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Conserved domains on  [gi|70887585|ref|NP_001020656|]
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coiled-coil domain-containing protein 22 [Danio rerio]

Protein Classification

coiled-coil domain-containing protein 22( domain architecture ID 12064803)

coiled-coil domain-containing protein 22 (CCDC22) is a DUF812 domain-containing protein that is involved in regulation of NF-kappa-B signaling

Gene Symbol:  CCDC22
PubMed:  33942254

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 1-609 0e+00

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


:

Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 873.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585     1 MEEVDRILIHSLRQAGTDIDEDVQSVKQFTSELIVEAVVRCLRVIDPAVGNGLSHSLPPGMSARFRLGMSLAQACQDVGF 80
Cdd:pfam05667   1 MEEVDGIIIHSLRQIGCEIAEDVQSLKDFTTELLVEAVVRCLRVINPDLGINLPLTLPPGMSARFRVGTSLAQACQELGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585    81 KGEIGYQTFLYSNEPEIRSLFMFLVERLPRESAEASDQPAGKSVLLQRAIAAQIKAQLSVPWLPPTCRLpvHRKTQSSGP 160
Cdd:pfam05667  81 RGEIGYQTFLYPNEPDIRKILMFLVEKLPRESSEAADQPVGKSAVLQRAIAAAIRSQLAAPWLPPECKP--HQRRQGSRA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   161 CHSFHAQPLSLPCSlKVSSRKQPKEVQEYWRNYLLPVTAQPSQPASVPASLLENHISELSAAQEWESEWNSQGLLSRLTP 240
Cdd:pfam05667 159 LRPFHTQTLVLPGR-KGKTLKNSKELKEFYSEYLPPVTAQPSSRASVVPSLLERNAAELAAAQEWEEEWNSQGLASRLTP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   241 EEYRSRKKARLQKRIEEQLRTAAQPRPDTH-GATRSTSDLAELLQSFGGASTGGDVLTKGTRFTHTEKFTFTQEPEKAVq 319
Cdd:pfam05667 238 EEYRKRKRTKLLKRIAEQLRSAALAGTEATsGASRSAQDLAELLSSFSGSSTTDTGLTKGSRFTHTEKLQFTNEAPAAT- 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   320 qmaaaaSALPSSQQSEEDLKAQQEAELSALQQQLQQLSVQMEEVGGGIKQLTVSIQQVTDELQTREVTNAERENSVKIKR 399
Cdd:pfam05667 317 ------SSPPTKVETEEELQQQREEELEELQEQLEDLESSIQELEKEIKKLESSIKQVEEELEELKEQNEELEKQYKVKK 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   400 QTIDLLPDAENNLLKLQSLVESSSKRVVQLASQWEKHRVPLIDEHRRLKELCSNRESESSRKLSEIKDLHDKIRQSAEEA 479
Cdd:pfam05667 391 KTLDLLPDAEENIAKLQALVDASAQRLVELAGQWEKHRVPLIEEYRALKEAKSNKEDESQRKLEEIKELREKIKEVAEEA 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   480 KKKESLYKQLLTEFETLSKDVSRSAYTIRILEIVGNIKKQKEEITKILSDTKDLQKEINGLTGKLDRTFAVTDELVFKDA 559
Cdd:pfam05667 471 KQKEELYKQLVAEYERLPKDVSRSAYTRRILEIVKNIKKQKEEITKILSDTKSLQKEINSLTGKLDRTFTVTDELVFKDA 550

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|
gi 70887585   560 KKDESVRKSYKYLAALHENCTQLIQTIEDTGTIMREIRDLEEQIETENGK 609
Cdd:pfam05667 551 KKDESVRKAYKYLAALHENCEQLIQTVEETGTIMREIRDLEEQIETESGK 600
 
Name Accession Description Interval E-value
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 1-609 0e+00

