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Conserved domains on  [gi|608601794|ref|NP_001012277|]
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PRAME family member 7 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
SCOP:  4003523

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
225-408 1.38e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601794 225 YLGQMRNLRKLVLFNirasACIPPDNKGQFIARFTSQFLkldyfQNLSMHSVSFLEGHLDQL---LRCLQASLEMVVMTD 301
Cdd:cd00116   76 GLTKGCGLQELDLSD----NALGPDGCGVLESLLRSSSL-----QELKLNNNGLGDRGLRLLakgLKDLPPALEKLVLGR 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601794 302 CLLSESDLKHLS-WCPSIRQLKELDLRGVTLTHfspePLTGLLEQAVAT---LQTLDLEDCGIMDSQLSAILPVLSRCSQ 377
Cdd:cd00116  147 NRLEGASCEALAkALRANRDLKELNLANNGIGD----AGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAETLASLKS 222
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 608601794 378 LSTFSFCGNLIS---MAALENLLRHT-VGLSKLSL 408
Cdd:cd00116  223 LEVLNLGDNNLTdagAAALASALLSPnISLLTLSL 257
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
225-408 1.38e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601794 225 YLGQMRNLRKLVLFNirasACIPPDNKGQFIARFTSQFLkldyfQNLSMHSVSFLEGHLDQL---LRCLQASLEMVVMTD 301
Cdd:cd00116   76 GLTKGCGLQELDLSD----NALGPDGCGVLESLLRSSSL-----QELKLNNNGLGDRGLRLLakgLKDLPPALEKLVLGR 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601794 302 CLLSESDLKHLS-WCPSIRQLKELDLRGVTLTHfspePLTGLLEQAVAT---LQTLDLEDCGIMDSQLSAILPVLSRCSQ 377
Cdd:cd00116  147 NRLEGASCEALAkALRANRDLKELNLANNGIGD----AGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAETLASLKS 222
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 608601794 378 LSTFSFCGNLIS---MAALENLLRHT-VGLSKLSL 408
Cdd:cd00116  223 LEVLNLGDNNLTdagAAALASALLSPnISLLTLSL 257
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
219-419 2.52e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 2.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601794 219 LVKFAPYLGQMRNLRKLVLFNirasacippdNKGQFIARFTSQFLKLDYFqNLSMHSVSFLEGHLDQLlrclqASLEMVV 298
Cdd:COG4886  125 LTDLPEELANLTNLKELDLSN----------NQLTDLPEPLGNLTNLKSL-DLSNNQLTDLPEELGNL-----TNLKELD 188
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601794 299 MTDCLLSE--SDLKHLSwcpsirQLKELDLRGVTLTHFsPEPLTGLleqavATLQTLDLEDCGIMDsqlsaiLPVLSRCS 376
Cdd:COG4886  189 LSNNQITDlpEPLGNLT------NLEELDLSGNQLTDL-PEPLANL-----TNLETLDLSNNQLTD------LPELGNLT 250
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 608601794 377 QLSTFSFCGNLIS-------MAALENLLRHTVGLSKLSLELYPAPLESYD 419
Cdd:COG4886  251 NLEELDLSNNQLTdlpplanLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
225-408 1.38e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601794 225 YLGQMRNLRKLVLFNirasACIPPDNKGQFIARFTSQFLkldyfQNLSMHSVSFLEGHLDQL---LRCLQASLEMVVMTD 301
Cdd:cd00116   76 GLTKGCGLQELDLSD----NALGPDGCGVLESLLRSSSL-----QELKLNNNGLGDRGLRLLakgLKDLPPALEKLVLGR 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601794 302 CLLSESDLKHLS-WCPSIRQLKELDLRGVTLTHfspePLTGLLEQAVAT---LQTLDLEDCGIMDSQLSAILPVLSRCSQ 377
Cdd:cd00116  147 NRLEGASCEALAkALRANRDLKELNLANNGIGD----AGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAETLASLKS 222
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 608601794 378 LSTFSFCGNLIS---MAALENLLRHT-VGLSKLSL 408
Cdd:cd00116  223 LEVLNLGDNNLTdagAAALASALLSPnISLLTLSL 257
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
219-419 2.52e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 2.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601794 219 LVKFAPYLGQMRNLRKLVLFNirasacippdNKGQFIARFTSQFLKLDYFqNLSMHSVSFLEGHLDQLlrclqASLEMVV 298
Cdd:COG4886  125 LTDLPEELANLTNLKELDLSN----------NQLTDLPEPLGNLTNLKSL-DLSNNQLTDLPEELGNL-----TNLKELD 188
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601794 299 MTDCLLSE--SDLKHLSwcpsirQLKELDLRGVTLTHFsPEPLTGLleqavATLQTLDLEDCGIMDsqlsaiLPVLSRCS 376
Cdd:COG4886  189 LSNNQITDlpEPLGNLT------NLEELDLSGNQLTDL-PEPLANL-----TNLETLDLSNNQLTD------LPELGNLT 250
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 608601794 377 QLSTFSFCGNLIS-------MAALENLLRHTVGLSKLSLELYPAPLESYD 419
Cdd:COG4886  251 NLEELDLSNNQLTdlpplanLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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