NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|67078490|ref|NP_001019937|]
View 

WD repeat-containing protein 5B [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-327 7.65e-107

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 317.62  E-value: 7.65e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  30 ALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKLWD 109
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 110 VRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLC 189
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 190 RIWDAASGQCLRTLADEGNpPVSFVKFSPNGKYILTATLDSTLKLWDYSRGRCLKTYTGHKNEKYCIfaSFSVTGRkWVV 269
Cdd:COG2319 271 RLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGK-TLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 67078490 270 SGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTENIIASAAleNDKTIKIWSSD 327
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-327 7.65e-107

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 317.62  E-value: 7.65e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  30 ALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKLWD 109
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 110 VRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLC 189
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 190 RIWDAASGQCLRTLADEGNpPVSFVKFSPNGKYILTATLDSTLKLWDYSRGRCLKTYTGHKNEKYCIfaSFSVTGRkWVV 269
Cdd:COG2319 271 RLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGK-TLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 67078490 270 SGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTENIIASAAleNDKTIKIWSSD 327
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-325 5.15e-103

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 303.87  E-value: 5.15e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  31 LRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKLWDV 110
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 111 RSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCR 190
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 191 IWDAASGQCLRTLADEgNPPVSFVKFSPNGKYILTATLDSTLKLWDYSRGRCLKTYTGHKNekYCIFASFSVTGRkWVVS 270
Cdd:cd00200 161 LWDLRTGKCVATLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFSPDGY-LLAS 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 67078490 271 GSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTENIIASAALenDKTIKIWS 325
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 35-281 1.04e-15

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 77.82  E-value: 1.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490   35 LAGHSAAISSVKFSPNGEWLASSAADALIIIWgaydgKCKKT-------------LYGHSlEISDVAWSSD-SSRLVSAS 100
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIF-----ECESIikdgrdihypvveLASRS-KLSGICWNSYiKSQVASSN 552

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  101 DDKTLKLWDVRSGKCLKTLKGHSDFVFCCDFNPPS-NLIVSGSFDESVKIWEVKTGKCLKTLSAHSDpISAVHFHCN-GS 178
Cdd:PLN00181 553 FEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGR 631

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  179 LIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFSPNGKYILTATlDSTLKLWDYSRGRC------LKTYTGHKNE 252
Cdd:PLN00181 632 SLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNV 710

                        250       260
                 ....*....|....*....|....*....
gi 67078490  253 KYciFASFSVTGrKWVVSGSEDNMVYIWN 281
Cdd:PLN00181 711 KN--FVGLSVSD-GYIATGSETNEVFVYH 736
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 154-193 2.55e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.01  E-value: 2.55e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 67078490    154 TGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCRIWD 193
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
155-193 1.13e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.13e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 67078490   155 GKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCRIWD 193
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-327 7.65e-107

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 317.62  E-value: 7.65e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  30 ALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKLWD 109
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 110 VRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLC 189
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 190 RIWDAASGQCLRTLADEGNpPVSFVKFSPNGKYILTATLDSTLKLWDYSRGRCLKTYTGHKNEKYCIfaSFSVTGRkWVV 269
Cdd:COG2319 271 RLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGK-TLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 67078490 270 SGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTENIIASAAleNDKTIKIWSSD 327
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-325 5.15e-103

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 303.87  E-value: 5.15e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  31 LRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKLWDV 110
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 111 RSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCR 190
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 191 IWDAASGQCLRTLADEgNPPVSFVKFSPNGKYILTATLDSTLKLWDYSRGRCLKTYTGHKNekYCIFASFSVTGRkWVVS 270
Cdd:cd00200 161 LWDLRTGKCVATLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFSPDGY-LLAS 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 67078490 271 GSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTENIIASAALenDKTIKIWS 325
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
30-325 4.28e-98

