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Conserved domains on  [gi|66346715|ref|NP_001018025|]
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protein p13 MTCP-1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TCL1_MTCP1 super family cl03378
TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell ...
 6-105 3.20e-30

TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. This family contains two repeated motifs that form a single globular domain.


The actual alignment was detected with superfamily member pfam01840:

Pssm-ID: 460358  Cd Length: 118  Bit Score: 104.01  E-value: 3.20e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346715     6 VGAPPDHLWVHQEGIYRDEYQRTWVAVVEE----------ETSfLRARVQQIQVPLGDAARPSHLLTSQLPLMWQLYPEE 75
Cdd:pfam01840  10 LPSPPDRLWIWRPGIYEDENGRTWLPVVVEtsgssrgwriETQ-VTVHLWQMDVPPGEPMSPSQLTPSELPLMWQLYPGN 88

                          90       100       110
                  ....*....|....*....|....*....|
gi 66346715    76 RYMDNNSRLWQIQHHLMVRGVQELLLKLLP 105
Cdd:pfam01840  89 RYRASDSRFWRIVDHIQIDGTEQLILELMP 118
 
Name Accession Description Interval E-value
TCL1_MTCP1 pfam01840
TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell ...
 6-105 3.20e-30

TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. This family contains two repeated motifs that form a single globular domain.


Pssm-ID: 460358  Cd Length: 118  Bit Score: 104.01  E-value: 3.20e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346715     6 VGAPPDHLWVHQEGIYRDEYQRTWVAVVEE----------ETSfLRARVQQIQVPLGDAARPSHLLTSQLPLMWQLYPEE 75
Cdd:pfam01840  10 LPSPPDRLWIWRPGIYEDENGRTWLPVVVEtsgssrgwriETQ-VTVHLWQMDVPPGEPMSPSQLTPSELPLMWQLYPGN 88

                          90       100       110
                  ....*....|....*....|....*....|
gi 66346715    76 RYMDNNSRLWQIQHHLMVRGVQELLLKLLP 105
Cdd:pfam01840  89 RYRASDSRFWRIVDHIQIDGTEQLILELMP 118
 
Name Accession Description Interval E-value
TCL1_MTCP1 pfam01840
TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell ...
 6-105 3.20e-30

TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. This family contains two repeated motifs that form a single globular domain.


Pssm-ID: 460358  Cd Length: 118  Bit Score: 104.01  E-value: 3.20e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346715     6 VGAPPDHLWVHQEGIYRDEYQRTWVAVVEE----------ETSfLRARVQQIQVPLGDAARPSHLLTSQLPLMWQLYPEE 75
Cdd:pfam01840  10 LPSPPDRLWIWRPGIYEDENGRTWLPVVVEtsgssrgwriETQ-VTVHLWQMDVPPGEPMSPSQLTPSELPLMWQLYPGN 88

                          90       100       110
                  ....*....|....*....|....*....|
gi 66346715    76 RYMDNNSRLWQIQHHLMVRGVQELLLKLLP 105
Cdd:pfam01840  89 RYRASDSRFWRIVDHIQIDGTEQLILELMP 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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