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Conserved domains on  [gi|62078549|ref|NP_001013931|]
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WD repeat-containing protein 70 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-499 5.17e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 5.17e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 178 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDAsfkaFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 255
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL----LRTLKG---HTgpVRDVAASADGTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 256 VIDRDGFEVMECIKGdqyivdmantkgHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKQKsvfkprTMQGKKV 334
Cdd:cd00200  77 LWDLETGECVRTLTG------------HTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTD 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 335 IPTTCTYSRDGNLVAAACQNGSIQIWD-------RNLTVHpkfhykqahapgTDT-SCVAFSYDGNVLASRGGDDTLKLW 406
Cdd:cd00200 137 WVNSVAFSPDGTFVASSSQDGTIKLWDlrtgkcvATLTGH------------TGEvNSVAFSPDGEKLLSSSSDGTIKLW 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 407 DVRQFN--KPLFSASDlptlfPMTDCCFSPDDKLIVTGTsvqrgcGSGKLVFFERRTFQRVYEIHITDASVVRCLWHPKL 484
Cdd:cd00200 205 DLSTGKclGTLRGHEN-----GVNSVAFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG 273

                       330
                ....*....|....*
gi 62078549 485 NQIMVGTGNGLAKVY 499
Cdd:cd00200 274 KRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-499 5.17e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 5.17e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 178 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDAsfkaFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 255
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL----LRTLKG---HTgpVRDVAASADGTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 256 VIDRDGFEVMECIKGdqyivdmantkgHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKQKsvfkprTMQGKKV 334
Cdd:cd00200  77 LWDLETGECVRTLTG------------HTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTD 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 335 IPTTCTYSRDGNLVAAACQNGSIQIWD-------RNLTVHpkfhykqahapgTDT-SCVAFSYDGNVLASRGGDDTLKLW 406
Cdd:cd00200 137 WVNSVAFSPDGTFVASSSQDGTIKLWDlrtgkcvATLTGH------------TGEvNSVAFSPDGEKLLSSSSDGTIKLW 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 407 DVRQFN--KPLFSASDlptlfPMTDCCFSPDDKLIVTGTsvqrgcGSGKLVFFERRTFQRVYEIHITDASVVRCLWHPKL 484
Cdd:cd00200 205 DLSTGKclGTLRGHEN-----GVNSVAFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG 273

                       330
                ....*....|....*
gi 62078549 485 NQIMVGTGNGLAKVY 499
Cdd:cd00200 274 KRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
178-499 2.69e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.40  E-value: 2.69e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 178 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAgmdaSFKAFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 255
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA----TGKLLRTLTG---HSgaVTSVAFSPDGKLLASGSDDGTVR 187

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 256 VIDRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKqksvfkPRTMQGKKV 334
Cdd:COG2319 188 LWDLATGKLL------------RTLTGHTGAVRSVAFSPD--GKLLaSGSADGTVRLWDLATGKL------LRTLTGHSG 247

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 335 IPTTCTYSRDGNLVAAACQNGSIQIWDRNltvHPKFHYKQAHAPGTDTScVAFSYDGNVLASRGGDDTLKLWDVRQfNKP 414
Cdd:COG2319 248 SVRSVAFSPDGRLLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNS-VAFSPDGKLLASGSDDGTVRLWDLAT-GKL 322

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 415 LFSASDLPTlfPMTDCCFSPDDKLIVTGTSvqrgcgSGKLVFFERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNG 494
Cdd:COG2319 323 LRTLTGHTG--AVRSVAFSPDGKTLASGSD------DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADG 394


                ....*
gi 62078549 495 LAKVY 499
Cdd:COG2319 395 TVRLW 399
PTZ00420 PTZ00420
coronin; Provisional
 281-419 2.31e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 57.27  E-value: 2.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549  281 KGHTAMLHTGSWHPKikGEFMTCSN--DATVRLWEVENPKKQKSVFKPRTMQGKKvipttctYSRDGNLVAAACQNGSIQ 358
Cdd:PTZ00420 122 KGHKKKISIIDWNPM--NYYIMCSSgfDSFVNIWDIENEKRAFQINMPKKLSSLK-------WNIKGNLLSGTCVGKHMH 192