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 873.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585     1 MEEVDRILIHSLRQAGTDIDEDVQSVKQFTSELIVEAVVRCLRVIDPAVGNGLSHSLPPGMSARFRLGMSLAQACQDVGF 80
Cdd:pfam05667   1 MEEVDGIIIHSLRQIGCEIAEDVQSLKDFTTELLVEAVVRCLRVINPDLGINLPLTLPPGMSARFRVGTSLAQACQELGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585    81 KGEIGYQTFLYSNEPEIRSLFMFLVERLPRESAEASDQPAGKSVLLQRAIAAQIKAQLSVPWLPPTCRLpvHRKTQSSGP 160
Cdd:pfam05667  81 RGEIGYQTFLYPNEPDIRKILMFLVEKLPRESSEAADQPVGKSAVLQRAIAAAIRSQLAAPWLPPECKP--HQRRQGSRA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   161 CHSFHAQPLSLPCSlKVSSRKQPKEVQEYWRNYLLPVTAQPSQPASVPASLLENHISELSAAQEWESEWNSQGLLSRLTP 240
Cdd:pfam05667 159 LRPFHTQTLVLPGR-KGKTLKNSKELKEFYSEYLPPVTAQPSSRASVVPSLLERNAAELAAAQEWEEEWNSQGLASRLTP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   241 EEYRSRKKARLQKRIEEQLRTAAQPRPDTH-GATRSTSDLAELLQSFGGASTGGDVLTKGTRFTHTEKFTFTQEPEKAVq 319
Cdd:pfam05667 238 EEYRKRKRTKLLKRIAEQLRSAALAGTEATsGASRSAQDLAELLSSFSGSSTTDTGLTKGSRFTHTEKLQFTNEAPAAT- 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   320 qmaaaaSALPSSQQSEEDLKAQQEAELSALQQQLQQLSVQMEEVGGGIKQLTVSIQQVTDELQTREVTNAERENSVKIKR 399
Cdd:pfam05667 317 ------SSPPTKVETEEELQQQREEELEELQEQLEDLESSIQELEKEIKKLESSIKQVEEELEELKEQNEELEKQYKVKK 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   400 QTIDLLPDAENNLLKLQSLVESSSKRVVQLASQWEKHRVPLIDEHRRLKELCSNRESESSRKLSEIKDLHDKIRQSAEEA 479
Cdd:pfam05667 391 KTLDLLPDAEENIAKLQALVDASAQRLVELAGQWEKHRVPLIEEYRALKEAKSNKEDESQRKLEEIKELREKIKEVAEEA 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   480 KKKESLYKQLLTEFETLSKDVSRSAYTIRILEIVGNIKKQKEEITKILSDTKDLQKEINGLTGKLDRTFAVTDELVFKDA 559
Cdd:pfam05667 471 KQKEELYKQLVAEYERLPKDVSRSAYTRRILEIVKNIKKQKEEITKILSDTKSLQKEINSLTGKLDRTFTVTDELVFKDA 550

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|
gi 70887585   560 KKDESVRKSYKYLAALHENCTQLIQTIEDTGTIMREIRDLEEQIETENGK 609
Cdd:pfam05667 551 KKDESVRKAYKYLAALHENCEQLIQTVEETGTIMREIRDLEEQIETESGK 600
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
396-638 1.53e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 51.60  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585  396 KIKRQT--IDLLPDAENNLLKLQSLVESSSKRVVQLASQWEKhrvplidehrrLKELCSNRESESSRKLSEIKDLHDKIR 473
Cdd:PRK03918 149 KVVRQIlgLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTEN-----------IEELIKEKEKELEEVLREINEISSELP 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585  474 QSAEEAKKKESLYKQLLTEFETLSKdvsrsaYTIRILEIVGNIKKQKEEITKILSDTKDLQKEINGLtgkldrtfavtdE 553
Cdd:PRK03918 218 ELREELEKLEKEVKELEELKEEIEE------LEKELESLEGSKRKLEEKIRELEERIEELKKEIEEL------------E 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585  554 LVFKDAKKDESVRKSYKYLAALHENCTQLIQTIEDT-GTIMREIRDLEEQIETENGKrtVSNLEKILEDYKAIRQENSAL 632
Cdd:PRK03918 280 EKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRlSRLEEEINGIEERIKELEEK--EERLEELKKKLKELEKRLEEL 357


