPKSTLHNWMNEF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 543 QKWLVDNDEELDTIDVNELDSYktIEDRRRAlKAWHSSKTPSVMIIgydlfriltveddpkkkkpknrnrrleKAKEDFR 622
Cdd:cd18065 85 KRWVPSLRAVCLIGDKDARAAF--IRDVMMP-GEWDVCVTSYEMVI---------------------------KEKSVFK 134
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71980419 623 KYLQNpgpdMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRF 697
Cdd:cd18065 135 KFNWR----YLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWF 205
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
488-720 |
2.49e-15 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 76.97 E-value: 2.49e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 488 EGSGGILAHCMGLGKTLQVITFLHTVLmheKIGEKCKRVLVVVPKNVIINWFKEFQKWLVD--------NDEELDTIDVN 559
Cdd:cd18055 18 QGTDTILADEMGLGKTIQTIVFLYSLY---KEGHTKGPFLVSAPLSTIINWEREFQMWAPDfyvvtytgDKDSRAIIREN 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 560 ELDSYKT-IEDRRRALKAWHSSKTP-SVMIIGYDLfriLTVEddpkkkkpknrnrrlekakedfRKYLQNPGPDMVVCDE 637
Cdd:cd18055 95 EFSFDDNaVKGGKKAFKMKREAQVKfHVLLTSYEL---VTID----------------------QAALGSIRWACLVVDE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 638 AHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNIINRGRTKDASPLEVSFM 717
Cdd:cd18055 150 AHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHM 229
|
...
gi 71980419 718 KRR 720
Cdd:cd18055 230 LRR 232
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
493-720 |
2.94e-15 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 76.61 E-value: 2.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 493 ILAHCMGLGKTLQVITFLHTVLMHEKIGEkckrVLVVVPKNVIINWFKEFQKWlvdndEELDTIdvneldSYKTIEDRRR 572
Cdd:cd18059 23 ILADEMGLGKTIQSITFLYEIYLKGIHGP----FLVIAPLSTIPNWEREFRTW-----TELNVV------VYHGSQASRR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 573 ALKAWHSS-KTPSVMII--GYDLFRILTVEDdpkkkkpknrnRRLEKAKEdfrkyLQNPGPDMVVCDEAHKLKNDDSALS 649
Cdd:cd18059 88 TIQLYEMYfKDPQGRVIkgSYKFHAIITTFE-----------MILTDCPE-----LRNIPWRCVVIDEAHRLKNRNCKLL 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71980419 650 KCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNIINRGRTKDASPLEVSFMKRR 720
Cdd:cd18059 152 EGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
463-722 |
3.95e-15 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 76.64 E-value: 3.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMYDCAFESLDrldtegsgGILAHCMGLGKTLQVITFLHTVLMHEKIGEKckrVLVVVPKNVIINWFKEF 542
Cdd:cd18063 24 LKHYQLQGLEWMVSLYNNNLN--------GILADEMGLGKTIQTIALITYLMEHKRLNGP---YLIIVPLSTLSNWTYEF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 543 QKWlvdndeELDTIDVneldSYKTIEDRRRALKAWHSSKTPSVMIIGYDLFriltVEDdpkkkkpknrNRRLEKAKedfR 622
Cdd:cd18063 93 DKW------APSVVKI----SYKGTPAMRRSLVPQLRSGKFNVLLTTYEYI----IKD----------KHILAKIR---W 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 623 KYLqnpgpdmvVCDEAHKLKNDDSALSKCM-VKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRF-VNI 700
Cdd:cd18063 146 KYM--------IVDEGHRMKNHHCKLTQVLnTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFnAPF 217
|
250 260
....*....|....*....|..
gi 71980419 701 INRGRTKDASPLEVSFMKRRCH 722
Cdd:cd18063 218 AMTGERVDLNEEETILIIRRLH 239
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
462-722 |
2.00e-14 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 74.70 E-value: 2.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 462 ILKPHQAHGIQFMYDCAFESLDrldtegsgGILAHCMGLGKTLQVITFLHTVLMHEKIGEKckrVLVVVPKNVIINWFKE 541
Cdd:cd18062 23 VLKQYQIKGLEWLVSLYNNNLN--------GILADEMGLGKTIQTIALITYLMEHKRINGP---FLIIVPLSTLSNWVYE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 542 FQKWlvdndeELDTIDVneldSYKTIEDRRRALKAWHSSKTPSVMIIGYDLFriltVEDdpkkkkpknrNRRLEKAKedf 621
Cdd:cd18062 92 FDKW------APSVVKV----SYKGSPAARRAFVPQLRSGKFNVLLTTYEYI----IKD----------KQILAKIR--- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 622 RKYLqnpgpdmvVCDEAHKLKNDDSALSKCM-VKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRF-VN 699
Cdd:cd18062 145 WKYM--------IVDEGHRMKNHHCKLTQVLnTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFnAP 216
|
250 260
....*....|....*....|...
