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Conserved domains on  [gi|66347845|ref|NP_001018098|]
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intermembrane lipid transfer protein VPS13C isoform 2B [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3-1366 3.85e-90

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 330.31  E-value: 3.85e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845    3 LESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLTLKIPWKNLYGEAVVAT 82
Cdd:COG5043    2 LEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   83 LEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEeaLQKAAEKGTHSgefiyglenfvykdikpgrkrkkhkkhfkk 162
Cdd:COG5043   82 IEDIYLLISPQAKNSLTREELPQSQQALKQRQLDSWE--ILRETLEESSS------------------------------ 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  163 pfkgldrskdKPKEAKKDTFVEKLATQVIKNVQVKITDIHIKYED-DVTDPKRPLSFGVTLGELSLLTANEHWTPCILNE 241
Cdd:COG5043  130 ----------SPNISRKQSFIESLITKLIDNIQIYIEDIHLRFEDnLSADLEGPYSFGLTLYSLRATSTDASWTEYFVST 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  242 ADKIIYKLIRLDSLSAYWnvnCSMSYQRSREQILDQLKNEILTSGNIPPNY-QYIFQPISASAKLYMNPYAESELktPKL 320
Cdd:COG5043  200 DSSCIHKLITLDYFSIYW---CEISPCITTEDIDSYLENFQPMIAEKSPAYnEYILKPVRGTAKVSINKLPTDEI--PRL 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  321 DCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVL-EVHIRRYtqMWSWSNIK 399
Cdd:COG5043  275 RGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFLKYRPKSTPKEKPLEWFKYIILVVLdSIHEKRY--HWTWKYFK 352

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  400 KHRQLLKSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVfniilarQQAQVEVIRSGQKLRKKSA--DTGEKRGGWFSGL 477
Cdd:COG5043  353 ERCEDRRAYMKIIRKKYLNEQLSADLSKELEKRELTYDL-------IKYRSRLFRSLAKRRNSIYlkPQTHKLQGWFSGL 425

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  478 WGKKESKkkdeeslipETIDDLMTPEEKDKLFTAIG----YSESTHNLTLPKQYVAHIMTLKLVSTSVTIRENKNIPEIL 553
Cdd:COG5043  426 WNGKPQA---------QDEDTLASTDKTAAELTDQEqkdfFSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLI 496

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  554 KIQIIGLGTQVS-QRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPV 632
Cdd:COG5043  497 SQRFENFKSKFSlNKLDLFDGATNPELKPYRSIRNKPKVRESESLQEIEEESRTHLFASFEDSKPDGKASSTLIIHLRTL 576

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  633 EVIYDAKTVNAVVEFFQS--NKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQtGFHHEK 710
Cdd:COG5043  577 VIFYNRVCILSVLKFFVPsrTKIEHVSEWVYSAAATVMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPE-DCTDPK 655

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  711 SDLLILDFGTFQLNSKDQGLQKT-TNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRfQHPSTMHILQPMDIHVE 789
Cdd:COG5043  656 SPTLFLDAGRISIHSQLVEDAIIkKFRELQTLENLMYDRFTISLFNVRCLIGPDYEGKRELP-KGKCDYHILKELKLEIN 734

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  790 LAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIpLPQKSSAQSPERQVSSipiisggtkgllgtsllLDT 869
Cdd:COG5043  735 VEISILPKATNLPKIKVSGHMPHASLMFSDVQYKVIINLMSNI-LPTISVDEINGDYQQF-----------------SSA 796

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  870 VESESDDEYFDAEDGEPQTCKSmkgselkkAAEVPNEELINLLLkFEIKEVILEFTKQQKEEDTI-LVFNVTQLGTEATM 948
Cdd:COG5043  797 SLPPPFFDIKDNFQIENHANEQ--------TAAKFHAQQIFAFY-FKVDYFICSGLDSRSENYLVpVLRARLEFYFDLVA 867

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  949 RTFDLTVVSYLKKISLDYHEIEGSKRKPLHLISSSDKPGL--DLLKVEY--IKADKNGpsfqTAFGKTEQTVKVAFSSLN 1024
Cdd:COG5043  868 RKFNLRVTSNSNDIVDKEFTYPSSLCDNLLSRSSPKPKNNfdDTVFIEYksIDYDVLD----SVYEEVDTTIAVVLSDLI 943

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1025 LLLQTQALVASINYL--TTIIPSDDQSISVAKEVQISTeKQQKNSTLPKAIVS------SRDSDIIDFRLFAKLNAFCVI 1096
Cdd:COG5043  944 LNLEPTSFLTLIDFIrsTFTSPNDEYMIGEDPELTRKI-SDVENIKIEDANVRldnndiFLYDCIQLFATVLSYGAFMHM 1022

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1097 VCNEKNNIaEIKIQGLDsslslqsrkqslfaRLENIIVTDVDpktvhKKAVSIMGNEVFRFNLDLYpdategDLYTDMSK 1176
Cdd:COG5043 1023 EEREKFFL-QLRLMDLE--------------LKNHEKSNNPD-----STIVKIDDNKLFIFKYESY------DIPDPITD 1076

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1177 VDGVLSLNVGCiqivyLHK-FLMSLLNFLNNFQTAKESLSAATAQAAeraatSVKDLAQRSFRVSINIDLKAPVIVIPQs 1255
Cdd:COG5043 1077 CDCVLDISTGS-----LHFyFIESYFNFLSKFKRFKVSFSSIRYAAY-----YKAYGNKVSNNYKFELRIKHPIVQFPD- 1145

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1256 sistnavVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMdvqlTKLTLYRTVIQPGIYHPD-------IQLLHPINLEFLVN 1328
Cdd:COG5043 1146 -------VLGERNCRMQLIIKPGSFYAFSKCPVVEKN----SKLSIFSCELRKGEFSTAvpssghhDVLLEELNIHLDLT 1214

                       1370      1380      1390
                 ....*....|....*....|....*....|....*...
gi 66347845 1329 RNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRI 1366
Cdd:COG5043 1215 IDANPTTGENAYVFKATGDLDPVILNLCQSQHLILLDL 1252
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 3323-3500 1.23e-74

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


:

Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 246.69  E-value: 1.23e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   3323 SFFEHFHISPVKLHLSLSLGSGGEESDKEKQEmfavHSVNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVV 3402
Cdd:pfam16909    2 IYFELLHLQPIKLHLSFSRSERVNLEESLEKS----NPLSFLLNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNRIQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   3403 RHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRIT 3482
Cdd:pfam16909   78 KHYSQQFLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKIT 157

                          170
                   ....*....|....*...
gi 66347845   3483 GSVGKGLAAITMDKEYQQ 3500
Cdd:pfam16909  158 GSIGKGLAALTMDKQYQQ 175
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3184-3616 5.79e-49

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 194.72  E-value: 5.79e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 3184 LSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDsEPKPFIDVSVITRFNEYSKVLQFKYFMV 3263
Cdd:COG5043 2020 NVGIGLRFIDSKAYQTFSWECAWVQIDNQLVLGIYPVILYPTEISQEEKEI-ENHLLPSRKFAVVKDSDSAVTYDKYVTI 2098

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 3264 LIQEMALKIDQGFLGAIIALFTPttdPEAERRRTKLIQQDIdalnaELMETSMTDMSILSFFEHFHISPVKLHLSLSLGS 3343
Cdd:COG5043 2099 LLQELSIELDEDLALAYLEKLKF---PGSKYMDDKKFDDEI-----ELPDIIINKSGSNIYFEFLHLQPTRLHISFSRSS 2170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 3344 GGEESD-KEKQEMFA-VHSVNLLLKSIGatltdvddlifKLAYYEIRYQFYKRDQLIWS-------VVRHYSEQFLKQMY 3414
Cdd:COG5043 2171 ESSGEDgKVVPSSNSySDFYGMLAMTLG-----------NINDAPVRLNSLLMDNARVSlpelfdlIASHYLQQVEYQIY 2239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 3415 VLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQG--AVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAI 3492
Cdd:COG5043 2240 KILGSADFLGNPVGLFETVSSGVSDLFYEPYQGrfLVDNSQEWGIGIAKGGNSFIKKTIYGVSDSVSKFTGSISKGLSLV 2319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 3493 TMDKEYQQKRREELSR-QPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGIGKGLVGAVARPTGGIV 3571
Cdd:COG5043 2320 TSDPELQSSRRLVRRRnRPKGSVYGVTAGATSLYDSTSSGEKGLALEPIIGAATNGASGFVKGLGKGILGLETKPLVGFL 2399

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 66347845 3572 DMASSTFQGIQR--AAESTEEVSSLRPPRLIHEDGIIRPYDRQESEG 3616
Cdd:COG5043 2400 DLTSNDSEGIKNttTVLDYHDIPRLRLPRYVWDDGCVAPYDLRESQG 2446
SHR-BD super family cl05933
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2766-2942 4.71e-14

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


The actual alignment was detected with superfamily member pfam06650:

Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 75.42  E-value: 4.71e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   2766 LSVFSPYWLINKTTRVLQYRSEDIHVKHPADF------RDII--LFSFkKKNIFTKNKVQLKISTSAWSSSFSLDTVGSY 2837
Cdd:pfam06650    3 VSIYSPYVILNKTGLPLIVRSKGNKNKAAGTLesheggRRLIplMFSF-DTFDDRKNRALLRIGDSSWSKPFSFDAIGQT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   2838 GCVKCPANN--MEYLVGVSIKMSS--FNLSRIVTLTPFCTIANKSSLELevgEIASDGSmptNKWNYIASSECLPF-WPE 2912
Cdd:pfam06650   82 NDVVLPSPNgqNEVYLGISVSEGRgkYKLTKIVTIAPRFIIKNKLPEDL---EIREPGS---SKIISLPPGELIPLhWLR 155

                          170       180       190
                   ....*....|....*....|....*....|..
gi 66347845   2913 SLSGK-LCVRVVG-CEGSSKPFFYNrqDNGTL 2942
Cdd:pfam06650  156 NVEEKqLCIRFPGsNSQWSSPFNIS--DVGST 185
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
1046-2612 1.98e-13

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 77.62  E-value: 1.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1046 DDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSL 1125
Cdd:COG5043  435 EDTLASTDKTAAELTDQEQKDFFSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLISQRFENFKSKFSLNKLDL 514

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1126 FarleniivtDVDPKTVHKKAVSIMGNEVFR--FNLDLYPDATEGDLYTDM--SKVDGVLSLNVGC----IQIVYLHKFL 1197
Cdd:COG5043  515 F---------DGATNPELKPYRSIRNKPKVResESLQEIEEESRTHLFASFedSKPDGKASSTLIIhlrtLVIFYNRVCI 585

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1198 MSLLNFLNNFQTAKESLSAATAQAAEraatSVKDLAQRSF-----------RVSINIDLKAPVIVIPQSSISTNA--VVV 1264
Cdd:COG5043  586 LSVLKFFVPSRTKIEHVSEWVYSAAA----TVMTLTRQTRasldsalemhkTSNVTIDLQAPLIVFPEDCTDPKSptLFL 661

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1265 DLGLIRVHNQfsLVSDEDY--------LNPPVIDRM-----DVQLTKLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNL 1331
Cdd:COG5043  662 DAGRISIHSQ--LVEDAIIkkfrelqtLENLMYDRFtislfNVRCLIGPDYEGKRELPKGKCDYHILKELKLEINVEISI 739

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1332 AASWYhKVPVVEIKGHLDSMNVSLNQEDLNLLFRiLTENLCEGTEDLDKVKPRVQETGEIKEPLEIsisqdvhDSKNTLT 1411
Cdd:COG5043  740 LPKAT-NLPKIKVSGHMPHASLMFSDVQYKVIIN-LMSNILPTISVDEINGDYQQFSSASLPPPFF-------DIKDNFQ 810

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1412 TGVEEIRSVDIINMLLNFEIKEVVVTLMKKSEKKGRPLHEL-----NVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTD 1486
Cdd:COG5043  811 IENHANEQTAAKFHAQQIFAFYFKVDYFICSGLDSRSENYLvpvlrARLEFYFDLVARKFNLRVTSNSNDIVDKEFTYPS 890

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1487 SKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPfsepsss 1566
Cdd:COG5043  891 SLCDNLLSRSSPKPKNNFDDTVFIEYKSIDYDVLDSVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFT------- 963

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1567 ekeselkPLVGESRSIAVKAVSSNIsqKDVFDLKI-----TAELNAFNVFVCDQKCNIADIKIHGMDAS-ISVKPKQTDV 1640
Cdd:COG5043  964 -------SPNDEYMIGEDPELTRKI--SDVENIKIedanvRLDNNDIFLYDCIQLFATVLSYGAFMHMEeREKFFLQLRL 1034

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1641 FA--RLKDIIVMNVDlqsihKKAVSILGDEVFRFQLTLYpdategEAYADMSKVDGKLSFKVGCIqivyvHKFFM-SLLN 1717
Cdd:COG5043 1035 MDleLKNHEKSNNPD-----STIVKIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGSL-----HFYFIeSYFN 1098

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1718 FLNNFQTAKEalstaTVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNA---VIADLGLIRVENKFSLVP 1794
Cdd:COG5043 1099 FLSKFKRFKV-----SFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGERNCrmqLIIKPGSFYAFSKCPVVE 1173

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1795 MEHYslppvIDKMNIELTQLKLSRTILQASLPQNDIEILKpVNMLLSIQRNLAAAwyVQIPGMEIKGKLKPMQVALSEDD 1874
Cdd:COG5043 1174 KNSK-----LSIFSCELRKGEFSTAVPSSGHHDVLLEELN-IHLDLTIDANPTTG--ENAYVFKATGDLDPVILNLCQSQ 1245

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1875 LTVLMKIL-----LENLGEASSQPSPTQSVQETVRVRkvdvSSVPDHLKEqedwtdSKLSMNQIVSLQFDFHFESLSIIL 1949
Cdd:COG5043 1246 HLILLDLIdvvttFFRIDSSFSTSENLPRELDSEFDR----SGTPVKLKH------SKKTVVETLDILFTFKLPKIRLNL 1315

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1950 YNNDINQESGVAFHNDSFQLGELRLhlmasSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSsmID 2029
Cdd:COG5043 1316 YTGTFGIHGGDLTGLHNILFFEIGL-----DYGFYSSGTVYAEFSIASFRIEDVNPIKDVVFLDVIEYSTNTHNLL--VN 1388

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2030 ISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVRpnmTLKAMI 2109
Cdd:COG5043 1389 GCLEYDSQGRLLNLVLDIDKMFLNLDYLYSIWSIFVHWLRAYYSHLDYLVEQEYFNMGNPNQVACGEESYK---LYRITI 1465

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2110 TDPEVVFVASLTKADAPALtaSFQCNLSLSTSKLeqMMEASVRDLKVLACPflrEKRGKNITTVLQPCSL---FMEKCtw 2186
Cdd:COG5043 1466 VDTTLVFVRDASDMNSYAI--PFFFGQFLVTQQS--IFTVTANNMGIFACK---MSETANINQLLDDFGIrftISQHC-- 1536

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2187 asgKQNINIM----VKEFIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITE 2262
Cdd:COG5043 1537 ---SEKIQIIttldFDSLLLRISVNDFLLLQTILRRIYNFIYALYDKETTDEELEKRTKDGQLALNPDFLAASVPTAQPS 1613

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2263 SFKGIEHslIEENCGVVVESIQVTLECGLGHRtvPLLLAESK-FSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLIE 2341
Cdd:COG5043 1614 SVFGIRL--CSEEFLINVDGIRLILISDLHDL--PLLDINIKpFQVDLKDWSTELNANASLELFMNFFNFSRSHWEPVLE 1689

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2342 rvegkrQWNLRLDVKKNpvqdksllpgddfipEPQMAIHISSGNTMNITISKSCLnvfNNLAKGFSEGTASTFDYSLKDR 2421
Cdd:COG5043 1690 ------PWKVGVHISRN---------------DSKTAVHVFSREIADIVLTPRLI---ATLHFIFTKLISTPFPIERKCD 1745

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2422 APFTVKN----AVGVPIKVKPNCNlrvmgfpEKSDIFDVDAGQNLELEYASmVPSSQGNLSIlsRQESSFFTLTIVPHGY 2497
Cdd:COG5043 1746 APYRIVNytqtAVSVWAQFENAAD-------SVECVRHLPNNTSTPWKFEE-WRQMQDVVSQ--DQDRVYIGVHVSNSKY 1815

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2498 TEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGN-KVITLRSPLQIKNHFSIAFiiyKFVKNVKLLER---IGIA 2573
Cdd:COG5043 1816 ESLRHVRVNRVGEHLLLISYPRDELKHYMVVDVRLGEDNiKHITLRSPLLIINETQTEI---EVVFCDSDGIQrsqIYHI 1892

                       1610      1620      1630      1640
                 ....*....|....*....|....*....|....*....|
gi 66347845 2574 RPEEEFHVPLD-SYRCQLFIQPAGilEHQYKESTTYISWK 2612
Cdd:COG5043 1893 SPEESCSLPIEtAYLYSIRIRPVS--EDKFNWSSQAISWK 1930
 
Name Accession Description Interval E-value
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3-1366 3.85e-90

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 330.31  E-value: 3.85e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845    3 LESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLTLKIPWKNLYGEAVVAT 82
Cdd:COG5043    2 LEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   83 LEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEeaLQKAAEKGTHSgefiyglenfvykdikpgrkrkkhkkhfkk 162
Cdd:COG5043   82 IEDIYLLISPQAKNSLTREELPQSQQALKQRQLDSWE--ILRETLEESSS------------------------------ 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  163 pfkgldrskdKPKEAKKDTFVEKLATQVIKNVQVKITDIHIKYED-DVTDPKRPLSFGVTLGELSLLTANEHWTPCILNE 241
Cdd:COG5043  130 ----------SPNISRKQSFIESLITKLIDNIQIYIEDIHLRFEDnLSADLEGPYSFGLTLYSLRATSTDASWTEYFVST 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  242 ADKIIYKLIRLDSLSAYWnvnCSMSYQRSREQILDQLKNEILTSGNIPPNY-QYIFQPISASAKLYMNPYAESELktPKL 320
Cdd:COG5043  200 DSSCIHKLITLDYFSIYW---CEISPCITTEDIDSYLENFQPMIAEKSPAYnEYILKPVRGTAKVSINKLPTDEI--PRL 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  321 DCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVL-EVHIRRYtqMWSWSNIK 399
Cdd:COG5043  275 RGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFLKYRPKSTPKEKPLEWFKYIILVVLdSIHEKRY--HWTWKYFK 352

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  400 KHRQLLKSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVfniilarQQAQVEVIRSGQKLRKKSA--DTGEKRGGWFSGL 477
Cdd:COG5043  353 ERCEDRRAYMKIIRKKYLNEQLSADLSKELEKRELTYDL-------IKYRSRLFRSLAKRRNSIYlkPQTHKLQGWFSGL 425

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  478 WGKKESKkkdeeslipETIDDLMTPEEKDKLFTAIG----YSESTHNLTLPKQYVAHIMTLKLVSTSVTIRENKNIPEIL 553
Cdd:COG5043  426 WNGKPQA---------QDEDTLASTDKTAAELTDQEqkdfFSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLI 496

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  554 KIQIIGLGTQVS-QRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPV 632
Cdd:COG5043  497 SQRFENFKSKFSlNKLDLFDGATNPELKPYRSIRNKPKVRESESLQEIEEESRTHLFASFEDSKPDGKASSTLIIHLRTL 576

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  633 EVIYDAKTVNAVVEFFQS--NKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQtGFHHEK 710
Cdd:COG5043  577 VIFYNRVCILSVLKFFVPsrTKIEHVSEWVYSAAATVMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPE-DCTDPK 655

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  711 SDLLILDFGTFQLNSKDQGLQKT-TNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRfQHPSTMHILQPMDIHVE 789
Cdd:COG5043  656 SPTLFLDAGRISIHSQLVEDAIIkKFRELQTLENLMYDRFTISLFNVRCLIGPDYEGKRELP-KGKCDYHILKELKLEIN 734

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  790 LAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIpLPQKSSAQSPERQVSSipiisggtkgllgtsllLDT 869
Cdd:COG5043  735 VEISILPKATNLPKIKVSGHMPHASLMFSDVQYKVIINLMSNI-LPTISVDEINGDYQQF-----------------SSA 796

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  870 VESESDDEYFDAEDGEPQTCKSmkgselkkAAEVPNEELINLLLkFEIKEVILEFTKQQKEEDTI-LVFNVTQLGTEATM 948
Cdd:COG5043  797 SLPPPFFDIKDNFQIENHANEQ--------TAAKFHAQQIFAFY-FKVDYFICSGLDSRSENYLVpVLRARLEFYFDLVA 867

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  949 RTFDLTVVSYLKKISLDYHEIEGSKRKPLHLISSSDKPGL--DLLKVEY--IKADKNGpsfqTAFGKTEQTVKVAFSSLN 1024
Cdd:COG5043  868 RKFNLRVTSNSNDIVDKEFTYPSSLCDNLLSRSSPKPKNNfdDTVFIEYksIDYDVLD----SVYEEVDTTIAVVLSDLI 943

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1025 LLLQTQALVASINYL--TTIIPSDDQSISVAKEVQISTeKQQKNSTLPKAIVS------SRDSDIIDFRLFAKLNAFCVI 1096
Cdd:COG5043  944 LNLEPTSFLTLIDFIrsTFTSPNDEYMIGEDPELTRKI-SDVENIKIEDANVRldnndiFLYDCIQLFATVLSYGAFMHM 1022

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1097 VCNEKNNIaEIKIQGLDsslslqsrkqslfaRLENIIVTDVDpktvhKKAVSIMGNEVFRFNLDLYpdategDLYTDMSK 1176
Cdd:COG5043 1023 EEREKFFL-QLRLMDLE--------------LKNHEKSNNPD-----STIVKIDDNKLFIFKYESY------DIPDPITD 1076

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1177 VDGVLSLNVGCiqivyLHK-FLMSLLNFLNNFQTAKESLSAATAQAAeraatSVKDLAQRSFRVSINIDLKAPVIVIPQs 1255
Cdd:COG5043 1077 CDCVLDISTGS-----LHFyFIESYFNFLSKFKRFKVSFSSIRYAAY-----YKAYGNKVSNNYKFELRIKHPIVQFPD- 1145

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1256 sistnavVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMdvqlTKLTLYRTVIQPGIYHPD-------IQLLHPINLEFLVN 1328
Cdd:COG5043 1146 -------VLGERNCRMQLIIKPGSFYAFSKCPVVEKN----SKLSIFSCELRKGEFSTAvpssghhDVLLEELNIHLDLT 1214

                       1370      1380      1390
                 ....*....|....*....|....*....|....*...
gi 66347845 1329 RNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRI 1366
Cdd:COG5043 1215 IDANPTTGENAYVFKATGDLDPVILNLCQSQHLILLDL 1252
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 182-413 1.49e-89

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 291.86  E-value: 1.49e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845    182 FVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILNEADKIIYKLIRLDSLSAYWNV 261
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTSKIIHKLVELESLSVYWDT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845    262 NC---SMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPISASAKLYMNPYAESElKTPKLDCNIEIQNIAIELTKPQY 338
Cdd:pfam16908   81 DSeslELLGDLDLEELLEKFKSLIASKSNKPPDHQYILKPVSGSAKLTLNKKGETE-TIPKIDLDLEFDEIGLTLDDRQY 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66347845    339 LSMIDLLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVLEVHIRRYtQMWSWSNIKKHRQLLKSYKIAYK 413
Cdd:pfam16908  160 RDILSLLDSFHRFLRRQKYRKYRPKVSVKENPRAWWKYAINAVLEEIRERR-RKWSWDYIKKRRDDRKEYIELYK 233
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 3323-3500 1.23e-74

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 246.69  E-value: 1.23e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   3323 SFFEHFHISPVKLHLSLSLGSGGEESDKEKQEmfavHSVNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVV 3402
Cdd:pfam16909    2 IYFELLHLQPIKLHLSFSRSERVNLEESLEKS----NPLSFLLNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNRIQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   3403 RHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRIT 3482
Cdd:pfam16909   78 KHYSQQFLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKIT 157

                          170
                   ....*....|....*...
gi 66347845   3483 GSVGKGLAAITMDKEYQQ 3500
Cdd:pfam16909  158 GSIGKGLAALTMDKQYQQ 175
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3184-3616 5.79e-49

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 194.72  E-value: 5.79e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 3184 LSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDsEPKPFIDVSVITRFNEYSKVLQFKYFMV 3263
Cdd:COG5043 2020 NVGIGLRFIDSKAYQTFSWECAWVQIDNQLVLGIYPVILYPTEISQEEKEI-ENHLLPSRKFAVVKDSDSAVTYDKYVTI 2098

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 3264 LIQEMALKIDQGFLGAIIALFTPttdPEAERRRTKLIQQDIdalnaELMETSMTDMSILSFFEHFHISPVKLHLSLSLGS 3343
Cdd:COG5043 2099 LLQELSIELDEDLALAYLEKLKF---PGSKYMDDKKFDDEI-----ELPDIIINKSGSNIYFEFLHLQPTRLHISFSRSS 2170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 3344 GGEESD-KEKQEMFA-VHSVNLLLKSIGatltdvddlifKLAYYEIRYQFYKRDQLIWS-------VVRHYSEQFLKQMY 3414
Cdd:COG5043 2171 ESSGEDgKVVPSSNSySDFYGMLAMTLG-----------NINDAPVRLNSLLMDNARVSlpelfdlIASHYLQQVEYQIY 2239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 3415 VLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQG--AVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAI 3492
Cdd:COG5043 2240 KILGSADFLGNPVGLFETVSSGVSDLFYEPYQGrfLVDNSQEWGIGIAKGGNSFIKKTIYGVSDSVSKFTGSISKGLSLV 2319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 3493 TMDKEYQQKRREELSR-QPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGIGKGLVGAVARPTGGIV 3571
Cdd:COG5043 2320 TSDPELQSSRRLVRRRnRPKGSVYGVTAGATSLYDSTSSGEKGLALEPIIGAATNGASGFVKGLGKGILGLETKPLVGFL 2399

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 66347845 3572 DMASSTFQGIQR--AAESTEEVSSLRPPRLIHEDGIIRPYDRQESEG 3616
Cdd:COG5043 2400 DLTSNDSEGIKNttTVLDYHDIPRLRLPRYVWDDGCVAPYDLRESQG 2446
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2766-2942 4.71e-14

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 75.42  E-value: 4.71e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   2766 LSVFSPYWLINKTTRVLQYRSEDIHVKHPADF------RDII--LFSFkKKNIFTKNKVQLKISTSAWSSSFSLDTVGSY 2837
Cdd:pfam06650    3 VSIYSPYVILNKTGLPLIVRSKGNKNKAAGTLesheggRRLIplMFSF-DTFDDRKNRALLRIGDSSWSKPFSFDAIGQT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   2838 GCVKCPANN--MEYLVGVSIKMSS--FNLSRIVTLTPFCTIANKSSLELevgEIASDGSmptNKWNYIASSECLPF-WPE 2912
Cdd:pfam06650   82 NDVVLPSPNgqNEVYLGISVSEGRgkYKLTKIVTIAPRFIIKNKLPEDL---EIREPGS---SKIISLPPGELIPLhWLR 155

                          170       180       190
                   ....*....|....*....|....*....|..
gi 66347845   2913 SLSGK-LCVRVVG-CEGSSKPFFYNrqDNGTL 2942
Cdd:pfam06650  156 NVEEKqLCIRFPGsNSQWSSPFNIS--DVGST 185
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
1046-2612 1.98e-13

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 77.62  E-value: 1.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1046 DDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSL 1125
Cdd:COG5043  435 EDTLASTDKTAAELTDQEQKDFFSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLISQRFENFKSKFSLNKLDL 514

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1126 FarleniivtDVDPKTVHKKAVSIMGNEVFR--FNLDLYPDATEGDLYTDM--SKVDGVLSLNVGC----IQIVYLHKFL 1197
Cdd:COG5043  515 F---------DGATNPELKPYRSIRNKPKVResESLQEIEEESRTHLFASFedSKPDGKASSTLIIhlrtLVIFYNRVCI 585

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1198 MSLLNFLNNFQTAKESLSAATAQAAEraatSVKDLAQRSF-----------RVSINIDLKAPVIVIPQSSISTNA--VVV 1264
Cdd:COG5043  586 LSVLKFFVPSRTKIEHVSEWVYSAAA----TVMTLTRQTRasldsalemhkTSNVTIDLQAPLIVFPEDCTDPKSptLFL 661

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1265 DLGLIRVHNQfsLVSDEDY--------LNPPVIDRM-----DVQLTKLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNL 1331
Cdd:COG5043  662 DAGRISIHSQ--LVEDAIIkkfrelqtLENLMYDRFtislfNVRCLIGPDYEGKRELPKGKCDYHILKELKLEINVEISI 739

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1332 AASWYhKVPVVEIKGHLDSMNVSLNQEDLNLLFRiLTENLCEGTEDLDKVKPRVQETGEIKEPLEIsisqdvhDSKNTLT 1411
Cdd:COG5043  740 LPKAT-NLPKIKVSGHMPHASLMFSDVQYKVIIN-LMSNILPTISVDEINGDYQQFSSASLPPPFF-------DIKDNFQ 810

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1412 TGVEEIRSVDIINMLLNFEIKEVVVTLMKKSEKKGRPLHEL-----NVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTD 1486
Cdd:COG5043  811 IENHANEQTAAKFHAQQIFAFYFKVDYFICSGLDSRSENYLvpvlrARLEFYFDLVARKFNLRVTSNSNDIVDKEFTYPS 890

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1487 SKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPfsepsss 1566
Cdd:COG5043  891 SLCDNLLSRSSPKPKNNFDDTVFIEYKSIDYDVLDSVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFT------- 963

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1567 ekeselkPLVGESRSIAVKAVSSNIsqKDVFDLKI-----TAELNAFNVFVCDQKCNIADIKIHGMDAS-ISVKPKQTDV 1640
Cdd:COG5043  964 -------SPNDEYMIGEDPELTRKI--SDVENIKIedanvRLDNNDIFLYDCIQLFATVLSYGAFMHMEeREKFFLQLRL 1034

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1641 FA--RLKDIIVMNVDlqsihKKAVSILGDEVFRFQLTLYpdategEAYADMSKVDGKLSFKVGCIqivyvHKFFM-SLLN 1717
Cdd:COG5043 1035 MDleLKNHEKSNNPD-----STIVKIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGSL-----HFYFIeSYFN 1098

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1718 FLNNFQTAKEalstaTVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNA---VIADLGLIRVENKFSLVP 1794
Cdd:COG5043 1099 FLSKFKRFKV-----SFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGERNCrmqLIIKPGSFYAFSKCPVVE 1173

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1795 MEHYslppvIDKMNIELTQLKLSRTILQASLPQNDIEILKpVNMLLSIQRNLAAAwyVQIPGMEIKGKLKPMQVALSEDD 1874
Cdd:COG5043 1174 KNSK-----LSIFSCELRKGEFSTAVPSSGHHDVLLEELN-IHLDLTIDANPTTG--ENAYVFKATGDLDPVILNLCQSQ 1245

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1875 LTVLMKIL-----LENLGEASSQPSPTQSVQETVRVRkvdvSSVPDHLKEqedwtdSKLSMNQIVSLQFDFHFESLSIIL 1949
Cdd:COG5043 1246 HLILLDLIdvvttFFRIDSSFSTSENLPRELDSEFDR----SGTPVKLKH------SKKTVVETLDILFTFKLPKIRLNL 1315

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1950 YNNDINQESGVAFHNDSFQLGELRLhlmasSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSsmID 2029
Cdd:COG5043 1316 YTGTFGIHGGDLTGLHNILFFEIGL-----DYGFYSSGTVYAEFSIASFRIEDVNPIKDVVFLDVIEYSTNTHNLL--VN 1388

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2030 ISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVRpnmTLKAMI 2109
Cdd:COG5043 1389 GCLEYDSQGRLLNLVLDIDKMFLNLDYLYSIWSIFVHWLRAYYSHLDYLVEQEYFNMGNPNQVACGEESYK---LYRITI 1465

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2110 TDPEVVFVASLTKADAPALtaSFQCNLSLSTSKLeqMMEASVRDLKVLACPflrEKRGKNITTVLQPCSL---FMEKCtw 2186
Cdd:COG5043 1466 VDTTLVFVRDASDMNSYAI--PFFFGQFLVTQQS--IFTVTANNMGIFACK---MSETANINQLLDDFGIrftISQHC-- 1536

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2187 asgKQNINIM----VKEFIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITE 2262
Cdd:COG5043 1537 ---SEKIQIIttldFDSLLLRISVNDFLLLQTILRRIYNFIYALYDKETTDEELEKRTKDGQLALNPDFLAASVPTAQPS 1613

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2263 SFKGIEHslIEENCGVVVESIQVTLECGLGHRtvPLLLAESK-FSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLIE 2341
Cdd:COG5043 1614 SVFGIRL--CSEEFLINVDGIRLILISDLHDL--PLLDINIKpFQVDLKDWSTELNANASLELFMNFFNFSRSHWEPVLE 1689

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2342 rvegkrQWNLRLDVKKNpvqdksllpgddfipEPQMAIHISSGNTMNITISKSCLnvfNNLAKGFSEGTASTFDYSLKDR 2421
Cdd:COG5043 1690 ------PWKVGVHISRN---------------DSKTAVHVFSREIADIVLTPRLI---ATLHFIFTKLISTPFPIERKCD 1745

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2422 APFTVKN----AVGVPIKVKPNCNlrvmgfpEKSDIFDVDAGQNLELEYASmVPSSQGNLSIlsRQESSFFTLTIVPHGY 2497
Cdd:COG5043 1746 APYRIVNytqtAVSVWAQFENAAD-------SVECVRHLPNNTSTPWKFEE-WRQMQDVVSQ--DQDRVYIGVHVSNSKY 1815

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2498 TEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGN-KVITLRSPLQIKNHFSIAFiiyKFVKNVKLLER---IGIA 2573
Cdd:COG5043 1816 ESLRHVRVNRVGEHLLLISYPRDELKHYMVVDVRLGEDNiKHITLRSPLLIINETQTEI---EVVFCDSDGIQrsqIYHI 1892

                       1610      1620      1630      1640
                 ....*....|....*....|....*....|....*....|
gi 66347845 2574 RPEEEFHVPLD-SYRCQLFIQPAGilEHQYKESTTYISWK 2612
Cdd:COG5043 1893 SPEESCSLPIEtAYLYSIRIRPVS--EDKFNWSSQAISWK 1930
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 3507-3582 1.24e-10

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 60.60  E-value: 1.24e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66347845   3507 SRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQ 3582
Cdd:pfam09333    5 ANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVR 80
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 1690-1882 1.05e-06

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 52.90  E-value: 1.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   1690 SKVDGKLSFKVGCIQIVYVHKFFMSLLNFL---NNFQTAKEALSTATVQAAE----RAASSMKDLAQKSFRLLMDINLKA 1762
Cdd:pfam16910    8 GSADSRLTVKLRPLEIIYDPHFIEEVIDFFkppESHLELIGALMAAAEATLEgikeQTRAGLEYALEEHKTLDLDIDLQA 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   1763 PVIIIPQS--SVSPNAVIADLGLIRVENKfsLVPMEHYS--------------LPPVI----DKMNIEL--TQLKLSRTI 1820
Cdd:pfam16910   88 PLIIVPEDytSKDSPCLILDAGHISVTSD--LVDKSTIKeikskqsqqyteedLKELEslmyDKFSLKLsdTQVLIGPSG 165

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66347845   1821 --LQASLPQNDIE---ILKPVNMLLSIQRNLAAAwYVQIPGMEIKGKLKPMQVALSEDDLTVLMKIL 1882
Cdd:pfam16910  166 edWKEALTEDDSSplhILEPINLDLTLEKSILPK-APRLPKFKVSGHLPSLHINFSDDKYKSLMRLI 231
 
Name Accession Description Interval E-value
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3-1366 3.85e-90

