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Conserved domains on  [gi|161016767|ref|NP_001010909|]
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mucin-21 isoform 1 precursor [Homo sapiens]

Protein Classification

Epiglycanin_TR and Epiglycanin_C domain-containing protein( domain architecture ID 10529096)

Epiglycanin_TR and Epiglycanin_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Epiglycanin_C super family cl20615
Mucin, catalytic, TM and cytoplasmic tail region; This family represents the non-tandem repeat ...
 462-552 2.77e-32

Mucin, catalytic, TM and cytoplasmic tail region; This family represents the non-tandem repeat domain including cleavage site, the transmembrane helix domain, and the cytoplasmic tail of epiglycanin and related mucins.


The actual alignment was detected with superfamily member pfam14654:

Pssm-ID: 434100  Cd Length: 91  Bit Score: 119.23  E-value: 2.77e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016767  462 ASTAVSEAKPGGSLVPWEIFLITLVSVVAAVGLFAGLFFCVRN-SLSLRntfNTAVYHPHGLNHGLG--PGPGGNHGAPH 538
Cdd:pfam14654   1 AHTPTNVIKPSGYLQPWEIILISLAAVVAAVGLFVGLSFCLRNfSFPLR---NTAIYYPHGHNLGFGwdLDPGGGHGIFH 77

                          90
                  ....*....|....
gi 161016767  539 RPRWSPNWFWRRPV 552
Cdd:pfam14654  78 SLGNSLARGGGREI 91
Epiglycanin_TR super family cl20301
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ...
 32-97 5.56e-04

Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).


The actual alignment was detected with superfamily member pfam05647:

Pssm-ID: 461702 [Multi-domain]  Cd Length: 68  Bit Score: 38.46  E-value: 5.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 161016767   32 NTGSSVISSGASTATNSGSSVTSSGVSTATISGSSVTSNGVSIVTNSEFHTTSSGISTATNSEFST 97
Cdd:pfam05647   2 STESSTTSSGASTTSNTGSSTTSGGTSTTSNTGSSTTSSGTSTATNTGSSETSSGSSTTSSTGTST 67
 
Name Accession Description Interval E-value
Epiglycanin_C pfam14654
Mucin, catalytic, TM and cytoplasmic tail region; This family represents the non-tandem repeat ...
 462-552 2.77e-32

Mucin, catalytic, TM and cytoplasmic tail region; This family represents the non-tandem repeat domain including cleavage site, the transmembrane helix domain, and the cytoplasmic tail of epiglycanin and related mucins.


Pssm-ID: 434100  Cd Length: 91  Bit Score: 119.23  E-value: 2.77e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016767  462 ASTAVSEAKPGGSLVPWEIFLITLVSVVAAVGLFAGLFFCVRN-SLSLRntfNTAVYHPHGLNHGLG--PGPGGNHGAPH 538
Cdd:pfam14654   1 AHTPTNVIKPSGYLQPWEIILISLAAVVAAVGLFVGLSFCLRNfSFPLR---NTAIYYPHGHNLGFGwdLDPGGGHGIFH 77

                          90
                  ....*....|....
gi 161016767  539 RPRWSPNWFWRRPV 552
Cdd:pfam14654  78 SLGNSLARGGGREI 91
Epiglycanin_TR pfam05647
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ...
 32-97 5.56e-04

Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).


Pssm-ID: 461702 [Multi-domain]  Cd Length: 68  Bit Score: 38.46  E-value: 5.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 161016767   32 NTGSSVISSGASTATNSGSSVTSSGVSTATISGSSVTSNGVSIVTNSEFHTTSSGISTATNSEFST 97
Cdd:pfam05647   2 STESSTTSSGASTTSNTGSSTTSGGTSTTSNTGSSTTSSGTSTATNTGSSETSSGSSTTSSTGTST 67
 
Name Accession Description Interval E-value
Epiglycanin_C pfam14654
Mucin, catalytic, TM and cytoplasmic tail region; This family represents the non-tandem repeat ...
 462-552 2.77e-32

Mucin, catalytic, TM and cytoplasmic tail region; This family represents the non-tandem repeat domain including cleavage site, the transmembrane helix domain, and the cytoplasmic tail of epiglycanin and related mucins.


Pssm-ID: 434100  Cd Length: 91  Bit Score: 119.23  E-value: 2.77e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016767  462 ASTAVSEAKPGGSLVPWEIFLITLVSVVAAVGLFAGLFFCVRN-SLSLRntfNTAVYHPHGLNHGLG--PGPGGNHGAPH 538
Cdd:pfam14654   1 AHTPTNVIKPSGYLQPWEIILISLAAVVAAVGLFVGLSFCLRNfSFPLR---NTAIYYPHGHNLGFGwdLDPGGGHGIFH 77

                          90
                  ....*....|....
gi 161016767  539 RPRWSPNWFWRRPV 552
Cdd:pfam14654  78 SLGNSLARGGGREI 91
Epiglycanin_TR pfam05647
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ...
 32-97 5.56e-04

Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).


Pssm-ID: 461702 [Multi-domain]  Cd Length: 68  Bit Score: 38.46  E-value: 5.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 161016767   32 NTGSSVISSGASTATNSGSSVTSSGVSTATISGSSVTSNGVSIVTNSEFHTTSSGISTATNSEFST 97
Cdd:pfam05647   2 STESSTTSSGASTTSNTGSSTTSGGTSTTSNTGSSTTSSGTSTATNTGSSETSSGSSTTSSTGTST 67
Epiglycanin_TR pfam05647
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ...
 19-83 2.20e-03

Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).


Pssm-ID: 461702 [Multi-domain]  Cd Length: 68  Bit Score: 36.92  E-value: 2.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 161016767   19 EAATNSNETSTSANTGSSVISSGASTATNSGSSVTSSGVSTATISGSSVTSNGVSIVTNSEFHTT 83
Cdd:pfam05647   4 ESSTTSSGASTTSNTGSSTTSGGTSTTSNTGSSTTSSGTSTATNTGSSETSSGSSTTSSTGTSTT 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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