NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|269308222|ref|NP_001014421|]
View 

target of Nesh-SH3 isoform 3 precursor [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 673-764 1.41e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 1.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 673 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 750
Cdd:cd00063    2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 269308222 751 LGEGPASNTVAFST 764
Cdd:cd00063   80 GGESPPSESVTVTT 93
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 291-675 3.73e-08

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.49  E-value: 3.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  291 MLEISDALKAQLAKNETLAlpAESKTPEVEKLAGQPVTVTPESVSRSTKPTLSSALDTAETALAPRQTTSMPPKLKTPHS 370
Cdd:PHA03307   42 QLVSDSAELAAVTVVAGAA--ACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPP 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  371 RMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSAPLETRGIPLIPVISPRPSQEELQTAMeetdqsTQELFTTKIPRTTEL 450
Cdd:PHA03307  120 TPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSS------PEETARAPSSPPAEP 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  451 AKTTQAPHRLHTAPVR--PRIPGRPHGRPALNKTTTRPDKTKPRGTSHKNGVGTG---TKQAPKP-------PSPGRNAS 518
Cdd:PHA03307  194 PPSTPPAAASPRPPRRssPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpENECPLPrpapitlPTRIWEAS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  519 VDSHATRKPGSVSGTRRPPIPH-RHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAE 597
Cdd:PHA03307  274 GWNGPSSRPGPASSSSSPRERSpSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSP 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  598 Q--KEPTAPASEEEFGTTTDFSSSPTKEtdplgKPRFIGPHVRYIPKPENKP---CSITDSVRRFPTEEATEGNATSPPQ 672
Cdd:PHA03307  354 SrpPPPADPSSPRKRPRPSRAPSSPAAS-----AGRPTRRRARAAVAGRARRrdaTGRFPAGRPRPSPLDAGAASGAFYA 428


                  ...
gi 269308222  673 NPP 675
Cdd:PHA03307  429 RYP 431
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 1.93e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                 ....
gi 269308222 192 FGVK 195
Cdd:cd00063   72 FRVR 75
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 673-764 1.41e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 1.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 673 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 750
Cdd:cd00063    2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 269308222 751 LGEGPASNTVAFST 764
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 674-754 7.55e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.39  E-value: 7.55e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222   674 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQITNQTFS-TVENLKPDTSYEFQVKPKNPL 751
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 269308222   752 GEG 754
Cdd:smart00060  81 GEG 83
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 291-675 3.73e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.49  E-value: 3.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  291 MLEISDALKAQLAKNETLAlpAESKTPEVEKLAGQPVTVTPESVSRSTKPTLSSALDTAETALAPRQTTSMPPKLKTPHS 370
Cdd:PHA03307   42 QLVSDSAELAAVTVVAGAA--ACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPP 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  371 RMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSAPLETRGIPLIPVISPRPSQEELQTAMeetdqsTQELFTTKIPRTTEL 450
Cdd:PHA03307  120 TPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSS------PEETARAPSSPPAEP 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  451 AKTTQAPHRLHTAPVR--PRIPGRPHGRPALNKTTTRPDKTKPRGTSHKNGVGTG---TKQAPKP-------PSPGRNAS 518
Cdd:PHA03307  194 PPSTPPAAASPRPPRRssPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpENECPLPrpapitlPTRIWEAS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  519 VDSHATRKPGSVSGTRRPPIPH-RHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAE 597
Cdd:PHA03307  274 GWNGPSSRPGPASSSSSPRERSpSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSP 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  598 Q--KEPTAPASEEEFGTTTDFSSSPTKEtdplgKPRFIGPHVRYIPKPENKP---CSITDSVRRFPTEEATEGNATSPPQ 672
Cdd:PHA03307  354 SrpPPPADPSSPRKRPRPSRAPSSPAAS-----AGRPTRRRARAAVAGRARRrdaTGRFPAGRPRPSPLDAGAASGAFYA 428


                  ...
gi 269308222  673 NPP 675
Cdd:PHA03307  429 RYP 431
fn3 pfam00041
Fibronectin type III domain;
674-757 1.39e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.72  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  674 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQITNQTFS-TVENLKPDTSYEFQVKPKNP 750
Cdd:pfam00041   2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 269308222  751 LGEGPAS 757
Cdd:pfam00041  79 GGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
658-769 8.78e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 49.62  E-value: 8.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 658 PTEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSGKNKSIQITNQTFSTVENLKP 737
Cdd:COG3401  220 PSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DGPFTKVATVTTTSYTDTGLTN 294

