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Conserved domains on  [gi|161353485|ref|NP_001013808|]
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zinc finger and SCAN domain-containing protein 26 isoform b [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
136-297 1.52e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353485 136 QEISKDKGHPCQECGKVFQRSSHLIRHQ--KIHLGE--KPYQCKE--CGKVFSQNAGLLEHLRIHTGEKPYLCI--HCGK 207
Cdd:COG5048  282 SEKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSS 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353485 208 NFRRSSHLNRHQKIHSQDEPRECKE-------CGKTFSRALLLTHHQRVHGRSKRHHCN--ECGKAFSLTSDLIRHHRIH 278
Cdd:COG5048  362 KFSPLLNNEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441

                        170
                 ....*....|....*....
gi 161353485 279 TGEKPFKCNVCQKAFRLNS 297
Cdd:COG5048  442 TNHAPLLCSILKSFRRDLD 460
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 280-335 1.60e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 1.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161353485 280 GEKPFKCNV--CQKAF---------RLNSHLDQ----------HVRIHNEEKPYKCSECNEAFRQKSGLFQHQRHHH 335
Cdd:COG5189  346 DGKPYKCPVegCNKKYknqnglkyhMLHGHQNQklhenpspekMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
136-297 1.52e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353485 136 QEISKDKGHPCQECGKVFQRSSHLIRHQ--KIHLGE--KPYQCKE--CGKVFSQNAGLLEHLRIHTGEKPYLCI--HCGK 207
Cdd:COG5048  282 SEKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSS 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353485 208 NFRRSSHLNRHQKIHSQDEPRECKE-------CGKTFSRALLLTHHQRVHGRSKRHHCN--ECGKAFSLTSDLIRHHRIH 278
Cdd:COG5048  362 KFSPLLNNEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441

                        170
                 ....*....|....*....
gi 161353485 279 TGEKPFKCNVCQKAFRLNS 297
Cdd:COG5048  442 TNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
158-183 4.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 4.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 161353485  158 HLIRHQKIHLGEKPYQCKECGKVFSQ 183
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 280-335 1.60e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 1.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161353485 280 GEKPFKCNV--CQKAF---------RLNSHLDQ----------HVRIHNEEKPYKCSECNEAFRQKSGLFQHQRHHH 335
Cdd:COG5189  346 DGKPYKCPVegCNKKYknqnglkyhMLHGHQNQklhenpspekMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-323 6.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.00e-03
                          10        20
                  ....*....|....*....|....*.
gi 161353485  298 HLDQHVRIHNEEKPYKCSECNEAFRQ 323
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
136-297 1.52e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353485 136 QEISKDKGHPCQECGKVFQRSSHLIRHQ--KIHLGE--KPYQCKE--CGKVFSQNAGLLEHLRIHTGEKPYLCI--HCGK 207
Cdd:COG5048  282 SEKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSS 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353485 208 NFRRSSHLNRHQKIHSQDEPRECKE-------CGKTFSRALLLTHHQRVHGRSKRHHCN--ECGKAFSLTSDLIRHHRIH 278
Cdd:COG5048  362 KFSPLLNNEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441

                        170
                 ....*....|....*....
gi 161353485 279 TGEKPFKCNVCQKAFRLNS 297
Cdd:COG5048  442 TNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
127-337 1.73e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 1.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353485 127 SQSSVAADHQEISKDKGHPCQECGKVFQRSSHLIRHQKIHLG-EKPYQCKECGKVFSQNAGLLEHLR--IHTGE--KPYL 201
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFS 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353485 202 CIH--CGKNFRRSSHLNRHQKIHSQDEPRECK--ECGKTFSRALLLTHHQRVHGRSKRHHCNE------CGKAFSLTSDL 271
Cdd:COG5048  324 CPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNDKKsetlsnSCIRNFKRDSN 403

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 161353485 272 IRHHRIHT---GEKPFKCNVCQKAFRLNSHLDQHVRIHNEEKPYkCSECNEAFRQksglFQHQRHHHKS 337
Cdd:COG5048  404 LSLHIITHlsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRR----DLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
158-183 4.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 4.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 161353485  158 HLIRHQKIHLGEKPYQCKECGKVFSQ 183
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
136-207 7.27e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 7.27e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161353485 136 QEISKDKGHPCQECGKVFQRSSHLIRHQKIHLGEKPYQC--KECGKVFSQNAGLLEHLRIHTGEKPYLCIHCGK 207
Cdd:COG5048   26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
270-293 1.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....
gi 161353485  270 DLIRHHRIHTGEKPFKCNVCQKAF 293
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 280-335 1.60e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 1.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161353485 280 GEKPFKCNV--CQKAF---------RLNSHLDQ----------HVRIHNEEKPYKCSECNEAFRQKSGLFQHQRHHH 335
Cdd:COG5189  346 DGKPYKCPVegCNKKYknqnglkyhMLHGHQNQklhenpspekMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
187-211 4.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.34e-03
                          10        20
                  ....*....|....*....|....*
gi 161353485  187 LLEHLRIHTGEKPYLCIHCGKNFRR 211
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-323 6.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.00e-03
                          10        20
                  ....*....|....*....|....*.
gi 161353485  298 HLDQHVRIHNEEKPYKCSECNEAFRQ 323
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 144-166 8.36e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 8.36e-03
                          10        20
                  ....*....|....*....|...
gi 161353485  144 HPCQECGKVFQRSSHLIRHQKIH 166
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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