gi 71980419 700 IINRGRTKDASPLEVSFMKRRCH 722
Cdd:cd18062 217 FAMTGEKVDLNEEETILIIRRLH 239
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
493-719 |
6.96e-14 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 71.94 E-value: 6.96e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 493 ILAHCMGLGKTLQVITFLHtvlMHEKIGEkCKRVLVVVPKNVIINWFKEFQKWLVDNDEELDTidvnelDSYKTIedRRR 572
Cdd:cd18011 21 LLADEVGLGKTIEAGLIIK---ELLLRGD-AKRVLILCPASLVEQWQDELQDKFGLPFLILDR------ETAAQL--RRL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 573 ALKAWHsskTPSVMIIGYDLFriltveddpkkkkpknrnrrleKAKEDFRKYLQNPGPDMVVCDEAHKLKN----DDSAL 648
Cdd:cd18011 89 IGNPFE---EFPIVIVSLDLL----------------------KRSEERRGLLLSEEWDLVVVDEAHKLRNsgggKETKR 143
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71980419 649 SKCMVKI--LTKRRICLTGTPLQNNLMEYHCMVNFVKPGLlgtkteFANRFVNIINRGRTKDASPLevsFMKR 719
Cdd:cd18011 144 YKLGRLLakRARHVLLLTATPHNGKEEDFRALLSLLDPGR------FAVLGRFLRLDGLREVLAKV---LLRR 207
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
463-720 |
7.82e-14 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 72.41 E-value: 7.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMydcafesldRLD-TEGSGGILAHCMGLGKTLQVITFLHTVLmheKIGEKCKRVLVVVPKNVIINWFKE 541
Cdd:cd18056 1 LHPYQLEGLNWL---------RFSwAQGTDTILADEMGLGKTVQTAVFLYSLY---KEGHSKGPFLVSAPLSTIINWERE 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 542 FQKWLVD--------NDEELDTIDVNELdsykTIEDR--RRALKAWHSSKTPSV----MIIGYDLFRILTVeddpkkkkp 607
Cdd:cd18056 69 FEMWAPDmyvvtyvgDKDSRAIIRENEF----SFEDNaiRGGKKASRMKKEASVkfhvLLTSYELITIDMA--------- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 608 knrnrrlekakedfrkYLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLL 687
Cdd:cd18056 136 ----------------ILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERF 199
|
250 260 270
....*....|....*....|....*....|...
gi 71980419 688 GTKTEFANRFVNIINRGRTKDASPLEVSFMKRR 720
Cdd:cd18056 200 HNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRR 232
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
489-683 |
3.71e-13 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 70.58 E-value: 3.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 489 GSGGILAHCMGLGKTLQVITFLHTvlmhekigekcKRVLVVVPKNVIINWFKEFQkwlvdndeelDTIDVNELDSYktie 568
Cdd:cd18071 48 VRGGILADDMGLGKTLTTISLILA-----------NFTLIVCPLSVLSNWETQFE----------EHVKPGQLKVY---- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 569 drrralkAWH-SSKTPSV-MIIGYDL----FRILTVEDDpkkkkpknrnrrlekAKEDfrKYLQNPGPDMVVCDEAHKLK 642
Cdd:cd18071 103 -------TYHgGERNRDPkLLSKYDIvlttYNTLASDFG---------------AKGD--SPLHTINWLRVVLDEGHQIR 158
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 71980419 643 NDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVK 683
Cdd:cd18071 159 NPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSFLH 199
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
493-720 |
8.82e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 69.31 E-value: 8.82e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 493 ILAHCMGLGKTLQVITFLHTVLmheKIGEKCKrVLVVVPKNVIINWFKEFQKWlvdndEELDTIdvneldsyktiedrrr 572
Cdd:cd18060 23 ILADEMGLGKTIQSIAFLQEVY---NVGIHGP-FLVIAPLSTITNWEREFNTW-----TEMNTI---------------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 573 alkAWHSSKTPSVMIIGYDLFriltVEDDPKKKKPKNRNrrLEKAKEDFRKYLQNpGPDM-------VVCDEAHKLKNDD 645
Cdd:cd18060 78 ---VYHGSLASRQMIQQYEMY----CKDSRGRLIPGAYK--FDALITTFEMILSD-CPELreiewrcVIIDEAHRLKNRN 147
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71980419 646 SALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNIINRGRTKDASPLEVSFMKRR 720
Cdd:cd18060 148 CKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
947-1088 |
2.96e-12 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 64.54 E-value: 2.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 947 NKLILLVEIIKKceEIGDKLLVFSQSlesltliKRMLEymagtgqwfadghealnaegEETWSWLEGEDYMTIDGSVQSG 1026
Cdd:pfam00271 1 EKLEALLELLKK--ERGGKVLIFSQT-------KKTLE--------------------AELLLEKEGIKVARLHGDLSQE 51
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71980419 1027 KRDAVQTSFNDPlnlrARLMLISTRAGSLGTNMVAANRVIIFDACWNPSHDTQSLFRVYRFG 1088
Cdd:pfam00271 52 EREEILEDFRKG----KIDVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1013-1088 |
4.90e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 63.00 E-value: 4.90e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71980419 1013 GEDYMTIDGSVQSGKRDAVQTSFNDPLNLrarlMLISTRAGSLGTNMVAANRVIIFDACWNPSHDTQSLFRVYRFG 1088
Cdd:smart00490 11 GIKVARLHGGLSQEEREEILDKFNNGKIK----VLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
463-674 |
4.16e-11 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 64.29 E-value: 4.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMydcafesldrLDTEGSGGILAhcMGLGKTLQVITFLHTVLMHEKIGekckRVLVVVPKNVIIN-WFKE 541
Cdd:cd18013 1 PHPYQKVAINFI----------IEHPYCGLFLD--MGLGKTVTTLTALSDLQLDDFTR----RVLVIAPLRVARStWPDE 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 542 FQKWlvdndEELDTIDVNELDSYKTieDRRRALKawhssKTPSVMIIGYDLFRILtveddpkkkkpknrnrrLEKAKEDF 621
Cdd:cd18013 65 VEKW-----NHLRNLTVSVAVGTER--QRSKAAN-----TPADLYVINRENLKWL-----------------VNKSGDPW 115
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 71980419 622 rkylqnpgP-DMVVCDEAHKLKNDDSALSKCMVKI--LTKRRICLTGTPLQNNLME 674
Cdd:cd18013 116 --------PfDMVVIDELSSFKSPRSKRFKALRKVrpVIKRLIGLTGTPSPNGLMD 163
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
493-720 |
2.52e-10 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 61.95 E-value: 2.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 493 ILAHCMGLGKTLQVITFLHTVLMHEKIGEkckrVLVVVPKNVIINWFKEFQKWlvdndeeldtIDVNELDSYKTIEDRR- 571
Cdd:cd18061 23 ILADEMGLGKTIQSITFLYEILLTGIRGP----FLIIAPLSTIANWEREFRTW----------TDLNVVVYHGSLISRQm 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 572 -RALKAWHSSKTPSVMIIGYDLFRILTVEDdpkkkkpKNRNRRLEKAKEDFRkylqnpgpdMVVCDEAHKLKNDDSALSK 650
Cdd:cd18061 89 iQQYEMYFRDSQGRIIRGAYRFQAIITTFE-------MILGGCPELNAIDWR---------CVIIDEAHRLKNKNCKLLE 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 651 CMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNIINRGRTKDASPLEVSFMKRR 720
Cdd:cd18061 153 GLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
463-683 |
1.38e-05 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 48.25 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 463 LKPHQAHGIQFMydcafesLDRLDTEGSGGILAHCMGLGKTLQVITFLHTVLMHEKIGEKCKR----------------- 525
Cdd:cd18072 1 LLLHQKQALAWL-------LWRERQKPRGGILADDMGLGKTLTMIALILAQKNTQNRKEEEKEkalteweskkdstlvps 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 526 --VLVVVPKNVIINWFKEFQKWLVDNDEELDTIDVNELDSyktiedRRRALKAWhssktpSVMIIGYDLFriltveddpk 603
Cdd:cd18072 74 agTLVVCPASLVHQWKNEVESRVASNKLRVCLYHGPNRER------IGEVLRDY------DIVITTYSLV---------- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980419 604 kkkpknrNRRLEKAKEDFRkylQNPGPDM----VVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMV 679
Cdd:cd18072 132 -------AKEIPTYKEESR---SSPLFRIawarIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLL 201
|
....
gi 71980419 680 NFVK 683
Cdd:cd18072 202 KFLR 205
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
1047-1099 |
6.39e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 39.61 E-value: 6.39e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 71980419 1047 LISTRAGSLGTNMVAANRVIIFDACWNPSHDTQSLFRVYRFGQtKPVYIYRFI 1099
Cdd:cd18785 26 LVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGK-DEGEVILFV 77
|
|
| |
