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Conserved domains on  [gi|66346662|ref|NP_001017526|]
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rho GTPase-activating protein 8 isoform 1 [Homo sapiens]

Protein Classification

SEC14 and RhoGAP domain-containing protein( domain architecture ID 10617236)

SEC14 and RhoGAP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 222-412 2.56e-98

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04404:

Pssm-ID: 470621 [Multi-domain]  Cd Length: 195  Bit Score: 293.47  E-value: 2.56e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 222 QQFGVSLQYLKDKNQG-ELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILK 300
Cdd:cd04404   4 QQFGVSLQFLKEKNPEqEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILK 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 301 TFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLN 380
Cdd:cd04404  84 TFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPN 163

                       170       180       190
                ....*....|....*....|....*....|..
gi 66346662 381 LIWPSQGVSSLSALVPLNMFTELLIEYYEKIF 412
Cdd:cd04404 164 LLWAKDASMSLSAINPINTFTKFLLDHQDEIF 195
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 32-196 3.27e-23

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


:

Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 95.09  E-value: 3.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662    32 GRRVVTFSCCRMP--PSHELDHQRLLEYLKYTL-DQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKdgdltmwp 108
Cdd:pfam13716   1 GRPVLVFISKLLPsrPASLDDLDRLLFYLLKTLsEKLKGKPFVVVVDHTGVTSENFPSLSFLKKAYDLLPRA-------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662   109 rlvsnsklkrsshlslpkywdyrYKKNLKALYVVHPTSFIK-VLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVI 187
Cdd:pfam13716  73 -----------------------FKKNLKAVYVVHPSTFLRtFLKTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLPT 129

                         170
                  ....*....|
gi 66346662   188 P-PEVLRYDE 196
Cdd:pfam13716 130 ElPGVLSYDE 139
 
Name Accession Description Interval E-value
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 222-412 2.56e-98

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 293.47  E-value: 2.56e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 222 QQFGVSLQYLKDKNQG-ELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILK 300
Cdd:cd04404   4 QQFGVSLQFLKEKNPEqEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILK 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 301 TFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLN 380
Cdd:cd04404  84 TFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPN 163

                       170       180       190
                ....*....|....*....|....*....|..
gi 66346662 381 LIWPSQGVSSLSALVPLNMFTELLIEYYEKIF 412
Cdd:cd04404 164 LLWAKDASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 241-386 2.56e-49

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 165.41  E-value: 2.56e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662   241 PPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGK-PVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQI 319
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPdVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66346662   320 LGITCVES-SLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQ 386
Cdd:pfam00620  81 IEAAKLPDeEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 240-408 8.92e-46

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 157.04  E-value: 8.92e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662    240 IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYG-DIHIPAVILKTFLRELPQPLLTFQAYEQ 318
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEyDVHDVAGLLKLFLRELPEPLITYELYEE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662    319 ILGIT-CVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQG-VSSLSALVP 396
Cdd:smart00324  83 FIEAAkLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGeVASLKDIRH 162

                          170
                   ....*....|..
gi 66346662    397 LNMFTELLIEYY 408
Cdd:smart00324 163 QNTVIEFLIENA 174
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 32-196 3.27e-23

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 95.09  E-value: 3.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662    32 GRRVVTFSCCRMP--PSHELDHQRLLEYLKYTL-DQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKdgdltmwp 108
Cdd:pfam13716   1 GRPVLVFISKLLPsrPASLDDLDRLLFYLLKTLsEKLKGKPFVVVVDHTGVTSENFPSLSFLKKAYDLLPRA-------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662   109 rlvsnsklkrsshlslpkywdyrYKKNLKALYVVHPTSFIK-VLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVI 187
Cdd:pfam13716  73 -----------------------FKKNLKAVYVVHPSTFLRtFLKTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLPT 129

                         170
                  ....*....|
gi 66346662   188 P-PEVLRYDE 196
Cdd:pfam13716 130 ElPGVLSYDE 139
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 21-188 5.30e-22

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 92.01  E-value: 5.30e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662  21 GILQVAGDDRFGRRVVTFsCCRMPPSHELDHQRLLEYLKYTLDQYVENDYTIVYFHY------GLNSRNKPSLGWLQSAY 94
Cdd:cd00170  10 GIGYLGGRDKEGRPVLVF-RAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVviidlkGFSLSNLSDLSLLKKLL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662  95 KEFDRKdgdltmwprlvsnsklkrsshlslpkywdyrYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNY-L 173
Cdd:cd00170  89 KILQDH-------------------------------YPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSdL 137

