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Conserved domains on  [gi|831360240|ref|NP_001017360|]
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X-ray repair cross-complementing protein 5 [Danio rerio]

Protein Classification

ATP-dependent DNA helicase 2 subunit KU80( domain architecture ID 10208075)

ATP-dependent DNA helicase 2 subunit KU80 is part of a single-stranded DNA-dependent, ATP-dependent helicase involved in non-homologous end joining (NHEJ) DNA double strand break repair

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
KU80 cd00873
Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in ...
241-535 2.14e-115

Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the regulation of all the diverse functions of Ku is still unclear, although it seems that Ku is a multifunctional protein that works in nuclei. In mammalian cells, the Ku heterodimer recruits the catalytic subunit of DNA-dependent protein kinase (DNA-PK), which is dependent on its association with the Ku70/80 heterodimer bound to DNA for its protein kinase activity.


:

Pssm-ID: 238445 [Multi-domain]  Cd Length: 300  Bit Score: 349.67  E-value: 2.14e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 241 PMAWPCQLTIGSSLSIRIVGYKAVTEEKVKKSWTIVDAQSHQRD---DVKRETVYCLNDDDETEVQKDDTIQGYRYGSDI 317
Cdd:cd00873    1 VAAFKGQLTLGSPLSIAVELYKKTKEERPPKLKKVSDAEKTGEDafeDVKSERSYDVNDDDKTEVEKEDLIKGYRYGRDI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 318 VPFSKVDEEQMKYKHDgKCFSVLGFTKQELIPRHQFMGsQVVKVFAPRDDEHAAVALSSLIRALDGLKMAAIVRYAYDRR 397
Cdd:cd00873   81 VPLSEEDEEATKLSTS-KGLDILGFIKASNVPRYYLMG-ESSYVVPQQDDEAAALAFSALVRALAELDKYAIARYVYKDN 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 398 SNPQVGAAFPCIKKKYECLLYVQLPYMEDLRQFTFPMLENNK-KFMPSGSQLSAVDALIDSMMLMEKDENGeSVEIFKVN 476
Cdd:cd00873  159 SEPQLGVLFPRIKEDYECLVLVRLPFAEDVRQYRFPSLDKLKtPNLPTEEQLEAMDDLVDSMDLDDDEEDD-PEEALKPD 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 831360240 477 HIPNPQFQRLFQCLHHRGVNPDDPLPPVDPWLKRVLERPQAVSARCQAPLRDVKTSFPL 535
Cdd:cd00873  238 ETPNPVLQRIYQALRHRALHPDEPLPPLLQVLLRYLEPPEEVLEKSKEALKKIKEKFPL 296
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
6-231 4.17e-37

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member cd01458:

Pssm-ID: 469594  Cd Length: 218  Bit Score: 138.26  E-value: 4.17e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240   6 KSALVLCMDVGFSMSNSGPGQEP-PFEQAKKVIQKFVQRQVFAENKDEIGLVLFGTDGTKNPlandGQYENITVHRHLMI 84
Cdd:cd01458    1 KESVVFLVDVSPSMFESKDGEYEsPFEEALKCIRQLMKSKIISSPKDLVGVVFYGTEESKNP----VGYENIYVLLDLDT 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240  85 PDFEL----------LEEIERELQPGGQQADWLDALVVCMDLLQneTMGKKYDRLNIALLTDL-----NIQTSEDQLDII 149
Cdd:cd01458   77 PGAERvedlkeliepGGLSFAGQVGDSGQVSLSDALWVCLDLFS--KGKKKKSHKRIFLFTNNddphgGDSIKDSQAAVK 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 150 IQNLKKAGITLQFFlpfpvdvedeaggggdaagpsaPPSRPGKglsrqQTQGLEMVKHIMSSLED--EDGLEEVYTFSDA 227
Cdd:cd01458  155 AEDLKDKGIELELF----------------------PLSSPGK-----KFDVSKFYKDIIALVEDanEELLDEFTEPSKD 207

                 ....
gi 831360240 228 LEKL 231
Cdd:cd01458  208 LEDL 211
Ku_PK_bind pfam08785
Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by ...
588-701 3.17e-33

Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This domain is found at the C terminal of Ku which binds to DNA-PKcs.


:

Pssm-ID: 462604  Cd Length: 117  Bit Score: 123.85  E-value: 3.17e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240  588 NPARDFCTLIRQKTV--SFDQACQQLTHRIEQLLGNR-STEYYTKSIACIQAFRDQSVLSGNAELFNSYLQSLKRSIADR 664
Cdd:pfam08785   1 NPVPDFKQLLARGDDvdAVEKAVKQMGNIIEDLVRDSfGDSNYDKALECLRALREECIEEEEPDLYNDFLRDLKKKLLEG 80
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 831360240  665 SLQDFWNLLAQDALTLISKDEVEASTISKQEANQFLS 701
Cdd:pfam08785  81 DRREFWELVRKNKLGLITKDEAEDSDVTEEEAKEFLS 117
 
Name Accession Description Interval E-value
KU80 cd00873
Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in ...
241-535 2.14e-115

Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the regulation of all the diverse functions of Ku is still unclear, although it seems that Ku is a multifunctional protein that works in nuclei. In mammalian cells, the Ku heterodimer recruits the catalytic subunit of DNA-dependent protein kinase (DNA-PK), which is dependent on its association with the Ku70/80 heterodimer bound to DNA for its protein kinase activity.


Pssm-ID: 238445 [Multi-domain]  Cd Length: 300  Bit Score: 349.67  E-value: 2.14e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 241 PMAWPCQLTIGSSLSIRIVGYKAVTEEKVKKSWTIVDAQSHQRD---DVKRETVYCLNDDDETEVQKDDTIQGYRYGSDI 317
Cdd:cd00873    1 VAAFKGQLTLGSPLSIAVELYKKTKEERPPKLKKVSDAEKTGEDafeDVKSERSYDVNDDDKTEVEKEDLIKGYRYGRDI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 318 VPFSKVDEEQMKYKHDgKCFSVLGFTKQELIPRHQFMGsQVVKVFAPRDDEHAAVALSSLIRALDGLKMAAIVRYAYDRR 397
Cdd:cd00873   81 VPLSEEDEEATKLSTS-KGLDILGFIKASNVPRYYLMG-ESSYVVPQQDDEAAALAFSALVRALAELDKYAIARYVYKDN 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 398 SNPQVGAAFPCIKKKYECLLYVQLPYMEDLRQFTFPMLENNK-KFMPSGSQLSAVDALIDSMMLMEKDENGeSVEIFKVN 476
Cdd:cd00873  159 SEPQLGVLFPRIKEDYECLVLVRLPFAEDVRQYRFPSLDKLKtPNLPTEEQLEAMDDLVDSMDLDDDEEDD-PEEALKPD 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 831360240 477 HIPNPQFQRLFQCLHHRGVNPDDPLPPVDPWLKRVLERPQAVSARCQAPLRDVKTSFPL 535
Cdd:cd00873  238 ETPNPVLQRIYQALRHRALHPDEPLPPLLQVLLRYLEPPEEVLEKSKEALKKIKEKFPL 296
Ku pfam02735
Ku70/Ku80 beta-barrel domain; The Ku heterodimer (composed of Ku70 and Ku80) contributes to ...
250-450 1.36e-58

Ku70/Ku80 beta-barrel domain; The Ku heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the central DNA-binding beta-barrel domain. This domain is found in both the Ku70 and Ku80 proteins that form a DNA binding heterodimer.


Pssm-ID: 460669  Cd Length: 197  Bit Score: 196.70  E-value: 1.36e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240  250 IGSSLSIRIVGYKAVTEEKvKKSWTIVDAQSHqrDDVKRETVYClNDDDETEVQKDDTIQGYRYGSDIVPFSKVDEEQMK 329
Cdd:pfam02735   1 IGGLVSIPVKLYSATEEEK-KPSFKKLDRETN--DGVRIKYKYV-CEDTGKEVEKEDIVKGYEYGGTYVPLSDEELEELK 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240  330 YKHDgKCFSVLGFTKQELIPRHQFMGSQVVKVFAPRDDEHAAV-ALSSLIRALDGLKMAAIVRYAYDRRSNPQVGAAFPC 408
Cdd:pfam02735  77 PEST-KGLDLLGFVPLDEIDPIYFMGDKSYFLYPDKGDIAGSTkAFSALREALLETDKVAIARFVLRRREHPRLVALRPQ 155
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 831360240  409 IKKKYECLLYVQLPYMEDLRQFTFPMLENNKKFMPSGSQLSA 450
Cdd:pfam02735 156 EEEPDPGLVLITLPFADDVREEFFPIPSLLEKPKPTEEQLDL 197
Ku78 smart00559
Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen; This is a single ...
299-438 1.83e-42

Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen; This is a single stranded DNA- and ATP-depedent helicase that has a role in chromosome translocation. This is a domain of unknown function C-terminal to its von Willebrand factor A domain, that also occurs in bacterial hypothetical proteins.


Pssm-ID: 128831 [Multi-domain]  Cd Length: 140  Bit Score: 150.52  E-value: 1.83e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240   299 ETEVQKDDTIQGYRYGSDIVPFSKVDEEQMKYKHDgKCFSVLGFTKQELIPRHQFMGSQVVKVFAPRDDEHAAVALSSLI 378
Cdd:smart00559   1 GKEVKPEDIVKGYEYGGRYVPLSDEELEQLKYKSE-PGLELLGFKPLSSLPPYYFLRPSYFLVPDDKSVIGSTKAFSALV 79
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 831360240   379 RALDGLKMAAIVRYAYDRRSNPQVGAAFPCIKKKY-ECLLYVQLPYMEDLRQFTFPMLENN 438
Cdd:smart00559  80 EALLETDKIAIARYTLRTKSNPRLVALRPYDEEDDgEGLVLVQLPFADDVRKLDFPELNTT 140
vWA_ku cd01458
Ku70/Ku80 N-terminal domain. The Ku78 heterodimer (composed of Ku70 and Ku80) contributes to ...
6-231 4.17e-37

Ku70/Ku80 N-terminal domain. The Ku78 heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks (DSB) in a preferred orientation. DSB's are repaired by either homologues recombination or non-homologues end joining and facilitate repair by the non-homologous end-joining pathway (NHEJ). The Ku heterodimer is required for accurate process that tends to preserve the sequence at the junction. Ku78 is found in all three kingdoms of life. However, only the eukaryotic proteins have a vWA domain fused to them at their N-termini. The vWA domain is not involved in DNA binding but may very likey mediate Ku78's interactions with other proteins. Members of this subgroup lack the conserved MIDAS motif.


Pssm-ID: 238735  Cd Length: 218  Bit Score: 138.26  E-value: 4.17e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240   6 KSALVLCMDVGFSMSNSGPGQEP-PFEQAKKVIQKFVQRQVFAENKDEIGLVLFGTDGTKNPlandGQYENITVHRHLMI 84
Cdd:cd01458    1 KESVVFLVDVSPSMFESKDGEYEsPFEEALKCIRQLMKSKIISSPKDLVGVVFYGTEESKNP----VGYENIYVLLDLDT 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240  85 PDFEL----------LEEIERELQPGGQQADWLDALVVCMDLLQneTMGKKYDRLNIALLTDL-----NIQTSEDQLDII 149
Cdd:cd01458   77 PGAERvedlkeliepGGLSFAGQVGDSGQVSLSDALWVCLDLFS--KGKKKKSHKRIFLFTNNddphgGDSIKDSQAAVK 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 150 IQNLKKAGITLQFFlpfpvdvedeaggggdaagpsaPPSRPGKglsrqQTQGLEMVKHIMSSLED--EDGLEEVYTFSDA 227
Cdd:cd01458  155 AEDLKDKGIELELF----------------------PLSSPGK-----KFDVSKFYKDIIALVEDanEELLDEFTEPSKD 207

                 ....
gi 831360240 228 LEKL 231
Cdd:cd01458  208 LEDL 211
Ku_N pfam03731
Ku70/Ku80 N-terminal alpha/beta domain; The Ku heterodimer (composed of Ku70 and Ku80) ...
8-240 1.27e-36

Ku70/Ku80 N-terminal alpha/beta domain; The Ku heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the amino terminal alpha/beta domain. This domain only makes a small contribution to the dimer interface. The domain comprises a six stranded beta sheet of the Rossman fold.


Pssm-ID: 427470  Cd Length: 220  Bit Score: 137.11  E-value: 1.27e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240    8 ALVLCMDVGFSMSNSGPGQEPPFEQAKKVIQKFVQRQVFAENKDEIGLVLFGTDGTKnplaNDGQYENITVHRHLMIPDF 87
Cdd:pfam03731   1 AILFVIDVSPAMFESSKLLEAPFDMALKCIRELLKSKIISRDKDLIGVVLYGTDNSE----NSEGLPNITVLRDLDLPGA 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240   88 ----------ELLEEIERELQPGGQQADWLDALVVCMDLLQNetMGKKYDRLNIALLTDL-NIQTSEDQLDIIIQNLKKA 156
Cdd:pfam03731  77 elileldqfvESFGRDVRGFSGDSSDGSLLSALWVCLELLQK--TGKKLSHKRIFLFTDLdDPFEDQDKLDIALQRLLAE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240  157 GI--TLQFFLPFPVdvedeaggggdaagPSAPPSRPGKGLSRQQTQGLEMVKHIMSSLEDEDgleevytFSDALEKLSIF 234
Cdd:pfam03731 155 DLrdTRGEFDLIHL--------------PNADGFDPNLFYKDIIKLGSDEVLNVMLDLEGQK-------LEDLLAKIRAK 213

                  ....*.
gi 831360240  235 KRIERR 240
Cdd:pfam03731 214 KTAKRA 219
Ku_PK_bind pfam08785
Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by ...
588-701 3.17e-33

Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This domain is found at the C terminal of Ku which binds to DNA-PKcs.


Pssm-ID: 462604  Cd Length: 117  Bit Score: 123.85  E-value: 3.17e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240  588 NPARDFCTLIRQKTV--SFDQACQQLTHRIEQLLGNR-STEYYTKSIACIQAFRDQSVLSGNAELFNSYLQSLKRSIADR 664
Cdd:pfam08785   1 NPVPDFKQLLARGDDvdAVEKAVKQMGNIIEDLVRDSfGDSNYDKALECLRALREECIEEEEPDLYNDFLRDLKKKLLEG 80
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 831360240  665 SLQDFWNLLAQDALTLISKDEVEASTISKQEANQFLS 701
Cdd:pfam08785  81 DRREFWELVRKNKLGLITKDEAEDSDVTEEEAKEFLS 117
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
9-163 4.68e-07

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 50.53  E-value: 4.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240     9 LVLCMDVGFSMSNSgpgqepPFEQAKKVIQKFVQRQVFAENKDEIGLVLFGTDGTknPLANDGQYENITVHRHLMipdfe 88
Cdd:smart00327   2 VVFLLDGSGSMGGN------RFELAKEFVLKLVEQLDIGPDGDRVGLVTFSDDAR--VLFPLNDSRSKDALLEAL----- 68
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 831360240    89 lleeiERELQPGGQQADWLDALVVCMDLLQNETMGKKYDRLNIA-LLTDLNIQTSEDQLDIIIQNLKKAGITLQFF 163
Cdd:smart00327  69 -----ASLSYKLGGGTNLGAALQYALENLFSKSAGSRRGAPKVViLITDGESNDGPKDLLKAAKELKRSGVKVFVV 139
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
9-160 2.51e-04

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 43.39  E-value: 2.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240   9 LVLCMDVGFSMsnsgpGQEPPFEQAKKVIQKFVQRqvfAENKDEIGLVLFGTDG-TKNPLANDGQyeniTVHRHLMipdf 87
Cdd:COG1240   95 VVLVVDASGSM-----AAENRLEAAKGALLDFLDD---YRPRDRVGLVAFGGEAeVLLPLTRDRE----ALKRALD---- 158
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 831360240  88 elleeierELQPGGqQADWLDALVVCMDLLQNETMGKKydRLnIALLTDLNIQTSEDQLDIIIQNLKKAGITL 160
Cdd:COG1240  159 --------ELPPGG-GTPLGDALALALELLKRADPARR--KV-IVLLTDGRDNAGRIDPLEAAELAAAAGIRI 219
 
Name Accession Description Interval E-value
KU80 cd00873
Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in ...
241-535 2.14e-115

Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the regulation of all the diverse functions of Ku is still unclear, although it seems that Ku is a multifunctional protein that works in nuclei. In mammalian cells, the Ku heterodimer recruits the catalytic subunit of DNA-dependent protein kinase (DNA-PK), which is dependent on its association with the Ku70/80 heterodimer bound to DNA for its protein kinase activity.


Pssm-ID: 238445 [Multi-domain]  Cd Length: 300  Bit Score: 349.67  E-value: 2.14e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 241 PMAWPCQLTIGSSLSIRIVGYKAVTEEKVKKSWTIVDAQSHQRD---DVKRETVYCLNDDDETEVQKDDTIQGYRYGSDI 317
Cdd:cd00873    1 VAAFKGQLTLGSPLSIAVELYKKTKEERPPKLKKVSDAEKTGEDafeDVKSERSYDVNDDDKTEVEKEDLIKGYRYGRDI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 318 VPFSKVDEEQMKYKHDgKCFSVLGFTKQELIPRHQFMGsQVVKVFAPRDDEHAAVALSSLIRALDGLKMAAIVRYAYDRR 397
Cdd:cd00873   81 VPLSEEDEEATKLSTS-KGLDILGFIKASNVPRYYLMG-ESSYVVPQQDDEAAALAFSALVRALAELDKYAIARYVYKDN 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 398 SNPQVGAAFPCIKKKYECLLYVQLPYMEDLRQFTFPMLENNK-KFMPSGSQLSAVDALIDSMMLMEKDENGeSVEIFKVN 476
Cdd:cd00873  159 SEPQLGVLFPRIKEDYECLVLVRLPFAEDVRQYRFPSLDKLKtPNLPTEEQLEAMDDLVDSMDLDDDEEDD-PEEALKPD 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 831360240 477 HIPNPQFQRLFQCLHHRGVNPDDPLPPVDPWLKRVLERPQAVSARCQAPLRDVKTSFPL 535
Cdd:cd00873  238 ETPNPVLQRIYQALRHRALHPDEPLPPLLQVLLRYLEPPEEVLEKSKEALKKIKEKFPL 296
KU cd00594
Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the ...
243-533 7.22e-71

Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen recognized by the sera of patients with an autoimmunity disease. In eukaryotes, the Ku heterodimer contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by non-homologous end-joining. The bacterial Ku homologs does not contain the conserved N-terminal extension that is present in the eukaryotic Ku protein.


Pssm-ID: 238334 [Multi-domain]  Cd Length: 272  Bit Score: 232.16  E-value: 7.22e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 243 AWPCQLTIGSSLSIRIVGYKAVTEEKvKKSWTIVDAQSHQRDDVKRETVYClnddDETEVQKDDTIQGYRYGSDIVPFSK 322
Cdd:cd00594    3 IWKGALSLGLDVSIPVKLYSAATEEK-PPSFKQLDRKTGERVKVKRVCKYT----GGKEVEKEDIVKGYEYGGDYVPLTE 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 323 VDEEQMKYKHDgKCFSVLGFTKQELIPRHQFMGsQVVKVFAPRDDEHAAVALSSLIRALDGLKMAAIVRYAYDRRSNPQV 402
Cdd:cd00594   78 EELEQLKLETS-KGLDILGFVPASEIPPYYFDK-ESYYLVPDDSDKGSEKAFSALRRALLEKDKVAIARYVLRRNSRPRL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 403 GAAFPCIKKKYECLLYVQLPYMEDLRQFTFPMLENNKKFMPSGSQLSAVDALIDSMMLMEkdengesveiFKVNHIPNPQ 482
Cdd:cd00594  156 VALRPQEEEDPEGLVLVTLPFADDVRSYPFPLLLDIKTEKPTDEELELAKQLIDSLDLDD----------FDPEKFPNPY 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 831360240 483 FQRLFQCLHHRGVNPDDPLPPVDPwlkrVLERPQAVSARCQAPLRDVKTSF 533
Cdd:cd00594  226 LQRLYALLEAKALGEEIPEPPEDL----TLPPPEEIPKRVIDLLEALKKSL 272
Ku pfam02735
Ku70/Ku80 beta-barrel domain; The Ku heterodimer (composed of Ku70 and Ku80) contributes to ...
250-450 1.36e-58

Ku70/Ku80 beta-barrel domain; The Ku heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the central DNA-binding beta-barrel domain. This domain is found in both the Ku70 and Ku80 proteins that form a DNA binding heterodimer.


Pssm-ID: 460669  Cd Length: 197  Bit Score: 196.70  E-value: 1.36e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240  250 IGSSLSIRIVGYKAVTEEKvKKSWTIVDAQSHqrDDVKRETVYClNDDDETEVQKDDTIQGYRYGSDIVPFSKVDEEQMK 329
Cdd:pfam02735   1 IGGLVSIPVKLYSATEEEK-KPSFKKLDRETN--DGVRIKYKYV-CEDTGKEVEKEDIVKGYEYGGTYVPLSDEELEELK 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240  330 YKHDgKCFSVLGFTKQELIPRHQFMGSQVVKVFAPRDDEHAAV-ALSSLIRALDGLKMAAIVRYAYDRRSNPQVGAAFPC 408
Cdd:pfam02735  77 PEST-KGLDLLGFVPLDEIDPIYFMGDKSYFLYPDKGDIAGSTkAFSALREALLETDKVAIARFVLRRREHPRLVALRPQ 155
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 831360240  409 IKKKYECLLYVQLPYMEDLRQFTFPMLENNKKFMPSGSQLSA 450
Cdd:pfam02735 156 EEEPDPGLVLITLPFADDVREEFFPIPSLLEKPKPTEEQLDL 197
Ku78 smart00559
Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen; This is a single ...
299-438 1.83e-42

Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen; This is a single stranded DNA- and ATP-depedent helicase that has a role in chromosome translocation. This is a domain of unknown function C-terminal to its von Willebrand factor A domain, that also occurs in bacterial hypothetical proteins.


Pssm-ID: 128831 [Multi-domain]  Cd Length: 140  Bit Score: 150.52  E-value: 1.83e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240   299 ETEVQKDDTIQGYRYGSDIVPFSKVDEEQMKYKHDgKCFSVLGFTKQELIPRHQFMGSQVVKVFAPRDDEHAAVALSSLI 378
Cdd:smart00559   1 GKEVKPEDIVKGYEYGGRYVPLSDEELEQLKYKSE-PGLELLGFKPLSSLPPYYFLRPSYFLVPDDKSVIGSTKAFSALV 79
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 831360240   379 RALDGLKMAAIVRYAYDRRSNPQVGAAFPCIKKKY-ECLLYVQLPYMEDLRQFTFPMLENN 438
Cdd:smart00559  80 EALLETDKIAIARYTLRTKSNPRLVALRPYDEEDDgEGLVLVQLPFADDVRKLDFPELNTT 140
vWA_ku cd01458
Ku70/Ku80 N-terminal domain. The Ku78 heterodimer (composed of Ku70 and Ku80) contributes to ...
6-231 4.17e-37

Ku70/Ku80 N-terminal domain. The Ku78 heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks (DSB) in a preferred orientation. DSB's are repaired by either homologues recombination or non-homologues end joining and facilitate repair by the non-homologous end-joining pathway (NHEJ). The Ku heterodimer is required for accurate process that tends to preserve the sequence at the junction. Ku78 is found in all three kingdoms of life. However, only the eukaryotic proteins have a vWA domain fused to them at their N-termini. The vWA domain is not involved in DNA binding but may very likey mediate Ku78's interactions with other proteins. Members of this subgroup lack the conserved MIDAS motif.


Pssm-ID: 238735  Cd Length: 218  Bit Score: 138.26  E-value: 4.17e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240   6 KSALVLCMDVGFSMSNSGPGQEP-PFEQAKKVIQKFVQRQVFAENKDEIGLVLFGTDGTKNPlandGQYENITVHRHLMI 84
Cdd:cd01458    1 KESVVFLVDVSPSMFESKDGEYEsPFEEALKCIRQLMKSKIISSPKDLVGVVFYGTEESKNP----VGYENIYVLLDLDT 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240  85 PDFEL----------LEEIERELQPGGQQADWLDALVVCMDLLQneTMGKKYDRLNIALLTDL-----NIQTSEDQLDII 149
Cdd:cd01458   77 PGAERvedlkeliepGGLSFAGQVGDSGQVSLSDALWVCLDLFS--KGKKKKSHKRIFLFTNNddphgGDSIKDSQAAVK 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 150 IQNLKKAGITLQFFlpfpvdvedeaggggdaagpsaPPSRPGKglsrqQTQGLEMVKHIMSSLED--EDGLEEVYTFSDA 227
Cdd:cd01458  155 AEDLKDKGIELELF----------------------PLSSPGK-----KFDVSKFYKDIIALVEDanEELLDEFTEPSKD 207

                 ....
gi 831360240 228 LEKL 231
Cdd:cd01458  208 LEDL 211
Ku_N pfam03731
Ku70/Ku80 N-terminal alpha/beta domain; The Ku heterodimer (composed of Ku70 and Ku80) ...
8-240 1.27e-36

Ku70/Ku80 N-terminal alpha/beta domain; The Ku heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the amino terminal alpha/beta domain. This domain only makes a small contribution to the dimer interface. The domain comprises a six stranded beta sheet of the Rossman fold.


Pssm-ID: 427470  Cd Length: 220  Bit Score: 137.11  E-value: 1.27e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240    8 ALVLCMDVGFSMSNSGPGQEPPFEQAKKVIQKFVQRQVFAENKDEIGLVLFGTDGTKnplaNDGQYENITVHRHLMIPDF 87
Cdd:pfam03731   1 AILFVIDVSPAMFESSKLLEAPFDMALKCIRELLKSKIISRDKDLIGVVLYGTDNSE----NSEGLPNITVLRDLDLPGA 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240   88 ----------ELLEEIERELQPGGQQADWLDALVVCMDLLQNetMGKKYDRLNIALLTDL-NIQTSEDQLDIIIQNLKKA 156
Cdd:pfam03731  77 elileldqfvESFGRDVRGFSGDSSDGSLLSALWVCLELLQK--TGKKLSHKRIFLFTDLdDPFEDQDKLDIALQRLLAE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240  157 GI--TLQFFLPFPVdvedeaggggdaagPSAPPSRPGKGLSRQQTQGLEMVKHIMSSLEDEDgleevytFSDALEKLSIF 234
Cdd:pfam03731 155 DLrdTRGEFDLIHL--------------PNADGFDPNLFYKDIIKLGSDEVLNVMLDLEGQK-------LEDLLAKIRAK 213

                  ....*.
gi 831360240  235 KRIERR 240
Cdd:pfam03731 214 KTAKRA 219
Ku_PK_bind pfam08785
Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by ...
588-701 3.17e-33

Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This domain is found at the C terminal of Ku which binds to DNA-PKcs.


Pssm-ID: 462604  Cd Length: 117  Bit Score: 123.85  E-value: 3.17e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240  588 NPARDFCTLIRQKTV--SFDQACQQLTHRIEQLLGNR-STEYYTKSIACIQAFRDQSVLSGNAELFNSYLQSLKRSIADR 664
Cdd:pfam08785   1 NPVPDFKQLLARGDDvdAVEKAVKQMGNIIEDLVRDSfGDSNYDKALECLRALREECIEEEEPDLYNDFLRDLKKKLLEG 80
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 831360240  665 SLQDFWNLLAQDALTLISKDEVEASTISKQEANQFLS 701
Cdd:pfam08785  81 DRREFWELVRKNKLGLITKDEAEDSDVTEEEAKEFLS 117
KU70 cd00788
Ku-core domain, Ku70 subfamily; Ku70 is a subunit of the Ku protein, which plays a key role in ...
246-492 6.32e-14

Ku-core domain, Ku70 subfamily; Ku70 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the regulation of all the diverse functions of Ku is still unclear, although it seems that Ku is a multifunctional protein that works in the nuclei. In mammalian cells, the Ku heterodimer recruits the catalytic subunit of DNA-dependent protein kinase (DNA-PK), which is dependent on its association with the Ku70/80 heterodimer bound to DNA for its protein kinase activity.


Pssm-ID: 238407 [Multi-domain]  Cd Length: 287  Bit Score: 72.70  E-value: 6.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 246 CQLTIG--SSLSIRIVGYKAVTEEKVKKSWTIVDAQSHQRDDVKRETVYcLNDDDETEVQKDDTIQGYRYGSDIVPFSKV 323
Cdd:cd00788    6 LPLELGpgNKLVISVKGYSLVSHAKKPRKYKLDREKNEERREVKSKRKF-FDVESGKTLEKADIKKGYKIGGEKIIFTKE 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 324 DEEQMKYKHDgKCFSVLGFTKQELIPRHQFMG-SQVVkvfAPRDDEHA--AVALSSLIRALDGLKMAAIVRYAydRRSN- 399
Cdd:cd00788   85 ELKKIKSFGE-PGLRLIGFKPRSTLKPYHNIKkSYFI---YPDESDYKgsTRLFAALLRSCLKKNKVAICWYI--LRKNs 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240 400 --------PQVGAAFPCIKKKYECLLY-VQLPYMEDLRQFtfpmlenNKKFMPSGSQLSAVDALIDSM-MLMEKDENGEs 469
Cdd:cd00788  159 pprlvalvPQEEELDEPDGQVLPPGFHlVPLPFADDIRKL-------PSLLEENASAESASDELVDKAkQIIKKLRLLS- 230
                        250       260
                 ....*....|....*....|...
gi 831360240 470 veiFKVNHIPNPQFQRLFQCLHH 492
Cdd:cd00788  231 ---YDPDKFPNPSLQKHYKILEA 250
Ku_C pfam03730
Ku70/Ku80 C-terminal arm; The Ku heterodimer (composed of Ku70 and Ku80) contributes to ...
473-565 5.15e-13

Ku70/Ku80 C-terminal arm; The Ku heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the C terminal arm. This alpha helical region embraces the beta-barrel domain pfam02735 of the opposite subunit.


Pssm-ID: 461029  Cd Length: 79  Bit Score: 64.60  E-value: 5.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240  473 FKVNHIPNPQFQRLFQCLHHRGVNpddpLPPVDPWLKRVLERPQAVSARCQAPLRDVKTSFPLKVVVKkkeqktsadvfG 552
Cdd:pfam03730   2 YNPDKFPNPSLQRHYQNLQALALD----EDEPEEPEDLTLPKYEAIDKRIGKLLEEFKELFELEDYKP-----------D 66
                          90
                  ....*....|...
gi 831360240  553 SSADEPDAKKVKV 565
Cdd:pfam03730  67 EDEEGPAAKKAKI 79
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
9-163 4.68e-07

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 50.53  E-value: 4.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240     9 LVLCMDVGFSMSNSgpgqepPFEQAKKVIQKFVQRQVFAENKDEIGLVLFGTDGTknPLANDGQYENITVHRHLMipdfe 88
Cdd:smart00327   2 VVFLLDGSGSMGGN------RFELAKEFVLKLVEQLDIGPDGDRVGLVTFSDDAR--VLFPLNDSRSKDALLEAL----- 68
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 831360240    89 lleeiERELQPGGQQADWLDALVVCMDLLQNETMGKKYDRLNIA-LLTDLNIQTSEDQLDIIIQNLKKAGITLQFF 163
Cdd:smart00327  69 -----ASLSYKLGGGTNLGAALQYALENLFSKSAGSRRGAPKVViLITDGESNDGPKDLLKAAKELKRSGVKVFVV 139
vWFA cd00198
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
9-160 5.08e-06

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


Pssm-ID: 238119 [Multi-domain]  Cd Length: 161  Bit Score: 47.18  E-value: 5.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240   9 LVLCMDVGFSMSnsgpgqEPPFEQAKKVIQKFVQRQVFAENKDEIGLVLFGTDGTknPLANDGQYENITVHRHLMipdfe 88
Cdd:cd00198    3 IVFLLDVSGSMG------GEKLDKAKEALKALVSSLSASPPGDRVGLVTFGSNAR--VVLPLTTDTDKADLLEAI----- 69
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 831360240  89 lleeiERELQPGGQQADWLDALVVCMDLLQNETmgKKYDRLNIALLTDLNIQTSEDQLDIIIQNLKKAGITL 160
Cdd:cd00198   70 -----DALKKGLGGGTNIGAALRLALELLKSAK--RPNARRVIILLTDGEPNDGPELLAEAARELRKLGITV 134
vWA_BatA_type cd01467
VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood ...
9-70 1.48e-04

VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif.


Pssm-ID: 238744 [Multi-domain]  Cd Length: 180  Bit Score: 43.09  E-value: 1.48e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 831360240   9 LVLCMDVGFSMSNSGPGQEPPFEQAKKVIQKFVQRQvfaeNKDEIGLVLFGTDG-TKNPLAND 70
Cdd:cd01467    5 IMIALDVSGSMLAQDFVKPSRLEAAKEVLSDFIDRR----ENDRIGLVVFAGAAfTQAPLTLD 63
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
9-160 2.51e-04

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 43.39  E-value: 2.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 831360240   9 LVLCMDVGFSMsnsgpGQEPPFEQAKKVIQKFVQRqvfAENKDEIGLVLFGTDG-TKNPLANDGQyeniTVHRHLMipdf 87
Cdd:COG1240   95 VVLVVDASGSM-----AAENRLEAAKGALLDFLDD---YRPRDRVGLVAFGGEAeVLLPLTRDRE----ALKRALD---- 158
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 831360240  88 elleeierELQPGGqQADWLDALVVCMDLLQNETMGKKydRLnIALLTDLNIQTSEDQLDIIIQNLKKAGITL 160
Cdd:COG1240  159 --------ELPPGG-GTPLGDALALALELLKRADPARR--KV-IVLLTDGRDNAGRIDPLEAAELAAAAGIRI 219
VWA_2 pfam13519
von Willebrand factor type A domain;
9-61 8.07e-04

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 39.20  E-value: 8.07e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 831360240    9 LVLCMDVGFSMSNSGPGQePPFEQAKKVIQKFVQRQvfaeNKDEIGLVLFGTD 61
Cdd:pfam13519   1 LVFVLDTSGSMRNGDYGP-TRLEAAKDAVLALLKSL----PGDRVGLVTFGDG 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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