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Conserved domains on  [gi|61556860|ref|NP_001013086|]
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large ribosomal subunit protein mL46 [Rattus norvegicus]

Protein Classification

mL46 family ribosomal protein( domain architecture ID 10570399)

mL46 family ribosomal protein similar to fungal mitochondrial 54S ribosomal protein L17, a component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain

Gene Ontology:  GO:0003735|GO:0032543
PubMed:  24524803

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NUDIX_MRP_L46 cd04661
Mitochondrial ribosomal protein L46; Mitochondrial ribosomal protein L46 (MRP L46) is a ...
 134-273 1.80e-49

Mitochondrial ribosomal protein L46; Mitochondrial ribosomal protein L46 (MRP L46) is a component of the large subunit (39S) of the mammalian mitochondrial ribosome and a member of the NUDIX hydrolase superfamily. MRPs are thought to be involved in the maintenance of the mitochondrial DNA. In general, members of the NUDIX hydrolase superfamily require a divalent cation, such as Mg2+ or Mn2+, for activity and contain the NUDIX motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. MRP L46 appears to contain a modified NUDIX motif.


:

Pssm-ID: 467546  Cd Length: 142  Bit Score: 160.08  E-value: 1.80e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61556860 134 RETEADKKNDRTSLHRKLDRNLILLVREKLGdQDLWMLPQVEWQPGETLRGTAERILATLSENNMEAKFLGNAPCGHYKF 213
Cdd:cd04661  10 RLPEADEKNDRKSLERKLDRTLYLLVKQKKG-KGPWQFPQGDVEEGETLREAAERGLRELGGDNMNTWFVGNAPIGVYKY 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61556860 214 KFPKAIRTEsdlGVKVFFFKALLltgDFVQTGKKGRHVWASKEELGDYLQPKYLAQVRRF 273
Cdd:cd04661  89 KYPKKTKEF---GYKSFFLKGRF---MPGQKKGVSDFAWLTKEELKEYVDPEYWKSVKKM 142
MRP-L46 pfam11788
39S mitochondrial ribosomal protein L46; This is the L46 subunit of the mammalian ...
 43-139 3.98e-17

39S mitochondrial ribosomal protein L46; This is the L46 subunit of the mammalian mitochondrial ribosome, conserved from plants and fungi.


:

Pssm-ID: 432074  Cd Length: 120  Bit Score: 75.28  E-value: 3.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61556860    43 WRLSGALCLQRPPLITKPLTPLQEEM----AGLLQQVEVERSLYSDHELRALDEaQRLAKKKADLYDEEQDQDV-----T 113
Cdd:pfam11788   1 WKISVGLILSRPPVVTPEPSPFEKEYykyqEELLERLMWEFSRYFYFKKGTLAE-LRFKELQKKPIDRLEEIAFpigkpD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 61556860   114 LAQDLEDMWEQEFLQF---------------RPGARETEAD 139
Cdd:pfam11788  80 LRQDRERNDEQEIGLPksgleeseedverriKPAPRVTEAD 120
 
Name Accession Description Interval E-value
NUDIX_MRP_L46 cd04661
Mitochondrial ribosomal protein L46; Mitochondrial ribosomal protein L46 (MRP L46) is a ...
 134-273 1.80e-49

Mitochondrial ribosomal protein L46; Mitochondrial ribosomal protein L46 (MRP L46) is a component of the large subunit (39S) of the mammalian mitochondrial ribosome and a member of the NUDIX hydrolase superfamily. MRPs are thought to be involved in the maintenance of the mitochondrial DNA. In general, members of the NUDIX hydrolase superfamily require a divalent cation, such as Mg2+ or Mn2+, for activity and contain the NUDIX motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. MRP L46 appears to contain a modified NUDIX motif.


Pssm-ID: 467546  Cd Length: 142  Bit Score: 160.08  E-value: 1.80e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61556860 134 RETEADKKNDRTSLHRKLDRNLILLVREKLGdQDLWMLPQVEWQPGETLRGTAERILATLSENNMEAKFLGNAPCGHYKF 213
Cdd:cd04661  10 RLPEADEKNDRKSLERKLDRTLYLLVKQKKG-KGPWQFPQGDVEEGETLREAAERGLRELGGDNMNTWFVGNAPIGVYKY 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61556860 214 KFPKAIRTEsdlGVKVFFFKALLltgDFVQTGKKGRHVWASKEELGDYLQPKYLAQVRRF 273
Cdd:cd04661  89 KYPKKTKEF---GYKSFFLKGRF---MPGQKKGVSDFAWLTKEELKEYVDPEYWKSVKKM 142
MRP-L46 pfam11788
39S mitochondrial ribosomal protein L46; This is the L46 subunit of the mammalian ...
 43-139 3.98e-17

39S mitochondrial ribosomal protein L46; This is the L46 subunit of the mammalian mitochondrial ribosome, conserved from plants and fungi.


Pssm-ID: 432074  Cd Length: 120  Bit Score: 75.28  E-value: 3.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61556860    43 WRLSGALCLQRPPLITKPLTPLQEEM----AGLLQQVEVERSLYSDHELRALDEaQRLAKKKADLYDEEQDQDV-----T 113
Cdd:pfam11788   1 WKISVGLILSRPPVVTPEPSPFEKEYykyqEELLERLMWEFSRYFYFKKGTLAE-LRFKELQKKPIDRLEEIAFpigkpD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 61556860   114 LAQDLEDMWEQEFLQF---------------RPGARETEAD 139
Cdd:pfam11788  80 LRQDRERNDEQEIGLPksgleeseedverriKPAPRVTEAD 120
 
Name Accession Description Interval E-value
NUDIX_MRP_L46 cd04661
Mitochondrial ribosomal protein L46; Mitochondrial ribosomal protein L46 (MRP L46) is a ...
 134-273 1.80e-49

Mitochondrial ribosomal protein L46; Mitochondrial ribosomal protein L46 (MRP L46) is a component of the large subunit (39S) of the mammalian mitochondrial ribosome and a member of the NUDIX hydrolase superfamily. MRPs are thought to be involved in the maintenance of the mitochondrial DNA. In general, members of the NUDIX hydrolase superfamily require a divalent cation, such as Mg2+ or Mn2+, for activity and contain the NUDIX motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. MRP L46 appears to contain a modified NUDIX motif.


Pssm-ID: 467546  Cd Length: 142  Bit Score: 160.08  E-value: 1.80e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61556860 134 RETEADKKNDRTSLHRKLDRNLILLVREKLGdQDLWMLPQVEWQPGETLRGTAERILATLSENNMEAKFLGNAPCGHYKF 213
Cdd:cd04661  10 RLPEADEKNDRKSLERKLDRTLYLLVKQKKG-KGPWQFPQGDVEEGETLREAAERGLRELGGDNMNTWFVGNAPIGVYKY 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61556860 214 KFPKAIRTEsdlGVKVFFFKALLltgDFVQTGKKGRHVWASKEELGDYLQPKYLAQVRRF 273
Cdd:cd04661  89 KYPKKTKEF---GYKSFFLKGRF---MPGQKKGVSDFAWLTKEELKEYVDPEYWKSVKKM 142
MRP-L46 pfam11788
39S mitochondrial ribosomal protein L46; This is the L46 subunit of the mammalian ...
 43-139 3.98e-17

39S mitochondrial ribosomal protein L46; This is the L46 subunit of the mammalian mitochondrial ribosome, conserved from plants and fungi.


Pssm-ID: 432074  Cd Length: 120  Bit Score: 75.28  E-value: 3.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61556860    43 WRLSGALCLQRPPLITKPLTPLQEEM----AGLLQQVEVERSLYSDHELRALDEaQRLAKKKADLYDEEQDQDV-----T 113
Cdd:pfam11788   1 WKISVGLILSRPPVVTPEPSPFEKEYykyqEELLERLMWEFSRYFYFKKGTLAE-LRFKELQKKPIDRLEEIAFpigkpD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 61556860   114 LAQDLEDMWEQEFLQF---------------RPGARETEAD 139
Cdd:pfam11788  80 LRQDRERNDEQEIGLPksgleeseedverriKPAPRVTEAD 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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