                 ....*.
gi 70887585  633 AAKIRE 638
Cdd:PRK03918 358 EERHEL 363
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 398-638 6.22e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.12  E-value: 6.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585    398 KRQTIDLLPDAENNLLKLQSLVESSSKRVVQLASQWEKhrvplideHRRLKELcSNRESESSRKLS--EIKDLHDKIRQS 475
Cdd:TIGR02168  174 RKETERKLERTRENLDRLEDILNELERQLKSLERQAEK--------AERYKEL-KAELRELELALLvlRLEELREELEEL 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585    476 AEEAKKKESLYKQLLTEFETLSKDVSRSaytirILEIvGNIKKQKEEITKILsdtKDLQKEINGLTGkldrtfavtdELV 555
Cdd:TIGR02168  245 QEELKEAEEELEELTAELQELEEKLEEL-----RLEV-SELEEEIEELQKEL---YALANEISRLEQ----------QKQ 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585    556 FKDAKKDESVRKSYKYLAALHENCTQLIQTIEDTGTIMREIRDLEEQIETENGK-----RTVSNLEKILEDY-KAIRQEN 629
Cdd:TIGR02168  306 ILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAEleeleAELEELESRLEELeEQLETLR 385


                   ....*....
gi 70887585    630 SALAAKIRE 638
Cdd:TIGR02168  386 SKVAQLELQ 394
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 312-560 1.63e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 1.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585 312 QEPEKAVQQMAAAASALPSSQQSEEDLKAQ---QEAELSALQQQLQQLSVQMEEVGGGIKQLTVSIQQVTDELQTREVTN 388
Cdd:COG4942  27 AELEQLQQEIAELEKELAALKKEEKALLKQlaaLERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEEL 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585 389 AERENSV-KIKRQTIDLLpdaennLLKLQSLVESSskRVVQLASQWEKHRVPLIDEHRRlkelcsnresessrklsEIKD 467
Cdd:COG4942 107 AELLRALyRLGRQPPLAL------LLSPEDFLDAV--RRLQYLKYLAPARREQAEELRA-----------------DLAE 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585 468 LHDKIRQSAEEAKKKESLYKQLLTEFETLSKDVSRSAYTIRILEivGNIKKQKEEITKILSDTKDLQKEINGLTGKLDRT 547
Cdd:COG4942 162 LAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLE--KELAELAAELAELQQEAEELEALIARLEAEAAAA 239

                       250
                ....*....|...
gi 70887585 548 FAVTDELVFKDAK 560
Cdd:COG4942 240 AERTPAAGFAALK 252
 
Name Accession Description Interval E-value
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 1-609 0e+00

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 873.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585     1 MEEVDRILIHSLRQAGTDIDEDVQSVKQFTSELIVEAVVRCLRVIDPAVGNGLSHSLPPGMSARFRLGMSLAQACQDVGF 80
Cdd:pfam05667   1 MEEVDGIIIHSLRQIGCEIAEDVQSLKDFTTELLVEAVVRCLRVINPDLGINLPLTLPPGMSARFRVGTSLAQACQELGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585    81 KGEIGYQTFLYSNEPEIRSLFMFLVERLPRESAEASDQPAGKSVLLQRAIAAQIKAQLSVPWLPPTCRLpvHRKTQSSGP 160
Cdd:pfam05667  81 RGEIGYQTFLYPNEPDIRKILMFLVEKLPRESSEAADQPVGKSAVLQRAIAAAIRSQLAAPWLPPECKP--HQRRQGSRA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   161 CHSFHAQPLSLPCSlKVSSRKQPKEVQEYWRNYLLPVTAQPSQPASVPASLLENHISELSAAQEWESEWNSQGLLSRLTP 240
Cdd:pfam05667 159 LRPFHTQTLVLPGR-KGKTLKNSKELKEFYSEYLPPVTAQPSSRASVVPSLLERNAAELAAAQEWEEEWNSQGLASRLTP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   241 EEYRSRKKARLQKRIEEQLRTAAQPRPDTH-GATRSTSDLAELLQSFGGASTGGDVLTKGTRFTHTEKFTFTQEPEKAVq 319
Cdd:pfam05667 238 EEYRKRKRTKLLKRIAEQLRSAALAGTEATsGASRSAQDLAELLSSFSGSSTTDTGLTKGSRFTHTEKLQFTNEAPAAT- 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   320 qmaaaaSALPSSQQSEEDLKAQQEAELSALQQQLQQLSVQMEEVGGGIKQLTVSIQQVTDELQTREVTNAERENSVKIKR 399
Cdd:pfam05667 317 ------SSPPTKVETEEELQQQREEELEELQEQLEDLESSIQELEKEIKKLESSIKQVEEELEELKEQNEELEKQYKVKK 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   400 QTIDLLPDAENNLLKLQSLVESSSKRVVQLASQWEKHRVPLIDEHRRLKELCSNRESESSRKLSEIKDLHDKIRQSAEEA 479
Cdd:pfam05667 391 KTLDLLPDAEENIAKLQALVDASAQRLVELAGQWEKHRVPLIEEYRALKEAKSNKEDESQRKLEEIKELREKIKEVAEEA 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   480 KKKESLYKQLLTEFETLSKDVSRSAYTIRILEIVGNIKKQKEEITKILSDTKDLQKEINGLTGKLDRTFAVTDELVFKDA 559
Cdd:pfam05667 471 KQKEELYKQLVAEYERLPKDVSRSAYTRRILEIVKNIKKQKEEITKILSDTKSLQKEINSLTGKLDRTFTVTDELVFKDA 550

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|
gi 70887585   560 KKDESVRKSYKYLAALHENCTQLIQTIEDTGTIMREIRDLEEQIETENGK 609
Cdd:pfam05667 551 KKDESVRKAYKYLAALHENCEQLIQTVEETGTIMREIRDLEEQIETESGK 600
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
396-638 1.53e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 51.60  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585  396 KIKRQT--IDLLPDAENNLLKLQSLVESSSKRVVQLASQWEKhrvplidehrrLKELCSNRESESSRKLSEIKDLHDKIR 473
Cdd:PRK03918 149 KVVRQIlgLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTEN-----------IEELIKEKEKELEEVLREINEISSELP 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585  474 QSAEEAKKKESLYKQLLTEFETLSKdvsrsaYTIRILEIVGNIKKQKEEITKILSDTKDLQKEINGLtgkldrtfavtdE 553
Cdd:PRK03918 218 ELREELEKLEKEVKELEELKEEIEE------LEKELESLEGSKRKLEEKIRELEERIEELKKEIEEL------------E 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585  554 LVFKDAKKDESVRKSYKYLAALHENCTQLIQTIEDT-GTIMREIRDLEEQIETENGKrtVSNLEKILEDYKAIRQENSAL 632
Cdd:PRK03918 280 EKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRlSRLEEEINGIEERIKELEEK--EERLEELKKKLKELEKRLEEL 357


                 ....*.
gi 70887585  633 AAKIRE 638
Cdd:PRK03918 358 EERHEL 363
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 372-638 2.40e-06

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 50.70  E-value: 2.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585  372 VSIQQVTDELQTREVTNAeRENSVKIKRqTIDLLPDAENNLLKLQSLVESSSKRvvqlasqwekhrvplidehrRLKELC 451
Cdd:PRK05771  31 VHIEDLKEELSNERLRKL-RSLLTKLSE-ALDKLRSYLPKLNPLREEKKKVSVK--------------------SLEELI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585  452 SNRESESSRKLSEIKDLHDKIRQSAEEAKKKESLyKQLLTEFETLSKDVSRSAYTIRILEIVGNIKKQKEEITKILSDtK 531
Cdd:PRK05771  89 KDVEEELEKIEKEIKELEEEISELENEIKELEQE-IERLEPWGNFDLDLSLLLGFKYVSVFVGTVPEDKLEELKLESD-V 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585  532 DLQKEINglTGKLDRTFAVTDElvFKDAKKDESVRKSYKYLAalhenctqliQTIEDTGTIMREIRDLEEQIETENGKRt 611
Cdd:PRK05771 167 ENVEYIS--TDKGYVYVVVVVL--KELSDEVEEELKKLGFER----------LELEEEGTPSELIREIKEELEEIEKER- 231