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 295.28  E-value: 4.28e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  30 ALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKLWD 109
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 110 VRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLC 189
Cdd:COG2319 149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 190 RIWDAASGQCLRTLADEGNpPVSFVKFSPNGKYILTATLDSTLKLWDYSRGRCLKTYTGHKNEKYCIfaSFSVTGRkWVV 269
Cdd:COG2319 229 RLWDLATGKLLRTLTGHSG-SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFSPDGK-LLA 304

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 67078490 270 SGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTENIIASAAleNDKTIKIWS 325
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS--DDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
31-284 7.66e-88

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 269.09  E-value: 7.66e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  31 LRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKLWDV 110
Cdd:COG2319 154 LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 111 RSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCR 190
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 191 IWDAASGQCLRTLADEGNPPVSfVKFSPNGKYILTATLDSTLKLWDYSRGRCLKTYTGHKNEKYCIfaSFSVTGRkWVVS 270
Cdd:COG2319 314 LWDLATGKLLRTLTGHTGAVRS-VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV--AFSPDGR-TLAS 389

                       250
                ....*....|....
gi 67078490 271 GSEDNMVYIWNLQT 284
Cdd:COG2319 390 GSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
30-325 1.93e-85

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 262.92  E-value: 1.93e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  30 ALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKLWD 109
Cdd:COG2319  27 ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 110 VRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLC 189
Cdd:COG2319 107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 190 RIWDAASGQCLRTLADEGNpPVSFVKFSPNGKYILTATLDSTLKLWDYSRGRCLKTYTGHKNEKYCIfaSFSVTGRkWVV 269
Cdd:COG2319 187 RLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV--AFSPDGR-LLA 262

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 67078490 270 SGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTENIIASAAleNDKTIKIWS 325
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS--DDGTVRLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
47-325 8.13e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 220.17  E-value: 8.13e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  47 FSPNGEWLASSAADALIIIWGAYDGKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSDFV 126
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 127 FCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCRIWDAASGQCLRTLADE 206
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 207 GNPPVSfVKFSPNGKYILTATLDSTLKLWDYSRGRCLKTYTGHKNEKYCIfaSFSVTGRkWVVSGSEDNMVYIWNLQTKE 286
Cdd:COG2319 162 SGAVTS-VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGK-LLASGSADGTVRLWDLATGK 237

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 67078490 287 IVQRLQGHTDVVISAACHPTENIIASAAleNDKTIKIWS 325
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPDGRLLASGS--ADGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 27-193 1.92e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 176.76  E-value: 1.92e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  27 PNYALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLK 106
Cdd:cd00200 123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 107 LWDVRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYD 186
Cdd:cd00200 203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                ....*..
gi 67078490 187 GLCRIWD 193
Cdd:cd00200 283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
88-325 4.15e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.94  E-value: 4.15e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  88 AWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDP 167
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 168 ISAVHFHCNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSfVKFSPNGKYILTATLDSTLKLWDYSRGRCLKTYT 247
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRS-VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67078490 248 GHKNEKYCIfaSFSVTGrKWVVSGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTENIIASAAleNDKTIKIWS 325
Cdd:COG2319 160 GHSGAVTSV--AFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS--ADGTVRLWD 232
WD40 COG2319
WD40 repeat [General function prediction only];
30-112 8.65e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 8.65e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  30 ALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKLWD 109
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                ...
gi 67078490 110 VRS 112
Cdd:COG2319 401 LAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 35-281 1.04e-15

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 77.82  E-value: 1.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490   35 LAGHSAAISSVKFSPNGEWLASSAADALIIIWgaydgKCKKT-------------LYGHSlEISDVAWSSD-SSRLVSAS 100
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIF-----ECESIikdgrdihypvveLASRS-KLSGICWNSYiKSQVASSN 552

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  101 DDKTLKLWDVRSGKCLKTLKGHSDFVFCCDFNPPS-NLIVSGSFDESVKIWEVKTGKCLKTLSAHSDpISAVHFHCN-GS 178
Cdd:PLN00181 553 FEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGR 631

