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Conserved domains on  [gi|62955535|ref|NP_001017781|]
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rho GTPase-activating protein 1 [Danio rerio]

Protein Classification

CRAL-TRIO domain-containing protein( domain architecture ID 10617207)

CRAL-TRIO domain-containing protein act as a lipid binding protein which may bind small lipophilic molecules such as retinal, inositol, and vitamin E

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 238-432 7.59e-115

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 334.31  E-value: 7.59e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 238 LPFQQFGVSLTTLKHRAADSEGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVNFSQLEDVHLAAV 317
Cdd:cd04404   1 LPTQQFGVSLQFLKEKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 318 ILKMFLRELPEPLLTYQLYNDIVNFHNVDIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVF 397
Cdd:cd04404  81 ILKTFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVF 160

                       170       180       190
                ....*....|....*....|....*....|....*
gi 62955535 398 GPNLLWAQDASMTLSAIGLINNFTRVLLDLHQDVF 432
Cdd:cd04404 161 GPNLLWAKDASMSLSAINPINTFTKFLLDHQDEIF 195
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 82-215 2.83e-27

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


:

Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 105.87  E-value: 2.83e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535    82 GRKVIVFNACRMP--PQHQLDHHKLLMYLKQTL-DKYVESDYTLIYFHHGLTSENKPSLSWLRDAYREFDRKYKKNIKAL 158
Cdd:pfam13716   1 GRPVLVFISKLLPsrPASLDDLDRLLFYLLKTLsEKLKGKPFVVVVDHTGVTSENFPSLSFLKKAYDLLPRAFKKNLKAV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535   159 YIVHPTMFIRTIL-ILFKPIISFKFGRKINYINYLSELEEIVKCDQLV--IPNrVREYDD 215
Cdd:pfam13716  81 YVVHPSTFLRTFLkTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLPteLPG-VLSYDE 139
 
Name Accession Description Interval E-value
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 238-432 7.59e-115

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 334.31  E-value: 7.59e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 238 LPFQQFGVSLTTLKHRAADSEGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVNFSQLEDVHLAAV 317
Cdd:cd04404   1 LPTQQFGVSLQFLKEKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 318 ILKMFLRELPEPLLTYQLYNDIVNFHNVDIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVF 397
Cdd:cd04404  81 ILKTFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVF 160

                       170       180       190
                ....*....|....*....|....*....|....*
gi 62955535 398 GPNLLWAQDASMTLSAIGLINNFTRVLLDLHQDVF 432
Cdd:cd04404 161 GPNLLWAKDASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 261-406 4.59e-49

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 163.87  E-value: 4.59e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535   261 PLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVN-FSQLEDVHLAAVILKMFLRELPEPLLTYQLYNDI 339
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDlDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62955535   340 VNFHNV-DIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGPNLLWAQD 406
Cdd:pfam00620  81 IEAAKLpDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 260-426 6.82e-47

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 158.97  E-value: 6.82e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535    260 IPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEE-VNFSQLEDVHLAAVILKMFLRELPEPLLTYQLYND 338
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDpDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYEE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535    339 IVNFHNVDIESQA-ERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGPNLLWAQDASM-TLSAIGL 416
Cdd:smart00324  83 FIEAAKLEDETERlRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVaSLKDIRH 162

                          170
                   ....*....|
gi 62955535    417 INNFTRVLLD 426
Cdd:smart00324 163 QNTVIEFLIE 172
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 82-215 2.83e-27

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 105.87  E-value: 2.83e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535    82 GRKVIVFNACRMP--PQHQLDHHKLLMYLKQTL-DKYVESDYTLIYFHHGLTSENKPSLSWLRDAYREFDRKYKKNIKAL 158
Cdd:pfam13716   1 GRPVLVFISKLLPsrPASLDDLDRLLFYLLKTLsEKLKGKPFVVVVDHTGVTSENFPSLSFLKKAYDLLPRAFKKNLKAV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535   159 YIVHPTMFIRTIL-ILFKPIISFKFGRKINYINYLSELEEIVKCDQLV--IPNrVREYDD 215
Cdd:pfam13716  81 YVVHPSTFLRTFLkTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLPteLPG-VLSYDE 139
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 61-207 4.52e-22

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 92.01  E-value: 4.52e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535  61 DDPFYDIARHQIVeVAGDDNFGRKVIVFNAcRMPPQHQLDHHKLLMYLKQTLDKYVESDYTLIYFHH------GLTSENK 134
Cdd:cd00170   1 LEELLELLGGIGY-LGGRDKEGRPVLVFRA-GWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVviidlkGFSLSNL 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62955535 135 PSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIRTILILFKPIISFKFGRKINYINY-LSELEEIVKCDQLVIP 207
Cdd:cd00170  79 SDLSLLKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSdLEELLEYIDPDQLPKE 152
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 66-204 1.61e-21

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 90.44  E-value: 1.61e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535     66 DIARHQIVEVAGDDNFGRKVIVFNACRMPPqHQLDHHKLLMYLKQTLDKYVES---DYTLIYFHHGLTSENKPS----LS 138
Cdd:smart00516   3 ELLKAYIPGGRGYDKDGRPVLIERAGRFDL-KSVTLEELLRYLVYVLEKILQEekkTGGIEGFTVIFDLKGLSMsnpdLS 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62955535    139 WLRDAYREFDRKYKKNIKALYIVHPTMFIRTILILFKPIISFKFGRKINYI--NYLSELEEIVKCDQL 204
Cdd:smart00516  82 VLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVgnDSKEELLEYIDKEQL 149
 
Name Accession Description Interval E-value
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 238-432 7.59e-115

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 334.31  E-value: 7.59e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 238 LPFQQFGVSLTTLKHRAADSEGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVNFSQLEDVHLAAV 317
Cdd:cd04404   1 LPTQQFGVSLQFLKEKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 318 ILKMFLRELPEPLLTYQLYNDIVNFHNVDIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVF 397
Cdd:cd04404  81 ILKTFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVF 160

                       170       180       190
                ....*....|....*....|....*....|....*
gi 62955535 398 GPNLLWAQDASMTLSAIGLINNFTRVLLDLHQDVF 432
Cdd:cd04404 161 GPNLLWAKDASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 261-426 1.18e-50

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 168.63  E-value: 1.18e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 261 PLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVNFSQLEDVHLAAVILKMFLRELPEPLLTYQLYNDIV 340
Cdd:cd00159   1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 341 NFHN-VDIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGPNLLWAQDASMTLSA-IGLIN 418
Cdd:cd00159  81 ELAKiEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDDELLEdIKKLN 160


                ....*...
gi 62955535 419 NFTRVLLD 426
Cdd:cd00159 161 EIVEFLIE 168
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 261-406 4.59e-49

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 163.87  E-value: 4.59e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535   261 PLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVN-FSQLEDVHLAAVILKMFLRELPEPLLTYQLYNDI 339
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDlDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62955535   340 VNFHNV-DIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGPNLLWAQD 406
Cdd:pfam00620  81 IEAAKLpDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 260-426 6.82e-47

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 158.97  E-value: 6.82e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535    260 IPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEE-VNFSQLEDVHLAAVILKMFLRELPEPLLTYQLYND 338
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDpDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYEE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535    339 IVNFHNVDIESQA-ERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGPNLLWAQDASM-TLSAIGL 416
Cdd:smart00324  83 FIEAAKLEDETERlRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVaSLKDIRH 162

                          170
                   ....*....|
gi 62955535    417 INNFTRVLLD 426
Cdd:smart00324 163 QNTVIEFLIE 172
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 241-404 1.41e-43

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 151.46  E-value: 1.41e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 241 QQFGVSLTtlKHRAADSEGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSG----EEVNFSQleDVHLAA 316
Cdd:cd04386   3 PVFGTPLE--EHLKRTGREIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtfslPLDEFYS--DPHAVA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 317 VILKMFLRELPEPLLTYQLYNDIVNFHNvdIESQAERIQNM---LMSLPDENYASLRFLVQFLAQVSAESEINKMTNANL 393
Cdd:cd04386  79 SALKSYLRELPDPLLTYNLYEDWVQAAN--KPDEDERLQAIwriLNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNI 156

                       170
                ....*....|.
gi 62955535 394 AVVFGPNLLWA 404
Cdd:cd04386 157 AIVLAPNLLWA 167
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 243-401 2.72e-39

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 139.52  E-value: 2.72e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLKHRAADSEGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVNFSQLEDVHLAAVILKMF 322
Cdd:cd04393   3 FGVPLQELQQAGQPENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLLRLF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 323 LRELPEPLLTYQLYNDIVN-FHNVDIESQAER-IQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGPN 400
Cdd:cd04393  83 LQELPEGLIPASLQIRLMQlYQDYNGEDEFGRkLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAAVFGPD 162


                .
gi 62955535 401 L 401
Cdd:cd04393 163 V 163
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 260-432 5.08e-33

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 123.32  E-value: 5.08e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 260 IPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVNFSQLEDVHLAAVILKMFLRELPEPLLTYQLYNDI 339
Cdd:cd04390  22 VPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASLLKLYLRELPEPVIPWAQYEDF 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 340 V---NFHNVDIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGPNLLWAQ--DASMTLSAI 414
Cdd:cd04390 102 LscaQLLSKDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNILRPKveDPATIMEGT 181

                       170
                ....*....|....*...
gi 62955535 415 GLINNFTRVLLDLHQDVF 432
Cdd:cd04390 182 PQIQQLMTVMISKHEPLF 199
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 243-408 9.45e-33

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 122.41  E-value: 9.45e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLkhraADSEGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVNFSQlEDVHLAAVILKMF 322
Cdd:cd04402   2 FGQPLSNI----CEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKA-EPVLLLASVLKDF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 323 LRELPEPLLTYQLYNDIVNfhNVDIESQAERI---QNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGP 399
Cdd:cd04402  77 LRNIPGSLLSSDLYEEWMS--ALDQENEEEKIaelQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAP 154


                ....*....
gi 62955535 400 NLLWAQDAS 408
Cdd:cd04402 155 SLLWPPASS 163
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 243-402 1.06e-32

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 122.11  E-value: 1.06e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLKHRAADSegIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVNF--SQLEDVHLAAVILK 320
Cdd:cd04403   1 FGCHLEALCQRENST--VPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLddSKWEDIHVITGALK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 321 MFLRELPEPLLTYQLYNDIVN-FHNVDIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGP 399
Cdd:cd04403  79 LFFRELPEPLFPYSLFNDFVAaIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGP 158


                ...
gi 62955535 400 NLL 402
Cdd:cd04403 159 TLL 161
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 243-408 5.72e-31

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 117.54  E-value: 5.72e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLkhrAADSEGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSG-EEVNfsqLED--VHLAAVIL 319
Cdd:cd04377   1 FGVSLSSL---TSEDRSVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDpDSVN---LEDypIHVITSVL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 320 KMFLRELPEPLLTYQLYNDIVNfhNVDIESQAERIQ---NMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVV 396
Cdd:cd04377  75 KQWLRELPEPLMTFELYENFLR--AMELEEKQERVRalySVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIV 152

                       170
                ....*....|..
gi 62955535 397 FGPNLLWAQDAS 408
Cdd:cd04377 153 FAPCILRCPDTA 164
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 243-432 1.94e-30

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 115.96  E-value: 1.94e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLKHRAADSegIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNS--------GEEVNFSqleDVHL 314
Cdd:cd04398   1 FGVPLEDLILREGDN--VPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKdplnvlliSPEDYES---DIHS 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 315 AAVILKMFLRELPEPLLTYQLYNDIVNFHNVDIESQ-AERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANL 393
Cdd:cd04398  76 VASLLKLFFRELPEPLLTKALSREFIEAAKIEDESRrRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNL 155

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 62955535 394 AVVFGPNLLwaQDASMTLSAIGLINNFTRVLLDLHQDVF 432
Cdd:cd04398 156 AIIWGPTLM--NAAPDNAADMSFQSRVIETLLDNAYQIF 192
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 243-402 2.99e-30

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 116.03  E-value: 2.99e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLKHRAADSEG-IPLVMRDTIGFLLENgLQTEGIFRRSANVSLVKDVKAKYNSGEEVNFSQLE-DVhlaAVILK 320
Cdd:cd04394   2 FGVPLHSLPHSTVPEYGnVPKFLVDACTFLLDH-LSTEGLFRKSGSVVRQKELKAKLEGGEACLSSALPcDV---AGLLK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 321 MFLRELPEPLLTYQLYNDIVNFHnvDIESQAERIQNMLMS---LPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVF 397
Cdd:cd04394  78 QFFRELPEPLLPYDLHEALLKAQ--ELPTDEERKSATLLLtclLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIF 155


                ....*
gi 62955535 398 GPNLL 402
Cdd:cd04394 156 APNLF 160
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 260-410 1.33e-27

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 108.64  E-value: 1.33e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 260 IPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSG-EEVNFS--QLEDVHLAAVILKMFLRELPEPLLTYQLY 336
Cdd:cd04395  18 VPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGgFDIDLQdpRWRDVNVVSSLLKSFFRKLPEPLFTNELY 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62955535 337 NDIVNFHNvdIESQAERI---QNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGPNLLWAQDASMT 410
Cdd:cd04395  98 PDFIEANR--IEDPVERLkelRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIVFGPTLVRTSDDNME 172
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 82-215 2.83e-27

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 105.87  E-value: 2.83e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535    82 GRKVIVFNACRMP--PQHQLDHHKLLMYLKQTL-DKYVESDYTLIYFHHGLTSENKPSLSWLRDAYREFDRKYKKNIKAL 158
Cdd:pfam13716   1 GRPVLVFISKLLPsrPASLDDLDRLLFYLLKTLsEKLKGKPFVVVVDHTGVTSENFPSLSFLKKAYDLLPRAFKKNLKAV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535   159 YIVHPTMFIRTIL-ILFKPIISFKFGRKINYINYLSELEEIVKCDQLV--IPNrVREYDD 215
Cdd:pfam13716  81 YVVHPSTFLRTFLkTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLPteLPG-VLSYDE 139
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 243-401 3.90e-27

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 107.82  E-value: 3.90e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLKHR---AADSEGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVK----DVKAKYNSGEeVNFSQLEdVHLA 315
Cdd:cd04391   2 FGVPLSTLLERdqkKVPGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKflcqELEAKFYEGT-FLWDQVK-QHDA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 316 AVILKMFLRELPEPLLTYQLYNDIVNFHNV-DIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLA 394
Cdd:cd04391  80 ASLLKLFIRELPQPLLTVEYLPAFYSVQGLpSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159


                ....*..
gi 62955535 395 VVFGPNL 401
Cdd:cd04391 160 MIMAPNL 166
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 243-417 1.57e-26

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 105.97  E-value: 1.57e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLKHRAADseGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLV-KDVKAKYNSGEEVNFSQLEDvHLAAVILKM 321
Cdd:cd04378   1 FGVDFSQVPRDFPD--EVPFIIKKCTSEIENRALGVQGIYRVSGSKARVeKLCQAFENGKDLVELSELSP-HDISSVLKL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 322 FLRELPEPLLTYQLYNDIVNF-----------HNVDIESQAERI----QNMLMSLPDENYASLRFLVQFLAQVSAESEIN 386
Cdd:cd04378  78 FLRQLPEPLILFRLYNDFIALakeiqrdteedKAPNTPIEVNRIirklKDLLRQLPASNYNTLQHLIAHLYRVAEQFEEN 157

                       170       180       190
                ....*....|....*....|....*....|.
gi 62955535 387 KMTNANLAVVFGPNLLWAQDASMTLSAIGLI 417
Cdd:cd04378 158 KMSPNNLGIVFGPTLIRPRPGDADVSLSSLV 188
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-402 2.65e-26

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 104.89  E-value: 2.65e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 242 QFGVSLTtlKHRAADSEGIPLVMRDTIGFLLENGLqTEGIFRRSANVSLVKDVKAKYNSGEE---VNFSQLEDVHLAAVI 318
Cdd:cd04384   2 VFGCDLT--EHLLNSGQDVPQVLKSCTEFIEKHGI-VDGIYRLSGIASNIQRLRHEFDSEQIpdlTKDVYIQDIHSVSSL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 319 LKMFLRELPEPLLTYQLYNDIVNFHNVD-IESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVF 397
Cdd:cd04384  79 CKLYFRELPNPLLTYQLYEKFSEAVSAAsDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVW 158


                ....*
gi 62955535 398 GPNLL 402
Cdd:cd04384 159 APNLL 163
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 243-414 1.27e-25

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 102.76  E-value: 1.27e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLkhrAADSEGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVnfSQLED--VHLAAVILK 320
Cdd:cd04407   1 FGVRVGSL---TSNKTSVPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPEN--VKLENypIHAITGLLK 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 321 MFLRELPEPLLTYQLYNDIVnfHNVDIESQAERIQ---NMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVF 397
Cdd:cd04407  76 QWLRELPEPLMTFAQYNDFL--RAVELPEKQEQLQaiyRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVF 153

                       170
                ....*....|....*..
gi 62955535 398 GPNLLWAQDASMTLSAI 414
Cdd:cd04407 154 APCLLRCPDSSDPLTSM 170
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 243-401 1.34e-25

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 102.82  E-value: 1.34e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTT---LKHRAADSEGIPLVMRDTIGFLLENG-LQTEGIFRRSANVSLVKDVKAKYNSGEEVNF---SQLEDVHLA 315
Cdd:cd04400   2 FGSPLEEaveLSSHKYNGRDLPSVVYRCIEYLDKNRaIYEEGIFRLSGSASVIKQLKERFNTEYDVDLfssSLYPDVHTV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 316 AVILKMFLRELPEPLLTYQLYNDI--VNFHNVDIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANL 393
Cdd:cd04400  82 AGLLKLYLRELPTLILGGELHNDFkrLVEENHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRNV 161


                ....*...
gi 62955535 394 AVVFGPNL 401
Cdd:cd04400 162 CIVFSPTL 169
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 243-410 1.91e-25

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 102.60  E-value: 1.91e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLKHraADSEGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYN-SGEEVNFSQ--LEDVHLAAVIL 319
Cdd:cd04372   1 YGCDLTTLVK--AHNTQRPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDrDGEKADISAtvYPDINVITGAL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 320 KMFLRELPEPLLTYQLYNDIVNfhNVDIESQAERIQNM---LMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVV 396
Cdd:cd04372  79 KLYFRDLPIPVITYDTYPKFID--AAKISNPDERLEAVheaLMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIV 156

                       170
                ....*....|....*
gi 62955535 397 FGPNLLWA-QDASMT 410
Cdd:cd04372 157 FGPTLMRPpEDSALT 171
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 260-432 1.36e-24

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 100.59  E-value: 1.36e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 260 IPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVNFSQLEDVHLAAVILKMFLRELPEPLLTYQLYNDI 339
Cdd:cd04376   9 VPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELYTAF 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 340 VNFHNVDIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEI-----------NKMTNANLAVVFGPNLLWAQ--- 405
Cdd:cd04376  89 IGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADsidedgqevsgNKMTSLNLATIFGPNLLHKQksg 168

                       170       180       190
                ....*....|....*....|....*....|..
gi 62955535 406 -----DASMTLSAIGLINNFTRVLLDLHQDVF 432
Cdd:cd04376 169 erefvQASLRIEESTAIINVVQTMIDNYEELF 200
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 257-427 1.70e-24

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 99.69  E-value: 1.70e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 257 SEGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSgEEVNFS------QLEDVhlaAVILKMFLRELPEPL 330
Cdd:cd04385  12 DNDIPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRK-DARSVQlregeyTVHDV---ADVLKRFLRDLPDPL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 331 LTYQLYNDIvnFHNVDIESQAERI---QNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGPNLLWAQDA 407
Cdd:cd04385  88 LTSELHAEW--IEAAELENKDERIaryKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQTDEH 165

                       170       180
                ....*....|....*....|
gi 62955535 408 SmtlsaIGLINNFTRVLLDL 427
Cdd:cd04385 166 S-----VGQTSHEVKVIEDL 180
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 243-401 5.86e-24

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 99.03  E-value: 5.86e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLKHRAADSegIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNS-GEEVNFsQLEDVHLAAVILKM 321
Cdd:cd04375   5 FGVPLLVNLQRTGQP--LPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESsTDNVNY-DGQQAYDVADMLKQ 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 322 FLRELPEPLLTYQLYNDIVN-FHNVDIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGPN 400
Cdd:cd04375  82 YFRDLPEPLLTNKLSETFIAiFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCLAPS 161


                .
gi 62955535 401 L 401
Cdd:cd04375 162 L 162
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 243-414 5.60e-23

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 96.03  E-value: 5.60e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLKHRAADseGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEE-VNFSQLEDvHLAAVILKM 321
Cdd:cd04409   1 FGADFAQVAKKSPD--GIPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDlVELSELSP-HDISNVLKL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 322 FLRELPEPLLTYQLYNDIVNF----HNVDIESQAER-------------------IQNMLMSLPDENYASLRFLVQFLAQ 378
Cdd:cd04409  78 YLRQLPEPLILFRLYNEFIGLakesQHVNETQEAKKnsdkkwpnmctelnrillkSKDLLRQLPAPNYNTLQFLIVHLHR 157

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 62955535 379 VSAESEINKMTNANLAVVFGPNLLWAQ--DASMTLSAI 414
Cdd:cd04409 158 VSEQAEENKMSASNLGIIFGPTLIRPRptDATVSLSSL 195
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 256-414 3.70e-22

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 93.61  E-value: 3.70e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 256 DSEGIPLVmRDTIGFLLENGLQTEGIFRRSANVSLVKDVKA-----KYNSGEEVNFSQLE-DVHLAAVILKMFLRELPEP 329
Cdd:cd04374  25 DDIGFKFV-RKCIEAVETRGINEQGLYRVVGVNSKVQKLLSlgldpKTSTPGDVDLDNSEwEIKTITSALKTYLRNLPEP 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 330 LLTYQLYNDIVN-FHNVDIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGPNLLWAQDAs 408
Cdd:cd04374 104 LMTYELHNDFINaAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQEE- 182


                ....*.
gi 62955535 409 mTLSAI 414
Cdd:cd04374 183 -TVAAI 187
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 243-402 4.20e-22

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 93.45  E-value: 4.20e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLKHRaaDSEGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVNFSQLEDVHLAAV--ILK 320
Cdd:cd04387   1 FGVKISTVTKR--ERSKVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNKDVSVMLSEMDVNAIagTLK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 321 MFLRELPEPLLTYQLYNDIVNFHNV-DIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGP 399
Cdd:cd04387  79 LYFRELPEPLFTDELYPNFAEGIALsDPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFGP 158


                ...
gi 62955535 400 NLL 402
Cdd:cd04387 159 TLL 161
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 61-207 4.52e-22

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 92.01  E-value: 4.52e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535  61 DDPFYDIARHQIVeVAGDDNFGRKVIVFNAcRMPPQHQLDHHKLLMYLKQTLDKYVESDYTLIYFHH------GLTSENK 134
Cdd:cd00170   1 LEELLELLGGIGY-LGGRDKEGRPVLVFRA-GWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVviidlkGFSLSNL 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62955535 135 PSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIRTILILFKPIISFKFGRKINYINY-LSELEEIVKCDQLVIP 207
Cdd:cd00170  79 SDLSLLKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSdLEELLEYIDPDQLPKE 152
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 243-409 9.49e-22

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 92.13  E-value: 9.49e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLkhraADSEG-IPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVNFSQLE-DVHLAAVILK 320
Cdd:cd04373   1 FGVPLANV----VTSEKpIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDfTVNAVAGALK 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 321 MFLRELPEPLLTYQLYNDIVNFHNV-DIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGP 399
Cdd:cd04373  77 SFFSELPDPLIPYSMHLELVEAAKInDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWP 156

                       170
                ....*....|
gi 62955535 400 NLLWAQDASM 409
Cdd:cd04373 157 TLMRPDFTSM 166
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 66-204 1.61e-21

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 90.44  E-value: 1.61e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535     66 DIARHQIVEVAGDDNFGRKVIVFNACRMPPqHQLDHHKLLMYLKQTLDKYVES---DYTLIYFHHGLTSENKPS----LS 138
Cdd:smart00516   3 ELLKAYIPGGRGYDKDGRPVLIERAGRFDL-KSVTLEELLRYLVYVLEKILQEekkTGGIEGFTVIFDLKGLSMsnpdLS 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62955535    139 WLRDAYREFDRKYKKNIKALYIVHPTMFIRTILILFKPIISFKFGRKINYI--NYLSELEEIVKCDQL 204
Cdd:smart00516  82 VLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVgnDSKEELLEYIDKEQL 149
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 243-407 1.72e-21

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 91.76  E-value: 1.72e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLKHRAADSEGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNS---GEEVNFSQLEDVHLAAVIL 319
Cdd:cd04379   1 FGVPLSRLVEREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERnsaAVELSEELYPDINVITGVL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 320 KMFLRELPEPLLTYQLYNDIVNFHNV----DIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAV 395
Cdd:cd04379  81 KDYLRELPEPLITPQLYEMVLEALAValpnDVQTNTHLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAV 160

                       170
                ....*....|..
gi 62955535 396 VFGPNLLWAQDA 407
Cdd:cd04379 161 CFGPVLMFCSQE 172
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 243-401 2.25e-21

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 90.96  E-value: 2.25e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLKHRAADSEGI--PLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVNFSQLEdVHLAAVILK 320
Cdd:cd04381   1 FGASLSLAVERSRCHDGIdlPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEYE-PPTVASLLK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 321 MFLRELPEPLLTYQLyndIVNFHNV----DIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVV 396
Cdd:cd04381  80 QYLRELPEPLLTKEL---MPRFEEAcgrpTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIV 156


                ....*
gi 62955535 397 FGPNL 401
Cdd:cd04381 157 LSPTV 161
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 243-402 4.62e-21

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 90.17  E-value: 4.62e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLKHraADSEGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEE--VNFSQLEDVHLAAVILK 320
Cdd:cd04383   3 FNGSLEEYIQ--DSGQAIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEDplADDQNDHDINSVAGVLK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 321 MFLRELPEPLLTYQLYNDIVNFhnVDIESQAERIQNM---LMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVF 397
Cdd:cd04383  81 LYFRGLENPLFPKERFEDLMSC--VKLENPTERVHQIreiLSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICF 158


                ....*
gi 62955535 398 GPNLL 402
Cdd:cd04383 159 GPTLM 163
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 239-402 1.60e-20

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 88.60  E-value: 1.60e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 239 PFQQFGVSLTTLKHRaadsegiplvmrdtigFLLENGLQTEGIFRRSANVSLVKDVKAKYNSGEeVNFSQLEDVHLAAVI 318
Cdd:cd04389  17 PELKLPWILTFLSEK----------------VLALGGFQTEGIFRVPGDIDEVNELKLRVDQWD-YPLSGLEDPHVPASL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 319 LKMFLRELPEPLLTYQLYNDIVNfhNVDIESQAERIQNmlmSLPDENYASLRFLVQFLAQVSAES--EINKMTNANLAVV 396
Cdd:cd04389  80 LKLWLRELEEPLIPDALYQQCIS--ASEDPDKAVEIVQ---KLPIINRLVLCYLINFLQVFAQPEnvAHTKMDVSNLAMV 154


                ....*.
gi 62955535 397 FGPNLL 402
Cdd:cd04389 155 FAPNIL 160
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 272-403 6.48e-20

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 87.52  E-value: 6.48e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 272 LENGLQTEGIFRRSANVSLVKDVKAKYNSGEEVNFSQLE-DVHLAAVILKMFLRELPEPLLTYQLYN------DIVNFHN 344
Cdd:cd04392  20 LEKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGfHAHDCATVLKGFLGELPEPLLTHAHYPahlqiaDLCQFDE 99

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62955535 345 -------VDIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGPNLLW 403
Cdd:cd04392 100 kgnktsaPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLIC 165
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 243-411 1.47e-19

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 86.65  E-value: 1.47e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTL-KHRAADSE--------GIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSG--EEVNFSQLED 311
Cdd:cd04397   1 FGVPLEILvEKFGADSTlgvgpgklRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNptEVPDLSKENP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 312 VHLAAvILKMFLRELPEPLLTYQLYNDIVNFHNVDIESQAERIQNMLMS-LPDENYASLRFLVQFLAQVSAESEI----- 385
Cdd:cd04397  81 VQLAA-LLKKFLRELPDPLLTFKLYRLWISSQKIEDEEERKRVLHLVYClLPKYHRDTMEVLFSFLKWVSSFSHIdeetg 159

                       170       180
                ....*....|....*....|....*.
gi 62955535 386 NKMTNANLAVVFGPNLLWAQDASMTL 411
Cdd:cd04397 160 SKMDIHNLATVITPNILYSKTDNPNT 185
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 243-410 3.93e-19

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 85.25  E-value: 3.93e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLKHRAADSegIPLVMRDTIGFLLENGLQTEGIFRRS-ANVSLVKDVKAKYNSGEEVNFSQLEDvHLAAVILKM 321
Cdd:cd04408   1 FGVDFSQLPRDFPEE--VPFVVVRCTAEIENRALGVQGIYRISgSKARVEKLCQAFENGRDLVDLSGHSP-HDITSVLKH 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 322 FLRELPEPLLTYQLYNDIVNF-------------HNVDIESQAERIQNMLMSLPDENYASLRFLVQFLAQVSAESEINKM 388
Cdd:cd04408  78 FLKELPEPVLPFQLYDDFIALakelqrdsekaaeSPSIVENIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKM 157

                       170       180
                ....*....|....*....|....*
gi 62955535 389 TNANLAVVFGPNLLW---AQDASMT 410
Cdd:cd04408 158 SPNNLGIVFGPTLLRplvGGDVSMI 182
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 243-421 1.65e-18

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 83.13  E-value: 1.65e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLkhrAADSEGIPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNSgeEVNFSQLED--VHLAAVILK 320
Cdd:cd04406   1 FGVELSRL---TSEDRSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDT--DANSVNLDDynIHVIASVFK 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 321 MFLRELPEPLLTYQLYNDIVNFHNVDIESQAER-IQNMLMSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGP 399
Cdd:cd04406  76 QWLRDLPNPLMTFELYEEFLRAMGLQERRETVRgVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAP 155

                       170       180
                ....*....|....*....|..
gi 62955535 400 NLLWAQDASMTLSAIGLINNFT 421
Cdd:cd04406 156 CILRCPDTTDPLQSVQDISKTT 177
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 243-409 4.22e-18

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 82.84  E-value: 4.22e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLT-TLKHRAA-----DSEG-------IPLVMRDTIGFLLENGLQTEGIFRRSANVSLVKDVKAKYNS----GEEVN 305
Cdd:cd04396   2 FGVSLEeSLKYASVaisivDEDGeqyvygyIPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTppdyGKSFD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 306 FSQLeDVHLAAVILKMFLRELPEPLLTYQLY----------NDIVNFH--------NVDIESQAERIQNMLMSLPDENYA 367
Cdd:cd04396  82 WDGY-TVHDAASVLRRYLNNLPEPLVPLDLYeefrnplrkrPRILQYMkgrineplNTDIDQAIKEYRDLITRLPNLNRQ 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 62955535 368 SLRFLVQFLAQVSAESEINKMTNANLAVVFGPNLLWAQDASM 409
Cdd:cd04396 161 LLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGILSHPDHEM 202
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 275-401 1.92e-16

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 77.33  E-value: 1.92e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 275 GLQTEGIFRRSANVSLVKDVKAKYNSGEEV-NFSQLeDVHLAAVILKMFLRELPEPLLTYQLYNDIVNFHNVDIE--SQA 351
Cdd:cd04382  32 GLTEEGLYRVSGSEREVKALKEKFLRGKTVpNLSKV-DIHVICGCLKDFLRSLKEPLITFALWKEFMEAAEILDEdnSRA 110

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62955535 352 ERIQNMLmSLPDENYASLRFLVQFLaQVSAESEINKMTNANLAVVFGPNL 401
Cdd:cd04382 111 ALYQAIS-ELPQPNRDTLAFLILHL-QRVAQSPECKMDINNLARVFGPTI 158
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 271-402 1.25e-11

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 63.90  E-value: 1.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 271 LLENGLQTEGIFRRSANVSLVKDVKAK----YNSGEEvnFSQLEDVHLAAVILKMFLRELPEPLLTYQLYNDIVNFHNVD 346
Cdd:cd04380  61 LYTRGLAQEGLFEEPGLPSEPGELLAEirdaLDTGSP--FNSPGSAESVAEALLLFLESLPDPIIPYSLYERLLEAVANN 138

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62955535 347 IESQAERIQNmlmSLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGPNLL 402
Cdd:cd04380 139 EEDKRQVIRI---SLPPVHRNVFVYLCSFLRELLSESADRGLDENTLATIFGRVLL 191
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 275-408 6.13e-07

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 49.87  E-value: 6.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 275 GLQTEGIFRRSANVSLVKDVKAKYNSGEEVNFSQLeDVHLAAVILKMFLRELPEPLLTYQLYNDIVNFHNvDIESQAERI 354
Cdd:cd04388  30 GLESSTLYRTQSSSSLTELRQILDCDAASVDLEQF-DVAALADALKRYLLDLPNPVIPAPVYSEMISRAQ-EVQSSDEYA 107

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 62955535 355 QNMLM-----SLPDENYASLRFLVQFLAQVSAESEINKMTNANLAVVFGPNLLWAQDAS 408
Cdd:cd04388 108 QLLRKlirspNLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALAEIFSPLLFRFQPAS 166
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 243-369 7.93e-03

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 37.70  E-value: 7.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955535 243 FGVSLTTLKHraADSEGIPLVMRDTIGFL------LENGLQTEGIFRRSANVSLVKDVKAKYNSG-----EEVNFSQLED 311
Cdd:cd04399   1 FGVDLETRCR--LDKKVVPLIVSAILSYLdqlypdLINDEVRRNVWTDPVSLKETHQLRNLLNKPkkpdkEVIILKKFEP 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62955535 312 VHLAAViLKMFLRELPEPLLTYQLYNDI----VNFHNVDIESQAERI---QNMLMSLPDENYASL 369
Cdd:cd04399  79 STVASV-LKLYLLELPDSLIPHDIYDLIrslySAYPPSQEDSDTARIqglQSTLSQLPKSHIATL 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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