                       170
                ....*....|....*
gi 66346662 174 SELHEHLKYDQLVIP 188
Cdd:cd00170 138 EELLEYIDPDQLPKE 152
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 16-196 1.17e-21

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 91.21  E-value: 1.17e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662     16 DVARHGILQVAGDDRFGRRVVTFSCCRMPPsHELDHQRLLEYLKYTLDQYVEN---DYTIVYFHYGLNSRNKPS----LG 88
Cdd:smart00516   3 ELLKAYIPGGRGYDKDGRPVLIERAGRFDL-KSVTLEELLRYLVYVLEKILQEekkTGGIEGFTVIFDLKGLSMsnpdLS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662     89 WLQSAYKEFDRkdgdltmwprlvsnsklkrsshlslpkywdyRYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKV- 167
Cdd:smart00516  82 VLRKILKILQD-------------------------------HYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIr 130

                          170       180       190
                   ....*....|....*....|....*....|
gi 66346662    168 -IYFNYLSELHEHLKYDQLviPPEVLRYDE 196
Cdd:smart00516 131 fVGNDSKEELLEYIDKEQL--PEELGGTLD 158
 
Name Accession Description Interval E-value
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 222-412 2.56e-98

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 293.47  E-value: 2.56e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 222 QQFGVSLQYLKDKNQG-ELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILK 300
Cdd:cd04404   4 QQFGVSLQFLKEKNPEqEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILK 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 301 TFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLN 380
Cdd:cd04404  84 TFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPN 163

                       170       180       190
                ....*....|....*....|....*....|..
gi 66346662 381 LIWPSQGVSSLSALVPLNMFTELLIEYYEKIF 412
Cdd:cd04404 164 LLWAKDASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 241-407 2.37e-49

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 166.32  E-value: 2.37e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 241 PPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQIL 320
Cdd:cd00159   1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 321 GITCVES-SLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVP-LN 398
Cdd:cd00159  81 ELAKIEDeEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDDELLEDIKkLN 160


                ....*....
gi 66346662 399 MFTELLIEY 407
Cdd:cd00159 161 EIVEFLIEN 169
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 241-386 2.56e-49

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 165.41  E-value: 2.56e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662   241 PPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGK-PVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQI 319
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPdVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66346662   320 LGITCVES-SLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQ 386
Cdd:pfam00620  81 IEAAKLPDeEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 240-408 8.92e-46

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 157.04  E-value: 8.92e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662    240 IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYG-DIHIPAVILKTFLRELPQPLLTFQAYEQ 318
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEyDVHDVAGLLKLFLRELPEPLITYELYEE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662    319 ILGIT-CVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQG-VSSLSALVP 396
Cdd:smart00324  83 FIEAAkLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGeVASLKDIRH 162

                          170
                   ....*....|..
gi 66346662    397 LNMFTELLIEYY 408
Cdd:smart00324 163 QNTVIEFLIENA 174
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 222-412 1.80e-36

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 133.35  E-value: 1.80e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 222 QQFGVSLQ-YLKdkNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQG--KPVNFDDYGDIHIPAVI 298
Cdd:cd04386   3 PVFGTPLEeHLK--RTGREIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtfSLPLDEFYSDPHAVASA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 299 LKTFLRELPQPLLTFQAYEQILGITCVESSL-RVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVF 377
Cdd:cd04386  81 LKSYLRELPDPLLTYNLYEDWVQAANKPDEDeRLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAIVL 160

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 66346662 378 GLNLIWP----SQGVSSLSALVPLNMFTELLIEYYEKIF 412
Cdd:cd04386 161 APNLLWAknegSLAEMAAGTSVHVVAIVELIISHADWFF 199
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 224-412 1.86e-32

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 122.02  E-value: 1.86e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQylKDKNQGELIPPVLRFtVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYgDIHIPAVILKTFL 303
Cdd:cd04402   2 FGQPLS--NICEDDNLPKPILDM-LSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAE-PVLLLASVLKDFL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 304 RELPQPLLTFQAYEQILGITCVESSL-RVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLI 382
Cdd:cd04402  78 RNIPGSLLSSDLYEEWMSALDQENEEeKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLL 157

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 66346662 383 WPS-------QGVSSLSALVplnmftELLIEYYEKIF 412
Cdd:cd04402 158 WPPasselqnEDLKKVTSLV------QFLIENCQEIF 188
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 224-406 3.45e-30

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 115.64  E-value: 3.45e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKNQ-GELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTF 302
Cdd:cd04393   3 FGVPLQELQQAGQpENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLLRLF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 303 LRELPQPLLT-------FQAYEQILGITCVESSLrvtgcRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLAC 375
Cdd:cd04393  83 LQELPEGLIPaslqirlMQLYQDYNGEDEFGRKL-----RDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAA 157

                       170       180       190
                ....*....|....*....|....*....|.
gi 66346662 376 VFGLNLIWPSQGVSSLSALVPLNMFTELLIE 406
Cdd:cd04393 158 VFGPDVFHVYTDVEDMKEQEICSRIMAKLLE 188
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 224-416 9.26e-27

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 106.79  E-value: 9.26e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKN--QGELIPPVLRFTVTYLrEKGLRTEGLFRRSASVQTVREIQRLYNQGKPVnFDDYGDIHIpAVILKT 301
Cdd:cd04394   2 FGVPLHSLPHSTvpEYGNVPKFLVDACTFL-LDHLSTEGLFRKSGSVVRQKELKAKLEGGEAC-LSSALPCDV-AGLLKQ 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 302 FLRELPQPLLTFQAYEQILGITCVESSlRVTGCRQILRS--LPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGL 379
Cdd:cd04394  79 FFRELPEPLLPYDLHEALLKAQELPTD-EERKSATLLLTclLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFAP 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 66346662 380 NLIWPSQGVSSLSALVP--LNMFT---ELLIEYYEKIFSTPE 416
Cdd:cd04394 158 NLFQSEEGGEKMSSSTEkrLRLQAavvQTLIDNASNIGIVPD 199
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 239-412 9.03e-26

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 104.06  E-value: 9.03e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 239 LIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQ 318
Cdd:cd04390  21 LVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASLLKLYLRELPEPVIPWAQYED 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 319 ILGITCVESSLRVTGCRQILR---SLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWP--SQGVSSLSA 393
Cdd:cd04390 101 FLSCAQLLSKDEEKGLGELMKqvsILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNILRPkvEDPATIMEG 180

                       170
                ....*....|....*....
gi 66346662 394 LVPLNMFTELLIEYYEKIF 412
Cdd:cd04390 181 TPQIQQLMTVMISKHEPLF 199
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 224-378 1.79e-25

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 102.90  E-value: 1.79e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKNQGelIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREI-QRLYNQGKPVNFDDYGdIHIPAVILKTF 302
Cdd:cd04377   1 FGVSLSSLTSEDRS--VPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELrQGLDTDPDSVNLEDYP-IHVITSVLKQW 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66346662 303 LRELPQPLLTFQAYEQILGITCV-ESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFG 378
Cdd:cd04377  78 LRELPEPLMTFELYENFLRAMELeEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFA 154
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 224-412 2.36e-24

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 99.79  E-value: 2.36e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKnQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQgKPVNFD-----DY-GDIHIPAV 297
Cdd:cd04398   1 FGVPLEDLILR-EGDNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDK-DPLNVLlispeDYeSDIHSVAS 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 298 ILKTFLRELPQPLLTFQAYEQIlgITCVES---SLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLA 374
Cdd:cd04398  79 LLKLFFRELPEPLLTKALSREF--IEAAKIedeSRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLA 156

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 66346662 375 CVFGLNLI-WPSQGVSSLSALVplnMFTELLIEYYEKIF 412
Cdd:cd04398 157 IIWGPTLMnAAPDNAADMSFQS---RVIETLLDNAYQIF 192
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 32-196 3.27e-23

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 95.09  E-value: 3.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662    32 GRRVVTFSCCRMP--PSHELDHQRLLEYLKYTL-DQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKdgdltmwp 108
Cdd:pfam13716   1 GRPVLVFISKLLPsrPASLDDLDRLLFYLLKTLsEKLKGKPFVVVVDHTGVTSENFPSLSFLKKAYDLLPRA-------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662   109 rlvsnsklkrsshlslpkywdyrYKKNLKALYVVHPTSFIK-VLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVI 187
Cdd:pfam13716  73 -----------------------FKKNLKAVYVVHPSTFLRtFLKTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLPT 129

