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Conserved domains on  [gi|58219535|ref|NP_001010966|]
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GPI mannosyltransferase 2 [Rattus norvegicus]

Protein Classification

glycosyltransferase family protein; YfhO family protein( domain architecture ID 10514647)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein| YfhO family protein is an integral membrane protein similar to Bacillus subtilis YfhO that is essential to lipoteichoic acid (LTA) glycosylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 9-492 4.91e-166

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


:

Pssm-ID: 282094  Cd Length: 439  Bit Score: 476.33  E-value: 4.91e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535     9 KEVLKFAVSCRILTLVLQALFNI-IIPDHHADAFSPPRLAPSGSVDQLVEALLGGLSRWDAEHFLFIAEHGYLYEHNFAF 87
Cdd:pfam04188   2 KELTLYAVLFRSLQLLLVFLTPIrQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYAF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535    88 FPGFPLALLMGT-ELLRPLQGLLSERSCLLVSVALLNSLFSVLAAVALHDLGCLVLHCPRQAFCAALLFCLSPANVFLAA 166
Cdd:pfam04188  82 SPLWPFFVRLFIkSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLTS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535   167 GYSEALFAFLTFSAMGQLERGRGWASGLLFALAAGVRSNGLVSVGFLLHSQCRGFCSSLVVLDPLKGLVKLMASLCLSVL 246
Cdd:pfam04188 162 IYSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSNCVLLGIYFIDLIELTKNRKFVKAICFPFLSGS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535   247 TVSLPFALFQYYAYTQFCFPGSAhaipepllrlasdrgyrlagDYEPPWCSRAPPLIYSYIQDVYWNVGLLRYYELRQVP 326
Cdd:pfam04188 242 LMFLPFLYFQYYLYKTFCPQRSA--------------------GNEPPWCKSQLPLLYSYIQSHYWGVGFLKYWTPKQIP 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535   327 NFLLATPVTVLVVWATWTYVTAHPWLCLTLGLQRTKDRESLEKPHPGFLSAKVFVYLVHAAALLAFGGLCMHVQVLTRLL 406
Cdd:pfam04188 302 NFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQYPSYNKKAEKPDLGFLSPQVFVLVVHTRALVVIVCFFMHVQVLTRFL 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535   407 gSSTPITYWFPAYLLQDREpllrcvdTAPQKLLENSPpgqkaprncVMKLLYNWKTCSpvtkcilvyflTYWLLGLIMHC 486
Cdd:pfam04188 382 -SFLPLHYWFLADLLVSDK-------KKMWNPLGDDK---------IVKFYIYWLACS-----------FYILLGTLLFA 433


                  ....*.
gi 58219535   487 NFLPWT 492
Cdd:pfam04188 434 NFLPPT 439
 
Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 9-492 4.91e-166

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


Pssm-ID: 282094  Cd Length: 439  Bit Score: 476.33  E-value: 4.91e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535     9 KEVLKFAVSCRILTLVLQALFNI-IIPDHHADAFSPPRLAPSGSVDQLVEALLGGLSRWDAEHFLFIAEHGYLYEHNFAF 87
Cdd:pfam04188   2 KELTLYAVLFRSLQLLLVFLTPIrQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYAF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535    88 FPGFPLALLMGT-ELLRPLQGLLSERSCLLVSVALLNSLFSVLAAVALHDLGCLVLHCPRQAFCAALLFCLSPANVFLAA 166
Cdd:pfam04188  82 SPLWPFFVRLFIkSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLTS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535   167 GYSEALFAFLTFSAMGQLERGRGWASGLLFALAAGVRSNGLVSVGFLLHSQCRGFCSSLVVLDPLKGLVKLMASLCLSVL 246
Cdd:pfam04188 162 IYSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSNCVLLGIYFIDLIELTKNRKFVKAICFPFLSGS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535   247 TVSLPFALFQYYAYTQFCFPGSAhaipepllrlasdrgyrlagDYEPPWCSRAPPLIYSYIQDVYWNVGLLRYYELRQVP 326
Cdd:pfam04188 242 LMFLPFLYFQYYLYKTFCPQRSA--------------------GNEPPWCKSQLPLLYSYIQSHYWGVGFLKYWTPKQIP 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535   327 NFLLATPVTVLVVWATWTYVTAHPWLCLTLGLQRTKDRESLEKPHPGFLSAKVFVYLVHAAALLAFGGLCMHVQVLTRLL 406
Cdd:pfam04188 302 NFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQYPSYNKKAEKPDLGFLSPQVFVLVVHTRALVVIVCFFMHVQVLTRFL 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535   407 gSSTPITYWFPAYLLQDREpllrcvdTAPQKLLENSPpgqkaprncVMKLLYNWKTCSpvtkcilvyflTYWLLGLIMHC 486
Cdd:pfam04188 382 -SFLPLHYWFLADLLVSDK-------KKMWNPLGDDK---------IVKFYIYWLACS-----------FYILLGTLLFA 433


