NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|58865496|ref|NP_001011963|]
View 

ankyrin repeat and SOCS box protein 6 isoform 2 [Rattus norvegicus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-137 6.61e-28

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.43  E-value: 6.61e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   2 AELGLTRAAAVLLQSGANLNFEDPvTYYTALHIAVLRNQPDMVELLVRHGADINRRDRIHEsSPLDLASEEpERLPCLQR 81
Cdd:COG0666  95 ARNGDLEIVKLLLEAGADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAAAN-GNLEIVKL 171

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 58865496  82 LLDLGADVNAADKNGKTALLHAlassdgVQIHNTDNIRLLLEGGADVKATTKDGDT 137
Cdd:COG0666 172 LLEAGADVNARDNDGETPLHLA------AENGHLEIVKLLLEAGADVNAKDNDGKT 221
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 295-338 2.31e-24

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239695  Cd Length: 44  Bit Score: 93.66  E-value: 2.31e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 58865496 295 SYPPPLKHLCRVSIRLCLRPWPVDTKVKALPLPDRLKWYLLSAH 338
Cdd:cd03725   1 SYPPPLKHLCRVFIRLCLRPWPVDVKVKALPLPDRLKWYLLPEH 44
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-137 6.61e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.43  E-value: 6.61e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   2 AELGLTRAAAVLLQSGANLNFEDPvTYYTALHIAVLRNQPDMVELLVRHGADINRRDRIHEsSPLDLASEEpERLPCLQR 81
Cdd:COG0666  95 ARNGDLEIVKLLLEAGADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAAAN-GNLEIVKL 171

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 58865496  82 LLDLGADVNAADKNGKTALLHAlassdgVQIHNTDNIRLLLEGGADVKATTKDGDT 137
Cdd:COG0666 172 LLEAGADVNARDNDGETPLHLA------AENGHLEIVKLLLEAGADVNAKDNDGKT 221
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 295-338 2.31e-24

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 93.66  E-value: 2.31e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 58865496 295 SYPPPLKHLCRVSIRLCLRPWPVDTKVKALPLPDRLKWYLLSAH 338
Cdd:cd03725   1 SYPPPLKHLCRVFIRLCLRPWPVDVKVKALPLPDRLKWYLLPEH 44
PHA03095 PHA03095
ankyrin-like protein; Provisional
 13-209 4.05e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 75.83  E-value: 4.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   13 LLQSGANLNFEDPVTYyTALHIAVLRNQP---DMVELLVRHGADINRRDRiHESSPLDLASEEPERLPCLQRLLDLGADV 89
Cdd:PHA03095  33 LLAAGADVNFRGEYGK-TPLHLYLHYSSEkvkDIVRLLLEAGADVNAPER-CGFTPLHLYLYNATTLDVIKLLIKAGADV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   90 NAADKNGKTAlLHALASSDGVqihNTDNIRLLLEGGADVKATTKDGDTVFTCiifLLGETVCgdkeeapminrfCFQVTQ 169
Cdd:PHA03095 111 NAKDKVGRTP-LHVYLSGFNI---NPKVIRLLLRKGADVNALDLYGMTPLAV---LLKSRNA------------NVELLR 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 58865496  170 LLLAHGADPSECPA-HESLTHICLKSFKLHFPLLRFLLESG 209
Cdd:PHA03095 172 LLIDAGADVYAVDDrFRSLLHHHLQSFKPRARIVRELIRAG 212
Ank_2 pfam12796
Ankyrin repeats (3 copies);
2-93 1.79e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.05  E-value: 1.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496     2 AELGLTRAAAVLLQSGANLNFEDPvTYYTALHIAVLRNQPDMVELLVRHgADINRRDriHESSPLDLASEEpERLPCLQR 81
Cdd:pfam12796   5 AKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD--NGRTALHYAARS-GHLEIVKL 79

                          90
                  ....*....|..
gi 58865496    82 LLDLGADVNAAD 93
Cdd:pfam12796  80 LLEKGADINVKD 91
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 297-335 2.12e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 52.17  E-value: 2.12e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 58865496   297 PPPLKHLCRVSIRLCLRPWPvDTKVKALPLPDRLKWYLL 335
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKRR-LGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 298-335 1.22e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 44.32  E-value: 1.22e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 58865496    298 PPLKHLCRVSIRLCLRpwpvdtKVKALPLPDRLKWYLL 335
Cdd:smart00969   1 RSLQHLCRLAIRRSLG------GIDKLPLPPRLKDYLL 32
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 29-55 1.71e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.03  E-value: 1.71e-05
                           10        20
                   ....*....|....*....|....*..
gi 58865496     29 YTALHIAVLRNQPDMVELLVRHGADIN 55
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 27-104 1.95e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 46.34  E-value: 1.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496  27 TYY---TALHIAVLRNQPDMVELLVRHGADINRRD-----RIHESSPLDLASEEPERLPCLQRLLDL----------GAD 88
Cdd:cd22196  90 SYYkgqTALHIAIERRNMHLVELLVQNGADVHARAsgeffKKKKGGPGFYFGELPLSLAACTNQLDIvkfllenphsPAD 169

                        90
                ....*....|....*.
gi 58865496  89 VNAADKNGKTaLLHAL 104
Cdd:cd22196 170 ISARDSMGNT-VLHAL 184
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 30-105 2.28e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 39.68  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496    30 TALHIAVLRNQPDMVELLVRHGADIN------------RRDRI-HESSPLD----LASEEPERLpclqrLLDLGADVNAA 92
Cdd:TIGR00870 130 TALHLAAHRQNYEIVKLLLERGASVParacgdffvksqGVDSFyHGESPLNaaacLGSPSIVAL-----LSEDPADILTA 204

                          90
                  ....*....|...
gi 58865496    93 DKNGKTaLLHALA 105
Cdd:TIGR00870 205 DSLGNT-LLHLLV 216
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-137 6.61e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.43  E-value: 6.61e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   2 AELGLTRAAAVLLQSGANLNFEDPvTYYTALHIAVLRNQPDMVELLVRHGADINRRDRIHEsSPLDLASEEpERLPCLQR 81
Cdd:COG0666  95 ARNGDLEIVKLLLEAGADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAAAN-GNLEIVKL 171

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 58865496  82 LLDLGADVNAADKNGKTALLHAlassdgVQIHNTDNIRLLLEGGADVKATTKDGDT 137
Cdd:COG0666 172 LLEAGADVNARDNDGETPLHLA------AENGHLEIVKLLLEAGADVNAKDNDGKT 221
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-213 1.74e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.88  E-value: 1.74e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   1 MAELGLTRAAAVLLQSGANLNFEDPVTYYTALHIAVLRNQPDMVELLVRHGADINRRDRIHEsSPLDLASEEpERLPCLQ 80
Cdd:COG0666  60 AAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGE-TPLHLAAYN-GNLEIVK 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496  81 RLLDLGADVNAADKNGKTALLHAlassdgVQIHNTDNIRLLLEGGADVKATTKDGDTVFTCIIFllgetvCGDKEeapmi 160
Cdd:COG0666 138 LLLEAGADVNAQDNDGNTPLHLA------AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAE------NGHLE----- 200

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 58865496 161 nrfcfqVTQLLLAHGADPSEcPAHESLTHICLKSFKLHFPLLRFLLESGAAYN 213
Cdd:COG0666 201 ------IVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 295-338 2.31e-24

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 93.66  E-value: 2.31e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 58865496 295 SYPPPLKHLCRVSIRLCLRPWPVDTKVKALPLPDRLKWYLLSAH 338
Cdd:cd03725   1 SYPPPLKHLCRVFIRLCLRPWPVDVKVKALPLPDRLKWYLLPEH 44
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-137 4.39e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 100.03  E-value: 4.39e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   2 AELGLTRAAAVLLQSGANLNFEDPvTYYTALHIAVLRNQPDMVELLVRHGADINRRDRiHESSPLDLASEEpERLPCLQR 81
Cdd:COG0666 128 AYNGNLEIVKLLLEAGADVNAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAEN-GHLEIVKL 204

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 58865496  82 LLDLGADVNAADKNGKTALLHAlassdgVQIHNTDNIRLLLEGGADVKATTKDGDT 137
Cdd:COG0666 205 LLEAGADVNAKDNDGKTALDLA------AENGNLEIVKLLLEAGADLNAKDKDGLT 254
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-213 4.95e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.00  E-value: 4.95e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   1 MAELGLTRAAAVLLQSGANLNFEDPVTYYTALHIAVLRNQPDMVELLVRHGADINRRDRiHESSPLDLASEEpERLPCLQ 80
Cdd:COG0666  27 AAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD-GGNTLLHAAARN-GDLEIVK 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496  81 RLLDLGADVNAADKNGKTALLHAlassdgVQIHNTDNIRLLLEGGADVKATTKDGDTVFTCIIFllgetvCGDKEeapmi 160
Cdd:COG0666 105 LLLEAGADVNARDKDGETPLHLA------AYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA------NGNLE----- 167

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 58865496 161 nrfcfqVTQLLLAHGADPsECPAHESLTHICLKSFKLHFPLLRFLLESGAAYN 213
Cdd:COG0666 168 ------IVKLLLEAGADV-NARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-132 2.93e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.07  E-value: 2.93e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   2 AELGLTRAAAVLLQSGANLNFEDPvTYYTALHIAVLRNQPDMVELLVRHGADINRRDRIHEsSPLDLASEEpERLPCLQR 81
Cdd:COG0666 161 AANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGK-TALDLAAEN-GNLEIVKL 237

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 58865496  82 LLDLGADVNAADKNGKTALLHALASSDGVQIHNTDNIRLLLEGGADVKATT 132
Cdd:COG0666 238 LLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
PHA03095 PHA03095
ankyrin-like protein; Provisional
 13-209 4.05e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 75.83  E-value: 4.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   13 LLQSGANLNFEDPVTYyTALHIAVLRNQP---DMVELLVRHGADINRRDRiHESSPLDLASEEPERLPCLQRLLDLGADV 89
Cdd:PHA03095  33 LLAAGADVNFRGEYGK-TPLHLYLHYSSEkvkDIVRLLLEAGADVNAPER-CGFTPLHLYLYNATTLDVIKLLIKAGADV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   90 NAADKNGKTAlLHALASSDGVqihNTDNIRLLLEGGADVKATTKDGDTVFTCiifLLGETVCgdkeeapminrfCFQVTQ 169
Cdd:PHA03095 111 NAKDKVGRTP-LHVYLSGFNI---NPKVIRLLLRKGADVNALDLYGMTPLAV---LLKSRNA------------NVELLR 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 58865496  170 LLLAHGADPSECPA-HESLTHICLKSFKLHFPLLRFLLESG 209
Cdd:PHA03095 172 LLIDAGADVYAVDDrFRSLLHHHLQSFKPRARIVRELIRAG 212
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 13-144 1.69e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.85  E-value: 1.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   13 LLQSGANLNfedPVTYY--TALHIAVLRNQPD--MVELLVRHGADINRRDRIhesspldlaseeperlpclQRLLDLGAD 88
Cdd:PHA03100 127 LLDNGANVN---IKNSDgeNLLHLYLESNKIDlkILKLLIDKGVDINAKNRV-------------------NYLLSYGVP 184

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 58865496   89 VNAADKNGKTALLHAlassdgVQIHNTDNIRLLLEGGADVKATTKDGDtvfTCIIF 144
Cdd:PHA03100 185 INIKDVYGFTPLHYA------VYNNNPEFVKYLLDLGANPNLVNKYGD---TPLHI 231
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 295-335 4.23e-13

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 62.90  E-value: 4.23e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 58865496 295 SYPPPLKHLCRVSIRLCLRPWPvDTKVKALPLPDRLKWYLL 335
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRRR-LELIKKLPLPPRLKDYLL 40
PHA03095 PHA03095
ankyrin-like protein; Provisional
 58-210 8.10e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.90  E-value: 8.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   58 DRIHESSPLD-LASEEPERLPCLQRLLDLGADVNAADKNGKTALlHALASSDGVQIhnTDNIRLLLEGGADVKATTKDGD 136
Cdd:PHA03095   8 DIIMEAALYDyLLNASNVTVEEVRRLLAAGADVNFRGEYGKTPL-HLYLHYSSEKV--KDIVRLLLEAGADVNAPERCGF 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 58865496  137 TVFTCIIFLlgetvcgdKEEAPMINrfcfqvtqLLLAHGAD-PSECPAHESLTHICLKSFKLHFPLLRFLLESGA 210
Cdd:PHA03095  85 TPLHLYLYN--------ATTLDVIK--------LLIKAGADvNAKDKVGRTPLHVYLSGFNINPKVIRLLLRKGA 143
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 297-336 1.30e-11

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 58.64  E-value: 1.30e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 58865496 297 PPPLKHLCRVSIRLCLRPWPVDtKVKALPLPDRLKWYLLS 336
Cdd:cd03587   2 PRSLQHLCRLAIRRCLGKRRLD-LIDKLPLPPRLKDYLLY 40
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 13-133 3.74e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.92  E-value: 3.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   13 LLQSGANLNFEDpVTYYTALHI-----AVLRNQPDMVELLVRHGADINRRDRIHESSPLDLASEEPERLPCLQRLLDLGA 87
Cdd:PHA03100  54 LLDNGADINSST-KNNSTPLHYlsnikYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLLDNGA 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 58865496   88 DVNAADKNGKTaLLHALASSDGVqihNTDNIRLLLEGGADVKATTK 133
Cdd:PHA03100 133 NVNIKNSDGEN-LLHLYLESNKI---DLKILKLLIDKGVDINAKNR 174
Ank_2 pfam12796
Ankyrin repeats (3 copies);
2-93 1.79e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.05  E-value: 1.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496     2 AELGLTRAAAVLLQSGANLNFEDPvTYYTALHIAVLRNQPDMVELLVRHgADINRRDriHESSPLDLASEEpERLPCLQR 81
Cdd:pfam12796   5 AKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD--NGRTALHYAARS-GHLEIVKL 79

                          90
                  ....*....|..
gi 58865496    82 LLDLGADVNAAD 93
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 12-196 2.45e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 61.43  E-value: 2.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   12 VLLQSGANLNFEDPVTYYTALHIAVLRNQPDMVELLVRHGADINRRDRIhESSPLDLASEEpERLPCLQRLLDLGADVNA 91
Cdd:PHA02878 152 LLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKT-NNSPLHHAVKH-YNKPIVHILLENGASTDA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   92 ADKNGKTALLHALASsdgvqIHNTDNIRLLLEGGADVKATTkdgdtvftciiFLLGETVCGDKEEAPminrfcfQVTQLL 171
Cdd:PHA02878 230 RDKCGNTPLHISVGY-----CKDYDILKLLLEHGVDVNAKS-----------YILGLTALHSSIKSE-------RKLKLL 286

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 58865496  172 LAHGADP------SECPAHES-------------LTHICLKSFK 196
Cdd:PHA02878 287 LEYGADInslnsyKLTPLSSAvkqylcinigrilISNICLLKRI 330
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 28-177 1.08e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 59.29  E-value: 1.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   28 YYTALHIAVLRNQPDMVELLVRHGADINRRDRIHeSSPLDLASEEPERLPCLQRLLDL----GADVNAADKNGKTALLHA 103
Cdd:PHA03100  35 PVLPLYLAKEARNIDVVKILLDNGADINSSTKNN-STPLHYLSNIKYNLTDVKEIVKLlleyGANVNAPDNNGITPLLYA 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58865496  104 LASSDGvqihNTDNIRLLLEGGADVKATTKDGDTvftciifLLGETVCGDKEEAPMInrfcfqvtQLLLAHGAD 177
Cdd:PHA03100 114 ISKKSN----SYSIVEYLLDNGANVNIKNSDGEN-------LLHLYLESNKIDLKIL--------KLLIDKGVD 168
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 297-335 2.12e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 52.17  E-value: 2.12e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 58865496   297 PPPLKHLCRVSIRLCLRPWPvDTKVKALPLPDRLKWYLL 335
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKRR-LGAIDKLPLPPLLKDYLL 39
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 40-213 3.25e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 57.97  E-value: 3.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   40 QPDMVELLVRHGADINRRDRIHESSPLDLASEEPE-RLpcLQRLLDLGADVNAADKNGKTALLHALASSdgvqihNTDNI 118
Cdd:PHA02878 146 EAEITKLLLSYGADINMKDRHKGNTALHYATENKDqRL--TELLLSYGANVNIPDKTNNSPLHHAVKHY------NKPIV 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496  119 RLLLEGGADVKATTKDGDT-----VFTCIifllgetvcgdkeeapminrfCFQVTQLLLAHGADPSECPAHESLT--HIC 191
Cdd:PHA02878 218 HILLENGASTDARDKCGNTplhisVGYCK---------------------DYDILKLLLEHGVDVNAKSYILGLTalHSS 276

                        170       180
                 ....*....|....*....|..
gi 58865496  192 LKSFKlhfpLLRFLLESGAAYN 213
Cdd:PHA02878 277 IKSER----KLKLLLEYGADIN 294
Ank_2 pfam12796
Ankyrin repeats (3 copies);
32-131 3.31e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.20  E-value: 3.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496    32 LHIAVLRNQPDMVELLVRHGADINRRDRIHEsSPLDLASEEpERLPCLQRLLDlGADVNAADkNGKTALLHALASsdgvq 111
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGR-TALHLAAKN-GHLEIVKLLLE-HADVNLKD-NGRTALHYAARS----- 71

                          90       100
                  ....*....|....*....|
gi 58865496   112 iHNTDNIRLLLEGGADVKAT 131
Cdd:pfam12796  72 -GHLEIVKLLLEKGADINVK 90
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 2-131 3.98e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.68  E-value: 3.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496    2 AELGLTRAAAVLLQSGANLNFeDPVTYYTALHIAVLRNQPDMVELLVRHGADINRRD----------------------- 58
Cdd:PHA02876 186 AERGNAKMVNLLLSYGADVNI-IALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDlsllkairnedletslllydagf 264

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58865496   59 -----RIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKNGKTALLhaLASSDGvqiHNTDNIRLLLEGGADVKAT 131
Cdd:PHA02876 265 svnsiDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLY--LMAKNG---YDTENIRTLIMLGADVNAA 337
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 30-136 1.07e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 53.72  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   30 TALHIAVLRNQPDMVELLVRHGADINRRD-------------------RI-----HESSPL---DLASEEPER--LPCLQ 80
Cdd:PLN03192 560 TPLHIAASKGYEDCVLVLLKHACNVHIRDangntalwnaisakhhkifRIlyhfaSISDPHaagDLLCTAAKRndLTAMK 639

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 58865496   81 RLLDLGADVNAADKNGKTALLHALASSdgvqihNTDNIRLLLEGGADVKATTKDGD 136
Cdd:PLN03192 640 ELLKQGLNVDSEDHQGATALQVAMAED------HVDMVRLLIMNGADVDKANTDDD 689
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 6-139 4.35e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.60  E-value: 4.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496    6 LTRAAAVLLQSGANLNFEDpVTYYTALHIaVLRNQPDM--VELLVRHGADINRRDRIHeSSPLDLASEEPERLPCLQRLL 83
Cdd:PHA02876 286 LSRLVPKLLERGADVNAKN-IKGETPLYL-MAKNGYDTenIRTLIMLGADVNAADRLY-ITPLHQASTLDRNKDIVITLL 362

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 58865496   84 DLGADVNAADKNGKTAlLHALASSDGVQIHNTdnirlLLEGGADVKATTKDGDTVF 139
Cdd:PHA02876 363 ELGANVNARDYCDKTP-IHYAAVRNNVVIINT-----LLDYGADIEALSQKIGTAL 412
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 298-335 1.22e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 44.32  E-value: 1.22e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 58865496    298 PPLKHLCRVSIRLCLRpwpvdtKVKALPLPDRLKWYLL 335
Cdd:smart00969   1 RSLQHLCRLAIRRSLG------GIDKLPLPPRLKDYLL 32
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 3-141 1.41e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.60  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496    3 ELGLTRAAAVLLQSGanlNFEDPVTY---YTALHIAVLRNQPDMVELLVRHGA--DINRRDRiheSSPLDLASEEPErLP 77
Cdd:PHA02875  77 EEGDVKAVEELLDLG---KFADDVFYkdgMTPLHLATILKKLDIMKLLIARGAdpDIPNTDK---FSPLHLAVMMGD-IK 149

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58865496   78 CLQRLLDLGADVNAADKNGKTALLHALASSdgvqihNTDNIRLLLEGGADVKATTKDGDTVFTC 141
Cdd:PHA02875 150 GIELLIDHKACLDIEDCCGCTPLIIAMAKG------DIAICKMLLDSGANIDYFGKNGCVAALC 207
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 13-130 1.99e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 49.68  E-value: 1.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   13 LLQSGANLNFEDpvtYY--TALHIAVLRNQPDMVELLVRHGADINR-RDRIHESSPLDLASEEPerLPCLQRLLDLGADV 89
Cdd:PHA02876 361 LLELGANVNARD---YCdkTPIHYAAVRNNVVIINTLLDYGADIEAlSQKIGTALHFALCGTNP--YMSVKTLIDRGANV 435

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 58865496   90 NAADKNGKTALLHALASSDGVQIhntdnIRLLLEGGADVKA 130
Cdd:PHA02876 436 NSKNKDLSTPLHYACKKNCKLDV-----IEMLLDNGADVNA 471
PHA03095 PHA03095
ankyrin-like protein; Provisional
 30-146 2.15e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.25  E-value: 2.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   30 TALHI--AVLRNQPDMVELLVRHGADINRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKNGKTALLHALASS 107
Cdd:PHA03095 189 SLLHHhlQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFN 268

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 58865496  108 dgvqihNTDNIRLLLEGGADVKATTKDGdtvFTCIIFLL 146
Cdd:PHA03095 269 ------NPRACRRLIALGADINAVSSDG---NTPLSLMV 298
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 29-127 3.40e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.45  E-value: 3.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   29 YTALHIAVLRNQPDMVELLVRHGADINRRDrIHESSPLDLASEEPERLPClQRLLDLGADVNAADKNGKTALLhalasSD 108
Cdd:PHA02875 136 FSPLHLAVMMGDIKGIELLIDHKACLDIED-CCGCTPLIIAMAKGDIAIC-KMLLDSGANIDYFGKNGCVAAL-----CY 208

                         90
                 ....*....|....*....
gi 58865496  109 GVQIHNTDNIRLLLEGGAD 127
Cdd:PHA02875 209 AIENNKIDIVRLFIKRGAD 227
PHA02798 PHA02798
ankyrin-like protein; Provisional
 21-137 3.41e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 48.68  E-value: 3.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   21 NFEDPVTYYTALHIAVLRNQP--DMVELLVRHGADINRRDRiHESSPL-DLAS---EEPERLPCLQRLLDLGADVNAADK 94
Cdd:PHA02798  29 NPNEIVNEYSIFQKYLQRDSPstDIVKLFINLGANVNGLDN-EYSTPLcTILSnikDYKHMLDIVKILIENGADINKKNS 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 58865496   95 NGKTALLHALASSdgvQIHNTDNIRLLLEGGADVKATTKDGDT 137
Cdd:PHA02798 108 DGETPLYCLLSNG---YINNLEILLFMIENGADTTLLDKDGFT 147
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 30-129 4.75e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.14  E-value: 4.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   30 TALHIAVLRNQPDM-VELLVRHGADINRRDRiHESSPLDLASEEPERLPCLQRLLDLGADVNAADKNGKTALLHALassd 108
Cdd:PHA02876 410 TALHFALCGTNPYMsVKTLIDRGANVNSKNK-DLSTPLHYACKKNCKLDVIEMLLDNGADVNAINIQNQYPLLIAL---- 484

                         90       100
                 ....*....|....*....|.
gi 58865496  109 gvQIHNTDNIrlLLEGGADVK 129
Cdd:PHA02876 485 --EYHGIVNI--LLHYGAELR 501
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1-137 7.18e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.75  E-value: 7.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496    1 MAELGL-TRAAAVLLQSGANLNFEDPVtYYTALHIA-VLRNQPDMVELLVRHGADINRRDrIHESSPLDLASEEpERLPC 78
Cdd:PHA02876 314 MAKNGYdTENIRTLIMLGADVNAADRL-YITPLHQAsTLDRNKDIVITLLELGANVNARD-YCDKTPIHYAAVR-NNVVI 390

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 58865496   79 LQRLLDLGADVNAADKNGKTALLHALASSDGVQihntdNIRLLLEGGADVKATTKDGDT 137
Cdd:PHA02876 391 INTLLDYGADIEALSQKIGTALHFALCGTNPYM-----SVKTLIDRGANVNSKNKDLST 444
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 29-59 1.11e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.89  E-value: 1.11e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 58865496    29 YTALHIAVLR-NQPDMVELLVRHGADINRRDR 59
Cdd:pfam00023   3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PHA02798 PHA02798
ankyrin-like protein; Provisional
 13-128 1.19e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 46.75  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   13 LLQSGANLNFEDPvTYYTAL-----HIAVLRNQPDMVELLVRHGADINRRDRIHEsSPLD--LASEEPERLPCLQRLLDL 85
Cdd:PHA02798  57 FINLGANVNGLDN-EYSTPLctilsNIKDYKHMLDIVKILIENGADINKKNSDGE-TPLYclLSNGYINNLEILLFMIEN 134

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 58865496   86 GADVNAADKNGKTALLHALASSDGVQIhntDNIRLLLEGGADV 128
Cdd:PHA02798 135 GADTTLLDKDGFTMLQVYLQSNHHIDI---EIIKLLLEKGVDI 174
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 29-55 1.71e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.03  E-value: 1.71e-05
                           10        20
                   ....*....|....*....|....*..
gi 58865496     29 YTALHIAVLRNQPDMVELLVRHGADIN 55
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 27-104 1.95e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 46.34  E-value: 1.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496  27 TYY---TALHIAVLRNQPDMVELLVRHGADINRRD-----RIHESSPLDLASEEPERLPCLQRLLDL----------GAD 88
Cdd:cd22196  90 SYYkgqTALHIAIERRNMHLVELLVQNGADVHARAsgeffKKKKGGPGFYFGELPLSLAACTNQLDIvkfllenphsPAD 169

                        90
                ....*....|....*.
gi 58865496  89 VNAADKNGKTaLLHAL 104
Cdd:cd22196 170 ISARDSMGNT-VLHAL 184
Ank_5 pfam13857
Ankyrin repeats (many copies);
29-69 2.05e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 2.05e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 58865496    29 YTALHIAVLRNQPDMVELLVRHGADINRRDRiHESSPLDLA 69
Cdd:pfam13857  17 YTPLHVAAKYGALEIVRVLLAYGVDLNLKDE-EGLTALDLA 56
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 42-138 3.03e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 44.42  E-value: 3.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   42 DMVELLVRHGADINRRDRIHESSPLD--LASEEPERLPCLQRLLDLGADVNAADKNGKTaLLHALASSDGVQIhntDNIR 119
Cdd:PHA02859  67 EILKFLIENGADVNFKTRDNNLSALHhyLSFNKNVEPEILKILIDSGSSITEEDEDGKN-LLHMYMCNFNVRI---NVIK 142

                         90
                 ....*....|....*....
gi 58865496  120 LLLEGGADVKATTKDGDTV 138
Cdd:PHA02859 143 LLIDSGVSFLNKDFDNNNI 161
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 28-55 4.66e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.93  E-value: 4.66e-05
                          10        20
                  ....*....|....*....|....*...
gi 58865496    28 YYTALHIAVLRNQPDMVELLVRHGADIN 55
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 12-130 5.14e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 45.05  E-value: 5.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   12 VLLQSGANLNFEDpVTYYTALHIAVlrNQPDMVEL---LVRHGADINRRDrIHESSPLDLASEEPERLPCLQRLLDLGAD 88
Cdd:PHA02876 258 LLYDAGFSVNSID-DCKNTPLHHAS--QAPSLSRLvpkLLERGADVNAKN-IKGETPLYLMAKNGYDTENIRTLIMLGAD 333

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 58865496   89 VNAADKNGKTAlLHALASSDgvqiHNTDNIRLLLEGGADVKA 130
Cdd:PHA02876 334 VNAADRLYITP-LHQASTLD----RNKDIVITLLELGANVNA 370
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 297-336 5.61e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 39.89  E-value: 5.61e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 58865496 297 PPPLKHLCRVSIRLCLRpwpVDtKVKALPLPDRLKWYLLS 336
Cdd:cd03717   3 VRSLQHLCRFVIRQCTR---RD-LIDQLPLPRRLKDYLKE 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 8-114 8.77e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.18  E-value: 8.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496    8 RAAAVLLQSGANLNFEDpVTYYTALHIAVlrNQP---DMVELLVRHGADINRRDRIHEsSPLDLASEEPERLPCLQRLLD 84
Cdd:PHA02874 235 RSAIELLINNASINDQD-IDGSTPLHHAI--NPPcdiDIIDILLYHKADISIKDNKGE-NPIDTAFKYINKDPVIKDIIA 310

                         90       100       110
                 ....*....|....*....|....*....|
gi 58865496   85 LGADVNAADKNGKTALLHALASSDGVQIHN 114
Cdd:PHA02874 311 NAVLIKEADKLKDSDFLEHIEIKDNKEFSD 340
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 82-188 9.94e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 9.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   82 LLDLGADVNAADKNGKTaLLHaLASSDG-VQIhntdnIRLLLEGGADVKATTKDGDTVFTciifLLGETVCGDkeeapmi 160
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRT-PLH-IACANGhVQV-----VRVLLEFGADPTLLDKDGKTPLE----LAEENGFRE------- 162

                         90       100       110
                 ....*....|....*....|....*....|.
gi 58865496  161 nrfcfqVTQLLLAHGADPSE---CPAHESLT 188
Cdd:PTZ00322 163 ------VVQLLSRHSQCHFElgaNAKPDSFT 187
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 297-335 1.02e-04

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 39.83  E-value: 1.02e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 58865496 297 PPPLKHLCRVSIRLCLRPWPVDTKV--KALPLPDRLKWYLL 335
Cdd:cd03730   3 PRSLKHLCRLKIRACMGRLRLRCPVfmSFLPLPNRLKAYIL 43
PHA02792 PHA02792
ankyrin-like protein; Provisional
 41-143 1.03e-04

ankyrin-like protein; Provisional


Pssm-ID: 165155 [Multi-domain]  Cd Length: 631  Bit Score: 44.17  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   41 PDMVELLVRHGADI-NRRDRIHESSPL--DLASEEPERLPCLQRLLDLGADVNAADKNGKTALLHALASsdgvqiHNTDN 117
Cdd:PHA02792 352 PKVVEYILKNGNVVvEDDDNIINIMPLfpTLSIHESDVLSILKLCKPYIDDINKIDKHGRSILYYCIES------HSVSL 425

                         90       100
                 ....*....|....*....|....*..
gi 58865496  118 IRLLLEGGADVKATTKDGDTVFT-CII 143
Cdd:PHA02792 426 VEWLIDNGADINITTKYGSTCIGiCVI 452
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 295-336 1.22e-04

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 39.20  E-value: 1.22e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 58865496    295 SYPPPLKHLCRVSIRLCLRPWPVDTkvkaLPLPDRLKWYLLS 336
Cdd:smart00253   5 SNVPSLQHLCRFTIRRCTRTDQIKT----LPLPPKLKDYLSY 42
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 9-105 1.24e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.85  E-value: 1.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   9 AAAVLLQSGANLNFEdPVT--YY---TALHIAVLRNQPDMVELLVRHGADINR--------RDRIHE-----SSPLDLA- 69
Cdd:cd22192  66 AAVVLMEAAPELVNE-PMTsdLYqgeTALHIAVVNQNLNLVRELIARGADVVSpratgtffRPGPKNliyygEHPLSFAa 144

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 58865496  70 ---SEEPERLpclqrLLDLGADVNAADKNGKTaLLHALA 105
Cdd:cd22192 145 cvgNEEIVRL-----LIEHGADIRAQDSLGNT-VLHILV 177
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 298-334 1.28e-04

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 39.06  E-value: 1.28e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 58865496 298 PPLKHLCRVSIRLCLRpwpvdtKVKALPLPDRLKWYL 334
Cdd:cd03736   4 PSLQHLCRITINKCTR------QIQELPLPTRLKDYL 34
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 13-144 1.53e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.41  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   13 LLQSGANLNFEDpVTYYTALHIAVLRNQPDMVELLVRHGADINRRDrIHESSPLDLASEEpERLPCLQRLLDLGADVNAA 92
Cdd:PHA02874 110 ILDCGIDVNIKD-AELKTFLHYAIKKGDLESIKMLFEYGADVNIED-DNGCYPIHIAIKH-NFFDIIKLLLEKGAYANVK 186

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 58865496   93 DKNGKTALLHALASSDgvqihnTDNIRLLLEGGADVKATTKDGDT-VFTCIIF 144
Cdd:PHA02874 187 DNNGESPLHNAAEYGD------YACIKLLIDHGNHIMNKCKNGFTpLHNAIIH 233
Ank_4 pfam13637
Ankyrin repeats (many copies);
62-108 1.56e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 1.56e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 58865496    62 ESSPLDLASEEpERLPCLQRLLDLGADVNAADKNGKTALLHALASSD 108
Cdd:pfam13637   1 ELTALHAAAAS-GHLELLRLLLEKGADINAVDGNGETALHFAASNGN 46
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 12-55 2.20e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.67  E-value: 2.20e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 58865496   12 VLLQSGANLNFEDPVTYYTALHIAVLRNQPDMVELLVRHGADIN 55
Cdd:PHA02875 186 MLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCN 229
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 297-335 2.82e-04

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 38.05  E-value: 2.82e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 58865496 297 PPPLKHLCRVSIRLCLRPWPvDTKVKALPLPDRLKWYLL 335
Cdd:cd03718   3 PLPLMDLCRRRVRVALGRDR-LEEIEQLPLPPSLKNYLL 40
PHA03095 PHA03095
ankyrin-like protein; Provisional
 47-109 3.02e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.32  E-value: 3.02e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 58865496   47 LVRHGADINRRDRiHESSPLDLASEEPERLPCLqRLLDLGADVNAADKNGKTALLHALASSDG 109
Cdd:PHA03095 243 LLIAGISINARNR-YGQTPLHYAAVFNNPRACR-RLIALGADINAVSSDGNTPLSLMVRNNNG 303
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 44-100 3.22e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 3.22e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 58865496   44 VELLVRHGADINRRDrIHESSPLDLASEEpERLPCLQRLLDLGADVNAADKNGKTAL 100
Cdd:PTZ00322  98 ARILLTGGADPNCRD-YDGRTPLHIACAN-GHVQVVRVLLEFGADPTLLDKDGKTPL 152
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 40-210 3.74e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 42.04  E-value: 3.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   40 QPDMVELLVRHGADINRRDRIheSSPL-------DLASEEPERLpcLQRLLDLGADVNAADKNGKTALLHALASSDgvqI 112
Cdd:PHA02989  49 KIKIVKLLIDNGADVNYKGYI--ETPLcavlrnrEITSNKIKKI--VKLLLKFGADINLKTFNGVSPIVCFIYNSN---I 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496  113 HNTDNIRLLLEGGADVKaTTKDGDTVFTCIIFLlgetvcgdkeEAPMINRfcfQVTQLLLAHGADPSECPAHESLT--HI 190
Cdd:PHA02989 122 NNCDMLRFLLSKGINVN-DVKNSRGYNLLHMYL----------ESFSVKK---DVIKILLSFGVNLFEKTSLYGLTpmNI 187

                        170       180
                 ....*....|....*....|..
gi 58865496  191 CLKSF--KLHFPLLRFLLESGA 210
Cdd:PHA02989 188 YLRNDidVISIKVIKYLIKKGV 209
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 12-95 5.65e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.57  E-value: 5.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   12 VLLQSGANLNFEDPVTY---------------YTALHIAVLRNQPDMVELLVRHGADINRRDRIhESSPLDLASeEPERL 76
Cdd:PHA03100 161 LLIDKGVDINAKNRVNYllsygvpinikdvygFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKY-GDTPLHIAI-LNNNK 238

                         90
                 ....*....|....*....
gi 58865496   77 PCLQRLLDLGADVNAADKN 95
Cdd:PHA03100 239 EIFKLLLNNGPSIKTIIET 257
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 297-335 5.89e-04

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 37.50  E-value: 5.89e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 58865496 297 PPPLKHLCRVSIRLCLRPWPVD--TKVKALPLPDRLKWYLL 335
Cdd:cd03731   3 PRPLKHLCRLKIRKLMGLQKLQqpSSMKKLPLPPALKRYIL 43
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 13-100 1.37e-03

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 40.67  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   13 LLQSGANLNFEDPVTYyTALHIAVLRN--QPDMVELLVRHGADINRRDRIHES------------SPLDLASEEPERLPC 78
Cdd:PHA02716 303 FLQPGVKLHYKDSAGR-TCLHQYILRHniSTDIIKLLHEYGNDLNEPDNIGNTvlhtylsmlsvvNILDPETDNDIRLDV 381

                         90       100
                 ....*....|....*....|..
gi 58865496   79 LQRLLDLGADVNAADKNGKTAL 100
Cdd:PHA02716 382 IQCLISLGADITAVNCLGYTPL 403
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 30-120 1.56e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 40.51  E-value: 1.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496  30 TALHIAVLRNQPDMVELLVRHGADINRRDR--------IHE-----SSPLDLA--SEEPErlpCLQRLLDLGAD-VNAAD 93
Cdd:cd22194 143 TALNIAIERRQGDIVKLLIAKGADVNAHAKgvffnpkyKHEgfyfgETPLALAacTNQPE---IVQLLMEKESTdITSQD 219

                        90       100
                ....*....|....*....|....*...
gi 58865496  94 KNGKTaLLHALAS-SDGVQIHNTDNIRL 120
Cdd:cd22194 220 SRGNT-VLHALVTvAEDSKTQNDFVKRM 246
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 28-104 1.60e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 40.16  E-value: 1.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496  28 YY---TALHIAVLRNQPDMVELLVRHGADINRRDR-------------IHESSPLDLA--SEEPERLPCLQRLLDLGADV 89
Cdd:cd22193  73 YYegqTALHIAIERRQGDIVALLVENGADVHAHAKgrffqpkyqgegfYFGELPLSLAacTNQPDIVQYLLENEHQPADI 152

                        90
                ....*....|....*
gi 58865496  90 NAADKNGKTaLLHAL 104
Cdd:cd22193 153 EAQDSRGNT-VLHAL 166
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 12-90 1.92e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 39.58  E-value: 1.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496   12 VLLQSGANLNFEDP---VTYYTALHIAVLRNQPDMVELLVRHGADINRRDRIHESSPLDLaSEEPERLPCLQRLLDLGAD 88
Cdd:PHA02884  51 AILKLGADPEAPFPlseNSKTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYI-SVLHGCLKCLEILLSYGAD 129


                 ..
gi 58865496   89 VN 90
Cdd:PHA02884 130 IN 131
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 30-105 2.28e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 39.68  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496    30 TALHIAVLRNQPDMVELLVRHGADIN------------RRDRI-HESSPLD----LASEEPERLpclqrLLDLGADVNAA 92
Cdd:TIGR00870 130 TALHLAAHRQNYEIVKLLLERGASVParacgdffvksqGVDSFyHGESPLNaaacLGSPSIVAL-----LSEDPADILTA 204

                          90
                  ....*....|...
gi 58865496    93 DKNGKTaLLHALA 105
Cdd:TIGR00870 205 DSLGNT-LLHLLV 216
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 298-334 2.68e-03

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 35.09  E-value: 2.68e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 58865496 298 PPLKHLCRVSIRLCLRPWpvdtKVKALPLPDRLKWYL 334
Cdd:cd03733   4 SSLQHLCRMALRRVMTTQ----QVLALPIPKKMKEFL 36
Ank_5 pfam13857
Ankyrin repeats (many copies);
46-103 3.49e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 3.49e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 58865496    46 LLVRHGADINRRDRiHESSPLDLASEEPeRLPCLQRLLDLGADVNAADKNGKTALLHA 103
Cdd:pfam13857   1 LLEHGPIDLNRLDG-EGYTPLHVAAKYG-ALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV4 cd22195
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 4; TRPV4 is expressed ...
 19-119 5.48e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 4; TRPV4 is expressed broadly in neuronal and non-neuronal cells. It is activated by various stimuli, including hypo-osmolarity, warm temperature, and chemical ligands. TRPV4 acts in physiological functions such as osmoregulation and thermoregulation. It also has a role in mechanosensation in the vascular endothelium and urinary tract, and in cell barrier formation in vascular and epidermal tissues. Knockout mice studies suggested the functional importance of TRPV4 in the central nervous system, nociception, and bone formation. TRPV4 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411979 [Multi-domain]  Cd Length: 733  Bit Score: 38.68  E-value: 5.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496  19 NLNFEDpvTYY---TALHIAVLRNQPDMVELLVRHGADIN--RRDRIHESS-----------PLDLA--SEEPERLPCLQ 80
Cdd:cd22195 127 NSPFRD--VYYrgqTALHIAIERRCKHYVELLVEKGADVHaqARGRFFQPKdeggyfyfgelPLSLAacTNQPDIVHYLT 204

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 58865496  81 RLLDLGADVNAADKNGKTaLLHALassdgvqIHNTDNIR 119
Cdd:cd22195 205 ENAHKKADLRRQDSRGNT-VLHAL-------VAIADNTR 235
Ank_4 pfam13637
Ankyrin repeats (many copies);
28-83 5.73e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.56  E-value: 5.73e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 58865496    28 YYTALHIAVLRNQPDMVELLVRHGADINRRDRIHEsSPLDLASEEpERLPCLQRLL 83
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGE-TALHFAASN-GNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1-101 6.07e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 38.34  E-value: 6.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865496    1 MAELGLTRAAAVLLQSGANLNFEDpvtYY--TALHIAVLRNQPDMVELLVRHGADINRRDRiHESSPLDLASEEPER--- 75
Cdd:PTZ00322  89 LAASGDAVGARILLTGGADPNCRD---YDgrTPLHIACANGHVQVVRVLLEFGADPTLLDK-DGKTPLELAEENGFRevv 164

                         90       100
                 ....*....|....*....|....*....
gi 58865496   76 ---LPCLQRLLDLGADVNAADKNGKTALL 101
Cdd:PTZ00322 165 qllSRHSQCHFELGANAKPDSFTGKPPSL 193
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 295-335 8.86e-03

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 33.66  E-value: 8.86e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 58865496 295 SYPPPLKHLCRVSIRLCLRPWPVDTKVKALPLPDRLKWYLL 335
Cdd:cd03727   1 SAPGTLKALARYAVRRSLGVQYLPEAVKQLPLPRSVKEYLL 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH