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Conserved domains on  [gi|57114306|ref|NP_001008869|]
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WAP four-disulfide core domain protein 15A precursor [Rattus norvegicus]

Protein Classification

WAP domain-containing protein( domain architecture ID 10442762)

WAP domain-containing protein similar to whey acidic protein (WAP) that could be a protease inhibitor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WAP super family cl00156
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 30-75 1.51e-04

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


The actual alignment was detected with superfamily member cd00199:

Pssm-ID: 469631 [Multi-domain]  Cd Length: 60  Bit Score: 35.89  E-value: 1.51e-04
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....*.
gi 57114306 30 TPKQGYCPEFLLNCPFVLLPLCNRDSGCKGTKKCCFYYCQMRCVEP 75
Cdd:cd00199 14 VEKPGRCPMVNPPSLGIPPNRCSSDSDCPGDKKCCENGCGKSCLTP 59
 
Name Accession Description Interval E-value
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 30-75 1.51e-04

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 35.89  E-value: 1.51e-04
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....*.
gi 57114306 30 TPKQGYCPEFLLNCPFVLLPLCNRDSGCKGTKKCCFYYCQMRCVEP 75
Cdd:cd00199 14 VEKPGRCPMVNPPSLGIPPNRCSSDSDCPGDKKCCENGCGKSCLTP 59
WAP smart00217
Four-disulfide core domains;
32-75 1.95e-04

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 35.42  E-value: 1.95e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 57114306    32 KQGYCPEFLLNCPFVLLPL--CNRDSGCKGTKKCCFYYCQMRCVEP 75
Cdd:smart00217  1 KPGSCPWPTIASCPLGNPPnkCSSDSQCPGVKKCCFNGCGKSCLTP 46
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 32-75 6.89e-04

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 33.94  E-value: 6.89e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 57114306   32 KQGYCPEFLLNCPfvLLPLCNRDSGCKGTKKCCFYYCQMRCVEP 75
Cdd:pfam00095  1 KPGCCPRLGARGC--CRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
 
Name Accession Description Interval E-value
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 30-75 1.51e-04

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 35.89  E-value: 1.51e-04
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....*.
gi 57114306 30 TPKQGYCPEFLLNCPFVLLPLCNRDSGCKGTKKCCFYYCQMRCVEP 75
Cdd:cd00199 14 VEKPGRCPMVNPPSLGIPPNRCSSDSDCPGDKKCCENGCGKSCLTP 59
WAP smart00217
Four-disulfide core domains;
32-75 1.95e-04

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 35.42  E-value: 1.95e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 57114306    32 KQGYCPEFLLNCPFVLLPL--CNRDSGCKGTKKCCFYYCQMRCVEP 75
Cdd:smart00217  1 KPGSCPWPTIASCPLGNPPnkCSSDSQCPGVKKCCFNGCGKSCLTP 46
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 32-75 6.89e-04

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 33.94  E-value: 6.89e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 57114306   32 KQGYCPEFLLNCPfvLLPLCNRDSGCKGTKKCCFYYCQMRCVEP 75
Cdd:pfam00095  1 KPGCCPRLGARGC--CRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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