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Conserved domains on  [gi|61806679|ref|NP_001013568|]
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N-lysine methyltransferase SMYD2-A [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET super family cl40432
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 7-269 1.85e-123

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


The actual alignment was detected with superfamily member cd19202:

Pssm-ID: 394802 [Multi-domain]  Cd Length: 206  Bit Score: 356.83  E-value: 1.85e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679   7 EGTERFLSPGKGRGLKAIKHFKVGDLVFACPAYAYVLTvnerggrceccftrkeglskcgkckqayycnvecqrgdwpmh 86
Cdd:cd19202   1 GGLERFCSPGKGRGLRALRPFQVGDLLFSCPAYAYVLT------------------------------------------ 38

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679  87 klecsamcaygenwcPSETVRLVARIILKQKHQTERTPSERVLTLRELEAHLDKLDNEKNEMNDTDIAALHHFYSRHLDF 166
Cdd:cd19202  39 ---------------PSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLEF 103

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679 167 PDNAALTELIAQVNCNGFTIEDEELSHLGSALFPDVALMNHSCSPNVIVTYKGTVAEVRAVQEINPEEEIFNSYIDLLYP 246
Cdd:cd19202 104 PDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYP 183

                       250       260
                ....*....|....*....|...
gi 61806679 247 TEDRIERLKDSYFFNCDCKECTS 269
Cdd:cd19202 184 TEDRNDRLRDSYFFTCECQECTT 206
zf-MYND pfam01753
MYND finger;
52-90 2.54e-13

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 63.59  E-value: 2.54e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 61806679    52 CECCFTRKEGLSKCGKCKQAYYCNVECQRGDWPMHKLEC 90
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
TPR_12 pfam13424
Tetratricopeptide repeat;
382-424 7.24e-03

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.44  E-value: 7.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 61806679   382 VASMYLKLGRLYLGLEKRTQGVKALKKALAIMDIAHGKDHPYI 424
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLT 44
 
Name Accession Description Interval E-value
SET_SMYD2 cd19202
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 ...
 7-269 1.85e-123

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins; SMYD2 (also termed HSKM-B, lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML).


Pssm-ID: 380979 [Multi-domain]  Cd Length: 206  Bit Score: 356.83  E-value: 1.85e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679   7 EGTERFLSPGKGRGLKAIKHFKVGDLVFACPAYAYVLTvnerggrceccftrkeglskcgkckqayycnvecqrgdwpmh 86
Cdd:cd19202   1 GGLERFCSPGKGRGLRALRPFQVGDLLFSCPAYAYVLT------------------------------------------ 38

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679  87 klecsamcaygenwcPSETVRLVARIILKQKHQTERTPSERVLTLRELEAHLDKLDNEKNEMNDTDIAALHHFYSRHLDF 166
Cdd:cd19202  39 ---------------PSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLEF 103

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679 167 PDNAALTELIAQVNCNGFTIEDEELSHLGSALFPDVALMNHSCSPNVIVTYKGTVAEVRAVQEINPEEEIFNSYIDLLYP 246
Cdd:cd19202 104 PDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYP 183

                       250       260
                ....*....|....*....|...
gi 61806679 247 TEDRIERLKDSYFFNCDCKECTS 269
Cdd:cd19202 184 TEDRNDRLRDSYFFTCECQECTT 206
zf-MYND pfam01753
MYND finger;
52-90 2.54e-13

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 63.59  E-value: 2.54e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 61806679    52 CECCFTRKEGLSKCGKCKQAYYCNVECQRGDWPMHKLEC 90
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 204-240 9.35e-07

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 47.52  E-value: 9.35e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 61806679   204 LMNHSCSPNVIVTY----KGTVAEVRAVQEINPEEEIFNSY 240
Cdd:pfam00856  74 FINHSCDPNCEVRVvyvnGGPRIVIFALRDIKPGEELTIDY 114
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
204-270 1.67e-04

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 41.49  E-value: 1.67e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61806679 204 LMNHSCSPNVIVTYKGTVAEVRAVQEINPEEEIFnsyIDllYPTEDRIERlkdsyfFNCDCKECTSK 270
Cdd:COG2940  79 FINHSCDPNCEADEEDGRIFIVALRDIAAGEELT---YD--YGLDYDEEE------YPCRCPNCRGT 134
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 195-247 6.59e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 39.63  E-value: 6.59e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 61806679    195 GSALFPDVALMNHSCSPNVIVTY----KGTVAEVRAVQEINPEEEIFNSYIDLLYPT 247
Cdd:smart00317  68 ARRKGNLARFINHSCEPNCELLFvevnGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
TPR_12 pfam13424
Tetratricopeptide repeat;
382-424 7.24e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.44  E-value: 7.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 61806679   382 VASMYLKLGRLYLGLEKRTQGVKALKKALAIMDIAHGKDHPYI 424
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLT 44
 
Name Accession Description Interval E-value
SET_SMYD2 cd19202
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 ...
 7-269 1.85e-123

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins; SMYD2 (also termed HSKM-B, lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML).


Pssm-ID: 380979 [Multi-domain]  Cd Length: 206  Bit Score: 356.83  E-value: 1.85e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679   7 EGTERFLSPGKGRGLKAIKHFKVGDLVFACPAYAYVLTvnerggrceccftrkeglskcgkckqayycnvecqrgdwpmh 86
Cdd:cd19202   1 GGLERFCSPGKGRGLRALRPFQVGDLLFSCPAYAYVLT------------------------------------------ 38

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679  87 klecsamcaygenwcPSETVRLVARIILKQKHQTERTPSERVLTLRELEAHLDKLDNEKNEMNDTDIAALHHFYSRHLDF 166
Cdd:cd19202  39 ---------------PSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLEF 103

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679 167 PDNAALTELIAQVNCNGFTIEDEELSHLGSALFPDVALMNHSCSPNVIVTYKGTVAEVRAVQEINPEEEIFNSYIDLLYP 246
Cdd:cd19202 104 PDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYP 183

                       250       260
                ....*....|....*....|...
gi 61806679 247 TEDRIERLKDSYFFNCDCKECTS 269
Cdd:cd19202 184 TEDRNDRLRDSYFFTCECQECTT 206
SET_SMYD1_2_3-like cd19167
SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, ...
 7-268 5.45e-91

SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, SMYD2, SMYD3 and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1, SMYD2 and SMYD3. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex.


Pssm-ID: 380944 [Multi-domain]  Cd Length: 205  Bit Score: 273.92  E-value: 5.45e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679   7 EGTERFLSPGKGRGLKAIKHFKVGDLVFACPAYAYVLtvnerggrceccftrkeglskcgkckqayycnvecqrgdwpmh 86
Cdd:cd19167   1 GQVERFCSPGKGRGLRALKPFEPGDLIFSERPYAYVL------------------------------------------- 37

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679  87 klecsamcaygenwCPSETVRLVARIILKQKHQTERTpSERVLTLRELEAHLDKLDNEKNEMNDTDIAALHHFYSRHLDF 166
Cdd:cd19167  38 --------------TPPEHVRLTGRILYKQHIRKTRT-SGKLLSVYDLESHVEKLDEEKKDGLRSDVATLHQFMSKDLQL 102

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679 167 PDNAALTELIAQVNCNGFTIEDEELSHLGSALFPDVALMNHSCSPNVIVTYKGTVAEVRAVQEINPEEEIFNSYIDLLYP 246
Cdd:cd19167 103 PDAAYLVELFGKVNCNGFTISDEELQHVGVGIYPQAALLNHSCCPNCIVTFNGPNIEVRAVQEIEPGEEVFHSYIDLLYP 182

                       250       260
                ....*....|....*....|..
gi 61806679 247 TEDRIERLKDSYFFNCDCKECT 268
Cdd:cd19167 183 TEERRDQLRDQYFFLCQCADCQ 204
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 7-269 2.47e-49

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 166.82  E-value: 2.47e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679   7 EGTERFLSPGKGRGLKAIKHFKVGDLVFACPAYAYVLtvnerggrceccFTRKeglskcgkckqayycnvecqrgdwpmh 86
Cdd:cd10526   1 EGVEVFTSEGKGRGLKATKEFWAGDVIFAEPPYAAVV------------FGKA--------------------------- 41

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679  87 klecsamcaygenwcPSETVRLVARIILKQKHQTERTPSERVLTLRELEAHLDKLDNEKNEMNDTDIAALHHFYSRH-LD 165
Cdd:cd10526  42 ---------------PNENIRLAARILWRIEREGGGLKEGELVSIEDLQDHLEDFSEEEKKDLREDVHSFLDYWPYQsQQ 106

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679 166 FPDNAaLTELIAQVNCNGFTIEDEE-LSHLGSALFPDVALMNHSCSPNVIVTYKGTVAEVRAVQEINPEEEIFNSYIDLL 244
Cdd:cd10526 107 FSMEY-ISHIFGVINCNGFTLSDQRgLQAVGVGIFPNLCLVNHDCWPNCTVIFNNGRIELRALGKISEGDELTVSYIDFL 185

                       250       260
                ....*....|....*....|....*
gi 61806679 245 YPTEDRIERLKDSYFFNCDCKECTS 269
Cdd:cd10526 186 NTSEDRKEQLKKQYYFDCTCEHCTK 210
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
 10-268 5.71e-48

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 163.30  E-value: 5.71e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679  10 ERFLSPGKGRGLKAIKHFKVGDLVFACPAYAYVLtvnerggrceccftrkeglskcgkckqayyCNvecqrgDWPMHKLE 89
Cdd:cd19203   4 EKFETAEKGRGLRAVTPLKPGELVLKADPFAYTV------------------------------CN------PPDSVRLE 47

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679  90 CsamcaygenwcpsetvrlvaRIILKQKHQTErTPSERVLTLRELEAHLDKLDNEKNEMNDTDIAALHHF----YSRHLD 165
Cdd:cd19203  48 G--------------------RIIFKLLDKAP-SESEKLYSFYDLQSNINKLSEDRKEGLRQLAMVLQHYlreeIQDASQ 106

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679 166 FPDNAALTELIAQVNCNGFTIEDEELSHLGSALFPDVALMNHSCSPNVIVTYKGTVAEVRAVQEINPEEEIFNSYIDLLY 245
Cdd:cd19203 107 LPPAFDIFELFAKVTCNSFTICDAEMQEVGVGLYPSASLLNHSCDPNCVIVFNGPHLLLRAIREIEVGEELTISYIDMLM 186

                       250       260
                ....*....|....*....|...
gi 61806679 246 PTEDRIERLKDSYFFNCDCKECT 268
Cdd:cd19203 187 PSEERRKQLRDQYCFECDCFRCQ 209
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 176-267 8.24e-26

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 101.30  E-value: 8.24e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679 176 IAQVNCNGFTIEDEElSHLGSALFPDVALMNHSCSPNVIVTYKGT-VAEVRAVQEINPEEEIFNSYIDLLYPTEDRIERL 254
Cdd:cd20071  31 LVSVPSNSFSLTDGL-NEIGVGLFPLASLLNHSCDPNAVVVFDGNgTLRVRALRDIKAGEELTISYIDPLLPRTERRREL 109

                        90
                ....*....|...
gi 61806679 255 KDSYFFNCDCKEC 267
Cdd:cd20071 110 LEKYGFTCSCPRC 122
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 170-267 6.87e-22

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 93.52  E-value: 6.87e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679 170 AALTELIAQVNCNGFTIED--EELSH----------LGSALFPDVALMNHSCSPNVIVTYKGTVAEVRAVQEINPEEEIF 237
Cdd:cd10536 107 GLLLRHLQQLQCNAHAITElqTTSSGsqvdtskqvrIATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPIKKGEEIT 186

                        90       100       110
                ....*....|....*....|....*....|..
gi 61806679 238 NSY--IDLLYPTEDRIERLKDSYFFNCDCKEC 267
Cdd:cd10536 187 ICYgpHFSRMKRSERQRLLKEQYFFDCSCEAC 218
zf-MYND pfam01753
MYND finger;
52-90 2.54e-13

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 63.59  E-value: 2.54e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 61806679    52 CECCFTRKEGLSKCGKCKQAYYCNVECQRGDWPMHKLEC 90
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
SET_SMYD5 cd10521
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 186-269 2.05e-10

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 5 (SMYD5) and similar proteins; SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis.


Pssm-ID: 380919 [Multi-domain]  Cd Length: 282  Bit Score: 61.17  E-value: 2.05e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679 186 IEDEELSHL---GSALFPDVALMNHSCSPNVIVTYKGT--VAEVRAVQEINPEEEIFNSYIDllyptEDRIER------- 253
Cdd:cd10521 190 IEKESGEFLnceGSGLYLLQSCCNHSCVPNAEITFPENnfTLSLKALRDIQEGEEICISYLD-----ECQRERsrhsrqk 264

                        90
                ....*....|....*..
gi 61806679 254 -LKDSYFFNCDCKECTS 269
Cdd:cd10521 265 iLRENYLFICNCPKCEA 281
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 204-240 9.35e-07

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 47.52  E-value: 9.35e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 61806679   204 LMNHSCSPNVIVTY----KGTVAEVRAVQEINPEEEIFNSY 240
Cdd:pfam00856  74 FINHSCDPNCEVRVvyvnGGPRIVIFALRDIKPGEELTIDY 114
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 174-267 3.91e-05

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 43.42  E-value: 3.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679 174 ELIAQVNCNGFTI---EDEELSH--LGSAlfpdvALMNHSCSPNVI-VTYKGTVAEVRAVQEINPEEEIFNSYidllypt 247
Cdd:cd10524  49 EALLRPGGNDFSVmysSRKKCSQlwLGPA-----AFINHDCRPNCKfVPTGKSTACVKVLRDIEPGEEITVYY------- 116

                        90       100
                ....*....|....*....|..
gi 61806679 248 edrierlKDSYFF--NCDCkEC 267
Cdd:cd10524 117 -------GDNYFGenNEEC-EC 130
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
204-270 1.67e-04

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 41.49  E-value: 1.67e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61806679 204 LMNHSCSPNVIVTYKGTVAEVRAVQEINPEEEIFnsyIDllYPTEDRIERlkdsyfFNCDCKECTSK 270
Cdd:COG2940  79 FINHSCDPNCEADEEDGRIFIVALRDIAAGEELT---YD--YGLDYDEEE------YPCRCPNCRGT 134
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 205-240 1.69e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 39.93  E-value: 1.69e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 61806679 205 MNHSCSPNVIVTY----KGTVAEVRAVQEINPEEEIFNSY 240
Cdd:cd08161  32 INHSCEPNCEFEEvyvgGKPRVFIVALRDIKAGEELTVDY 71
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 195-247 6.59e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 39.63  E-value: 6.59e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 61806679    195 GSALFPDVALMNHSCSPNVIVTY----KGTVAEVRAVQEINPEEEIFNSYIDLLYPT 247
Cdd:smart00317  68 ARRKGNLARFINHSCEPNCELLFvevnGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 14-240 2.70e-03

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 39.35  E-value: 2.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679  14 SPGKGRGLKAIKHFKVGDLVFACPAyayvltvnerggrcECCFTRkEGLSKCGKCKQAYYCNVECQRGDWPM-------- 85
Cdd:cd10527   7 SPDGGRGLFATRDIAAGEVLLSVPR--------------SLLLTV-ETARESPLGGAALALLELDPELSWDValalflly 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679  86 --HKLECSAMCAYGEnWCPSE--------TVRLVARiiLKQKHQTERTPSERVLTLRELEAHLDKLDNEKNEMNDTDI-- 153
Cdd:cd10527  72 erARGPDSFWAPYLD-SLPRPfedtplfwSEEELDA--LQGTPLLEAAAAQRRRLREEYEALVEALPEALPAEPGEAFtl 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806679 154 ----AALHHFYSRhldfpdnaalteliaqvncnGFTIEDEELSHlGSALFP--DvaLMNHS-CSPNVIVTYKGTVA--EV 224
Cdd:cd10527 149 eeflWALALVLSR--------------------AFSLPVPDGGG-GLALVPlaD--MLNHSpDAPNVRYEYDEDEGsfVL 205

                       250
                ....*....|....*.
gi 61806679 225 RAVQEINPEEEIFNSY 240
Cdd:cd10527 206 VATRDIAAGEEVFISY 221
TPR_12 pfam13424
Tetratricopeptide repeat;
382-424 7.24e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.44  E-value: 7.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 61806679   382 VASMYLKLGRLYLGLEKRTQGVKALKKALAIMDIAHGKDHPYI 424
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLT 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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