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Conserved domains on  [gi|56693267|ref|NP_001008598|]
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diamine acetyltransferase 2a [Danio rerio]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11441181)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
2-143 1.24e-21

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


:

Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 85.82  E-value: 1.24e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56693267   2 DFTIRAATFEDCKDISRMILE-----LAEFEKVSDHVKITQRDLEQDgfsKNPFFHGIIAEVPEHLksreghtkIGYsLY 76
Cdd:COG1247   1 EMTIRPATPEDAPAIAAIYNEaiaegTATFETEPPSEEEREAWFAAI---LAPGRPVLVAEEDGEV--------VGF-AS 68

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56693267  77 FYMYNTWKG-RAVYMVDLYVMAEFRGKGIGKALMTKVSQLGLAAGCTQLNFTVLDWNKSSLDFYLKQG 143
Cdd:COG1247  69 LGPFRPRPAyRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLG 136
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
2-143 1.24e-21

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 85.82  E-value: 1.24e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56693267   2 DFTIRAATFEDCKDISRMILE-----LAEFEKVSDHVKITQRDLEQDgfsKNPFFHGIIAEVPEHLksreghtkIGYsLY 76
Cdd:COG1247   1 EMTIRPATPEDAPAIAAIYNEaiaegTATFETEPPSEEEREAWFAAI---LAPGRPVLVAEEDGEV--------VGF-AS 68

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56693267  77 FYMYNTWKG-RAVYMVDLYVMAEFRGKGIGKALMTKVSQLGLAAGCTQLNFTVLDWNKSSLDFYLKQG 143
Cdd:COG1247  69 LGPFRPRPAyRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLG 136
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 71-143 2.74e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 57.53  E-value: 2.74e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56693267    71 IGYSLYFYMYNTWKgrAVYMVDLYVMAEFRGKGIGKALMTKVSQLGLAAGCTQLNFTVLDWNKSSLDFYLKQG 143
Cdd:pfam00583  45 VGFASLSIIDDEPP--VGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIALYEKLG 115
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 65-124 5.08e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 42.26  E-value: 5.08e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56693267  65 REGHTKIGYSLYFYmyNTWKGRAVYMVDLYVMAEFRGKGIGKALMTKVSQLGLAAGCTQL 124
Cdd:cd04301   5 EDDGEIVGFASLSP--DGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRL 62
PRK10562 PRK10562
putative acetyltransferase; Provisional
 93-143 3.69e-05

putative acetyltransferase; Provisional


Pssm-ID: 236715 [Multi-domain]  Cd Length: 145  Bit Score: 41.59  E-value: 3.69e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 56693267   93 LYVMAEFRGKGIGKALMTKVSQLglaagCTQLNFTVLDWNKSSLDFYLKQG 143
Cdd:PRK10562  74 LFVAPKAVRRGIGKALMQHVQQR-----YPHLSLEVYQKNQRAVNFYHAQG 119
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
2-143 1.24e-21

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 85.82  E-value: 1.24e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56693267   2 DFTIRAATFEDCKDISRMILE-----LAEFEKVSDHVKITQRDLEQDgfsKNPFFHGIIAEVPEHLksreghtkIGYsLY 76
Cdd:COG1247   1 EMTIRPATPEDAPAIAAIYNEaiaegTATFETEPPSEEEREAWFAAI---LAPGRPVLVAEEDGEV--------VGF-AS 68

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56693267  77 FYMYNTWKG-RAVYMVDLYVMAEFRGKGIGKALMTKVSQLGLAAGCTQLNFTVLDWNKSSLDFYLKQG 143
Cdd:COG1247  69 LGPFRPRPAyRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLG 136
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 72-143 6.83e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 61.21  E-value: 6.83e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56693267  72 GYSLYFYMYNtwkGRAVYMVDLYVMAEFRGKGIGKALMTKVSQLGLAAGCTQLNFTVLDWNKSSLDFYLKQG 143
Cdd:COG0456   1 GFALLGLVDG---GDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLG 69
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
5-155 7.45e-12

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 59.71  E-value: 7.45e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56693267   5 IRAATFEDCKDISRMILELAEFEKVSDHVkitqRDLEQDGfsknPFFHGIIAEVPEHLksreghtkIGYSLYFYMYNTWK 84
Cdd:COG3153   1 IRPATPEDAEAIAALLRAAFGPGREAELV----DRLREDP----AAGLSLVAEDDGEI--------VGHVALSPVDIDGE 64

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56693267  85 GRAVYMVDLYVMAEFRGKGIGKALMTKVSQLGLAAGCTQLnftVLDWNKSSLDFYLKQGcWDVTSELGYHC 155
Cdd:COG3153  65 GPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAV---VLLGDPSLLPFYERFG-FRPAGELGLTL 131
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 3-143 1.96e-11

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 58.53  E-value: 1.96e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56693267   3 FTIRAATFEDckdisrmILELAEFEKVSDHVKITQRDLEQDGFsknpffhgIIAEVPEHLksreghtkIGYSLYFYMynt 82
Cdd:COG0454   1 MSIRKATPED-------INFILLIEALDAELKAMEGSLAGAEF--------IAVDDKGEP--------IGFAGLRRL--- 54

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56693267  83 wKGRAVYMVDLYVMAEFRGKGIGKALMTKVSQLGLAAGCTQLNFTVLDWNKSSLDFYLKQG 143
Cdd:COG0454  55 -DDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRFYERLG 114
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 71-143 2.74e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 57.53  E-value: 2.74e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56693267    71 IGYSLYFYMYNTWKgrAVYMVDLYVMAEFRGKGIGKALMTKVSQLGLAAGCTQLNFTVLDWNKSSLDFYLKQG 143
Cdd:pfam00583  45 VGFASLSIIDDEPP--VGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIALYEKLG 115
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
85-157 1.14e-08

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 49.91  E-value: 1.14e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56693267  85 GRAVYMVDLYVMAEFRGKGIGKALMTKVSQLGLAAGCTQLNFTVLDWNKSSLDFYLKQGcWDVTSELGYHCMR 157
Cdd:COG3393  13 PGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLG-FRPVGEYATVLFR 84
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 79-143 8.31e-07

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 44.75  E-value: 8.31e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56693267    79 MYNTWKGRAVYMVDLYVMAEFRGKGIGKALMTKVSQLGLAAGCTQLNftvLDWNKSSLDFYLKQG 143
Cdd:pfam13508  20 LLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLE---LETTNRAAAFYEKLG 81
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 3-143 1.06e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 45.75  E-value: 1.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56693267   3 FTIRAATFEDCKDISRMILELAEFEKVSDhvkitqrdleqdgfsknpFFhgiIAEvpehlksrEGHTKIGY-SLYFYmyn 81
Cdd:COG1246   1 MTIRPATPDDVPAILELIRPYALEEEIGE------------------FW---VAE--------EDGEIVGCaALHPL--- 48

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56693267  82 twKGRAVYMVDLYVMAEFRGKGIGKALMTKVSQLGLAAGCTQLnftVLDWNKSSLDFYLKQG 143
Cdd:COG1246  49 --DEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRL---FLLTTSAAIHFYEKLG 105
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 65-124 5.08e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 42.26  E-value: 5.08e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56693267  65 REGHTKIGYSLYFYmyNTWKGRAVYMVDLYVMAEFRGKGIGKALMTKVSQLGLAAGCTQL 124
Cdd:cd04301   5 EDDGEIVGFASLSP--DGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRL 62
PRK10562 PRK10562
putative acetyltransferase; Provisional
 93-143 3.69e-05

putative acetyltransferase; Provisional


Pssm-ID: 236715 [Multi-domain]  Cd Length: 145  Bit Score: 41.59  E-value: 3.69e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 56693267   93 LYVMAEFRGKGIGKALMTKVSQLglaagCTQLNFTVLDWNKSSLDFYLKQG 143
Cdd:PRK10562  74 LFVAPKAVRRGIGKALMQHVQQR-----YPHLSLEVYQKNQRAVNFYHAQG 119
PRK03624 PRK03624
putative acetyltransferase; Provisional
 93-143 1.66e-04

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 39.53  E-value: 1.66e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 56693267   93 LYVMAEFRGKGIGKALMTKVSQLGLAAGCTQLNFTVLDWNKSSLDFYLKQG 143
Cdd:PRK03624  74 LAVHPDFRGRGIGRALVARLEKKLIARGCPKINLQVREDNDAVLGFYEALG 124
PTZ00330 PTZ00330
acetyltransferase; Provisional
 85-143 4.72e-04

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 38.67  E-value: 4.72e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56693267   85 GRAV-YMVDLYVMAEFRGKGIGKALMTKVSQLGLAAGCTQLnftVLDWNKSSLDFYLKQG 143
Cdd:PTZ00330  79 GKCVgHIEDVVVDPSYRGQGLGRALISDLCEIARSSGCYKV---ILDCTEDMVAFYKKLG 135
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 93-143 1.88e-03

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 36.48  E-value: 1.88e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 56693267    93 LYVMAEFRGKGIGKALMTKVSQLGLAAGCTQLNFTVlDWNKSSLDFYLKQG 143
Cdd:pfam13673  57 LFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTV-NASPYAVPFYEKLG 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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