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62078549  359 IWD-RNLTVHPKFHykqAHAPGTDTSCV---AFSYDGNVLASRGGDDT----LKLWDVRQFNKPLFSAS 419
Cdd:PTZ00420 193 IIDpRKQEIASSFH---IHDGGKNTKNIwidGLGGDDNYILSTGFSKNnmreMKLWDLKNTTSALVTMS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 178-211 6.25e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 6.25e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 62078549    178 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWD 211
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
383-407 3.45e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 3.45e-03
                          10        20
                  ....*....|....*....|....*
gi 62078549   383 SCVAFSYDGNVLASRGGDDTLKLWD 407
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-499 5.17e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 5.17e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 178 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDAsfkaFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 255
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL----LRTLKG---HTgpVRDVAASADGTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 256 VIDRDGFEVMECIKGdqyivdmantkgHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKQKsvfkprTMQGKKV 334
Cdd:cd00200  77 LWDLETGECVRTLTG------------HTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTD 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 335 IPTTCTYSRDGNLVAAACQNGSIQIWD-------RNLTVHpkfhykqahapgTDT-SCVAFSYDGNVLASRGGDDTLKLW 406
Cdd:cd00200 137 WVNSVAFSPDGTFVASSSQDGTIKLWDlrtgkcvATLTGH------------TGEvNSVAFSPDGEKLLSSSSDGTIKLW 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 407 DVRQFN--KPLFSASDlptlfPMTDCCFSPDDKLIVTGTsvqrgcGSGKLVFFERRTFQRVYEIHITDASVVRCLWHPKL 484
Cdd:cd00200 205 DLSTGKclGTLRGHEN-----GVNSVAFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG 273

                       330
                ....*....|....*
gi 62078549 485 NQIMVGTGNGLAKVY 499
Cdd:cd00200 274 KRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
178-499 2.69e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.40  E-value: 2.69e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 178 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAgmdaSFKAFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 255
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA----TGKLLRTLTG---HSgaVTSVAFSPDGKLLASGSDDGTVR 187

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 256 VIDRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKqksvfkPRTMQGKKV 334
Cdd:COG2319 188 LWDLATGKLL------------RTLTGHTGAVRSVAFSPD--GKLLaSGSADGTVRLWDLATGKL------LRTLTGHSG 247

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 335 IPTTCTYSRDGNLVAAACQNGSIQIWDRNltvHPKFHYKQAHAPGTDTScVAFSYDGNVLASRGGDDTLKLWDVRQfNKP 414
Cdd:COG2319 248 SVRSVAFSPDGRLLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNS-VAFSPDGKLLASGSDDGTVRLWDLAT-GKL 322

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 415 LFSASDLPTlfPMTDCCFSPDDKLIVTGTSvqrgcgSGKLVFFERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNG 494
Cdd:COG2319 323 LRTLTGHTG--AVRSVAFSPDGKTLASGSD------DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADG 394


                ....*
gi 62078549 495 LAKVY 499
Cdd:COG2319 395 TVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
178-409 5.72e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 5.72e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 178 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMdasfKAFRSLQPCEcHQIKSLQYSNTGDMILVVSGSSQAKVI 257
Cdd:COG2319 199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG----KLLRTLTGHS-GSVRSVAFSPDGRLLASGSADGTVRLW 273

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 258 DRDGFEVMECIKGdqyivdmantkgHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKqksvfkPRTMQGKKVIP 336
Cdd:COG2319 274 DLATGELLRTLTG------------HSGGVNSVAFSPD--GKLLaSGSDDGTVRLWDLATGKL------LRTLTGHTGAV 333

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62078549 337 TTCTYSRDGNLVAAACQNGSIQIWDRN---LTVHPKFHYKQAHApgtdtscVAFSYDGNVLASRGGDDTLKLWDVR 409
Cdd:COG2319 334 RSVAFSPDGKTLASGSDDGTVRLWDLAtgeLLRTLTGHTGAVTS-------VAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-407 9.33e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.81  E-value: 9.33e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 178 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAgmdasfkAFRSLQPCECHQ--IKSLQYSNTGDMILVVSGSSQAK 255
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-------TGKCLTTLRGHTdwVNSVAFSPDGTFVASSSQDGTIK 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 256 VIDrdgFEVMECIKgdqyivdmaNTKGHTAMLHTGSWHPKiKGEFMTCSNDATVRLWEVENPKKQKsvfkprTMQGKKVI 335
Cdd:cd00200 161 LWD---LRTGKCVA---------TLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLG------TLRGHENG 221

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62078549 336 PTTCTYSRDGNLVAAACQNGSIQIWD-RNLTVHPKFhykQAHAPGTdtSCVAFSYDGNVLASRGGDDTLKLWD 407
Cdd:cd00200 222 VNSVAFSPDGYLLASGSEDGTIRVWDlRTGECVQTL---SGHTNSV--TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
170-499 5.80e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 5.80e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 170 RIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPcechqIKSLQYSNTGDMILVVS 249
Cdd:COG2319  23 AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA-----VLSVAFSPDGRLLASAS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 250 GSSQAKVIDRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKqksvfkPRT 328
Cdd:COG2319  98 ADGTVRLWDLATGLLL------------RTLTGHTGAVRSVAFSPD--GKTLaSGSADGTVRLWDLATGKL------LRT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 329 MQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWD-------RNLTVHPKFHYkqahapgtdtsCVAFSYDGNVLASRGGDD 401
Cdd:COG2319 158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDlatgkllRTLTGHTGAVR-----------SVAFSPDGKLLASGSADG 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 402 TLKLWDVRQfNKPLFSASDLPtlFPMTDCCFSPDDKLIVTGTsvqrgcGSGKLVFFERRTFQRVYEIHITDASVVRCLWH 481
Cdd:COG2319 227 TVRLWDLAT-GKLLRTLTGHS--GSVRSVAFSPDGRLLASGS------ADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                       330
                ....*....|....*...
gi 62078549 482 PKLNQIMVGTGNGLAKVY 499
Cdd:COG2319 298 PDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 327-499 2.60e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 2.60e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 327 RTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWDRNlTVHPKFHYKQAHAPGTDTSCVAfsyDGNVLASRGGDDTLKLW 406
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-TGELLRTLKGHTGPVRDVAASA---DGTYLASGSSDKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 407 DVRQfNKPLFsasdlpTLF----PMTDCCFSPDDKLIVTGTSvqrgcgSGKLVFFERRTFQRVYEIHITDASVVRCLWHP 482
Cdd:cd00200  79 DLET-GECVR------TLTghtsYVSSVAFSPDGRILSSSSR------DKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP 145

                       170
                ....*....|....*..
gi 62078549 483 KLNQIMVGTGNGLAKVY 499
Cdd:cd00200 146 DGTFVASSSQDGTIKLW 162
WD40 COG2319
WD40 repeat [General function prediction only];
178-316 2.48e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 2.48e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 178 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAgmdaSFKAFRSLQPcECHQIKSLQYSNTGDMILVVSGSSQAKVI 257
Cdd:COG2319 283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549 258 DRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVEN 316
Cdd:COG2319 358 DLATGELL------------RTLTGHTGAVTSVAFSPD--GRTLaSGSADGTVRLWDLAT 403
PTZ00420 PTZ00420
coronin; Provisional
 281-419 2.31e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 57.27  E-value: 2.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549  281 KGHTAMLHTGSWHPKikGEFMTCSN--DATVRLWEVENPKKQKSVFKPRTMQGKKvipttctYSRDGNLVAAACQNGSIQ 358
Cdd:PTZ00420 122 KGHKKKISIIDWNPM--NYYIMCSSgfDSFVNIWDIENEKRAFQINMPKKLSSLK-------WNIKGNLLSGTCVGKHMH 192

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62078549  359 IWD-RNLTVHPKFHykqAHAPGTDTSCV---AFSYDGNVLASRGGDDT----LKLWDVRQFNKPLFSAS 419
Cdd:PTZ00420 193 IIDpRKQEIASSFH---IHDGGKNTKNIwidGLGGDDNYILSTGFSKNnmreMKLWDLKNTTSALVTMS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 178-211 6.25e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 6.25e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 62078549    178 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWD 211
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 383-407 2.14e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 2.14e-03
                           10        20
                   ....*....|....*....|....*
gi 62078549    383 SCVAFSYDGNVLASRGGDDTLKLWD 407
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
383-407 3.45e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 3.45e-03
                          10        20
                  ....*....|....*....|....*
gi 62078549   383 SCVAFSYDGNVLASRGGDDTLKLWD 407
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
178-211 3.62e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.62e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 62078549   178 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWD 211
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 281-460 8.03e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.11  E-value: 8.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549  281 KGHTAMLHTGSWHPKIKGEFMTCSNDATVRLWEVENpKKQKSVFKPRTMQGkkvipTTCTYSRDGNLVAAACQNGSIQIW 360
Cdd:PTZ00421 122 QGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-GKAVEVIKCHSDQI-----TSLEWNLDGSLLCTTSKDKKLNII 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078549  361 D-RNLTVhpkFHYKQAHAPGTDTSCVAFSYDGNVLA---SRGGDDTLKLWDVRQFNKPlFSASDL----PTLFPMtdccF 432
Cdd:PTZ00421 196 DpRDGTI---VSSVEAHASAKSQRCLWAKRKDLIITlgcSKSQQRQIMLWDTRKMASP-YSTVDLdqssALFIPF----F 267

                        170       180
                 ....*....|....*....|....*...
gi 62078549  433 SPDDKLIVTGTSvqrgcGSGKLVFFERR 460
Cdd:PTZ00421 268 DEDTNLLYIGSK-----GEGNIRCFELM 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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