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  179 LIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFSPNGKYILTATlDSTLKLWDYSRGRC------LKTYTGHKNE 252
Cdd:PLN00181 632 SLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNV 710

                        250       260
                 ....*....|....*....|....*....
gi 67078490  253 KYciFASFSVTGrKWVVSGSEDNMVYIWN 281
Cdd:PLN00181 711 KN--FVGLSVSD-GYIATGSETNEVFVYH 736
PTZ00421 PTZ00421
coronin; Provisional
 77-197 4.71e-12

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 66.45  E-value: 4.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490   77 LYGHSLEISDVAWSS-DSSRLVSASDDKTLKLWDV-------RSGKCLKTLKGHSDFVFCCDFNPPS-NLIVSGSFDESV 147
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVV 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 67078490  148 KIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCRIWDAASG 197
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 154-193 2.55e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.01  E-value: 2.55e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 67078490    154 TGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCRIWD 193
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 112-151 1.05e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 1.05e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 67078490    112 SGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWE 151
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
155-193 1.13e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.13e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 67078490   155 GKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCRIWD 193
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 70-109 1.21e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 1.21e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 67078490     70 DGKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKLWD 109
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
71-109 4.18e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 4.18e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 67078490    71 GKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKLWD 109
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 35-153 4.22e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 57.60  E-value: 4.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490   35 LAGHSAAISSVKFSPNGE-WLASSAADALIIIWGAYDGKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG 113
Cdd:PTZ00421 121 LQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 67078490  114 KCLKTLKGH-SDFVFCCDFNPPSNLIVSGSFDES----VKIWEVK 153
Cdd:PTZ00421 201 TIVSSVEAHaSAKSQRCLWAKRKDLIITLGCSKSqqrqIMLWDTR 245
WD40 pfam00400
WD domain, G-beta repeat;
113-151 6.26e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 6.26e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 67078490   113 GKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWE 151
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 138-318 2.02e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.48  E-value: 2.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  138 IVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVHFH-CNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNppVSFVKF 216
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSsADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQF 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  217 -SPNGKYILTATLDSTLKLWDYSRGRC-LKTYTGH-KNEKYCIFASFSVtgrkwVVSGSEDNMVYIWNLQ------TKEI 287
Cdd:PLN00181 626 pSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHsKTVSYVRFVDSST-----LVSSSTDNTLKLWDLSmsisgiNETP 700

                        170       180       190
                 ....*....|....*....|....*....|.
gi 67078490  288 VQRLQGHTDVVISAACHPTENIIASAALEND 318
Cdd:PLN00181 701 LHSFMGHTNVKNFVGLSVSDGYIATGSETNE 731
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 113-311 2.05e-08

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 55.08  E-value: 2.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490   113 GKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLK-----------------------TLSAHSDPIS 169
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEkrsrntqtefprkdhviaetpfhILCGHDDIIT 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490   170 AVHFHCNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFSPNGKYILTATLDSTLKLwdYSrgrclktytgh 249
Cdd:pfam20426 194 CLYVSVELDIVISGSKDGTCIFHTLREGRYVRSIRHPSGCPLSKLVASRHGRIVLYADDDLSLHL--YS----------- 260

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67078490   250 KNEKYciFASFSVTGR----------KWVVSGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTENIIA 311
Cdd:pfam20426 261 INGKH--IASSESNGRlncielsscgEFLVCAGDQGQIVVRSMNSLEVVRRYNGIGKIITSLTVTPEECFLA 330
PTZ00421 PTZ00421
coronin; Provisional
 35-164 6.93e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.74  E-value: 6.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490   35 LAGHSAAISSVKFSP-NGEWLASSAADALIIIWG-AYDGKCKKT------LYGHSLEISDVAW-SSDSSRLVSASDDKTL 105
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGLTQNIsdpivhLQGHTKKVGIVSFhPSAMNVLASAGADMVV 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 67078490  106 KLWDVRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAH 164
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 109-324 5.23e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 5.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  109 DVRSGKCLKTlkghSDFVFCCDFNPPSNLIVSGSFDESVKIWE----VKTGKCLK----TLSAHSDPISAVHFHCNGSLI 180
Cdd:PLN00181 473 DLKQGDLLNS----SNLVCAIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIHypvvELASRSKLSGICWNSYIKSQV 548

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  181 VSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFSPNGKYILTATLDSTLKLWDYSRGRCLKTYTGHKNekYCIFASF 260
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQFP 626

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 67078490  261 SVTGRKwVVSGSEDNMVYIWNLQTKEI-VQRLQGHTDVVISAACHPTENIIASAaleNDKTIKIW 324
Cdd:PLN00181 627 SESGRS-LAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSSS---TDNTLKLW 687
WD40 pfam00400
WD domain, G-beta repeat;
34-66 5.55e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 5.55e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 67078490    34 TLAGHSAAISSVKFSPNGEWLASSAADALIIIW 66
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 34-66 9.37e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 9.37e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 67078490     34 TLAGHSAAISSVKFSPNGEWLASSAADALIIIW 66
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 77-156 1.98e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.10  E-value: 1.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490   77 LYGHSLEISDVAWSSDSSR-LVSASDDKTLKLWDVR----SGKCLK----TLKGHSDFVFCCDFNPPSNLIV-SGSFDES 146
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEiLASGSEDLTIRVWEIPhndeSVKEIKdpqcILKGHKKKISIIDWNPMNYYIMcSSGFDSF 149

                         90
                 ....*....|
gi 67078490  147 VKIWEVKTGK 156
Cdd:PTZ00420 150 VNIWDIENEK 159
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 284-325 3.89e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 67078490    284 TKEIVQRLQGHTDVVISAACHPTENIIASAAleNDKTIKIWS 325
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS--DDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 196-236 4.60e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 4.60e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 67078490    196 SGQCLRTLADEGNPpVSFVKFSPNGKYILTATLDSTLKLWD 236
Cdd:smart00320   1 SGELLKTLKGHTGP-VTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
137-284 5.25e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.91  E-value: 5.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 137 LIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNPpvSFVKF 216
Cdd:COG3391  82 LYVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGP--HGIAV 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490 217 SPNGKYILTATLDST-----LKLWDYSRGRCLKTYTGHKNekyCIFASFSVTGRK-WVV------SGSEDNMVYIWNLQT 284
Cdd:COG3391 160 DPDGKRLYVANSGSNtvsviVSVIDTATGKVVATIPVGGG---PVGVAVSPDGRRlYVAnrgsntSNGGSNTVSVIDLAT 236
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 112-197 1.36e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 43.14  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490   112 SGKCLKTLKGHSDfvfccdfnppSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCRI 191
Cdd:pfam20426  81 GAQCFATLQTPSE----------NFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMV 150


                  ....*.
gi 67078490   192 WDAASG 197
Cdd:pfam20426 151 WEVLRG 156
PTZ00420 PTZ00420
coronin; Provisional
 119-193 1.39e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  119 LKGHSDFVFCCDFNPP-SNLIVSGSFDESVKIW----------EVKTGKCLktLSAHSDPISAVHFH-CNGSLIVSGSYD 186
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWeiphndesvkEIKDPQCI--LKGHKKKISIIDWNpMNYYIMCSSGFD 147


                 ....*..
gi 67078490  187 GLCRIWD 193
Cdd:PTZ00420 148 SFVNIWD 154
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 79-185 1.92e-04

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 42.44  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490    79 GHSlEISDVAWSSDSSRLVSASDDKTLKLW-----DVRSGKCLKTLKGH-----SDFVFCCDFNPPSN------LIVSGS 142
Cdd:pfam16529 185 EHS-LLVDAAFSPDGTALATASLDGEVKFFqiylfDNRNPRCLHEWKPHdgkplSSLFFLDNHKKPPEvqfwrfAITGAD 263

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 67078490   143 FDESVKIWEVKTGKCLKTLSAHSDPISAVHFHC-NGSLIVSGSY 185
Cdd:pfam16529 264 NNSELKLWSCESWTCLQTIRFVPDPPSSLQPPNlKAGLDLSANY 307
WD40 pfam00400
WD domain, G-beta repeat;
240-281 1.96e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 1.96e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 67078490   240 GRCLKTYTGHKNEKYCIfaSFSVTGrKWVVSGSEDNMVYIWN 281
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSL--AFSPDG-KLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
197-236 2.49e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.49e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 67078490   197 GQCLRTLADEGNPpVSFVKFSPNGKYILTATLDSTLKLWD 236
Cdd:pfam00400   1 GKLLKTLEGHTGS-VTSLAFSPDGKLLASGSDDGTVKVWD 39
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
211-275 2.66e-04

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 42.32  E-value: 2.66e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67078490 211 VSFVKFSPNGKYILTATLDsTLKLWDYSRGR-CLKTYTGHKN---------EKYCIFASFSVT---GRKWVVSGSEDN 275
Cdd:COG5170 283 ISDFKFSDNGRYILSRDYL-TVKIWDVNMAKnPIKTIPMHCDlmdelndvyENDAIFDKFEISfsgDDKHVLSGSYSN 359
WD40 pfam00400
WD domain, G-beta repeat;
285-325 9.76e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 9.76e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 67078490   285 KEIVQRLQGHTDVVISAACHPTENIIASAAleNDKTIKIWS 325
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGS--DDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 79-128 9.87e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.64  E-value: 9.87e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 67078490    79 GHSLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSDFVFC 128
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITC 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 240-281 1.16e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.16e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 67078490    240 GRCLKTYTGHKNEKYCIfaSFSVTGrKWVVSGSEDNMVYIWN 281
Cdd:smart00320   2 GELLKTLKGHTGPVTSV--AFSPDG-KYLASGSDDGTIKLWD 40
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
84-154 2.44e-03

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 39.63  E-value: 2.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  84 ISDVAWSsDSSRLVSASDDKTLKLWDVRSGK-CLKTLKGHSDFV---------------FCCDFNPPSNLIVSGSFDESV 147
Cdd:COG5170 283 ISDFKFS-DNGRYILSRDYLTVKIWDVNMAKnPIKTIPMHCDLMdelndvyendaifdkFEISFSGDDKHVLSGSYSNNF 361


                ....*..
gi 67078490 148 KIWEVKT 154
Cdd:COG5170 362 GIYPTDS 368
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 33-92 3.10e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 3.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490    33 LTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTLYGHSLEISDVAWSSD 92
Cdd:pfam12894  32 LSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 40-224 4.08e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 38.87  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490   40 AAISSVKFSPNGEWLA-SSAAD---ALIIIwGAYDGKCKKTL-YGHSLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGK 114
Cdd:COG4946  343 VRERLPAWSPDGKSIAyFSDASgeyELYIA-PADGSGEPKQLtLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLASGK 421

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67078490  115 C---LKTLKGHSDFVFccDFNPPSNLIV----SGSFDESVKIWEVKTGKclktlsAHsdPISavhfhcngslivsgsyDG 187
Cdd:COG4946  422 VrkvDTDGYGDGISDL--AWSPDSKWLAyskpGPNQLSQIFLYDVETGK------TV--QLT----------------DG 475

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 67078490  188 lcriwdaasgqclrtLADEGNPpvsfvKFSPNGKYIL 224
Cdd:COG4946  476 ---------------RYDDGSP-----AFSPDGKYLY 492
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 288-327 6.14e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 37.70  E-value: 6.14e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 67078490 288 VQRLQGHTDVVISAACHPTENIIASAAleNDKTIKIWSSD 327
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGS--GDGTIKVWDLE 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH