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Conserved domains on  [gi|62945290|ref|NP_001017467|]
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lymphocyte antigen 6E precursor [Rattus norvegicus]

Protein Classification

Ly-6/uPAR domain-containing protein; Ly-6/uPAR domain-containing protein; acrosomal protein SP-10; acrosomal protein SP-10( domain architecture ID 10639047)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2); LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2); acrosomal protein SP-10 (ACRV1) is a testis-specific, intra-acrosomal protein that is associated with the membranes and matrix of the acrosomal vesicle; acrosomal protein SP-10 (ACRV1) is a testis-specific, intra-acrosomal protein that is associated with the membranes and matrix of the acrosomal vesicle

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 25-105 7.39e-29

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467073  Cd Length: 78  Bit Score: 100.51  E-value: 7.39e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945290  25 HSLMCFSCTDQKNNINCLWPVSCSSTDNYCITLSAAAGFGNvNLGYTLNKGCSPTCPRENINInlGVASVNSYCCQSSFC 104
Cdd:cd23543   1 HSLYCYTCENQSSNWNCLKPTKCSDNDKYCVTTVASGGTGS-SSGVRITKKCSPKCPETNVNI--GIASVSTSCCQSSLC 77


                .
gi 62945290 105 N 105
Cdd:cd23543  78 N 78
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 25-105 7.39e-29

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 100.51  E-value: 7.39e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945290  25 HSLMCFSCTDQKNNINCLWPVSCSSTDNYCITLSAAAGFGNvNLGYTLNKGCSPTCPRENINInlGVASVNSYCCQSSFC 104
Cdd:cd23543   1 HSLYCYTCENQSSNWNCLKPTKCSDNDKYCVTTVASGGTGS-SSGVRITKKCSPKCPETNVNI--GIASVSTSCCQSSLC 77


                .
gi 62945290 105 N 105
Cdd:cd23543  78 N 78
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 27-111 4.79e-18

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 72.95  E-value: 4.79e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945290     27 LMCFSCTDQkNNINCLWPVSCSSTDNYCITLSAAAGFGNVNLGYTLNKGCSPTCPRENIN-INLGVASVNSYCCQSSFCN 105
Cdd:smart00134   1 LQCYSCTGN-PDSSCSSEEECRSPDDVCLTVVAEVISDSRGSVVYKGCATSPICPGSHGYeINLTIAFLKVSCCQTDLCN 79


                   ....*.
gi 62945290    106 FSTAGL 111
Cdd:smart00134  80 AAGPGA 85
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 29-105 4.41e-14

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 62.56  E-value: 4.41e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62945290    29 CFSCTDQkNNINCLWPVSCSSTDNYCITLSAAAGFGNVNlGYTLNKGCS-PTCPR-ENININLGVASVNSYCCQSSFCN 105
Cdd:pfam00021   1 CYSCLGV-SNEDCLSEVTCPLSDGQCVTTTLELPEGNLR-GTVVSKGCArSSCPRlLSDFINGGIISVSESCCQSDLCN 77
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 25-105 7.39e-29

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 100.51  E-value: 7.39e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945290  25 HSLMCFSCTDQKNNINCLWPVSCSSTDNYCITLSAAAGFGNvNLGYTLNKGCSPTCPRENINInlGVASVNSYCCQSSFC 104
Cdd:cd23543   1 HSLYCYTCENQSSNWNCLKPTKCSDNDKYCVTTVASGGTGS-SSGVRITKKCSPKCPETNVNI--GIASVSTSCCQSSLC 77


                .
gi 62945290 105 N 105
Cdd:cd23543  78 N 78
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 27-111 4.79e-18

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 72.95  E-value: 4.79e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945290     27 LMCFSCTDQkNNINCLWPVSCSSTDNYCITLSAAAGFGNVNLGYTLNKGCSPTCPRENIN-INLGVASVNSYCCQSSFCN 105
Cdd:smart00134   1 LQCYSCTGN-PDSSCSSEEECRSPDDVCLTVVAEVISDSRGSVVYKGCATSPICPGSHGYeINLTIAFLKVSCCQTDLCN 79


                   ....*.
gi 62945290    106 FSTAGL 111
Cdd:smart00134  80 AAGPGA 85
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 25-109 6.00e-15

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 65.05  E-value: 6.00e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945290  25 HSLMCFSCTDQKNNINCLWPVSCSSTDNYCITLSAAAGFGNVNLGyTLNKGCSPTCPRENININLGVASVNsyCCQSSFC 104
Cdd:cd23575   1 HSLKCYTCVSAHSNSDCLTETNCSSSDTYCKTLVASASGGSGSLT-TITKWCASSCTPSTRTVEGTKVTVS--CCQTDLC 77


                ....*
gi 62945290 105 NFSTA 109
Cdd:cd23575  78 NVSGA 82
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 29-105 4.41e-14

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 62.56  E-value: 4.41e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62945290    29 CFSCTDQkNNINCLWPVSCSSTDNYCITLSAAAGFGNVNlGYTLNKGCS-PTCPR-ENININLGVASVNSYCCQSSFCN 105
Cdd:pfam00021   1 CYSCLGV-SNEDCLSEVTCPLSDGQCVTTTLELPEGNLR-GTVVSKGCArSSCPRlLSDFINGGIISVSESCCQSDLCN 77
TFP_LU_ECD_PSCA cd23573
extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; ...
 26-107 3.36e-06

extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467103  Cd Length: 78  Bit Score: 42.43  E-value: 3.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945290  26 SLMCFSCTDQKNNINCLWPVSCSSTDNYCIT-LSAAAGFGNVnlgytLNKGCSPTCprENININLGVASVNSYCCQSSFC 104
Cdd:cd23573   2 SLQCYTCKAQLSNSNCQTETPCRENAKACKTdVIRAVGLLKV-----ISKECSSSC--TEDYQDYFVGKRNITCCSTDLC 74


                ...
gi 62945290 105 NFS 107
Cdd:cd23573  75 NVN 77
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 23-105 4.91e-06

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 42.02  E-value: 4.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945290  23 QVHSLMCFSCTdqkNNINCLWPVSCSSTDNYCITLSAAAGFGNVnlgytLNKGCSPTCPRENININLGVASVNSYCCQSS 102
Cdd:cd23542   2 PANALQCHVCN---SSSNCTNPVNCEGSERYCKTTTVVQPSGNL-----VKKGCAETCPPSTSRQQVGSGISSVTCCQGD 73


                ...
gi 62945290 103 FCN 105
Cdd:cd23542  74 LCN 76
Toxin_TOLIP pfam00087
Snake toxin and toxin-like protein; This family predominantly includes venomous neurotoxins ...
 27-105 1.64e-04

Snake toxin and toxin-like protein; This family predominantly includes venomous neurotoxins and cytotoxins from snakes, but also structurally similar (non-snake) toxin-like proteins (TOLIPs) such as Lymphocyte antigen 6D and Ly6/PLAUR domain-containing protein. Snake toxins are short proteins with a compact, disulphide-rich structure. TOLIPs have similar structural features (abundance of spaced cysteine residues, a high frequency of charge residues, a signal peptide for secretion and a compact structure) but, are not associated with a venom gland or poisonous function. They are endogenous animal proteins that are not restricted to poisonous animals.


Pssm-ID: 395040  Cd Length: 70  Bit Score: 37.60  E-value: 1.64e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62945290    27 LMCFSCTdqkNNINCLWPVSCSSTDNYCITLSAaagfGNVNLGYTLNKGCSPTCPreNININLGVASVNSYCCQSSFCN 105
Cdd:pfam00087   1 LRCHNCA---AAGNCVQPETCQDNTRYCLTLWN----SPPGHRTHVIKGCAYTCP--VTQESLNISRASDCCCETDLCN 70
TFP_LU_ECD_CD59 cd23554
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ...
 27-105 9.92e-03

extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467084  Cd Length: 70  Bit Score: 32.68  E-value: 9.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945290  27 LMCFSCTDqkNNINCLWPVSCSSTDNYCITLSAAAGFgnvnlgytlNKGC--SPTCPRENININLGVASVNSYCCQSSFC 104
Cdd:cd23554   1 LKCYNCPN--PTSNCNTNVTCSSNLDACLIVKAGNRI---------YRQCwkYSDCNFDFISERFGESNFKYRCCQKDLC 69


                .
gi 62945290 105 N 105
Cdd:cd23554  70 N 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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