                        250       260
                 ....*....|....*....|....*..
gi 70887585  612 vsnlEKILEDYKAIRQENSALAAKIRE 638
Cdd:PRK05771 232 ----ESLLEELKELAKKYLEELLALYE 254
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
440-639 9.73e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.44  E-value: 9.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585  440 LIDEHRRLKELCSNR---ESESSRKLSEIKDLHDKIRQ----SAEEAKKKESLYKQLLTEFETLSKDVSRsaytIRILEi 512
Cdd:PRK03918 544 LKKELEKLEELKKKLaelEKKLDELEEELAELLKELEElgfeSVEELEERLKELEPFYNEYLELKDAEKE----LEREE- 618

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585  513 vGNIKKQKEEITKILSDTKDLQKEINGLTGKLDRTFAVTDELVFKDaKKDESVRKSyKYLAALHENCTQLIQTIEdtgTI 592
Cdd:PRK03918 619 -KELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEE-LREEYLELS-RELAGLRAELEELEKRRE---EI 692

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 70887585  593 MREIRDLEEQIET-ENGKRTVSNLEKILEDYKAIRQENSALAAKIREG 639
Cdd:PRK03918 693 KKTLEKLKEELEErEKAKKELEKLEKALERVEELREKVKKYKALLKER 740
PTZ00121 PTZ00121
MAEBL; Provisional
 246-638 1.74e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.13  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   246 RKKARLQKRIEEqLRTAAQPRPDTHGATRSTSDLAELLQSfggastgGDVLTKGTRFTHTEKFTFTQEPEKAVQQMAAAA 325
Cdd:PTZ00121 1503 KKAAEAKKKADE-AKKAEEAKKADEAKKAEEAKKADEAKK-------AEEKKKADELKKAEELKKAEEKKKAEEAKKAEE 1574

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   326 SALPSSQQSEEDLKAQQEAELSALQQQLQQLSVQMEEVGGGiKQLTVSIQQVTDELQTREVTNAERENSVKIKRQTIDLL 405
Cdd:PTZ00121 1575 DKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA-EEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELK 1653

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   406 PDAENNLLKLQSLV--ESSSKRVVQLASQWEkhrvplidEHRRLKELCSNRESESSRKLSEIKDLHDKIRQSAEEAKKKE 483
Cdd:PTZ00121 1654 KAEEENKIKAAEEAkkAEEDKKKAEEAKKAE--------EDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAE 1725

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   484 SLYKQLLTEFETLSKDVSRSAYTIRILEivGNIKK----QKEEITKILSDTKDLQKEINGLTGKLDRTFAVTDELVFKDA 559
Cdd:PTZ00121 1726 EENKIKAEEAKKEAEEDKKKAEEAKKDE--EEKKKiahlKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDI 1803

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   560 KKD-----ESVRKSYKYLAALHENCTQLIQTIEDTGTIMREIRDLEEQ----IETENGKRTVSNLEKILEDYKAIRQENS 630
Cdd:PTZ00121 1804 FDNfaniiEGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEADAFEKhkfnKNNENGEDGNKEADFNKEKDLKEDDEEE 1883


                  ....*...
gi 70887585   631 ALAAKIRE 638
Cdd:PTZ00121 1884 IEEADEIE 1891
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 398-638 6.22e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.12  E-value: 6.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585    398 KRQTIDLLPDAENNLLKLQSLVESSSKRVVQLASQWEKhrvplideHRRLKELcSNRESESSRKLS--EIKDLHDKIRQS 475
Cdd:TIGR02168  174 RKETERKLERTRENLDRLEDILNELERQLKSLERQAEK--------AERYKEL-KAELRELELALLvlRLEELREELEEL 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585    476 AEEAKKKESLYKQLLTEFETLSKDVSRSaytirILEIvGNIKKQKEEITKILsdtKDLQKEINGLTGkldrtfavtdELV 555
Cdd:TIGR02168  245 QEELKEAEEELEELTAELQELEEKLEEL-----RLEV-SELEEEIEELQKEL---YALANEISRLEQ----------QKQ 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585    556 FKDAKKDESVRKSYKYLAALHENCTQLIQTIEDTGTIMREIRDLEEQIETENGK-----RTVSNLEKILEDY-KAIRQEN 629
Cdd:TIGR02168  306 ILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAEleeleAELEELESRLEELeEQLETLR 385


                   ....*....
gi 70887585    630 SALAAKIRE 638
Cdd:TIGR02168  386 SKVAQLELQ 394
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 312-560 1.63e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 1.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585 312 QEPEKAVQQMAAAASALPSSQQSEEDLKAQ---QEAELSALQQQLQQLSVQMEEVGGGIKQLTVSIQQVTDELQTREVTN 388
Cdd:COG4942  27 AELEQLQQEIAELEKELAALKKEEKALLKQlaaLERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEEL 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585 389 AERENSV-KIKRQTIDLLpdaennLLKLQSLVESSskRVVQLASQWEKHRVPLIDEHRRlkelcsnresessrklsEIKD 467
Cdd:COG4942 107 AELLRALyRLGRQPPLAL------LLSPEDFLDAV--RRLQYLKYLAPARREQAEELRA-----------------DLAE 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585 468 LHDKIRQSAEEAKKKESLYKQLLTEFETLSKDVSRSAYTIRILEivGNIKKQKEEITKILSDTKDLQKEINGLTGKLDRT 547
Cdd:COG4942 162 LAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLE--KELAELAAELAELQQEAEELEALIARLEAEAAAA 239

                       250
                ....*....|...
gi 70887585 548 FAVTDELVFKDAK 560
Cdd:COG4942 240 AERTPAAGFAALK 252
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 332-637 1.86e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.54  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   332 QQSEEDLKAQQEAELSALQQQLQQLSVQMEEVGGGIKQLTVSIQQVTDELQTREVTNAERENSVKIKRQTI-DLLPDAEN 410
Cdd:TIGR04523 302 NQKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIeKLKKENQS 381

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   411 NLLKLQSLVESSSKRVVQLASQ-------------WEKHRVPLIDEHRRLKEL-------CSNRESESSRKLSEIKDLHD 470
Cdd:TIGR04523 382 YKQEIKNLESQINDLESKIQNQeklnqqkdeqikkLQQEKELLEKEIERLKETiiknnseIKDLTNQDSVKELIIKNLDN 461

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   471 KIRQSAEEAKKKESLYKQLLTEFETLSKDVSR-----SAYTIRILEIVGNIKKQKEEITKILSDTKDLQKEINGLTGKLD 545
Cdd:TIGR04523 462 TRESLETQLKVLSRSINKIKQNLEQKQKELKSkekelKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKIS 541

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   546 --RTFAVTDELVFKDAKKDESVRKSYKYLAALHENCTQLIQTIEDTGTIMR----EIRDLEEQIETENgkRTVSNLEKIL 619
Cdd:TIGR04523 542 dlEDELNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDqkekEKKDLIKEIEEKE--KKISSLEKEL 619

                         330
                  ....*....|....*...
gi 70887585   620 EDykaIRQENSALAAKIR 637
Cdd:TIGR04523 620 EK---AKKENEKLSSIIK 634
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 368-624 2.51e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.16  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   368 KQLTVSIQQVTDELQTREVTNAERENSVKIKRQTIDLLPDAENNLLKLQSLVESSSKRVVQLASQWEKHRVPLIDEHRRL 447
Cdd:TIGR04523  36 KQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKND 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   448 KELCSNRESESSRKLSEIKDLHDKIRQSAEEAKKKESLYKQLLTEFETLSKDVSRSAYTIRILE--------IVGNIKKQ 519
Cdd:TIGR04523 116 KEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEkeklniqkNIDKIKNK 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585   520 KEEITKILSDTKDLQKEINGLTGKLDRTFAVTDELvfKDAKKDESVRKSYKYlAALHENCTQLIQTIEDTGTIMREIRDL 599
Cdd:TIGR04523 196 LLKLELLLSNLKKKIQKNKSLESQISELKKQNNQL--KDNIEKKQQEINEKT-TEISNTQTQLNQLKDEQNKIKKQLSEK 272

                         250       260
                  ....*....|....*....|....*
gi 70887585   600 EEQIETENGKrtVSNLEKILEDYKA 624
Cdd:TIGR04523 273 QKELEQNNKK--IKELEKQLNQLKS 295
46 PHA02562
endonuclease subunit; Provisional
 367-571 8.18e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 39.23  E-value: 8.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585  367 IKQLTVSIQQVTDELQTREVTNAERENSVKikrqtidllpDAENNLLKLQSLVESSSKrvvqLASQWEKHRV-PLidehr 445
Cdd:PHA02562 229 AKTIKAEIEELTDELLNLVMDIEDPSAALN----------KLNTAAAKIKSKIEQFQK----VIKMYEKGGVcPT----- 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585  446 rlkelCSNRESESSRKLSEIKDLHDKIRQSAEEAKKKESLYKQLLTEFETLSKdvsrsaytiRILEIVGNIKKQKEEITK 525
Cdd:PHA02562 290 -----CTQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSK---------KLLELKNKISTNKQSLIT 355

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 70887585  526 ILSDTKDLQKEINGLTGK-LDRTFAVT---DELVFKDAKKDESVRKSYKY 571
Cdd:PHA02562 356 LVDKAKKVKAAIEELQAEfVDNAEELAklqDELDKIVKTKSELVKEKYHR 405
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 360-637 8.27e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 39.33  E-value: 8.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585    360 MEEVGGGIKQLTVSIQQVTDELqtrEVTNAERENSVKIkrqtidLLPDAENNLLKLQSLVESSSKRVVQLASQWEKHRVP 439
Cdd:pfam15921  226 LRELDTEISYLKGRIFPVEDQL---EALKSESQNKIEL------LLQQHQDRIEQLISEHEVEITGLTEKASSARSQANS 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585    440 LIDEHRRLKELCSNRESESSRKLSEIKDLHDKIRQSAEEAK-----KKESLYKQL------LTEFETLSKDVSRSAYTI- 507
Cdd:pfam15921  297 IQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKrmyedKIEELEKQLvlanseLTEARTERDQFSQESGNLd 376

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585    508 -RILEIVGNIKKQKEEITKILSDTKDLQKE-------INGLTGKL-DRTFAVTDELVFKDAKKDESVRKSYKYLAALH-- 576
Cdd:pfam15921  377 dQLQKLLADLHKREKELSLEKEQNKRLWDRdtgnsitIDHLRRELdDRNMEVQRLEALLKAMKSECQGQMERQMAAIQgk 456

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 70887585    577 ----ENCTQLIQTIEDTGTIMREIRD--LEEQIETENGKRTVSNLEKIL-EDYKAIRQENSALaAKIR 637
Cdd:pfam15921  457 neslEKVSSLTAQLESTKEMLRKVVEelTAKKMTLESSERTVSDLTASLqEKERAIEATNAEI-TKLR 523
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
400-547 9.89e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 38.35  E-value: 9.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887585 400 QTIDLLPDAENNLLKlqslvessskRVVQLASQWEKhRVPLIDEHRRLKELcsnrESESSRKLSEIKDLHDKIRQSAEEA 479
Cdd:COG1340 126 QTEVLSPEEEKELVE----------KIKELEKELEK-AKKALEKNEKLKEL----RAELKELRKEAEEIHKKIKELAEEA 190

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 70887585 480 KKKESLYKQLLTEFETLSKdvSRSAYTIRILEIVGNIKKQKEEITKILSDTKDLQKEINGLTGKLDRT 547
Cdd:COG1340 191 QELHEEMIELYKEADELRK--EADELHKEIVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRAL 256
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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