                  ....*.
gi 58219535   487 NFLPWT 492
Cdd:pfam04188 434 NFLPPT 439
COG5542 COG5542
Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];
66-214 3.90e-08

Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];


Pssm-ID: 444286 [Multi-domain]  Cd Length: 208  Bit Score: 53.80  E-value: 3.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535  66 WDAEHFLFIAEHGYLY----EHNfAFFPGFPLALLMGTELLRPlqgllserscLLVSVALLNSLFSVLAAVALHDLgCLV 141
Cdd:COG5542   4 FLSPWYRAIATSGYFAalgkQFG-DYFPLYPYLLRLVMYLGLP----------FLLAGKLVSILADLVAAYLLYRW-VKK 71

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 58219535 142 LHCPRQAFCAALLFCLSPANVFLAAGY--SEALFAFLTFSAMGQLERGRGWASGLLFALAAGVRSNGLVSVGFLL 214
Cdd:COG5542  72 YYGGNAALLAAAVLAFLPTVLLNSAIWgqTDSLYTLFSLAALYALLRGRYGWAALFFALATAFKPQAVFLLPALL 146
 
Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 9-492 4.91e-166

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


Pssm-ID: 282094  Cd Length: 439  Bit Score: 476.33  E-value: 4.91e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535     9 KEVLKFAVSCRILTLVLQALFNI-IIPDHHADAFSPPRLAPSGSVDQLVEALLGGLSRWDAEHFLFIAEHGYLYEHNFAF 87
Cdd:pfam04188   2 KELTLYAVLFRSLQLLLVFLTPIrQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYAF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535    88 FPGFPLALLMGT-ELLRPLQGLLSERSCLLVSVALLNSLFSVLAAVALHDLGCLVLHCPRQAFCAALLFCLSPANVFLAA 166
Cdd:pfam04188  82 SPLWPFFVRLFIkSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLTS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535   167 GYSEALFAFLTFSAMGQLERGRGWASGLLFALAAGVRSNGLVSVGFLLHSQCRGFCSSLVVLDPLKGLVKLMASLCLSVL 246
Cdd:pfam04188 162 IYSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSNCVLLGIYFIDLIELTKNRKFVKAICFPFLSGS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535   247 TVSLPFALFQYYAYTQFCFPGSAhaipepllrlasdrgyrlagDYEPPWCSRAPPLIYSYIQDVYWNVGLLRYYELRQVP 326
Cdd:pfam04188 242 LMFLPFLYFQYYLYKTFCPQRSA--------------------GNEPPWCKSQLPLLYSYIQSHYWGVGFLKYWTPKQIP 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535   327 NFLLATPVTVLVVWATWTYVTAHPWLCLTLGLQRTKDRESLEKPHPGFLSAKVFVYLVHAAALLAFGGLCMHVQVLTRLL 406
Cdd:pfam04188 302 NFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQYPSYNKKAEKPDLGFLSPQVFVLVVHTRALVVIVCFFMHVQVLTRFL 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535   407 gSSTPITYWFPAYLLQDREpllrcvdTAPQKLLENSPpgqkaprncVMKLLYNWKTCSpvtkcilvyflTYWLLGLIMHC 486
Cdd:pfam04188 382 -SFLPLHYWFLADLLVSDK-------KKMWNPLGDDK---------IVKFYIYWLACS-----------FYILLGTLLFA 433


                  ....*.
gi 58219535   487 NFLPWT 492
Cdd:pfam04188 434 NFLPPT 439
COG5542 COG5542
Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];
66-214 3.90e-08

Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];


Pssm-ID: 444286 [Multi-domain]  Cd Length: 208  Bit Score: 53.80  E-value: 3.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219535  66 WDAEHFLFIAEHGYLY----EHNfAFFPGFPLALLMGTELLRPlqgllserscLLVSVALLNSLFSVLAAVALHDLgCLV 141
Cdd:COG5542   4 FLSPWYRAIATSGYFAalgkQFG-DYFPLYPYLLRLVMYLGLP----------FLLAGKLVSILADLVAAYLLYRW-VKK 71

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 58219535 142 LHCPRQAFCAALLFCLSPANVFLAAGY--SEALFAFLTFSAMGQLERGRGWASGLLFALAAGVRSNGLVSVGFLL 214
Cdd:COG5542  72 YYGGNAALLAAAVLAFLPTVLLNSAIWgqTDSLYTLFSLAALYALLRGRYGWAALFFALATAFKPQAVFLLPALL 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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