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 330.31  E-value: 3.85e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845    3 LESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLTLKIPWKNLYGEAVVAT 82
Cdd:COG5043    2 LEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   83 LEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEeaLQKAAEKGTHSgefiyglenfvykdikpgrkrkkhkkhfkk 162
Cdd:COG5043   82 IEDIYLLISPQAKNSLTREELPQSQQALKQRQLDSWE--ILRETLEESSS------------------------------ 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  163 pfkgldrskdKPKEAKKDTFVEKLATQVIKNVQVKITDIHIKYED-DVTDPKRPLSFGVTLGELSLLTANEHWTPCILNE 241
Cdd:COG5043  130 ----------SPNISRKQSFIESLITKLIDNIQIYIEDIHLRFEDnLSADLEGPYSFGLTLYSLRATSTDASWTEYFVST 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  242 ADKIIYKLIRLDSLSAYWnvnCSMSYQRSREQILDQLKNEILTSGNIPPNY-QYIFQPISASAKLYMNPYAESELktPKL 320
Cdd:COG5043  200 DSSCIHKLITLDYFSIYW---CEISPCITTEDIDSYLENFQPMIAEKSPAYnEYILKPVRGTAKVSINKLPTDEI--PRL 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  321 DCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVL-EVHIRRYtqMWSWSNIK 399
Cdd:COG5043  275 RGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFLKYRPKSTPKEKPLEWFKYIILVVLdSIHEKRY--HWTWKYFK 352

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  400 KHRQLLKSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVfniilarQQAQVEVIRSGQKLRKKSA--DTGEKRGGWFSGL 477
Cdd:COG5043  353 ERCEDRRAYMKIIRKKYLNEQLSADLSKELEKRELTYDL-------IKYRSRLFRSLAKRRNSIYlkPQTHKLQGWFSGL 425

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  478 WGKKESKkkdeeslipETIDDLMTPEEKDKLFTAIG----YSESTHNLTLPKQYVAHIMTLKLVSTSVTIRENKNIPEIL 553
Cdd:COG5043  426 WNGKPQA---------QDEDTLASTDKTAAELTDQEqkdfFSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLI 496

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  554 KIQIIGLGTQVS-QRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPV 632
Cdd:COG5043  497 SQRFENFKSKFSlNKLDLFDGATNPELKPYRSIRNKPKVRESESLQEIEEESRTHLFASFEDSKPDGKASSTLIIHLRTL 576

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  633 EVIYDAKTVNAVVEFFQS--NKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQtGFHHEK 710
Cdd:COG5043  577 VIFYNRVCILSVLKFFVPsrTKIEHVSEWVYSAAATVMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPE-DCTDPK 655

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  711 SDLLILDFGTFQLNSKDQGLQKT-TNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRfQHPSTMHILQPMDIHVE 789
Cdd:COG5043  656 SPTLFLDAGRISIHSQLVEDAIIkKFRELQTLENLMYDRFTISLFNVRCLIGPDYEGKRELP-KGKCDYHILKELKLEIN 734

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  790 LAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIpLPQKSSAQSPERQVSSipiisggtkgllgtsllLDT 869
Cdd:COG5043  735 VEISILPKATNLPKIKVSGHMPHASLMFSDVQYKVIINLMSNI-LPTISVDEINGDYQQF-----------------SSA 796

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  870 VESESDDEYFDAEDGEPQTCKSmkgselkkAAEVPNEELINLLLkFEIKEVILEFTKQQKEEDTI-LVFNVTQLGTEATM 948
Cdd:COG5043  797 SLPPPFFDIKDNFQIENHANEQ--------TAAKFHAQQIFAFY-FKVDYFICSGLDSRSENYLVpVLRARLEFYFDLVA 867

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845  949 RTFDLTVVSYLKKISLDYHEIEGSKRKPLHLISSSDKPGL--DLLKVEY--IKADKNGpsfqTAFGKTEQTVKVAFSSLN 1024
Cdd:COG5043  868 RKFNLRVTSNSNDIVDKEFTYPSSLCDNLLSRSSPKPKNNfdDTVFIEYksIDYDVLD----SVYEEVDTTIAVVLSDLI 943

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1025 LLLQTQALVASINYL--TTIIPSDDQSISVAKEVQISTeKQQKNSTLPKAIVS------SRDSDIIDFRLFAKLNAFCVI 1096
Cdd:COG5043  944 LNLEPTSFLTLIDFIrsTFTSPNDEYMIGEDPELTRKI-SDVENIKIEDANVRldnndiFLYDCIQLFATVLSYGAFMHM 1022

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1097 VCNEKNNIaEIKIQGLDsslslqsrkqslfaRLENIIVTDVDpktvhKKAVSIMGNEVFRFNLDLYpdategDLYTDMSK 1176
Cdd:COG5043 1023 EEREKFFL-QLRLMDLE--------------LKNHEKSNNPD-----STIVKIDDNKLFIFKYESY------DIPDPITD 1076

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1177 VDGVLSLNVGCiqivyLHK-FLMSLLNFLNNFQTAKESLSAATAQAAeraatSVKDLAQRSFRVSINIDLKAPVIVIPQs 1255
Cdd:COG5043 1077 CDCVLDISTGS-----LHFyFIESYFNFLSKFKRFKVSFSSIRYAAY-----YKAYGNKVSNNYKFELRIKHPIVQFPD- 1145

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1256 sistnavVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMdvqlTKLTLYRTVIQPGIYHPD-------IQLLHPINLEFLVN 1328
Cdd:COG5043 1146 -------VLGERNCRMQLIIKPGSFYAFSKCPVVEKN----SKLSIFSCELRKGEFSTAvpssghhDVLLEELNIHLDLT 1214

                       1370      1380      1390
                 ....*....|....*....|....*....|....*...
gi 66347845 1329 RNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRI 1366
Cdd:COG5043 1215 IDANPTTGENAYVFKATGDLDPVILNLCQSQHLILLDL 1252
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 182-413 1.49e-89

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 291.86  E-value: 1.49e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845    182 FVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILNEADKIIYKLIRLDSLSAYWNV 261
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTSKIIHKLVELESLSVYWDT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845    262 NC---SMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPISASAKLYMNPYAESElKTPKLDCNIEIQNIAIELTKPQY 338
Cdd:pfam16908   81 DSeslELLGDLDLEELLEKFKSLIASKSNKPPDHQYILKPVSGSAKLTLNKKGETE-TIPKIDLDLEFDEIGLTLDDRQY 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66347845    339 LSMIDLLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVLEVHIRRYtQMWSWSNIKKHRQLLKSYKIAYK 413
Cdd:pfam16908  160 RDILSLLDSFHRFLRRQKYRKYRPKVSVKENPRAWWKYAINAVLEEIRERR-RKWSWDYIKKRRDDRKEYIELYK 233
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 612-833 2.28e-79

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 262.84  E-value: 2.28e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845    612 FETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLD--LEQITSATLMKLEEIKERTATGLTHIIETRKVLD 689
Cdd:pfam16910    1 FETNPLDGSADSRLTVKLRPLEIIYDPHFIEEVIDFFKPPESHLelIGALMAAAEATLEGIKEQTRAGLEYALEEHKTLD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845    690 LRINLKPSYLVVPQtGFHHEKSDLLILDFGTFQLNS-----------KDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQL 758
Cdd:pfam16910   81 LDIDLQAPLIIVPE-DYTSKDSPCLILDAGHISVTSdlvdkstikeiKSKQSQQYTEEDLKELESLMYDKFSLKLSDTQV 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66347845    759 LFARAEETWKKCRFQ-HPSTMHILQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLM-NSIP 833
Cdd:pfam16910  160 LIGPSGEDWKEALTEdDSSPLHILEPINLDLTLEKSILPKAPRLPKFKVSGHLPSLHINFSDDKYKSLMRLIdVSIP 236
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 3323-3500 1.23e-74

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 246.69  E-value: 1.23e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   3323 SFFEHFHISPVKLHLSLSLGSGGEESDKEKQEmfavHSVNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVV 3402
Cdd:pfam16909    2 IYFELLHLQPIKLHLSFSRSERVNLEESLEKS----NPLSFLLNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNRIQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   3403 RHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRIT 3482
Cdd:pfam16909   78 KHYSQQFLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKIT 157

                          170
                   ....*....|....*...
gi 66347845   3483 GSVGKGLAAITMDKEYQQ 3500
Cdd:pfam16909  158 GSIGKGLAALTMDKQYQQ 175
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3184-3616 5.79e-49

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 194.72  E-value: 5.79e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 3184 LSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDsEPKPFIDVSVITRFNEYSKVLQFKYFMV 3263
Cdd:COG5043 2020 NVGIGLRFIDSKAYQTFSWECAWVQIDNQLVLGIYPVILYPTEISQEEKEI-ENHLLPSRKFAVVKDSDSAVTYDKYVTI 2098

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 3264 LIQEMALKIDQGFLGAIIALFTPttdPEAERRRTKLIQQDIdalnaELMETSMTDMSILSFFEHFHISPVKLHLSLSLGS 3343
Cdd:COG5043 2099 LLQELSIELDEDLALAYLEKLKF---PGSKYMDDKKFDDEI-----ELPDIIINKSGSNIYFEFLHLQPTRLHISFSRSS 2170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 3344 GGEESD-KEKQEMFA-VHSVNLLLKSIGatltdvddlifKLAYYEIRYQFYKRDQLIWS-------VVRHYSEQFLKQMY 3414
Cdd:COG5043 2171 ESSGEDgKVVPSSNSySDFYGMLAMTLG-----------NINDAPVRLNSLLMDNARVSlpelfdlIASHYLQQVEYQIY 2239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 3415 VLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQG--AVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAI 3492
Cdd:COG5043 2240 KILGSADFLGNPVGLFETVSSGVSDLFYEPYQGrfLVDNSQEWGIGIAKGGNSFIKKTIYGVSDSVSKFTGSISKGLSLV 2319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 3493 TMDKEYQQKRREELSR-QPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGIGKGLVGAVARPTGGIV 3571
Cdd:COG5043 2320 TSDPELQSSRRLVRRRnRPKGSVYGVTAGATSLYDSTSSGEKGLALEPIIGAATNGASGFVKGLGKGILGLETKPLVGFL 2399

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 66347845 3572 DMASSTFQGIQR--AAESTEEVSSLRPPRLIHEDGIIRPYDRQESEG 3616
Cdd:COG5043 2400 DLTSNDSEGIKNttTVLDYHDIPRLRLPRYVWDDGCVAPYDLRESQG 2446
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 3-115 1.16e-41

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 150.02  E-value: 1.16e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845      3 LESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLTLKIPWKNLYGEAVVAT 82
Cdd:pfam12624    1 LESLVASLLNRYLGEYVENLDPDQLKVGLWSGDVVLENLKLKKEALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEPVVIE 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 66347845     83 LEGLYLLVVPGA-SIKYDAVKEEKSLQDVKQKEL 115
Cdd:pfam12624   81 IEDVYLLAVPKDeSEEYDEEEEEKRELAAKKEKL 114
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2766-2942 4.71e-14

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 75.42  E-value: 4.71e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   2766 LSVFSPYWLINKTTRVLQYRSEDIHVKHPADF------RDII--LFSFkKKNIFTKNKVQLKISTSAWSSSFSLDTVGSY 2837
Cdd:pfam06650    3 VSIYSPYVILNKTGLPLIVRSKGNKNKAAGTLesheggRRLIplMFSF-DTFDDRKNRALLRIGDSSWSKPFSFDAIGQT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   2838 GCVKCPANN--MEYLVGVSIKMSS--FNLSRIVTLTPFCTIANKSSLELevgEIASDGSmptNKWNYIASSECLPF-WPE 2912
Cdd:pfam06650   82 NDVVLPSPNgqNEVYLGISVSEGRgkYKLTKIVTIAPRFIIKNKLPEDL---EIREPGS---SKIISLPPGELIPLhWLR 155

                          170       180       190
                   ....*....|....*....|....*....|..
gi 66347845   2913 SLSGK-LCVRVVG-CEGSSKPFFYNrqDNGTL 2942
Cdd:pfam06650  156 NVEEKqLCIRFPGsNSQWSSPFNIS--DVGST 185
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
1046-2612 1.98e-13

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 77.62  E-value: 1.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1046 DDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSL 1125
Cdd:COG5043  435 EDTLASTDKTAAELTDQEQKDFFSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLISQRFENFKSKFSLNKLDL 514

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1126 FarleniivtDVDPKTVHKKAVSIMGNEVFR--FNLDLYPDATEGDLYTDM--SKVDGVLSLNVGC----IQIVYLHKFL 1197
Cdd:COG5043  515 F---------DGATNPELKPYRSIRNKPKVResESLQEIEEESRTHLFASFedSKPDGKASSTLIIhlrtLVIFYNRVCI 585

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1198 MSLLNFLNNFQTAKESLSAATAQAAEraatSVKDLAQRSF-----------RVSINIDLKAPVIVIPQSSISTNA--VVV 1264
Cdd:COG5043  586 LSVLKFFVPSRTKIEHVSEWVYSAAA----TVMTLTRQTRasldsalemhkTSNVTIDLQAPLIVFPEDCTDPKSptLFL 661

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1265 DLGLIRVHNQfsLVSDEDY--------LNPPVIDRM-----DVQLTKLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNL 1331
Cdd:COG5043  662 DAGRISIHSQ--LVEDAIIkkfrelqtLENLMYDRFtislfNVRCLIGPDYEGKRELPKGKCDYHILKELKLEINVEISI 739

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1332 AASWYhKVPVVEIKGHLDSMNVSLNQEDLNLLFRiLTENLCEGTEDLDKVKPRVQETGEIKEPLEIsisqdvhDSKNTLT 1411
Cdd:COG5043  740 LPKAT-NLPKIKVSGHMPHASLMFSDVQYKVIIN-LMSNILPTISVDEINGDYQQFSSASLPPPFF-------DIKDNFQ 810

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1412 TGVEEIRSVDIINMLLNFEIKEVVVTLMKKSEKKGRPLHEL-----NVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTD 1486
Cdd:COG5043  811 IENHANEQTAAKFHAQQIFAFYFKVDYFICSGLDSRSENYLvpvlrARLEFYFDLVARKFNLRVTSNSNDIVDKEFTYPS 890

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1487 SKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPfsepsss 1566
Cdd:COG5043  891 SLCDNLLSRSSPKPKNNFDDTVFIEYKSIDYDVLDSVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFT------- 963

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1567 ekeselkPLVGESRSIAVKAVSSNIsqKDVFDLKI-----TAELNAFNVFVCDQKCNIADIKIHGMDAS-ISVKPKQTDV 1640
Cdd:COG5043  964 -------SPNDEYMIGEDPELTRKI--SDVENIKIedanvRLDNNDIFLYDCIQLFATVLSYGAFMHMEeREKFFLQLRL 1034

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1641 FA--RLKDIIVMNVDlqsihKKAVSILGDEVFRFQLTLYpdategEAYADMSKVDGKLSFKVGCIqivyvHKFFM-SLLN 1717
Cdd:COG5043 1035 MDleLKNHEKSNNPD-----STIVKIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGSL-----HFYFIeSYFN 1098

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1718 FLNNFQTAKEalstaTVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNA---VIADLGLIRVENKFSLVP 1794
Cdd:COG5043 1099 FLSKFKRFKV-----SFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGERNCrmqLIIKPGSFYAFSKCPVVE 1173

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1795 MEHYslppvIDKMNIELTQLKLSRTILQASLPQNDIEILKpVNMLLSIQRNLAAAwyVQIPGMEIKGKLKPMQVALSEDD 1874
Cdd:COG5043 1174 KNSK-----LSIFSCELRKGEFSTAVPSSGHHDVLLEELN-IHLDLTIDANPTTG--ENAYVFKATGDLDPVILNLCQSQ 1245

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1875 LTVLMKIL-----LENLGEASSQPSPTQSVQETVRVRkvdvSSVPDHLKEqedwtdSKLSMNQIVSLQFDFHFESLSIIL 1949
Cdd:COG5043 1246 HLILLDLIdvvttFFRIDSSFSTSENLPRELDSEFDR----SGTPVKLKH------SKKTVVETLDILFTFKLPKIRLNL 1315

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 1950 YNNDINQESGVAFHNDSFQLGELRLhlmasSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSsmID 2029
Cdd:COG5043 1316 YTGTFGIHGGDLTGLHNILFFEIGL-----DYGFYSSGTVYAEFSIASFRIEDVNPIKDVVFLDVIEYSTNTHNLL--VN 1388

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2030 ISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVRpnmTLKAMI 2109
Cdd:COG5043 1389 GCLEYDSQGRLLNLVLDIDKMFLNLDYLYSIWSIFVHWLRAYYSHLDYLVEQEYFNMGNPNQVACGEESYK---LYRITI 1465

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2110 TDPEVVFVASLTKADAPALtaSFQCNLSLSTSKLeqMMEASVRDLKVLACPflrEKRGKNITTVLQPCSL---FMEKCtw 2186
Cdd:COG5043 1466 VDTTLVFVRDASDMNSYAI--PFFFGQFLVTQQS--IFTVTANNMGIFACK---MSETANINQLLDDFGIrftISQHC-- 1536

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2187 asgKQNINIM----VKEFIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITE 2262
Cdd:COG5043 1537 ---SEKIQIIttldFDSLLLRISVNDFLLLQTILRRIYNFIYALYDKETTDEELEKRTKDGQLALNPDFLAASVPTAQPS 1613

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2263 SFKGIEHslIEENCGVVVESIQVTLECGLGHRtvPLLLAESK-FSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLIE 2341
Cdd:COG5043 1614 SVFGIRL--CSEEFLINVDGIRLILISDLHDL--PLLDINIKpFQVDLKDWSTELNANASLELFMNFFNFSRSHWEPVLE 1689

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2342 rvegkrQWNLRLDVKKNpvqdksllpgddfipEPQMAIHISSGNTMNITISKSCLnvfNNLAKGFSEGTASTFDYSLKDR 2421
Cdd:COG5043 1690 ------PWKVGVHISRN---------------DSKTAVHVFSREIADIVLTPRLI---ATLHFIFTKLISTPFPIERKCD 1745

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2422 APFTVKN----AVGVPIKVKPNCNlrvmgfpEKSDIFDVDAGQNLELEYASmVPSSQGNLSIlsRQESSFFTLTIVPHGY 2497
Cdd:COG5043 1746 APYRIVNytqtAVSVWAQFENAAD-------SVECVRHLPNNTSTPWKFEE-WRQMQDVVSQ--DQDRVYIGVHVSNSKY 1815

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845 2498 TEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGN-KVITLRSPLQIKNHFSIAFiiyKFVKNVKLLER---IGIA 2573
Cdd:COG5043 1816 ESLRHVRVNRVGEHLLLISYPRDELKHYMVVDVRLGEDNiKHITLRSPLLIINETQTEI---EVVFCDSDGIQrsqIYHI 1892

                       1610      1620      1630      1640
                 ....*....|....*....|....*....|....*....|
gi 66347845 2574 RPEEEFHVPLD-SYRCQLFIQPAGilEHQYKESTTYISWK 2612
Cdd:COG5043 1893 SPEESCSLPIEtAYLYSIRIRPVS--EDKFNWSSQAISWK 1930
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 3507-3582 1.24e-10

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 60.60  E-value: 1.24e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66347845   3507 SRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQ 3582
Cdd:pfam09333    5 ANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVR 80
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 1690-1882 1.05e-06

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 52.90  E-value: 1.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   1690 SKVDGKLSFKVGCIQIVYVHKFFMSLLNFL---NNFQTAKEALSTATVQAAE----RAASSMKDLAQKSFRLLMDINLKA 1762
Cdd:pfam16910    8 GSADSRLTVKLRPLEIIYDPHFIEEVIDFFkppESHLELIGALMAAAEATLEgikeQTRAGLEYALEEHKTLDLDIDLQA 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   1763 PVIIIPQS--SVSPNAVIADLGLIRVENKfsLVPMEHYS--------------LPPVI----DKMNIEL--TQLKLSRTI 1820
Cdd:pfam16910   88 PLIIVPEDytSKDSPCLILDAGHISVTSD--LVDKSTIKeikskqsqqyteedLKELEslmyDKFSLKLsdTQVLIGPSG 165

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66347845   1821 --LQASLPQNDIE---ILKPVNMLLSIQRNLAAAwYVQIPGMEIKGKLKPMQVALSEDDLTVLMKIL 1882
Cdd:pfam16910  166 edWKEALTEDDSSplhILEPINLDLTLEKSILPK-APRLPKFKVSGHLPSLHINFSDDKYKSLMRLI 231
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 1175-1367 1.67e-05

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 49.05  E-value: 1.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   1175 SKVDGVLSLNVGCIQIVYLHKFLMSLLNFlnnFQTAKESLSAATAQAAERAATsVKDLAQRSF-----------RVSINI 1243
Cdd:pfam16910    8 GSADSRLTVKLRPLEIIYDPHFIEEVIDF---FKPPESHLELIGALMAAAEAT-LEGIKEQTRagleyaleehkTLDLDI 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66347845   1244 DLKAPVIVIPQS--SISTNAVVVDLGLIRVH--------------NQFSLVSDEDY--LNPPVIDRMDVQLTKLTLyrtV 1305
Cdd:pfam16910   84 DLQAPLIIVPEDytSKDSPCLILDAGHISVTsdlvdkstikeiksKQSQQYTEEDLkeLESLMYDKFSLKLSDTQV---L 160

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66347845   1306 IQPGI--------------YHpdiqLLHPINLEFLVNRNLAASwYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRIL 1367
Cdd:pfam16910  161 IGPSGedwkealteddsspLH----ILEPINLDLTLEKSILPK-APRLPKFKVSGHLPSLHINFSDDKYKSLMRLI 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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