                         170
                  ....*....|
gi 66346662   188 P-PEVLRYDE 196
Cdd:pfam13716 130 ElPGVLSYDE 139
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 224-406 4.35e-23

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 95.92  E-value: 4.35e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKnQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYG--DIHIPAVILKT 301
Cdd:cd04403   1 FGCHLEALCQR-ENSTVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLDDSKweDIHVITGALKL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 302 FLRELPQPLLTFQAYEQIL-GITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLN 380
Cdd:cd04403  80 FFRELPEPLFPYSLFNDFVaAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPT 159

                       170       180
                ....*....|....*....|....*..
gi 66346662 381 LIWPSQGVSSLSA-LVPLNMFTELLIE 406
Cdd:cd04403 160 LLRPEQETGNIAVhMVYQNQIVELILL 186
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 240-412 7.23e-23

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 95.66  E-value: 7.23e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 240 IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQ-GKPVNFDD--YGDIHIPAVILKTFLRELPQPLLTFQAY 316
Cdd:cd04372  16 RPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRdGEKADISAtvYPDINVITGALKLYFRDLPIPVITYDTY 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 317 EQ-ILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQgvssLSALV 395
Cdd:cd04372  96 PKfIDAAKISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPTLMRPPE----DSALT 171

                       170       180
                ....*....|....*....|...
gi 66346662 396 PLNMFT------ELLIEYYEKIF 412
Cdd:cd04372 172 TLNDMRyqilivQLLITNEDVLF 194
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 224-412 2.56e-22

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 94.39  E-value: 2.56e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGK---PVNFDDYGDIHIPAVILK 300
Cdd:cd04395   2 FGVPLDDCPPSSENPYVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGfdiDLQDPRWRDVNVVSSLLK 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 301 TFLRELPQPLLTFQAYEQILGITCVESSL-RVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGL 379
Cdd:cd04395  82 SFFRKLPEPLFTNELYPDFIEANRIEDPVeRLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIVFGP 161

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 66346662 380 NLIWPSQgvSSLSALVPlNM-----FTELLIEYYEKIF 412
Cdd:cd04395 162 TLVRTSD--DNMETMVT-HMpdqckIVETLIQHYDWFF 196
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 224-395 3.21e-22

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 94.03  E-value: 3.21e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKdKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSAS-VQTVREIQRLYNQGKPVNFDDYGDIHIPAViLKTF 302
Cdd:cd04378   1 FGVDFSQVP-RDFPDEVPFIIKKCTSEIENRALGVQGIYRVSGSkARVEKLCQAFENGKDLVELSELSPHDISSV-LKLF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 303 LRELPQPLLTFQAYEQILGI---------------TCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNK 367
Cdd:cd04378  79 LRQLPEPLILFRLYNDFIALakeiqrdteedkapnTPIEVNRIIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEENK 158

                       170       180       190
                ....*....|....*....|....*....|
gi 66346662 368 MNSSNLACVFGLNLIWPSQGVS--SLSALV 395
Cdd:cd04378 159 MSPNNLGIVFGPTLIRPRPGDAdvSLSSLV 188
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 224-376 3.81e-22

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 93.27  E-value: 3.81e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKNQ---GELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYgDIHIPAVILK 300
Cdd:cd04381   1 FGASLSLAVERSRchdGIDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEY-EPPTVASLLK 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66346662 301 TFLRELPQPLLT---FQAYEQILGITCVESslRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACV 376
Cdd:cd04381  80 QYLRELPEPLLTkelMPRFEEACGRPTEAE--REQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIV 156
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 21-188 5.30e-22

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 92.01  E-value: 5.30e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662  21 GILQVAGDDRFGRRVVTFsCCRMPPSHELDHQRLLEYLKYTLDQYVENDYTIVYFHY------GLNSRNKPSLGWLQSAY 94
Cdd:cd00170  10 GIGYLGGRDKEGRPVLVF-RAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVviidlkGFSLSNLSDLSLLKKLL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662  95 KEFDRKdgdltmwprlvsnsklkrsshlslpkywdyrYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNY-L 173
Cdd:cd00170  89 KILQDH-------------------------------YPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSdL 137

                       170
                ....*....|....*
gi 66346662 174 SELHEHLKYDQLVIP 188
Cdd:cd00170 138 EELLEYIDPDQLPKE 152
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 240-415 7.46e-22

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 93.27  E-value: 7.46e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 240 IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQI 319
Cdd:cd04376   9 VPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELYTAF 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 320 LGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRES-----------IFNKMNSSNLACVFGLNLIWPSQGV 388
Cdd:cd04376  89 IGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAadsidedgqevSGNKMTSLNLATIFGPNLLHKQKSG 168

                       170       180       190
                ....*....|....*....|....*....|....*
gi 66346662 389 SSLSALVPLNM--------FTELLIEYYEKIFSTP 415
Cdd:cd04376 169 EREFVQASLRIeestaiinVVQTMIDNYEELFMVS 203
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 16-196 1.17e-21

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 91.21  E-value: 1.17e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662     16 DVARHGILQVAGDDRFGRRVVTFSCCRMPPsHELDHQRLLEYLKYTLDQYVEN---DYTIVYFHYGLNSRNKPS----LG 88
Cdd:smart00516   3 ELLKAYIPGGRGYDKDGRPVLIERAGRFDL-KSVTLEELLRYLVYVLEKILQEekkTGGIEGFTVIFDLKGLSMsnpdLS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662     89 WLQSAYKEFDRkdgdltmwprlvsnsklkrsshlslpkywdyRYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKV- 167
Cdd:smart00516  82 VLRKILKILQD-------------------------------HYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIr 130

                          170       180       190
                   ....*....|....*....|....*....|
gi 66346662    168 -IYFNYLSELHEHLKYDQLviPPEVLRYDE 196
Cdd:smart00516 131 fVGNDSKEELLEYIDKEQL--PEELGGTLD 158
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 253-415 1.27e-21

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 92.52  E-value: 1.27e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 253 EKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYG-DIHIPAVILKTFLRELPQPLLT---FQAYEQILGITCVESS 328
Cdd:cd04392  21 EKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGfHAHDCATVLKGFLGELPEPLLThahYPAHLQIADLCQFDEK 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 329 LRVTGCRQ----------ILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSL--SALVP 396
Cdd:cd04392 101 GNKTSAPDkerllealqlLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRNLTPEDlhENAQK 180

                       170
                ....*....|....*....
gi 66346662 397 LNMFTELLIEYYEKIFSTP 415
Cdd:cd04392 181 LNSIVTFMIKHSQKLFKAP 199
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 224-382 2.02e-21

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 91.30  E-value: 2.02e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKnQGELIPPV-LRFTVTYLREK-----GLRTEGLFRRSASVQTVREIQRLYNQGKpVNFDDYGDIHIPAV 297
Cdd:cd04389   1 FGSSLEEIMDR-QKEKYPELkLPWILTFLSEKvlalgGFQTEGIFRVPGDIDEVNELKLRVDQWD-YPLSGLEDPHVPAS 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 298 ILKTFLRELPQPLLTFQAYEQilgitCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIF--NKMNSSNLAC 375
Cdd:cd04389  79 LLKLWLRELEEPLIPDALYQQ-----CISASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENVahTKMDVSNLAM 153


                ....*..
gi 66346662 376 VFGLNLI 382
Cdd:cd04389 154 VFAPNIL 160
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 224-414 2.06e-20

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 88.57  E-value: 2.06e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSL----QYLKDKNQGELIPPVLRFTVTYL-REKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNF---DDYGDIHIP 295
Cdd:cd04400   2 FGSPLeeavELSSHKYNGRDLPSVVYRCIEYLdKNRAIYEEGIFRLSGSASVIKQLKERFNTEYDVDLfssSLYPDVHTV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 296 AVILKTFLRELPQPLLTFQAYEQILGITCVESSL--RVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNL 373
Cdd:cd04400  82 AGLLKLYLRELPTLILGGELHNDFKRLVEENHDRsqRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRNV 161

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 66346662 374 ACVFG--LNliwpsqgvsslsalVPLNMFTELLIEyYEKIFST 414
Cdd:cd04400 162 CIVFSptLN--------------IPAGIFVLFLTD-FDCIFGG 189
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 225-382 4.08e-20

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 87.86  E-value: 4.08e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 225 GVSLQYLKDKNQgeLIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGK-PVNFDDYG-DIHIPAVILKTF 302
Cdd:cd04383   5 GSLEEYIQDSGQ--AIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEdPLADDQNDhDINSVAGVLKLY 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 303 LRELPQPLLTFQAYEQILGITCVESSL-RVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNL 381
Cdd:cd04383  83 FRGLENPLFPKERFEDLMSCVKLENPTeRVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGPTL 162


                .
gi 66346662 382 I 382
Cdd:cd04383 163 M 163
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 224-405 1.18e-19

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 86.58  E-value: 1.18e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYL-KDKNQgelIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQG-KPVNFDDYgDIHIPAVILKT 301
Cdd:cd04407   1 FGVRVGSLtSNKTS---VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADpENVKLENY-PIHAITGLLKQ 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 302 FLRELPQPLLTFQAYEQIL-GITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLN 380
Cdd:cd04407  77 WLRELPEPLMTFAQYNDFLrAVELPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAPC 156

                       170       180
                ....*....|....*....|....*...
gi 66346662 381 LIW---PSQGVSSLSALVPLNMFTELLI 405
Cdd:cd04407 157 LLRcpdSSDPLTSMKDVAKTTTCVEMLI 184
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 224-385 3.42e-18

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 82.12  E-value: 3.42e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKdKNQGElIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYG-DIHIPAVILKTF 302
Cdd:cd04373   1 FGVPLANVV-TSEKP-IPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDfTVNAVAGALKSF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 303 LRELPQPLLTF---QAYEQILGITcvESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFgl 379
Cdd:cd04373  79 FSELPDPLIPYsmhLELVEAAKIN--DREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICF-- 154


                ....*.
gi 66346662 380 nliWPS 385
Cdd:cd04373 155 ---WPT 157
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 224-415 8.42e-18

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 82.01  E-value: 8.42e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKNQ----GELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTV----REIQRLYNQGKpvnFD-DYGDIHI 294
Cdd:cd04391   2 FGVPLSTLLERDQkkvpGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVkflcQELEAKFYEGT---FLwDQVKQHD 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 295 PAVILKTFLRELPQPLLT---FQAYEQILGITCVESSLRVTGCRQILrsLPEHNYVVLRYLMGFLHAVSRESIFNKMNSS 371
Cdd:cd04391  79 AASLLKLFIRELPQPLLTveyLPAFYSVQGLPSKKDQLQALNLLVLL--LPEANRDTLKALLEFLQKVVDHEEKNKMNLW 156

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 66346662 372 NLACVFGLNLiWPSQGV---SSLSALVPLNM------FTELLIEYYEKIFSTP 415
Cdd:cd04391 157 NVAMIMAPNL-FPPRGKhskDNESLQEEVNMaagcanIMRLLIRYQDLLWTVP 208
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 224-378 1.43e-17

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 80.43  E-value: 1.43e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKNQGelIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREI-QRLYNQGKPVNFDDYgDIHIPAVILKTF 302
Cdd:cd04406   1 FGVELSRLTSEDRS--VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELrQGLDTDANSVNLDDY-NIHVIASVFKQW 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66346662 303 LRELPQPLLTFQAYEQIL-GITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFG 378
Cdd:cd04406  78 LRDLPNPLMTFELYEEFLrAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFA 154
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 234-407 1.79e-17

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 81.01  E-value: 1.79e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 234 KNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKP-VNFDDYGDIHIPAViLKTFLRELPQPLLT 312
Cdd:cd04409  10 KKSPDGIPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDlVELSELSPHDISNV-LKLYLRQLPEPLIL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 313 FQAYEQILGI-----------------------TCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMN 369
Cdd:cd04409  89 FRLYNEFIGLakesqhvnetqeakknsdkkwpnMCTELNRILLKSKDLLRQLPAPNYNTLQFLIVHLHRVSEQAEENKMS 168

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 66346662 370 SSNLACVFGLNLIWPSQGVS--SLSALVPLN---MFTELLIEY 407
Cdd:cd04409 169 ASNLGIIFGPTLIRPRPTDAtvSLSSLVDYPhqaRLVELLITY 211
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 224-386 7.84e-17

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 79.05  E-value: 7.84e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKNQGE-LIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQ---GKPVNFDDYGDIHIPAVIL 299
Cdd:cd04379   1 FGVPLSRLVEREGESrDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERnsaAVELSEELYPDINVITGVL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 300 KTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQ----ILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLAC 375
Cdd:cd04379  81 KDYLRELPEPLITPQLYEMVLEALAVALPNDVQTNTHltlsIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAV 160

                       170
                ....*....|.
gi 66346662 376 VFGLNLIWPSQ 386
Cdd:cd04379 161 CFGPVLMFCSQ 171
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 224-416 5.64e-16

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 76.63  E-value: 5.64e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKNQGEL----------IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQgKPVNFDDYGD-- 291
Cdd:cd04397   1 FGVPLEILVEKFGADStlgvgpgklrIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDK-NPTEVPDLSKen 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 292 -IHIpAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRvtgCRQILR----SLPEHNYVVLRYLMGFLHAVSR----- 361
Cdd:cd04397  80 pVQL-AALLKKFLRELPDPLLTFKLYRLWISSQKIEDEEE---RKRVLHlvycLLPKYHRDTMEVLFSFLKWVSSfshid 155

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 362 ESIFNKMNSSNLACVFGLNLIWPSQGVSSLSAlvplNMF-----TELLIEYYEKIFSTPE 416
Cdd:cd04397 156 EETGSKMDIHNLATVITPNILYSKTDNPNTGD----EYFlaieaVNYLIENNEEFCEVPD 211
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 240-411 2.19e-15

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 75.14  E-value: 2.19e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 240 IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQ----GKPVNFDDYgDIHIPAVILKTFLRELPQPLLTFQA 315
Cdd:cd04396  32 IPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTppdyGKSFDWDGY-TVHDAASVLRRYLNNLPEPLVPLDL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 316 YEQ----ILGITCVESSL--------------RVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVF 377
Cdd:cd04396 111 YEEfrnpLRKRPRILQYMkgrineplntdidqAIKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIF 190

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 66346662 378 GLNLIW-PSQGVSS----LSALVplnmfTELLIEYYEKI 411
Cdd:cd04396 191 QPGILShPDHEMDPkeykLSRLV-----VEFLIEHQDKF 224
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 224-393 2.82e-15

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 74.19  E-value: 2.82e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKdKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNqgkpVNFDDYG------DIHIPAV 297
Cdd:cd04387   1 FGVKISTVT-KRERSKVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFD----TNNKDVSvmlsemDVNAIAG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 298 ILKTFLRELPQPLLTFQAYEQIL-GITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACV 376
Cdd:cd04387  76 TLKLYFRELPEPLFTDELYPNFAeGIALSDPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATV 155

                       170
                ....*....|....*..
gi 66346662 377 FGLNLIWPSQGVSSLSA 393
Cdd:cd04387 156 FGPTLLRPSEKESKIPT 172
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 224-378 2.86e-15

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 73.87  E-value: 2.86e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVnfDDYGDIHIPAV--ILKT 301
Cdd:cd04382   1 IGTGELADFDPSTSPMIPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTV--PNLSKVDIHVIcgCLKD 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66346662 302 FLRELPQPLLTFQAYEQILGITCVESSLRV-TGCRQILRSLPEHNYVVLRYLMGFLHAVSrESIFNKMNSSNLACVFG 378
Cdd:cd04382  79 FLRSLKEPLITFALWKEFMEAAEILDEDNSrAALYQAISELPQPNRDTLAFLILHLQRVA-QSPECKMDINNLARVFG 155
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 224-395 3.09e-15

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 74.08  E-value: 3.09e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKNQGELIPPVLRFTVTyLREKGLRTEGLFRRSAS-VQTVREIQRLYNQGKPVNFDDYGDIHIPAViLKTF 302
Cdd:cd04408   1 FGVDFSQLPRDFPEEVPFVVVRCTAE-IENRALGVQGIYRISGSkARVEKLCQAFENGRDLVDLSGHSPHDITSV-LKHF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 303 LRELPQPLLTFQAYEQI--LGITCVESSLRVTGC-----------RQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMN 369
Cdd:cd04408  79 LKELPEPVLPFQLYDDFiaLAKELQRDSEKAAESpsiveniirslKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMS 158

                       170       180
                ....*....|....*....|....*..
gi 66346662 370 SSNLACVFGLNLIWPSQGVS-SLSALV 395
Cdd:cd04408 159 PNNLGIVFGPTLLRPLVGGDvSMICLL 185
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 224-382 8.70e-15

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 73.14  E-value: 8.70e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKNQGEL---IPPVLRFTVTYLREKGLRTEGLFR----RSASVQTVREIQRLYNQGKPVNFDdyGDIHIPA 296
Cdd:cd04380  31 LIDQLELGDNPDYSEVplsIPKEIWRLVDYLYTRGLAQEGLFEepglPSEPGELLAEIRDALDTGSPFNSP--GSAESVA 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 297 VILKTFLRELPQPLLTFQAYEQILgitcVESSLRVTGCRQILR-SLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLAC 375
Cdd:cd04380 109 EALLLFLESLPDPIIPYSLYERLL----EAVANNEEDKRQVIRiSLPPVHRNVFVYLCSFLRELLSESADRGLDENTLAT 184


                ....*..
gi 66346662 376 VFGLNLI 382
Cdd:cd04380 185 IFGRVLL 191
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 251-406 9.97e-15

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 72.81  E-value: 9.97e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 251 LREKGLRTEGLFRRSASVQTVreiQRLYNQGKPVNFDDYGDIHIP---------AVILKTFLRELPQPLLTFQAYEQILG 321
Cdd:cd04374  39 VETRGINEQGLYRVVGVNSKV---QKLLSLGLDPKTSTPGDVDLDnseweiktiTSALKTYLRNLPEPLMTYELHNDFIN 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 322 ITCVES-SLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQgvSSLSALVPL--- 397
Cdd:cd04374 116 AAKSENlESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQE--ETVAAIMDIkfq 193


                ....*....
gi 66346662 398 NMFTELLIE 406
Cdd:cd04374 194 NIVVEILIE 202
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 224-396 1.12e-14

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 72.84  E-value: 1.12e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 224 FGVSLQYLKDKNqGELIPPVLRFTVTYLREKGLRTEGLFRRS---ASVQTVREIQRLYNqgKPVNFDDYgDIHIPAVILK 300
Cdd:cd04375   5 FGVPLLVNLQRT-GQPLPRSIQQAMRWLRNNALDQVGLFRKSgvkSRIQKLRSMIESST--DNVNYDGQ-QAYDVADMLK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 301 TFLRELPQPLLTFQAYEQILGI-TCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGL 379
Cdd:cd04375  81 QYFRDLPEPLLTNKLSETFIAIfQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCLAP 160

                       170
                ....*....|....*..
gi 66346662 380 NLIWPSQgvSSLSALVP 396
Cdd:cd04375 161 SLFHLNT--SRRENSSP 175
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 235-386 1.28e-14

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 72.15  E-value: 1.28e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 235 NQGELIPPVLRFTVTYLREKGLrTEGLFRRSASVQTVREIQRLYNQGKP---VNFDDYGDIHIPAVILKTFLRELPQPLL 311
Cdd:cd04384  13 NSGQDVPQVLKSCTEFIEKHGI-VDGIYRLSGIASNIQRLRHEFDSEQIpdlTKDVYIQDIHSVSSLCKLYFRELPNPLL 91

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66346662 312 TFQAYEQIL-GITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQ 386
Cdd:cd04384  92 TYQLYEKFSeAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAPNLLRSKQ 167
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 240-378 1.11e-13

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 69.26  E-value: 1.11e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 240 IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQgKPVNFD-DYGDIHIPAV--ILKTFLRELPQPLLTFQAY 316
Cdd:cd04385  15 IPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRK-DARSVQlREGEYTVHDVadVLKRFLRDLPDPLLTSELH 93

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66346662 317 EQILGITCVE-SSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFG 378
Cdd:cd04385  94 AEWIEAAELEnKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFG 156
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 238-418 1.57e-09

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 57.58  E-value: 1.57e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 238 ELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYgDIHIPAVILKTFLRELPQPLLTFQAYE 317
Cdd:cd04388  13 DVAPPLLIKLVEAIEKKGLESSTLYRTQSSSSLTELRQILDCDAASVDLEQF-DVAALADALKRYLLDLPNPVIPAPVYS 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346662 318 QILGITCVESSLR--VTGCRQILRS--LPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGlNLIWPSQGVSSLSA 393
Cdd:cd04388  92 EMISRAQEVQSSDeyAQLLRKLIRSpnLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALAEIFS-PLLFRFQPASSDSP 170

                       170       180
                ....*....|....*....|....*
gi 66346662 394 LVPLNMFTELLIEYYEKIFSTPEAP 418
Cdd:cd04388 171 EFHIRIIEVLITSEWNERQAAPALP 195
CRAL_TRIO pfam00650
CRAL/TRIO domain;
136-192 1.38e-04

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 42.24  E-value: 1.38e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 66346662   136 LKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFN--YLSELHEHlkydqlvIPPEVL 192
Cdd:pfam00650  94 LGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKnsNEEELEKY-------IPPEQL 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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