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Conserved domains on  [gi|83715968|ref|NP_001008392|]
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coiled-coil domain-containing protein 73 [Homo sapiens]

Protein Classification

RluA family pseudouridine synthase( domain architecture ID 12174983)

RluA family pseudouridine synthase catalyzes the isomerization of specific uridines in rRNA or tRNA to pseudouridines

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CCDC73 pfam15818
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ...
26-1072 0e+00

Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.


:

Pssm-ID: 464893 [Multi-domain]  Cd Length: 1048  Bit Score: 1568.40  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     26 QLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEK 105
Cdd:pfam15818    1 QLLDFKTSLLEALEELRMRREAETQYEEQIGKIIVETQELKWQKETLQNQKETLAKQHKEAMAVFKKQLQMKMCALEEEK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    106 GKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKL 185
Cdd:pfam15818   81 GKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKLQLHLLAKEDHHKQLNEIEKYYATITGQFGLVKENHGKL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    186 EQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEK 265
Cdd:pfam15818  161 EQNVQEAIQLNKRLSALNKKQESEICSLKKELKKVTSDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNKK 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    266 INEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALG 345
Cdd:pfam15818  241 INEEITHIQEEKQDIIISFQHMQQLLQQQTQANTEMEAELKALKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALG 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    346 TWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQE 425
Cdd:pfam15818  321 TWKKHVEELNGEINEIKNELSSLKETHIKLQEHYNKLCNQKKFEEDKKFQNVPEVNNENSEMSTEKSENLIIQKYNSEQE 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    426 IREENMENFCSDTEYReKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNV 505
Cdd:pfam15818  401 IREENTKSFCSDTEYR-ETEKKKGPPVEEIIIEDLQVLEKSFKNEIDTSVPQDKNQSEISLSKTLCTDKDLISQGQTLNV 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    506 TDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILNETAH 585
Cdd:pfam15818  480 TDFRKSVTTEIKDKLCLEKDNGCSEFKSPNNLFLVADQSIETEKIHLESTEGLGLHHADIHLETESNRSSFNGTLNEMAH 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    586 NTYHnnNKDVSENEPFK-QFRLLPGTREHALEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKq 664
Cdd:pfam15818  560 NTNH--NKDVSENEPFKqQFRLLLCTQENATEKRITNSDQTKAGLDSSLDVKKNPVQCQKYSLQDSSNVSLDDKQCKIE- 636
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    665 iQLLTKKSECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSKLLLKNSDKNVHSMSMLVKPNSSPG 744
Cdd:pfam15818  637 -QLLNKKSECSTLPLKQTSSFQQLCNDTSEKPGLTIPCDTVVSHPISPAAFSDNLKADLKNSDNNVNIMPMLVKPNSSPG 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    745 GKTMCKNMSDMQNSQFNNCLGYLENtNVNISHLHLNNENSHASQAKDVKTAVHMKTCTETEFSNKKNQIDENQVTEATKN 824
Cdd:pfam15818  716 KRTTRKNLDDMQSSQFKNCLGGLEN-GVTISHLQVNNENSHASQAKDLKTAVHPKTSTEIQFSSKESQIDENQITEATKN 794
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    825 DLFLFVSINERQHTLLNNTEKTESLNDIVSGKMFSEGQLEESHSFHIEPSGDLVNRSGRSTFDLSTSDKKTEKTPVYMNF 904
Cdd:pfam15818  795 DLFLLVNVNERQHTLLNNTEKTESLNDIVSGKIYSEGQLEESHSFHIKPSGDLVNRSGRSAFDLSTSDKKTEKTPVYLNF 874
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    905 SDPGPWSKVNHIESQTASSSTPCISLLLKERPLDPSENKKIISMALCKNIGVDDVGKDIGPDTTSINRVADTLNNWSIHP 984
Cdd:pfam15818  875 LDPSPWSKVNQTEGQTVSTSTSSIPLLLKEKPIGPSENTKIISVTLCKNVGVDDVRKDIGPDTTSISRVADTLNNSSIHP 954
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    985 DPKGEPSEEKNAMAKTFYDSSFPTEHVKTKPLISTPLQSHLQAIKTT------KNTSGDDDWQSLITNQLNKSENLLSLE 1058
Cdd:pfam15818  955 DPKGEPSEERNATAKTFYDSSFPTEHVKTEPLKSTVLQSHFQTVKIKdspdllKSSPGEDDWQSLITNQITEIEKLLSLE 1034
                         1050
                   ....*....|....
gi 83715968   1059 NDNQPKKRKAEETL 1072
Cdd:pfam15818 1035 NDNQPKKRKAEEML 1048
 
Name Accession Description Interval E-value
CCDC73 pfam15818
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ...
26-1072 0e+00

Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.


Pssm-ID: 464893 [Multi-domain]  Cd Length: 1048  Bit Score: 1568.40  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     26 QLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEK 105
Cdd:pfam15818    1 QLLDFKTSLLEALEELRMRREAETQYEEQIGKIIVETQELKWQKETLQNQKETLAKQHKEAMAVFKKQLQMKMCALEEEK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    106 GKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKL 185
Cdd:pfam15818   81 GKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKLQLHLLAKEDHHKQLNEIEKYYATITGQFGLVKENHGKL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    186 EQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEK 265
Cdd:pfam15818  161 EQNVQEAIQLNKRLSALNKKQESEICSLKKELKKVTSDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNKK 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    266 INEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALG 345
Cdd:pfam15818  241 INEEITHIQEEKQDIIISFQHMQQLLQQQTQANTEMEAELKALKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALG 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    346 TWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQE 425
Cdd:pfam15818  321 TWKKHVEELNGEINEIKNELSSLKETHIKLQEHYNKLCNQKKFEEDKKFQNVPEVNNENSEMSTEKSENLIIQKYNSEQE 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    426 IREENMENFCSDTEYReKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNV 505
Cdd:pfam15818  401 IREENTKSFCSDTEYR-ETEKKKGPPVEEIIIEDLQVLEKSFKNEIDTSVPQDKNQSEISLSKTLCTDKDLISQGQTLNV 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    506 TDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILNETAH 585
Cdd:pfam15818  480 TDFRKSVTTEIKDKLCLEKDNGCSEFKSPNNLFLVADQSIETEKIHLESTEGLGLHHADIHLETESNRSSFNGTLNEMAH 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    586 NTYHnnNKDVSENEPFK-QFRLLPGTREHALEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKq 664
Cdd:pfam15818  560 NTNH--NKDVSENEPFKqQFRLLLCTQENATEKRITNSDQTKAGLDSSLDVKKNPVQCQKYSLQDSSNVSLDDKQCKIE- 636
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    665 iQLLTKKSECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSKLLLKNSDKNVHSMSMLVKPNSSPG 744
Cdd:pfam15818  637 -QLLNKKSECSTLPLKQTSSFQQLCNDTSEKPGLTIPCDTVVSHPISPAAFSDNLKADLKNSDNNVNIMPMLVKPNSSPG 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    745 GKTMCKNMSDMQNSQFNNCLGYLENtNVNISHLHLNNENSHASQAKDVKTAVHMKTCTETEFSNKKNQIDENQVTEATKN 824
Cdd:pfam15818  716 KRTTRKNLDDMQSSQFKNCLGGLEN-GVTISHLQVNNENSHASQAKDLKTAVHPKTSTEIQFSSKESQIDENQITEATKN 794
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    825 DLFLFVSINERQHTLLNNTEKTESLNDIVSGKMFSEGQLEESHSFHIEPSGDLVNRSGRSTFDLSTSDKKTEKTPVYMNF 904
Cdd:pfam15818  795 DLFLLVNVNERQHTLLNNTEKTESLNDIVSGKIYSEGQLEESHSFHIKPSGDLVNRSGRSAFDLSTSDKKTEKTPVYLNF 874
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    905 SDPGPWSKVNHIESQTASSSTPCISLLLKERPLDPSENKKIISMALCKNIGVDDVGKDIGPDTTSINRVADTLNNWSIHP 984
Cdd:pfam15818  875 LDPSPWSKVNQTEGQTVSTSTSSIPLLLKEKPIGPSENTKIISVTLCKNVGVDDVRKDIGPDTTSISRVADTLNNSSIHP 954
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    985 DPKGEPSEEKNAMAKTFYDSSFPTEHVKTKPLISTPLQSHLQAIKTT------KNTSGDDDWQSLITNQLNKSENLLSLE 1058
Cdd:pfam15818  955 DPKGEPSEERNATAKTFYDSSFPTEHVKTEPLKSTVLQSHFQTVKIKdspdllKSSPGEDDWQSLITNQITEIEKLLSLE 1034
                         1050
                   ....*....|....
gi 83715968   1059 NDNQPKKRKAEETL 1072
Cdd:pfam15818 1035 NDNQPKKRKAEEML 1048
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
35-370 1.92e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 65.34  E-value: 1.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   35 LEALEelRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVfKKQLQMKMCALEEEKGKYQLATEI 114
Cdd:COG1196  202 LEPLE--RQAEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAE-LEELEAELAELEAELEELRLELEE 278
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  115 KEKEIEGLKETLkalqvskYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEkyyatitgqfglvkENHEKLEQNVREAIQ 194
Cdd:COG1196  279 LELELEEAQAEE-------YELLAELARLEQDIARLEERRRELEERLEELE--------------EELAELEEELEELEE 337
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  195 SNKRLSALNKKQEAEICSLKKELKKAASDLIKSkvtcqykmgeeninLTIKEQKFQELQERLNMELELNEKINEEITHIQ 274
Cdd:COG1196  338 ELEELEEELEEAEEELEEAEAELAEAEEALLEA--------------EAELAEAEEELEELAEELLEALRAAAELAAQLE 403
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  275 EEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGtWKRHAEEL 354
Cdd:COG1196  404 ELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAAL-LEAALAEL 482
                        330
                 ....*....|....*.
gi 83715968  355 NGEINKIKNELSSLKE 370
Cdd:COG1196  483 LEELAEAAARLLLLLE 498
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
52-376 2.33e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.62  E-value: 2.33e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     52 EEQIGKIIVETQELKWQKETLQNQKETLAE-----------------QHKEAMAVFKKQLQMKMCALEEEKGKYQLATEI 114
Cdd:TIGR02169  183 EENIERLDLIIDEKRQQLERLRREREKAERyqallkekreyegyellKEKEALERQKEAIERQLASLEEELEKLTEEISE 262
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    115 KEKEIEGLKETLKAL--QVSKYS------LQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLE 186
Cdd:TIGR02169  263 LEKRLEEIEQLLEELnkKIKDLGeeeqlrVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELE 342
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    187 QNVREaiqSNKRLSALnkkqEAEICSLKKELKKAASDLikskvtcqykmGEENINLTIKEQKFQELQERLNMeleLNEKI 266
Cdd:TIGR02169  343 REIEE---ERKRRDKL----TEEYAELKEELEDLRAEL-----------EEVDKEFAETRDELKDYREKLEK---LKREI 401
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    267 NEeithiqeekqdIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQneheKALGT 346
Cdd:TIGR02169  402 NE-----------LKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLA----ADLSK 466
                          330       340       350
                   ....*....|....*....|....*....|
gi 83715968    347 WKRHAEELNGEINKIKNELSSLKETHIKLQ 376
Cdd:TIGR02169  467 YEQELYDLKEEYDRVEKELSKLQRELAEAE 496
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
24-419 1.75e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.92  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    24 SIQLLDFKTSLLEALEELRMRREaeihyEEQIGKIIVETQELKWQKETLQNQKETLaEQHKEAMAVFKKQLQMKMCALEE 103
Cdd:PRK03918  360 RHELYEEAKAKKEELERLKKRLT-----GLTPEKLEKELEELEKAKEEIEEEISKI-TARIGELKKEIKELKKAIEELKK 433
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   104 EKGK-------------------YQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKedyhkQLSEI 164
Cdd:PRK03918  434 AKGKcpvcgrelteehrkelleeYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAE-----QLKEL 508
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   165 EKyyatitgqfGLVKENHEKLEQNVREAIQSNKRLSALnkkqEAEICSLKKELKKAAsDLIKSKVTCQYKMGE-----EN 239
Cdd:PRK03918  509 EE---------KLKKYNLEELEKKAEEYEKLKEKLIKL----KGEIKSLKKELEKLE-ELKKKLAELEKKLDEleeelAE 574
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   240 INLTIKEQKFQELQErLNMELELNEKINEEITHIQEEKQDIiisfqhmQQLLRQQIQANTEMEAELKVLKENNQTLER-D 318
Cdd:PRK03918  575 LLKELEELGFESVEE-LEERLKELEPFYNEYLELKDAEKEL-------EREEKELKKLEEELDKAFEELAETEKRLEElR 646
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   319 NELQREKVKENEEKFLNLQNEH-----------------EKALGTWKRHAEELN---GEINKIKNELSSLKETHIKLQEH 378
Cdd:PRK03918  647 KELEELEKKYSEEEYEELREEYlelsrelaglraeleelEKRREEIKKTLEKLKeelEEREKAKKELEKLEKALERVEEL 726
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 83715968   379 YNKLCNQKTFEEDKKFQNVPEVNNE-NSEMSTEKSENTIIQK 419
Cdd:PRK03918  727 REKVKKYKALLKERALSKVGEIASEiFEELTEGKYSGVRVKA 768
 
Name Accession Description Interval E-value
CCDC73 pfam15818
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ...
26-1072 0e+00

Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.


Pssm-ID: 464893 [Multi-domain]  Cd Length: 1048  Bit Score: 1568.40  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     26 QLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEK 105
Cdd:pfam15818    1 QLLDFKTSLLEALEELRMRREAETQYEEQIGKIIVETQELKWQKETLQNQKETLAKQHKEAMAVFKKQLQMKMCALEEEK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    106 GKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKL 185
Cdd:pfam15818   81 GKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKLQLHLLAKEDHHKQLNEIEKYYATITGQFGLVKENHGKL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    186 EQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEK 265
Cdd:pfam15818  161 EQNVQEAIQLNKRLSALNKKQESEICSLKKELKKVTSDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNKK 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    266 INEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALG 345
Cdd:pfam15818  241 INEEITHIQEEKQDIIISFQHMQQLLQQQTQANTEMEAELKALKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALG 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    346 TWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQE 425
Cdd:pfam15818  321 TWKKHVEELNGEINEIKNELSSLKETHIKLQEHYNKLCNQKKFEEDKKFQNVPEVNNENSEMSTEKSENLIIQKYNSEQE 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    426 IREENMENFCSDTEYReKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNV 505
Cdd:pfam15818  401 IREENTKSFCSDTEYR-ETEKKKGPPVEEIIIEDLQVLEKSFKNEIDTSVPQDKNQSEISLSKTLCTDKDLISQGQTLNV 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    506 TDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILNETAH 585
Cdd:pfam15818  480 TDFRKSVTTEIKDKLCLEKDNGCSEFKSPNNLFLVADQSIETEKIHLESTEGLGLHHADIHLETESNRSSFNGTLNEMAH 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    586 NTYHnnNKDVSENEPFK-QFRLLPGTREHALEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKq 664
Cdd:pfam15818  560 NTNH--NKDVSENEPFKqQFRLLLCTQENATEKRITNSDQTKAGLDSSLDVKKNPVQCQKYSLQDSSNVSLDDKQCKIE- 636
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    665 iQLLTKKSECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSKLLLKNSDKNVHSMSMLVKPNSSPG 744
Cdd:pfam15818  637 -QLLNKKSECSTLPLKQTSSFQQLCNDTSEKPGLTIPCDTVVSHPISPAAFSDNLKADLKNSDNNVNIMPMLVKPNSSPG 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    745 GKTMCKNMSDMQNSQFNNCLGYLENtNVNISHLHLNNENSHASQAKDVKTAVHMKTCTETEFSNKKNQIDENQVTEATKN 824
Cdd:pfam15818  716 KRTTRKNLDDMQSSQFKNCLGGLEN-GVTISHLQVNNENSHASQAKDLKTAVHPKTSTEIQFSSKESQIDENQITEATKN 794
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    825 DLFLFVSINERQHTLLNNTEKTESLNDIVSGKMFSEGQLEESHSFHIEPSGDLVNRSGRSTFDLSTSDKKTEKTPVYMNF 904
Cdd:pfam15818  795 DLFLLVNVNERQHTLLNNTEKTESLNDIVSGKIYSEGQLEESHSFHIKPSGDLVNRSGRSAFDLSTSDKKTEKTPVYLNF 874
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    905 SDPGPWSKVNHIESQTASSSTPCISLLLKERPLDPSENKKIISMALCKNIGVDDVGKDIGPDTTSINRVADTLNNWSIHP 984
Cdd:pfam15818  875 LDPSPWSKVNQTEGQTVSTSTSSIPLLLKEKPIGPSENTKIISVTLCKNVGVDDVRKDIGPDTTSISRVADTLNNSSIHP 954
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    985 DPKGEPSEEKNAMAKTFYDSSFPTEHVKTKPLISTPLQSHLQAIKTT------KNTSGDDDWQSLITNQLNKSENLLSLE 1058
Cdd:pfam15818  955 DPKGEPSEERNATAKTFYDSSFPTEHVKTEPLKSTVLQSHFQTVKIKdspdllKSSPGEDDWQSLITNQITEIEKLLSLE 1034
                         1050
                   ....*....|....
gi 83715968   1059 NDNQPKKRKAEETL 1072
Cdd:pfam15818 1035 NDNQPKKRKAEEML 1048
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
35-370 1.92e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 65.34  E-value: 1.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   35 LEALEelRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVfKKQLQMKMCALEEEKGKYQLATEI 114
Cdd:COG1196  202 LEPLE--RQAEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAE-LEELEAELAELEAELEELRLELEE 278
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  115 KEKEIEGLKETLkalqvskYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEkyyatitgqfglvkENHEKLEQNVREAIQ 194
Cdd:COG1196  279 LELELEEAQAEE-------YELLAELARLEQDIARLEERRRELEERLEELE--------------EELAELEEELEELEE 337
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  195 SNKRLSALNKKQEAEICSLKKELKKAASDLIKSkvtcqykmgeeninLTIKEQKFQELQERLNMELELNEKINEEITHIQ 274
Cdd:COG1196  338 ELEELEEELEEAEEELEEAEAELAEAEEALLEA--------------EAELAEAEEELEELAEELLEALRAAAELAAQLE 403
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  275 EEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGtWKRHAEEL 354
Cdd:COG1196  404 ELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAAL-LEAALAEL 482
                        330
                 ....*....|....*.
gi 83715968  355 NGEINKIKNELSSLKE 370
Cdd:COG1196  483 LEELAEAAARLLLLLE 498
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
52-376 2.33e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.62  E-value: 2.33e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     52 EEQIGKIIVETQELKWQKETLQNQKETLAE-----------------QHKEAMAVFKKQLQMKMCALEEEKGKYQLATEI 114
Cdd:TIGR02169  183 EENIERLDLIIDEKRQQLERLRREREKAERyqallkekreyegyellKEKEALERQKEAIERQLASLEEELEKLTEEISE 262
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    115 KEKEIEGLKETLKAL--QVSKYS------LQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLE 186
Cdd:TIGR02169  263 LEKRLEEIEQLLEELnkKIKDLGeeeqlrVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELE 342
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    187 QNVREaiqSNKRLSALnkkqEAEICSLKKELKKAASDLikskvtcqykmGEENINLTIKEQKFQELQERLNMeleLNEKI 266
Cdd:TIGR02169  343 REIEE---ERKRRDKL----TEEYAELKEELEDLRAEL-----------EEVDKEFAETRDELKDYREKLEK---LKREI 401
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    267 NEeithiqeekqdIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQneheKALGT 346
Cdd:TIGR02169  402 NE-----------LKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLA----ADLSK 466
                          330       340       350
                   ....*....|....*....|....*....|
gi 83715968    347 WKRHAEELNGEINKIKNELSSLKETHIKLQ 376
Cdd:TIGR02169  467 YEQELYDLKEEYDRVEKELSKLQRELAEAE 496
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
117-370 8.32e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.01  E-value: 8.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  117 KEIEGLKETLKALQVSKYSLQKKVSEMEQKvqlhllaKEDYHKQLSEIEKYYATITgqfglvkenhEKLEQNVREAIQSN 196
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKE-------EKALLKQLAALERRIAALA----------RRIRALEQELAALE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  197 KRLSALNKKQEAeicsLKKELKKAASDLIKSKVTcQYKMGEEN-INLTIKEQKFQELQERLNMELELNEKINEEITHIQE 275
Cdd:COG4942   83 AELAELEKEIAE----LRAELEAQKEELAELLRA-LYRLGRQPpLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  276 EKQDIiisfqhmQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKflnlQNEHEKALGTWKRHAEELN 355
Cdd:COG4942  158 DLAEL-------AALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKE----LAELAAELAELQQEAEELE 226
                        250
                 ....*....|....*
gi 83715968  356 GEINKIKNELSSLKE 370
Cdd:COG4942  227 ALIARLEAEAAAAAE 241
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
101-432 1.29e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 59.30  E-value: 1.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    101 LEEEKG--KYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEdYHKQLSEIEKYYATitgqfGLV 178
Cdd:TIGR02168  161 FEEAAGisKYKERRKETERKLERTRENLDRLEDILNELERQLKSLERQAEKAERYKE-LKAELRELELALLV-----LRL 234
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    179 KENHEKLEQNVREAIQSNKRLSALNKKQEAeicslkKELKKAASDLIKSKVtcqykmgeeninltikEQKFQELQERLNM 258
Cdd:TIGR02168  235 EELREELEELQEELKEAEEELEELTAELQE------LEEKLEELRLEVSEL----------------EEEIEELQKELYA 292
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    259 ELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQN 338
Cdd:TIGR02168  293 LANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELES 372
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    339 ---EHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDK----KFQNVPEVNNENSEM--ST 409
Cdd:TIGR02168  373 rleELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKleeaELKELQAELEELEEEleEL 452
                          330       340
                   ....*....|....*....|...
gi 83715968    410 EKSENTIIQKYNTEQEIREENME 432
Cdd:TIGR02168  453 QEELERLEEALEELREELEEAEQ 475
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
24-419 1.75e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.92  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    24 SIQLLDFKTSLLEALEELRMRREaeihyEEQIGKIIVETQELKWQKETLQNQKETLaEQHKEAMAVFKKQLQMKMCALEE 103
Cdd:PRK03918  360 RHELYEEAKAKKEELERLKKRLT-----GLTPEKLEKELEELEKAKEEIEEEISKI-TARIGELKKEIKELKKAIEELKK 433
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   104 EKGK-------------------YQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKedyhkQLSEI 164
Cdd:PRK03918  434 AKGKcpvcgrelteehrkelleeYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAE-----QLKEL 508
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   165 EKyyatitgqfGLVKENHEKLEQNVREAIQSNKRLSALnkkqEAEICSLKKELKKAAsDLIKSKVTCQYKMGE-----EN 239
Cdd:PRK03918  509 EE---------KLKKYNLEELEKKAEEYEKLKEKLIKL----KGEIKSLKKELEKLE-ELKKKLAELEKKLDEleeelAE 574
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   240 INLTIKEQKFQELQErLNMELELNEKINEEITHIQEEKQDIiisfqhmQQLLRQQIQANTEMEAELKVLKENNQTLER-D 318
Cdd:PRK03918  575 LLKELEELGFESVEE-LEERLKELEPFYNEYLELKDAEKEL-------EREEKELKKLEEELDKAFEELAETEKRLEElR 646
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   319 NELQREKVKENEEKFLNLQNEH-----------------EKALGTWKRHAEELN---GEINKIKNELSSLKETHIKLQEH 378
Cdd:PRK03918  647 KELEELEKKYSEEEYEELREEYlelsrelaglraeleelEKRREEIKKTLEKLKeelEEREKAKKELEKLEKALERVEEL 726
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 83715968   379 YNKLCNQKTFEEDKKFQNVPEVNNE-NSEMSTEKSENTIIQK 419
Cdd:PRK03918  727 REKVKKYKALLKERALSKVGEIASEiFEELTEGKYSGVRVKA 768
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
137-382 3.67e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.76  E-value: 3.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    137 QKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKE 216
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKE 755
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    217 LKkaasDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQH----MQQLLR 292
Cdd:TIGR02168  756 LT----ELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANlrerLESLER 831
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    293 QQIQANTEMEAELKVLKENNQTLER------DNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELS 366
Cdd:TIGR02168  832 RIAATERRLEDLEEQIEELSEDIESlaaeieELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRS 911
                          250
                   ....*....|....*.
gi 83715968    367 SLKETHIKLQEHYNKL 382
Cdd:TIGR02168  912 ELRRELEELREKLAQL 927
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
63-408 8.64e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 56.60  E-value: 8.64e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     63 QELKWQKETLQ-----NQKETLAEQhKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQ 137
Cdd:TIGR02168  216 KELKAELRELElallvLRLEELREE-LEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALA 294
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    138 KKVSEMEQKVQLHLLAKEDYHKQLSEIEkyyatitgqfglvkenhEKLEQNVREAIQSNKRLSALNKKQE---AEICSLK 214
Cdd:TIGR02168  295 NEISRLEQQKQILRERLANLERQLEELE-----------------AQLEELESKLDELAEELAELEEKLEelkEELESLE 357
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    215 KELKKAASDLIKSKVTcqykmgeeninLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIiisfQHMQQLLRQQ 294
Cdd:TIGR02168  358 AELEELEAELEELESR-----------LEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERL----EDRRERLQQE 422
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    295 IQANtEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLqnehekalgtwkrhaEELNGEINKIKNELSSLKETHIK 374
Cdd:TIGR02168  423 IEEL-LKKLEEAELKELQAELEELEEELEELQEELERLEEAL---------------EELREELEEAEQALDAAERELAQ 486
                          330       340       350
                   ....*....|....*....|....*....|....
gi 83715968    375 LQEHYNKLCNQKTfEEDKKFQNVPEVNNENSEMS 408
Cdd:TIGR02168  487 LQARLDSLERLQE-NLEGFSEGVKALLKNQSGLS 519
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
8-388 1.39e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.83  E-value: 1.39e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968      8 ESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIG----KIIVETQELKWQKETLQNQKETLAEQH 83
Cdd:TIGR02168  681 ELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISalrkDLARLEAEVEQLEERIAQLSKELTELE 760
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     84 KEAMAVFKK--QLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQL 161
Cdd:TIGR02168  761 AEIEELEERleEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRL 840
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    162 SEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLikskvtcqykmGEENIN 241
Cdd:TIGR02168  841 EDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEEL-----------RELESK 909
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    242 LTIKEQKFQELQERLN-MELELnEKINEEITHIQEE-KQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDN 319
Cdd:TIGR02168  910 RSELRRELEELREKLAqLELRL-EGLEVRIDNLQERlSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGPVN 988
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 83715968    320 ELQREKVKENEEKFLNLQNEHE---KALGTWKRHAEELNGEInkikneLSSLKETHIKLQEHYNKLCnQKTF 388
Cdd:TIGR02168  989 LAAIEEYEELKERYDFLTAQKEdltEAKETLEEAIEEIDREA------RERFKDTFDQVNENFQRVF-PKLF 1053
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
34-429 1.93e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 55.46  E-value: 1.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    34 LLEALEELRMRREA---EIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQmKMCALEEEKGKYQL 110
Cdd:PRK03918  167 LGEVIKEIKRRIERlekFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVK-ELEELKEEIEELEK 245
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   111 ATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKV----QLHLLAKE---------DYHKQLSEIEKYYATITGQFGL 177
Cdd:PRK03918  246 ELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVkelkELKEKAEEyiklsefyeEYLDELREIEKRLSRLEEEING 325
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   178 VKENHEKLEQNVREAIQSNKRLSALNKKQEA---------EICSLKKELKKaasdlIKSKVTCqYKMGEENINLTIKEQK 248
Cdd:PRK03918  326 IEERIKELEEKEERLEELKKKLKELEKRLEEleerhelyeEAKAKKEELER-----LKKRLTG-LTPEKLEKELEELEKA 399
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   249 FQELQERLNmelELNEKINEEITHIQEEKQDII---------------ISFQHMQQLLRQQIQANTEMEAELKVLKENNQ 313
Cdd:PRK03918  400 KEEIEEEIS---KITARIGELKKEIKELKKAIEelkkakgkcpvcgreLTEEHRKELLEEYTAELKRIEKELKEIEEKER 476
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   314 TLERdNELQREKVKENEEKFLNLQN------EHEKALGTW--------KRHAEELNGEINKIKNELSSLKETHIKLQEHY 379
Cdd:PRK03918  477 KLRK-ELRELEKVLKKESELIKLKElaeqlkELEEKLKKYnleelekkAEEYEKLKEKLIKLKGEIKSLKKELEKLEELK 555
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 83715968   380 NKLC----NQKTFEEDKK----------FQNVPEVNNENSEMstEKSENTIIQKYNTEQEIREE 429
Cdd:PRK03918  556 KKLAelekKLDELEEELAellkeleelgFESVEELEERLKEL--EPFYNEYLELKDAEKELERE 617
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
173-433 3.77e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 54.30  E-value: 3.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   173 GQFGLVKENHEKLEQNVREAIQ------SNKRLSALNKKQEAEICSLKKELKKAAS--DLIKSKVTCQYKMGEENINLTI 244
Cdd:PRK03918  135 GEIDAILESDESREKVVRQILGlddyenAYKNLGEVIKEIKRRIERLEKFIKRTENieELIKEKEKELEEVLREINEISS 214
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   245 KEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLE--RDNELQ 322
Cdd:PRK03918  215 ELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKelKEKAEE 294
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   323 REKVKENEEKFLNLQNEHEKALGTW-----------------KRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQ 385
Cdd:PRK03918  295 YIKLSEFYEEYLDELREIEKRLSRLeeeingieerikeleekEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEEL 374
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 83715968   386 KTFEEDKKFQNVPEVNNENSEMSTEKSE-----NTIIQKYNTEQEIREENMEN 433
Cdd:PRK03918  375 ERLKKRLTGLTPEKLEKELEELEKAKEEieeeiSKITARIGELKKEIKELKKA 427
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
32-432 4.32e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 54.28  E-value: 4.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    32 TSLLEALEELRMRREAEIHYEEQIGKiivETQELKWQKETLQNQKETLAEQ------HKEAMAVFKKQLQMKMCALEEEK 105
Cdd:PRK02224  254 ETLEAEIEDLRETIAETEREREELAE---EVRDLRERLEELEEERDDLLAEaglddaDAEAVEARREELEDRDEELRDRL 330
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   106 GKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKL 185
Cdd:PRK02224  331 EECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNA 410
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   186 EqNVREAIQSNK-RLSALNKKQEAEICSLKKELKKAASDLIKSKV-TCQYKMGEENINLTI--KEQKFQELQERL-NMEL 260
Cdd:PRK02224  411 E-DFLEELREERdELREREAELEATLRTARERVEEAEALLEAGKCpECGQPVEGSPHVETIeeDRERVEELEAELeDLEE 489
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   261 E---LNEKINE---------EITHIQEEKQDIiisfqhmQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKE 328
Cdd:PRK02224  490 EveeVEERLERaedlveaedRIERLEERREDL-------EELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAE 562
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   329 NEEkflnlqnEHEKALGTwkrhAEELNGEINKIKNELSSLKETHIKLQEHYNklCNQKTFEEDKKFQNVPEVNNENSEMS 408
Cdd:PRK02224  563 AEE-------EAEEAREE----VAELNSKLAELKERIESLERIRTLLAAIAD--AEDEIERLREKREALAELNDERRERL 629
                         410       420
                  ....*....|....*....|....
gi 83715968   409 TEKSEntiiQKYNTEQEIREENME 432
Cdd:PRK02224  630 AEKRE----RKRELEAEFDEARIE 649
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
34-324 4.84e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.17  E-value: 4.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   34 LLEALEELRMRREAEihyEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAvfkkqlqmkmcALEEEKGKYQLAT- 112
Cdd:COG1196  230 LLLKLRELEAELEEL---EAELEELEAELEELEAELAELEAELEELRLELEELEL-----------ELEEAQAEEYELLa 295
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  113 --EIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVR 190
Cdd:COG1196  296 elARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELA 375
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  191 EAIQSNKRLSALNKKQEAEICSLKKELKKAASDLikskvtcQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEI 270
Cdd:COG1196  376 EAEEELEELAEELLEALRAAAELAAQLEELEEAE-------EALLERLERLEEELEELEEALAELEEEEEEEEEALEEAA 448
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 83715968  271 THIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQRE 324
Cdd:COG1196  449 EEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEAD 502
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
30-382 7.94e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 53.53  E-value: 7.94e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     30 FKTSLLEALEELR-----MRREAEI------HYEEQIGKIIVETQELKWQKETLQNQKETLAEQHkEAMAVFKKQLQMKM 98
Cdd:TIGR02169  668 FSRSEPAELQRLRerlegLKRELSSlqselrRIENRLDELSQELSDASRKIGEIEKEIEQLEQEE-EKLKERLEELEEDL 746
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     99 CALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEME-QKVQLHLLAKEDYHkqlSEIEKYYATITGQFGL 177
Cdd:TIGR02169  747 SSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRiPEIQAELSKLEEEV---SRIEARLREIEQKLNR 823
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    178 VKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTcQYKMGEENINLTIK----EQKFQELQ 253
Cdd:TIGR02169  824 LTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAA-LRDLESRLGDLKKErdelEAQLRELE 902
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    254 ERLNmelELNEKINEEITHIQEEKQDIIISFQHMQQLLR--QQIQANTEMEAELKVLKENNQTLERD-------NELQRE 324
Cdd:TIGR02169  903 RKIE---ELEAQIEKKRKRLSELKAKLEALEEELSEIEDpkGEDEEIPEEELSLEDVQAELQRVEEEiralepvNMLAIQ 979
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 83715968    325 KVKENEEKFLNLQNEHEKaLGTWKRHAEELNGEINKIKNElsSLKETHIKLQEHYNKL 382
Cdd:TIGR02169  980 EYEEVLKRLDELKEKRAK-LEEERKAILERIEEYEKKKRE--VFMEAFEAINENFNEI 1034
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
110-377 1.03e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.02  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  110 LATEIkEKEIEGLKEtlKALQVSKY-SLQKKvsEMEQKVQLHLLAKEDYHKQLSEIEkyyatitgqfglvkenhEKLEQN 188
Cdd:COG1196  194 ILGEL-ERQLEPLER--QAEKAERYrELKEE--LKELEAELLLLKLRELEAELEELE-----------------AELEEL 251
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  189 VREAIQSNKRLSALnkkqEAEICSLKKELKKAasdlikskvtcqykmgeeninltikEQKFQELQERLNMELELNEKINE 268
Cdd:COG1196  252 EAELEELEAELAEL----EAELEELRLELEEL-------------------------ELELEEAQAEEYELLAELARLEQ 302
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  269 EITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWK 348
Cdd:COG1196  303 DIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELE 382
                        250       260
                 ....*....|....*....|....*....
gi 83715968  349 RHAEELNGEINKIKNELSSLKETHIKLQE 377
Cdd:COG1196  383 ELAEELLEALRAAAELAAQLEELEEAEEA 411
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
102-427 1.66e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 52.38  E-value: 1.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    102 EEEKGKYQLATEIKEKEIEGL-KETLKALqvsKY-SLQKKVSEMEQKvqLHLLAKEDYHKQLSEIEKYYATITGQfglVK 179
Cdd:TIGR02169  183 EENIERLDLIIDEKRQQLERLrREREKAE---RYqALLKEKREYEGY--ELLKEKEALERQKEAIERQLASLEEE---LE 254
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    180 ENHEKLEQNVREAIQSNKRLSALNKKQEA----EICSLKKELKKAASDLIKSKVtcqykmgeeniNLTIKEQKFQELQER 255
Cdd:TIGR02169  255 KLTEEISELEKRLEEIEQLLEELNKKIKDlgeeEQLRVKEKIGELEAEIASLER-----------SIAEKERELEDAEER 323
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    256 LNMELELNEKINEEITHIQEEKQDiiisfqhmQQLLRQQIQAntemeaELKVLKENNQTLERDNElqrekvkeneekfln 335
Cdd:TIGR02169  324 LAKLEAEIDKLLAEIEELEREIEE--------ERKRRDKLTE------EYAELKEELEDLRAELE--------------- 374
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    336 lqnEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTF---------EEDKKFQNVPEVNNENSE 406
Cdd:TIGR02169  375 ---EVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADlnaaiagieAKINELEEEKEDKALEIK 451
                          330       340
                   ....*....|....*....|.
gi 83715968    407 MSTEKSENTIIQKYNTEQEIR 427
Cdd:TIGR02169  452 KQEWKLEQLAADLSKYEQELY 472
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
26-224 2.37e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 51.86  E-value: 2.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   26 QLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQmkmcALEEEK 105
Cdd:COG1196  289 EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEA----ELAEAE 364
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  106 GKYQLATEIKEKEIEGLKETLKALQvskySLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKL 185
Cdd:COG1196  365 EALLEAEAELAEAEEELEELAEELL----EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEE 440
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 83715968  186 EQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDL 224
Cdd:COG1196  441 EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAAL 479
PTZ00121 PTZ00121
MAEBL; Provisional
31-435 3.00e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 51.68  E-value: 3.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    31 KTSLLEALEELRMRREAEIhyeEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQL 110
Cdd:PTZ00121 1576 KNMALRKAEEAKKAEEARI---EEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEEL 1652
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   111 ATEIKEKEIEGLKETLKALQVSKYSLQ-KKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYAtitgqfglvkENHEKLEQNV 189
Cdd:PTZ00121 1653 KKAEEENKIKAAEEAKKAEEDKKKAEEaKKAEEDEKKAAEALKKEAEEAKKAEELKKKEA----------EEKKKAEELK 1722
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   190 REAIQSNKRLSALNKKQEAEicslKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQErlnmelELNEKINEE 269
Cdd:PTZ00121 1723 KAEEENKIKAEEAKKEAEED----KKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE------ELDEEDEKR 1792
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   270 ITHIQEEKQDIIISFQHMQQLLRQ-QIQANTEMEAELKVLKENNQTlerdNELQREKVKENEEKFLNLQNEHEKALGTwk 348
Cdd:PTZ00121 1793 RMEVDKKIKDIFDNFANIIEGGKEgNLVINDSKEMEDSAIKEVADS----KNMQLEEADAFEKHKFNKNNENGEDGNK-- 1866
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   349 rhaeelNGEINKIKNELSSLKETHIKLQEhyNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIRE 428
Cdd:PTZ00121 1867 ------EADFNKEKDLKEDDEEEIEEADE--IEKIDKDDIEREIPNNNMAGKNNDIIDDKLDKDEYIKRDAEETREEIIK 1938

                  ....*..
gi 83715968   429 ENMENFC 435
Cdd:PTZ00121 1939 ISKKDMC 1945
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
29-342 3.81e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 51.13  E-value: 3.81e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     29 DFKTSLLEALEELRMRREAEIHYEeqigKIIVETQELK---WQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEK 105
Cdd:pfam02463  153 ERRLEIEEEAAGSRLKRKKKEALK----KLIEETENLAeliIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLY 228
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    106 GKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQ----LHLLAKEDYHKQLSEIEKYYATITGQFGLVKEN 181
Cdd:pfam02463  229 LDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLkenkEEEKEKKLQEEELKLLAKEEEELKSELLKLERR 308
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    182 HEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQ---KFQELQERLNM 258
Cdd:pfam02463  309 KVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEEllaKKKLESERLSS 388
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    259 ELELNEKINEEITHIQEEKQDIIisfQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQN 338
Cdd:pfam02463  389 AAKLKEEELELKSEEEKEAQLLL---ELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDEL 465

                   ....
gi 83715968    339 EHEK 342
Cdd:pfam02463  466 ELKK 469
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
24-377 4.01e-06

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 51.27  E-value: 4.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     24 SIQLLDFKtSLLEALEELRMRREAEIHYEEqiGKIIVETQELKWQKETLQNQKETLAEQHKEAMAvfkkqlqmkmcalee 103
Cdd:pfam15921  209 SMSTMHFR-SLGSAISKILRELDTEISYLK--GRIFPVEDQLEALKSESQNKIELLLQQHQDRIE--------------- 270
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    104 ekgkyQLATEiKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHllaKEDYHKQLSEIEkyyATITgqfglvkenhe 183
Cdd:pfam15921  271 -----QLISE-HEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQ---NSMYMRQLSDLE---STVS----------- 327
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    184 KLEQNVREAiqsnKRLsalnkkQEAEICSLKKELKKAASDLIKSKvTCQYKMGEENINLTIKEQK----FQELQERLNME 259
Cdd:pfam15921  328 QLRSELREA----KRM------YEDKIEELEKQLVLANSELTEAR-TERDQFSQESGNLDDQLQKlladLHKREKELSLE 396
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    260 LELNEKINEE-------ITHIQEEKQDIIISFQHMQQLLRQ-QIQANTEMEAELKVLKENNQTLER----------DNEL 321
Cdd:pfam15921  397 KEQNKRLWDRdtgnsitIDHLRRELDDRNMEVQRLEALLKAmKSECQGQMERQMAAIQGKNESLEKvssltaqlesTKEM 476
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 83715968    322 QREKVKENEEKFLNLQNEHEK------ALGTWKRHAEELNGEINKIKNELSslkethIKLQE 377
Cdd:pfam15921  477 LRKVVEELTAKKMTLESSERTvsdltaSLQEKERAIEATNAEITKLRSRVD------LKLQE 532
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
61-438 4.14e-06

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 50.89  E-value: 4.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     61 ETQELKWQKETLQNQKETLAEQHKEAMAvfkkqlqmkmcalEEEKGKYQLATEIkEKEIEGLKETLKALQVskysLQKKV 140
Cdd:pfam05557    3 ELIESKARLSQLQNEKKQMELEHKRARI-------------ELEKKASALKRQL-DRESDRNQELQKRIRL----LEKRE 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    141 SEMEQKvqlhllakedYHKQLSEIEKYYATITGQFGLVKENHEKLEQnVREAIQS-NKRLSALN---KKQEAEICSLKKE 216
Cdd:pfam05557   65 AEAEEA----------LREQAELNRLKKKYLEALNKKLNEKESQLAD-AREVISClKNELSELRrqiQRAELELQSTNSE 133
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    217 LKKAasdlikskvtcQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQqiq 296
Cdd:pfam05557  134 LEEL-----------QERLDLLKAKASEAEQLRQNLEKQQSSLAEAEQRIKELEFEIQSQEQDSEIVKNSKSELARI--- 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    297 anTEMEAELKVLKENNQ---TLERDNELQREKVK------ENEEKF------LNLQNEH-EKALGTWKRHA--------- 351
Cdd:pfam05557  200 --PELEKELERLREHNKhlnENIENKLLLKEEVEdlkrklEREEKYreeaatLELEKEKlEQELQSWVKLAqdtglnlrs 277
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    352 -EELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQK----YNTEQEI 426
Cdd:pfam05557  278 pEDLSRRIEQLQQREIVLKEENSSLTSSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRrvllLTKERDG 357
                          410
                   ....*....|..
gi 83715968    427 REENMENFCSDT 438
Cdd:pfam05557  358 YRAILESYDKEL 369
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
169-377 1.50e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  169 ATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEA---EICSLKKELKKAASDLIKSKVtcQYKMGEENINLTIK 245
Cdd:COG4942   13 LAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKAllkQLAALERRIAALARRIRALEQ--ELAALEAELAELEK 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  246 EQkfQELQERLNmelELNEKINEEITHIQ--------------EEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKEN 311
Cdd:COG4942   91 EI--AELRAELE---AQKEELAELLRALYrlgrqpplalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAAL 165
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 83715968  312 NQTLERDNELQREKVKENEEKFLNLQNEHEKAlgtwKRHAEELNGEINKIKNELSSLKETHIKLQE 377
Cdd:COG4942  166 RAELEAERAELEALLAELEEERAALEALKAER----QKLLARLEKELAELAAELAELQQEAEELEA 227
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
213-393 3.08e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 48.23  E-value: 3.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  213 LKKELKKAASDLIKSK------VTCQYKMGEENIN-LTIKEQKFQELQERL---NMELELNEKINEEITHIQEEKQDIII 282
Cdd:COG4717   47 LLERLEKEADELFKPQgrkpelNLKELKELEEELKeAEEKEEEYAELQEELeelEEELEELEAELEELREELEKLEKLLQ 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  283 SFQHMQQL--LRQQIQANTE----MEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNG 356
Cdd:COG4717  127 LLPLYQELeaLEAELAELPErleeLEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQ 206
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 83715968  357 EINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKK 393
Cdd:COG4717  207 RLAELEEELEEAQEELEELEEELEQLENELEAAALEE 243
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
14-429 4.95e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 47.66  E-value: 4.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     14 TLQSSSETLfsIQLLDFKTSLLEALEELRMRREAEIHYE--EQIGKIIVETQElKWQKETLQNQKETLAEQHKEAMAvfK 91
Cdd:TIGR00618  383 TLQQQKTTL--TQKLQSLCKELDILQREQATIDTRTSAFrdLQGQLAHAKKQQ-ELQQRYAELCAAAITCTAQCEKL--E 457
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     92 KQLQMKMC-ALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYS---LQKKVSEMEQKVQL---------HLLAKEDYH 158
Cdd:TIGR00618  458 KIHLQESAqSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEpcpLCGSCIHPNPARQDidnpgpltrRMQRGEQTY 537
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    159 KQLSEIEKyyaTITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAaSDLIKSKVTCQYKMGEE 238
Cdd:TIGR00618  538 AQLETSEE---DVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRL-QDLTEKLSEAEDMLACE 613
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    239 NINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIiisfqhMQQLLRQQIQANTEMEAELKVLKENNQTLERD 318
Cdd:TIGR00618  614 QHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTL------TQERVREHALSIRVLPKELLASRQLALQKMQS 687
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    319 NELQREKVKENEEKFLNLQNEHEKALGTWKRHAEEL----NGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKF 394
Cdd:TIGR00618  688 EKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIenasSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNN 767
                          410       420       430
                   ....*....|....*....|....*....|....*
gi 83715968    395 QNVPevnnenSEMSTEKSENTIIQKYNTEQEIREE 429
Cdd:TIGR00618  768 EEVT------AALQTGAELSHLAAEIQFFNRLREE 796
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
16-429 7.01e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 47.04  E-value: 7.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     16 QSSSETLFSIQLLDFKTSLLEALEELR-MRREAEIHYEeqiGKIIVETQELKWQKETLQNQKETLAEQHKEAmavFKKQL 94
Cdd:pfam17380  224 QGMPHTLAPYEKMERRKESFNLAEDVTtMTPEYTVRYN---GQTMTENEFLNQLLHIVQHQKAVSERQQQEK---FEKME 297
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     95 QMKMCALEEEKGKyQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSeMEQKVQLHLLAKEDYHKQLSEIEKYyatitgQ 174
Cdd:pfam17380  298 QERLRQEKEEKAR-EVERRRKLEEAEKARQAEMDRQAAIYAEQERMA-MERERELERIRQEERKRELERIRQE------E 369
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    175 FGLVKENHEKLEQNVREAIQSNKRLsalnkkqeaeicslKKELKKAAsdlikskvtcQYKMGEENINLTIKEQKFQELQE 254
Cdd:pfam17380  370 IAMEISRMRELERLQMERQQKNERV--------------RQELEAAR----------KVKILEEERQRKIQQQKVEMEQI 425
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    255 RLNMElelnEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDN---ELQREKVKENEE 331
Cdd:pfam17380  426 RAEQE----EARQREVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRkraEEQRRKILEKEL 501
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    332 KflnlqnEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYnklcNQKTFEEDKKFQ-NVPEVNNENSEMSTE 410
Cdd:pfam17380  502 E------ERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERR----KQQEMEERRRIQeQMRKATEERSRLEAM 571
                          410
                   ....*....|....*....
gi 83715968    411 KSENTIIQKYNTEQEIREE 429
Cdd:pfam17380  572 EREREMMRQIVESEKARAE 590
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
116-343 8.95e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.55  E-value: 8.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  116 EKEIEGLKETLKALQ--VSKYSLQKKVSEMEQKVQLHLlakedyhKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAI 193
Cdd:COG3206  181 EEQLPELRKELEEAEaaLEEFRQKNGLVDLSEEAKLLL-------QQLSELESQLAEARAELAEAEARLAALRAQLGSGP 253
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  194 QSNKRLSalnkkQEAEICSLKKELKKAasdlikskvtcqykmgeeninltikEQKFQELQERLNME----LELNEKINEE 269
Cdd:COG3206  254 DALPELL-----QSPVIQQLRAQLAEL-------------------------EAELAELSARYTPNhpdvIALRAQIAAL 303
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 83715968  270 ITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKV-LKENNQTLERDNELQREkVKENEEKFLNLQNEHEKA 343
Cdd:COG3206  304 RAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEArLAELPELEAELRRLERE-VEVARELYESLLQRLEEA 377
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
81-393 9.35e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 46.50  E-value: 9.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     81 EQHKEAMA---VFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEdy 157
Cdd:TIGR00618  187 AKKKSLHGkaeLLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQ-- 264
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    158 hkQLSEIEKYyatiTGQFGLVKENHEKLEQNVREA--IQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKm 235
Cdd:TIGR00618  265 --LRARIEEL----RAQEAVLEETQERINRARKAAplAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQ- 337
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    236 geeninLTIKEQkfQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQlLRQQIQANTEMEAEL--KVLKENNQ 313
Cdd:TIGR00618  338 ------SSIEEQ--RRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHT-LQQQKTTLTQKLQSLckELDILQRE 408
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    314 TLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAeelngeinkIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKK 393
Cdd:TIGR00618  409 QATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAA---------ITCTAQCEKLEKIHLQESAQSLKEREQQLQTKE 479
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
70-433 2.18e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 45.81  E-value: 2.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     70 ETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGK-YQLATEIKEKEIEGLKEtlKALQVSK-YSLQKKVSEMEQKV 147
Cdd:TIGR01612 1250 EDLDEIKEKSPEIENEMGIEMDIKAEMETFNISHDDDKdHHIISKKHDENISDIRE--KSLKIIEdFSEESDINDIKKEL 1327
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    148 QLHLLakeDYHKQLSEIEKYYATITGQFGLVKENheKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLikS 227
Cdd:TIGR01612 1328 QKNLL---DAQKHNSDINLYLNEIANIYNILKLN--KIKKIIDEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDI--N 1400
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    228 KVTCQYKMgEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQllrqqiqANTEMEAELKV 307
Cdd:TIGR01612 1401 LEECKSKI-ESTLDDKDIDECIKKIKELKNHILSEESNIDTYFKNADENNENVLLLFKNIEM-------ADNKSQHILKI 1472
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    308 lKENNQTLERD---NELQREKVKENEEKFLNLQNEH--EKALGTWKRHAEELNGEINK-----IKNELSSLKETHIKLQE 377
Cdd:TIGR01612 1473 -KKDNATNDHDfniNELKEHIDKSKGCKDEADKNAKaiEKNKELFEQYKKDVTELLNKysalaIKNKFAKTKKDSEIIIK 1551
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 83715968    378 HYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMEN 433
Cdd:TIGR01612 1552 EIKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKNDKSNKAAIDIQLSLENFEN 1607
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
60-322 2.51e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 45.21  E-value: 2.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     60 VETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKK 139
Cdd:pfam12128  265 FGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAA 344
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    140 VSEMEQKVQlhllakedyhKQLSEIEKYYATITGQFGLVKENHEKLEQNVREaiQSNKRLSALNKKQEA--EICSLKKEL 217
Cdd:pfam12128  345 DQEQLPSWQ----------SELENLEERLKALTGKHQDVTAKYNRRRSKIKE--QNNRDIAGIKDKLAKirEARDRQLAV 412
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    218 KKAASDLIKSKVTCQYKMGEENIN-------LTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDiiISFQHMQQL 290
Cdd:pfam12128  413 AEDDLQALESELREQLEAGKLEFNeeeyrlkSRLGELKLRLNQATATPELLLQLENFDERIERAREEQE--AANAEVERL 490
                          250       260       270
                   ....*....|....*....|....*....|...
gi 83715968    291 LRQQIQANTEMEAELKVLKENNQTL-ERDNELQ 322
Cdd:pfam12128  491 QSELRQARKRRDQASEALRQASRRLeERQSALD 523
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
63-224 3.82e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 3.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   63 QELKWQKETLQNQKETLAEQHKEAMAVFK--KQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKV 140
Cdd:COG4942   27 AELEQLQQEIAELEKELAALKKEEKALLKqlAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEEL 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  141 SEMEQKVQLH--------LLAKED---------YHKQLS--------EIEKYYATITGQFGLVKENHEKLEQNVREAIQS 195
Cdd:COG4942  107 AELLRALYRLgrqpplalLLSPEDfldavrrlqYLKYLAparreqaeELRADLAELAALRAELEAERAELEALLAELEEE 186
                        170       180
                 ....*....|....*....|....*....
gi 83715968  196 NKRLSALNKKQEAEICSLKKELKKAASDL 224
Cdd:COG4942  187 RAALEALKAERQKLLARLEKELAELAAEL 215
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
34-382 3.86e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.37  E-value: 3.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   34 LLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFkkqlqmkmcALEEEKGKYQLATE 113
Cdd:COG4717  130 LYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQL---------SLATEEELQDLAEE 200
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  114 IKE--KEIEGLKETLKALQVSKYSLQKKVSEMEQKvqlhlLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVRE 191
Cdd:COG4717  201 LEElqQRLAELEEELEEAQEELEELEEELEQLENE-----LEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTI 275
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  192 A---------------IQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVtcQYKMGEENINLTIKEQKFQELQERL 256
Cdd:COG4717  276 AgvlflvlgllallflLLAREKASLGKEAEELQALPALEELEEEELEELLAAL--GLPPDLSPEELLELLDRIEELQELL 353
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  257 NMELELNEKIneEITHIQEEKqdiiisfqhmQQLLRqqiQANTEMEAELkvlkenNQTLERDNELQ--REKVKENEEKFL 334
Cdd:COG4717  354 REAEELEEEL--QLEELEQEI----------AALLA---EAGVEDEEEL------RAALEQAEEYQelKEELEELEEQLE 412
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 83715968  335 NLQNEHEKALGTWKRhaEELNGEINKIKNELSSLKETHIKLQEHYNKL 382
Cdd:COG4717  413 ELLGELEELLEALDE--EELEEELEELEEELEELEEELEELREELAEL 458
PTZ00121 PTZ00121
MAEBL; Provisional
31-518 4.79e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 4.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    31 KTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHK--------EAMAVFKKQLQMKMCALE 102
Cdd:PTZ00121 1523 KADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKnmalrkaeEAKKAEEARIEEVMKLYE 1602
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   103 EEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDyhkqlseiekyyatitgqfglvKENH 182
Cdd:PTZ00121 1603 EEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAE----------------------EENK 1660
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   183 EKLEQNVREAIQSNKRLSALNKKQE----AEICSLKKELKKAASDLIKSKVTCQYKMGEEninLTIKEQKFQELQERLNM 258
Cdd:PTZ00121 1661 IKAAEEAKKAEEDKKKAEEAKKAEEdekkAAEALKKEAEEAKKAEELKKKEAEEKKKAEE---LKKAEEENKIKAEEAKK 1737
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   259 ELELNEKINEEITHIQEEKQDIiisfqhmQQLLRQQIQANTEMEAELK-VLKENNQTLERDNELQREK-VKENEEKFLNL 336
Cdd:PTZ00121 1738 EAEEDKKKAEEAKKDEEEKKKI-------AHLKKEEEKKAEEIRKEKEaVIEEELDEEDEKRRMEVDKkIKDIFDNFANI 1810
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   337 QNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNN--ENSEMSTEKSEN 414
Cdd:PTZ00121 1811 IEGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLkeDDEEEIEEADEI 1890
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   415 TIIQKYNTEQEIREENMENFCSDTEYREKEekkegsfIEEIIIDDLQlfekSFKNEIDTVVSQDENQSEISlSKTLSLDK 494
Cdd:PTZ00121 1891 EKIDKDDIEREIPNNNMAGKNNDIIDDKLD-------KDEYIKRDAE----ETREEIIKISKKDMCINDFS-SKFCDYMK 1958
                         490       500
                  ....*....|....*....|....
gi 83715968   495 EVISQGQTSNVtdNRKSVTTEIKD 518
Cdd:PTZ00121 1959 DNISSGNCSDE--ERKELCCSISD 1980
HlpA COG2825
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...
181-281 4.93e-04

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442073 [Multi-domain]  Cd Length: 171  Bit Score: 42.13  E-value: 4.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  181 NHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTcqykMGEENIN-----LTIKEQKFQELQER 255
Cdd:COG2825   30 DVQRILQESPEGKAAQKKLEKEFKKRQAELQKLEKELQALQEKLQKEAAT----LSEEERQkkereLQKKQQELQRKQQE 105
                         90       100
                 ....*....|....*....|....*.
gi 83715968  256 LNMelELNEKINEEITHIQEEKQDII 281
Cdd:COG2825  106 AQQ--DLQKRQQELLQPILEKIQKAI 129
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
181-281 5.37e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 41.41  E-value: 5.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    181 NHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMel 260
Cdd:pfam03938    6 DMQKILEESPEGKAAQAQLEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQQKAQQ-- 83
                           90       100
                   ....*....|....*....|.
gi 83715968    261 ELNEKINEEITHIQEEKQDII 281
Cdd:pfam03938   84 ELQKKQQELLQPIQDKINKAI 104
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
179-337 8.43e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 43.28  E-value: 8.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   179 KENHEKLEQNVREAIQSnkrLSALNKKQEAEICSLKKELKKAasDLIKSKVtcqykmgeeninltikEQKFQELQERL-N 257
Cdd:PRK00409  508 KKLIGEDKEKLNELIAS---LEELERELEQKAEEAEALLKEA--EKLKEEL----------------EEKKEKLQEEEdK 566
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   258 MELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANtEMEAELKVLKENNQTLErdnelqrEKVKENEEKFLNLQ 337
Cdd:PRK00409  567 LLEEAEKEAQQAIKEAKKEADEIIKELRQLQKGGYASVKAH-ELIEARKRLNKANEKKE-------KKKKKQKEKQEELK 638
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
31-282 8.46e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.22  E-value: 8.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   31 KTSLLEALEEL---RMRREAEIHYEEQIGKIIVETQELKWQKETLQnqketlaeqhkeamavfkkqlqmkmcALEEEKGK 107
Cdd:COG4717   36 KSTLLAFIRAMlleRLEKEADELFKPQGRKPELNLKELKELEEELK--------------------------EAEEKEEE 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  108 YQLATEikekEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHllakeDYHKQLSEIEKYYATITGQFGLVKENHEKLEQ 187
Cdd:COG4717   90 YAELQE----ELEELEEELEELEAELEELREELEKLEKLLQLL-----PLYQELEALEAELAELPERLEELEERLEELRE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  188 NVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNmELELNEKIN 267
Cdd:COG4717  161 LEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELE-QLENELEAA 239
                        250
                 ....*....|....*
gi 83715968  268 EEITHIQEEKQDIII 282
Cdd:COG4717  240 ALEERLKEARLLLLI 254
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
100-680 8.85e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 43.50  E-value: 8.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    100 ALEEEKGKYQLATEIKEKEIEGLKET--LKALQVSKY--SLQKKVSEMEQKVQLhlLAKEDYHKQLSEIEKYYATITGQF 175
Cdd:TIGR01612  932 SIEKFHNKQNILKEILNKNIDTIKESnlIEKSYKDKFdnTLIDKINELDKAFKD--ASLNDYEAKNNELIKYFNDLKANL 1009
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    176 GLVKEN--------HEKLEQNVREAIQS-NKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKmgEENINLTike 246
Cdd:TIGR01612 1010 GKNKENmlyhqfdeKEKATNDIEQKIEDaNKNIPNIEIAIHTSIYNIIDEIEKEIGKNIELLNKEILE--EAEINIT--- 1084
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    247 qKFQELQERLNMeLELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEM----EAELKVLKENNQTLER--DNE 320
Cdd:TIGR01612 1085 -NFNEIKEKLKH-YNFDDFGKEENIKYADEINKIKDDIKNLDQKIDHHIKALEEIkkksENYIDEIKAQINDLEDvaDKA 1162
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    321 LQREKVKENEEKFLNLQNEHEKALGTWKRHAEELN--GEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNV- 397
Cdd:TIGR01612 1163 ISNDDPEEIEKKIENIVTKIDKKKNIYDEIKKLLNeiAEIEKDKTSLEEVKGINLSYGKNLGKLFLEKIDEEKKKSEHMi 1242
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    398 -----------------PEVNNE-------NSEMSTEKSENTIIQKYNTEQEIREENMenfcsdTEYREKEEKKEGSFIE 453
Cdd:TIGR01612 1243 kameayiedldeikeksPEIENEmgiemdiKAEMETFNISHDDDKDHHIISKKHDENI------SDIREKSLKIIEDFSE 1316
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    454 EIIIDDLqlfeksfKNEIDTVVSQDE-NQSEIS--LSKTLSLdKEVISQGQTSNVTDNRKSVTTEIKD---KICLEKDNG 527
Cdd:TIGR01612 1317 ESDINDI-------KKELQKNLLDAQkHNSDINlyLNEIANI-YNILKLNKIKKIIDEVKEYTKEIEEnnkNIKDELDKS 1388
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    528 CTEFKSPNNhfvvlDTAIETEKIHLERTrgldVHHTDVNLEVENNKTSFNSILN-ETAHNTYHNNNKDVSENEP--FKQF 604
Cdd:TIGR01612 1389 EKLIKKIKD-----DINLEECKSKIEST----LDDKDIDECIKKIKELKNHILSeESNIDTYFKNADENNENVLllFKNI 1459
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 83715968    605 RLLPGTREHALEKEitnSDQTKADLDSSL-DIKKNPVPCQKYSLRNSSNVmlddKQCKIKQIQLLTKKSECSILLSK 680
Cdd:TIGR01612 1460 EMADNKSQHILKIK---KDNATNDHDFNInELKEHIDKSKGCKDEADKNA----KAIEKNKELFEQYKKDVTELLNK 1529
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
245-434 1.38e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.44  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  245 KEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQRE 324
Cdd:COG4942   25 AEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKE 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  325 KVKE-----------NEEKFLNLQ---NEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEE 390
Cdd:COG4942  105 ELAEllralyrlgrqPPLALLLSPedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELE 184
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 83715968  391 DKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENF 434
Cdd:COG4942  185 EERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
GBP_C pfam02841
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ...
35-296 1.75e-03

Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.


Pssm-ID: 460721 [Multi-domain]  Cd Length: 297  Bit Score: 41.50  E-value: 1.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     35 LEALEELRMRREAEIHYEEQIGkiivetQELKWQKETLQNQKETLAEQHKEAMAVFKKQlqmkmcALEEEKGKYQ--LAT 112
Cdd:pfam02841   36 LAQIENSAAVQKAIAHYEQQMA------QKVKLPTETLQELLDLHRDCEKEAIAVFMKR------SFKDENQEFQkeLVE 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    113 EIKEKEIEGLKETLKAlqVSKYS---LQKKVSEMEQKVQLHLLAK----EDYHKQLSEIEKYYATITGQFGLVKENHEKL 185
Cdd:pfam02841  104 LLEAKKDDFLKQNEEA--SSKYCsalLQDLSEPLEEKISQGTFSKpggyKLFLEERDKLEAKYNQVPRKGVKAEEVLQEF 181
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    186 EQN---VREAI-QSNKRLSALNKKQEAEicSLKKELKKAASDLIKSKVTCQYKMGEEN-----INLTIKEQKFQELQERL 256
Cdd:pfam02841  182 LQSkeaVEEAIlQTDQALTAKEKAIEAE--RAKAEAAEAEQELLREKQKEEEQMMEAQersyqEHVKQLIEKMEAEREQL 259
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 83715968    257 NMElelNEKINEEitHIQEEKQDIIISFQHMQQLLRQQIQ 296
Cdd:pfam02841  260 LAE---QERMLEH--KLQEQEELLKEGFKTEAESLQKEIQ 294
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
51-416 1.82e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 42.41  E-value: 1.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     51 YEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKetlKALQ 130
Cdd:pfam15921  276 HEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIEELE---KQLV 352
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    131 VSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYyatiTGQFGLVKENHEKL-----------------------EQ 187
Cdd:pfam15921  353 LANSELTEARTERDQFSQESGNLDDQLQKLLADLHKR----EKELSLEKEQNKRLwdrdtgnsitidhlrrelddrnmEV 428
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    188 NVREAI----------QSNKRLSALNKKQE---------AEICSLKKELKKAASDLIKSKVT---CQYKMGEENINLTIK 245
Cdd:pfam15921  429 QRLEALlkamksecqgQMERQMAAIQGKNEslekvssltAQLESTKEMLRKVVEELTAKKMTlesSERTVSDLTASLQEK 508
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    246 EQKFQ-------ELQERLNMEL-ELNEKINEE--ITHIQEEKQDIIISFQHMQ---QLLRQQIQANTEMEA--------- 303
Cdd:pfam15921  509 ERAIEatnaeitKLRSRVDLKLqELQHLKNEGdhLRNVQTECEALKLQMAEKDkviEILRQQIENMTQLVGqhgrtagam 588
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    304 -------------------ELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNE 364
Cdd:pfam15921  589 qvekaqlekeindrrlelqEFKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNE 668
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 83715968    365 LSSLKETHIKLQEHYnklcnQKTFEEDKKFQNVPEVNNENSEMSTEKSENTI 416
Cdd:pfam15921  669 LNSLSEDYEVLKRNF-----RNKSEEMETTTNKLKMQLKSAQSELEQTRNTL 715
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
36-280 1.88e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 42.32  E-value: 1.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     36 EALEELRMRREAEIhyeeqigkiivetQELKWQKETLQNQKETLAEQhkeamavfKKQLQMKMCALEEEKGKYQLATEIK 115
Cdd:pfam05667  324 ETEEELQQQREEEL-------------EELQEQLEDLESSIQELEKE--------IKKLESSIKQVEEELEELKEQNEEL 382
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    116 EKEIEGLKETLKAL-----QVSKysLQKKVSEMEQKVQlhllakedyhkQLS-EIEKYYATitgqfgLVKEnHEKLEQnv 189
Cdd:pfam05667  383 EKQYKVKKKTLDLLpdaeeNIAK--LQALVDASAQRLV-----------ELAgQWEKHRVP------LIEE-YRALKE-- 440
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    190 reaIQSNKRLSAlnKKQEAEICSLKKELKKAASDlikskvtcqykmgeeninLTIKEQKFQELQ---ERLNMEL---ELN 263
Cdd:pfam05667  441 ---AKSNKEDES--QRKLEEIKELREKIKEVAEE------------------AKQKEELYKQLVaeyERLPKDVsrsAYT 497
                          250
                   ....*....|....*..
gi 83715968    264 EKINEEITHIQEEKQDI 280
Cdd:pfam05667  498 RRILEIVKNIKKQKEEI 514
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
35-328 2.08e-03

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 41.56  E-value: 2.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     35 LEALEELRMRREAEIHYEEQIGKIIVETQELKW--QKETLQNQ-KETLAEQHKEAMAvfKKQLQMKMCALEEE---KGKY 108
Cdd:pfam15558   64 QAEKEQRKARLGREERRRADRREKQVIEKESRWreQAEDQENQrQEKLERARQEAEQ--RKQCQEQRLKEKEEelqALRE 141
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    109 QLATEIKEKEIEG-----LKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYH-KQLSEIEKYYATITGQFGLVKENH 182
Cdd:pfam15558  142 QNSLQLQERLEEAchkrqLKEREEQKKVQENNLSELLNHQARKVLVDCQAKAEELlRRLSLEQSLQRSQENYEQLVEERH 221
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    183 EKLEQNVREAIQSNKRLSALNKKQEAEicslKKELKKAASDLIKSKVtcqyKMGEENINLTIKEqKFQELQErLNMELEL 262
Cdd:pfam15558  222 RELREKAQKEEEQFQRAKWRAEEKEEE----RQEHKEALAELADRKI----QQARQVAHKTVQD-KAQRARE-LNLEREK 291
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 83715968    263 NEKIN------EEITHIQEEKQDIIISFQHMQQLLRQQiqantemEAELkvlkENNQTLERDNELQREKVKE 328
Cdd:pfam15558  292 NHHILklkvekEEKCHREGIKEAIKKKEQRSEQISREK-------EATL----EEARKTARASFHMREKVRE 352
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
178-369 2.28e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 2.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  178 VKENHEKLEQNVREAIQSNKRLSALN-KKQEAEICSLKKELKKAASDLikskvtcqykmGEENINLTIKEQKFQELQERL 256
Cdd:COG4913  257 IRELAERYAAARERLAELEYLRAALRlWFAQRRLELLEAELEELRAEL-----------ARLEAELERLEARLDALREEL 325
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  257 nmeLELNEKINE----EITHIQEEKQdiiisfqHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEK 332
Cdd:COG4913  326 ---DELEAQIRGnggdRLEQLEREIE-------RLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEA 395
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 83715968  333 FLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLK 369
Cdd:COG4913  396 LEEELEALEEALAEAEAALRDLRRELRELEAEIASLE 432
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
52-375 2.65e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.82  E-value: 2.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   52 EEQIGKIIVETQELKWQKETLQNQKETLAEQHKeamavfkkqlqmkmcALEEEKGKYQLATEIKEKEIEglketlkalqv 131
Cdd:COG4913  609 RAKLAALEAELAELEEELAEAEERLEALEAELD---------------ALQERREALQRLAEYSWDEID----------- 662
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  132 sKYSLQKKVSEMEQKVQlHLLAKEDYHKQLSEiekyyatitgqfgLVKENHEKLEQNVREAIQSNKRLSALNKKQEaEIC 211
Cdd:COG4913  663 -VASAEREIAELEAELE-RLDASSDDLAALEE-------------QLEELEAELEELEEELDELKGEIGRLEKELE-QAE 726
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  212 SLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELE-LNEKINEEITHIQEEKQDIIISFQHMQQL 290
Cdd:COG4913  727 EELDELQDRLEAAEDLARLELRALLEERFAAALGDAVERELRENLEERIDaLRARLNRAEEELERAMRAFNREWPAETAD 806
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  291 LRQQIQANTEMEAELkvlkennqtlerdNELQREKVKENEEKFLNLQNEHEK--------ALGTWKRHAEElngEINKIK 362
Cdd:COG4913  807 LDADLESLPEYLALL-------------DRLEEDGLPEYEERFKELLNENSIefvadllsKLRRAIREIKE---RIDPLN 870
                        330
                 ....*....|....*.
gi 83715968  363 NELSSLK---ETHIKL 375
Cdd:COG4913  871 DSLKRIPfgpGRYLRL 886
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
31-210 3.17e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 3.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   31 KTSLLEALEELRMR---REAEIH-YEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAM-AVFKKQLQMKMCALEEEK 105
Cdd:COG4942   50 EKALLKQLAALERRiaaLARRIRaLEQELAALEAELAELEKEIAELRAELEAQKEELAELLrALYRLGRQPPLALLLSPE 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  106 GKYQLA---------TEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFg 176
Cdd:COG4942  130 DFLDAVrrlqylkylAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKEL- 208
                        170       180       190
                 ....*....|....*....|....*....|....
gi 83715968  177 lvkenhEKLEQNVREAIQSNKRLSALNKKQEAEI 210
Cdd:COG4942  209 ------AELAAELAELQQEAEELEALIARLEAEA 236
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
116-344 3.82e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.97  E-value: 3.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  116 EKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLhllAKEDYHKQLSEIEKyyatitgqfglVKENHEKLEQNVREAiqs 195
Cdd:COG3883   15 DPQIQAKQKELSELQAELEAAQAELDALQAELEE---LNEEYNELQAELEA-----------LQAEIDKLQAEIAEA--- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  196 nkrlsalnkkqEAEICSLKKELKKAASDLIKSKVTCQYkmgeenINLTIKEQKFQELQERLNMelelnekineeITHIQE 275
Cdd:COG3883   78 -----------EAEIEERREELGERARALYRSGGSVSY------LDVLLGSESFSDFLDRLSA-----------LSKIAD 129
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 83715968  276 EKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLErdNELQReKVKENEEKFLNLQNEHEKAL 344
Cdd:COG3883  130 ADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAK--AELEA-QQAEQEALLAQLSAEEAAAE 195
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
26-382 4.80e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 4.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     26 QLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQ----NQKETLAEQHKEAMAVFKKQLQMKMCAL 101
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEdrreRLQQEIEELLKKLEEAELKELQAELEEL 445
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    102 EEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKV---QLHLLAKEDYHKQLSEIEKYYATITGQFGLV 178
Cdd:TIGR02168  446 EEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLdslERLQENLEGFSEGVKALLKNQSGLSGILGVL 525
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    179 KEN---HEKLE-------------------QNVREAIQSNKR-------LSALNKKQEAEICSLKKELKK-------AAS 222
Cdd:TIGR02168  526 SELisvDEGYEaaieaalggrlqavvvenlNAAKKAIAFLKQnelgrvtFLPLDSIKGTEIQGNDREILKniegflgVAK 605
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    223 DLIKSKVTCQ-----------------------------------------------YKMGEENINLTIKEQKFQELQER 255
Cdd:TIGR02168  606 DLVKFDPKLRkalsyllggvlvvddldnalelakklrpgyrivtldgdlvrpggvitGGSAKTNSSILERRREIEELEEK 685
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    256 LNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLN 335
Cdd:TIGR02168  686 IEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEE 765
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 83715968    336 LQNEHEKA---LGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKL 382
Cdd:TIGR02168  766 LEERLEEAeeeLAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLL 815
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
179-424 5.14e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 40.71  E-value: 5.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  179 KENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKS--KVTCQYKMGEENINLTIKEQKFQELQERL 256
Cdd:COG5185  307 IKKATESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENleAIKEEIENIVGEVELSKSSEELDSFKDTI 386
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  257 NmelELNEKINEEITHIQEEKQDIIISFQ-HMQQLLRQQIQANTEMEAELKVLKENNQTL-ERDNELQREKVKENEEKFL 334
Cdd:COG5185  387 E---STKESLDEIPQNQRGYAQEILATLEdTLKAADRQIEELQRQIEQATSSNEEVSKLLnELISELNKVMREADEESQS 463
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968  335 NLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSEN 414
Cdd:COG5185  464 RLEEAYDEINRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFMRARGYAHILALEN 543
                        250
                 ....*....|
gi 83715968  415 TIIQKYNTEQ 424
Cdd:COG5185  544 LIPASELIQA 553
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
107-328 5.51e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 40.65  E-value: 5.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    107 KYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLE 186
Cdd:pfam07888   49 AQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHE 128
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    187 QNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKvtcqykmgEENINLTIKEQKFQELQERLNMEL-ELNEK 265
Cdd:pfam07888  129 ARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEE--------AERKQLQAKLQQTEEELRSLSKEFqELRNS 200
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 83715968    266 INEEITHIQEEKQDIiisfQHMQQLLRQQIQANTEMEA---ELKVLKENNQTLERDNELQREKVKE 328
Cdd:pfam07888  201 LAQRDTQVLQLQDTI----TTLTQKLTTAHRKEAENEAlleELRSLQERLNASERKVEGLGEELSS 262
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
25-148 5.67e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 5.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   25 IQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQhkeamavfKKQLQMKMCALEEE 104
Cdd:COG4942  122 LALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEAL--------LAELEEERAALEAL 193
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 83715968  105 KGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQ 148
Cdd:COG4942  194 KAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAA 237
PRK12704 PRK12704
phosphodiesterase; Provisional
108-315 7.88e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.15  E-value: 7.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   108 YQLATEIKEKEIEGLKETLKALqvskysLQKKVSEMEQKVQLHLL-AKEDYHKQLSEIEKYYAtitgqfglVKENH-EKL 185
Cdd:PRK12704   22 YFVRKKIAEAKIKEAEEEAKRI------LEEAKKEAEAIKKEALLeAKEEIHKLRNEFEKELR--------ERRNElQKL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   186 EQNVREAIQSNKRLSALNKKQEAEICSLKKELKKaasdlikskvtcqykmgeeninltiKEQKFQELQERLNmelELNEK 265
Cdd:PRK12704   88 EKRLLQKEENLDRKLELLEKREEELEKKEKELEQ-------------------------KQQELEKKEEELE---ELIEE 139
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 83715968   266 INEEITHI----QEEKQDIIIsfQHMQQLLRQQIQA---NTEMEAELKVLKENNQTL 315
Cdd:PRK12704  140 QLQELERIsgltAEEAKEILL--EKVEEEARHEAAVlikEIEEEAKEEADKKAKEIL 194
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
84-369 8.24e-03

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 40.01  E-value: 8.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968     84 KEAMAVFKKQLQmkmcALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQK-------KVSEMEQKV--QLHLLAK 154
Cdd:pfam05701   48 QEEIPEYKKQSE----AAEAAKAQVLEELESTKRLIEELKLNLERAQTEEAQAKQdselaklRVEEMEQGIadEASVAAK 123
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    155 EdyhkQLSEIEKYYATITGQFGLVKENHEKLeQNVREAIQSNKRLsALNKKQEAEICSlkKELKKAASDL----IKSKvt 230
Cdd:pfam05701  124 A----QLEVAKARHAAAVAELKSVKEELESL-RKEYASLVSERDI-AIKRAEEAVSAS--KEIEKTVEELtielIATK-- 193
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    231 cqykmgeENIN------LTIKEQKFQEL----QERLNMELELNekineeitHIQEEKQDiiisfqhmqqlLRQQIQANTE 300
Cdd:pfam05701  194 -------ESLEsahaahLEAEEHRIGAAlareQDKLNWEKELK--------QAEEELQR-----------LNQQLLSAKD 247
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 83715968    301 MEAELKVLKENNQTLERD------NELQREKVKENEEKflNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLK 369
Cdd:pfam05701  248 LKSKLETASALLLDLKAElaaymeSKLKEEADGEGNEK--KTSTSIQAALASAKKELEEVKANIEKAKDEVNCLR 320
PRK12704 PRK12704
phosphodiesterase; Provisional
55-226 9.52e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 39.76  E-value: 9.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968    55 IGKIIVETQELKWQKETlqnqKETLAEQHKEAMAVFK-KQLQMKMcalEEEKGKYQLATEIKEKEIEgLKETLKALQVSK 133
Cdd:PRK12704   24 VRKKIAEAKIKEAEEEA----KRILEEAKKEAEAIKKeALLEAKE---EIHKLRNEFEKELRERRNE-LQKLEKRLLQKE 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715968   134 YSLQKKVSEMEQKVQlhllakedyhkqlsEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEIC-- 211
Cdd:PRK12704   96 ENLDRKLELLEKREE--------------ELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLTAEEAKEILle 161
                         170
                  ....*....|....*
gi 83715968   212 SLKKELKKAASDLIK 226
Cdd:PRK12704  162 KVEEEARHEAAVLIK 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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