                         90       100       110
                 ....*....|....*....|....*....|...
gi 269308222 738 DTSYEFQVKPKNPLG-EGPASNTVAFSTESADP 769
Cdd:COG3401  295 GTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 287-676 9.44e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.77  E-value: 9.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  287 PTSIMLEISDALKAQLAKNETLALPAESKTPEVEKLAGQPVTVTpesvsrsTKPTLSSALDTAETALAPRQTTSMPPKLK 366
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPAT-------SQPPNQTQSTAAPHTLIQQTPTLHPQRLP 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  367 TPHS---RMPAKEPVPKEPLHTTSKP----KMPPSPEvadttsaPLETrGIPLIPviSPRPSQeelqtAMEETDQSTQel 439
Cdd:pfam03154 244 SPHPplqPMTQPPPPSQVSPQPLPQPslhgQMPPMPH-------SLQT-GPSHMQ--HPVPPQ-----PFPLTPQSSQ-- 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  440 ftTKIPRTTELAKTTQAPHRLHTAPVRPR-----------IPGRPHGRPALNKTTTRPDKTKPRGTSHKNgvgTGTKQAP 508
Cdd:pfam03154 307 --SQVPPGPSPAAPGQSQQRIHTPPSQSQlqsqqppreqpLPPAPLSMPHIKPPPTTPIPQLPNPQSHKH---PPHLSGP 381

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  509 KPPSpgRNASVDSHATRKPGSVSGTRRPpiPHRHSSTRPVSPERRPLPPnnvtgKPGRAGIVSSSRVTSPPlkATLHPig 588
Cdd:pfam03154 382 SPFQ--MNSNLPPPPALKPLSSLSTHHP--PSAHPPPLQLMPQSQQLPP-----PPAQPPVLTQSQSLPPP--AASHP-- 448

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  589 tataRPGAEQKEPTAPAseeeFGTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSV-------------R 655
Cdd:pfam03154 449 ----PTSGLHQVPSQSP----FPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVpaavscplppvqiK 520

                         410       420
                  ....*....|....*....|.
gi 269308222  656 RFPTEEATEGNATSPPQNPPT 676
Cdd:pfam03154 521 EEALDEAEEPESPPPPPRSPS 541
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 1.93e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                 ....
gi 269308222 192 FGVK 195
Cdd:cd00063   72 FRVR 75
fn3 pfam00041
Fibronectin type III domain;
116-195 2.66e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 2.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                  ...
gi 269308222  193 GVK 195
Cdd:pfam00041  72 RVQ 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 114-195 3.10e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 3.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222   114 PRKPLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPSDRFYTIRYREKDKEKKWIFQLCPA----TETIVENLKPNTV 189
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTE 69


                   ....*.
gi 269308222   190 YEFGVK 195
Cdd:smart00060  70 YEFRVR 75
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 314-404 3.00e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 40.99  E-value: 3.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 314 SKTPEVeklAGQPVTVTPESVSRSTKPTlssalDTAETALAPRQTTSMPPklktphsrmpakEPVPKEPLHTTSKPKMPP 393
Cdd:COG3266  279 SLPPAV---AAQPAAAAAAQPSAVALPA-----APAAAAAAAAPAEAAAP------------QPTAAKPVVTETAAPAAP 338

                         90
                 ....*....|.
gi 269308222 394 SPEVADTTSAP 404
Cdd:COG3266  339 APEAAAAAAAP 349
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 673-764 1.41e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 1.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 673 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 750
Cdd:cd00063    2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 269308222 751 LGEGPASNTVAFST 764
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 674-754 7.55e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.39  E-value: 7.55e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222   674 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQITNQTFS-TVENLKPDTSYEFQVKPKNPL 751
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 269308222   752 GEG 754
Cdd:smart00060  81 GEG 83
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 291-675 3.73e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.49  E-value: 3.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  291 MLEISDALKAQLAKNETLAlpAESKTPEVEKLAGQPVTVTPESVSRSTKPTLSSALDTAETALAPRQTTSMPPKLKTPHS 370
Cdd:PHA03307   42 QLVSDSAELAAVTVVAGAA--ACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPP 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  371 RMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSAPLETRGIPLIPVISPRPSQEELQTAMeetdqsTQELFTTKIPRTTEL 450
Cdd:PHA03307  120 TPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSS------PEETARAPSSPPAEP 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  451 AKTTQAPHRLHTAPVR--PRIPGRPHGRPALNKTTTRPDKTKPRGTSHKNGVGTG---TKQAPKP-------PSPGRNAS 518
Cdd:PHA03307  194 PPSTPPAAASPRPPRRssPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpENECPLPrpapitlPTRIWEAS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  519 VDSHATRKPGSVSGTRRPPIPH-RHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAE 597
Cdd:PHA03307  274 GWNGPSSRPGPASSSSSPRERSpSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSP 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  598 Q--KEPTAPASEEEFGTTTDFSSSPTKEtdplgKPRFIGPHVRYIPKPENKP---CSITDSVRRFPTEEATEGNATSPPQ 672
Cdd:PHA03307  354 SrpPPPADPSSPRKRPRPSRAPSSPAAS-----AGRPTRRRARAAVAGRARRrdaTGRFPAGRPRPSPLDAGAASGAFYA 428


                  ...
gi 269308222  673 NPP 675
Cdd:PHA03307  429 RYP 431
PHA03247 PHA03247
large tegument protein UL36; Provisional
 362-683 9.73e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.49  E-value: 9.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  362 PPKLKTPHSRMPAKEPVPKEPlhttSKPKMPPSPEVADTTSAPLETRGIPLIP-VISPRPSQEELqtAMEETDQSTQELF 440
Cdd:PHA03247 2483 PAEARFPFAAGAAPDPGGGGP----PDPDAPPAPSRLAPAILPDEPVGEPVHPrMLTWIRGLEEL--ASDDAGDPPPPLP 2556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  441 TTKIPRTTELAKTTQAPhrlhtAPvrpripgRPHGrPALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPgrnASVD 520
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRP-----AP-------RPSE-PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSP---LPPD 2620

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  521 SHATRKPGSVSGTR--RPPIPHRHSSTRPVSPERRPLPP----NNVTGKPGRAGIVSSS--RVTSPPLKATLHPIgTATA 592
Cdd:PHA03247 2621 THAPDPPPPSPSPAanEPDPHPPPTVPPPERPRDDPAPGrvsrPRRARRLGRAAQASSPpqRPRRRAARPTVGSL-TSLA 2699

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  593 RPGAEQKEP------TAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSitdsvrrfPTEEATEGN 666
Cdd:PHA03247 2700 DPPPPPPTPepaphaLVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT--------TAGPPAPAP 2771

                         330
                  ....*....|....*..
gi 269308222  667 ATSPPQNPPTNLTVVTV 683
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPAV 2788
PHA03247 PHA03247
large tegument protein UL36; Provisional
 326-675 1.35e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 1.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  326 PVTVTPESVSRSTKPTLSSALDTAETALAPR-------QTTSMPPKLKTPHSRMPAKEPVPKEPlhTTSKPKMPPSPEVA 398
Cdd:PHA03247 2575 PRPSEPAVTSRARRPDAPPQSARPRAPVDDRgdprgpaPPSPLPPDTHAPDPPPPSPSPAANEP--DPHPPPTVPPPERP 2652

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  399 DTTSAPletrgiplipvisPRPSQEELQTAMEETDQSTQelfTTKIPRtTELAKTTQAPhrlHTAPVRPRIPGRPhgrPA 478
Cdd:PHA03247 2653 RDDPAP-------------GRVSRPRRARRLGRAAQASS---PPQRPR-RRAARPTVGS---LTSLADPPPPPPT---PE 2709

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  479 LNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDSHATR--KPGSVSGTRRPPIPhrhsSTRPVSPERRPLP 556
Cdd:PHA03247 2710 PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARpaRPPTTAGPPAPAPP----AAPAAGPPRRLTR 2785

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  557 PNNVTGKPGRAGIVSSSRVTSPPLKATL-HPIGTATARPGAEQKEPTAPASeeefgTTTDFSSSPTKETDPLGKPRFIGP 635
Cdd:PHA03247 2786 PAVASLSESRESLPSPWDPADPPAAVLApAAALPPAASPAGPLPPPTSAQP-----TAPPPPPGPPPPSLPLGGSVAPGG 2860

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 269308222  636 HVRYIPKPENKPCSITDSVR-------RFPTEEATEGNATSPPQNPP 675
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARppvrrlaRPAVSRSTESFALPPDQPER 2907
fn3 pfam00041
Fibronectin type III domain;
674-757 1.39e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.72  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  674 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQITNQTFS-TVENLKPDTSYEFQVKPKNP 750
Cdd:pfam00041   2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 269308222  751 LGEGPAS 757
Cdd:pfam00041  79 GGEGPPS 85
PHA03247 PHA03247
large tegument protein UL36; Provisional
 311-695 1.46e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  311 PAESKTPEVEKLAGQPVTVT-PESVSRSTKPTLSSALDTAETALAPRQTTSM-------PPKLKTPHSRMPAKEPVPKEP 382
Cdd:PHA03247 2643 PPTVPPPERPRDDPAPGRVSrPRRARRLGRAAQASSPPQRPRRRAARPTVGSltsladpPPPPPTPEPAPHALVSATPLP 2722

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  383 LHTTSKPKMPPSPEVADTTSAPLETRGIPLIPVISPRPSqeelQTAMEETDQSTQELFTTKIPRTTELAKTTQAPHRlHT 462
Cdd:PHA03247 2723 PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPP----TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESR-ES 2797

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  463 APVrPRIPGrPHGRPALNKTTTRPDKTKPRGTSHKNgvGTGTKQAPKPPSPGRNASVDSHATRKPGSvSGTRRPPiphrh 542
Cdd:PHA03247 2798 LPS-PWDPA-DPPAAVLAPAAALPPAASPAGPLPPP--TSAQPTAPPPPPGPPPPSLPLGGSVAPGG-DVRRRPP----- 2867

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  543 SSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTK 622
Cdd:PHA03247 2868 SRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT 2947

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 269308222  623 ETDPLGKPRFIGPHvryiPKPENKPCSITDSVRRFPTEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWE 695
Cdd:PHA03247 2948 DPAGAGEPSGAVPQ----PWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016
PHA03247 PHA03247
large tegument protein UL36; Provisional
 287-635 1.22e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  287 PTSIMLEISDALKAQLAKNETLALPAESKTPEVEKLAGQPVTVTPESV---------------------SRSTKPTLSSA 345
Cdd:PHA03247 2712 PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARppttagppapappaapaagppRRLTRPAVASL 2791

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  346 LDTAETALAPRQTTSMPPKLKTPHSRMPAKE-PVPKEPLHTTSKPKMPPSPEVADTTSAPLETRGIPLIPVISPRPSQEE 424
Cdd:PHA03247 2792 SESRESLPSPWDPADPPAAVLAPAAALPPAAsPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSP 2871

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  425 LQTAMEETDQSTQELFTTKIPRTTE---LAKTTQAPHRLHTAPVRPRIPGRPHGRPalnkTTTRPDKTKPRgtshkngvg 501
Cdd:PHA03247 2872 AAKPAAPARPPVRRLARPAVSRSTEsfaLPPDQPERPPQPQAPPPPQPQPQPPPPP----QPQPPPPPPPR--------- 2938

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  502 tgtKQAPKPPSPG-RNASVDSHATRKP--GSVSGTRRPPIPHRHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSS----- 573
Cdd:PHA03247 2939 ---PQPPLAPTTDpAGAGEPSGAVPQPwlGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSlalhe 3015

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 269308222  574 RVTSPP--LKATLHP---------IGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPR-FIGP 635
Cdd:PHA03247 3016 ETDPPPvsLKQTLWPpddtedsdaDSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSsQFGP 3089
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
658-769 8.78e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 49.62  E-value: 8.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 658 PTEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSGKNKSIQITNQTFSTVENLKP 737
Cdd:COG3401  220 PSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DGPFTKVATVTTTSYTDTGLTN 294

                         90       100       110
                 ....*....|....*....|....*....|...
gi 269308222 738 DTSYEFQVKPKNPLG-EGPASNTVAFSTESADP 769
Cdd:COG3401  295 GTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 287-676 9.44e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.77  E-value: 9.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  287 PTSIMLEISDALKAQLAKNETLALPAESKTPEVEKLAGQPVTVTpesvsrsTKPTLSSALDTAETALAPRQTTSMPPKLK 366
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPAT-------SQPPNQTQSTAAPHTLIQQTPTLHPQRLP 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  367 TPHS---RMPAKEPVPKEPLHTTSKP----KMPPSPEvadttsaPLETrGIPLIPviSPRPSQeelqtAMEETDQSTQel 439
Cdd:pfam03154 244 SPHPplqPMTQPPPPSQVSPQPLPQPslhgQMPPMPH-------SLQT-GPSHMQ--HPVPPQ-----PFPLTPQSSQ-- 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  440 ftTKIPRTTELAKTTQAPHRLHTAPVRPR-----------IPGRPHGRPALNKTTTRPDKTKPRGTSHKNgvgTGTKQAP 508
Cdd:pfam03154 307 --SQVPPGPSPAAPGQSQQRIHTPPSQSQlqsqqppreqpLPPAPLSMPHIKPPPTTPIPQLPNPQSHKH---PPHLSGP 381

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  509 KPPSpgRNASVDSHATRKPGSVSGTRRPpiPHRHSSTRPVSPERRPLPPnnvtgKPGRAGIVSSSRVTSPPlkATLHPig 588
Cdd:pfam03154 382 SPFQ--MNSNLPPPPALKPLSSLSTHHP--PSAHPPPLQLMPQSQQLPP-----PPAQPPVLTQSQSLPPP--AASHP-- 448

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  589 tataRPGAEQKEPTAPAseeeFGTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSV-------------R 655
Cdd:pfam03154 449 ----PTSGLHQVPSQSP----FPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVpaavscplppvqiK 520

                         410       420
                  ....*....|....*....|.
gi 269308222  656 RFPTEEATEGNATSPPQNPPT 676
Cdd:pfam03154 521 EEALDEAEEPESPPPPPRSPS 541
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
658-809 1.18e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 49.23  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 658 PTEEATEGNATSPPQnPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV--ISRENGSFSGKNKSIqitNQTFSTVENL 735
Cdd:COG3401  314 PSNVVSVTTDLTPPA-APSGLTATAVG--SSSITLSWTASSDADVTGYNVyrSTSGGGTYTKIAETV---TTTSYTDTGL 387

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 736 KPDTSYEFQVKPKNPLG-EGPASNTVAFSTESADPRVS----------EPISAGRDAIWTERPFNSDSYSECKGKQYVKR 804
Cdd:COG3401  388 TPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESltasvdavplTDVAGATAAASAASNPGVSAAVLADGGDTGNA 467


                 ....*
gi 269308222 805 TWYKK 809
Cdd:COG3401  468 VPFTT 472
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 303-669 1.58e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 48.76  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  303 AKNETLALPAESKTPeveklagqpvtvTPESVSRSTKPTLSSALDTAETalaPRQTTSMPPKLkTPhsrmpakEPVPKEP 382
Cdd:pfam05109 441 APNTTTGLPSSTHVP------------TNLTAPASTGPTVSTADVTSPT---PAGTTSGASPV-TP-------SPSPRDN 497

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  383 LHTTSKPKMPpSPEVADTTSAPLETRGIPLIPVISPRPSQEELQTAmeetdqSTQELFTTKIPRTTELAKTTQAPHRLHT 462
Cdd:pfam05109 498 GTESKAPDMT-SPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKT------SPTSAVTTPTPNATSPTPAVTTPTPNAT 570

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  463 APVRPRI-PGRPHGRPALNKTTTRPDKTKPRGTSHKNGVGtGTKQAPKPPSPGRNA-------------SVDSHATRKPG 528
Cdd:pfam05109 571 IPTLGKTsPTSAVTTPTPNATSPTVGETSPQANTTNHTLG-GTSSTPVVTSPPKNAtsavttgqhnitsSSTSSMSLRPS 649

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  529 SVSGTRRPPIPHRHSSTRPVSPERRPLPPNNVTgkpgragivsssRVTspPLKATLHPIGTAT--ARPGAeqkepTAPAS 606
Cdd:pfam05109 650 SISETLSPSTSDNSTSHMPLLTSAHPTGGENIT------------QVT--PASTSTHHVSTSSpaPRPGT-----TSQAS 710

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 269308222  607 EEEFGTTtdfSSSPTKETDPLGKPrfigphvryiPKPENKPCSITDSVRRFPTEEATEGNATS 669
Cdd:pfam05109 711 GPGNSST---STKPGEVNVTKGTP----------PKNATSPQAPSGQKTAVPTVTSTGGKANS 760
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 1.93e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                 ....
gi 269308222 192 FGVK 195
Cdd:cd00063   72 FRVR 75
fn3 pfam00041
Fibronectin type III domain;
116-195 2.66e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 2.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                  ...
gi 269308222  193 GVK 195
Cdd:pfam00041  72 RVQ 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 114-195 3.10e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 3.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222   114 PRKPLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPSDRFYTIRYREKDKEKKWIFQLCPA----TETIVENLKPNTV 189
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTE 69


                   ....*.
gi 269308222   190 YEFGVK 195
Cdd:smart00060  70 YEFRVR 75
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 308-555 3.26e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 47.78  E-value: 3.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 308 LALPAESKTPEVEKLAGQ-PVTVTPESVSRSTKPTLSSALDTAETALAPRQTTSMPPKLKT-------------PHSRMP 373
Cdd:PRK08691 361 LAAASCDANAVIENTELQsPSAQTAEKETAAKKPQPRPEAETAQTPVQTASAAAMPSEGKTagpvsnqenndvpPWEDAP 440

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 374 --AKEPVPKEPL-----HTTSKPKMPPSPEVADTTSAPLETRGiPLIPVISPRPSQ-----EELQTAMEETDQSTQELFT 441
Cdd:PRK08691 441 deAQTAAGTAQTsaksiQTASEAETPPENQVSKNKAADNETDA-PLSEVPSENPIQatpndEAVETETFAHEAPAEPFYG 519

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 442 TKIPRTTELAKTtqaphrlhTAPVRPriPGRPHGRPALNKTTTRPDKTKPRGTSHKNgvgtgTKQAPKPPSPGRN-ASVD 520
Cdd:PRK08691 520 YGFPDNDCPPED--------GAEIPP--PDWEHAAPADTAGGGADEEAEAGGIGGNN-----TPSAPPPEFSTENwAAIV 584

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 269308222 521 SHATRKPGSVSgtrrppIPHRHSSTRPVSPERRPL 555
Cdd:PRK08691 585 RHFARKLGAAQ------MPAQHSAWTEYHPDTGLM 613
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 334-555 4.00e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.47  E-value: 4.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  334 VSRSTKPTLSSALDTAETALAPRQTT--SMPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPPSPevadttSAPLETRGIP 411
Cdd:PHA03307  230 DDAGASSSDSSSSESSGCGWGPENECplPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRE------RSPSPSPSSP 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  412 LIPVISPRPSQEELQTAmeetdqstqelfttkiPRTTELAKTTQAPHRLHTAPVRPRIPGRPHGRPALNKTTTRPDKTKP 491
Cdd:PHA03307  304 GSGPAPSSPRASSSSSS----------------SRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRK 367

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 269308222  492 RGTSHKNGvGTGTKQAPKPPSPGRNASVDSHATR--KPGSVSGTRRPPIPHRHSSTRPVSPERRPL 555
Cdd:PHA03307  368 RPRPSRAP-SSPAASAGRPTRRRARAAVAGRARRrdATGRFPAGRPRPSPLDAGAASGAFYARYPL 432
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 310-564 6.17e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.99  E-value: 6.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 310 LPAESKTPEVEKLAGQPVTvtPESVSRSTKPTLSSALDTAETALAPrQTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKP 389
Cdd:PTZ00449 572 IPTLSKKPEFPKDPKHPKD--PEEPKKPKRPRSAQRPTRPKSPKLP-ELLDIPKSPKRPESPKSPKRPPPPQRPSSPERP 648

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 390 KMPPSPEvadtTSAPLETRGIPLIPVISPRPSQEELQTA--MEET------DQSTQELFTTKIPRTTELAKTTQAPhrlh 461
Cdd:PTZ00449 649 EGPKIIK----SPKPPKSPKPPFDPKFKEKFYDDYLDAAakSKETkttvvlDESFESILKETLPETPGTPFTTPRP---- 720

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 462 TAPVRPRIPGRPHGRPAlnktttRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDSHATRKPGSVSGTRRPPIPHR 541
Cdd:PTZ00449 721 LPPKLPRDEEFPFEPIG------DPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEAMK 794

                        250       260
                 ....*....|....*....|....
gi 269308222 542 hsstRPVSP-ERRPLPPNNVTGKP 564
Cdd:PTZ00449 795 ----RPDSPsEHEDKPPGDHPSLP 814
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 387-747 1.35e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.84  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 387 SKPKMPP-SPEVADTTSAPLETRGIPLIPVISPRPSQEElqTAMEETDQSTQELFTTKIPRTTELAKTTQAPhrlhtAPV 465
Cdd:PTZ00449 492 SKKKLAPiEEEDSDKHDEPPEGPEASGLPPKAPGDKEGE--EGEHEDSKESDEPKEGGKPGETKEGEVGKKP-----GPA 564

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 466 RPRipgRPHGRPALNKTTTRPDKTKprgtshkngvgtgtkqAPKPPSPGRnasvdshATRKPGSVSGTRRPPIPHR-HSS 544
Cdd:PTZ00449 565 KEH---KPSKIPTLSKKPEFPKDPK----------------HPKDPEEPK-------KPKRPRSAQRPTRPKSPKLpELL 618

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 545 TRPVSPERRPLPPNnvtgkPGRAgiVSSSRVTSPplKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKET 624
Cdd:PTZ00449 619 DIPKSPKRPESPKS-----PKRP--PPPQRPSSP--ERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKET 689

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 625 DPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEATEGNATSPPQNP------PTNLTVVTVEGCPSFVILDWEKPL 698
Cdd:PTZ00449 690 KTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPdaeqpdDIEFFTPPEEERTFFHETPADTPL 769

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 269308222 699 NDTVTEyevisrengsfsgKNKSIQITNQTFSTVENLK-PDTSYEFQVKP 747
Cdd:PTZ00449 770 PDILAE-------------EFKEEDIHAETGEPDEAMKrPDSPSEHEDKP 806
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 316-567 1.51e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  316 TPEVEKLAGQPVTVTPESVSRSTKPTLSSALDTAETALAPRQTTSMPPKLKTPHSRMPAKEPVP--------KEPLHTTS 387
Cdd:pfam03154 301 TPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPqlpnpqshKHPPHLSG 380

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  388 KP------KMPPSPEVADTTSAPLETRGIPLIPVISPRPSQEELQTAMEETDQSTQelfTTKIPRTTELAKTTQAPHRLH 461
Cdd:pfam03154 381 PSpfqmnsNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQ---SQSLPPPAASHPPTSGLHQVP 457

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  462 TAPVRPRIPGRPHGRPALNKTTTRPDKTKPRGTshkngvgtgTKQAPKPPSPGRNASVdshatrkPGSVSGTRRP----- 536
Cdd:pfam03154 458 SQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMP---------GIQPPSSASVSSSGPV-------PAAVSCPLPPvqike 521

                         250       260       270
                  ....*....|....*....|....*....|..
gi 269308222  537 -PIPHRHSSTRPVSPERRPLPPNNVTGKPGRA 567
Cdd:pfam03154 522 eALDEAEEPESPPPPPRSPSPEPTVVNTPSHA 553
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
670-769 2.21e-03

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 41.30  E-value: 2.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 670 PPQNPpTNLTVVTVEgcPSFVILDWEK-PLNDTVTEYEVisrengsFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPK 748
Cdd:COG3979    2 APTAP-TGLTASNVT--SSSVSLSWDAsTDNVGVTGYDV-------YRGGDQVATVTGLTAWTVTGLTPGTEYTFTVGAC 71

                         90       100
                 ....*....|....*....|.
gi 269308222 749 nplgeGPASNTVAFSTESADP 769
Cdd:COG3979   72 -----DAAGNVSAASGTSTAM 87
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
362-541 2.56e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 41.19  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  362 PPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSAPLETRGIPLI------------PVISPRPSQEELQTam 429
Cdd:pfam05539 168 PKTAVTTSKTTSWPTEVSHPTYPSQVTPQSQPATQGHQTATANQRLSSTEPVgtqgtttssnpePQTEPPPSQRGPSG-- 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  430 eetdqSTQELFTTKIPRTtelakTTQAPHRLHTApvRPRIPGRPHGRPALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPK 509
Cdd:pfam05539 246 -----SPQHPPSTTSQDQ-----STTGDGQEHTQ--RRKTPPATSNRRSPHSTATPPPTTKRQETGRPTPRPTATTQSGS 313

                         170       180       190
                  ....*....|....*....|....*....|..
gi 269308222  510 PPSPGRNASVDSHATRKPGSVSGTRRPPIPHR 541
Cdd:pfam05539 314 SPPHSSPPGVQANPTTQNLVDCKELDPPKPNS 345
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 314-404 3.00e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 40.99  E-value: 3.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 314 SKTPEVeklAGQPVTVTPESVSRSTKPTlssalDTAETALAPRQTTSMPPklktphsrmpakEPVPKEPLHTTSKPKMPP 393
Cdd:COG3266  279 SLPPAV---AAQPAAAAAAQPSAVALPA-----APAAAAAAAAPAEAAAP------------QPTAAKPVVTETAAPAAP 338

                         90
                 ....*....|.
gi 269308222 394 SPEVADTTSAP 404
Cdd:COG3266  339 APEAAAAAAAP 349
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 318-589 5.26e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 40.43  E-value: 5.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 318 EVEKLAGQPVTVTPESVSRSTKPTLSSALDTAETALAPRQTTSMPPKLKTPHSRMPAKEPVPKEPlhtTSKPKMPPSPEV 397
Cdd:COG5180  213 EPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATVDAQPEMRPPADAKERRRAAIGDTPAAEP---PGLPVLEAGSEP 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 398 ADTTSAPLETRGIPLIPVISPRPSQEELQTAMEETDQSTQEL-FTTKIPRTTELAKTTQAPHRLHTAPVRPRIPGRP--- 473
Cdd:COG5180  290 QSDAPEAETARPIDVKGVASAPPATRPVRPPGGARDPGTPRPgQPTERPAGVPEAASDAGQPPSAYPPAEEAVPGKPleq 369

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222 474 -HGRPAlNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDShATRKPGSVSGTRRPPIPHR--HSSTRPVSP 550
Cdd:COG5180  370 gAPRPG-SSGGDGAPFQPPNGAPQPGLGRRGAPGPPMGAGDLVQAALDG-GGRETASLGGAAGGAGQGPkaDFVPGDAES 447

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 269308222 551 ERRPLPPnnvTGKPGRAGIVSSSRVTSPPLKATLHPIGT 589
Cdd:COG5180  448 VSGPAGL---ADQAGAAASTAMADFVAPVTDATPVDVAD 483
KAR9 pfam08580
Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal ...
 274-565 8.64e-03

Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal protein required for karyogamy, correct positioning of the mitotic spindle and for orientation of cytoplasmic microtubules. KAR9 localizes at the shmoo tip in mating cells and at the tip of the growing bud in anaphase.


Pssm-ID: 430088 [Multi-domain]  Cd Length: 684  Bit Score: 39.81  E-value: 8.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  274 LIIPGLNESTVKLP-----TSIMLEISDALKAQLAKNetlaLPAESKTPEVEKLAGQPVTVTPESVSRSTKPTLSSALDT 348
Cdd:pfam08580 332 IIQKAFKDRLTVNGelarlFNDLVPKWDALNELISNI----GNPSTSVPLSIEKKDRVKDVLLEEPSNSKGQSLRDSLSS 407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  349 AETALAPRQTTSMPPKL---KTPHSRmPAKEPV--PKEPLHTTSKPKMPPSPEVADTTSAPLETR-----GIPLIPVISP 418
Cdd:pfam08580 408 IFEDKNMHDTEDSPATLvanKTPGSS-PPSSVImtPVNKGSKTPSSRRGSSFDFGSSSERVINSKlrresKLPQIASTLK 486

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269308222  419 RPSQeelqtameetdqstqelfTTKIPRTTELAKTTQAPHRLHTAPVRPRIPGRPHGRPALNKTTTRPDKTKPRGTSHKN 498
Cdd:pfam08580 487 QTKR------------------PSKIPRASPNHSGFLSTPSNTATSETPTPALRPPSRPQPPPPGNRPRWNASTNTNDLD 548

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 269308222  499 GVGTGTKQAPKPPSPGRNASvdSHATRKPGSVSGTRRP----PIPHRHSSTRPVSPERRPLPpnNVTGKPG 565
Cdd:pfam08580 549 VGHNFKPLTLTTPSPTPSRS--SRSSSTLPPVSPLSRDksrsPAPTCRSVSRASRRRASRKP--TRIGSPN 615
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH