NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|56699444|ref|NP_001008533|]
View 

adenosine receptor A1 isoform a [Mus musculus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11606768)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
10-299 2.29e-166

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


:

Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 464.32  E-value: 2.29e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLI 89
Cdd:cd15071   1 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEFYSCLMVACPVLI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 LTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPVIKC 169
Cdd:cd15071  81 LTQSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNNLNAVERAWAANSSMGELVIKC 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 EFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLP 249
Cdd:cd15071 161 QFETVISMEYMVYFNFFVWVLPPLLLMLLIYLEVFYLIRKQLNKKVSSSSSDPQKYYGKELKIAKSLALILFLFALSWLP 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444 250 LHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15071 241 LHILNCITLFCPSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
 
Name Accession Description Interval E-value
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
10-299 2.29e-166

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 464.32  E-value: 2.29e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLI 89
Cdd:cd15071   1 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEFYSCLMVACPVLI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 LTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPVIKC 169
Cdd:cd15071  81 LTQSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNNLNAVERAWAANSSMGELVIKC 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 EFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLP 249
Cdd:cd15071 161 QFETVISMEYMVYFNFFVWVLPPLLLMLLIYLEVFYLIRKQLNKKVSSSSSDPQKYYGKELKIAKSLALILFLFALSWLP 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444 250 LHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15071 241 LHILNCITLFCPSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
26-288 6.42e-40

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 140.90  E-value: 6.42e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444    26 GNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF---HTCLMVACPVLILTQSSILALLAIA 102
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPfgsALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444   103 VDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPM-FGWNNLSEveqawiaNGSVGEPVIKCEFEKVISMEYMV 181
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLlFGWTLTVP-------EGNVTVCFIDFPEDLSKPVSYTL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444   182 YFNFFVWVLPPLLLMVLiYLEVFYLIRKQLNKKVSASSGDPQKyygkelKIAKSLALILFLFALSWLPLHILNCITLFCP 261
Cdd:pfam00001 154 LISVLGFLLPLLVILVC-YTLIIRTLRKSASKQKSSERTQRRR------KALKTLAVVVVVFILCWLPYHIVNLLDSLAL 226
                         250       260       270
                  ....*....|....*....|....*....|
gi 56699444   262 TCQKPSIL---IYIAIFLTHGNSAMNPIVY 288
Cdd:pfam00001 227 DCELSRLLdkaLSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
17-295 8.31e-05

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 43.61  E-value: 8.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444   17 VLIALVSVPGNVLVIWaVKVNQALRDATFCFIVSLAVADVaVGALVIPLAILINIGPQTYFHTCL--MVACPVLILTQSS 94
Cdd:PHA03087  48 STIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDL-LFVMTLPFQIYYYILFQWSFGEFAckIVSGLYYIGFYNS 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444   95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVgLTPMFGWNNLSeveqawiangSVGEPVIKCEFEKV 174
Cdd:PHA03087 126 MNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIE-TTPILFVYTTK----------KDHETLICCMFYNN 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  175 ISMEYMVYFNFFVwVLPPLLLMVLIYLEVFYLIRKQLnKKVSASSgdpqkyygKELKIAKSLALILFLFALSWLP----- 249
Cdd:PHA03087 195 KTMNWKLFINFEI-NIIGMLIPLTILLYCYSKILITL-KGINKSK--------KNKKAIKLVLIIVILFVIFWLPfnvsv 264
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 56699444  250 ----LHILNCITLfCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKF 295
Cdd:PHA03087 265 fvysLHILHFKSG-CKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFF 313
 
Name Accession Description Interval E-value
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
10-299 2.29e-166

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 464.32  E-value: 2.29e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLI 89
Cdd:cd15071   1 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEFYSCLMVACPVLI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 LTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPVIKC 169
Cdd:cd15071  81 LTQSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNNLNAVERAWAANSSMGELVIKC 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 EFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLP 249
Cdd:cd15071 161 QFETVISMEYMVYFNFFVWVLPPLLLMLLIYLEVFYLIRKQLNKKVSSSSSDPQKYYGKELKIAKSLALILFLFALSWLP 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444 250 LHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15071 241 LHILNCITLFCPSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
10-299 1.28e-145

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 411.65  E-value: 1.28e-145
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLI 89
Cdd:cd14968   1 AVYIVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLPTNFHGCLFMACLVLV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 LTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEqawianGSVGEPVIKC 169
Cdd:cd14968  81 LTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNNGAPLE------SGCGEGGIQC 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 EFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSA-SSGDPQKYYGKELKIAKSLALILFLFALSWL 248
Cdd:cd14968 155 LFEEVIPMDYMVYFNFFACVLVPLLIMLVIYLRIFRVIRKQLRQIESLlRSRRSRSTLQKEVKAAKSLAIILFLFALCWL 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444 249 PLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd14968 235 PLHIINCITLFCPECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
10-299 7.52e-106

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 310.56  E-value: 7.52e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLI 89
Cdd:cd15070   1 VTYISIEILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGVTIHFYSCLFMSCLLVV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 LTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEqawiangSVGEPVIKC 169
Cdd:cd15070  81 FTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLE-------SVNTTPLQC 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 EFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSgDPQKYYGKELKIAKSLALILFLFALSWLP 249
Cdd:cd15070 154 QFTSVMRMDYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKLSQNATGFR-ETGAFYGREFKTAKSLALVLFLFAVCWLP 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444 250 LHILNCITLFCPtcQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15070 233 LSIINCVVYFNP--KVPKIALYLGILLSHANSMMNPIVYACKIKKFKETY 280
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
12-299 1.84e-94

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 282.21  E-value: 1.84e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  12 YIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILT 91
Cdd:cd15068   3 YITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  92 QSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPVIKCEF 171
Cdd:cd15068  83 QSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 172 EKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNK-KVSASSGDPQK-YYGKELKIAKSLALILFLFALSWLP 249
Cdd:cd15068 163 EDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQmESQPLPGERARsTLQKEVHAAKSLAIIVGLFALCWLP 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444 250 LHILNCITLFCPTCQKPSILI-YIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15068 243 LHIINCFTFFCPDCSHAPLWLmYLAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
10-299 9.70e-89

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 267.57  E-value: 9.70e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLI 89
Cdd:cd15069   1 ATYVALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFHSCLFLACFVLV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 LTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNN----LSEVEQAWIANGSVGEP 165
Cdd:cd15069  81 LTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKamsaTNNSTNPADHGTNHSCC 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 166 VIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKkvSASSGDPQKYYGKELKIAKSLALILFLFAL 245
Cdd:cd15069 161 LISCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQR--TELMDHSRTTLQREIHAAKSLAIIVGIFAL 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444 246 SWLPLHILNCITLFCPTC--QKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15069 239 CWLPVHILNCITLFQPEFskSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
12-299 8.55e-51

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 168.90  E-value: 8.55e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  12 YIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFH--TCLMVACPVLI 89
Cdd:cd14967   2 LAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGpvLCRFWIALDVL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 LTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVeqawiangsvgePVIKC 169
Cdd:cd14967  82 CCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQP------------SVVDC 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 EFEKVISMEYMVY---FNFFVwvlpPLLLMVLIYLEVFYLIRKqlnkkvsassgdpqkyygkELKIAKSLALILFLFALS 246
Cdd:cd14967 150 ECEFTPNKIYVLVssvISFFI----PLLIMIVLYARIFRVARR-------------------ELKAAKTLAIIVGAFLLC 206
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56699444 247 WLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd14967 207 WLPFFIIYLVSAFCPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
12-291 3.58e-42

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 147.05  E-value: 3.58e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  12 YIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLI 89
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDalCKLLGFLQSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 LTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNnlseveqawiANGSVGEPVIKC 169
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWG----------VYDYGGYCCCCL 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 EFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQ-KYYGKELKIAKSLALILFLFALSWL 248
Cdd:cd00637 151 CWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRrRRRRRERKVTKTLLIVVVVFLLCWL 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56699444 249 PLHILNCITLFCPT-CQKPSILIYIAIFLTHGNSAMNPIVYAFR 291
Cdd:cd00637 231 PYFILLLLDVFGPDpSPLPRILYFLALLLAYLNSAINPIIYAFF 274
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
26-288 6.42e-40

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 140.90  E-value: 6.42e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444    26 GNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF---HTCLMVACPVLILTQSSILALLAIA 102
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPfgsALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444   103 VDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPM-FGWNNLSEveqawiaNGSVGEPVIKCEFEKVISMEYMV 181
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLlFGWTLTVP-------EGNVTVCFIDFPEDLSKPVSYTL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444   182 YFNFFVWVLPPLLLMVLiYLEVFYLIRKQLNKKVSASSGDPQKyygkelKIAKSLALILFLFALSWLPLHILNCITLFCP 261
Cdd:pfam00001 154 LISVLGFLLPLLVILVC-YTLIIRTLRKSASKQKSSERTQRRR------KALKTLAVVVVVFILCWLPYHIVNLLDSLAL 226
                         250       260       270
                  ....*....|....*....|....*....|
gi 56699444   262 TCQKPSIL---IYIAIFLTHGNSAMNPIVY 288
Cdd:pfam00001 227 DCELSRLLdkaLSVTLWLAYVNSCLNPIIY 256
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
17-299 2.57e-35

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 129.37  E-value: 2.57e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTC-LMVACPVLILTqS 93
Cdd:cd15051   8 AVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLgpVFCnIYISLDVMLCT-A 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTP-MFGWNNLSEVEQawiaNGSVGEpviKCEFE 172
Cdd:cd15051  87 SILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPiHLGWNTPDGRVQ----NGDTPN---QCRFE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 kviSMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQK-----YYGKELKIAKSLALILFLFALSW 247
Cdd:cd15051 160 ---LNPPYVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAKRINALTPASTANssksaATAREHKATVTLAAVLGAFIICW 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56699444 248 LPLHILNCITLFCPtCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15051 237 FPYFTYFTYRGLCG-DNINETALSVVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
18-299 1.69e-33

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 125.16  E-value: 1.69e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINI-GPQTYFHT-CLM-VACPVLILTqSS 94
Cdd:cd15065   8 LIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLlGYWLFGETfCNIwISFDVMCST-AS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMF-GWNNLSEVEQAWIANGSVGEPVikCEFEk 173
Cdd:cd15065  87 ILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHlGWHRLSQDEIKGLNHASNPKPS--CALD- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 vISMEYMVYFNFFVWvLPPLLLMVLIYLEVFYLIRKQLNK--------------KVSASSGDPQKYYGKELKIAKSLALI 239
Cdd:cd15065 164 -LNPTYAVVSSLISF-YIPCLVMLLIYSRLYLYARKHVVNiksqklpsesgskfQVPSLSSKHNNQGVSDHKAAVTLGII 241
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 240 LFLFALSWLPLHILNCITLFCPTCqKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15065 242 MGVFLICWLPFFIINIIAAFCKTC-IPPKCFKILTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
18-299 2.76e-30

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 115.53  E-value: 2.76e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMV----ACPVLILTqS 93
Cdd:cd15067   8 LFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYWLFGRDWCdvwhSFDVLAST-A 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWnnlseveqaWIANGSVGEPVIKCEF-E 172
Cdd:cd15067  87 SILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISF-PAIAW---------WRAVDPGPSPPNQCLFtD 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 KVISMEYMVYFNFFVwvlpplllMVLIYLEVFYLIRKqlnkkvSASsgdpqkyygKELKIAKSLALILFLFALSWLPLHI 252
Cdd:cd15067 157 DSGYLIFSSCVSFYI--------PLVVMLFTYYRIYR------AAA---------KEQKAAKTLGIVMGVFILCWLPFFV 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56699444 253 LNCITLFCP--TCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15067 214 TNILIGFCPsnCVSNPDILFPLVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
11-299 1.18e-29

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 114.62  E-value: 1.18e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  11 AYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGpQTYFHTCLMvaCPVLIL 90
Cdd:cd14993   2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVY-RPWVFGEVL--CKAVPY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  91 TQ-----SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEveqawIANGSVGEP 165
Cdd:cd14993  79 LQgvsvsASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIML-PLLVVYELEE-----IISSEPGTI 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 166 VIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLI---YLEVFY--LIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL 240
Cdd:cd14993 153 TIYICTEDWPSPELRKAYNVALFVVLYVLPLLIIsvaYSLIGRrlWRRKPPGDRGSANSTSSRRILRSKKKVARMLIVVV 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56699444 241 FLFALSWLPLHILNCITLFCPTCQKPSILIYIAIF-----LTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd14993 233 VLFALSWLPYYVLSILLDFGPLSSEESDENFLLILpfaqlLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
13-299 2.18e-29

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 112.84  E-value: 2.18e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  13 IGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILI-NIGPQTY-FHTCLMVACPVLIL 90
Cdd:cd15061   3 ISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRqLLGYWPLgSHLCDFWISLDVLL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  91 TQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNlseveqawiangSVGEPVIKCE 170
Cdd:cd15061  83 CTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSW------------HGRRGLGSCY 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 171 FEKviSMEYMVY---FNFFVwvlpPLLLMVLIYLEVFYLIRkqlnkkvsassgdpqkyygKELKIAKSLALILFLFALSW 247
Cdd:cd15061 151 YTY--DKGYRIYssmGSFFL----PLLLMLFVYLRIFRVIA-------------------KERKTAKTLAIVVGCFIVCW 205
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56699444 248 LPLHILNCITLFCPtCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15061 206 LPFFIMYLIEPFCD-CQFSEALSTAFTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
14-299 5.18e-29

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 112.91  E-value: 5.18e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  14 GIEVLIALVSVPGNVLVIWAVKVNQALR-DATFCFIVSLAVADVAVGALVIPLAILINI------GPQTYFHTCLMVACp 86
Cdd:cd15057   5 CILYLLVLLTLLGNALVIAAVLRFRHLRsKVTNYFIVSLAVSDLLVAILVMPWAAVNEVagywpfGSFCDVWVSFDIMC- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  87 vlilTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTP-MFGWNNLSEVEQAWiangSVGEP 165
Cdd:cd15057  84 ----STASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPvQLGWHRADDTSEAL----ALYAD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 166 VIKCEFekVISMEYMV---YFNFFVWVLPPLLLMVLIYLEVFYLIRK--QLNKKVSASSGDPQKYYG---KELKIAKSLA 237
Cdd:cd15057 156 PCQCDS--SLNRTYAIsssLISFYIPVAIMIVTYTRIYRIARRQIRRiaALERAAQESTNPDSSLRSslrRETKALKTLS 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56699444 238 LILFLFALSWLPLHILNCITLFC------PTCQKPSILIyIAIFLTHGNSAMNPIVYAFRiHKFRVTF 299
Cdd:cd15057 234 IIMGVFVCCWLPFFILNCVLPFCdlrtaqFPCVPDTTFI-VFVWLGWANSSLNPIIYAFN-ADFRKAF 299
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
17-299 5.96e-29

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 112.05  E-value: 5.96e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAI--LINIGPQTYFHTC--LMVACPVLILTq 92
Cdd:cd15053   8 LLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVyvEVNGGKWYLGPILcdIYIAMDVMCST- 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAwiangsvgepviKCEFE 172
Cdd:cd15053  87 ASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPE------------ECRFY 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 kviSMEYMVY---FNFFVwvlpplllMVLIYLEVFYLIRKQLnkkvsassgdpqkyyGKELKIAKSLALILFLFALSWLP 249
Cdd:cd15053 155 ---NPDFIIYssiSSFYI--------PCIVMLLLYYRIFRAL---------------RREKKATKTLAIVLGVFLFCWLP 208
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444 250 ---LHILN--CITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15053 209 fftLNILNaiCPKLQNQSCHVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
18-299 7.59e-29

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 111.82  E-value: 7.59e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF-HTCLMVACPVLI-LTQSSI 95
Cdd:cd15063   9 FLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFgHTWCQIWLAVDVwMCTASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQawianGSVGEPVIKCEFEKVI 175
Cdd:cd15063  89 LNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIM-----DYSGSSSLPCTCELTN 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 176 SMEYMVYfnffvwvlpplLLMVLIYLEVFYLIRKQLNKKVSASsgdpqkyygKELKIAKSLALILFLFALSWLPLHILNC 255
Cdd:cd15063 164 GRGYVIY-----------SALGSFYIPMLVMLFFYFRIYRAAR---------METKAAKTVAIIVGCFIFCWLPFFTVYL 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56699444 256 ITLFCPTCQKPsILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15063 224 VRAFCEDCIPP-LLFSVFFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
11-299 1.90e-28

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 110.93  E-value: 1.90e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  11 AYIGIEVLIALVSVPGNVLVIWAVKVNQALRD-ATFCFIVSLAVADVAVGaLVIPLAIL-----INIGPQTYFhtCLMVA 84
Cdd:cd15104   1 AAGVILAVLSPLIITGNLLVIVALLKLIRKKDtKSNCFLLNLAIADFLVG-LAIPGLATdellsDGENTQKVL--CLLRM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  85 CPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMfgwnnLSEVEQAWIANGsvge 164
Cdd:cd15104  78 CFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPL-----ISPQFQQTSYKG---- 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 165 pviKCEFEKVISMEYMVYFNFFVWvLPPLLLMVLIYLEVFYLIRKQLNK----KVSASSGDPQKYYGKELKIAKSLALIL 240
Cdd:cd15104 149 ---KCSFFAAFHPRVLLVLSCMVF-FPALLLFVFCYCDILKIARVHSRAiykvEHALARQIHPRRTLSDFKAARTVAVLI 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56699444 241 FLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15104 225 GCFLLSWLPFQITGLVQALCDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
17-299 2.82e-28

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 110.21  E-value: 2.82e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTCLM-VACPVLILTqS 93
Cdd:cd15060   8 SVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFgiHLCQMwLTCDILCCT-A 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNlseveqaWIANGSVGEPVIKCEfEK 173
Cdd:cd15060  87 SILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWND-------WPENFTETTPCTLTE-EK 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 VismeYMVYF---NFFVwvlpPLLLMVLIYLEVFylirkqlnkkVSASsgdpqkyygKELKIAKSLALILFLFALSWLPL 250
Cdd:cd15060 159 G----YVIYSssgSFFI----PLLIMTIVYVKIF----------IATS---------KERRAARTLGIIMGVFVVCWLPF 211
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56699444 251 HILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15060 212 FLMYVILPFCETCSPSAKVVNFITWLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
19-299 3.23e-28

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 110.46  E-value: 3.23e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  19 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGalvipLAILINIGPQTYFHTCLMVACPVLILTQ------ 92
Cdd:cd14972   8 LGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAG-----IAFVFTFLSVLLVSLTPSPATWLLRKGSlvlsll 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIangSVGEPvikcefe 172
Cdd:cd14972  83 ASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLGWNCVLCDQESCS---PLGPG------- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 kvISMEYMVYFNFFVwvLPPLLLMVLIYLEVFYLIRKQLN---KKVSASSGDPQKyygKELKIAKSLALILFLFALSWLP 249
Cdd:cd14972 153 --LPKSYLVLILVFF--FIALVIIVFLYVRIFWCLWRHANaiaARQEAAVPAQPS---TSRKLAKTVVIVLGVFLVCWLP 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444 250 LHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd14972 226 LLILLVLDVLCPSVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
17-299 6.46e-28

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 109.64  E-value: 6.46e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSS 94
Cdd:cd15314   8 GLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDlfCKIHSSFDITLCTAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIAngSVGEPVIkcEFEKV 174
Cdd:cd15314  88 ILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLELNIKGIYYNHVA--CEGGCLV--FFSKV 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 175 ISMEYMVyFNFFVwvlpPLLLMVLIYLEVFYLIRKQ---LNKKVSASSGDPQKyygKELKIAKSLALILFLFALSWLPLH 251
Cdd:cd15314 164 SSVVGSV-FSFYI----PAVIMLCIYLKIFLVAQRQarsIQSARTKSGASSSK---MERKATKTLAIVMGVFLLCWTPFF 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56699444 252 ILNCITLFCPtCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15314 236 LCNIIDPFIN-YSIPPVLIEVLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
17-290 9.04e-27

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 106.48  E-value: 9.04e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTCLMVACPVLILTQSS 94
Cdd:cd15055   8 SSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFgdTFCKLHSSLDYILTSAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQawiANGSVGEPVIkcefekV 174
Cdd:cd15055  88 IFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQPGLIR---YNSCYGECVV------V 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 175 ISMEYMVyFNFFVWVLPPLLLMVLIYLEVFYLIRKQ------LNKKVSA---SSGDPQKyygKELKIAKSLALILFLFAL 245
Cdd:cd15055 159 VNFIWGV-VDLVLTFILPCTVMIVLYMRIFVVARSQarairsHTAQVSLegsSKKVSKK---SERKAAKTLGIVVGVFLL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56699444 246 SWLPLHilnCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAF 290
Cdd:cd15055 235 CWLPYY---IVSLVDPYISTPSSVFDVLIWLGYFNSCLNPLIYAL 276
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
10-299 1.94e-26

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 105.12  E-value: 1.94e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCL---MVACP 86
Cdd:cd15059   1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWceiWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  87 VLILTqSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWnnlsEVEQAWIAngsvGEPv 166
Cdd:cd15059  81 VLFCT-ASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGW----KDEQPWHG----AEP- 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 167 iKCEFEKviSMEYMVY---FNFFVwvlpPLLLMVLIYLEVFYLIRKqlnkkvsassgdpqkyygKELKIAKSLALILFLF 243
Cdd:cd15059 151 -QCELSD--DPGYVLFssiGSFYI----PLLIMIIVYARIYRAAKR------------------KERRFTLVLGVVMGAF 205
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444 244 ALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15059 206 VLCWLPFFFTYPLVVVCKTCGVPELLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
17-299 2.96e-26

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 105.61  E-value: 2.96e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIG---PQTYFHTCLMVACPVLILTqS 93
Cdd:cd15058   8 ALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTgkwQLGNFWCELWTSVDVLCVT-A 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTP-MFGWNNLSEVEqawiANGSVGEPVIkCEFe 172
Cdd:cd15058  87 SIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPiMNQWWRANDPE----ANDCYQDPTC-CDF- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 kVISMEYMVyFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNK---------------------KVSASSGDPQKYYG-KEL 230
Cdd:cd15058 161 -RTNMAYAI-ASSVVSFYIPLLIMIFVYARVFLIATRQLQLidkrrlrfqsecpapqttspeGKRSSGRRPSRLTVvKEH 238
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 231 KIAKSLALILFLFALSWLPLHILNCITLFCPTCqkPSILIYIAI-FLTHGNSAMNPIVYAfRIHKFRVTF 299
Cdd:cd15058 239 KALKTLGIIMGTFTLCWLPFFIANIINVFNRNL--PPGEVFLLLnWLGYINSGLNPIIYC-RSPEFRTAF 305
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
17-299 3.35e-26

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 104.33  E-value: 3.35e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILI------NIGPQTyfhtC-LMVACPVLI 89
Cdd:cd15064   8 SLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYeltgrwILGQVL----CdIWISLDVTC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 LTqSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGW-NNLSEVEQAWIANGSVGepvik 168
Cdd:cd15064  84 CT-ASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWrTPDSEDPSECLISQDIG----- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 169 cefekvismeYMVYFNFFVWVLPPLllmvlIYLEVFYLIRKqlnkkvSASsgdpqkyygKELKIAKSLALILFLFALSWL 248
Cdd:cd15064 158 ----------YTIFSTFGAFYIPLL-----LMLILYWKIYR------AAA---------RERKAAKTLGIILGAFIVCWL 207
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444 249 PLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15064 208 PFFLVALIVPLCSHCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
19-299 5.55e-26

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 104.05  E-value: 5.55e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  19 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFH--TCLMVACPVLILTQSSIL 96
Cdd:cd15050  10 ISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGrpVCLFWLSMDYVASTASIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  97 ALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLvVGLTPMFGWNNLSEVeqawianGSVGEPVIKC--EFEKV 174
Cdd:cd15050  90 SLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSF-LWVIPILGWHHFARG-------GERVVLEDKCetDFHDV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 175 ISMEYMVYF-NFFVwvlpPLLLMVLIYLEVFYLIRkqlnkkvsassgdpqkyygKELKIAKSLALILFLFALSWLPLHIL 253
Cdd:cd15050 162 TWFKVLTAIlNFYI----PSLLMLWFYAKIFKAVN-------------------RERKAAKQLGFIMAAFILCWIPYFIL 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 56699444 254 NCITLFCPTCQKPSiLIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15050 219 FMVIAFCKNCCNEN-LHMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
19-299 1.36e-25

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 102.95  E-value: 1.36e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  19 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSSIL 96
Cdd:cd15062  10 FILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRifCDVWAAVDVLCCTASIM 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  97 ALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNnlseveqawiangsvgEPVIKCEFEKVIS 176
Cdd:cd15062  90 SLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWK----------------EPAPADEQACGVN 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 177 ME-YMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKqlnkkvsassgdpqkyYGKELKIAKSLALILFLFALSWLPLHILNC 255
Cdd:cd15062 154 EEpGYVLFSSLGSFYLPLAIILVMYCRVYVVAFK----------------FSREKKAAKTLGIVVGAFVLCWFPFFVVLP 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56699444 256 ITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15062 218 LGSLFSTLKPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
18-299 3.30e-25

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 101.96  E-value: 3.30e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLM-VACPVLILTqSS 94
Cdd:cd15329   9 IIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEilCDVwISFDVLLCT-AS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQawiangsvgepviKCEFEKv 174
Cdd:cd15329  88 ILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKVNDPG-------------VCQVSQ- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 175 iSMEYMVYFNFFVWvlpplllmvLIYLEVFYLIRKQLNKKVSassgdpqkyygKELKIAKSLALILFLFALSWLPLHILN 254
Cdd:cd15329 154 -DFGYQIYATFGAF---------YIPLIVMLVLYYKIYRAAK-----------SERKAIKTLGIIMGAFTLCWLPFFILA 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56699444 255 CITLFC---PTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15329 213 LLRPFLkpiKCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
17-299 1.13e-24

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 100.74  E-value: 1.13e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSS 94
Cdd:cd14969   8 SLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDpgCVIYGFAVTFLGLVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTvVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLseveqawiangsVGEPV-----IKC 169
Cdd:cd14969  88 ISTLAALAFERYLVIVRPLKAFR-LSKRRALILIAFIWLYGLFWALPPLFGWSSY------------VPEGGgtscsVDW 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 EFEKVISMEYMVY---FNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYygkELKIAKSLALILFLFALS 246
Cdd:cd14969 155 YSKDPNSLSYIVSlfvFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKKA---EKKVAKMVLVMIVAFLIA 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56699444 247 WLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd14969 232 WTPYAVVSLYVSFGGESTIPPLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
17-299 1.42e-24

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 100.77  E-value: 1.42e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTclmVACPVLILTQ---- 92
Cdd:cd15207   8 SLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGD---VMCKLSPLVQgvsv 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 -SSILALLAIAVDRYLRVKIPLRYKtvVTQRRAAVAIAGCWILSLVVGLTPMFgwnnLSEVEQAWIangSVGEPVIKCEf 171
Cdd:cd15207  85 aASVFTLVAIAVDRYRAVVHPTEPK--LTNRQAFVIIVAIWVLALAIMIPQAL----VLEVKEYQF---FRGQTVHICV- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 172 EKVISMEYMVYFNFFVWVLPPLLLMVLI---YLEVFYLI-RKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSW 247
Cdd:cd15207 155 EFWPSDEYRKAYTTSLFVLCYVAPLLIIavlYVRIGYRLwFKPVPGGGSASREAQAAVSKKKVRVIKMLIVVVVLFALSW 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 56699444 248 LPLHILNCITLFCPTCQKPSILIYIAIF-----LTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15207 235 LPLHTVTMLDDFGNLSPNQREVLYVYIYpiahwLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
21-299 3.42e-24

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 99.20  E-value: 3.42e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  21 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSSILAL 98
Cdd:cd15326  12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRifCDIWAAVDVLCCTASILSL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  99 LAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNnlseveqawiangsvgEPVIKCEFEKVISME 178
Cdd:cd15326  92 CAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWK----------------EPAPPDDKVCEITEE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 179 -YMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKqlnkkvsassgdpqkyYGKELKIAKSLALILFLFALSWLPLHILNCIT 257
Cdd:cd15326 156 pFYALFSSLGSFYIPLIVILVMYCRVYIVALK----------------FSREKKAAKTLGIVVGMFILCWLPFFIALPLG 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56699444 258 LFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15326 220 SLFSHLKPPETLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
21-299 8.84e-24

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 98.04  E-value: 8.84e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  21 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSSILAL 98
Cdd:cd15325  12 LFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRvfCNIWAAVDVLCCTASIMSL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  99 LAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNnlseveqawiangsvgEPVIKCEFEKVISME 178
Cdd:cd15325  92 CIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWK----------------EPAPEDETICQITEE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 179 Y-MVYFNFFVWVLPPLLLMVLIYLEVFYLIRKqlnkkvsassgdpqkyYGKELKIAKSLALILFLFALSWLPLHILNCIT 257
Cdd:cd15325 156 PgYALFSALGSFYLPLAIILVMYCRVYVVALK----------------FSREKKAAKTLGIVVGCFVLCWLPFFLVMPIG 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56699444 258 LFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15325 220 SIFPAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
17-299 1.38e-23

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 97.45  E-value: 1.38e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFH--TCLMV-ACPVLILTqS 93
Cdd:cd15066   7 TLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGyfMCDVWnSLDVYFST-A 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMF-GWNNLSEVEQAWIANGSVgepvikCEFe 172
Cdd:cd15066  86 SILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFlGWYTTEEHLQYRKTHPDQ------CEF- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 kVISMEYMVY---FNFFVWVLPPLLLMVLIYLEVfylirkqlnkkvsassgdpqkyyGKELKIAKSLALILFLFALSWLP 249
Cdd:cd15066 159 -VVNKIYALIsssVSFWIPCIVMIFTYYRIYLEA-----------------------KREHKAAKTLGIIMGAFILCWLP 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444 250 LHILNCITLFC-PTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15066 215 FFLWYVTTTLCgDACPYPPILVSILFWIGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
15-299 1.68e-22

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 94.69  E-value: 1.68e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILI------NIGPqtyfHTCLMVACPVL 88
Cdd:cd15049   6 ATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYlvmgywPLGP----LLCDLWLALDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  89 ILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSeveqawianGSVGEPVIK 168
Cdd:cd15049  82 VASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGWQYFV---------GERTVPDGQ 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 169 CEFEKVISmeymVYFNFfvwvlppLLLMVLIYLEVFYLIrkQLNKKVSASSgdpqkyyGKELKIAKSLALILFLFALSWL 248
Cdd:cd15049 153 CYIQFLDD----PAITF-------GTAIAAFYLPVLVMT--ILYWRIYRET-------ARERKAARTLSAILLAFIITWT 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444 249 PLHILNCITLFCPTCqKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15049 213 PYNILVLVSTFCAKC-IPDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
18-299 2.63e-22

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 94.48  E-value: 2.63e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQ-TYFHT-CLMVACPVLILTQSSI 95
Cdd:cd15056   9 LVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRwIYGETfCLVRTSLDVLLTTASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLR-VKIPLRYKtvVTQRRAAVAIAGCWILSLVVGLTP-MFGWNNLSeVEQAWIANGSVGEPVikCEFek 173
Cdd:cd15056  89 MHLCCIALDRYYAiCCQPLVYK--MTPLRVAVMLGGCWVIPTFISFLPiMQGWNHIG-IEDLIAFNCASGSTS--CVF-- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 VISMEYMV---YFNFFVWVLPPLLLMVLIYL---EVFYLIRKQLNKKVSASSGDPQK--YYGKELKIAKSLALILFLFAL 245
Cdd:cd15056 162 MVNKPFAIicsTVAFYIPALLMVLAYYRIYVaarEQAHQIRSLQRAGSSNHEADQHRnsRMRTETKAAKTLGIIMGCFCV 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 56699444 246 SWLPLHILNCITLFCPTcQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15056 242 CWAPFFVTNIVDPFIGY-RVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
18-299 6.75e-22

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 93.82  E-value: 6.75e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTC---LMVACPVLILTqSS 94
Cdd:cd15959   9 LAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTvceLWTSVDVLCVT-AS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTP-MFGWNNLSEVEQawiANGSVGEPVIkCEFek 173
Cdd:cd15959  88 IETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPiMNQWWRDGADEE---AQRCYDNPRC-CDF-- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 VISMEYMVY---FNFFVwvlpPLLLMVLIYLEVFY-------LIRKQL----------NKKVSASSGDPQKYYG-KELKI 232
Cdd:cd15959 162 VTNMPYAIVsstVSFYV----PLLVMIFVYVRVFVvatrqvrLIRKDKvrfppeesppAESRPACGRRPSRLLAiKEHKA 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56699444 233 AKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAiFLTHGNSAMNPIVYAfRIHKFRVTF 299
Cdd:cd15959 238 LKTLGIIMGTFTLCWLPFFVANIIKVFCRSLVPDPAFLFLN-WLGYANSAFNPIIYC-RSPDFRSAF 302
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
18-299 1.19e-21

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 92.34  E-value: 1.19e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINI--GPQTYFHTC--LMVACPVLILTqS 93
Cdd:cd15310   9 ALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVtgGVWNFSRICcdVFVTLDVMMCT-A 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQ---RRAAVAIAGCWILSLVVGLTPMFGWNnlseveqawiangSVGEPVIkCE 170
Cdd:cd15310  88 SILNLCAISIDRYTAVVMPVHYQHGTGQsscRRVSLMITAVWVLAFAVSCPLLFGFN-------------TTGDPTV-CS 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 171 FEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFylirkqlnkkvsassgdpqkyygKELKIAKSLALILFLFALSWLPL 250
Cdd:cd15310 154 ISNPDFVIYSSVVSFYLPFGVTLLVYVRIYVVLL-----------------------REKKATQMLAIVLGAFIVCWLPF 210
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56699444 251 HILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15310 211 FLTHILNTHCQACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
18-299 1.30e-21

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 92.75  E-value: 1.30e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIlinigPQTYFHTCLM--VACPVLI-----L 90
Cdd:cd15048   9 VLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYI-----PYTLTGKWPFgkVFCKAWLvvdytL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  91 TQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAwiangsvgePVIKCE 170
Cdd:cd15048  84 CTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWDLWTGYSIV---------PTGDCE 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 171 FEKVISMEY---MVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVS----------ASSGDPQKYYGKELKIAKSLA 237
Cdd:cd15048 155 VEFFDHFYFtfiTSVLEFFIPFISVSFFNLLIYLNIRKRSRRRPLRSVPilpasqnpsrARSQREQVKLRRDRKAAKSLA 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56699444 238 LILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15048 235 ILVLVFLICWAPYTILTIIRSFCSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
21-299 1.06e-20

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 89.65  E-value: 1.06e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  21 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFH--TC-LMVACPVLILTqSSILA 97
Cdd:cd15330  12 LCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGqvTCdLFIALDVLCCT-SSILH 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  98 LLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAwiangsvgepvIKCEFEKviSM 177
Cdd:cd15330  91 LCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPEDRSDP-----------DACTISK--DP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 178 EYMVYFNFFVWVLPPlllmvlIYLEVFYlirkqlnkkvsassGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCIT 257
Cdd:cd15330 158 GYTIYSTFGAFYIPL------ILMLVLY--------------GRIFKAAARERKTVKTLGIIMGTFILCWLPFFIVALVL 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 56699444 258 LFC-PTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15330 218 PFCeSTCHMPELLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
13-299 1.54e-20

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 89.20  E-value: 1.54e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  13 IGIEVLIA---LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPV 87
Cdd:cd15327   1 VGVGVFLAifiLMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRvfCDIWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  88 LILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNnlseveqawiangsvgEPVI 167
Cdd:cd15327  81 VLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWK----------------EPPP 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 168 KCEFEKVISME--YMVYFNFFVWvLPPLLLMVLIYLEVFYLIRKqlnkkvsassgdpqkyYGKELKIAKSLALILFLFAL 245
Cdd:cd15327 145 PDESICSITEEpgYALFSSLFSF-YLPLMVILVMYFRVYVVALK----------------FSREKKAAKTLAIVVGVFIL 207
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444 246 SWLPLHILNCITLFCPTCqKPSILIYIAIF-LTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15327 208 CWFPFFFVLPLGSFFPAL-KPSEMVFKVIFwLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
15-299 1.68e-20

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 89.11  E-value: 1.68e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPL---AILINIGPQTYfHTCLMVACPVLILT 91
Cdd:cd15301   6 VAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLftvYTALGYWPLGY-EVCDTWLAIDYLAS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  92 QSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSeveqawianGSVGEPVIKCEF 171
Cdd:cd15301  85 NASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPWIYSWPYIE---------GKRTVPAGTCYI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 172 EKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKkvsassgdpqkyygKELKIAKSLALILFLFALSWLPLH 251
Cdd:cd15301 156 QFLETNPYVTFGTALAAFYVPVTIMCILYWRIWRETKKRQKK--------------QESKAAKTLSAILLAFIVTWTPYN 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56699444 252 ILNCITLFCPTCQK-PSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15301 222 VLVLIKAFFPCSDTiPTELWDFSYYLCYINSTINPLCYALCNAAFRRTY 270
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
10-299 2.58e-20

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 88.35  E-value: 2.58e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVsVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIgpQTYFHTCLMVACPVLI 89
Cdd:cd15308   2 AALVGGVLLILAI-IAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEF--QGGVWTLSPVLCDALM 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 -----LTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAwiangsvge 164
Cdd:cd15308  79 tmdvmLCTASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNRDPA--------- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 165 pviKCEFEKVISMEYMVYFNFFVwvlpplllMVLIYLEVFYLIRKQLnkkvsassgdpqkyyGKELKIAKSLALILFLFA 244
Cdd:cd15308 150 ---VCKLEDNNYVVYSSVCSFFI--------PCPVMLVLYCAMFRGL---------------GRERKAMRVLPVVVGAFL 203
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444 245 LSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15308 204 FCWTPFFVVHITRALCESCSIPPQLISIVTWLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
11-299 2.62e-20

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 88.49  E-value: 2.62e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  11 AYIGIEV-LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAilinigpQTYF---HTCL-MVAC 85
Cdd:cd17790   1 VLIVITTgILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLY-------TTYIlmgHWALgTVAC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  86 PV-----LILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLseVEQAWIANG 160
Cdd:cd17790  74 DLwlaldYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYL--VGERTVLAG 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 161 S-----VGEPVIKceFEKVISMeymvyfnFFVWVLPPLLLMVLIYLEVFylirkqlnkkvsassgdpqkyygKELKIAKS 235
Cdd:cd17790 152 QcyiqfLSQPIIT--FGTAIAA-------FYLPVTIMIILYWRIYRETI-----------------------KEKKAART 199
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56699444 236 LALILFLFALSWLPLHILNCITLFCPTCQkPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd17790 200 LSAILLAFILTWTPYNIMVLVSTFCKDCV-PKTLWELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
18-299 3.17e-20

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 89.29  E-value: 3.17e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRD-ATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT-CLMVACPVLILTQSSI 95
Cdd:cd15320  10 VLILSTLLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSfCNIWVAFDIMCSTASI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPM-FGWNNLSEVEQAWIANGSVGEPVIKCefEKV 174
Cdd:cd15320  90 LNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVqLNWHKAKPTSFLDLNASLRDLTMDNC--DSS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 175 ISMEYMV---YFNFFVwvlpPLLLMVLIYLEVFYLIRKQLnKKVSA------------------SSGDPQK-------YY 226
Cdd:cd15320 168 LNRTYAIsssLISFYI----PVAIMIVTYTRIYRIAQKQI-RRISAleraavhakncqnstgnrGSGDCQQpessfkmSF 242
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56699444 227 GKELKIAKSLALILFLFALSWLPLHILNCITLFC-PTCQKP----SILIYIAIFLTHGNSAMNPIVYAFRIhKFRVTF 299
Cdd:cd15320 243 KRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCkPTSTEPfcisSTTFDVFVWFGWANSSLNPIIYAFNA-DFRKAF 319
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
18-299 7.33e-20

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 87.55  E-value: 7.33e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSSI 95
Cdd:cd15054   9 LIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARdfCPIWYAFDVMCCSASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPM-FGWNNLSevEQAWIANGSVGEPVIKCEFekV 174
Cdd:cd15054  89 LNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIeLGWHELG--HERTLPNLTSGTVEGQCRL--L 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 175 ISMEYMVY---FNFFVWVLPPLLLMVLIYLEVFylirkqlnkkvsassgdpqkyygKELKIAKSLALILFLFALSWLPLH 251
Cdd:cd15054 165 VSLPYALVascLTFFLPSGAICFTYCRILLAAR-----------------------KALKASLTLGILLGMFFVTWLPFF 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56699444 252 ILNCITLFCPTCqkPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15054 222 VANVVQAVCDCV--SPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
18-299 1.54e-19

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 86.88  E-value: 1.54e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPL-AILINIGPQTY--FHTCLMVACPVLILTqSS 94
Cdd:cd15958   9 LIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFgATLVVRGRWLYgsFFCELWTSVDVLCVT-AS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTP--MFGWNNLSEVEQAWIANGSVgepvikCEFe 172
Cdd:cd15958  88 IETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFLPimMHWWRDEDDQALKCYEDPGC------CDF- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 kVISMEYMV---YFNFFVwvlpPLLLMVLIYLEVFYLIRKQLNK--------------KVSASSGDPQKYYG-KELKIAK 234
Cdd:cd15958 161 -VTNRAYAIassIISFYI----PLLIMIFVYLRVYREAKKQIKKidkcegrfhntltgLGRKCKRRPSRILAlREQKALK 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56699444 235 SLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAiFLTHGNSAMNPIVYAfRIHKFRVTF 299
Cdd:cd15958 236 TLGIIMGVFTLCWLPFFLVNVVNVFNRELVPDWLFVFFN-WLGYANSAFNPIIYC-RSPDFRKAF 298
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
18-299 2.85e-19

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 85.48  E-value: 2.85e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLM-VACPVLILTqSS 94
Cdd:cd15331   9 LLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPevCDMwISMDVLCCT-AS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKiPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGW---NNLSEVEQawiangsvgepVIKCEF 171
Cdd:cd15331  88 ILHLVAIALDRYWAVT-NIDYIRRRTAKRILIMIAVVWFVSLIISIAPLFGWkdeDDLDRVLK-----------TGVCLI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 172 EKVISmeYMVYFN---FFVwvlpPLLLMVLIYLEVFYLIRKqlnkkvsassgdpqkyygkELKIAKSLALILFLFALSWL 248
Cdd:cd15331 156 SQDYG--YTIFSTvgaFYV----PLLLMIIIYWKIYQAAKR-------------------ERKAARTLAIITGAFVVCWL 210
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444 249 PLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15331 211 PFFLVALVMPFCGAWQISRFLESFFLWLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
17-299 6.40e-19

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 85.18  E-value: 6.40e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAiLINIGPQTYFH---TCLMVACPVLILTQS 93
Cdd:cd14992   8 VVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFN-FTYVVSLSWEYghfLCKIVNYLRTVSVYA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFgwnnLSEVEQAWIANGSVGEPVikCEFEK 173
Cdd:cd14992  87 SSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLY----YATTEVLFSVKNQEKIFC--CQIPP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 VISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYY--GKELKIAKSLALILFLFALSWLPLH 251
Cdd:cd14992 161 VDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKVPGFSIKEVERKrlKCKRRVIKMLVCVVVLFVICWLPFH 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444 252 ILNCITLFCPTCQKPS---ILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd14992 241 LFFLLRDFFPLIMKEKhtlQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
15-302 8.26e-19

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 84.62  E-value: 8.26e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQ 92
Cdd:cd15307   6 LALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSehCLTWICLDVLFCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWnnlSEVEQAWIANGSVGEPVikcEFE 172
Cdd:cd15307  86 ASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMY---SKDHASVLVNGTCQIPD---PVY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 KVISMEYMVYFNFfvwvlpplllmvLIYLEVFYLIRKQLNKKvsassgdpQKYYGK----ELKIAKSLALILFLFALSWL 248
Cdd:cd15307 160 KLVGSIVCFYIPL------------GVMLLTYCLTVRLLARQ--------RSRHGRiirlEQKATKVLGVVFFTFVILWS 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444 249 PLHILNCITLFCPTCQK--PSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKI 302
Cdd:cd15307 220 PFFVLNLLPTVCAECEEriSHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKV 275
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
13-297 3.07e-18

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 83.15  E-value: 3.07e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  13 IGIEVLIA-LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTCLMVACPVLI 89
Cdd:cd15083   3 LGIFILIIgLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFgkTGCDMYGFSGGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 LTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNnlseveqAWIANGSvgepVIKC 169
Cdd:cd15083  83 FGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWS-------RYVLEGL----LTSC 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 EFEKV----ISMEYMVYFNFFVWVLPPLLLMVLiYLEVFYLIRK-------QLNKKVSASSGDPQKYYGKELKIAKSLAL 238
Cdd:cd15083 152 SFDYLsrddANRSYVICLLIFGFVLPLLIIIYC-YSFIFRAVRRhekamkeMAKRFSKSELSSPKARRQAEVKTAKIALL 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56699444 239 ILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRV 297
Cdd:cd15083 231 LVLLFCLAWTPYAVVALIGQFGYLEVLTPLATAIPAAFAKTSAIYNPVIYAFSHPKFRR 289
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
18-296 3.49e-18

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 82.98  E-value: 3.49e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF-------HTCLMVAcpvliL 90
Cdd:cd15316   9 FGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFgesfctfHTCCDVS-----F 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  91 TQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPVIKCE 170
Cdd:cd15316  84 CYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFYTGVNDDGLEELVNALNCVGGCQIILN 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 171 FEKVISMEYMVYFNFFVwvlpplllMVLIYLEVFYLIRKQL-------NKKVSASSGDPQKYYGKELKIAKSLALILFLF 243
Cdd:cd15316 164 QNWVLVDFLLFFIPTFA--------MIILYGKIFLVAKQQArkiemtsSKAESSSESYKDRVARRERKAAKTLGITVIAF 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56699444 244 ALSWLPLHILNCITLFCPTCqKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15316 236 LVSWLPYLIDVLIDAFMNFI-TPPYIYEICCWCAYYNSAMNPLIYALFYPWFR 287
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
18-299 5.79e-18

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 82.33  E-value: 5.79e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTCLMVACPVLILTQSSI 95
Cdd:cd15095   9 IIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFgdFMCKFVNYMMQVTVQATC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFgwnNLSEVEQAWiangsvGEPVIKCE----- 170
Cdd:cd15095  89 LTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAI---YYRLEEGYW------YGPQTYCRevwps 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 171 --FEKVismeYMVYfNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWL 248
Cdd:cd15095 160 kaFQKA----YMIY-TVLLTYVIPLAIIAVCYGLILRRLWRRSVDGNNQSEQLSERALRQKRKVTRMVIVVVVLFAICWL 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 56699444 249 PLHILNCITLFCPTCQKPSILIYI---AIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15095 235 PNHVLNLWQRFDPNFPETYATYALkiaALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
18-299 8.16e-18

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 81.92  E-value: 8.16e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPL--AILINIGPQTYFHTCLMVACPVLILTQSSI 95
Cdd:cd15299  12 ILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLftTYIIMNRWALGNLACDLWLSIDYVASNASV 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWnnlseveQAWIANGSV--GEPVIKCEFEK 173
Cdd:cd15299  92 MNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFW-------QYFVGKRTVppDECFIQFLSEP 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 VISMEYMVYfNFFVWVLPPLLLMVLIYLEVFylirkqlnkkvsassgdpqkyygKELKIAKSLALILFLFALSWLPLHIL 253
Cdd:cd15299 165 IITFGTAIA-AFYLPVTIMTILYWRIYKETI-----------------------KEKKAAQTLSAILLAFIITWTPYNIM 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 56699444 254 NCITLFCPTCqKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15299 221 VLVNTFCDSC-IPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTF 265
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
17-309 1.78e-17

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 80.72  E-value: 1.78e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAiLINIgPQTYFHTCLMVACPVLI-----LT 91
Cdd:cd15305   8 LIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVS-LIAI-LYDYAWPLPRYLCPIWIsldvlFS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  92 QSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL-TPMFGWNNLSEVeqawIANGSVgepvikce 170
Cdd:cd15305  86 TASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMpIPVIGLQDDEKV----FVNGTC-------- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 171 fekVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKqlnkkvsassgdpQKYYGKELKIAKSLALILFLFALSWLPL 250
Cdd:cd15305 154 ---VLNDENFVLIGSFVAFFIPLIIMVITYCLTIQVLQR-------------QQAINNERRASKVLGIVFFLFLIMWCPF 217
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56699444 251 HILNCITLFCP-TCQKP--SILIYIAIFLTHGNSAMNPIVYAFrihkFRVTFLKIWNDHFRC 309
Cdd:cd15305 218 FITNILSVLCKeACDQKlmEELLNVFVWVGYVSSGINPLVYTL----FNKTYRRAFSNYIRC 275
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
13-299 1.96e-17

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 81.28  E-value: 1.96e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  13 IGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTclmVACPVLILTQ 92
Cdd:cd15208   4 IALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQ---VLCKIIPYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 S-----SILALLAIAVDRYLRVKIPLRYKTvvTQRRAAVAIAGCWILSLVVG--------LTPMFGWNN----LSEVEQA 155
Cdd:cd15208  81 TvsvsvSVLTLSCIALDRWYAICHPLMFKS--TAKRARVSILIIWIVSLLIMipqaivmeCSRVVPLANktilLTVCDER 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 156 WiaNGSVGEPVIKCEFEKVISMEYMV-----YFNFFV--WvlpplllMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGK 228
Cdd:cd15208 159 W--SDSIYQKVYHICFFLVTYLLPLClmilaYFQIFRklW-------CRQIPGTSSVVQRKWNKPRKSAVAAEEKQLRSR 229
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56699444 229 ElKIAKSLALILFLFALSWLPLHILN----CITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15208 230 R-KTAKMLIVVVIMFAICYLPVHLLNilryVFGLFTVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
18-299 2.83e-17

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 80.77  E-value: 2.83e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALR-DATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT-CLMVACPVLILTQSSI 95
Cdd:cd15319   9 LLILWTLLGNILVCAAVVRFRHLRsKVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAfCDVWVAFDIMCSTASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPM-FGWNNlsEVEQAWIANGSVGEPVIKCE-FEK 173
Cdd:cd15319  89 LNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVqLNWHK--DSGDDWVGLHNSSISRQVEEnCDS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 VISMEYMV---YFNFFVWVLPPLLLMVLIYLEVFYLIRK--------------QLNKKVSASSGDPQKYYGKELKIAKSL 236
Cdd:cd15319 167 SLNRTYAIsssLISFYIPVAIMIVTYTRIYRIAQIQIRRissleraaehaqscRSNRIDCHHHTSLRTSIKKETKVLKTL 246
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56699444 237 ALILFLFALSWLPLHILNCITLFC--PTCQKPSILIYIA-----IFLTHG--NSAMNPIVYAFRIhKFRVTF 299
Cdd:cd15319 247 SVIMGVFVCCWLPFFILNCMVPFCdrPPADPDAGLPCVSettfdVFVWFGwaNSSLNPIIYAFNA-DFRKVF 317
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
17-299 3.54e-17

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 80.18  E-value: 3.54e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSS 94
Cdd:cd15317   8 VLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDlfCKFHTGLDLLLCTTS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPVIKceFEKV 174
Cdd:cd15317  88 IFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTGANDEGLEEYSSEISCVGGCQLL--FNKI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 175 ISMeyMVYFNFFVwvlpPLLLMVLIYLEVFYLIRKQLNK------KVSASSGDPQKYYGK-ELKIAKSLALILFLFALSW 247
Cdd:cd15317 166 WVL--LDFLTFFI----PCLIMIGLYAKIFLVARRQARKiqnmedKFRSSEENSSKASASrERKAAKTLAIVMGIFLFCW 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56699444 248 LPLHILNCITLFCpTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15317 240 LPYFIDTIVDEYS-NFITPAIVFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
17-299 8.89e-17

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 78.82  E-value: 8.89e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIL-INIGPQTYFHTCLmvaCPVLI-----L 90
Cdd:cd15304   8 VIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLtILYGYRWPLPSKL---CAVWIyldvlF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  91 TQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL-TPMFGWNNLSEVeqawIANGSVgepvikc 169
Cdd:cd15304  85 STASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMpIPVFGLQDDSKV----FKEGSC------- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 efekVISMEYMVYFNFFVwvlpPLLLMVLIYLEVFYLIRKQLNKKVSassgdpqkyygKELKIAKSLALILFLFALSWLP 249
Cdd:cd15304 154 ----LLADENFVLIGSFV----AFFIPLTIMVITYFLTIKSLQQSIS-----------NEQKASKVLGIVFFLFVVMWCP 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56699444 250 LHILNCITLFC-PTCQKPSI--LIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15304 215 FFITNVMAVICkESCNEVVIggLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
12-299 2.16e-16

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 77.38  E-value: 2.16e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  12 YIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF---HTCLMVACPVL 88
Cdd:cd15309   3 YAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFsriHCDIFVTLDVM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  89 ILTqSSILALLAIAVDRYLRVKIPLRYKT-VVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQawiangsvgepvi 167
Cdd:cd15309  83 MCT-ASILNLCAISIDRYTAVAMPMLYNTrYSSKRRVTVMISVVWVLSFAISCPLLFGLNNTDQNEC------------- 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 168 kcefekVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRkqlnkkvsassgdpqkyygKELKIAKSLALILFLFALSW 247
Cdd:cd15309 149 ------IIANPAFVVYSSIVSFYVPFIVTLLVYVQIYIVLQ-------------------KEKKATQMLAIVLGVFIICW 203
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56699444 248 LPLHILNCITLFCpTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15309 204 LPFFITHILNMHC-DCNIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
18-299 2.31e-16

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 77.98  E-value: 2.31e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLA---ILINIGPQTYFHTCLMVACPVLILTqSS 94
Cdd:cd15957   9 LIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGaahILLKTWTFGNFWCEFWTSIDVLCVT-AS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPM-FGWNNLSEVEqawiANGSVGEPVIkCEFek 173
Cdd:cd15957  88 IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIqMHWYRATHQE----AINCYAEETC-CDF-- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 VISMEYMV---YFNFFVwvlpPLLLMVLIYLEVFYLIRKQLNK------------------KVSASSGDPQKYYGKELKI 232
Cdd:cd15957 161 FTNQAYAIassIVSFYV----PLVIMVFVYSRVFQEAKRQLQKidksegrfhnqnidqngsGGGGGNRRRSKFCLKEHKA 236
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 233 AKSLALILFLFALSWLPLHILNCITlfcpTCQKPSILIYIAIFLT---HGNSAMNPIVYAfRIHKFRVTF 299
Cdd:cd15957 237 LKTLGIIMGTFTLCWLPFFIVNIVH----VIQDNLIRKEVYILLNwigYVNSGFNPLIYC-RSPDFRIAF 301
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
10-299 2.92e-16

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 77.40  E-value: 2.92e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMvaCPVLI 89
Cdd:cd15392   1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILQYWPFGEFM--CPVVN 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 LTQS-----SILALLAIAVDRYLRVKIPLRYKtvVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEVEQAWIANGSVGE 164
Cdd:cd15392  79 YLQAvsvfvSAFTLVAISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIFALATAL-PIAITSRLFEDSNASCGQYICTE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 165 PVIKCEFEKVISMEYMVyFNFFVWVLPPLLLMVLIylevfylIRKQLNKKV--SASSGDPQKYYGKELKIAKSLALILFL 242
Cdd:cd15392 156 SWPSDTNRYIYSLVLMI-LQYFVPLAVLVFTYTRI-------GIVVWAKRTpgEAENNRDQRMAESKRKLVKMMITVVAI 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 243 FALSWLPLHILNCITLFCPTCQKPSILIYI---AIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15392 228 FALCWLPLNILNLVGDHDESIYSWPYIPYLwlaAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
19-299 3.66e-16

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 76.93  E-value: 3.66e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  19 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLA---ILINIGPQTYFHTCLMVACPvLILTQSSI 95
Cdd:cd15297  10 LSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYtlyTVIGYWPLGPVVCDLWLALD-YVVSNASV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSeveqawianGSVGEPVIKCefekvi 175
Cdd:cd15297  89 MNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV---------GGRTVPEGEC------ 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 176 smeymvYFNFFvwvlPPLLLMVLIYLEVFYL---IRKQLNKKVSASSgdpqkyyGKELKIAKSLALILFLFALSWLPLHI 252
Cdd:cd15297 154 ------YIQFF----SNAAVTFGTAIAAFYLpviIMTVLYWQISRAS-------SREKKVTRTILAILLAFIITWTPYNV 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56699444 253 LNCITLFCPTCqKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15297 217 MVLINTFCASC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
10-299 4.47e-16

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 76.98  E-value: 4.47e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIevlIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALV-IPLAILINIGPQTYFHTclmVACPVL 88
Cdd:cd15337   4 GIYIAI---VGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNgFPLKTISSFNKKWIWGK---VACELY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  89 ILTQS-----SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNnlseveqAWIANGSvg 163
Cdd:cd15337  78 GFAGGifgfmSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWG-------RYVPEGF-- 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 164 epVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLI---YLEVFYLIRKQ-------LNKKVSASSGDPQKYYGKELKIA 233
Cdd:cd15337 149 --QTSCTFDYLSRDLNNRLFILGLFIFGFLCPLLIIifcYVNIIRAVRNHekemtqtAKSGMGKDTEKNDARKKAEIRIA 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444 234 KSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15337 227 KVAIILISLFLLSWTPYAVVALLGQFGPAYWITPYVSELPVMFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
18-299 7.12e-16

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 76.35  E-value: 7.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSSI 95
Cdd:cd14971   9 LIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDfmCKFVHYFQQVSMHASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEVEQAWIANGSVGEPVIKCEfekvi 175
Cdd:cd14971  89 FTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAA-PVLALHRLRNYTPGNRTVCSEAWPSRAHR----- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 176 sMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKyygkelKIAKSLALILFLFALSWLPLHILNC 255
Cdd:cd14971 163 -RAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSRRAKR------KVTRLVLVVVVLFAACWGPIHAILL 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 56699444 256 ITLFCPTCQKPS--ILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd14971 236 LVALGPFPLTYAtyALRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
17-299 7.83e-16

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 76.41  E-value: 7.83e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVP---GNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTY-FHTCLmvaCPV----- 87
Cdd:cd15306   5 LLILMVIIPtigGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMWpLPLVL---CPIwlfld 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  88 LILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL-TPMFGwnnlseveqawIANGSVGEPV 166
Cdd:cd15306  82 VLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIpVPIKG-----------IETDVDNPNN 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 167 IKCEFEKVISMEYMVYFN---FFVwvlpPLLLMVLIYLEVFYLIRKQLnkkvsassgdpqkyYGKELKIAKSLALILFLF 243
Cdd:cd15306 151 ITCVLTKERFGDFILFGSlaaFFT----PLAIMIVTYFLTIHALRKQT--------------ITNEQRASKVLGIVFFLF 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 56699444 244 ALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHG--NSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15306 213 LLMWCPFFITNITSVLCDSCNQTTLQMLMEIFVWIGyvSSGVNPLVYTLFNKTFRDAF 270
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
17-299 9.68e-16

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 75.81  E-value: 9.68e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIL-INIGPQTYFHT--CLMVACPVLILTQS 93
Cdd:cd15052   8 LLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILtELFGGVWPLPLvlCLLWVTLDVLFCTA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL-TPMFGWNNLSEVeqawIANGSVGEPvikcefe 172
Cdd:cd15052  88 SIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSpIPVLGIIDTTNV----LNNGTCVLF------- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 kviSMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSAssgdpqkyygkelkiakslaLILFLFALSWLPLHI 252
Cdd:cd15052 157 ---NPNFVIYGSIVAFFIPLLIMVVTYALTIRLLSNEQKASKVLG--------------------IVFAVFVICWCPFFI 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56699444 253 LNCITLFCPTC--QKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15052 214 TNILTGLCEECncRISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
10-299 1.21e-15

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 75.73  E-value: 1.21e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTC---LMVACP 86
Cdd:cd15321   7 AAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTwceIYLALD 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  87 VLILTqSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNlSEVEQAwiangsvGEPv 166
Cdd:cd15321  87 VLFCT-SSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGK-QKDEQG-------GLP- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 167 iKCEF-EKVISMEYMVYFNFFVwvlpPLLLMVLIYLEVfYLIRKQlnkkvsassgdpqkyygKELKIAKSLALILFLFAL 245
Cdd:cd15321 157 -QCKLnEEAWYILSSSIGSFFA----PCLIMILVYLRI-YLIAKN-----------------REKRFTFVLAVVIGVFVL 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444 246 SWLPLHILNCITLFCP-TCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15321 214 CWFPFFFSYSLGAICPeLCKVPHSLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
14-299 1.30e-15

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 75.60  E-value: 1.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  14 GIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVG---ALVIPLAILINIG---PQTYFHTCLMVACPV 87
Cdd:cd15103   5 EVFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSvsnALETIVIILLNNGylvPRDSFEQHIDNVIDS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  88 LILTQ--SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMfgwnnlseveqawIANGSVgeP 165
Cdd:cd15103  85 MICSSllASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFI-------------IYSDSV--P 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 166 VIKCefekVISMEYMVYFnffvwvlppllLMVLIYLEVFYLIRKQLnKKVSASSGDPQKYYGKELKIAKSLALILFLFAL 245
Cdd:cd15103 150 VIIC----LISMFFAMLV-----------LMASLYVHMFLLARSHV-KKIAALPGQRSTRQRANMKGAVTLTILLGVFIF 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56699444 246 SWLPLHILNCITLFCPtcQKPSILIYIAIFLTHG-----NSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15103 214 CWAPFFLHLTLMISCP--SNPYCACYMSHFNVYLilimcNSVIDPLIYAFRSQELRKTF 270
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
21-296 1.38e-15

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 75.67  E-value: 1.38e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  21 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTCLMVACPVLILTQSSILAL 98
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFgdSFCRLHTCLDTLFCLTSIFHL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  99 LAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVvgLTPMFGWNN-----LSEVEQAWIANGSVgepvikcefeK 173
Cdd:cd15318  92 CFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTV--YTSVFLYTKaveegLAELLTSVPCVGSC----------Q 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 VISMEYMVYFNFFVWvLPPLLLMVLIYLEVFYLIRKQlNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHIL 253
Cdd:cd15318 160 LLYNKLWGWLNFPVF-FIPCLIMIGLYVKIFIVAKRQ-ARAIASLLSDTNGASKRERKAAKTLGIAVGVYLLCWLPFTID 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 56699444 254 NCITLFCPTCqKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15318 238 TMVDSLLNFI-TPPLLFDIIIWFAYFNSACNPLIYVFSYPWFR 279
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
10-299 1.88e-15

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 75.33  E-value: 1.88e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLmvaCPVLI 89
Cdd:cd15203   1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSIL---CKLVP 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 LTQS-----SILALLAIAVDRYLRVKIPLRYKtvVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEVEQawianGSVGE 164
Cdd:cd15203  78 SLQGvsifvSTLTLTAIAIDRYQLIVYPTRPR--MSKRHALLIIALIWILSLLLSL-PLAIFQELSDVPI-----EILPY 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 165 PVIKCEfEKVISMEYMVYFNFFVWVLPPLLLMVLI---YLEVFYLIRKQLNKK--VSASSGDPQKYYGKEL-KIAKSLAL 238
Cdd:cd15203 150 CGYFCT-ESWPSSSSRLIYTISVLVLQFVIPLLIIsfcYFRISLKLRKRVKKKrgKRTLSSRRRRSELRRKrRTNRLLIA 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56699444 239 ILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTH----GNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15203 229 MVVVFAVCWLPLNLFNLLRDFEPLPQIDGRHFYLIFLICHliamSSACVNPLLYGWLNDNFRKEF 293
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
15-299 2.03e-15

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 74.68  E-value: 2.03e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLA---ILINIGPQTYFHTCLMVACPvLILT 91
Cdd:cd15300   6 VTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYtsyILMGYWALGSLACDLWLALD-YVAS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  92 QSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWnnlseveQAWIANGSVGEPVIKCEF 171
Cdd:cd15300  85 NASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILCW-------QYFVGKRTVPERECQIQF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 172 --EKVISMEYMVYfNFFVWVLPPLLLMVLIYLEVFylirkqlnkkvsassgdpqkyygKELKIAKSLALILFLFALSWLP 249
Cdd:cd15300 158 lsEPTITFGTAIA-AFYIPVSVMTILYCRIYKETI-----------------------KERKAAQTLSAILLAFIITWTP 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444 250 LHILNCITLFCPTCqKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15300 214 YNIMVLVSTFCSDC-IPLTLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
10-299 3.04e-15

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 74.70  E-value: 3.04e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIaLVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF-------HTCLM 82
Cdd:cd15312   2 AMYLFMAGAI-LLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFgdlfckiHSSLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  83 vacpvLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSV 162
Cdd:cd15312  81 -----MMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVFSEVNLEGIEDYVALVSCT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 163 GE-PVIKCEFEKVISmeymvyfnFFVWVLPPLLLMVLIYLEVFYLIRKQ---LNKKVSASSGDPQKYYG--KELKIAKSL 236
Cdd:cd15312 156 GScVLIFNKLWGVIA--------SLIAFFIPGTVMIGIYIKIFFVARKHakvINNRPSVTKGDSKNKLSkkKERKAAKTL 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56699444 237 ALILFLFALSWLPLHILNCITLFCpTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15312 228 SIVMGVFLLCWLPFFVATLIDPFL-NFSTPVDLFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
17-144 3.81e-15

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 73.75  E-value: 3.81e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSS 94
Cdd:cd15324   8 VVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGStwCAFYLALDVLFCTSS 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMF 144
Cdd:cd15324  88 IVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLL 137
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
6-296 4.35e-15

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 74.05  E-value: 4.35e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444   6 SAFQAAYIGIEVLIALvsvpGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGAlviplAILINI---GPQTYFHT--- 79
Cdd:cd15349   1 GALTVLFICISVLIIL----ENLLVLLAILRRVRLRRWVYICLANIALSDLLTGT-----SYLVNIclsGERTFRLTpal 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  80 CLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLseveqawian 159
Cdd:cd15349  72 WFLREGLLFTALAASTFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPLLGWNCL---------- 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 160 gsvgepvikCEFEKVISM--EYMVYFNFF--VWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDpqkyygKELKIAKS 235
Cdd:cd15349 142 ---------CDFRSCSSLlpLYSKSYILFclVIFFIILLTIIGLYFAIYCLVRASGQRVISARSRR------RSLRLLKT 206
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56699444 236 LALILFLFALSWLPLHILNCITLFC--PTCQKPSILIYIaIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15349 207 VLMILGAFMVCWGPLFILLLVDFFCssRSCKPLFGMEWV-LALAVLNSAINPLIYSFRSLEVR 268
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
18-299 4.35e-15

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 74.25  E-value: 4.35e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFH--TCLMVACPVLILTQSSI 95
Cdd:cd15096   9 LIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGdvWCKIVQYLVYVTAYASV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSeveqawiaNGSVGEPVIKCEFEKVI 175
Cdd:cd15096  89 YTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVS--------YGFSSEAYSYCTFLTEV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 176 SMEYMVYF-NFFVWVLPP-LLLMVLIYLEVFYLIRKQL--NKKVSASSGDPQKyygkelKIAKSLALILFLFALSWLPLH 251
Cdd:cd15096 161 GTAAQTFFtSFFLFSYLIpLTLICVLYMLMLRRLRRQKspGGRRSAESQRGKR------RVTRLVVVVVVVFAICWLPIH 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56699444 252 ILNCITLFcptCQKPSILIYIAI-----FLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15096 235 IILLLKYY---GVLPETVLYVVIqilsnCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
18-298 5.31e-15

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 73.98  E-value: 5.31e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTCLMVACPVLILTQSSI 95
Cdd:cd15336   9 IIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFgeKGCELYAFCGALFGITSM 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNnlseveqAWIANGSvgepVIKCEFEKVI 175
Cdd:cd15336  89 ITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWS-------AYVPEGL----LTSCTWDYMT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 176 S-MEYMVY------FNFFVwvlpPLLLMVLIYLEVFYLIRK------QLNKKVSASSGDPQKYYGKELKIAKSLALILFL 242
Cdd:cd15336 158 FtPSVRAYtmllfcFVFFI----PLGIIIYCYLFIFLAIRStgrevqKLGSQDRKEKAKQYQRMKNEWKMAKIAFVVILL 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56699444 243 FALSWLPlhiLNCITLFCPTCQKPSILIY---IAIFLTHGNSAMNPIVYAFRIHKFRVT 298
Cdd:cd15336 234 FVLSWSP---YACVALIAWAGYAHLLTPYmksVPAVIAKASAIYNPIIYAITHPKYREA 289
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
11-286 5.70e-15

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 74.00  E-value: 5.70e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  11 AYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLIL 90
Cdd:cd14977   2 VIMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  91 TQ--SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWnnlsEVEQAWIANGSVGEPVIK 168
Cdd:cd14977  82 TSlgVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLS----TVARESSLDNSSLTVCIM 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 169 cefeKVISMEYMVYFNFFVWVLPPLLLMVLIYLEV--FYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALS 246
Cdd:cd14977 158 ----KPSTPFAETYPKARSWWLFGCYFCLPLAFTAvcYLLMARTLIRAAKEYTRGTKKHMKQRRQLAKTVLCLVLVFAFC 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 56699444 247 WLPLHILNCITLF------CPTCQKPSILIYIAIFLTHGNSAMNPI 286
Cdd:cd14977 234 WLPEHISNILRATlynevlIDTRSTLDILDLIGQFLSFFNSCVNPI 279
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
18-299 6.32e-15

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 73.44  E-value: 6.32e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTC---LMVACPVLILTqSS 94
Cdd:cd15322   9 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVwceIYLALDVLFCT-SS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSeveqawianGSVGEPVIKCEFEK- 173
Cdd:cd15322  88 IVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKS---------GQPEGPICKINDEKw 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 -VISMEYMVYFnffvwvlPPLLLMVLIYLEVFYLIRKqlnkkvsassgdpqkyygKELKIAKSLALILFLFALSWLPLHI 252
Cdd:cd15322 159 yIISSCIGSFF-------APCLIMVLVYIRIYQIAKN------------------REKRFTFVLAVVIGVFVICWFPFFF 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56699444 253 LNCITLFCpTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15322 214 TYTLTAVC-DCSVPETLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
17-299 1.43e-14

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 72.71  E-value: 1.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIL-INIGPQTYF--HTCLMVACPVLILTQS 93
Cdd:cd14997   8 GVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVeTWAREPWLLgeFMCKLVPFVELTVAHA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEveqawiANGSVGEPVIKCEFE- 172
Cdd:cd14997  88 SVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSS-PVLFITEFKE------EDFNDGTPVAVCRTPa 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 -KVISMEY--MVYFNFFVwvlpplllMVLIYLEVFY-LIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSW- 247
Cdd:cd14997 161 dTFWKVAYilSTIVVFFV--------VPLAILSGLYsVICRRLVGHPALESRRADAANRHTLRSRRQVVYMLITVVVLFf 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56699444 248 ---LPLHILNCITLFCPTCQKPS-------ILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd14997 233 vclLPFRVVTLWIIFAPDEDLQAlglegylNLLVFCRVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
19-299 1.81e-14

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 71.97  E-value: 1.81e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  19 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIgpQTYFH----TCLMVACPVLILTQSS 94
Cdd:cd15298  10 LSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYII--KGYWPlgavVCDLWLALDYVVSNAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWnnlseveQAWIANGSVGEPVIKCEFEKV 174
Cdd:cd15298  88 VMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFW-------QFVVGKRTVPDNQCFIQFLSN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 175 ISMEYMVYFNFFvwvlpplllmvliYLEVfyLIRKQLNKKVSASSgdpqkyyGKELKIAKSLALILFLFALSWLPLHILN 254
Cdd:cd15298 161 PAVTFGTAIAAF-------------YLPV--VIMTVLYIHISLAS-------ARERKVTRTIFAILLAFILTWTPYNVMV 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56699444 255 CITLFCPTCqKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15298 219 LVNTFCQSC-IPDTVWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
13-299 1.87e-14

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 72.37  E-value: 1.87e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  13 IGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLaiLINIGPQT---YFHTCLMVACPVLI 89
Cdd:cd15344   4 MGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYL--MFNTGPNTrrlTVSTWLLRQGLIDT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 LTQSSILALLAIAVDRYLRVkIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAwiangsvgepvikC 169
Cdd:cd15344  82 SLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENC-------------S 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 EFEKVISMEYMVYFNFFvwVLPPLLLMVLIYLEVFYLIRkQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLP 249
Cdd:cd15344 148 NMAPLYSDSYLVFWAIF--NLVTFVVMVVLYAHIFGYVR-QRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56699444 250 LHILNCITLFCPTCqkpSILIYIAIF--LTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15344 225 GLVLLLLDVCCPQC---DVLAYEKFFllLAEFNSAMNPIIYSYRDKEMSATF 273
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
19-299 6.00e-14

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 71.00  E-value: 6.00e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  19 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP---LAILIN--IGPQTYFHTCLMV-ACPVLIltq 92
Cdd:cd15202  10 IIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPftfVRAVNNtwIFGLFMCHFSNFAqYCSVHV--- 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 sSILALLAIAVDRYLRVKIPLRYKTvvTQRRAAVAIAGCWILSLVVGLTpmfgwnnlseveQAWIAngSVGEPVIKCEFE 172
Cdd:cd15202  87 -SAYTLTAIAVDRYQAIMHPLKPRI--SKTKAKFIIAVIWTLALAFALP------------HAICS--KLETFKYSEDIV 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 KVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLI-----RKQLNKKVSASSGDPQ--KYYG---KELKIAKSLALILFL 242
Cdd:cd15202 150 RSLCLEDWPERADLFWKYYDLALFILQYFLPLLVIsfayaRVGIKLWASNMPGDATteRYFAlrrKKKKVIKMLMVVVVL 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56699444 243 FALSWLPLHILNCI-TLFCPTCQKPSILIYIAI-FLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15202 230 FALCWLPFNIYVLLlSSKPDYLIKTINAVYFAFhWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
15-299 8.63e-14

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 70.16  E-value: 8.63e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTY---FHTCLMVACPVLILT 91
Cdd:cd15302   6 ITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNGDYWplgWVLCDLWLSVDYTVC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  92 QSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWnnlseveQAWIANGSVGEPViKCef 171
Cdd:cd15302  86 LVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIFGW-------QYFTGQGRSLPEG-EC-- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 172 ekviSMEYMV--YFNfFVWVLPPLLLMVLIYLEVFYLIRKQLNKKvsassgdpqkyygkeLKIAKSLALILFLFALSWLP 249
Cdd:cd15302 156 ----YVQFMTdpYFN-MGMYIGYYWTTLIVMLILYAGIYRAANRA---------------RKALRTITFILGAFVICWTP 215
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56699444 250 LHILNCITLFC--PTCQkPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15302 216 YHILATIYGFCeaPPCV-NETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
11-299 1.19e-13

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 69.83  E-value: 1.19e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  11 AYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGalVIPLAILINIGPQTY---FHTCLMVACPV 87
Cdd:cd15342   2 AVVALGLTVSVIVLLTNLLVIAAIFINRRFHYPIYYLLGNLAAADLFAG--VAYLFLMFHTGPWTAklsLYQWFLRQGLL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  88 LILTQSSILALLAIAVDRYLRVkIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEqawiaNGSVGEPVI 167
Cdd:cd15342  80 DTSLTASVANLLAIAVERHQTI-FTMQLHSKMSNQRVVILIFGIWMVALILGLIPAMGWNCLCDLK-----RCSTMAPLY 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 168 KCEFEKVISMEYMVYFNFFVwvlpplllmvLIYLEVFYLIRKQLnKKVSASSGDPQKYYGKELKIAKSLALILFLFALSW 247
Cdd:cd15342 154 SRSYLVFWALSNLLTFLIMV----------AVYTRIFIYVRRKS-QRMSEHHSSHPRYRETVLGLMKTVVIILGAFVVCW 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56699444 248 LP-LHILNCITLFCPTCQKPSILIYIaIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15342 223 TPgQVVLLLDGLGCESCNVLAYEKYF-LLLAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
13-299 1.29e-13

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 69.97  E-value: 1.29e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  13 IGIEVLIAL--VSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVG------ALVIPLAILINIGPQTYF--HTCLM 82
Cdd:cd15354   2 IAAEVFLTLgiISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSvsnaweTITIYLLNNRHLVIEDAFvrHIDNV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  83 VACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNlseveqawiangsv 162
Cdd:cd15354  82 FDSLICISVVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGIIFILYSES-------------- 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 163 gEPVIKCefekVISMEYMVYFnffvwvlppllLMVLIYLEVFYLIRKQLnKKVSASSGDPQKYYGKELKIAKSLALILFL 242
Cdd:cd15354 148 -TYVIIC----LITMFFAMLF-----------LMVSLYIHMFLLARTHV-KRIAALPGYNSVRQRTSMKGAVTLTILLGI 210
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444 243 FALSWLPLHILNCITLFCPTCqkpsilIYIAIFLTH---------GNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15354 211 FIVCWAPFFLHLILMISCPQN------LYCVCFMSHfnmylilimCNSVIDPLIYAFRSQEMRKTF 270
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
10-143 1.39e-13

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 69.58  E-value: 1.39e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVsvpGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTC---LMVACP 86
Cdd:cd15323   4 AAVVGFLIVFTIV---GNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVwcnIYLALD 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 56699444  87 VLILTqSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPM 143
Cdd:cd15323  81 VLFCT-SSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPL 136
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
15-299 1.43e-13

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 70.08  E-value: 1.43e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINI--------GPQTYFHTCLMVACp 86
Cdd:cd14979   6 IYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWwqypwafgDGGCKLYYFLFEAC- 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  87 vlilTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL--TPMFGWNNLSEVEQAWIANGSVGE 164
Cdd:cd14979  85 ----TYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIpiLFLMGIQYLNGPLPGPVPDSAVCT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 165 PVIKCEFEKvismeYMVYFNFFVWVLPPLLLMVLIYLevfyLIRKQLNKKV-SASSGDPQKYYGKEL--------KIAKS 235
Cdd:cd14979 161 LVVDRSTFK-----YVFQVSTFIFFVLPMFVISILYF----RIGVKLRSMRnIKKGTRAQGTRNVELslsqqarrQVVKM 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 56699444 236 LALILFLFALSWLPLHILNCITLFCPTCQKPSILIY-----IAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd14979 232 LGAVVIAFFVCWLPFHAQRLMFSYASKEDTFLFDFYqylypISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
11-299 1.46e-13

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 69.81  E-value: 1.46e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  11 AYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTCLMVACPVL 88
Cdd:cd15205   2 AFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGgaFMCKMVPFVQS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  89 ILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGlTPMFgwnnlsEVEQAWIANGSVGEPVIK 168
Cdd:cd15205  82 TAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVG-SPML------FVQQLEVKYDFLYEKRHV 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 169 CEFEKVISMEYM---VYFNFFVWVLPPLLLMVLIYLEVFYlirKQLNKKVSASSGDPQKYYGKEL-KIA-------KSLA 237
Cdd:cd15205 155 CCLERWYSPTQQkiyTTFILVILFLLPLTTMLFLYSRIGY---ELWIKKRVGDASVLQTIHGIEMsKISrkkkravKMMV 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56699444 238 LILFLFALSWLPLH---ILNCITLFCPTCQKPSILIYIAIFLTHG--NSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15205 232 TVVLLFAVCWAPFHvvhMMIEYSNLENKYDGVTIKLIFAIVQLIGfsNSFNNPIVYAFMNENFKKNF 298
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
19-299 2.86e-13

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 68.65  E-value: 2.86e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  19 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVG---ALVIPLAILINIG---PQTYFHTCLMVACPVLILTQ 92
Cdd:cd15350  10 IAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSlykTLENILIILADMGylnRRGPFETKLDDIMDSLFCLS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 --SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSlvvgltpmfgwnnlseveqawianGSVGEPVIKCE 170
Cdd:cd15350  90 llGSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFC------------------------GGSGILMILFF 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 171 FEKVISMEYMVYFnffvwvLPPLLLMVLIYLEVFYLIRKQlNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLP- 249
Cdd:cd15350 146 HFVATVICFTVLF------FLMLVLILCLYVHMFLLARSH-ARKIASLPNHHAQHQRSNMRGAITLTILLGVFVCCWAPf 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444 250 -LHILncITLFCPtcQKPSILIYIAIFLTHG-----NSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15350 219 vLHLL--LMMFCP--MNPYCACYRSLFQVNGtlimsHAVIDPAIYAFRSPELRNTF 270
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
18-140 3.34e-13

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 68.97  E-value: 3.34e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPL----AILinigpQTYFHTCLMVACPVLILTQS 93
Cdd:cd15393   9 IISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFqfqaALL-----QRWVLPRFMCPFCPFVQVLS 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 ---SILALLAIAVDRYLRVKIPLRYKtvVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15393  84 vnvSVFTLTVIAVDRYRAVIHPLKAR--CSKKSAKIIILIIWILALLVAL 131
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
17-296 3.69e-13

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 68.46  E-value: 3.69e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIW-AVKVNQALRDATFcFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTCLMVACPVLILTQS 93
Cdd:cd15074   8 TVIGILSTLGNGTVLFvLYRRRSKLKPAEL-LTVNLAVSDLGISVFGYPLAIISAFAHRWLFgdIGCVFYGFCGFLFGCC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPlRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNN-------LSEVEQAWIANGSVGEPV 166
Cdd:cd15074  87 SINTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSygpepfgTSCSIDWTGASASVGGMS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 167 IkcefekVISmeyMVYFNFFVWVLPPLLLMVLIYLEVfylirKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALS 246
Cdd:cd15074 166 Y------IIS---IFIFCYLLPVLIIVFSYVKIIRKV-----KSSRKRVAGFDSRSKRQHKIERKVTKVAVLICAGFLIA 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444 247 WLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15074 232 WTPYAVVSMWSAFGSPDSVPILASILPALFAKSSCMYNPIIYLLFSSKFR 281
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
17-299 4.42e-13

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 68.40  E-value: 4.42e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAV----GALVIPLAILINIGPQTYFHTCLM------VACP 86
Cdd:cd15353   8 VTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVsvsnGSETVVITLLNGNDTDAQSFTVNIdnvidsVICS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  87 VLIltqSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtpMFgwnnlseveqawiangsvgepV 166
Cdd:cd15353  88 SLL---ASICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGV--LF---------------------I 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 167 IKCEFEKVISMEYMVYFNFFVwvlppllLMVLIYLEVFYLIRKQLnKKVSASSGDPQKYYGKELKIAKSLALILFLFALS 246
Cdd:cd15353 142 IYSDSSVVIICLISMFFTMLA-------LMASLYVHMFLLARLHI-KRIAVLPGTGPIRQGANMKGAITLTILLGVFVVC 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 56699444 247 WLPLHILNCITLFCPtcQKPSILIYIAIF-----LTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15353 214 WAPFFLHLIFYISCP--RNPYCVCFMSHFnmyliLIMCNSVIDPLIYAFRSQELRKTF 269
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
17-296 6.54e-13

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 67.78  E-value: 6.54e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTCLMVACPVLILTQSS 94
Cdd:cd15213   8 ILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFgdIFCRISAMLYWFFVLEG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLrvkIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAwiangsvgepvIKCEFEKV 174
Cdd:cd15213  88 VAILLIISVDRYL---IIVQRQDKLNPHRAKILIAVSWVLSFCVSFPPLVGWGKYEFPPRA-----------PQCVLGYT 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 175 ISMEYMVYFNFFVWVLPPLLLMVLIYlEVFYLIRKQLNKKVSAssgdpqkyygkelkiAKSLALILFLFALSWLPLHILN 254
Cdd:cd15213 154 ESPADRIYVVLLLVAVFFIPFLIMLY-SYFCILNTVRSFKTRA---------------FTTILILFIGFSVCWLPYTVYS 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56699444 255 CITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15213 218 LLSVFSRYSSSFYVISTCLLWLSYLKSAFNPVIYCWRIKKFR 259
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
18-302 1.10e-12

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 67.16  E-value: 1.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVL--ILTQSSI 95
Cdd:cd15295   9 LLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIdyLLCTASV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQ-RRAAVAIAGCWILSLVVGlTPMFGWNNLSEVEQAWIANGSVGEP---VIKCEF 171
Cdd:cd15295  89 YNIVLISYDRYQSVSNAVSYRNQQTAtLRIVTQMVAVWVLAFLVH-GPAILVSDSWKTEDGECEPEFFSNWyilAITSVL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 172 EKVISMEYMVYFNFFvwvlpplllmvliyleVFYLIRKQLNKKvsassgdpqkyygkelKIAKSLALILFLFALSWLPLH 251
Cdd:cd15295 168 EFLVPVILVAYFNTQ----------------IYWSLWKRLRDR----------------KLAKSLAIILGTFAICWAPYS 215
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444 252 ILNCITLFCPTcQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKI 302
Cdd:cd15295 216 LFTIIRAACEK-HRGSPWYNFAFWLQWFNSFINPFLYPLCHKRFRKAFLKI 265
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
12-299 1.16e-12

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 66.92  E-value: 1.16e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  12 YIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLI 89
Cdd:cd15001   2 VIIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAflCKAVAYLQLL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 LTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGwnnlSEVEQAWIANGSVGEPVIKC 169
Cdd:cd15001  82 SFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFG----QGLVRYESENGVTVYHCQKA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 EFEKVISMEYMVYfNFFVWVLPPLLLMVLIYlevfylIRKQlnkkvsassgdpqkyygkELKIAKSLALILFLFALSWLP 249
Cdd:cd15001 158 WPSTLYSRLYVVY-LAIVIFFIPLIVMTFAY------ARDT------------------RKQVIKMLISVVVLFAVCWGP 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 56699444 250 LHILNCITLFCPTCQKPSILIYI--AIF--LTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15001 213 LLIDNLLVSFDVISTLHTQALKYmrIAFhlLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
27-299 1.39e-12

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 66.77  E-value: 1.39e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  27 NVLVIWAVKVNQALRDATFCFIVSLAVADVAVGalVIPLAILINIGPQT---YFHTCLMVACPVLILTQSSILALLAIAV 103
Cdd:cd15101  18 NLLVIAAIYKNRRFHFPIYYLLANLAAADFFAG--LAYFFLMFNTGPNTrrlTVSTWFLRQGLLDTSLTASVANLLAIAV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 104 DRYLRVkIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAwiangsvgepvikCEFEKVISMEYMVYF 183
Cdd:cd15101  96 ERHISV-MRMQLHSRLSNRRVVVLIVLVWTMAIVMGAIPSVGWNCLCAIDAC-------------SNMAPLYSRSYLVFW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 184 NFFvwVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPqKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCptC 263
Cdd:cd15101 162 AIS--NLVTFLVMVVVYARIFVYVRRRTNRMSPHTSGSI-RNRDTMMSLLKTVVIVLGAFVVCWTPGLVVLLLDGLC--C 236
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 56699444 264 QKPSILIYIAIF--LTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15101 237 RQCNVLAVEKFFllLAEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
14-298 1.51e-12

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 66.74  E-value: 1.51e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  14 GIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAV-GALVIPLAILINIGpqtyfHTCLMVACPVL---- 88
Cdd:cd15351   5 GLFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVsVSNLIETLFMLLLE-----HGVLVCRAPMLqhmd 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  89 ----ILTQSSILALL----AIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSeveqawiang 160
Cdd:cd15351  80 nvidTMICSSVVSSLsflgAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVYYNSNA---------- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 161 svgepVIKCefekvismeYMVYFNFFVwvlpplLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL 240
Cdd:cd15351 150 -----VILC---------LIVFFLFML------VLMLVLYIHMFILACRHSQSISSQQRRQCPHQQTASLKGAITLTILL 209
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56699444 241 FLFALSWLPLHILNCITLFCPTcqKPSILIYIAIF-----LTHGNSAMNPIVYAFRIHKFRVT 298
Cdd:cd15351 210 GIFFLCWGPFFLHLTLIVTCPT--HPFCLCYFKYFnlfliLIICNSIIDPLIYAFRSQELRKT 270
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
18-299 1.83e-12

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 66.67  E-value: 1.83e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQAL--RDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--------HTCLMVACPV 87
Cdd:cd15098   9 LIFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFgafmckfvHYFFTVSMLV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  88 liltqsSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGlTPmfgwnnlSEVEQAwIANGSVGEPVI 167
Cdd:cd15098  89 ------SIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMA-SP-------VAVHQD-LVHHWTASNQT 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 168 KCEFEKVISMEYMVY--FNFFVWVLPPLLLMVLIYLEVFylirKQLNKKVSASSgdpQKYYGKELKIAKSLALILFLFAL 245
Cdd:cd15098 154 FCWENWPEKQQKPVYvvCTFVFGYLLPLLLITFCYAKVL----NHLHKKLKNMS---KKSERSKKKTAQTVLVVVVVFGI 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444 246 SWLPLHILNCITLF--CPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15098 227 SWLPHHIIHLWVEFgdFPLTQASFVLRITAHCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
27-291 2.13e-12

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 66.20  E-value: 2.13e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  27 NVLVIWAVKVNQALRDATFCFIVSLAVADVAVG-ALVIPLAILINIGPQTyfhTCLMVACPVLILTQSSILALLAIAVDR 105
Cdd:cd15961  18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGiGLILNFIFAYLLQSEA---AKLVTVGLIVASFSASVCSLLAITVDR 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 106 YLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVeqawiANGSVGEPVIKCEfEKVISMEYMVYFNF 185
Cdd:cd15961  95 YLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPVMGWNCLADE-----STCSVVRPLTKNN-AAILSVSFLLMFAL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 186 FVwvlpplllmvLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFcptcQK 265
Cdd:cd15961 169 ML----------QLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADY----TY 234
                       250       260
                ....*....|....*....|....*.
gi 56699444 266 PSILIYIAIFLTHGNSAMNPIVYAFR 291
Cdd:cd15961 235 PSIYTYATLLPATYNSIINPVIYAFR 260
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
27-288 9.70e-12

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 64.20  E-value: 9.70e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  27 NVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF---HTCLM-VACPVLILTqSSILALLAIA 102
Cdd:cd15328  18 NLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQlgrSLCQVwISFDVLCCT-ASIWNVTAIA 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 103 VDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPM-FGWNNlseveqawiangSVGEPVIKCEFEKVISMEYMV 181
Cdd:cd15328  97 LDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLlFGWGE------------TYSEDSEECQVSQEPSYTVFS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 182 YFNFFvwvlpplLLMVLIYLEVFYLIRKQLNkkvsassgdpqkyygKELKIAKSLALILFLFALSWLPLHILNCITLFCp 261
Cdd:cd15328 165 TFGAF-------YLPLCVVLFVYWKIYKAAQ---------------KEKRAALMVGILIGVFVLCWIPFFLTELISPLC- 221
                       250       260
                ....*....|....*....|....*..
gi 56699444 262 TCQKPSILIYIAIFLTHGNSAMNPIVY 288
Cdd:cd15328 222 SCDIPPIWKSIFLWLGYSNSFFNPLIY 248
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
18-299 1.21e-11

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 63.94  E-value: 1.21e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVG-ALVIPLAILINIGPQTYFHTclMVACPVLILTQ---- 92
Cdd:cd14995   9 LICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLvAAGLPNEIESLLGPDSWIYG--YAGCLLITYLQylgi 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 -SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVgLTPMFGWNNLSEVEQAWIAngsvgepVIKCEF 171
Cdd:cd14995  87 nASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLY-CSPWLFLLDLSIKHYGDDI-------VVRCGY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 172 eKVISMEYMVYF--NFFVWVLPPLLLMVLIY---LEVFYLIRKQlnkkvsassgdpqkyygkelkIAKSLALILFLFALS 246
Cdd:cd14995 159 -KVSRHYYLPIYlaDFVLFYVIPLLLAIVLYgliGRILFSSRKQ---------------------VTKMLAVVVVLFALL 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56699444 247 WLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd14995 217 WMPYRTLVVYNSFASPPYLDLWFLLFCRTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
27-291 1.21e-11

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 64.13  E-value: 1.21e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  27 NVLVIWAVKVNQALRDATFCFIVSLAVADVAVG-ALVIPLAILINIGPQTYFHTCLMVACPVLiltQSSILALLAIAVDR 105
Cdd:cd15963  18 NAIVVAVIFYTPAFRAPMFLLIGSLATADLLAGlGLILHFAFVYCIQSAPVNLVTVGLLAPSF---TASVSSLLAITIDR 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 106 YLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEveqawIANGSVGEPVIKCEFEKVISMEYMVYfnf 185
Cdd:cd15963  95 YLSLYNALTYYSERTVTRTYIMLILTWGASLCLGLLPVVGWNCLKD-----PSTCSVVKPLTKNHLVILSISFFMVF--- 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 186 fvwvlpplLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFcptcQK 265
Cdd:cd15963 167 --------ALMLQLYAQICRIVCRHAHQIALQRHFLPTSHYVTTRKGIATLAVILGTFASCWLPFAVYCLLGDY----TY 234
                       250       260
                ....*....|....*....|....*.
gi 56699444 266 PSILIYIAIFLTHGNSAMNPIVYAFR 291
Cdd:cd15963 235 PALYTYATLLPATYNSMINPIIYAFR 260
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
27-291 1.43e-11

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 63.65  E-value: 1.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  27 NVLVIWAVKVNQALRDATFCFIVSLAVADVAVGalvipLAILINIGPQTYFHTCLMVACPVLILTQS---SILALLAIAV 103
Cdd:cd15100  18 NAIVVAIIFSTPSLRAPMFLLIGSLALADLLAG-----LGLILHFVFRYCVYSEALSLVSVGLLVAAfsaSVCSLLAITV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 104 DRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEveqawIANGSVGEPVIKCEFeKVISMEYMVYF 183
Cdd:cd15100  93 DRYLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLPVLGWNCLRE-----GSSCSVVRPLTKNHL-AVLAVAFLLVF 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 184 NFFVwvlpplllmvLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLhilnciTLFC--P 261
Cdd:cd15100 167 ALML----------QLYAQICRIVLRHAHQIALQRHFLAPSHYVATRKGVSTLALILGTFAACWIPF------AVYCllG 230
                       250       260       270
                ....*....|....*....|....*....|
gi 56699444 262 TCQKPSILIYIAIFLTHGNSAMNPIVYAFR 291
Cdd:cd15100 231 DGSSPALYTYATLLPATYNSMINPIIYAFR 260
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
27-291 1.74e-11

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 63.38  E-value: 1.74e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  27 NVLVIWAVKVNQALRDATFCFIVSLAVADVAVGalvipLAILINIGPQTYFHTCLMVACPVLILT---QSSILALLAIAV 103
Cdd:cd15960  18 NAIVIAILFYTPSLRAPMFILIGSLALADLLAG-----LGLIANFVAIYVMNSEAVTLCSAGLLLaafSASVCSLLAITV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 104 DRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVeqawiANGSVGEPVIKCEfEKVISMEYMVYF 183
Cdd:cd15960  93 DRYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIGLLPAMGWNCLRAP-----ASCSVLRPVTKNN-AAVLAVSFLLLF 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 184 NFFVwvlpplllmvLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITlfcpTC 263
Cdd:cd15960 167 ALMM----------QLYLQICRIAFRHAQQIAVQHQFVNFCLASSTRKGVSTLSLILATFAFCWVPFAVYSMVA----DS 232
                       250       260
                ....*....|....*....|....*...
gi 56699444 264 QKPSILIYIAIFLTHGNSAMNPIVYAFR 291
Cdd:cd15960 233 SYPMIYTYYLVLPAACNSVINPIIYAFR 260
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
17-157 1.81e-11

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 63.42  E-value: 1.81e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSS 94
Cdd:cd15214   7 IIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVvwCNFSALLYLLISSAS 86
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWI 157
Cdd:cd15214  87 MLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLEFDRFKWM 149
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
17-299 1.95e-11

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 63.36  E-value: 1.95e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGalVIPLAILINIGPQTYFHT---CLMVACPVLILTQS 93
Cdd:cd15346   8 IIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAG--VAYTANLLLSGATTYKLTptqWFLREGSMFVALSA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVkIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAwiangsvgepvikcefEK 173
Cdd:cd15346  86 SVFSLLAIAIERYITM-LKMKLHNGSNSFRSFLLISACWVISLILGGLPIMGWNCISALSSC----------------ST 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 VISMEYMVYFNFFVWVLPPLLLMVLI-YLEVFYLIRKQLNKKVSASSGD-PQKYYGKELKIAKSLALILFLFALSWLPLH 251
Cdd:cd15346 149 VLPLYHKHYILFCTTVFTLLLLSIVIlYCRIYSLVRTRSRRLTFRKNIRkASRSSEKSMALLKTVIIVLSVFIACWAPLF 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56699444 252 IL-----NCITLFCPTCQKPSILIYIAIFlthgNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15346 229 ILllldvGCKVKTCSILFKAEYFLVLAVL----NSATNPIIYTLTNKEMRRAF 277
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
27-291 2.11e-11

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 63.41  E-value: 2.11e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  27 NVLVIWAVKVNQALRDATFCFIVSLAVADVAVG-ALVIPLAILINIGPQTYfhTCLMVACPVLILTqSSILALLAIAVDR 105
Cdd:cd15962  18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGcGLILNFVFQYVIQSETI--SLITVGFLVASFT-ASVSSLLAITVDR 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 106 YLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVeqawiANGSVGEPVIKCEfekvISMEYMVYFNF 185
Cdd:cd15962  95 YLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGLLPVLGWNCLEER-----ASCSIVRPLTKSN----VTLLSASFFFI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 186 FVwvlppllLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILnCITlfcPTCQK 265
Cdd:cd15962 166 FI-------LMLHLYIKICKIVCRHAHQIALQQHFLTASHYVATKKGVSTLAIILGTFGASWLPFAIY-CVV---GDHEY 234
                       250       260
                ....*....|....*....|....*.
gi 56699444 266 PSILIYIAIFLTHGNSAMNPIVYAFR 291
Cdd:cd15962 235 PAVYTYATLLPATYNSMINPIIYAYR 260
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
17-145 2.22e-11

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 63.05  E-value: 2.22e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILinigpqTYFHT--------CLMVACPVL 88
Cdd:cd15210   8 IVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAAS------TFLHQawihgetlCRVFPLLRY 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 56699444  89 ILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFG 145
Cdd:cd15210  82 GLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLG 138
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
15-299 2.30e-11

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 63.25  E-value: 2.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAILINIGPQTYFHT--CLMVACPVLILTQ 92
Cdd:cd15093   6 IYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELF-MLGLPFLAASNALRHWPFGSvlCRLVLSVDGINMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPVikcEFE 172
Cdd:cd15093  85 TSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQDGSSACNMQWPEPA---AAW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 KVISMEYMVYFNFFVwvlppllLMVLIYLEVFYLIRKQlnkKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHI 252
Cdd:cd15093 162 SAGFIIYTFVLGFLL-------PLLIICLCYLLIVIKV---KSAGLRAGWQQRKRSERKVTRMVVMVVVVFVICWLPFYV 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56699444 253 LNCITLFCPTCQKPSI--LIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15093 232 LQLVNVFVQLPETPALvgVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
18-299 2.44e-11

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 63.04  E-value: 2.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILInIGPQTYFHTclMVACPV-----LILTQ 92
Cdd:cd15334   9 ILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMY-IVKETWIMG--QVVCDIwlsvdITCCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFgWNNLSEVEQawiangsvGEPVIKceFE 172
Cdd:cd15334  86 CSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLF-WRHQTTSRE--------DECIIK--HD 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 KVISMEYMVYFNFFVwvlpplllMVLIYLEVFYLIRKQLNkkvsassgdpqkyygKELKIAKSLALILFLFALSWLPLHI 252
Cdd:cd15334 155 HIVFTIYSTFGAFYI--------PLALILILYYKIYRAAT---------------RERKAATTLGLILGAFVICWLPFFV 211
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56699444 253 LNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15334 212 KEVIVNTCDSCYISEEMSNFLTWLGYINSLINPLIYTIFNEDFKKAF 258
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
12-299 2.67e-11

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 62.98  E-value: 2.67e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  12 YIGIEVLIAL--VSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGAL----VIPLAILIN----IGPQTYFHTCL 81
Cdd:cd15352   1 FIKAEVFLTLgiVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSnsleTIMIAVLNSgylvISDQFIQHMDN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  82 MVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTpmfgwnnlseveqawiangs 161
Cdd:cd15352  81 VFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIV-------------------- 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 162 vgePVIKCEFEKVISMEYMVYFNFFVwvlppllLMVLIYLEVFYLIRKQLnKKVSA--SSGDPQKYYGKELKIAKSLALI 239
Cdd:cd15352 141 ---FIVYSESKTVIVCLITMFFAMLV-------LMATLYVHMFLFARLHV-KRIAAlpPAVDGAPQQRSCMKGAVTITIL 209
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56699444 240 LFLFALSWLPLHILNCITLFCPTcqKPSILIYIAIFLTH-----GNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15352 210 LGVFIVCWAPFFLHLILIISCPH--NPYCLCYTSHFNTYlvlimCNSVIDPLIYAFRSLEMRKTF 272
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
18-296 3.92e-11

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 62.46  E-value: 3.92e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSSI 95
Cdd:cd15012   8 LVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEvlCRMYQFVHSLSYTASI 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGlTPMFGWNNLSEVeqawIANGSVGEPVIKCEFEKVI 175
Cdd:cd15012  88 GILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYN-TPYFVFSQTVEI----LVTQDGQEEEICVLDREMF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 176 SMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKqlnkkvsASSGDPQKyygkelKIAKSLALILFLFALSWLPLHILNC 255
Cdd:cd15012 163 NSKLYDTINFIVWYLIPLLIMTVLYSKISIVLWK-------SSSIEARR------KVVRLLVAVVVSFALCNLPYHARKM 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 56699444 256 ITLF-----CPTCQKpSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15012 230 WQYWsepyrCDSNWN-ALLTPLTFLVLYFNSAVNPLLYAFLSKRFR 274
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
18-299 5.73e-11

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 62.31  E-value: 5.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSSI 95
Cdd:cd14970   9 VVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELF-LLGLPFLATSYLLGYWPFGEvmCKIVLSVDAYNMFTSI 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQA------WIANGSVGEPVIKC 169
Cdd:cd14970  88 FCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGGTiscnlqWPDPPDYWGRVFTI 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 efekvismeYMVYFNFFVwvlpplllmVLIYLEVFY-LIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWL 248
Cdd:cd14970 168 ---------YTFVLGFAV---------PLLVITVCYsLIIRRLRSSRNLSTSGAREKRRARRKVTRLVLVVVAVFVVCWL 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444 249 PLHILNCITLFcpTCQKPSILI----YIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd14970 230 PFHVFQIVRLL--IDPPETLTVvgvfLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
23-297 7.62e-11

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 61.76  E-value: 7.62e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  23 SVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILinigpQTYFHTCLMVA--CPVLILTQ-----SSI 95
Cdd:cd15391  14 SVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFT-----QIMLGHWVFPApmCPIVLYVQlvsvtASV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKtvVTQRRAAVAIAGCWILSLVVGLTPMFGWNNlseVEQAWIANGSVgepviKCEFEKVI 175
Cdd:cd15391  89 LTNTAIGIDRFFAVIFPLRSR--HTKSRTKCIIASIWAISFSLSSVQLFAGRT---QRYGQYSEGRV-----LCGESWPG 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 176 SMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKV--SASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHIL 253
Cdd:cd15391 159 PDTSRSAYTVFVMLLTYIIPLLILTSTYGYVGFRLWNRTApgNADKGRDDMQIKSKRKVIKMLVFVVLMFGICWLPLHLF 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56699444 254 NCI----TLFCPTCQKPSILIYIA-IFLTHGNSAMNPIVYAFRIHKFRV 297
Cdd:cd15391 239 NLVqdfsTVFRNMPQHTTRLIYGAcHWIAMSNSFVNPIIYLFMNDSFRS 287
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
10-299 1.04e-10

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 61.44  E-value: 1.04e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPV 87
Cdd:cd15980   1 AVFIASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGStvCKMSGMVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  88 LILTQSSILALLAIAVDRYLRVKIPLRYKtvVTQRRAAVAIAGCWILSLVVgLTPMFGWNNLSEVE--QAWIANGSVGEP 165
Cdd:cd15980  81 GISVSASVFTLVAIAVDRFRCIVYPFKQK--LTISTAVVIIVIIWVLAIAI-MCPSAVMLHVQEEKnyRVVLGSQNKTSP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 166 VIKC-------EFEKVISMeyMVYFNFFVwvlPPLLLMVLIYLEV-FYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLA 237
Cdd:cd15980 158 VYWCredwpnqEMRKIYTT--VLFANIYL---APLSLIVIMYARIgITLFKTAMPHTGKHNQEQRHVVSRKKQKVIKMLL 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56699444 238 LILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIF-----LTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15980 233 IVALLFILSWLPLWTLMMLSDYANLSPNQLQIINIYIYpfahwLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
14-299 1.52e-10

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 60.95  E-value: 1.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  14 GIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGAlviplAILINI---GPQTYFHT---CLMVACPV 87
Cdd:cd15102   5 VVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGA-----AYLANIllsGARTLRLSpaqWFLREGSM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  88 LILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVaIAGCWILSLVVGLTPMFGWNNLSEVEQAwiangsvgepvi 167
Cdd:cd15102  80 FVALSASVFSLLAIAIERHLTMAKMKPYGASKTSRVLLL-IGACWLISLLLGGLPILGWNCLGALDAC------------ 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 168 kcefEKVISMEYMVYFNFFVWVLPPLLLMVLI-YLEVFYLIRKQlNKKVSASSGDPQKyygkeLKIAKSLALILFLFALS 246
Cdd:cd15102 147 ----STVLPLYSKHYVLFCVTIFAGILAAIVAlYARIYCLVRAS-GRKATRASASPRS-----LALLKTVLIVLLVFIAC 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444 247 WLPLHILNCITLFCPTCQKPsILIYIAIFLTHG--NSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15102 217 WGPLFILLLLDVACPVKTCP-ILYKADWFLALAvlNSALNPIIYTLRSRELRRAV 270
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
10-299 1.60e-10

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 60.77  E-value: 1.60e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTC----LMV 83
Cdd:cd15390   1 VLWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFglFYCkfsnFVA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  84 ACPVLIltqsSILALLAIAVDRYLRVKIPLRYKTvvTQRRAAVAIAGCWILSLVVGLTPMFgwnnLSEVEQAWIANGSVG 163
Cdd:cd15390  81 ITTVAA----SVFTLMAISIDRYIAIVHPLRPRL--SRRTTKIAIAVIWLASFLLALPQLL----YSTTETYYYYTGSER 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 164 EPVIKCEFEKVISMEYMVYFNFFVwvlPPLLLMVLIYLEVFY-LIRKQLNKkvSASSGDPQKYYGKEL----KIAKSLAL 238
Cdd:cd15390 151 TVCFIAWPDGPNSLQDFVYNIVLF---VVTYFLPLIIMAVAYtRVGVELWG--SKTIGENTPRQLESVrakrKVVKMMIV 225
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56699444 239 ILFLFALSWLPLHILNCITLFCP--TCQKPSILIYIAIF-LTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15390 226 VVVIFAICWLPYHLYFILTYLYPdiNSWKYIQQIYLAIYwLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
18-145 1.72e-10

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 60.93  E-value: 1.72e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFH---TCLMVACPVLILTQSS 94
Cdd:cd15005   9 LILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIYgalSCKVIAFLAVLFCFHS 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFG 145
Cdd:cd15005  89 AFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFD 139
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
14-296 1.92e-10

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 60.69  E-value: 1.92e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  14 GIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPL---AILINIGPQTYFHtCLMVACPVLIL 90
Cdd:cd15401   5 GVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLillAIFHNGWTLGNIH-CQISGFLMGLS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  91 TQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSlVVGLTPMFgwnnlseveqaWIANGSVGEPVIKCE 170
Cdd:cd15401  84 VIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLT-LAAIVPNF-----------FVGSLQYDPRIYSCT 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 171 FEKVISMEYMVYFnFFVWVLPPLLLMVLIYLEVFYLIrKQLNKKVSASSgdPQKYYGKELKIAKSLALILFLFALSWLPL 250
Cdd:cd15401 152 FAQTVSSSYTITV-VVVHFIVPLSIVTFCYLRIWVLV-IQVKHRVRQDS--KQKLKANDIRNFLTMFVVFVLFAVCWGPL 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56699444 251 HILNCITLFCPTCQKPSI---LIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15401 228 NFIGLAVAINPLKVAPKIpewLFVLSYFMAYFNSCLNAVIYGVLNQNFR 276
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
18-138 1.99e-10

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 60.60  E-value: 1.99e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSSI 95
Cdd:cd15979   9 VIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEviCKAVAYLMGVSVSVST 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVV 138
Cdd:cd15979  89 FSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLI 131
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
18-144 3.28e-10

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 59.81  E-value: 3.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIgpqTYFHTCLMVACPVLILTQ----- 92
Cdd:cd15333  13 LITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTV---TGTWTLGQVVCDIWLSSDitcct 89
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMF 144
Cdd:cd15333  90 ASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFF 141
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
15-299 3.42e-10

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 59.95  E-value: 3.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWaVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQ---TYFHTCLMVACPVLILT 91
Cdd:cd14978   6 VLPVICIFGIIGNILNLV-VLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYsssFLSYFYAYFLPYIYPLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  92 Q----SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNnlseveqawiangsvgepVI 167
Cdd:cd14978  85 NtfqtASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYE------------------VV 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 168 KCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLI------------------RKQLNKKVSASSGDPQKYYGKE 229
Cdd:cd14978 147 ECENCNNNSYYYVIPTLLRQNETYLLKYYFWLYAIFVVLLpfilllilnilliralrkSKKRRRLLRRRRRLLSRSQRRE 226
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56699444 230 LKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSI---LIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd14978 227 RRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLSPIyqlLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
15-296 3.62e-10

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 59.79  E-value: 3.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPG---NVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINigPQTYFHT----CLMVACPV 87
Cdd:cd15075   3 LSIIMAVFSIASvvlNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTN--AVGYFNLgrvgCVLEGFAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  88 LILTQSSILALLAIAVDRYLRVKIPLRYKTVvTQRRAAVAIAGCWILSLVVGLTPMFGWNN--LSEVEQAWIANGSVGEP 165
Cdd:cd15075  81 AFFGIAALCTVAVIAVDRLFVVCKPLGTLTF-QTRHALAGIASSWLWSLIWNTPPLFGWGSyqLEGVMTSCAPDWYSRDP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 166 VikcefekviSMEYMVYFnFFVWVLPPLLLMVLIYLEVFYLIRkQLNKKVSASSGDPQKYygkELKIAKSLALILFLFAL 245
Cdd:cd15075 160 V---------NVSYILCY-FSFCFAIPFAIILVSYGYLLWTLR-QVAKLGVAEGGSTAKA---EVQVARMVVVMVMAFLL 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444 246 SWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15075 226 CWLPYAAFALTVVSKPDVYINPLIATVPMYLAKSSTVYNPIIYIFMNKQFR 276
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
17-147 6.36e-10

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 59.08  E-value: 6.36e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALR-DATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILT-QSS 94
Cdd:cd15341   8 TLCGLLCILENVAVLYLILSSPKLRrKPSYLFIGSLALADFLASVVFACSFVDFHVFHGVDSSAIFLLKLGGVTMSfTAS 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWN 147
Cdd:cd15341  88 LGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYLPLMGWN 140
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
18-296 8.28e-10

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 58.61  E-value: 8.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVaVGALVIPL-AILINIGPQTYF--HTCLMVACPVLILTQSS 94
Cdd:cd15193   9 IIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADL-VFVLTLPFwAASTALGGQWLFgeGLCKLSSFIIAVNRCSS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFgWNNLSEVEQAWIANGSvgepvikcEFEKV 174
Cdd:cd15193  88 ILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLV-YRNLINESVCVEDSSS--------RFFQG 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 175 ISMEyMVYFNFFVwvlpplllMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYgKELKIaksLALILFLFALSWLPLHILN 254
Cdd:cd15193 159 ISLA-TLFLTFVL--------PLIVILFCYCSILVRLRRHFHGAKRTGRRRR-NSLRI---VFAIVTAFVLSWLPFNTLK 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444 255 CITLF---------CPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15193 226 AVRLLlelgggvlpCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFR 276
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
10-299 8.60e-10

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 58.68  E-value: 8.60e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFH--TCLMVACPV 87
Cdd:cd15981   1 AMFILAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDnaMCKMSGLVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  88 LILTQSSILALLAIAVDRYLRVKIPLRYKtvVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPVI 167
Cdd:cd15981  81 GMSVSASVFTLVAIAVERFRCIVHPFRQK--LTLRKAIVTIVIIWVLALIIMCPSAVTLTVTREEHHFMVDDYNNSYPLY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 168 KCeFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYG-----KELKIAKSLALILFL 242
Cdd:cd15981 159 SC-WEAWPDTEMRKIYTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSAPIRGSQGEEEEGrrvskRKIKVINMLIIVALF 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56699444 243 FALSWLPLHILNCITLFCPTCQKPSILIYIAIF-----LTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15981 238 FTLSWLPLWTLMLLTDYGHLSEDQLNLVTVYVFpfahwLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
18-121 9.20e-10

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 58.45  E-value: 9.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCL--MVACPVLILTQS 93
Cdd:cd15917   9 AMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPkmLGIFWFNAREISFDACLaqMFFIHSFTAMES 88
                        90       100
                ....*....|....*....|....*...
gi 56699444  94 SIlaLLAIAVDRYLRVKIPLRYKTVVTQ 121
Cdd:cd15917  89 GV--LLAMAFDRYVAICYPLRYTTILTN 114
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
17-146 1.15e-09

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 58.23  E-value: 1.15e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDatFCFIVSLAVADVAVGALVIPLAILIniGPQTYFHTCLMVA-CPVLI-----L 90
Cdd:cd15220   7 VLLDLTALVGNTAVMVVIAKTPHLRK--FAFVCHLCVVDLLAALLLMPLGILS--SSPFFLGVVFGEAeCRVYIflsvcL 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444  91 TQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGW 146
Cdd:cd15220  83 VSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGW 138
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
17-296 1.32e-09

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 58.25  E-value: 1.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPL---AILINIGPQTYFHtCLMVACPVLILTQS 93
Cdd:cd15209   8 IVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLilhAIFHNGWTLGQLH-CQASGFIMGLSVIG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFgwnnlseveqawIANGSVGEPVIKCEFEK 173
Cdd:cd15209  87 SIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFF------------IGSLQYDPRIYSCTFAQ 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 VISMEY---MVYFNFFVwvlpPLLLMVLIYLEVFYLIrkqLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPL 250
Cdd:cd15209 155 TVSTVYtitVVVIHFLL----PLLIVSFCYLRIWVLV---LQVRQRVKPDQRPKLKPADVRNFLTMFVVFVLFAVCWAPL 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56699444 251 HILNCITLFCPTCQKPSI---LIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15209 228 NFIGLAVAINPKEMAPKIpewLFVASYFMAYFNSCLNAIIYGLLNQNFR 276
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
18-296 1.41e-09

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 58.02  E-value: 1.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVI-WAVKVNQALRDATFCFIVSLAVADVAVGalvIPLAIlINIGPQTYFH-------------TCLMV 83
Cdd:cd14980   9 IIGILALIGNILVIiWHISSKKKKKKVPKLLIINLAIADFLMG---IYLLI-IAIADQYYRGryaqyseewlrspPCLLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  84 ACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVvTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANgSVG 163
Cdd:cd14980  85 CFLVSLSSLMSVLMMLLITLDRYICIVYPFSNKRL-SYKSAKIILILGWLFSIIFAAIPILYSINQPGDNRLYGYS-SIC 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 164 EPVIKCEFEKVISMEYMVYFNFFVWVLPPLllmvlIYLEVFYLIRK-QLNKKVSASSgdpqkyygKELKIAKSLALILFL 242
Cdd:cd14980 163 MPSNVSNPYYRGWLIAYLLLTFIAWIIICI-----LYILIFISVRKsRKSARRSSSK--------RDKRIAIRLALILIT 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 56699444 243 FALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd14980 230 DLICWLPYYIVIFSGLLTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTFK 283
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
15-299 1.42e-09

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 58.00  E-value: 1.42e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAILINIGPQTYFHT--CLMVACPVLILTQ 92
Cdd:cd15970   6 IYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELL-MLSVPFLVTSTLLRHWPFGSllCRLVLSVDAINMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPvikcefe 172
Cdd:cd15970  85 TSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDGSVACNMQMPEP------- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 kviSMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQlnkKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHI 252
Cdd:cd15970 158 ---SQRWLAVFVVYTFLMGFLLPVIAICLCYILIIVKM---RVVALKAGWQQRKRSERKITLMVMMVVTVFVICWMPFYV 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56699444 253 LNCITLFCPtcQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15970 232 VQLVSVFVG--QHDATVSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
10-296 1.52e-09

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 57.99  E-value: 1.52e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAI--LINIGPQTYFHTCLMVACPV 87
Cdd:cd15402   1 TALACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLtsIFHNGWNLGYLHCQISGFLM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  88 LILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFgwnnlseveqawIANGSVGEPVI 167
Cdd:cd15402  81 GLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLF------------VGSLQYDPRIY 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 168 KCEFEKVISMEY---MVYFNFFVwvlpPLLLMVLIYLEVFYLIrKQLNKKVSASsgDPQKYYGKELKIAKSLALILFLFA 244
Cdd:cd15402 149 SCTFAQSVSSAYtiaVVFFHFIL----PIIIVTFCYLRIWILV-IQVRRRVKPD--NKPKLKPHDFRNFVTMFVVFVLFA 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444 245 LSWLPLHILNCITLFCPTCQKPSI---LIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15402 222 VCWAPLNFIGLAVAVDPETIVPRIpewLFVASYYMAYFNSCLNAIIYGLLNQNFR 276
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
15-299 1.60e-09

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 57.89  E-value: 1.60e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADvAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQ 92
Cdd:cd15972   6 VYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALAD-ELFMLGLPFLAAQNALSYWPFGSfmCRLVMTVDAINQF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWN---NLSEVEQAWIANGSVGEPVIkc 169
Cdd:cd15972  85 TSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGvpgGMGTCHIAWPEPAQVWRAGF-- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 efekvisMEYMVYFNFFVWVLPPLLLMVLIYLEVfylirKQLNKKVSASsgdPQKYYGKELKIAKSLALILFLFALSWLP 249
Cdd:cd15972 163 -------IIYTATLGFFCPLLVICLCYLLIVVKV-----RSSGRRVRAT---STKRRGSERKVTRMVVIVVAAFVLCWLP 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56699444 250 LHILNCITLFCPTCQKPSI--LIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15972 228 FYALNIVNLVCPLPEEPSLfgLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
15-147 1.97e-09

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 57.54  E-value: 1.97e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALR-DATFCFIVSLAVADVaVGALVIPLAILInigpqtyFHTC---------LMVA 84
Cdd:cd15099   6 LCFLAGPVTFLENILVLLTILSSTALRrRPSYLFIGSLALADM-LASVIFTISFLD-------FHVFhqrdsrnlfLFKL 77
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56699444  85 CPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWN 147
Cdd:cd15099  78 GGVTMAFTASVGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLMGWR 140
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
17-299 2.17e-09

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 57.13  E-value: 2.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILIniGPQTYFHTCL---MVACPVLILTQS 93
Cdd:cd15347   8 VILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVAFIANILLS--GSVTFRLTPVqwfIREGTAFITLSA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYL---RVKIPLRYKTVvtqrRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAwiangsvgepvikce 170
Cdd:cd15347  86 SVFSLLAIAIERHVaitKVKLYGSDKNC----RMVLLIGACWVISIVLGGLPILGWNCIGNLEDC--------------- 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 171 fEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASsgdpqkyygKELKIAKSLALILFLFALSWLPL 250
Cdd:cd15347 147 -STVLPLYSKHYILFVVTIFSIILLSIVILYVRIYCIVRSSHAEMAAP---------QTLALLKTVTIVLGVFIVCWLPA 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444 251 HILNCITLFCPTCQKPsILIYIAIFLTHG--NSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15347 217 FIILLLDTSCKVKSCP-ILYKADYFFSVAtlNSALNPVIYTLRSKDMRKEF 266
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
13-148 2.18e-09

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 57.46  E-value: 2.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  13 IGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGaLVIPLAILINIGPQTYFHTCLMVACPVLILTQ 92
Cdd:cd15905   2 FWLSVPLSSLIIFANLFIILGIACNRKLHNTANYFFLSLLLADLLTG-VALPFIPGMSNESRRGYHSCLFVYVAPNFLFL 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNN 148
Cdd:cd15905  81 SFLANLLMVHYERYLCIVYPLQYHNFWVHRWVPLALLLTWALPLLFACLPALGWNN 136
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
18-140 2.90e-09

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 57.06  E-value: 2.90e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTclMVACPVLILTQS---- 93
Cdd:cd15394   9 LVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRGWVFG--RFMCYFVFLMQPvtvy 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 56699444  94 -SILALLAIAVDRYLRVKIPLRYKtvVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15394  87 vSVFTLTAIAVDRYYVTVYPLRRR--ISRRTCAYIVAAIWLLSCGLAL 132
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
18-137 3.84e-09

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 56.74  E-value: 3.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCL--MVACPVLILTQS 93
Cdd:cd15222   9 LLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPtvLGIFWFNAREISFDACLaqMFFIHTFSFMES 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 56699444  94 SILalLAIAVDRYLRVKIPLRYKTVVTQRRAA---VAIAGCWILSLV 137
Cdd:cd15222  89 SVL--LAMAFDRFVAICNPLRYASILTNSRIAkigLAIVLRSVLLLL 133
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
18-140 5.77e-09

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 56.14  E-value: 5.77e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCL--MVACPVLILTQS 93
Cdd:cd15221   9 SMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPkmLAIFWFGAGEISFDGCLtqMFFVHFVFVTES 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 56699444  94 SILalLAIAVDRYLRVKIPLRYKTVVTQRR------AAVAIAGCWILSLVVGL 140
Cdd:cd15221  89 AIL--LAMAFDRYVAICYPLRYTTILTHSVigkigvAAVARSFCIVFPFVFLL 139
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
15-299 7.52e-09

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 55.80  E-value: 7.52e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHT-CLMVACPVLILT 91
Cdd:cd15134   6 IYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPfeLYTIWQQYPWVFGEVfCKLRAFLSEMSS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  92 QSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEVEQAWIANGSVGEPVIkCEF 171
Cdd:cd15134  86 YASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCAL-PFAIQTRIVYLEYPPTSGEALEESAF-CAM 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 172 EKVISMEYMVY-FNFFVWVLPPLLLMVLIYLEV-FYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLP 249
Cdd:cd15134 164 LNEIPPITPVFqLSTFLFFIIPMIAIIVLYVLIgLQLRRSTLLRRGQRSVSGGRRSSQSRRTVLRMLVAVVVAFFICWAP 243
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444 250 LHILNCITLFCPTCQKP-----SILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15134 244 FHAQRLLTVYAKNMTPPylfinRILFYISGVLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
17-148 1.09e-08

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 55.32  E-value: 1.09e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILInIGPQTY---FHTCLMVACPVLILTQS 93
Cdd:cd15335   8 ALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITY-IVMDTWtlgYFICEIWLSVDMTCCTC 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFgWNN 148
Cdd:cd15335  87 SILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLF-WRN 140
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
18-150 1.69e-08

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 54.70  E-value: 1.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSI-- 95
Cdd:cd15206   9 VIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVSVst 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVgLTPMFGWNNLS 150
Cdd:cd15206  89 FTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLI-MSPILVFSNLI 142
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
17-135 1.91e-08

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 54.54  E-value: 1.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGP---------QTYFHTCLMVac 85
Cdd:cd15235   9 LAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPkmLANLLSGSKtisyagclaQMYFFIAFGN-- 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444  86 pvlilTQSSILAllAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILS 135
Cdd:cd15235  87 -----TDSFLLA--VMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLS 129
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
11-145 2.44e-08

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 54.17  E-value: 2.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  11 AYIGIEVLIALVSVPGNVLVIWA-VKVNQALRDATF-CFIVSLAVADVAVGALVIPLAILINI------GPQ---TYFHT 79
Cdd:cd14981   2 ESPAPPALMFVFGVLGNLLALIVlARSSKSHKWSVFyRLVAGLAITDLLGILLTSPVVLAVYAsnfewdGGQplcDYFGF 81
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444  80 CLMVAcpvlILtqSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFG 145
Cdd:cd14981  82 MMSFF----GL--SSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLLG 141
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
15-299 2.46e-08

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 54.42  E-value: 2.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADV--AVGALVIPLAILINIGPQTYFhTCLMVACPVLILTQ 92
Cdd:cd15974   6 IYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADElfMLGLPFLATQNAISYWPFGSF-LCRLVMTVDGVNQF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEVEQAwiANGSVGEPVikcefe 172
Cdd:cd15974  85 TSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVL-PVIIFSDVQPDLNT--CNISWPEPV------ 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 KVISMEYMVY---FNFFVWVLPPLLLMVLIYLEVfylirkqlnkKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLP 249
Cdd:cd15974 156 SVWSTAFIIYtavLGFFGPLLVICLCYLLIVIKV----------KSSGLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLP 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56699444 250 LHILNCITLFCPTCQKPSI--LIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15974 226 FYMLNIVNLIVILPEEPAFvgVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
18-143 2.52e-08

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 54.31  E-value: 2.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCL--MVACPVLILTQS 93
Cdd:cd15952   9 AVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPkmLGIFWFNLREISFGGCLaqMFFIHTFTGMES 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILalLAIAVDRYLRVKIPLRYKTVVTQRRAAVaIAGCWILSLVVGLTPM 143
Cdd:cd15952  89 AVL--VAMAFDRYVAICNPLRYTTILTNKVISV-IALGIVLRPLLLVLPF 135
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
17-297 2.90e-08

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 54.12  E-value: 2.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAI--LINIGPQTYFHT-CLMVACPVLILTQS 93
Cdd:cd15131   8 VLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLI-FLCMPLDLyrLWQYRPWNFGDLlCKLFQFVSESCTYS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGlTPMFgwnNLSEVEQawiANGSVGEPVIKCEfek 173
Cdd:cd15131  87 TILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSA-GPIF---VLVGVEH---ENGTNPIDTNECK--- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 viSMEYMV---YFNFFVWVLPPLLLMVLIYLEVFY-LIRKQLNKKVSASSGDPQKYYGKELK-IAKSLALILFLFALSWL 248
Cdd:cd15131 157 --ATEYAVrsgLLTIMVWVSSVFFFLPVFCLTVLYsLIGRKLWRRRRENIGPNASHRDKNNRqTVKMLAVVVFAFVLCWL 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 56699444 249 PLHILNciTLFCPTCQKPSILI--------YIAIFLTHGNSAMNPIVYAFRIHKFRV 297
Cdd:cd15131 235 PFHVGR--YLFSKSFEAGSLEIalisqycnLVSFVLFYLSAAINPILYNIMSKKYRV 289
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
13-146 2.99e-08

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 53.69  E-value: 2.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  13 IGIEVLIALV--SVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIgPQTY---FHTCLMVACPV 87
Cdd:cd15215   1 IRSVLIVIFLcaSLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSV-PLFWpldSHLCTALVVLM 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56699444  88 LILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGW 146
Cdd:cd15215  80 HLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGW 138
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
18-299 3.24e-08

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 54.10  E-value: 3.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTY-------FHTCLMVACpvlil 90
Cdd:cd16002   9 VIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYygleyckFHNFFPIAA----- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  91 TQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRaaVAIAGCWILSLVVGLtPMFGWNNLSEVEQAWIANGSVGEPVIKcE 170
Cdd:cd16002  84 VFASIYSMTAIALDRYMAIIHPLQPRLSATATK--VVICVIWVLAFLLAF-PQGYYSDTEEMPGRVVCYVEWPEHEER-K 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 171 FEKV--ISMEYMVYFnffvwvlppLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWL 248
Cdd:cd16002 160 YETVyhVCVTVLIYF---------LPLLVIGCAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWL 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 56699444 249 PLHILNCITLFCPTC--QKPSILIYIAIFLTHGNSAM-NPIVYAFRIHKFRVTF 299
Cdd:cd16002 231 PYHIYFLLQYFHPELyeQKFIQQVYLAIMWLAMSSTMyNPIIYCCLNDRFRVGF 284
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
10-137 3.32e-08

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 54.03  E-value: 3.32e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAIL-------INIGP----QTYF- 77
Cdd:cd15928   1 AAVTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLI-FLVLPLDLYrlwryrpWRFGDllcrLMYFf 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56699444  78 -HTClmvacpvlilTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLV 137
Cdd:cd15928  80 sETC----------TYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIV 130
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
18-153 3.37e-08

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 53.88  E-value: 3.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQS--SI 95
Cdd:cd15389   9 IIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVyvST 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKtvVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEVE 153
Cdd:cd15389  89 LTLTAIALDRHRVILHPLKPR--ITPCQGVVVIAIIWIMASCLSL-PHAIYQKLVEFE 143
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
17-140 3.42e-08

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 53.82  E-value: 3.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAI---LINIGPQTYFHTclmvACPVLILTQS 93
Cdd:cd15204   8 VLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMdyyVVRQRSWTHGDV----LCAVVNYLRT 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 56699444  94 SIL-----ALLAIAVDRYLRVKIPLRYKtvVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15204  84 VSLyvstnALLVIAIDRYLVIVHPLKPR--MKRRTACVVIALVWVVSLLLAI 133
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
18-299 3.65e-08

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 53.68  E-value: 3.65e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAV-KVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLI-LTQ-SS 94
Cdd:cd15097   9 LIFLLGTVGNSLVLAVLlRSGQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIyLTMyAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVvgltpmFGWNNLSEVEQAWIANGSVGEPVIKCEFEKV 174
Cdd:cd15097  89 SFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLL------FAGPYLSYYDLIDYANSTVCMPGWEEARRKA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 175 ISMEymvyfNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYygkelKIAKSLALILFLFALSWLPLHILN 254
Cdd:cd15097 163 MDTC-----TFAFGYLIPVLVVSLSYTRTIKYLWTAVDPLEAMSESKRAKR-----KVTKMIIIVTALFCLCWLPHHVVI 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56699444 255 CITLF--CPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15097 233 LCYLYgdFPFNQATYAFRLLSHCMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
15-147 4.70e-08

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 53.37  E-value: 4.70e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALR-DATFCFIVSLAVADVaVGALVIPLAILinigpqtYFHTCLMVACPVLILTQ- 92
Cdd:cd15340   6 LSLTLGTFTVLENLLVLCVILHSRSLRcRPSYHFIGSLAVADL-LGSVIFVYSFL-------DFHVFHRKDSPNVFLFKl 77
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56699444  93 --------SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWN 147
Cdd:cd15340  78 ggvtasftASVGSLFLTAIDRYISIHRPLAYKRIVTRTKAVIAFCVMWTIAIVIAVLPLLGWN 140
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
14-138 6.48e-08

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 52.85  E-value: 6.48e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  14 GIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGAlVIPLAILINI-GPQTYFHTCLMVACPVLILTQ 92
Cdd:cd15368   5 VVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLAC-FLPFQIVYHIqRNHWIFGKPLCNVVTVLFYAN 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 56699444  93 --SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVV 138
Cdd:cd15368  84 mySSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTA 131
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
27-299 8.92e-08

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 52.51  E-value: 8.92e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  27 NVLVIWAVKVNQALRDATFCFIVSLAVADVAVGalvipLAILINI---GPQTYFHT---CLMVACPVLILTQSSILALLA 100
Cdd:cd15345  18 NLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAG-----IAYKVNIlmsGKKTFSLSptqWFLREGSMFVALGASTFSLLA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 101 IAVDRYLRVkIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAwiangsvgepvikcefEKVISMEYM 180
Cdd:cd15345  93 IAIERHLTM-IKMRPYDANKRYRVFLLIGTCWLISVLLGALPILGWNCLDNLPDC----------------STILPLYSK 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 181 VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPqkyygKELKIAKSLALILFLFALSWLPLHIL-----NC 255
Cdd:cd15345 156 KYVAFCISIFIAILVAIVILYARIYILVKSSSRRVTNHRNSE-----RSMALLRTVVIVVGVFIACWSPLFILllidvAC 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56699444 256 ITLFCPTCQKPSILIYIAIFlthgNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15345 231 EVKQCPILYKADWFIALAVL----NSAMNPIIYTLASKEMRRAF 270
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
18-138 9.47e-08

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 52.57  E-value: 9.47e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSI-- 95
Cdd:cd15978   9 LIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSVst 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVV 138
Cdd:cd15978  89 FNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTI 131
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
21-126 9.76e-08

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 52.42  E-value: 9.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  21 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSSILAL 98
Cdd:cd15950  12 VIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPkmLSIFWLGSAEISFEACFTQMFFVHSFTAVESGVL 91
                        90       100
                ....*....|....*....|....*...
gi 56699444  99 LAIAVDRYLRVKIPLRYKTVVTQRRAAV 126
Cdd:cd15950  92 LAMAFDRYVAICHPLRYSAILTSQVIAQ 119
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
15-140 1.20e-07

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 52.28  E-value: 1.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAIlINIGPQTYFHTclmVACPVLILTQ-- 92
Cdd:cd15178   6 IYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLF-ALTLPFWA-VSVVKGWIFGT---FMCKLVSLLQea 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 56699444  93 ---SSILALLAIAVDRYLRVKIPLRyktVVTQRRAAV--AIAGCWILSLVVGL 140
Cdd:cd15178  81 nfySGILLLACISVDRYLAIVHATR---ALTQKRHLVkfVCAGVWLLSLLLSL 130
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
17-299 1.40e-07

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 52.10  E-value: 1.40e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVL--ILTQSS 94
Cdd:cd15296   8 ALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVdyLLCTAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAV-AIAGCWILSLVVGLTPMFGWNnlseveqaWIANGSVgEPVIKCEFEk 173
Cdd:cd15296  88 VFNIVLISYDRFLSVTRAVSYRAQKGMTRQAVlKMVLVWVLAFLLYGPAIISWE--------YIAGGSI-IPEGECYAE- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 vismeymVYFNFFVWVLPPLLLMVLIYLEVFYlirkqLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHIL 253
Cdd:cd15296 158 -------FFYNWYFLMTASTLEFFTPFISVTY-----FNLSIYLNIQKRRFRLSRDKKVAKSLAIIVCVFGLCWAPYTLL 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 56699444 254 NCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15296 226 MIIRAACHGHCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
10-296 1.61e-07

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 51.78  E-value: 1.61e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPL---AILINIGPQTYFHtCLMVACP 86
Cdd:cd15400   1 TALSSVLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLvlvAIFHNGWALGEMH-CKVSGFV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  87 VLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSlVVGLTPMFgwnnlseveqaWIANGSVGEPV 166
Cdd:cd15400  80 MGLSVIGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALT-VVAIVPNF-----------FVGSLEYDPRI 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 167 IKCEFEKVISMEY---MVYFNFFVwvlpPLLLMVLIYLEVFYLIrKQLNKKVSASSGDPQKyyGKELKIAKSLALILFLF 243
Cdd:cd15400 148 YSCTFVQTASSSYtiaVVVIHFIV----PITVVSFCYLRIWVLV-IQVRRKVKSESKPRLK--PSDFRNFLTMFVVFVIF 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444 244 ALSWLPLHILNCITLFCPTCQKPSI---LIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15400 221 AICWAPLNLIGLAVAINPQEMAPKVpewLFVVSYFMAYFNSCLNAIIYGLLNQNFR 276
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
17-299 1.89e-07

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 51.79  E-value: 1.89e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIL-------INIGP-QTYFHTCLMVAcpvl 88
Cdd:cd15357   8 AVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYemwsnypFLFGPvGCYFKTALFET---- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  89 iLTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL--TPMFGwnnlseVEQAWIANGSVGEPV 166
Cdd:cd15357  84 -VCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIpnTSIHG------IKLQYFPNGTLIPDS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 167 IKCEFEKVISM-EYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKElkIAKSLALILFLFAL 245
Cdd:cd15357 157 ATCTVVKPLWIyNLIIQITSLLFYVLPMGVISVLYYLMGLKLRGDKSLEADEMNVNIQRPSRKS--VTKMLFVLVLVFAI 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56699444 246 SWLPLHILNCITLFCPTCQKPSILIYIAIFLTHG-----NSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15357 235 CWAPFHVDRLFFSFVVEWTEPLANVFNLIHVVSGvffylSSAVNPIIYNLLSRRFRTAF 293
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
17-297 2.42e-07

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 51.42  E-value: 2.42e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAIlINIgpqtYFHTCLM--VACPVLILTQS- 93
Cdd:cd15079   8 IFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLM-MIKMPIFI-YNS----FYEGWALgpLGCQIYAFLGSl 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 ----SILALLAIAVDRYLRVKIPLRyKTVVTQRRAAVAIAGCWILSLVVGLTP-MFGWNNlseveqaWIANGSVGepviK 168
Cdd:cd15079  82 sgigSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWALLPlLFGWGR-------YVPEGFLT----S 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 169 CEF----EKVISMEYMVYFNFFVWvlppLLLMVLIYLEVFYLIR-------------KQLNKKVSASSGDPQKyYGKELK 231
Cdd:cd15079 150 CSFdyltRDWNTRSFVATIFVFAY----VIPLIIIIYCYSFIVKavfahekalreqaKKMNVVSLRSNADANK-QSAEIR 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444 232 IAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRV 297
Cdd:cd15079 225 IAKVALTNVFLWFIAWTPYAVVALIGAFGNQSLLTPLVSMIPALFAKTAACYNPIVYAISHPKYRL 290
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
18-299 2.80e-07

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 51.15  E-value: 2.80e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVnQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQ--SSI 95
Cdd:cd14974   9 LIFLLGLPGNGLVIWVAGF-KMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKLNSFVISLNmfASV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEVEQAWIANGSVGEPVIKCEFEKVI 175
Cdd:cd14974  88 FLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSV-PYFVFRDTVTHHNGRSCNLTCVEDYDLRRSRHKA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 176 smeyMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKqlnKKVSASSgdpqkyygKELKIAkslALILFLFALSWLPLHILNC 255
Cdd:cd14974 167 ----LTVIRFLCGFLLPLLIIAICYSVIAVKLRR---KRLAKSS--------KPLRVL---LAVVVAFFLCWLPYHVFAL 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56699444 256 ITLFcpTCQKPSILIYIAIFLTHG----NSAMNPIVYAFRIHKFRVTF 299
Cdd:cd14974 229 LELV--AAAGLPEVVLLGLPLATGlayfNSCLNPILYVFMGQDFRKRL 274
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
40-144 3.64e-07

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 50.69  E-value: 3.64e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  40 LRDATFCFIVSLAVADVaVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQ--SSILALLAIAVDRYLRVKIPLRYKT 117
Cdd:cd15155  31 MRNETAIFMTNLAVSDL-LFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNiyGSMLFLTCISVDRFLAIVYPFRSRT 109
                        90       100
                ....*....|....*....|....*..
gi 56699444 118 VVTQRRAAVAIAGCWILSLVVGLTPMF 144
Cdd:cd15155 110 IRTRRNSAIVCAGVWILVLSGGISASL 136
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
15-299 3.83e-07

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 50.62  E-value: 3.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADvAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQ 92
Cdd:cd15973   6 IYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIAD-ELFMLSVPFLAASAALQHWPFGSamCRTVLSVDGINMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPVIKCEFe 172
Cdd:cd15973  85 TSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVACNLIWPHPAWSAAF- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 kvismeymVYFNFFVWVLPPLLLMVLIYLEVFYLIRkqlnkkVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHI 252
Cdd:cd15973 164 --------VIYTFLLGFLLPVLAIGLCYILIIGKMR------AVALKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYV 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56699444 253 LNCITLFCPtcQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15973 230 VQLLNLFLP--RLDATVNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
21-141 3.89e-07

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 50.69  E-value: 3.89e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  21 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPlAILINI--GPQTYFHT-CL--MVACPVLILTQSSI 95
Cdd:cd15918  12 LVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVP-KMLVNIqtQSKSISYAgCLtqMYFFLLFGDLDNFL 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 56699444  96 LAllAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLT 141
Cdd:cd15918  91 LA--VMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLL 134
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
17-290 4.27e-07

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 50.50  E-value: 4.27e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSS 94
Cdd:cd14964   6 SLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQalCYLIYLLWYGANLAS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNnlseveqawiANGSVGEPVIKCEFEKV 174
Cdd:cd14964  86 IWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKG----------AIPRYNTLTGSCYLICT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 175 ISMEYMVYFNFFVwvLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPqkyyGKELKIAKSLALILFLFALSWLPLHILN 254
Cdd:cd14964 156 TIYLTWGFLLVSF--LLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNT----DKNLKATKSLLILVITFLLCWLPFSIVF 229
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 56699444 255 CITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAF 290
Cdd:cd14964 230 ILHALVAAGQGLNLLSILANLLAVLASTLNPFIYCL 265
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
27-291 5.70e-07

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 50.26  E-value: 5.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  27 NVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLaiLINIGPQTYFHTCLMVACPVLILTQS---SILALLAIAV 103
Cdd:cd15343  18 NSLVIAAVVKNKRFHYPFYYLLANLAAADFFAGIAYVFL--MFNTGPVSKTLTVNRWFLRQGLLDTSlsaSLTNLLVIAV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 104 DRYLRVkIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAwiangsvgepvikCEFEKVISMEYMVYF 183
Cdd:cd15343  96 ERHISI-MRMKVHSNLTKRRVTLLIALVWAIAIFMGAVPTLGWNCICNISAC-------------SSLAPIYSRSYLVFW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 184 NffVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYgKELKIAKSLALILFLFALSWLP-LHILNCITLFCPT 262
Cdd:cd15343 162 S--VSNLVVFLIMVVVYLRIYVYVQRKTNVLSPHTSGSINRRR-TPIKLMKTVMTVLGAFVICWTPgLVVLLLDGLNCTR 238
                       250       260
                ....*....|....*....|....*....
gi 56699444 263 CQKPSILIYIaIFLTHGNSAMNPIVYAFR 291
Cdd:cd15343 239 CGVQHVKRWF-LLLALLNSVMNPIIYSYK 266
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
15-163 5.82e-07

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 50.23  E-value: 5.82e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPG---NVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPL-AILINIGP-QTYFHTCLMVACPVLI 89
Cdd:cd15211   2 LSTVYSFLAVSGtlaNVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQeAVLGSTGTlLVLGYRLFREGLLFLG 81
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56699444  90 LTqSSILALLAIAVDRYLRV-KIPLRYKTVVTQRRAAVAIAGCWILSLVVgLTPMFGWNNLSEVEQAWIANGSVG 163
Cdd:cd15211  82 LT-VSLLSHSLIALNRYVLItKLPAVYQALYQKRNTEWMIALSWALALGL-LLPWLTSFRYPTKSCHDSADGSFA 154
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
18-144 6.55e-07

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 49.79  E-value: 6.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGP-----------QTYFHTCLMVacp 86
Cdd:cd13954   9 LIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGdktisfsgcltQLYFFFSLGG--- 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 56699444  87 vlilTQSSILAllAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMF 144
Cdd:cd13954  86 ----TECFLLA--VMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTV 137
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
18-299 7.02e-07

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 49.84  E-value: 7.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTCLMVACPVLILTQSSI 95
Cdd:cd16004   9 LIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFglEFCRFQNFFPITAMFVSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRaaVAIAGCWILSLVVGLTpmfgwnnlseveQAWIANGSVGEPVIKC--EFEK 173
Cdd:cd16004  89 YSMTAIAADRYMAIIHPFKPRLSAGSTK--VVIAGIWLVALALAFP------------QCFYSTVTMDQGRTKCivAWPG 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 VISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKV--SASSGDPQKYYGKELKIAKSLALILFLFALSWLPLH 251
Cdd:cd16004 155 DSGGKHQLTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVpgHQAHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYH 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444 252 ILNCITLFCPT--CQKPSILIYIAIFLTHGNSAM-NPIVYAFRIHKFRVTF 299
Cdd:cd16004 235 LYFILGSFNEDiyCQKYIQQVYLAIFWLAMSSTMyNPIIYCCLNQRFRSGF 285
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
18-140 7.50e-07

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 49.96  E-value: 7.50e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTclmVACPVL--ILTQS-- 93
Cdd:cd15927   9 LIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGE---FLCKLSefLKDTSig 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 56699444  94 -SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15927  86 vSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAI 133
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
18-136 7.54e-07

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 49.68  E-value: 7.54e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSSI 95
Cdd:cd15914   9 LIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPkmLSNLLSEEKTISFNGCLLQMYFFHSLGITEC 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSL 136
Cdd:cd15914  89 YLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGF 129
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
17-299 9.84e-07

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 49.45  E-value: 9.84e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAI---------LINIGpQTYFHTCLMVacpv 87
Cdd:cd15133   8 LLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELyelwqnypfLLGSG-GCYFKTFLFE---- 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  88 lILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL--TPMFGWNNLseveqawianGSVGEP 165
Cdd:cd15133  83 -TVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALpnTSLHGIKFL----------GSGVPA 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 166 VIKCEFEKVISMEYMVY----FNFFVwvlPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKEL-------KIAK 234
Cdd:cd15133 152 SAQCTVRKPQAIYNMIPqhtgHLFFV---LPMAVISVLYLLMALRLARERGLDATGAGSKIGTRTGQLLqhprtraQVTK 228
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 235 SLALILFLFALSWLPLHILNCITLFCP--TCQKPSILIYIAI---FLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15133 229 MLFILVVVFAICWAPFHIDRLMWSFISdwTDNLHEVFQYVHIisgVFFYLSSAVNPILYNLMSTRFREMF 298
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
18-141 1.00e-06

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 49.38  E-value: 1.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLIL--TQS 93
Cdd:cd15225   9 LIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPkmLVNLLSEDKTISFLGCATQMFFFLFLggTEC 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 56699444  94 SILAllAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLT 141
Cdd:cd15225  89 FLLA--AMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLG 134
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
15-140 1.24e-06

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 49.38  E-value: 1.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAI---------LINIGpQTYFHTCLMVAc 85
Cdd:cd15358   6 TYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELyemwsnypfLLGAG-GCYFKTLLFET- 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444  86 pvliLTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15358  84 ----VCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSI 134
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
19-296 1.27e-06

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 49.12  E-value: 1.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  19 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALviplaiLINIGPQ------TYFHTCLM----VACPVL 88
Cdd:cd15137  10 VGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVY------LLIIASVdlyyrgVYIKHDEEwrssWLCTFA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  89 -----ILTQSSILALLAIAVDRYLRVKIPLRYKTvVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEveqaWIANGSVG 163
Cdd:cd15137  84 gflatLSSEVSVLILTLITLDRFICIVFPFSGRR-LGLRRAIIVLACIWLIGLLLAVLPLLPWDYFGN----FYGRSGVC 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 164 EPvIKCEFEKVISMEYMVyFNFFVWVLPPLLLMVLIYLEVFYLIRKqlnkkvSASSGDPQKyYGKELKIAKSLALILFLF 243
Cdd:cd15137 159 LP-LHITDERPAGWEYSV-FVFLGLNFLAFVFILLSYIAMFISIRR------TRKAAASRK-SKRDMAVAKRFFLIVLTD 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56699444 244 ALSWLPLHILNCITLFCPTCQkPSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15137 230 FLCWIPIIVIGILALSGVPIP-GEVYAWVAVFVLPINSALNPILYTLSTPKFR 281
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
18-140 1.56e-06

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 49.00  E-value: 1.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTY------------FHTCLMVAc 85
Cdd:cd15212   9 AIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWlfgdrlclangfFNACFGIV- 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444  86 pvliltqsSILALLAIAVDRYLRVKIPLRYKtvVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15212  88 --------STLTMTLISFDRYYAIVRQPQGK--IGRRRALQLLAAAWLTALGFSL 132
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
15-299 1.78e-06

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 48.69  E-value: 1.78e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQ-S 93
Cdd:cd15971   6 IYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGINQfT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEVEQAWIANGSVGEPvikcefek 173
Cdd:cd15971  86 SIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVIL-PIMIYAGVQTKHGRSSCTIIWPGE-------- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 viSMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKyygKELKIAKSLALILFLFALSWLPLHIL 253
Cdd:cd15971 157 --SSAWYTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRVGSSKRKK---SEKKVTRMVSIVVAVFVFCWLPFYIF 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56699444 254 NCITL---FCPTCQKPSILIYIAIfLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15971 232 NVSSVsvsISPTPGLKGMFDFVVV-LSYANSCANPILYAFLSDNFKKSF 279
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
15-152 1.98e-06

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 48.72  E-value: 1.98e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVL-----I 89
Cdd:cd15006   5 VQVVIFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLSASPHCCWWIYTLLFCKVIkflhkV 84
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56699444  90 LTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIagCWILSlVVGLTPMFGWNNLSEV 152
Cdd:cd15006  85 FCSVTVLSFAAIALDRYYSVLYPLERKISDAKSRDLVIY--IWAHA-VVASVPVFAVTNVTDI 144
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
17-140 2.28e-06

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 48.19  E-value: 2.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAILINIGPQTYFHTCL------MVACPVLIl 90
Cdd:cd15000   7 LPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLT-LLVCPWMFLVHDFFQNYVLGSVgcklegFLEGSLLL- 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444  91 tqSSILALLAIAVDRYLRVKIPLRYKtvVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15000  85 --ASVLALCAVSYDRLTAIVLPSEAR--LTKRGAKIVIVITWIVGLLLAL 130
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
15-299 2.43e-06

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 48.31  E-value: 2.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSS 94
Cdd:cd15976   6 VSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 I--LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPVIKCEFE 172
Cdd:cd15976  86 ItvLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSIILAVPEAIGFDMITMDYKGELLRICLLHPIQKTAFM 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 KVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYygkelKIAKSLALILFLFALSWLPLHI 252
Cdd:cd15976 166 QFYKTAKDWWLFSFYFCLPLACTAVFYTLMTCEMLRKKNGMQIALNDHLKQRR-----EVAKTVFCLVLVFALCWLPLHL 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444 253 LNCITLFCPTCQKPS---------ILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15976 241 SRILKLTIYDEKDPNrcellsfflVLDYIGINMASLNSCINPIALYLVSKRFKNCF 296
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
19-144 2.88e-06

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 47.94  E-value: 2.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  19 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSSIL 96
Cdd:cd15956  10 IYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPklLAILWFGATAISSYVCLSQMFLVHAFSAMESG 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 56699444  97 ALLAIAVDRYLRVKIPLRYKTVVTQRRaaVAIAGCWILSLVVGLTPMF 144
Cdd:cd15956  90 VLVAMALDRFVAICNPLHYATILTLEV--VAKAGLLLALRGVAIVIPF 135
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
18-296 3.23e-06

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 47.83  E-value: 3.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVaVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQS---S 94
Cdd:cd15088   9 CICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADL-LFMLGMPFLIHQFAIDGQWYFGEVMCKIITALDANNqftS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVgLTPMfgWNNLSEVEqawiANGSVGEPVIKCEFEKV 174
Cdd:cd15088  88 TYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLS-ILPV--WVYSSLIY----FPDGTTFCYVSLPSPDD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 175 IsMEYMVYfNFFVWVLPPLLLMVLIYLevfyLIRKQLNKKVSasSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILN 254
Cdd:cd15088 161 L-YWFTIY-HFILGFAVPLVVITVCYI----LILHRLARGVA--PGNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQ 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 56699444 255 CITLfcpTCQKPS----ILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15088 233 LVNL---AMNRPTlafeVAYFLSICLGYANSCLNPFVYILVSENFR 275
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
22-132 3.42e-06

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 47.84  E-value: 3.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  22 VSVPGNVLVIWAVKVNQALRDA-TFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSSILAL 98
Cdd:cd15935  13 AILLGNLLIVVTVHADPHLLQSpMYFFLANLSLIDMTLGSVAVPkvLADLLTCGRTISFGGCMAQLFFLHFLGGSEMLLL 92
                        90       100       110
                ....*....|....*....|....*....|....
gi 56699444  99 LAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCW 132
Cdd:cd15935  93 TLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACW 126
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
18-144 3.52e-06

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 47.88  E-value: 3.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444    18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCL--MVACPVLILTQS 93
Cdd:pfam13853   3 LMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPtvLGIFWFGLREISFEACLtqMFFIHKFSIMES 82
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 56699444    94 SILalLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMF 144
Cdd:pfam13853  83 AVL--LAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPF 131
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
22-140 4.03e-06

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 47.62  E-value: 4.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  22 VSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQ--SSILALL 99
Cdd:cd16003  13 VAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSvfASIYSMT 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 56699444 100 AIAVDRYLRVKIPLRYKTVVTQRRaaVAIAGCWILSLVVGL 140
Cdd:cd16003  93 AIAVDRYMAIIDPLKPRLSATATK--VVIGSIWILAFLLAF 131
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
18-137 4.34e-06

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 47.25  E-value: 4.34e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVsvpGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTClMVACPVLILTQSSI 95
Cdd:cd15232  12 AAALT---GNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPklLQNLLTERKTISFGGC-MAQLYFFTWSLGSE 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 56699444  96 LALL-AIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLV 137
Cdd:cd15232  88 LLLLtAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGML 130
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
12-125 4.60e-06

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 47.26  E-value: 4.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  12 YIGIEV-LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILI---NIGPQTyFHTCL--MVAC 85
Cdd:cd15953   2 WISIPFcLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIfwfNLKEIT-FSGCLtqMFFI 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 56699444  86 PVLILTQSSILalLAIAVDRYLRVKIPLRYKTVVTQRRAA 125
Cdd:cd15953  81 HTLSIMESAVL--VAMAFDRYVAICNPLRYATILTNSRIA 118
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
12-121 4.93e-06

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 47.46  E-value: 4.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  12 YIGIEVLIA-LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCL--MVACP 86
Cdd:cd15955   2 WIGIPFCIMfLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPkmLAIFWFQLREISFNACLaqMFFIH 81
                        90       100       110
                ....*....|....*....|....*....|....*
gi 56699444  87 VLILTQSSILalLAIAVDRYLRVKIPLRYKTVVTQ 121
Cdd:cd15955  82 TLQAFESGIL--LAMALDRYVAICHPLRHSSILTP 114
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
18-296 4.95e-06

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 47.26  E-value: 4.95e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAILINIG---PQTYFHTCLMVACPVLILTQSS 94
Cdd:cd14982   9 LIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLF-VLTLPFRIYYYLNggwWPFGDFLCRLTGLLFYINMYGS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEVEQAWiangsvgepvIKCEFEKV 174
Cdd:cd14982  88 ILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASV-PLLLLRSTIAKENNS----------TTCFEFLS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 175 ISMEYMVYFNFFVwVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKyygkeLKIAKSLALILFLFALSWLPLHILN 254
Cdd:cd14982 157 EWLASAAPIVLIA-LVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVRK-----RKALRMILIVLAVFLVCFLPYHVTR 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444 255 CITL--------FCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd14982 231 ILYLlvrlsfiaDCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFR 280
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
17-144 6.11e-06

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 47.07  E-value: 6.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALR-DATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVL--ILTQS 93
Cdd:cd15219   7 VVVLVVSLLSNLLVLLCFLYSAELRkQVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLetFLTSN 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMF 144
Cdd:cd15219  87 AMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALF 137
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
18-288 6.27e-06

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 47.05  E-value: 6.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAILINIGPQTYFHTclmVACPVL----ILT-Q 92
Cdd:cd14999   8 LMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLY-LLTIPFYVSTYFLKKWYFGD---VGCRLLfsldFLTmH 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIaGCWILSLVVGLtPMFGWNNLSEVEqawiangSVGEPVIKCEFE 172
Cdd:cd14999  84 ASIFTLTVMSTERYLAVVKPLDTVKRSKSYRKLLAG-VIWLLSLLLTL-PMAIMIRLVTVE-------DKSGGSKRICLP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 KVISMEYMVYFN--FFVWVLPPLLLMVLIYLEvfyLIRKQLnkKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPL 250
Cdd:cd14999 155 TWSEESYKVYLTllFSTSIVIPGLVIGYLYIR---LARKYW--LSQAAASNSSRKRLPKQKVLKMIFTIVLVFWACFLPF 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56699444 251 HILNCITLFCPTCQKPSILI----YIAIFLTHGNSAMNPIVY 288
Cdd:cd14999 230 WIWQLLYLYSPSLSLSPRTTtyvnYLLTCLTYSNSCINPFLY 271
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
21-144 7.45e-06

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 46.90  E-value: 7.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  21 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCL--MVACPVLILTQSSIL 96
Cdd:cd15223  12 LVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPkmLAIFWFDANTISLPGCFaqMFFIHFFTAMESSIL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 56699444  97 alLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILS-LVVGLTPMF 144
Cdd:cd15223  92 --LVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSgLLVLPIVVL 138
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
18-299 7.55e-06

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 46.70  E-value: 7.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADvAVGALVIPLAILINIGPQTYFHTCLmvaCPVLILTQS---- 93
Cdd:cd15094   9 LICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVAD-ECFLIGLPFLIVTMILKYWPFGAAM---CKIYMVLTSinqf 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 -SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWNnlSEVEQAWIANGSVGEPvikcEFE 172
Cdd:cd15094  85 tSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVML-PIILYA--STVPDSGRYSCTIVWP----DSS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 KVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKyygkelKIAKSLALILFLFALSWLPLHI 252
Cdd:cd15094 158 AVNGQKAFTLYTFLLGFAIPLLLISVFYTLVILRLRTVGPKNKSKEKRRSHR------KVTRLVLTVISVYIICWLPYWA 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56699444 253 LNCITLFCPTCQKPSILIyIAIF-----LTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15094 232 FQVHLIFLPPGTDMPKWE-ILMFllltvLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
8-142 8.41e-06

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 46.68  E-value: 8.41e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444   8 FQAAYIGIEVLIALvsvpGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAILINIGPQTYF-HTCLMVACP 86
Cdd:cd15923   3 QYAIYIPTFVLGLL----LNILALWVFCWRLKKWTETNIYMTNLAVADLLL-LISLPFKMHSYRRESAGLqKLCNFVLSL 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444  87 VLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWIlsLVVGLTP 142
Cdd:cd15923  78 YYINMYVSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWV--LVVTISI 131
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
21-140 9.19e-06

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 46.30  E-value: 9.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  21 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPlAILINIGPQ----TYFHTCLMVACPVLILTQSSIL 96
Cdd:cd15236  12 LTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVP-KMLMNMQTQdqsiPYAGCISQMYFFIFFGCLDSFL 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 56699444  97 aLLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15236  91 -LAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHAL 133
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
10-145 1.46e-05

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 45.68  E-value: 1.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAiLINI---GPQTYFHTCLMVACP 86
Cdd:cd15431   1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQM-LVNClsdRPTISYSRCLAQMYI 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56699444  87 VLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFG 145
Cdd:cd15431  80 SLFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLT 138
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
22-120 1.55e-05

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 45.67  E-value: 1.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  22 VSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMvacPVLILTQSSIL--- 96
Cdd:cd15948  14 VALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPkiLSIFWFNSREINFNACLV---QMFFLHSFSIMesa 90
                        90       100
                ....*....|....*....|....
gi 56699444  97 ALLAIAVDRYLRVKIPLRYKTVVT 120
Cdd:cd15948  91 VLLAMAFDRYVAICNPLRYATILT 114
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
18-296 1.55e-05

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 45.83  E-value: 1.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVaVGALVIPL-AILINIGPQTYFHTCL-MVACPVLILTQ-SS 94
Cdd:cd14985   9 AIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADL-VFVLTLPLwATYTANQYDWPFGAFLcKVSSYVISVNMfAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEVEQAWI---------ANGSVGEP 165
Cdd:cd14985  88 IFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSL-PTFLLRSLQAIENLNKtacimlyphEAWHFGLS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 166 VIKCEFEKVISMEYMVYFNFFVWvlpplllmvliylevfylirkqlnKKVSASSGDPQKYYGKELKIAKSLALILFLFAL 245
Cdd:cd14985 167 LELNILGFVLPLLIILTCYFHIA------------------------RSLRKRYERTGKNGRKRRKSLKIIFALVVAFLV 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56699444 246 SWLPLHILNCITLF--------CPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd14985 223 CWLPFHFFKFLDFLaqlgairpCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFR 281
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
19-120 2.18e-05

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 45.54  E-value: 2.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  19 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCL--MVACPVLILTQSS 94
Cdd:cd15949  26 MYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPklLAIFWFSSNEIPLHACLlqMFLIHSFSAIESG 105
                        90       100
                ....*....|....*....|....*.
gi 56699444  95 ILalLAIAVDRYLRVKIPLRYKTVVT 120
Cdd:cd15949 106 IF--LAMAFDRYVAICNPLRHKTILT 129
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
13-137 2.53e-05

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 44.92  E-value: 2.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  13 IGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGalviplaiLINIGPQ-----TYFHTCLMVACPV 87
Cdd:cd15196   4 IAVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVA--------LFNVLPQliwdiTYRFYGGDLLCRL 75
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444  88 LILTQS-----SILALLAIAVDRYLRVKIPLRYKTvVTQRRAAVAIAGCWILSLV 137
Cdd:cd15196  76 VKYLQVvgmyaSSYVLVATAIDRYIAICHPLSSHR-WTSRRVHLMVAIAWVLSLL 129
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
17-299 2.75e-05

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 44.99  E-value: 2.75e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADvAVGALVIPLAILINIGPQTYFHTCLmvaCPVLILTQ---- 92
Cdd:cd15090   8 SIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGNIL---CKIVISIDyynm 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 -SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFgwnnlseveqawIANGSVGEPVIKCEF 171
Cdd:cd15090  84 fTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMF------------MATTKYRQGSIDCTL 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 172 ekVISMEYMVYFNFF-VWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKElKIAKSLALILFLFALSWLPL 250
Cdd:cd15090 152 --TFSHPSWYWENLLkICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR-RITRMVLVVVAVFIVCWTPI 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444 251 HILNCITLFC--PTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15090 229 HIYVIIKALVtiPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
17-140 2.87e-05

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 44.78  E-value: 2.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAI-----------LINIGPQTYFHtcLMVAC 85
Cdd:cd15428   8 LIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLvhllserkiisFIRCAAQLYFF--LSFGI 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444  86 pvlilTQSSILALLAiaVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15428  86 -----TECALLSVMS--YDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSA 133
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
17-299 3.09e-05

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 44.94  E-value: 3.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQ--SS 94
Cdd:cd15125   8 LLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSvgVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFgwnnLSEVEQAWIANGS-----VGEPVIKC 169
Cdd:cd15125  88 VFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAV----FSEVAHIMPDDNTtftacIPYPQTDE 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 EFEKVIS-MEYMVYFnffvwvlPPLLLMVLIYlevFYLIRKQLNKKVSASSGDPQKYYGKEL----KIAKSLALILFLFA 244
Cdd:cd15125 164 MHPKIHSvLIFLVYF-------LIPLAIISIY---YYHIAKTLIKSAHNIPGEYSEHSKRQMetrkRLAKIVLVFVGLFA 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56699444 245 LSWLPLHILNCITLFCPTCQKPS----ILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15125 234 FCWFPNHVLYMYRSFNYNEIDSSlghmIVTLVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
15-140 3.86e-05

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 44.35  E-value: 3.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWaVKVNQALRDATFCFIVSLAVADVAVgALVIPLAILINIGPQTYFH---TCLMVACPVLILT 91
Cdd:cd15372   6 LYTLVFLVGLPANGLALW-VLATQVKRLPSTIFLINLAVADLLL-ILVLPFKISYHFLGNNWPFgegLCRVVTAFFYGNM 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 56699444  92 QSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15372  84 YCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTL 132
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
15-146 3.91e-05

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 44.84  E-value: 3.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTCLMVACPVLILTQ 92
Cdd:cd15403   6 VMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFgaHFCRISAMLYWFFVL 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 56699444  93 SSILALLAIAVDRYLrvkIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGW 146
Cdd:cd15403  86 EGVAILLIISVDRFL---IIVQRQDKLNPHRAKVMIAISWVLSFCISFPSVVGW 136
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
18-138 4.05e-05

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 44.43  E-value: 4.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSSI 95
Cdd:cd15399   9 SIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAvlCHLVPYAQALAVHVST 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKtvVTQRRAAVAIAGCWILSLVV 138
Cdd:cd15399  89 VTLTVIALDRHRCIVYHLESK--ISKKISFLIIGLTWAASALL 129
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
18-137 4.18e-05

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 44.32  E-value: 4.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWaVKVNQALRDATFCFIVSLAVAD----VAVGALVIPLAiLINIGPQTYFhTCLMVACPVLILTQS 93
Cdd:cd15114   9 VVFLVGVPGNALVAW-VTGFEAKRSVNAVWFLNLAVADllccLSLPILAVPIA-QDGHWPFGAA-ACKLLPSLILLNMYA 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLV 137
Cdd:cd15114  86 SVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALL 129
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
13-146 4.48e-05

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 44.28  E-value: 4.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  13 IGIEVLIALVSVPGNVLVIWAVKVNQALRDATF-CFIVSLAVADVAVGALVIPLAILINIGPQTYFHTclmVACPVLILT 91
Cdd:cd15383   4 VAVTFVLFVLSACSNLAVLWSATRNRRRKLSHVrILILHLAAADLLVTFVVMPLDAAWNVTVQWYAGD---LACRLLMFL 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  92 Q-----SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAgcWILSLVVGLTPMFGW 146
Cdd:cd15383  81 KlfamySSAFVTVVISLDRHAAILNPLAIGSARRRNRIMLCAA--WGLSALLALPQLFLF 138
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
17-150 6.08e-05

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 43.94  E-value: 6.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSS 94
Cdd:cd15415   8 LLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPrlLVNFLVEKKTISYSACIAQHFFFAVFVTTE 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLS 150
Cdd:cd15415  88 GFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLS 143
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
7-137 7.13e-05

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 43.85  E-value: 7.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444   7 AFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCL--M 82
Cdd:cd15408  11 ELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPktLLNLLAERKVISFTGCLtqL 90
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444  83 VACPVLILTQSSILAllAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLV 137
Cdd:cd15408  91 YFYAVFATTECYLLA--AMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFL 143
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
18-140 7.52e-05

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 43.42  E-value: 7.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSSI 95
Cdd:cd15237   9 LIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPqmLVHLLSEHKTISFVGCAAQMFFFLALGVTEC 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15237  89 VLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSL 133
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
21-132 7.78e-05

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 43.54  E-value: 7.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  21 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSSILAL 98
Cdd:cd15429  12 LLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPqmLAHFLAEHKTISFASCVAQLFISLALGGTEFILL 91
                        90       100       110
                ....*....|....*....|....*....|....
gi 56699444  99 LAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCW 132
Cdd:cd15429  92 AVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASW 125
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
10-296 8.07e-05

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 43.57  E-value: 8.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIevlIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTCLMVACPV 87
Cdd:cd15073   4 AAYLIV---AGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFgyAGCQWYAFLN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  88 LILTQSSILALLAIAVDRYLRV-KIPLRYKtvVTQRRAAVAIAGCWILSLVVGLTPMFGWNNL-SEVEQA-----WIANG 160
Cdd:cd15073  81 IFFGMASIGLLTVVAVDRYLTIcRPDLGRK--MTTNTYTVMILLAWTNAFFWAAMPLVGWASYaLDPTGAtctinWRKND 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 161 SVgepvikcefekVISMEYMVY-FNFFVWVLPPLLLMVLIYLEVfylirkqlnKKVSASSGDPQKY--YGKELKIAKSLA 237
Cdd:cd15073 159 SS-----------FVSYTMSVIvVNFIVPLAVMFYCYYNVSRFV---------KKVLASDCLESVNidWTDQNDVTKMSV 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56699444 238 LILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15073 219 IMIVMFLVAWSPYSIVCLWASFGEPKKIPPWMAIIPPLFAKSSTFYNPCIYVIANKKFR 277
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
17-295 8.31e-05

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 43.61  E-value: 8.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444   17 VLIALVSVPGNVLVIWaVKVNQALRDATFCFIVSLAVADVaVGALVIPLAILINIGPQTYFHTCL--MVACPVLILTQSS 94
Cdd:PHA03087  48 STIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDL-LFVMTLPFQIYYYILFQWSFGEFAckIVSGLYYIGFYNS 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444   95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVgLTPMFGWNNLSeveqawiangSVGEPVIKCEFEKV 174
Cdd:PHA03087 126 MNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIE-TTPILFVYTTK----------KDHETLICCMFYNN 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  175 ISMEYMVYFNFFVwVLPPLLLMVLIYLEVFYLIRKQLnKKVSASSgdpqkyygKELKIAKSLALILFLFALSWLP----- 249
Cdd:PHA03087 195 KTMNWKLFINFEI-NIIGMLIPLTILLYCYSKILITL-KGINKSK--------KNKKAIKLVLIIVILFVIFWLPfnvsv 264
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 56699444  250 ----LHILNCITLfCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKF 295
Cdd:PHA03087 265 fvysLHILHFKSG-CKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFF 313
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
22-140 8.83e-05

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 43.57  E-value: 8.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  22 VSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQtyFHT----CLMVACPVLILTQSSILA 97
Cdd:cd15197  13 FIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVE--WRAgdfaCKVIRYLQVVVTYASTYV 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 56699444  98 LLAIAVDRYLRVKIPLRYKTvvTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15197  91 LVALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILSALFSI 131
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
18-152 8.94e-05

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 43.36  E-value: 8.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT---------CLMVACPVL 88
Cdd:cd15136   9 FVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYaidwqtgagCKTAGFLAV 88
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56699444  89 ILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEV 152
Cdd:cd15136  89 FSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKT 152
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
17-137 9.24e-05

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 43.63  E-value: 9.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAI--LINIGPQTY------FHTCLMVACpvl 88
Cdd:cd15132   8 LILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLI-LLCLPFDLyrLWKSRPWIFgeflcrLYHYISEGC--- 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 56699444  89 ilTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLV 137
Cdd:cd15132  84 --TYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALL 130
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
15-299 1.06e-04

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 43.28  E-value: 1.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTCLMVACPVLILTQ 92
Cdd:cd15128   6 VSCLIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWPFgdQPFGQFLCKLVPFIQ 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SS-----ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWnNLSEVEQAwiangsvGEPVI 167
Cdd:cd15128  86 KAsvgitVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIGF-DMVRFNYK-------GVTLR 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 168 KCEFEKVIS-MEYMVYFNFFvWVLPPLLLMVLIYLEVFY--LIRKQLNKKvsasSGDPQKYYGKELK----IAKSLALIL 240
Cdd:cd15128 158 TCLLRPETSfMKFYIDVKDW-WLFGFYFCLPLVCTAIFYtlMTCEMLRKR----NGMLRIALNEHLKqrreVAKTVFCLV 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56699444 241 FLFALSWLPLHILNCI--TLFCPT----CQKPSILI---YIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15128 233 VIFALCWLPLHLSRILklTVYDQNdpnrCELLSFLLvldYFGINLATLNSCINPIALYFVSRKFKNCF 300
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
21-120 1.17e-04

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 42.89  E-value: 1.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  21 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILI---NIgPQTYFHTCLMVACPVLILTQSSILA 97
Cdd:cd15954  12 IIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIfwfNL-KEISFNACLVQMFFVHTFTGMESGV 90
                        90       100
                ....*....|....*....|...
gi 56699444  98 LLAIAVDRYLRVKIPLRYKTVVT 120
Cdd:cd15954  91 LMLMALDRYVAICYPLRYATILT 113
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
18-137 1.21e-04

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 42.97  E-value: 1.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAI--LINIGPQTYFHTCLMVACPVLILTQSSI 95
Cdd:cd15939   9 LIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIvdLLSERKTISFNGCMTQLFAEHFFGGAEI 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLV 137
Cdd:cd15939  89 FLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFL 130
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
15-296 1.28e-04

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 43.21  E-value: 1.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAV-KVNQALRDATFCFIVSLAVADVAVgALVIPL-AILINIGPQTYFHT--CLMVACPVLIL 90
Cdd:cd15190  16 IYMLVFVLGLSGNGLVLWTVfRSKRKRRRSADTFIANLALADLTF-VVTLPLwAVYTALGYHWPFGSflCKLSSYLVFVN 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  91 TQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPM-------------------FGWNNLSE 151
Cdd:cd15190  95 MYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALilrttsdlegtnkvicdmdYSGVVSNE 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 152 VEQAWIANGSVGEPVIKCefekVISMEYMVYFNFFVwvlpplllMVLIYLEVFYLIRKQLNKKvsassgdpqkyyGKELK 231
Cdd:cd15190 175 SEWAWIAGLGLSSTVLGF----LLPFLIMLTCYFFI--------GRTVARHFSKLRRKEDKKK------------RRLLK 230
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56699444 232 IaksLALILFLFALSWLPLHILNCITLF---------CPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15190 231 I---IITLVVTFALCWLPFHLVKTLYALmylgilpfsCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFR 301
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
17-288 1.40e-04

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 42.89  E-value: 1.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGAlviplAILINI---GPQTYFHTCLMVACP---VLIL 90
Cdd:cd15348   8 LAVCAFIVLENLIVLLALWRNKKFHSPMFYLLGSLTLSDLLAGA-----AYAANIlmsGANTLKLTPALWFLReggVFIT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  91 TQSSILALLAIAVDRYLRVkIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQawiangsvgepvikCE 170
Cdd:cd15348  83 LTASVFSLLAIAIERHITM-VRMKPYPGDKRGRMFLLIGAAWLVSILLGVLPILGWNCLGNLDA--------------CS 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 171 FEKVISMEYMVYFNFFVWvLPPLLLMVLIYLEVFYLIRKQLNK-----KVSASSGDPQKYygkeLKIAKSLALILFLFAL 245
Cdd:cd15348 148 TVLPLYAKSYILFCITVF-LAILAAIVVLYARIYRIVKANSQRlgalpTRKGRARRSQKY----LALLKTVTIVLGTFVA 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56699444 246 SWLPLHILNCITLFCPTcQKPSILIYIAIFL--THGNSAMNPIVY 288
Cdd:cd15348 223 CWLPLFLLLLLDVSCPA-QACPVLLKADYFLglAMINSLLNPIIY 266
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
18-140 1.47e-04

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 42.82  E-value: 1.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAILINIGPQTYFHTclMVACPVLILT-----Q 92
Cdd:cd15162   9 LVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLL-VIWLPFKIAYHIHGNNWIFG--EALCRLVTVAfygnmY 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15162  86 CSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTL 133
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
47-138 1.55e-04

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 42.63  E-value: 1.55e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  47 FIVSLAVADvavGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRA 124
Cdd:cd15164  38 YMINLAVAD---CCLLFSLPFVLYFLKHSWPDDelCLVLQSIYFINRYMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKA 114
                        90
                ....*....|....
gi 56699444 125 AVAIAGCWILSLVV 138
Cdd:cd15164 115 ALTCGLLWVLVIIS 128
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
18-144 1.61e-04

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 42.47  E-value: 1.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAILINIGPQTYFHTCLMVACPVLILTQ--SSI 95
Cdd:cd14975   9 LAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAV-LLTLPVWIYFLATGTWDFGLAACKGCVYVCAVSmyASV 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGlTPMF 144
Cdd:cd14975  88 FLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLA-TPVI 135
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
18-133 1.81e-04

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 42.64  E-value: 1.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSSI 95
Cdd:cd15231   9 IIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPkmLVNLLRERKTISYIGCLAQLFFFVSFVGTEC 88
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWI 133
Cdd:cd15231  89 LLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWL 126
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
18-143 1.94e-04

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 42.47  E-value: 1.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILInIGPQTYFHTCLMVACPVLILTQSSI 95
Cdd:cd15912   9 LTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPkmLANLL-SGKKTISFAGCFAQSFFYFFLGTTE 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 56699444  96 LALLAI-AVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPM 143
Cdd:cd15912  88 FFLLAVmSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPT 136
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
17-140 1.94e-04

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 42.24  E-value: 1.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVnQALRDATFCFIVSLAVADV---AVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQS 93
Cdd:cd14973   8 VLLSLCGLVGNGLVLWLLGF-RIKRNPFSVYILNLAAADFlflSCQAIQSLEDLLGGSLPGFALCRLLATLMFFSYTVGL 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 56699444  94 SILAllAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd14973  87 SLLA--AISTERCLSVLFPIWYRCHRPKHLSAVVCALLWALSLLLSV 131
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
18-157 1.95e-04

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 42.20  E-value: 1.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVaVGALVIPLAIlINIGPQTYFHT--CLMVACPVLILTQSSI 95
Cdd:cd14984   9 LVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADL-LFVLTLPFWA-VYAADGWVFGSflCKLVSALYTINFYSGI 86
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEVEQAWI 157
Cdd:cd14984  87 LFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSL-PEFIFSQVSEENGSSI 147
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
80-296 2.06e-04

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 42.55  E-value: 2.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  80 CLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAgCWILSLVVGLTPMFGwnnlSEVEQAWIAN 159
Cdd:cd15965  80 CQLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRCLTPGKCRTITILIL-IWIIGFIIAFIPLSN----KEFFRNYYGT 154
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 160 GSVGEPVIKCEFEKVISMEYMVYFnFFVWVLPPLLLMVLIYLEVFYLIRKqlnkkVSASSGDPQKYYGKELKIAKSLALI 239
Cdd:cd15965 155 NGVCFPLHSEQPESTGAQIYSVVI-FLGLNLAAFIIIVFSYGSMFYSIHQ-----TAIMATEISNHIKKEMTLAKRFFFI 228
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 56699444 240 LFLFALSWLPLHILNCITLFcpTCQKP-SILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15965 229 VFTDALCWIPIFILKLLSLL--QVEIPgTISSWVVIFILPINSALNPILYTLTTRPFK 284
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
18-299 2.39e-04

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 42.10  E-value: 2.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFC--FIVSLAVADVAVgALVIPL-AILINIGPQTYFHT--CLMVACPVLILTQ 92
Cdd:cd14976   9 VVFTVGLLGNLLVLYLLKSNKKLRQQSESnkFVFNLALTDLIF-VLTLPFwAVEYALDFVWPFGTamCKVVRYVTKLNMY 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL-TPMFGWNNLseveqawianGSVGEPVIKCEF 171
Cdd:cd14976  88 SSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIpEAIFSTDTW----------SSVNHTLCLLRF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 172 EKVISMEYMVY-----------FNFFVwvlpplllMVLIYLEVFYLIRKQLNKKVSASSGDPQKyygkelkIAKSLALIL 240
Cdd:cd14976 158 PKNSSVTRWYNwlgmyqlqkvvLGFFL--------PLGIITLSYLLLLRFLQRKRGGSKRRKSR-------VTKSVFIVV 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56699444 241 FLFALSWLPLHILNCITLFCPTCQKPSILIY---------IAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd14976 223 LSFFICWLPNQALSLWSALIKFDDVPFSDAFfafqtyafpVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
18-144 2.44e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 42.24  E-value: 2.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIL-INIGPQTYFH--TCLMVACPVLILTQSS 94
Cdd:cd15217   9 LIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVsIRNGSAWTYSvlSCKIVAFMAVLFCFHA 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMF 144
Cdd:cd15217  89 AFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVF 138
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
21-140 2.68e-04

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 41.79  E-value: 2.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  21 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPlAILINIGPQTYFHT---CLMVACPVLILTQSSILA 97
Cdd:cd15234  12 LVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVP-KMLVNIQTQSKSISytgCLTQMCFFLLFGGLDNFL 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 56699444  98 LLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15234  91 LAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSL 133
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
18-139 2.73e-04

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 42.03  E-value: 2.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSSI 95
Cdd:cd15424   9 IIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPqmLAHLLAGNGAISFARCTTQMYIALSLGSTEC 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVG 139
Cdd:cd15424  89 LLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLS 132
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
18-290 2.89e-04

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 41.77  E-value: 2.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVaVGALVIPLAI--LINIGP-QTYFHTCLMVACPVLILTQSS 94
Cdd:cd15194   9 LVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDF-IFLVTLPLWVdkEVVLGPwRSGSFLCKGSSYIISVNMYCS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEVEQAWIANGSVGEPVikcefeKV 174
Cdd:cd15194  88 VFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGL-PTLLSRELKKYEEKEYCNEDAGTPS------KV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 175 ISMEYMVYFNFFVwvlpplllMVLIYLEVFYLIRKQLNKKVSaSSGDPQKYYGKELKIaksLALILFLFALSWLPLHILN 254
Cdd:cd15194 161 IFSLVSLIVAFFL--------PLLSILTCYCTIIWKLCHHYQ-KSGKHQKKLRKSIKI---VFIVVAAFVFSWMPFNLFK 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56699444 255 CITLFC-----PTCQkPSILIYIAIFLT----HGNSAMNPIVYAF 290
Cdd:cd15194 229 ALAIASglqveVTCL-PYTLAQLGMEVSaplaFANSCANPFIYYF 272
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
93-135 3.02e-04

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 41.86  E-value: 3.02e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILS 135
Cdd:cd15170  87 ISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLA 129
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
18-299 3.33e-04

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 41.86  E-value: 3.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPL---AILINIGPQTyfhtclMVACPVLILTQ-- 92
Cdd:cd15091   9 VVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALV-TTTMPFqstVYLMNSWPFG------DVLCKIVISIDyy 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 ---SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEVEQAWIANGSVGEPVIKC 169
Cdd:cd15091  82 nmfTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGI-SAIVLGGTKVREDVDSTECSLQFPDDDY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 170 EFEKVIsMEYMVYFNFFVwvlpplllMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKElKIAKSLALILFLFALSWLP 249
Cdd:cd15091 161 SWWDTF-MKICVFIFAFV--------IPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLR-RITRLVLVVVAVFVVCWTP 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56699444 250 LHILNCITLFCPTCQKPSIL--IYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15091 231 IHIFILVEALGSVSHSTAAVssYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
17-149 4.17e-04

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 41.36  E-value: 4.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSS 94
Cdd:cd15404   8 IFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDafCRVSAMFFWLFVMEG 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444  95 ILALLAIAVDRYLrvkIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNL 149
Cdd:cd15404  88 VAILLIISIDRFL---IIVQKQDKLNPYRAKVLIAVSWAVSFCVAFPLAVGSPDL 139
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
18-296 4.63e-04

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 41.26  E-value: 4.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLmvaCPVLILTQS---- 93
Cdd:cd15397   9 LVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVL---CKMTPFIQCmsvt 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 -SILALLAIAVDRYLRVKIPLRYKTVVTQrrAAVAIAGCWILSLVVGLtPMFGWNNLSEV--EQAWIANGSVGEPVIKCE 170
Cdd:cd15397  86 vSILSLVLIALERHQLIINPTGWKPSVSQ--AYLAVVVIWMLACFISL-PFLAFHILTDEpyKNLSHFFAPLADKAVCTE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 171 F-----EKVISMEYMVYFNFfvwvLPPLLLMVLIYLEVFYLIRKQlnKKVSASSGDPQKYYGKELKIAKSLALILFLFAL 245
Cdd:cd15397 163 SwpsehHKLAYTTWLLLFQY----CLPLLFILVCYLRIYLRLRRR--KDMLERRGEYNRRAGHSKRINVMLVSLVAAFAL 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444 246 SWLPLHILNCITLF----CPTCQKPsiLIYIAIFLTHGNSA-MNPIVYAFRIHKFR 296
Cdd:cd15397 237 CWLPLNVFNAIADWnheaIPHCQHN--LIFSLCHLAAMASTcVNPIIYGFLNSNFK 290
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
18-136 4.69e-04

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 41.38  E-value: 4.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVaVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQ--SSI 95
Cdd:cd15156   9 MVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDL-LFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNmyGSI 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSL 136
Cdd:cd15156  88 LFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVL 128
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
18-141 4.76e-04

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 41.32  E-value: 4.76e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSSI 95
Cdd:cd15233   9 LAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPqmLVHLLSHKRTISYAACLSQLFFFHLLAGADC 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLT 141
Cdd:cd15233  89 FLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALT 134
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
17-137 5.01e-04

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 41.31  E-value: 5.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSS 94
Cdd:cd15944  21 LIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPrmLADFLTKHKVISFSGCATQFAFFVGFVDAE 100
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLV 137
Cdd:cd15944 101 CYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLV 143
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
13-299 5.96e-04

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 41.01  E-value: 5.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  13 IGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLA---ILINIGPqtyFHTCLmvaCPVLI 89
Cdd:cd15092   4 VVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQgtdIFLGFWP---FGNAL---CKTVI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  90 LTQ-----SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFgwnnlseveqawIANGSVGE 164
Cdd:cd15092  77 AIDyynmfTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMV------------MGSAQVED 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 165 PVIKCEFEKVISMEYM-VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQlnKKVSASSGDPQKYYGKElKIAKSLALILFLF 243
Cdd:cd15092 145 EEIECLVEIPTPQDYWdPVFGICVFLFSFIIPVLIISVCYSLMIRRL--RGVRLLSGSKEKDRNLR-RITRLVLVVVAVF 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 56699444 244 ALSWLPLHILNCITL--FCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15092 222 VGCWTPIQIFVLAQGlgVQPSSETAVAILRFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
18-144 6.13e-04

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 40.76  E-value: 6.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPlAILINIGPQT---YFHTCLMVACPVLILTQSS 94
Cdd:cd15913   9 VIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVP-NMLVNFLSETktiSFSGCFLQFYFFFSLGTTE 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMF 144
Cdd:cd15913  88 CFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVV 137
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
18-133 7.17e-04

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 40.78  E-value: 7.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSSI 95
Cdd:cd15936   9 LVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPkmLSDLLSQTKTISFNGCMAQMFFFHFTGGAEV 88
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWI 133
Cdd:cd15936  89 FLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWL 126
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
15-299 7.18e-04

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 40.61  E-value: 7.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTCLMVACPVLILTQ 92
Cdd:cd15975   6 LSCIIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFddSSFGVFLCKLVPFLQ 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SS-----ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQawiangsvGEPVI 167
Cdd:cd15975  86 KAsvgitVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIFSIWVLSFILAIPEAIGFVMVPFEYN--------GEQYR 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 168 KCEFEKviSMEYMVYFNFFV--WVLPPLLLMVLIYLEVFYLIR--KQLNKKVSASSGDPQKYYGKELKIAKSLALILFLF 243
Cdd:cd15975 158 TCMLNA--TTKFMNFYVDAKdwWLFGFYFCVPLACTAIFYTLMtcEMLNRRKGSLRIALSEHLKQRREVAKTVFCLVVIF 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56699444 244 ALSWLPLHILNCI--TLFCPT----CQKPSILI---YIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15975 236 ALCWFPLHLSRILkkTVYNENdprrCELLSFLLvmdYISINLATMNSCINPIALYFVSKKFKNCF 300
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
18-299 7.76e-04

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 40.70  E-value: 7.76e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADvAVGALVIPLAILINIGPQTYFHTCLmvaCPVLILTQ----- 92
Cdd:cd15089   9 VVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSAKYLMETWPFGELL---CKAVLSIDyynmf 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPVIkceFE 172
Cdd:cd15089  85 TSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRDGAVVCMLQFPSPSW---YW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 KVISMEYMVYFNFFVwvlpplllmVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKElKIAKSLALILFLFALSWLPLHI 252
Cdd:cd15089 162 DTVTKICVFIFAFVV---------PILVITVCYGLMILRLRSVRLLSGSKEKDRNLR-RITRMVLVVVAAFIICWTPIHI 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444 253 LNCITLFCPTCQKPSILI---YIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15089 232 FVIVWTLVDIDRRNPLVVaalHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
17-133 8.11e-04

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 40.49  E-value: 8.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSS 94
Cdd:cd15942   8 LVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPkvIAGFLSGGRIISFGGCVTQLFFFHFLGCAE 87
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWI 133
Cdd:cd15942  88 CFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWL 126
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
18-163 8.98e-04

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 40.46  E-value: 8.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAILINI-GPQTYFH--TCLMVACPVLILTQSS 94
Cdd:cd15161   9 LVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSY-VLILPMRLVYHLsGNHWPFGevPCRLAGFLFYLNMYAS 87
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILsLVVGLTPMFG------WNNLSEVEQAWIANGSVG 163
Cdd:cd15161  88 LYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVI-VTVAMAPLLVspqtveVNNTTVCLQLYREKASRG 161
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
18-296 9.30e-04

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 40.22  E-value: 9.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGalVIPLAILINIGPQTYFHT----CLMVACPVLILTQS 93
Cdd:cd15085   9 LNATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMA--LCGTTIVTVTNYEGYFYLgdafCIFQGFAVNYFGIV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTqRRAAVAIAGCWILSLVVGLTPMFGWNnlseveqAWIANGSVGEPVIKCEFEK 173
Cdd:cd15085  87 SLWSLTLLAYERYNVVCKPMGGLKLST-KRGYQGLLFIWLFCLFWAVAPLFGWS-------SYGPEGVQTSCSIGWEERS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 VISMEYMVYFnFFVWVLPPLLLMVLIYLEVFYLIRkQLNKKVSASSGDPQKYygKELKIAKSLALILFLFALSWLPLHIL 253
Cdd:cd15085 159 WSNYSYLILY-FLMCFVIPVAIIGFSYGNVLRSLH-KLNKKIEQQGGKNCPE--EEERAVIMVLAMVIAFLICWLPYTVF 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 56699444 254 NCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15085 235 ALIVVVNPELSISPLAATMPTYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
17-145 9.34e-04

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 40.16  E-value: 9.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGAlVIPLAILINIGPQTYFH---TCLMVACPVLILTQS 93
Cdd:cd15366   8 IIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIA-TLPLWIDYFLHRDNWIHgpeSCKLFGFIFYTNIYI 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFG 145
Cdd:cd15366  87 SIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSAPLFH 138
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
20-122 1.08e-03

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 39.88  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444    20 ALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTC-LMVACPVLILTQSSILaL 98
Cdd:pfam10320   1 SVIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVVLLFTGTQLTRNECfWMISFYIFGQTAQGPL-M 79
                          90       100
                  ....*....|....*....|....
gi 56699444    99 LAIAVDRYLRVKIPLRYKTVVTQR 122
Cdd:pfam10320  80 LMIGIDRLIAVKFPIFYRLLSSSK 103
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
21-296 1.15e-03

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 40.10  E-value: 1.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  21 LVSVPGNVLVIWAVKVNQALRDATFCFIvSLAVADVAVGALVIPLAILINIGPQTYFH--TCLMVACPVLILTQSSILAL 98
Cdd:cd15117  12 VLGTLGNGLVIWVTGFRMTRTVTTVCFL-NLAVADFAFCLFLPFSVVYTALGFHWPFGwfLCKLYSTLVVFNLFASVFLL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  99 LAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMF-----GWNNLSEVEQAWIA-NGSVGEPVIKCEFE 172
Cdd:cd15117  91 TLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVfrdtrKENGCTHCYLNFDPwNETAEDPVLWLETV 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 kVISMEYMVYFNFFVWVLPPLLLMVLIYlevfYLIRKQLNKKVSASSGDPQKYYGkelkiakslaLILFLFALSWLPLHI 252
Cdd:cd15117 171 -VQRLSAQVITRFVLGFLVPLVIIGGCY----GLIAARLWREGWVHSSRPFRVLT----------AVVAAFFLCWFPFHL 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444 253 LNCITLFCPTCQKP------SILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15117 236 VSLLELVVILNQKEdlnpllILLLPLSSSLACVNSCLNPLLYVFVGRDFR 285
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
19-296 1.18e-03

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 39.81  E-value: 1.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  19 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHT--CLMVACPVLILTQSSIL 96
Cdd:cd15078  10 IGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVagCVWDGFSNSLFGIVSIM 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  97 ALLAIAVDRYLRVKiplrYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLS-EVEQawiangsvgepvIKCEFE--- 172
Cdd:cd15078  90 TLTVLAYERYIRVV----HAKVVNFSWSWRAITYIWLYSLAWTGAPLLGWNRYTlEVHG------------LGCSFDwks 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 KVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKqLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHI 252
Cdd:cd15078 154 KDPNDTSFVLLFFLGCLVVPLGIMAYCYGHILYEIRM-LRSVEDLQTFQVIKILKYEKKVAKMCLLMISTFLICWMPYAV 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56699444 253 LNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15078 233 VSLLVTSGYSKLVTPTIAIIPSLFAKSSTAYNPVIYIFMIRKFR 276
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
15-296 1.20e-03

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 40.09  E-value: 1.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIwAVKVNQALR---DATFCFIVSLAVADVAVGALVIPL---AILINIGPQTYFHTCLMVACPVL 88
Cdd:cd15002   5 LLGVICLLGFAGNLMVI-GILLNNARKgkpSLIDSLILNLSAADLLLLLFSVPFraaAYSKGSWPLGWFVCKTADWFGHA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  89 ILTQSSILaLLAIAVDRYLRVKIPLRYKTVvTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEVEQAWIANGSVgePVIK 168
Cdd:cd15002  84 CMAAKSFT-IAVLAKACYMYVVNPTKQVTI-KQRRITAVVASIWVPACLLPL-PQWLFRTVKQSEGVYLCILCI--PPLA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 169 CEFEKVISMEYMVyFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGdpqkyygkelKIAKSLALILFLFALSWL 248
Cdd:cd15002 159 HEFMSAFVKLYPL-FVFCLPLTFALFYFWRAYGQCQRRGTKTQNLRNQIRSR----------KLTHMLLSVVLAFTILWL 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56699444 249 PLHILNcITLFCPTCQKPSILIYIAIF---LTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15002 228 PEWVAW-LWLIHIKSSGSSPPQLFNVLaqlLAFSISSVNPIIFLLMSEEFR 277
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
21-134 1.41e-03

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 39.64  E-value: 1.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  21 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCL--MVACPVLILTQSSIL 96
Cdd:cd15951  12 AVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPkmLSIFWFNSREIDFSACLtqMFFIHSFSTMESGIF 91
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 56699444  97 alLAIAVDRYLRVKIPLRYKTVVTqrRAAVAIAGCWIL 134
Cdd:cd15951  92 --VAMALDRYVAICNPLRHSTILT--NSVVAKIGLAVV 125
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
10-132 1.71e-03

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 39.47  E-value: 1.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPV 87
Cdd:cd15938   1 ALLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPkmLVDFLSQRKAISYEACIAQLFFL 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 56699444  88 LILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCW 132
Cdd:cd15938  81 HFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASW 125
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
13-144 1.73e-03

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 39.41  E-value: 1.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  13 IGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAILINIGPQTYFHTCLMVACPVL--IL 90
Cdd:cd15121   4 IAILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAV-LLTAPFFLHFLSGGGWEFGSVVCKLCHYVcgVS 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 56699444  91 TQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMF 144
Cdd:cd15121  83 MYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPF 136
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
18-290 1.76e-03

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 39.40  E-value: 1.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAV--KVNQALRDATFCFIVSLAVADVAVgALVIPLAILInIGPQTYFH---TCLMVACPVLILTQ 92
Cdd:cd15122   9 LAALLGLPGNGFIIWSIlwKMKARGRSVTCILILNLAVADGAV-LLLTPFFITF-LTRKTWPFgqaVCKAVYYLCCLSMY 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFgwnnLSEVEQAWIANGSVGEPVIKCEFE 172
Cdd:cd15122  87 ASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFV----YRHVWKDEGMNDRICEPCHASRGH 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 KV--ISMEYMVYFnffvwvlpplLLMVLIYLEVFYLIRKQLNKKvsassgdpqkYYGKELKIAKSLALILFLFALSWLPL 250
Cdd:cd15122 163 AIfhYTFETLVAF----------VLPFGVILFSYSVILVRLKGA----------RFRRRARVEKLIAAIVVAFALLWVPY 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56699444 251 HILNCITLF-CPTCQKPS--------ILIYIAIFLTHGNSAMNPIVYAF 290
Cdd:cd15122 223 HVVNLLQVVaNLAPGEVLeklggaakAARAGATALAFFSSSVNPLLYVF 271
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
17-140 1.82e-03

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 39.34  E-value: 1.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILinigpqtYFHTCLMVA----CPVLILTQ 92
Cdd:cd15384   8 AVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAI-------WAYTVAWLAgntmCKLVKYLQ 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 56699444  93 S-----SILALLAIAVDRYLRVKIPLryKTVVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15384  81 VfglylSTYITVLISLDRCVAILYPM--KRNQAPERVRRMVTVAWILSPIFSI 131
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
18-140 1.96e-03

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 39.36  E-value: 1.96e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAI---LINIGP--------QTYFHTCLmVACP 86
Cdd:cd15227   9 LIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIansLTNTRSisflgcvaQVFLFIFF-AASE 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 56699444  87 VLILTqssilallAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15227  88 LALLT--------VMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGA 133
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
93-144 2.03e-03

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 39.31  E-value: 2.03e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRyKTVVTQRRAAVAIAGC-WILsLVVGLTPMF 144
Cdd:cd15378  85 SSILFLTFISIDRYLLIKYPFR-EHILQKKRSAVAISLAiWVL-VTLELLPIL 135
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
18-140 2.11e-03

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 39.22  E-value: 2.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSSI 95
Cdd:cd15411   9 VIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPkaLENFLSGRKAISFAGCFVQMYFFIALATTEC 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15411  89 FLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSL 133
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
12-143 2.14e-03

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 39.08  E-value: 2.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  12 YIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCF---IVSLAVADVavgaLVIPLAILINIGPQTYFHTCLMVACPVL 88
Cdd:cd15356   3 FTAVYALIWALGAAGNALTIHLVLKKRSLRGLQGTVhyhLVSLALSDL----LILLISVPIELYNFVWFHYPWVFGDLVC 78
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56699444  89 --------ILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPM 143
Cdd:cd15356  79 rgyyfvrdICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFAL-PM 140
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
15-299 2.33e-03

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 39.12  E-value: 2.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYF--HTCLMVACPVLILTQ 92
Cdd:cd15977   6 LSCVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFgvHVCKLYPFIQKASVG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWnNLSEVEQAwiangsvGEPVIKCEFE 172
Cdd:cd15977  86 ITVLSLCALSIDRYRAVASWSRIRGIGIPVWKAVEVTLIWAVAIIVAVPEAIAF-DMVEIDYR-------GQTLLVCMLP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 173 KVISMEYMVYFNFFV--WVLPPLLLMVLIYLEVFY-LIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLP 249
Cdd:cd15977 158 MEQTSSFMRFYQDVKdwWLFGFYFCLPLACTGVFYtLMSCEMLSIKNGMRIALNDHMKQRREVAKTVFCLVVIFALCWLP 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56699444 250 LHILNCITLFCPTCQKPS---------ILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15977 238 LHLSRILKKTIYDVKDPQrcellsfllVMDYTGINMASLNSCINPVALYFVSRKFKNCF 296
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
18-296 2.37e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 39.01  E-value: 2.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIgpQTYF----HTCLMVACPVLILTQS 93
Cdd:cd15082  22 VVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNA--RGYFflgvWACVLEGFAVTFFGIV 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPLRyKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQawianGSVGEPvikcEFEK 173
Cdd:cd15082 100 ALWSLAVLAFERFFVICRPLG-NIRLQGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKI-----GTTCEP----NWYS 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 174 VISMEYMVYFNFFVwvLPPLLLMVLIYLEVFYLIRKQlnKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHIL 253
Cdd:cd15082 170 GNMHDHTYIITFFT--TCFILPLGVIFVSYGKLLQKL--RKVSNTQGRLGNARKPERQVTRMVVVMIVAFMVCWTPYAAF 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 56699444 254 NCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15082 246 SILVTAHPTIHLDPRLAAIPAFFSKTAAVYNPIIYVFMNKQFR 288
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
17-143 2.37e-03

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 38.98  E-value: 2.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAILINIGPQTYFH---TCLMVACPVLILTQS 93
Cdd:cd15369   8 TIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLF-VLLLPFKIAYHFSGNDWLFgeaMCRVVTAAFYCNMYC 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444  94 SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLvVGLTPM 143
Cdd:cd15369  87 SILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSI-AGVVPL 135
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
18-299 2.39e-03

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 39.02  E-value: 2.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALR---DATFCFIVSLAVADVaVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSS 94
Cdd:cd15338   9 VICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDL-LFLLGMPFLIHQLLGNGVWHFGETMCTLITALDTNSQ 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILA---LLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLvVGLTPMFGWNNLSEVEqawiaNGSVGEPVIKCEF 171
Cdd:cd15338  88 ITStyiLTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSL-LSITPVWMYAGLMPLP-----DGSVGCALLLPNP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 172 EKviSMEYMVYFNFFVWVLPPLLLMVLIYlevfyliRKQLNKKVSASSGDPQKYYG-KELKIAKSLALILFLFALSWLPL 250
Cdd:cd15338 162 ET--DTYWFTLYQFFLAFALPLVVICVVY-------FKILQNMASTVAPLPQRSLRvRTKKVTRMAVAICLAFFICWAPF 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56699444 251 HILNCITLfcpTCQKPSILIY----IAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15338 233 YILQLAHL---SIDRPSLAFLyaynVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
21-133 2.41e-03

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 39.05  E-value: 2.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  21 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILinigPQTYFHTCL-MVACPVLILTQS-----S 94
Cdd:cd15008  11 LVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLL----QFTSGRWTLgSAMCKLVRYFQYltpgvQ 86
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKtvVTQRRAAVAIAGCWI 133
Cdd:cd15008  87 IYVLLSICVDRFYTIVYPLSFK--VSREKAKKMIAASWL 123
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
21-137 2.60e-03

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 38.95  E-value: 2.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  21 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLaILINI--GPQTYFHTCLMVACPVL-ILTQSSILA 97
Cdd:cd15937  12 LIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPK-MLADFfsERKTISYGGCMAQLFFLhFLGAAEMFL 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 56699444  98 LLAIAVDRYLRVKIPLRYKTVVTQRraavaiaGCWILSLV 137
Cdd:cd15937  91 LVAMAYDRYVAICKPLHYTTVVNRR-------VCCVLVGA 123
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
18-141 2.72e-03

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 38.79  E-value: 2.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSSI 95
Cdd:cd15410  22 AIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPkmLVNFLAEDKAISYSGCMLQFFFFCTFVVTES 101
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLT 141
Cdd:cd15410 102 FLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLI 147
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
18-138 3.40e-03

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 38.54  E-value: 3.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVnQALRDATFCFIVSLAVADVAVgALVIPLAILINIGPQTYFHTCLMVACPVLIL-----TQ 92
Cdd:cd15110   9 IICLLGLVGNGIVLWFLGF-RIRRNPFTVYILHLAIADFTF-LLCIFILSIMYIGPFNFSHSRDYVAMLIFIIlflfgYN 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVV 138
Cdd:cd15110  87 TGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAIVCGLLWALSVLM 132
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
22-149 3.56e-03

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 38.60  E-value: 3.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  22 VSVPGNVLVIWAV-KVNQALRDATFCFIVSLAVADVAVGALVI------PLAILINIGPQTYFHTclmVACPVLILTQSS 94
Cdd:cd15129  13 LGLPVNILTAVALsRLAVRTKKSSYYYLLALTASDILTQVFIIfvgfilQTAILAREVPHALIHT---VSVLEFAANHAS 89
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWNNL 149
Cdd:cd15129  90 IWITVLLTVDRYVALCHPLRYRAVSYPERTRRIIAAVFVAALATGI-PFYWWSDM 143
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
18-143 3.74e-03

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 38.52  E-value: 3.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVaVGALVIPLAILINIGPQTY---FHTCLMVACPVLILTQSS 94
Cdd:cd15148   9 LIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADL-LLIICLPFRILYHVNNNQWtlgPLLCKVVGNLFYMNMYIS 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLvVGLTPM 143
Cdd:cd15148  88 IILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVAL-VGFVPM 135
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
18-299 3.80e-03

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 38.57  E-value: 3.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADvAVGALVIPLAILINIGPQTYFHTCLmvaCPVLILTQ----- 92
Cdd:cd15087   9 VICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIAD-DLFTLVLPINIAEHLLQQWPFGELL---CKLILSIDhynif 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVV--TQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEVEQAWIANGSVGEPVIKCE 170
Cdd:cd15087  85 SSIYFLTVMSVDRYLVVLATVRSRRMPyrTYRAAKIVSLCVWLLVTIIVL-PFTVFAGVYSNELGRKSCVLSFPSPESLW 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 171 FEKviSMEYMVYFNFFVWVLPplllmvliyLEVFYLIRKQLNKKVSASSGdpqkyyGKELKIAKSLALILFLFALS---- 246
Cdd:cd15087 164 FKA--SRIYTLVLGFAIPVST---------ICILYTMMLYKLRNMRLNSN------AKALDKAKKKVTLMVLVVLAvclf 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56699444 247 -WLPLHILNCITLFCPTCQKPSILI--YIAIFLTHGNSAMNPIVYAFRIHKFRVTF 299
Cdd:cd15087 227 cWTPFHLSTVVALTTDLPQTPLVIGisYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
13-154 4.47e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 38.24  E-value: 4.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  13 IGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGalviplaiLINIGPQ-----TYFHTCLMVACPV 87
Cdd:cd15386   4 IGVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVA--------LFQVLPQliweiTYRFQGPDLLCRA 75
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56699444  88 LILTQ-----SSILALLAIAVDRYLRVKIPLRyktVVTQ--RRAAVAIAGCWILSLVVGLTPMFGWnNLSEVEQ 154
Cdd:cd15386  76 VKYLQvlsmfASTYMLIMMTVDRYIAVCHPLR---TLQQpsRQAYLMIGATWLLSCILSLPQVFIF-SLREVDQ 145
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
18-138 4.55e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 38.13  E-value: 4.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTY---FHTCLMVACPVLILTQSS 94
Cdd:cd14986   9 VLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVagdVLCRIVKYLQVVGLFAST 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 56699444  95 ILaLLAIAVDRYLRVKIPLryKTVVTQRRAAVAIAGCWILSLVV 138
Cdd:cd14986  89 YI-LVSMSLDRYQAIVKPM--SSLKPRKRARLMIVVAWVLSFLF 129
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
18-154 4.63e-03

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 38.24  E-value: 4.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAIL--INIGPqtyFHTCLMVACPVLILTQSSI 95
Cdd:cd15920   9 IICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLL-VLCLPFRVAyqNTAGP---LSFCKIVGAFFYLNMYASI 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQ 154
Cdd:cd15920  85 LFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLFESRNEGPCDN 143
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
14-141 4.70e-03

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 38.06  E-value: 4.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  14 GIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILT 91
Cdd:cd15915   5 VLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPkmLAGLLSEHKTISFQGCISQLHFFHFLG 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444  92 QSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLT 141
Cdd:cd15915  85 SSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALM 134
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
26-135 4.95e-03

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 38.18  E-value: 4.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  26 GNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAV 103
Cdd:cd15228  17 GNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPkmLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLLYTVMAY 96
                        90       100       110
                ....*....|....*....|....*....|..
gi 56699444 104 DRYLRVKIPLRYKTVVTQRRAAVAIAGCWILS 135
Cdd:cd15228  97 DRYVAICHPLRYLLIMNRRVCALLAAGTWITS 128
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
15-296 4.96e-03

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 37.83  E-value: 4.96e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  15 IEVLIALVSVPGNVLVIWAVKVNQAlRDATFCFIVSLAVADVaVGALVIPLAI----LINIGPQTYFhTCLMVACPVLIL 90
Cdd:cd15115   6 VLSLTFLLGVPGNGLVIWVAGLKMK-RTVNTIWFLNLAVADL-LCCLSLPFSIahllLNGHWPYGRF-LCKLLPSIIVLN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  91 TQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLtPMFGWNNLSEveqawiangSVGEPVIKCE 170
Cdd:cd15115  83 MFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCL-PVFIYRTTVT---------DGNHTRCGYD 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444 171 FEKVISMEYMVyFNFFVwvlpplllmVLIYLEVFYLIrkqLNKKVSASSGdpQKYYGKELKIAkslALILFLFALSWLPL 250
Cdd:cd15115 153 FLVAITITRAV-FGFLL---------PLLIIAACYSF---IAFRMQRGRF--AKSQSKTFRVI---IAVVVAFFVCWAPY 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56699444 251 HILNCITLFC-PTCQKPSILI-YIAIFLTHGNSAMNPIVYAFRIHKFR 296
Cdd:cd15115 215 HIIGILSLYGdPPLSKVLMSWdHLSIALAYANSCLNPVLYVFMGKDFK 262
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
17-140 5.00e-03

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 38.11  E-value: 5.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVaVGALVIPLAIlinigpqTYFHT--------CLMVACPVL 88
Cdd:cd15182   8 YLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDL-LFTFTLPFWA-------SYHSSgwifgeilCKAVTSIFY 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 56699444  89 ILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15182  80 IGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASL 131
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
14-140 5.03e-03

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 38.08  E-value: 5.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  14 GIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILT 91
Cdd:cd15420   5 GLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPhmLGNLLKQRKTISFAGCGTQMYLFLALA 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 56699444  92 QSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15420  85 HTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLAL 133
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
18-137 5.43e-03

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 37.78  E-value: 5.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCL--MVACPVLILTQS 93
Cdd:cd15407   9 LIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPkvMAGLLTGDKVISYNACAaqMFFFVVFATVEN 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 56699444  94 SILAllAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLV 137
Cdd:cd15407  89 FLLA--SMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFL 130
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
17-144 5.86e-03

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 37.65  E-value: 5.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLMVACPVLILTQSS 94
Cdd:cd15224   8 LIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPklLAGFLSQNKSISFVGCMTQLYFFLSLACTE 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 56699444  95 ILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMF 144
Cdd:cd15224  88 CVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVY 137
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
17-132 6.85e-03

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 37.52  E-value: 6.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWAVKVNQALRD-ATFCFIVSLAVADVAVGALVIP--LAILINIGPQTY-FHTCLMVACPVLILTQ 92
Cdd:cd15941   8 LLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPkvLAGLLTLSGRTIsFEGCVVQLYAFHFLAS 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCW 132
Cdd:cd15941  88 TECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTW 127
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
18-137 7.47e-03

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 37.57  E-value: 7.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAI--LINIGPQTYFHTCLMVACPVLILTQSSI 95
Cdd:cd15226   9 LFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMIcdLLREHKTISFGGCMAQIFFLHFFGGSEM 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 56699444  96 LALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLV 137
Cdd:cd15226  89 VLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFI 130
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
17-138 7.98e-03

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 37.36  E-value: 7.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  17 VLIALVSVPGNVLVIWaVKVNQALRDATF-CFIVSLAVADVaVGALVIPLAILINIGPQTYFH---TCLMVACPVLILTQ 92
Cdd:cd15160   8 SFVFVVGLPANCLALW-VLYLQIKKENVLgVYLLNLSLSDL-LYILTLPLWIDYTANHHNWTFgplSCKVVGFFFYTNIY 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 56699444  93 SSILALLAIAVDRYLRVKIPLRYKTVVTqRRAAVAIAGC-WILSLVV 138
Cdd:cd15160  86 ASIGFLCCIAVDRYLAVVHPLRFRGLRT-RRFALKVSASiWVLELGT 131
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
18-140 8.47e-03

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 37.38  E-value: 8.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  18 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAILINIGPQTYFHTCLmVACPV---LILTQ 92
Cdd:cd15412   9 VIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPkmLVNFLSEKKTISFAGCF-TQCYFfiaLVITE 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 56699444  93 SSILAllAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGL 140
Cdd:cd15412  88 YYMLA--VMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGL 133
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
14-133 9.12e-03

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 37.43  E-value: 9.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444  14 GIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTY---FHTCLMVACPVLIL 90
Cdd:cd15916   5 LIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGGKvisFGGCVAQLYFFHFL 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 56699444  91 TQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWI 133
Cdd:cd15916  85 GSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWV 127
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
7-138 9.71e-03

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 37.06  E-value: 9.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56699444   7 AFQAAYIGIEVLIALVsvpGNVLVIWAVKVNQALRDATFCFIVSLAVADvavgalvipLAILINIGPQTYFHTCLMV--- 83
Cdd:cd15200   1 AFLAPVLGIEFVLGLV---GNGIALFIFCFHRRPWKSNTMYLLSLVVAD---------FFLIINLPFRIDYYLRNEVwrf 68
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56699444  84 ---ACPVLILTQS-----SILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVV 138
Cdd:cd15200  69 gatACQVNLFMLSmnrtaSIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLL 131
7tmA_GPR153_GPR162-like cd14998
orphan G protein-coupled receptors 153 and 162, member of the class A family of ...
90-151 9.89e-03

orphan G protein-coupled receptors 153 and 162, member of the class A family of seven-transmembrane G protein-coupled receptors; This group contains the G-protein coupled receptor 153 (GPR153), GPR162, and similar proteins. These are orphan GCPRs with unknown endogenous ligand and function. GPR153 and GPR163 are widely expressed in the central nervous system (CNS) and share a common evolutionary ancestor due to a gene duplication event. Although categorized as members of the rhodopsin-like class A GPCRs, both GPR162 and GPR153 contain an HRM-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors which is important for efficient G protein-coupled signal transduction. Moreover, the LPxF motif, a variant of NPxxY motif that plays a crucial role during receptor activation, is found at the end of TM7 in both GPR162 and GPR153. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320129  Cd Length: 301  Bit Score: 37.22  E-value: 9.89e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56699444  90 LTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSE 151
Cdd:cd14998  86 LTLATCFTVTSLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHDNSE 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH