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Conserved domains on  [gi|62078651|ref|NP_001013983|]
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actin-related protein T1 [Rattus norvegicus]

Protein Classification

actin family protein( domain architecture ID 12199243)

actin family protein has well-characterized cytoskeletal functions and has also been implicated in nuclear activities

CATH:  3.30.420.40
Gene Ontology:  GO:0031491|GO:0006338
SCOP:  3000092

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ASKHA_NBD_actin_Arp-T1-3 cd13397
nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar ...
10-367 0e+00

nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar proteins; The family includes actin and human actin-related proteins T1, T2, and T3. Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Arp-T1, encoded by ACTRT1/ARPT1 gene expressed in testis, negatively regulates the Hedgehog (SHH) signaling, binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Arp-T2 (also called actin-related protein M2; encoded by ACTRT2/ARPM2 gene expressed in testis and various other cell types) and Arp-T3 (also called actin-related protein M1; encoded by ACTRT3/ARPM1 gene expressed in all tested human tissues) play general roles in the organization of the cytoskeleton like other cytoplasmic actin-related proteins.


:

Pssm-ID: 466848 [Multi-domain]  Cd Length: 359  Bit Score: 574.52  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  10 PAVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIPSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEKL 89
Cdd:cd13397   1 PAVVIDNGSGLIKAGFAGEDLPRAVFPSVVGRPKYKAVMLGAGQKEVYVGDEAQEKRGVLTLSYPIEHGIVTNWDDMEKI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  90 WKDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVPI 169
Cdd:cd13397  81 WHHTFENELRVKPEEHPVLLTEAPLNPKQNREKMAEIMFETFGVPAFYVAIQAVLSLYSSGRTTGLVLDSGDGVTHTVPI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 170 YEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSWG-SKDSEKCYQRSLSEYKLPDGNT 248
Cdd:cd13397 161 YEGYALPHAVQRLDLAGRDLTEYLMKLLKERGHSFTTTAEREIVRDIKEKLCYVALDyEEELKKKSEELEKEYTLPDGQV 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 249 IQMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFEGTPI 328
Cdd:cd13397 241 IKIGSERFRCPEALFRPSLIGREAPGIHKLVYNSIMKCDIDIRKDLYSNIVLSGGSTMFPGLPERLQKELEALAPSSTKV 320
                       330       340       350
                ....*....|....*....|....*....|....*....
gi 62078651 329 KITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYG 367
Cdd:cd13397 321 KVIAPPERKYSVWIGGSILASLSTFKSMWITRAEYDEFG 359
 
Name Accession Description Interval E-value
ASKHA_NBD_actin_Arp-T1-3 cd13397
nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar ...
10-367 0e+00

nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar proteins; The family includes actin and human actin-related proteins T1, T2, and T3. Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Arp-T1, encoded by ACTRT1/ARPT1 gene expressed in testis, negatively regulates the Hedgehog (SHH) signaling, binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Arp-T2 (also called actin-related protein M2; encoded by ACTRT2/ARPM2 gene expressed in testis and various other cell types) and Arp-T3 (also called actin-related protein M1; encoded by ACTRT3/ARPM1 gene expressed in all tested human tissues) play general roles in the organization of the cytoskeleton like other cytoplasmic actin-related proteins.


Pssm-ID: 466848 [Multi-domain]  Cd Length: 359  Bit Score: 574.52  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  10 PAVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIPSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEKL 89
Cdd:cd13397   1 PAVVIDNGSGLIKAGFAGEDLPRAVFPSVVGRPKYKAVMLGAGQKEVYVGDEAQEKRGVLTLSYPIEHGIVTNWDDMEKI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  90 WKDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVPI 169
Cdd:cd13397  81 WHHTFENELRVKPEEHPVLLTEAPLNPKQNREKMAEIMFETFGVPAFYVAIQAVLSLYSSGRTTGLVLDSGDGVTHTVPI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 170 YEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSWG-SKDSEKCYQRSLSEYKLPDGNT 248
Cdd:cd13397 161 YEGYALPHAVQRLDLAGRDLTEYLMKLLKERGHSFTTTAEREIVRDIKEKLCYVALDyEEELKKKSEELEKEYTLPDGQV 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 249 IQMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFEGTPI 328
Cdd:cd13397 241 IKIGSERFRCPEALFRPSLIGREAPGIHKLVYNSIMKCDIDIRKDLYSNIVLSGGSTMFPGLPERLQKELEALAPSSTKV 320
                       330       340       350
                ....*....|....*....|....*....|....*....
gi 62078651 329 KITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYG 367
Cdd:cd13397 321 KVIAPPERKYSVWIGGSILASLSTFKSMWITRAEYDEFG 359
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
9-376 3.15e-142

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 408.57  E-value: 3.15e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651      9 NPAVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIpSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEK 88
Cdd:smart00268   1 VPAIVIDNGSGTIKAGFAGEDFPQVVFPSIVGRPKDGK-GMVGDAKDIFVGDEAQEKRGGLELKYPIENGIVENWDDMEK 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651     89 LWKDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVP 168
Cdd:smart00268  80 IWDYTFFNELRVEPEEHPVLLTEPPMNPKSNREKILEIMFETFNFPALYIAIQAVLSLYASGRTTGLVIDSGDGVTHVVP 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651    169 IYEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSWGS-KDSEKCYQRSLS-----EYK 242
Cdd:smart00268 160 VVDGYVLPHAIKRIDIAGRDITDYLKELLSERGYQFNSSAEFEIVREIKEKLCYVAEDFeKEMKLARESSESsklekTYE 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651    243 LPDGNTIQMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLA 322
Cdd:smart00268 240 LPDGNTIKVGNERFRIPEILFSPELIGLEQKGIHELVYESIQKCDIDVRKDLYENIVLSGGSTLIPGFGERLEKELKQLA 319
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 62078651    323 FEGTPIKITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYGAFVVQRKCF 376
Cdd:smart00268 320 PKKLKVKVIAPPERKYSVWLGGSILASLSTFEDMWITKKEYEESGSQIVERKCF 373
PTZ00004 PTZ00004
actin-2; Provisional
11-376 1.59e-134

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 389.13  E-value: 1.59e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   11 AVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIPSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEKLW 90
Cdd:PTZ00004   8 AAVVDNGSGMVKAGFAGDDAPRCVFPSIVGRPKNPGIMVGMEEKDCYVGDEAQDKRGILTLKYPIEHGIVTNWDDMEKIW 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   91 KDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVPIY 170
Cdd:PTZ00004  88 HHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETHNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  171 EGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSWG----SKDSEKCYQRSLSEYKLPDG 246
Cdd:PTZ00004 168 EGYSLPHAIHRLDVAGRDLTEYMMKILHERGTTFTTTAEKEIVRDIKEKLCYIALDfdeeMGNSAGSSDKYEESYELPDG 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  247 NTIQMSDHLCQVPEVLFTPEHLGIHD-LGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFEG 325
Cdd:PTZ00004 248 TIITVGSERFRCPEALFQPSLIGKEEpPGIHELTFQSINKCDIDIRKDLYGNIVLSGGTTMYRGLPERLTKELTTLAPST 327
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 62078651  326 TPIKITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYGAFVVQRKCF 376
Cdd:PTZ00004 328 MKIKVVAPPERKYSVWIGGSILSSLPTFQQMWVTKEEYDESGPSIVHRKCF 378
Actin pfam00022
Actin;
9-376 4.27e-132

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 383.96  E-value: 4.27e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651     9 NPAVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKfniPSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEK 88
Cdd:pfam00022   1 VSALVIDNGSHTTRAGFAGEDAPKAVIPSCVGKPR---GTKVEAANKYYVGDEALTYRPGMEVRSPVEDGIVVDWDAMEE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651    89 LWKDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVP 168
Cdd:pfam00022  78 IWEHVLKEELQVDPEEHPLLLTEPPWNPPANREKAAEIMFEKFGVPALYLAKNPVLSAFASGRTTGLVVDSGAGVTSVVP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   169 IYEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTF-PCILNKA-----------------------------VVDDIKE 218
Cdd:pfam00022 158 VHDGYVLQKAIRRSDLGGDFLTDYLRELLRSRNIEItPRYLIKSkkpgdpapavtkrelpdttysyktyqerrVLEEIKE 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   219 KLCTVSWGSKDSEKCYQRSL-SEYKLPDGNTIQMSDHLCQVPEVLFTPEHLGI--------HDLGISKMVCNSIMKCDTD 289
Cdd:pfam00022 238 SVCYVSDDPFGDETTSSSIPtRVYELPDGSTIILGAERFRVPEILFNPSLIGSeselpppqTAVGIPELIVDAINACDVD 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   290 IQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFEGTPIKITASP---DRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEY 366
Cdd:pfam00022 318 LRPSLLANIVVTGGNSLFPGFTERLEKELAQLAPPGVKVKIIAPGntvERRYSAWIGGSILASLGTFQQMWVSKQEYEEH 397
                         410
                  ....*....|
gi 62078651   367 GAFVVQRKCF 376
Cdd:pfam00022 398 GASVVERKCK 407
COG5277 COG5277
Actin-related protein [Cytoskeleton];
1-357 6.78e-65

Actin-related protein [Cytoskeleton];


Pssm-ID: 444088  Cd Length: 424  Bit Score: 212.34  E-value: 6.78e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   1 MLNTARLdNPAVIFDNGSGLCKVG-ISGEIVPRHVIN-----SVVGHPKFNIPSaRSNRKRYFVGEEAQCMYD-----GL 69
Cdd:COG5277   1 MSDAYKL-KYVIGIDFGTSYVKYGpIALEEKPRVIQTrglflRIVGESKLLGPM-EGLSRGLVVGDEVSKYLSsvrdaIR 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  70 YLHYPIERGLVTR-----WDDMEKLWKDLFEWELGVKPNEQPVFM--TEPSLNPRETREKTTEIMFEKF---NVPALYLC 139
Cdd:COG5277  79 NLKYPLRDGIVRRddedaWRVLKELLRYTFAQFLVVDPEFHGFLVvvALSALAPDYMRERLFDIHFEVFseeGAPAVTII 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 140 NHAVGALCASACITGLVLDSGDGVTCTVPIYEGySLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKaVVDDIKEK 219
Cdd:COG5277 159 PQPLAVAIAEKAVTCVVVEAGHGNSQVAPISRG-PIREGLVALNRGGAEANAITREILKDRGYSDTAREEY-VVRVVKEA 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 220 LCTV--------SWGSKDSEkcyqRSLSEYKLPDGNT-IQMSDHLCQ---VPEVLFTPEHLGIH---------------- 271
Cdd:COG5277 237 LGLVprdlakaiQKAASNPD----SFEAKVRLPNPTVeIELGNYAWErflIGEILFNPNHEGFEsyiqqgrlriedavig 312
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 272 ------DLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLF---PGLQD-------RLLKELEVLAFEgTPIKITASPD 335
Cdd:COG5277 313 dvvlygEMGLAEAIINSIMKCDVEIQDELYSNIILSGGAFNWsvpPGLEDvavdsvtRVQIELSELAPE-LKVNVRLVSD 391
                       410       420
                ....*....|....*....|..
gi 62078651 336 RCYSAWIGGSVMTSLTTFKQMW 357
Cdd:COG5277 392 PQYSVWKGAIIYGYALPFSVKW 413
syringactin NF040575
syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in ...
304-375 1.40e-15

syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in the plant pathogen Pseudomonas syringae and related species. This model was created, in part, to clarify that the family is real and distinct, rather than an artifact of eukaryotic contamination of bacterial genomic sequence data. As of the creation of this HMM, the family is uncharacterized.


Pssm-ID: 468549 [Multi-domain]  Cd Length: 132  Bit Score: 72.70  E-value: 1.40e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62078651  304 TTLFPGLQDRLLKELEVLAFEGTPIKITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYGAFVVQRKC 375
Cdd:NF040575  61 RVNESGFYEKLKKSITEKAPKGALIGMTLDPKPESAAWRGAAMYAASEGFVEMAITKQEYDESGPSIVHRKC 132
 
Name Accession Description Interval E-value
ASKHA_NBD_actin_Arp-T1-3 cd13397
nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar ...
10-367 0e+00

nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar proteins; The family includes actin and human actin-related proteins T1, T2, and T3. Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Arp-T1, encoded by ACTRT1/ARPT1 gene expressed in testis, negatively regulates the Hedgehog (SHH) signaling, binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Arp-T2 (also called actin-related protein M2; encoded by ACTRT2/ARPM2 gene expressed in testis and various other cell types) and Arp-T3 (also called actin-related protein M1; encoded by ACTRT3/ARPM1 gene expressed in all tested human tissues) play general roles in the organization of the cytoskeleton like other cytoplasmic actin-related proteins.


Pssm-ID: 466848 [Multi-domain]  Cd Length: 359  Bit Score: 574.52  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  10 PAVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIPSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEKL 89
Cdd:cd13397   1 PAVVIDNGSGLIKAGFAGEDLPRAVFPSVVGRPKYKAVMLGAGQKEVYVGDEAQEKRGVLTLSYPIEHGIVTNWDDMEKI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  90 WKDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVPI 169
Cdd:cd13397  81 WHHTFENELRVKPEEHPVLLTEAPLNPKQNREKMAEIMFETFGVPAFYVAIQAVLSLYSSGRTTGLVLDSGDGVTHTVPI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 170 YEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSWG-SKDSEKCYQRSLSEYKLPDGNT 248
Cdd:cd13397 161 YEGYALPHAVQRLDLAGRDLTEYLMKLLKERGHSFTTTAEREIVRDIKEKLCYVALDyEEELKKKSEELEKEYTLPDGQV 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 249 IQMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFEGTPI 328
Cdd:cd13397 241 IKIGSERFRCPEALFRPSLIGREAPGIHKLVYNSIMKCDIDIRKDLYSNIVLSGGSTMFPGLPERLQKELEALAPSSTKV 320
                       330       340       350
                ....*....|....*....|....*....|....*....
gi 62078651 329 KITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYG 367
Cdd:cd13397 321 KVIAPPERKYSVWIGGSILASLSTFKSMWITRAEYDEFG 359
ASKHA_NBD_actin cd10224
nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein ...
11-371 2.70e-150

nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Actin is a monomeric globular protein (G-actin) that reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. At low salt concentrations, actin exists as a monomer, and as the salt concentration rises F-actin forms, with the consequent hydrolysis of ATP. F-actin assembly is in constant flux with G-actin association occurring at the barbed end (+) and its disassociation at the pointed end (-). Actin monomers that have been released from the pointed end can be reused, if the ADP is exchanged for ATP. F-actin filaments can assemble into higher order structures, for example branched F-actin, and stress fibers. Actin binding proteins regulate actin filament dynamics by a range of functions including actin severing, depolymerizing, capping, stabilizing and de novo actin polymerization. Actins interaction with myosin is the basis of muscular contraction and many aspects of cell motility. In vertebrates there are three main groups of actin isoforms, alpha, beta and gamma. The alpha actins found in muscle tissues are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. In plants there are many isoforms which are probably involved in a variety of functions such as cytoplasmic streaming, cell shape determination, tip growth, graviperception, cell wall deposition, etc.


Pssm-ID: 466823  Cd Length: 365  Bit Score: 428.71  E-value: 2.70e-150
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  11 AVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIPSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEKLW 90
Cdd:cd10224   2 ALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIW 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  91 KDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVPIY 170
Cdd:cd10224  82 HHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 171 EGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSWGSKDSEKCYQRSLS---EYKLPDGN 247
Cdd:cd10224 162 EGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMQTAASSSSlekSYELPDGQ 241
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 248 TIQMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFEGTP 327
Cdd:cd10224 242 VITIGNERFRCPEALFQPSFLGMEAAGIHETTYNSIMKCDVDIRKDLYANIVLSGGTTMFPGIADRMQKEITALAPSTMK 321
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 62078651 328 IKITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYGAFVV 371
Cdd:cd10224 322 IKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIV 365
ASKHA_NBD_Arp1 cd10216
nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, ...
9-375 8.11e-144

nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, also called centractin, actin-like protein, alpha-centractin, actin-RPV, or centrosome-associated actin homolog, may be a component of a multi-subunit centrosomal complex involved in microtubule-based vesicle motility. In yeast, actin-related protein is essential for viability and is associated with the centrosome. In vertebrates, Arp1 is a core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. ARP1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. It is required for proper orientation of the mitotic spindle. Arp1 is the only actin-related protein known to form actin-like filaments. Human Arp1/centractin is encoded by the ACTR1A gene.


Pssm-ID: 466820 [Multi-domain]  Cd Length: 370  Bit Score: 412.32  E-value: 8.11e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   9 NPAVIfDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIPSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEK 88
Cdd:cd10216   2 QPVVI-DNGSGVIKAGFAGDDIPKVVFPSYVGRPKHVRVMAGALEGDVFVGPKAEEHRGLLKIRYPMEHGIVTDWNDMER 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  89 LWKDLFEWE-LGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTV 167
Cdd:cd10216  81 IWQYVYSKLqLNTFSEEHPVLLTEAPLNPRKNREKAAEVFFETFNVPALFVSMQAVLSLYASGRTTGVVLDSGDGVTHAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 168 PIYEGYSLPRAITKLYVAGRDITEHLtRLLLAK-GYTFPCILNKAVVDDIKEKLCTVSWGSKDSEKCYQRS--LSEYKLP 244
Cdd:cd10216 161 PIYEGFALPHSIRRVDIAGRDVTEYL-QLLLRKsGYNFHTSAEFEIVREIKEKACYVALNPQKEEKLEEEKteKAQYTLP 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 245 DGNTIQMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFE 324
Cdd:cd10216 240 DGSTIEIGPERFRAPEILFNPELIGLEYPGVHEVLVDSIQKSDLDLRKTLYSNIVLSGGSTLFKGFGDRLLSEVKKLAPK 319
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 62078651 325 GTPIKITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYGAFVVQRKC 375
Cdd:cd10216 320 DVKIRISAPPERLYSTWIGGSILASLSTFKKMWVSKKEYEEDGARILHRKT 370
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
9-376 3.15e-142

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 408.57  E-value: 3.15e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651      9 NPAVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIpSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEK 88
Cdd:smart00268   1 VPAIVIDNGSGTIKAGFAGEDFPQVVFPSIVGRPKDGK-GMVGDAKDIFVGDEAQEKRGGLELKYPIENGIVENWDDMEK 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651     89 LWKDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVP 168
Cdd:smart00268  80 IWDYTFFNELRVEPEEHPVLLTEPPMNPKSNREKILEIMFETFNFPALYIAIQAVLSLYASGRTTGLVIDSGDGVTHVVP 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651    169 IYEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSWGS-KDSEKCYQRSLS-----EYK 242
Cdd:smart00268 160 VVDGYVLPHAIKRIDIAGRDITDYLKELLSERGYQFNSSAEFEIVREIKEKLCYVAEDFeKEMKLARESSESsklekTYE 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651    243 LPDGNTIQMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLA 322
Cdd:smart00268 240 LPDGNTIKVGNERFRIPEILFSPELIGLEQKGIHELVYESIQKCDIDVRKDLYENIVLSGGSTLIPGFGERLEKELKQLA 319
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 62078651    323 FEGTPIKITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYGAFVVQRKCF 376
Cdd:smart00268 320 PKKLKVKVIAPPERKYSVWLGGSILASLSTFEDMWITKKEYEESGSQIVERKCF 373
PTZ00004 PTZ00004
actin-2; Provisional
11-376 1.59e-134

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 389.13  E-value: 1.59e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   11 AVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIPSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEKLW 90
Cdd:PTZ00004   8 AAVVDNGSGMVKAGFAGDDAPRCVFPSIVGRPKNPGIMVGMEEKDCYVGDEAQDKRGILTLKYPIEHGIVTNWDDMEKIW 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   91 KDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVPIY 170
Cdd:PTZ00004  88 HHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETHNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  171 EGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSWG----SKDSEKCYQRSLSEYKLPDG 246
Cdd:PTZ00004 168 EGYSLPHAIHRLDVAGRDLTEYMMKILHERGTTFTTTAEKEIVRDIKEKLCYIALDfdeeMGNSAGSSDKYEESYELPDG 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  247 NTIQMSDHLCQVPEVLFTPEHLGIHD-LGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFEG 325
Cdd:PTZ00004 248 TIITVGSERFRCPEALFQPSLIGKEEpPGIHELTFQSINKCDIDIRKDLYGNIVLSGGTTMYRGLPERLTKELTTLAPST 327
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 62078651  326 TPIKITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYGAFVVQRKCF 376
Cdd:PTZ00004 328 MKIKVVAPPERKYSVWIGGSILSSLPTFQQMWVTKEEYDESGPSIVHRKCF 378
PTZ00281 PTZ00281
actin; Provisional
8-376 4.36e-133

actin; Provisional


Pssm-ID: 173506 [Multi-domain]  Cd Length: 376  Bit Score: 385.59  E-value: 4.36e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651    8 DNPAVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIPSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDME 87
Cdd:PTZ00281   5 DVQALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDME 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   88 KLWKDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTV 167
Cdd:PTZ00281  85 KIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVSHTV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  168 PIYEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSWgskDSEKCYQRSLS------EY 241
Cdd:PTZ00281 165 PIYEGYALPHAILRLDLAGRDLTDYMMKILTERGYSFTTTAEREIVRDIKEKLAYVAL---DFEAEMQTAASssalekSY 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  242 KLPDGNTIQMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVL 321
Cdd:PTZ00281 242 ELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYGNVVLSGGTTMFPGIADRMNKELTAL 321
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 62078651  322 AFEGTPIKITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYGAFVVQRKCF 376
Cdd:PTZ00281 322 APSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPSIVHRKCF 376
Actin pfam00022
Actin;
9-376 4.27e-132

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 383.96  E-value: 4.27e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651     9 NPAVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKfniPSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEK 88
Cdd:pfam00022   1 VSALVIDNGSHTTRAGFAGEDAPKAVIPSCVGKPR---GTKVEAANKYYVGDEALTYRPGMEVRSPVEDGIVVDWDAMEE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651    89 LWKDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVP 168
Cdd:pfam00022  78 IWEHVLKEELQVDPEEHPLLLTEPPWNPPANREKAAEIMFEKFGVPALYLAKNPVLSAFASGRTTGLVVDSGAGVTSVVP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   169 IYEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTF-PCILNKA-----------------------------VVDDIKE 218
Cdd:pfam00022 158 VHDGYVLQKAIRRSDLGGDFLTDYLRELLRSRNIEItPRYLIKSkkpgdpapavtkrelpdttysyktyqerrVLEEIKE 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   219 KLCTVSWGSKDSEKCYQRSL-SEYKLPDGNTIQMSDHLCQVPEVLFTPEHLGI--------HDLGISKMVCNSIMKCDTD 289
Cdd:pfam00022 238 SVCYVSDDPFGDETTSSSIPtRVYELPDGSTIILGAERFRVPEILFNPSLIGSeselpppqTAVGIPELIVDAINACDVD 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   290 IQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFEGTPIKITASP---DRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEY 366
Cdd:pfam00022 318 LRPSLLANIVVTGGNSLFPGFTERLEKELAQLAPPGVKVKIIAPGntvERRYSAWIGGSILASLGTFQQMWVSKQEYEEH 397
                         410
                  ....*....|
gi 62078651   367 GAFVVQRKCF 376
Cdd:pfam00022 398 GASVVERKCK 407
PTZ00466 PTZ00466
actin-like protein; Provisional
9-376 9.90e-116

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 341.54  E-value: 9.90e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651    9 NPAVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIPSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEK 88
Cdd:PTZ00466  12 NQPIIIDNGTGYIKAGFAGEDVPNLVFPSYVGRPKYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINHGIIENWNDMEN 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   89 LWKDLFEwELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVP 168
Cdd:PTZ00466  92 IWIHVYN-SMKINSEEHPVLLTEAPLNPQKNKEKIAEVFFETFNVPALFISIQAILSLYSCGKTNGTVLDCGDGVCHCVS 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  169 IYEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSWGSKDSEKCYQRSLS--EYKLPDG 246
Cdd:PTZ00466 171 IYEGYSITNTITRTDVAGRDITTYLGYLLRKNGHLFNTSAEMEVVKNMKENCCYVSFNMNKEKNSSEKALTtlPYILPDG 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  247 NTIQMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFEGT 326
Cdd:PTZ00466 251 SQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRRTLYSHIVLSGGTTMFHGFGDRLLNEIRKFAPKDI 330
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 62078651  327 PIKITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYGAFVVQRKCF 376
Cdd:PTZ00466 331 TIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHRKTF 380
ASKHA_NBD_actin-like cd10169
nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ...
12-367 1.45e-115

nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ubiquitous in eukaryotes, and the major component of the actin cytoskeleton; monomeric globular protein (G-actin) reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. F-actin filaments form with the consequent hydrolysis of ATP. Some actin-related proteins (Arps) have roles in cytoskeletal functions, such as actin polymerization (Arp2/3) and dynein motor activity (Arp1). Both conventional actin and specific Arps have been implicated in chromatin remodeling and/or transcription regulation. The actin/ARP family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466810 [Multi-domain]  Cd Length: 258  Bit Score: 336.39  E-value: 1.45e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  12 VIFDNGSGLCKVGISGEIVPRHVInsvvghpkfnipsarsnrkryfvgeeaqcmydglylhypierglvtRWDDMEKLWK 91
Cdd:cd10169   1 IVIDNGSGTIKAGFAGEDAPRLIF----------------------------------------------PWDDMEKIWE 34
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  92 DLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVPIYE 171
Cdd:cd10169  35 HVFYNLLRVDPEEHPVLLTEPPLNPKANREKLAEILFETFNVPSLYIANQAVLSLYASGRTTGLVVDSGEGVTHIVPVYE 114
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 172 GYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCtvswgskdsekcyqrslseyklpdgntiqm 251
Cdd:cd10169 115 GYVLPHAVRRLDIGGRDLTDYLAKLLREKGYSFSTSAEREIVRDIKEKLC------------------------------ 164
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 252 sdhlcqvpevlftpehlgihdlGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFEGTPIKIT 331
Cdd:cd10169 165 ----------------------GLHELIYDSIMKCDIDLRKELYSNIVLSGGTTLFPGFAERLQKELSKLAPSSVKVKVI 222
                       330       340       350
                ....*....|....*....|....*....|....*.
gi 62078651 332 ASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYG 367
Cdd:cd10169 223 APPERKYSAWIGGSILASLSTFQQMWITKEEYEEHG 258
PTZ00452 PTZ00452
actin; Provisional
10-376 4.20e-114

actin; Provisional


Pssm-ID: 185631  Cd Length: 375  Bit Score: 337.11  E-value: 4.20e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   10 PAVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIPSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEKL 89
Cdd:PTZ00452   6 PAVVIDNGSGYCKIGIAGDDAPTSCFPAIVGRSKQNDGIFSTFNKEYYVGEEAQAKRGVLAIKEPIQNGIINSWDDIEII 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   90 WKDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVPI 169
Cdd:PTZ00452  86 WHHAFYNELCMSPEDQPVFMTDAPMNSKFNRERMTQIMFETFNTPCLYISNEAVLSLYTSGKTIGLVVDSGEGVTHCVPV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  170 YEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSWGSKDSEKCYQRSLSE---YKLPDG 246
Cdd:PTZ00452 166 FEGHQIPQAITKINLAGRLCTDYLTQILQELGYSLTEPHQRIIVKNIKERLCYTALDPQDEKRIYKESNSQdspYKLPDG 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  247 NTIQMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFEGT 326
Cdd:PTZ00452 246 NILTIKSQKFRCSEILFQPKLIGLEVAGIHHLAYSSIKKCDLDLRQELCRNIVLSGGTTLFPGIANRLSNELTNLVPSQL 325
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 62078651  327 PIKITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYGAFVVQRKCF 376
Cdd:PTZ00452 326 KIQVAAPPDRRFSAWIGGSIQCTLSTQQPQWIKRQEYDEQGPSIVHRKCF 375
ASKHA_NBD_ACTL7 cd10214
nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ...
11-375 4.09e-107

nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ACTL7-like family includes ACTL7A, ACTL7B and ACTL9 (also known as ACTL7C). In mammalian, ACTL7A is expressed in a wide variety of adult tissues, while the ACTL7B is expressed in spermatids through the elongation phase of spermatid development. ACTL7A, also called actin-like-7-alpha, or T-ACTIN-2 in mouse, may play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis. ACTL7B, also called actin-like-7-beta, acts as a key regulator of spermiogenesis that is required for male fertility. ACTL9 is a testis-specific protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.


Pssm-ID: 466819 [Multi-domain]  Cd Length: 368  Bit Score: 318.98  E-value: 4.09e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  11 AVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIPSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEKLW 90
Cdd:cd10214   5 AVIIDLGTGYCKAGFAGQPRPSYVISSTVGKPPQESAKTGDNRKETFVGKELANVEPPLKLVNPLRHGIVVDWDCVQDIW 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  91 KDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVPIY 170
Cdd:cd10214  85 EYIFEKEMKILPEEHAVLVSDPPLSPTTNREKYAELMFETFSIPAMHIAYQSRLSLYSYGRTSGLVVESGHGVSYVVPIH 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 171 EGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPcILNKAVVDDIKEKLCTVSWgskDSEKCYQRSLSE----YKLPDG 246
Cdd:cd10214 165 EGYNLPHITGRADYAGSDLTAYLMKLLNEAGNKFT-DDQLHIVEDIKKKCCYVAL---DFEEEMGLPPQEytvdYELPDG 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 247 NTIQMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFEGT 326
Cdd:cd10214 241 HLITIGKERFRCPEMLFNPSLIGSKQPGLHTLTMNSLNKCDANLKKDLAKNILLCGGSTMFDGFPDRFQKELSKLCPNDN 320
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....
gi 62078651 327 PIkITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYGAFVVQRKC 375
Cdd:cd10214 321 PI-VAASPERKYSVWTGGSILASLKSFQQLWVRRREYEERGPFVIYRKC 368
ASKHA_NBD_Arp2 cd10220
nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, ...
12-373 5.99e-106

nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, also called actin-like protein 2, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp2 is encoded by the ACTR2 gene.


Pssm-ID: 466821  Cd Length: 381  Bit Score: 316.43  E-value: 5.99e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  12 VIFDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIPSARSNR--KRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEKL 89
Cdd:cd10220   3 VVCDNGTGFVKCGFAGSNFPEHVFPSLVGRPILRAEEKVGDIeiKDIMVGDEASELRSMLEVTYPMENGIVRNWDDMEHL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  90 WKDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVPI 169
Cdd:cd10220  83 WDYTFGEKLKIDPRECKILLTEPPMNPTKNREKMVEVMFEKYGFAGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHIVPV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 170 YEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFpcilNKA----VVDDIKEKLCTVSWGSKDSEK------CYQRSls 239
Cdd:cd10220 163 YEGFSLPHLTRRLDVAGRDITRYLIKLLLLRGYAF----NRTadfeTVREIKEKLCYVAYDIELEQKlalettVLVES-- 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 240 eYKLPDGNTIQMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELE 319
Cdd:cd10220 237 -YTLPDGRVIKVGGERFEAPEALFQPHLIDVEGPGIAELLFNTIQAADIDTRPELYKHIVLSGGSTMYPGLPSRLEKEIK 315
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62078651 320 VLAFE----GTP-------IKITASPDRCYSAWIGGSVMTSLTTFK-QMWVTAEDFKEYGAFVVQR 373
Cdd:cd10220 316 QLYLErvlkGDTerlskfkIRIEDPPRRKHMVFLGGAVLADIMKDKdEFWITRQEYEEQGVRVLDK 381
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
10-367 2.19e-104

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 313.73  E-value: 2.19e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  10 PAVIFDNGSGLCKVGISGEIVPRHVINSVVG----HPKFNIPSARS--NRKRYFVGEEAQCMY-DGLYLHYPIERGLVTR 82
Cdd:cd13395   5 GALVLDIGSYSTRAGYAGEDTPKAVFPSVVGvvtdDDDAEDYVGGSgeKKRKYYIGTNSIGVPrPNMEVISPLKDGLIED 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  83 WDDMEKLWKDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDG 162
Cdd:cd13395  85 WDAFEKLWDHALKNRLRVDPSEHPLLLTEPSWNTRANREKLTELMFEKYNVPAFFLAKNAVLSAFANGRSTALVVDSGAT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 163 VTCTVPIYEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTF-----------------PCILNK--------------- 210
Cdd:cd13395 165 STSVVPVHDGYVLQKAIVRSPLGGDFLTDQLLKLLESKNIEIiprymikskepveggapAKYTKKdlpnttssyhrymvr 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 211 AVVDDIKEKLCTVSWGSKDSEKCYQRSLSEYKLPDGNTIQMSDHLCQVPEVLFTP---------EHLGIHDLGISKMVCN 281
Cdd:cd13395 245 RVLQDFKESVCQVSDSPFDESEAASIPTVSYELPDGYNIEFGAERFKIPELLFDPslvkgipapPSEGNELLGLPQLVYT 324
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 282 SIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFEGTPIKITASP---DRCYSAWIGGSVMTSLTTFKQMWV 358
Cdd:cd13395 325 SIGSCDVDIRPELYGNVVLTGGNSLLPGFTDRLNRELSEKAPGSLKLKILASGntvERRFSSWIGGSILASLGSFQQMWI 404

                ....*....
gi 62078651 359 TAEDFKEYG 367
Cdd:cd13395 405 SKQEYEEHG 413
ASKHA_NBD_Arp6 cd10210
nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, ...
12-367 1.78e-75

nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, also called actin-like protein 6, is required for formation and/or maintenance of proper nucleolar structure and function, plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, Arp6 maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, it is required for the repression of rDNA transcription, and this function may be independent of H2A.Z. Arp6 is also required for telomere silencing in both fission and budding yeast. It is a component of the budding yeast and Arabidopsis SWR1 complex (SWR1C) and the human SWI2/SNF2-related CBP activator protein (SRCAP) chromatin remodeling complexes which catalyze the exchange of the histone H2A with the H2AZ. Drosophila Arp6 colocalizes with HP1 (heterochromatin protein 1) in the pericentric heterochromatin, and vertebrate Arp6 also interacts with HP1. Human Arp6 is encoded by the ACTR6 gene. Arabidopsis thaliana ACTIN RELATED PROTEIN 6/EARLY IN SHORT DAYS 1/SUPPRESSOR OF FRIGIDA 3 (encoded by ARP6/ESD1/SUF3) participates in regulating several leaf and flower development stages. It is needed for Flowering locus C (FLC, the master repressor of flowering) and FLC-like gene expression in the shoot and root apex, and for the activity of the floral repressor pathway.


Pssm-ID: 466816 [Multi-domain]  Cd Length: 389  Bit Score: 238.60  E-value: 1.78e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  12 VIFDNGSGLCKVGISGEiVPRHVINSVVGHPKfnipsarSNRKRYFVGEEAQCMYD--GLYLHYPIERGLVTRWDDMEKL 89
Cdd:cd10210   2 LVLDNGAYTIKAGFASD-DPPRVIPNCIAKPK-------SERRRLFGDDQLDECKDlsGLFYRRPFERGYLVNWDLQRQI 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  90 WKDLFE-WELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNhaVGALCA--------------SACitG 154
Cdd:cd10210  74 WDHLFGkLLLNVDPSDTALVLTEPPFNPPSIQEAMDEIVFEEYGFQSLYRTT--AAALSAfayladseqsssssSQC--C 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 155 LVLDSGDGVTCTVPIYEGYSLPRAITKLYVAGRDITEHLT-----RLLLAKGYTFpcilnkaVVDDIKEKLCTVS---Wg 226
Cdd:cd10210 150 LVVDSGFSFTHIVPFFDGKPVKRAVRRIDVGGKLLTNYLKeiisyRQLNVMDETY-------LVNQIKEDLCFVStdfY- 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 227 sKDSEKCYQRSLS-----EYKLPDGNTIQ-----------------------MSDHLCQVPEVLFTPEHLGIHDLGISKM 278
Cdd:cd10210 222 -EDLEIAKKKGKEntirrDYVLPDYTTSKrgyvrdpeepnrgklkedeqvlrLNNERFTVPELLFHPSDIGIQQAGIAEA 300
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 279 VCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVLAFEGTPIKITASPDRCYSAWIGGSVMTSLTTFKQMWV 358
Cdd:cd10210 301 IVQSINACPEELQPLLYANIVLTGGNALFPGFRERLEAELRSLAPDDYDVNVTLPEDPITYAWEGGSLLAQSPEFEELAV 380

                ....*....
gi 62078651 359 TAEDFKEYG 367
Cdd:cd10210 381 TRAEYEEHG 389
PTZ00280 PTZ00280
Actin-related protein 3; Provisional
9-373 8.61e-74

Actin-related protein 3; Provisional


Pssm-ID: 240343 [Multi-domain]  Cd Length: 414  Bit Score: 235.01  E-value: 8.61e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651    9 NPAVIFDNGSGLCKVGISGEIVPRHVINSVVG-HPKFNIPSARSNRKR--YFVGEEAQCMYDGLYLHYPIERGLVTRWDD 85
Cdd:PTZ00280   4 LPVVVIDNGTGYTKMGYAGNTEPTYIIPTLIAdNSKQSRRRSKKGFEDldFYIGDEALAASKSYTLTYPMKHGIVEDWDL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   86 MEKLWKDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCAS----------ACITGL 155
Cdd:PTZ00280  84 MEKFWEQCIFKYLRCEPEEHYFILTEPPMNPPENREYTAEIMFETFNVKGLYIAVQAVLALRASwtskkakelgGTLTGT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  156 VLDSGDGVTCTVPIYEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSWG-SKDSEKcY 234
Cdd:PTZ00280 164 VIDSGDGVTHVIPVVDGYVIGSSIKHIPLAGRDITNFIQQMLRERGEPIPAEDILLLAQRIKEKYCYVAPDiAKEFEK-Y 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  235 QRSLSEY--KLPDGNTIQMSDHLCQV-------PEVLFTPEHL-GIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGT 304
Cdd:PTZ00280 243 DSDPKNHfkKYTAVNSVTKKPYTVDVgyerflgPEMFFHPEIFsSEWTTPLPEVVDDAIQSCPIDCRRPLYKNIVLSGGS 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  305 TLFPGLQDRLLKELEVLA--------------FEGTPIK--ITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYGA 368
Cdd:PTZ00280 323 TMFKGFDKRLQRDVRKRVdrrlkkaeelsggkLKPIPIDvnVVSHPRQRYAVWYGGSMLASSPEFEKVCHTKAEYDEYGP 402

                 ....*
gi 62078651  369 FVVQR 373
Cdd:PTZ00280 403 SICRY 407
ASKHA_NBD_Arp3-like cd10221
nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, ...
11-373 8.93e-73

nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, also called actin-like protein 3, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp3 and Arp3B are encoded by the ACTR3 and ACTR3B genes respectively. Arp3B is also known as actin-related protein Arp4.


Pssm-ID: 466822  Cd Length: 404  Bit Score: 232.07  E-value: 8.93e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  11 AVIFDNGSGLCKVGISGEIVPRHVINSVVG-HPKFNIPSARSNRKR------YFVGEEAQCMYDGLYLHYPIERGLVTRW 83
Cdd:cd10221   1 AVVIDNGTGYTKMGYAGNTEPQFIIPTVIAiKESAKVGDGQRRSKKgiedldFYIGDEALANSPTYALKYPIRHGIVEDW 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  84 DDMEKLWKDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCAS--------ACITGL 155
Cdd:cd10221  81 DLMERFWEQCIFKYLRCEPEDHYFLLTEPPLNPPENREYTAEIMFETFNVPGLYIAVQAVLALAASwtsrkvgeRTLTGT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 156 VLDSGDGVTCTVPIYEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSWG-SKDSEKcY 234
Cdd:cd10221 161 VIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREEGIPPEDSLEVAKRIKERYCYVCPDiVKEFAK-Y 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 235 QRSLSEY--KLPDGNTIQMSDHLCQV-------PEVLFTPEHLGI-HDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGT 304
Cdd:cd10221 240 DSDPAKYikQYTGINSVTGKPYTVDVgyerflaPEIFFNPEIASSdFTTPLPEVVDQVIQSCPIDTRRGLYKNIVLSGGS 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 305 TLFPGLQDRL-----------LKELEVLAfeGTPIK--------ITASPDRcYSAWIGGSVMTSLTTFKQMWVTAEDFKE 365
Cdd:cd10221 320 TMFKDFGRRLqrdvkrivdarLKASEELS--GGKLKpkpidvnvISHPMQR-YAVWFGGSMLASTPEFYTVCHTKAEYEE 396

                ....*...
gi 62078651 366 YGAFVVQR 373
Cdd:cd10221 397 YGPSICRH 404
COG5277 COG5277
Actin-related protein [Cytoskeleton];
1-357 6.78e-65

Actin-related protein [Cytoskeleton];


Pssm-ID: 444088  Cd Length: 424  Bit Score: 212.34  E-value: 6.78e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   1 MLNTARLdNPAVIFDNGSGLCKVG-ISGEIVPRHVIN-----SVVGHPKFNIPSaRSNRKRYFVGEEAQCMYD-----GL 69
Cdd:COG5277   1 MSDAYKL-KYVIGIDFGTSYVKYGpIALEEKPRVIQTrglflRIVGESKLLGPM-EGLSRGLVVGDEVSKYLSsvrdaIR 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  70 YLHYPIERGLVTR-----WDDMEKLWKDLFEWELGVKPNEQPVFM--TEPSLNPRETREKTTEIMFEKF---NVPALYLC 139
Cdd:COG5277  79 NLKYPLRDGIVRRddedaWRVLKELLRYTFAQFLVVDPEFHGFLVvvALSALAPDYMRERLFDIHFEVFseeGAPAVTII 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 140 NHAVGALCASACITGLVLDSGDGVTCTVPIYEGySLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKaVVDDIKEK 219
Cdd:COG5277 159 PQPLAVAIAEKAVTCVVVEAGHGNSQVAPISRG-PIREGLVALNRGGAEANAITREILKDRGYSDTAREEY-VVRVVKEA 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 220 LCTV--------SWGSKDSEkcyqRSLSEYKLPDGNT-IQMSDHLCQ---VPEVLFTPEHLGIH---------------- 271
Cdd:COG5277 237 LGLVprdlakaiQKAASNPD----SFEAKVRLPNPTVeIELGNYAWErflIGEILFNPNHEGFEsyiqqgrlriedavig 312
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 272 ------DLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLF---PGLQD-------RLLKELEVLAFEgTPIKITASPD 335
Cdd:COG5277 313 dvvlygEMGLAEAIINSIMKCDVEIQDELYSNIILSGGAFNWsvpPGLEDvavdsvtRVQIELSELAPE-LKVNVRLVSD 391
                       410       420
                ....*....|....*....|..
gi 62078651 336 RCYSAWIGGSVMTSLTTFKQMW 357
Cdd:COG5277 392 PQYSVWKGAIIYGYALPFSVKW 413
ASKHA_NBD_AtARP7-like cd10209
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar ...
74-371 1.78e-55

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar proteins; Arabidopsis thaliana ARP7 is an essential nuclear protein, ubiquitously expressed in all cell types. It is needed for normal embryogenesis, plant architecture, and floral organ abscission. It may play a role in regulating various phases of plant development through chromatin-mediated gene regulation.


Pssm-ID: 466815 [Multi-domain]  Cd Length: 354  Bit Score: 185.67  E-value: 1.78e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  74 PIERGLVTRWDDMEKLWKDLF----EWELGvkpNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCAS 149
Cdd:cd10209  50 PIRRGRIEDWDALEALLRYVFytglGWEEG---NEGQVLIAEPLLTSKAERERLTQLMFETFNVSGLYASEQAVLSLYAV 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 150 ACITGLVLDSGDGVTCTVPIYEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPciLNKAVVDDIKEKlctVSWGSKD 229
Cdd:cd10209 127 GRISGCVVDVGHGKIDIAPVWEGAIQHNAVRRFEIGGRDLTELLAAELGKSNPKVK--LDRSIVERLKEA---VAWSADD 201
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 230 SE----KCYQRSLSEYKLPDGNTIQMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTT 305
Cdd:cd10209 202 EEayekKVLTCSPETYTLPDGRVISVGKERYCVGEALFRPSILGIEEYGIVEQLVRAVSTSPSENRRQLLENIVLCGGTS 281
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62078651 306 LFPGLQDRLLKELEVLAfegTPIKITA-------SPDRC--YSAWIGGSVMTSLTTFKQMWVTAEDFKEYGAFVV 371
Cdd:cd10209 282 SVPGLEARLQKEIRLLS---SPSSRPAlvkppeyMPENTlrYSAWIGGAILAKVVFPQNQHVTKADYDETGPSVV 353
ASKHA_NBD_Arp5 cd10211
nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, ...
11-368 1.68e-50

nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, also called actin-like protein 5, may act as a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. It is involved in DNA double-strand break repair and UV-damage excision repair. Human Arp5 is encoded by the ACTR5 gene. Arabidopsis thaliana ARP5 (AtARp5) is a ubiquitously expressed nuclear protein involved in DNA repair and required for multicellular development of all organs. AtARp5 may be part of other chromatin remodeling machines in addition to INO80.


Pssm-ID: 466817 [Multi-domain]  Cd Length: 345  Bit Score: 172.37  E-value: 1.68e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  11 AVIFDNGSGLCKVGISGEIVPRHVINSVVGHPKfnipSARSNRKRYFVGEEAQCMyDGLYLHY--PIERGLVTRWDDMEK 88
Cdd:cd10211   1 PIVIDNGSYQCRAGWAGDKEPRLVFRNLVAKPR----DRKKGITVTLVGNDILND-EAVRSHLrsPFDRNVVTNFDLQEQ 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  89 LWKDLFEwELGVKPN---EQPVFMTEPSLNPRETREKTTEIMFEKFNVP-------ALYLCNHAVGALCASaciTGLVLD 158
Cdd:cd10211  76 ILDYIFS-HLGINSEgsvDHPIVLTEALCNPNYSRQLMSELLFECYGVPsvaygidSLFSYYHNQPQGDPS---DGLVIS 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 159 SGDGVTCTVPIYEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVswgSKDsekcYQRSL 238
Cdd:cd10211 152 SGYSTTHVIPVLNGRLDLSQCKRINLGGFHATDYLQRLLQLKYPTHPSAITLSRAEELVHEHCYV---AED----YDEEL 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 239 SEYKLPDgnTIQMSDHLCQVPevlftpehlgihdLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKEL 318
Cdd:cd10211 225 KKWEDPE--YYEENVRKIQLP-------------FGLVETIEFVLKRYPAEQQDRLVQNVFLTGGNALFPGLKERLEKEL 289
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 62078651 319 -EVLAFeGTPIKITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYGA 368
Cdd:cd10211 290 rAIRPF-GSPFNVVRAKDPVLDAWRGAAKWALDSTFEKVWITKQEYEEKGG 339
ASKHA_NBD_Arp10 cd10207
nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; ...
12-367 3.79e-43

nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; Arp10, also known as actin-related protein 11 (Arp11), is a subunit of the cargo-binding portion of the dynein activator, dynactin. It, together with dynactin4 (p62), -5(p25), and -6(p27), forms a heterotetrameric complex located at the pointed end of Arp1. Arp1 forms a mini-filament of uniform size, with proteins bound along its length and at both ends. Human Arp10 is encoded by the ACTR10 gene.


Pssm-ID: 466813 [Multi-domain]  Cd Length: 375  Bit Score: 153.95  E-value: 3.79e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  12 VIFDNGSGLCKVGISGEIVPRHVINSVVGHPKFNIPSaRSNRKRYFVGEEaqcmydglylhypierglvtrWDDM-EKLW 90
Cdd:cd10207   1 VVLDIGSAYTKCGFAGESAPRCIIPSEVKLPGGKKVI-RVVDQRSGNEEE---------------------LYEAlKEFL 58
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  91 KDLFEWELGVKPNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVPIY 170
Cdd:cd10207  59 HELYFKHLLVNPKDRRVVVVESVLCPTPFRETLAKVLFKHFEVPSVLFAPSHLLSLLTLGIRTALVVDCGYRETRVLPVY 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 171 EGYSLPRAITKLYVAGRDITEHLTRLLL---------AKGYTFPCI---LNKAVVDDIKEKLCTVSwgSKDSEKCYQRSL 238
Cdd:cd10207 139 EGVPLLSAWQSTPLGGKALHKRLKKLLLehatvvtgdNKGQLLSSVdslLSEEVLEDIKVRACFVT--SLERGKTLQSAT 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 239 SE-------------YKLPDGNTIQM-SDHLCQVPEVLFTPEhlgIHDLGISKMVCNSIMKCDTDIQENLFAEIVLSGGT 304
Cdd:cd10207 217 EEgsteepsppppvdYPLDGEKILIVpGSIRESAEELLFEGD---NEEKSLPTLILDSLLKCPIDVRKQLAENIVVIGGT 293
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62078651 305 TLFPGLQDRLLKELEVL--------AFEGTPIKITASPDRC---YSAWIGGSVMTSLTTFKQMWVTAEDFKEYG 367
Cdd:cd10207 294 SMLPGFKHRLLEELRALlrkpkyfeELAPKTFRFHTPPSVFkpnYLAWLGGSIFGALESILGRSLSREAYLQTG 367
ASKHA_NBD_ScArp9-like cd10208
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and ...
73-371 6.77e-35

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and similar proteins; Saccharomyces cerevisiae Arp9, also called actin-like protein 9, chromatin structure-remodeling complex protein ARP9, or SWI/SNF complex component ARP9, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp9 forms a stable heterodimer with Arp7 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466814  Cd Length: 356  Bit Score: 131.28  E-value: 6.77e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  73 YPIERGLVTRWDDMEKLWKDLFEWELGVK--PNEQPVFMTEPSLNPRETREKTTEIMFEKFNVPALYLCNHAVGALCASA 150
Cdd:cd10208  37 WPIQDGRVVDWDALEALWRHILFSLLSIPrpTNNSPVLLSVPPSWSKSDLELLTQLFFERLNVPAFAILEAPLAALYAAG 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 151 CITGLVLDSGDGVTCTVPIYEGYSLPRAITKLYVAGRDITEHLTRLLLAKGYTFPC--ILNKAVVDDIKEKLctvswgsK 228
Cdd:cd10208 117 ATSGIVVDIGHEKTDITPIVDSQVVPHALVSIPIGGQDCTAHLAQLLKSDEPELKSqaESGEEATLDLAEAL-------K 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 229 DSEKCyQRSLSEYKLPDGNTIQMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMK-CDTDIQENLFAEIVLSGGTTLF 307
Cdd:cd10208 190 KSPIC-EVLSDGADLASGTEITVGKERFRACEPLFKPSSLRVDLLIAAIAGALVLNAsDEPDKRPALWENIIIVGGGSRI 268
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 308 PGLQDRLLKELE--VLAFEGTP-------IKITASPD---------RCYSAWIGGSVMTSLT----TFKqMWVTAEDFKE 365
Cdd:cd10208 269 RGLKEALLSELQqfHLISETSAspqqpriIRLAKIPDyfpewkksgYEEAAFLGASIVAKLVfndpSSK-HYISKVDYNE 347

                ....*.
gi 62078651 366 YGAFVV 371
Cdd:cd10208 348 KGPAAI 353
ASKHA_NBD_AtArp8-like cd13396
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and ...
12-365 2.89e-27

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and similar proteins; Arabidopsis thaliana ARP8, also called F-box protein ARP8, is an F-Box protein localized to the nucleolus. It is ubiquitously expressed in all organs and cell types and has a cell cycle-dependent subcellular pattern of distribution: it is localized to the nucleolus in interphase cells and dispersed in the cytoplasm in mitotic cells.


Pssm-ID: 466847  Cd Length: 332  Bit Score: 109.94  E-value: 2.89e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  12 VIFDNGSGLCKVGISGEIVPRHVINSVVghpKF-NIPSARSNRKRYFVGEEAQCMydglylhypierglvtrwddmeklw 90
Cdd:cd13396   1 IIIDGGSGYCKFGWSNYASPSGRLATFL---EFgNIESPMYARLCHFVFTIMTRM------------------------- 52
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  91 kdlfewelGVKPNEQPVFMTEPSLNPRET----------REKTTEIMFEKfNVPALYLCNHAVGALCASACITGLVLDSG 160
Cdd:cd13396  53 --------QVKPSRQPVVVSLPLCHSDDTesaaasrrqlRGTIFNVLFDM-NVPAVCAVDQAVLALYAANRTSGIVVNIG 123
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 161 DGVTCTVPIYEGYSLpRAITKLYVA--GRDITEHLTRLLLAKGYTFPCILnkaVVDDIKEKLCTVSWGSKdSEKCYQRSL 238
Cdd:cd13396 124 FRVTTIVPVYRGRVM-HDIGVEVVGqgALRLTGFLKELMQQNGIRFPSLY---TVRTIKEKLCYVAEDYE-AELAKDTQA 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 239 SEYKLPDGNTIqMSDHLCQVPEVLFTPEHLGIHDLGISKMVCNSIMKCDTDI---QENLFAEIVLSGGTTLFPGLQDRLL 315
Cdd:cd13396 199 SCEVAGEGWFT-LSNERFKTGEILFQPGLGGMRAMGLHQAVALCMDHCALVHsqgDDGWFKTIVLSGGSACLPGLSERLE 277
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*
gi 62078651 316 KELEVL----AFEGtpIKITASPDRCYSAWIGGSVMTSLTTFKQMW-VTAEDFKE 365
Cdd:cd13396 278 RELRKLlpksLSEG--IRIIPPPLGPDSAWQGAKLISNLSNFPDGWcITKKQFRN 330
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
1-367 1.08e-24

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 104.63  E-value: 1.08e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   1 MLNTARLDNPAVIFDNgsglcKVGISGEIVPRHVINsvvgHPKFNIPSARSNRKrYFVGEEAQCM-----YDglyLHYPI 75
Cdd:cd10206  77 KSNGRRRIPNQVSAKQ-----NKPSKPENVPEDLDA----SSGENWTDTSDYPD-FLVGEEALRLppseeYN---LHWPI 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  76 ERG------------LVTrwDDMEKLWKDLFEWELGVKPNEQP----VFMTEPSLNPRETREkTTEIMFEKFNVPALYLC 139
Cdd:cd10206 144 RRGrlnvhsdggsltAVL--DDLEDIWSHALEEKLEIPRKDLKnyraVLVIPDLFDRRHVKE-LVDLLLRRLGFSSVFVH 220
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 140 NHAV----GALCASACitglVLDSGDGVT--CTVPiyEGYSLPRAITKLYVAGRDITEHLTRLLLAKGytFP---CILNK 210
Cdd:cd10206 221 QESVcatfGAGLSSAC----VVDIGAQKTsvACVE--DGLSIPNSRIRLPYGGDDITRCFLWLLRRSG--FPyreCNLNS 292
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 211 ----AVVDDIKEKLCTVSwgskdsekcyqrslseyklPDGNTIQMSD---HLCQVPEVLFtpeHLGIhdLGISKMVCNSI 283
Cdd:cd10206 293 pldfLLLERLKETYCTLD-------------------QDDIGVQLHEfyvREPGQPTLKY---QFKL--LPLDEAIVQSI 348
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 284 MKCDTDI-QENLFAEIVLSGGTTLFPG----LQDRLLKELEVLAFEGTPIKITASP---DRCYSAWIGGSVMTSLTTFKQ 355
Cdd:cd10206 349 LSCASDElKRKMYSSILLVGGGAKIPGlaeaLEDRLLIKIPSLFEAVETVEVLPPPkdmDPSLLAWKGGAVLACLDSAQE 428
                       410
                ....*....|..
gi 62078651 356 MWVTAEDFKEYG 367
Cdd:cd10206 429 LWITRKEWQRLG 440
syringactin NF040575
syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in ...
304-375 1.40e-15

syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in the plant pathogen Pseudomonas syringae and related species. This model was created, in part, to clarify that the family is real and distinct, rather than an artifact of eukaryotic contamination of bacterial genomic sequence data. As of the creation of this HMM, the family is uncharacterized.


Pssm-ID: 468549 [Multi-domain]  Cd Length: 132  Bit Score: 72.70  E-value: 1.40e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62078651  304 TTLFPGLQDRLLKELEVLAFEGTPIKITASPDRCYSAWIGGSVMTSLTTFKQMWVTAEDFKEYGAFVVQRKC 375
Cdd:NF040575  61 RVNESGFYEKLKKSITEKAPKGALIGMTLDPKPESAAWRGAAMYAASEGFVEMAITKQEYDESGPSIVHRKC 132
ASKHA_NBD_ScArp7-like cd10212
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and ...
7-364 8.76e-14

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and similar proteins; Saccharomyces cerevisiae Arp7, also called actin-like protein 7, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp7 forms a stable heterodimer with Arp9 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466818 [Multi-domain]  Cd Length: 424  Bit Score: 72.06  E-value: 8.76e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651   7 LDNPAVIFDNGSGLCKVGISGEIVPRHVINSVV-------GHPKF-----NIPSARSNRKRyfvGEEAQCMYDglylhyp 74
Cdd:cd10212   1 LNRKCVVIHNGSHRTVAGFSNVELPQCIIPSSYikrtdegGEAEFifgtyNMIDAAAEKRN---GDEVYTLVD------- 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  75 iERGLVTRWDDMEKLWKDLFEWELGVKPNEQPVFMTEPSLNPRETR---EKTTEIMFEKFNVPALYLCNHAVGALCASAC 151
Cdd:cd10212  71 -SQGLPYNWDALEMQWRYLYDTQLKVSPEELPLVITMPATNGKPDMailERYYELAFDKLNVPVFQIVIEPLAIALSMGK 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 152 ITGLVLDSGDGVTCTVPIYEGYSLPRAITKLYVAGR----DITEHLTRLLLAKG----------------YTFPCILN-- 209
Cdd:cd10212 150 SSAFVIDIGASGCNVTPIIDGIVVKNAVVRSKFGGDfldfQVHERLAPLIKEENdmenmadeqkrstdvwYEASTWIQqf 229
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 210 KAVVDDIKEK-LCTVSWGSKDSEKCYQRSLSEYKL-------------PDGNTIQMSDHL--------------C-QVPE 260
Cdd:cd10212 230 KSTMLQVSEKdLFELERYYKEQADIYAKQQEQLKQmdqqlqytaltgsPNNPLVQKKNFLfkplnktltldlkeCyQFAE 309
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 261 VLFTPEHLGIH---DLGISKMVCNSIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELEVL--AFEGTPIKITASPD 335
Cdd:cd10212 310 YLFKPQLISDKfspEDGLGPLMAKSVKKAPEQVYSLLLTNVIITGSTSLIEGMEQRIIKELSIRfpQYKLTTFANQVMMD 389
                       410       420       430
                ....*....|....*....|....*....|
gi 62078651 336 RCYSAWIGGSVMTSLTTFK-QMWVTAEDFK 364
Cdd:cd10212 390 RKIQGWLGALTMANLPSWSlGKWYSKEDYE 419
ASKHA_NBD_MamK cd24009
nucleotide-binding domain (NBD) of the actin-like protein MamK family; MamK, also called ...
32-319 1.60e-09

nucleotide-binding domain (NBD) of the actin-like protein MamK family; MamK, also called magnetosome cytoskeleton protein MamK, is a protein with ATPase activity which forms dynamic cytoplasmic filaments (probably with paralog MamK-like) that may organize magnetosomes into long chains running parallel to the long axis of the cell. Turnover of MamK filaments is probably promoted by MamK-like (e.g.. MamJ and/or LimJ), which provides a monomer pool. MamK forms twisted filaments in the presence of ATP or GTP. It serves to close gaps between magnetosomes in the chain. Interaction with MCP10 is involved in controlling the response to magnetic fields, possibly by controlling flagellar rotation. The MamK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466859 [Multi-domain]  Cd Length: 328  Bit Score: 58.76  E-value: 1.60e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651  32 RHVINSVVGHPKFNIPSARSNrKRYFVGEEAQCMYDGLYLHYPIERGLVTRWD--DMEKLwKDLFEW--ELGVKPNEQPV 107
Cdd:cd24009  22 RFSFRSVVGYPKDIIARKLLG-KEVLFGDEALENRLALDLRRPLEDGVIKEGDdrDLEAA-RELLQHliELALPGPDDEI 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 108 F--MTEPSLNPRETREKTTEIMFEKFN----VPALYLCNHAVGALCASacitgLVLDSGDGVT--CtvpIYEGySLPRA- 178
Cdd:cd24009 100 YavIGVPARASAENKQALLEIARELVDgvmvVSEPFAVAYGLDRLDNS-----LIVDIGAGTTdlC---RMKG-TIPTEe 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078651 179 --ITkLYVAGRDITEHLTRLLLAKgytFP-CILNKAVVDDIKEKLCTVswgSKDSEKCyqrsLSEYKLPDGN-TIQMSDH 254
Cdd:cd24009 171 dqIT-LPKAGDYIDEELVDLIKER---YPeVQLTLNMARRWKEKYGFV---GDASEPV----KVELPVDGKPvTYDITEE 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62078651 255 LCQVPEVLFTPehlgIHDlGISKMvcnsIMKCDTDIQENLFAEIVLSGGTTLFPGLQDRLLKELE 319
Cdd:cd24009 240 LRIACESLVPD----IVE-GIKKL----IASFDPEFQEELRNNIVLAGGGSRIRGLDTYIEKALK 295
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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