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Conserved domains on  [gi|1939401961|ref|NP_001007636|]
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GTPase activating protein testicular GAP1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 189-380 7.24e-68

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239867  Cd Length: 192  Bit Score: 226.41  E-value: 7.24e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  189 LFGRELSSICQDGDLPSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEVDIEKQSVHVVAWIFKDFLQNI 268
Cdd:cd04402      1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  269 EGSLMTSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVP 348
Cdd:cd04402     81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWPP 160

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1939401961  349 SSCNNGMtNDISKKISLVKFMIENSPQFFGED 380
Cdd:cd04402    161 ASSELQN-EDLKKVTSLVQFLIENCQEIFGED 191
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 1027-1216 3.91e-60

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04402:

Pssm-ID: 470621  Cd Length: 192  Bit Score: 204.45  E-value: 3.91e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1027 LFGKNLTSIYVDSKLPAPILEMLSIIAEKGKESDQIFAILPENSH-WSLRERIESEELIDWNEEGILVIASVLKDFITNI 1105
Cdd:cd04402      1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKAcKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1106 EGSLLTSDLYESWLSVPDEGTLAGKINAIQRLLLKIPQANFILLKHLICVLVKI-RDSSMNNLDSNNLSVRIAPYVLWNQ 1184
Cdd:cd04402     81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNIsQNSETNKMDAFNLAVCIAPSLLWPP 160

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1939401961 1185 TPKdTLFGSDVSRKMSIIQIMIDNYSQIFGND 1216
Cdd:cd04402    161 ASS-ELQNEDLKKVTSLVQFLIENCQEIFGED 191
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 752-942 9.64e-58

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04402:

Pssm-ID: 470621  Cd Length: 192  Bit Score: 197.52  E-value: 9.64e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  752 LFGQPLTSIFEDKKIPTPIFDMLSIIAEKGKDTDHIF-KTLSEYSHWSLRDKIDTYQYINWNEERVLVIASVLKDFITHI 830
Cdd:cd04402      1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFrRSANAKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  831 DGSLLTCELYESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVLVIIKDSS-TNKLDTNRLSLRLGPHLLWGW 909
Cdd:cd04402     81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSeTNKMDAFNLAVCIAPSLLWPP 160

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1939401961  910 TSSDAfFGKNVSRKLSIIQIMIDNYHQIFGNDD 942
Cdd:cd04402    161 ASSEL-QNEDLKKVTSLVQFLIENCQEIFGEDI 192
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 476-666 5.77e-55

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04402:

Pssm-ID: 470621  Cd Length: 192  Bit Score: 189.82  E-value: 5.77e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  476 LFGKSLTSLFEDKKLPTPILDMLSIIAEKGHESDHIFKILPKESH-WSLRYRLDSEQHIDWDEECVLVIASVLKDFIINI 554
Cdd:cd04402      1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKAcKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  555 DGSLLTLEFYENWLSIPDEGTLAEKINAIQSLLQQIPEPNFILLKHLVYVLVIIKDSSMNN-LDSYRLSLRIAPHVLWGK 633
Cdd:cd04402     81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNkMDAFNLAVCIAPSLLWPP 160

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1939401961  634 TSRDsLFGTDVLRKLSIMQIMIDNYHEIFGNDD 666
Cdd:cd04402    161 ASSE-LQNEDLKKVTSLVQFLIENCQEIFGEDI 192
Ubl1_cv_Nsp3_N-like super family cl28922
first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV ...
 25-139 8.65e-12

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.


The actual alignment was detected with superfamily member cd17115:

Pssm-ID: 475130  Cd Length: 117  Bit Score: 63.12  E-value: 8.65e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961   25 EIPMQIFTEDIACCDTPLYVTATNFDTVNDIISKLLPMIR-KHNTEDYQLWFCPGPGKAPRLLQGHEYPHDIRMINIQKN 103
Cdd:cd17115      2 SIPLKVLNRDVGSCAYSKTLTVSNTDTAKDVIKMALQQFGiTGDPSDYQLWVKSGKEESPYPLIGHEYPFSIKMSHLRDA 81

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1939401961  104 FSSRDLRNFTAVPSLPGVIMKYLNADVHGKFILKPR 139
Cdd:cd17115     82 ARQSDGDNLNILDLDHLSSMENLPPEAQCQFILRPS 117
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 189-380 7.24e-68

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 226.41  E-value: 7.24e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  189 LFGRELSSICQDGDLPSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEVDIEKQSVHVVAWIFKDFLQNI 268
Cdd:cd04402      1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  269 EGSLMTSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVP 348
Cdd:cd04402     81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWPP 160

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1939401961  349 SSCNNGMtNDISKKISLVKFMIENSPQFFGED 380
Cdd:cd04402    161 ASSELQN-EDLKKVTSLVQFLIENCQEIFGED 191
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1027-1216 3.91e-60

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 204.45  E-value: 3.91e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1027 LFGKNLTSIYVDSKLPAPILEMLSIIAEKGKESDQIFAILPENSH-WSLRERIESEELIDWNEEGILVIASVLKDFITNI 1105
Cdd:cd04402      1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKAcKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1106 EGSLLTSDLYESWLSVPDEGTLAGKINAIQRLLLKIPQANFILLKHLICVLVKI-RDSSMNNLDSNNLSVRIAPYVLWNQ 1184
Cdd:cd04402     81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNIsQNSETNKMDAFNLAVCIAPSLLWPP 160

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1939401961 1185 TPKdTLFGSDVSRKMSIIQIMIDNYSQIFGND 1216
Cdd:cd04402    161 ASS-ELQNEDLKKVTSLVQFLIENCQEIFGED 191
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 752-942 9.64e-58

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 197.52  E-value: 9.64e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  752 LFGQPLTSIFEDKKIPTPIFDMLSIIAEKGKDTDHIF-KTLSEYSHWSLRDKIDTYQYINWNEERVLVIASVLKDFITHI 830
Cdd:cd04402      1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFrRSANAKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  831 DGSLLTCELYESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVLVIIKDSS-TNKLDTNRLSLRLGPHLLWGW 909
Cdd:cd04402     81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSeTNKMDAFNLAVCIAPSLLWPP 160

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1939401961  910 TSSDAfFGKNVSRKLSIIQIMIDNYHQIFGNDD 942
Cdd:cd04402    161 ASSEL-QNEDLKKVTSLVQFLIENCQEIFGEDI 192
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 476-666 5.77e-55

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 189.82  E-value: 5.77e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  476 LFGKSLTSLFEDKKLPTPILDMLSIIAEKGHESDHIFKILPKESH-WSLRYRLDSEQHIDWDEECVLVIASVLKDFIINI 554
Cdd:cd04402      1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKAcKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  555 DGSLLTLEFYENWLSIPDEGTLAEKINAIQSLLQQIPEPNFILLKHLVYVLVIIKDSSMNN-LDSYRLSLRIAPHVLWGK 633
Cdd:cd04402     81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNkMDAFNLAVCIAPSLLWPP 160

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1939401961  634 TSRDsLFGTDVLRKLSIMQIMIDNYHEIFGNDD 666
Cdd:cd04402    161 ASSE-LQNEDLKKVTSLVQFLIENCQEIFGEDI 192
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 204-349 6.83e-32

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 121.88  E-value: 6.83e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  204 PSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEV--DIEKQSVHVVAWIFKDFLQNIEGSLMTSKLYDEW 281
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVdlDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1939401961  282 IAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVPS 349
Cdd:pfam00620   81 IEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 201-373 2.93e-29

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 115.44  E-value: 2.93e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961   201 GDLPSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEVDI--EKQSVHVVAWIFKDFLQNIEGSLMTSKLY 278
Cdd:smart00324    1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLdlSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961   279 DEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVPSSCNNGMTnD 358
Cdd:smart00324   81 EEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVASLK-D 159

                           170
                    ....*....|....*
gi 1939401961   359 ISKKISLVKFMIENS 373
Cdd:smart00324  160 IRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 1042-1185 2.12e-20

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 88.76  E-value: 2.12e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1042 PAPILEMLSIIAEKGKESDQIFAILPENSHWS-LRERIESEE--LIDWNEEGILVIASVLKDFITNIEGSLLTSDLYESW 1118
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKeLREAFDRGPdvDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1939401961 1119 LSVPDEGTLAGKINAIQRLLLKIPQANFILLKHLICVLVKIRD-SSMNNLDSNNLSVRIAPYVLWNQT 1185
Cdd:pfam00620   81 IEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQnSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 491-631 1.09e-19

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 86.83  E-value: 1.09e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  491 PTPILDMLSIIAEKGHESDHIFKILPKESH---WSLRYRLDSEQHIDWDEECVLVIASVLKDFIINIDGSLLTLEFYENW 567
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRikeLREAFDRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1939401961  568 LSIPDEGTLAEKINAIQSLLQQIPEPNFILLKHLVYVLV-IIKDSSMNNLDSYRLSLRIAPHVLW 631
Cdd:pfam00620   81 IEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNrVAQNSDVNKMNAHNLAIVFGPTLLR 145
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 767-907 3.74e-18

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 82.59  E-value: 3.74e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  767 PTPIFDMLSIIAEKGKDTDHIF------KTLSEyshwsLRDKIDTYQY--INWNEERVLVIASVLKDFITHIDGSLLTCE 838
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFrvsgsaSRIKE-----LREAFDRGPDvdLDLEEEDVHVVASLLKLFLRELPEPLLTFE 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  839 LYESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVLV-IIKDSSTNKLDTNRLSLRLGPHLLW 907
Cdd:pfam00620   76 LYEEFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNrVAQNSDVNKMNAHNLAIVFGPTLLR 145
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 1041-1209 2.65e-17

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 80.77  E-value: 2.65e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  1041 LPAPILEMLSIIAEKGKESDQIFAILPENSHW-SLRERIESEELID--WNEEGILVIASVLKDFITNIEGSLLTSDLYES 1117
Cdd:smart00324    3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVkELRDAFDSGPDPDldLSEYDVHDVAGLLKLFLRELPEPLITYELYEE 82

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  1118 WLSVPDEGTLAGKINAIQRLLLKIPQANFILLKHLICVLVKI-RDSSMNNLDSNNLSVRIAPYVLWNQtPKDTLFGSDVS 1196
Cdd:smart00324   83 FIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVaEHSEENKMTARNLAIVFGPTLLRPP-DGEVASLKDIR 161

                           170
                    ....*....|...
gi 1939401961  1197 RKMSIIQIMIDNY 1209
Cdd:smart00324  162 HQNTVIEFLIENA 174
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 764-934 1.52e-14

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 73.07  E-value: 1.52e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961   764 KKIPTPIFDMLSIIAEKGKDTDHIFKTLSEYSHW-SLRDKIDTYQYIN--WNEERVLVIASVLKDFITHIDGSLLTCELY 840
Cdd:smart00324    1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVkELRDAFDSGPDPDldLSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961   841 ESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVLV-IIKDSSTNKLDTNRLSLRLGPHLLWGwTSSDAFFGKN 919
Cdd:smart00324   81 EEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNrVAEHSEENKMTARNLAIVFGPTLLRP-PDGEVASLKD 159

                           170
                    ....*....|....*
gi 1939401961   920 VSRKLSIIQIMIDNY 934
Cdd:smart00324  160 IRHQNTVIEFLIENA 174
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 488-658 1.97e-14

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 72.68  E-value: 1.97e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961   488 KKLPTPILDMLSIIAEKGHESDHIF-KILPKESHWSLRYRLDSEQHIDWDEEC--VLVIASVLKDFIINIDGSLLTLEFY 564
Cdd:smart00324    1 KPIPIIVEKCIEYLEKRGLDTEGIYrVSGSKSRVKELRDAFDSGPDPDLDLSEydVHDVAGLLKLFLRELPEPLITYELY 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961   565 ENWLSIPDEGTLAEKINAIQSLLQQIPEPNFILLKHLVYVLV-IIKDSSMNNLDSYRLSLRIAPHVLW-GKTSRDSLFGT 642
Cdd:smart00324   81 EEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNrVAEHSEENKMTARNLAIVFGPTLLRpPDGEVASLKDI 160

                           170
                    ....*....|....*.
gi 1939401961   643 DVLRKlsIMQIMIDNY 658
Cdd:smart00324  161 RHQNT--VIEFLIENA 174
RA_RHG20 cd17115
Ras-associating (RA) domain found in Rho GTPase-activating protein 20 (RHG20) and similar ...
 25-139 8.65e-12

Ras-associating (RA) domain found in Rho GTPase-activating protein 20 (RHG20) and similar proteins; RHG20, also termed ARHGAP20, is one of GTPase activating proteins for Rho family proteins (RhoGAPs). It contains a PH-like domain, an RA domain, a RhoGap domain, and two Annexin-like (ANXL) repeats. RA domain has the beta-grasp ubiquitin-like fold with low sequence similarity to ubiquitin that is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair in eukaryotes.


Pssm-ID: 340635  Cd Length: 117  Bit Score: 63.12  E-value: 8.65e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961   25 EIPMQIFTEDIACCDTPLYVTATNFDTVNDIISKLLPMIR-KHNTEDYQLWFCPGPGKAPRLLQGHEYPHDIRMINIQKN 103
Cdd:cd17115      2 SIPLKVLNRDVGSCAYSKTLTVSNTDTAKDVIKMALQQFGiTGDPSDYQLWVKSGKEESPYPLIGHEYPFSIKMSHLRDA 81

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1939401961  104 FSSRDLRNFTAVPSLPGVIMKYLNADVHGKFILKPR 139
Cdd:cd17115     82 ARQSDGDNLNILDLDHLSSMENLPPEAQCQFILRPS 117
RA pfam00788
Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); ...
 28-97 1.54e-05

Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.


Pssm-ID: 425871  Cd Length: 93  Bit Score: 44.63  E-value: 1.54e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1939401961   28 MQIFTEDIACCDTPLYVTATNFDTVNDIISKLLPMIR-KHNTEDYQLWFCPGPGKAPRLLQGHEYPHDIRM 97
Cdd:pfam00788    5 LKVYTEDGKPGTTYKTILVSSSTTAEEVIEALLEKFGlEDDPRDYVLVEVLERGGGERRLPDDECPLQIQL 75
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 189-380 7.24e-68

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 226.41  E-value: 7.24e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  189 LFGRELSSICQDGDLPSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEVDIEKQSVHVVAWIFKDFLQNI 268
Cdd:cd04402      1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  269 EGSLMTSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVP 348
Cdd:cd04402     81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWPP 160

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1939401961  349 SSCNNGMtNDISKKISLVKFMIENSPQFFGED 380
Cdd:cd04402    161 ASSELQN-EDLKKVTSLVQFLIENCQEIFGED 191
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1027-1216 3.91e-60

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 204.45  E-value: 3.91e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1027 LFGKNLTSIYVDSKLPAPILEMLSIIAEKGKESDQIFAILPENSH-WSLRERIESEELIDWNEEGILVIASVLKDFITNI 1105
Cdd:cd04402      1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKAcKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1106 EGSLLTSDLYESWLSVPDEGTLAGKINAIQRLLLKIPQANFILLKHLICVLVKI-RDSSMNNLDSNNLSVRIAPYVLWNQ 1184
Cdd:cd04402     81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNIsQNSETNKMDAFNLAVCIAPSLLWPP 160

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1939401961 1185 TPKdTLFGSDVSRKMSIIQIMIDNYSQIFGND 1216
Cdd:cd04402    161 ASS-ELQNEDLKKVTSLVQFLIENCQEIFGED 191
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 752-942 9.64e-58

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 197.52  E-value: 9.64e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  752 LFGQPLTSIFEDKKIPTPIFDMLSIIAEKGKDTDHIF-KTLSEYSHWSLRDKIDTYQYINWNEERVLVIASVLKDFITHI 830
Cdd:cd04402      1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFrRSANAKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  831 DGSLLTCELYESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVLVIIKDSS-TNKLDTNRLSLRLGPHLLWGW 909
Cdd:cd04402     81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSeTNKMDAFNLAVCIAPSLLWPP 160

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1939401961  910 TSSDAfFGKNVSRKLSIIQIMIDNYHQIFGNDD 942
Cdd:cd04402    161 ASSEL-QNEDLKKVTSLVQFLIENCQEIFGEDI 192
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 476-666 5.77e-55

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 189.82  E-value: 5.77e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  476 LFGKSLTSLFEDKKLPTPILDMLSIIAEKGHESDHIFKILPKESH-WSLRYRLDSEQHIDWDEECVLVIASVLKDFIINI 554
Cdd:cd04402      1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKAcKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  555 DGSLLTLEFYENWLSIPDEGTLAEKINAIQSLLQQIPEPNFILLKHLVYVLVIIKDSSMNN-LDSYRLSLRIAPHVLWGK 633
Cdd:cd04402     81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNkMDAFNLAVCIAPSLLWPP 160

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1939401961  634 TSRDsLFGTDVLRKLSIMQIMIDNYHEIFGNDD 666
Cdd:cd04402    161 ASSE-LQNEDLKKVTSLVQFLIENCQEIFGEDI 192
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 204-372 2.49e-34

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 129.73  E-value: 2.49e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  204 PSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEV-DIEKQSVHVVAWIFKDFLQNIEGSLMTSKLYDEWI 282
Cdd:cd00159      1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIdDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  283 AVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPClLFVPSSCNNGMTNDISKK 362
Cdd:cd00159     81 ELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPT-LLRPPDSDDELLEDIKKL 159

                          170
                   ....*....|
gi 1939401961  363 ISLVKFMIEN 372
Cdd:cd00159    160 NEIVEFLIEN 169
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 204-349 6.83e-32

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 121.88  E-value: 6.83e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  204 PSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEV--DIEKQSVHVVAWIFKDFLQNIEGSLMTSKLYDEW 281
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVdlDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1939401961  282 IAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVPS 349
Cdd:pfam00620   81 IEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 201-373 2.93e-29

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 115.44  E-value: 2.93e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961   201 GDLPSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEVDI--EKQSVHVVAWIFKDFLQNIEGSLMTSKLY 278
Cdd:smart00324    1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLdlSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961   279 DEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVPSSCNNGMTnD 358
Cdd:smart00324   81 EEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVASLK-D 159

                           170
                    ....*....|....*
gi 1939401961   359 ISKKISLVKFMIENS 373
Cdd:smart00324  160 IRHQNTVIEFLIENA 174
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 190-371 9.87e-22

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 94.04  E-value: 9.87e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  190 FGRELSSIC-QDGDLPSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSG-EEVDIEKQSVHVVAWIFKDFLQN 267
Cdd:cd04377      1 FGVSLSSLTsEDRSVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDpDSVNLEDYPIHVITSVLKQWLRE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  268 IEGSLMTSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFV 347
Cdd:cd04377     81 LPEPLMTFELYENFLRAMELEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFAPCILRC 160

                          170       180
                   ....*....|....*....|....*
gi 1939401961  348 PSSCNNGMT-NDISKKISLVKFMIE 371
Cdd:cd04377    161 PDTADPLQSlQDVSKTTTCVETLIK 185
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 1042-1208 7.65e-21

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 90.82  E-value: 7.65e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1042 PAPILEMLSIIAEKGKESDQIFAILPENSHW-SLRERIESEELI-DWNEEGILVIASVLKDFITNIEGSLLTSDLYESWL 1119
Cdd:cd00159      1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIeELKKKFDRGEDIdDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1120 SVPDEGTLAGKINAIQRLLLKIPQANFILLKHLICVLVKI-RDSSMNNLDSNNLSVRIAPYVLWNQTPKDTLFgSDVSRK 1198
Cdd:cd00159     81 ELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKIsQNSEVNKMTASNLAIVFAPTLLRPPDSDDELL-EDIKKL 159

                          170
                   ....*....|
gi 1939401961 1199 MSIIQIMIDN 1208
Cdd:cd00159    160 NEIVEFLIEN 169
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 1042-1185 2.12e-20

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 88.76  E-value: 2.12e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1042 PAPILEMLSIIAEKGKESDQIFAILPENSHWS-LRERIESEE--LIDWNEEGILVIASVLKDFITNIEGSLLTSDLYESW 1118
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKeLREAFDRGPdvDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1939401961 1119 LSVPDEGTLAGKINAIQRLLLKIPQANFILLKHLICVLVKIRD-SSMNNLDSNNLSVRIAPYVLWNQT 1185
Cdd:pfam00620   81 IEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQnSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 213-380 2.71e-20

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 90.59  E-value: 2.71e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  213 LLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGE---EVDIEKQSVHVVAWIFKDFLQNIEGSLMTSKLYDEWIAVTEKVN 289
Cdd:cd04386     30 CLLETGMNEEGLFRVGGGASKLKRLKAALDAGTfslPLDEFYSDPHAVASALKSYLRELPDPLLTYNLYEDWVQAANKPD 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  290 DEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVPSSCNNGMTNDISKK--ISLVK 367
Cdd:cd04386    110 EDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAIVLAPNLLWAKNEGSLAEMAAGTSVhvVAIVE 189

                          170
                   ....*....|...
gi 1939401961  368 FMIENSPQFFGED 380
Cdd:cd04386    190 LIISHADWFFPGE 202
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 767-933 4.69e-20

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 88.51  E-value: 4.69e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  767 PTPIFDMLSIIAEKGKDTDHIFKTLSEYSHW-SLRDKIDTYQYI-NWNEERVLVIASVLKDFITHIDGSLLTCELYESWL 844
Cdd:cd00159      1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIeELKKKFDRGEDIdDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  845 SVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVLV-IIKDSSTNKLDTNRLSLRLGPHLLWGwTSSDAFFGKNVSRK 923
Cdd:cd00159     81 ELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHkISQNSEVNKMTASNLAIVFAPTLLRP-PDSDDELLEDIKKL 159

                          170
                   ....*....|
gi 1939401961  924 LSIIQIMIDN 933
Cdd:cd00159    160 NEIVEFLIEN 169
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 491-631 1.09e-19

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 86.83  E-value: 1.09e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  491 PTPILDMLSIIAEKGHESDHIFKILPKESH---WSLRYRLDSEQHIDWDEECVLVIASVLKDFIINIDGSLLTLEFYENW 567
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRikeLREAFDRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1939401961  568 LSIPDEGTLAEKINAIQSLLQQIPEPNFILLKHLVYVLV-IIKDSSMNNLDSYRLSLRIAPHVLW 631
Cdd:pfam00620   81 IEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNrVAQNSDVNKMNAHNLAIVFGPTLLR 145
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 491-657 1.18e-19

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 87.36  E-value: 1.18e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  491 PTPILDMLSIIAEKGHESDHIFKILPKESHW-SLRYRLDSEQHIDWDEEC-VLVIASVLKDFIINIDGSLLTLEFYENWL 568
Cdd:cd00159      1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIeELKKKFDRGEDIDDLEDYdVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  569 SIPDEGTLAEKINAIQSLLQQIPEPNFILLKHLVYVLV-IIKDSSMNNLDSYRLSLRIAPHVLWGKTSRDSLFgTDVLRK 647
Cdd:cd00159     81 ELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHkISQNSEVNKMTASNLAIVFAPTLLRPPDSDDELL-EDIKKL 159

                          170
                   ....*....|
gi 1939401961  648 LSIMQIMIDN 657
Cdd:cd00159    160 NEIVEFLIEN 169
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 767-907 3.74e-18

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 82.59  E-value: 3.74e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  767 PTPIFDMLSIIAEKGKDTDHIF------KTLSEyshwsLRDKIDTYQY--INWNEERVLVIASVLKDFITHIDGSLLTCE 838
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFrvsgsaSRIKE-----LREAFDRGPDvdLDLEEEDVHVVASLLKLFLRELPEPLLTFE 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  839 LYESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVLV-IIKDSSTNKLDTNRLSLRLGPHLLW 907
Cdd:pfam00620   76 LYEEFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNrVAQNSDVNKMNAHNLAIVFGPTLLR 145
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 246-345 1.28e-17

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 81.97  E-value: 1.28e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  246 EVDIEKQSVHVVAWIFKDFLQNIEGSLMTSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNN 325
Cdd:cd04385     61 QLREGEYTVHDVADVLKRFLRDLPDPLLTSELHAEWIEAAELENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKH 140

                           90       100
                   ....*....|....*....|
gi 1939401961  326 SAVNEMSSYHLSVGLAPCLL 345
Cdd:cd04385    141 SDENQMSVHNLALVFGPTLF 160
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 1041-1209 2.65e-17

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 80.77  E-value: 2.65e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  1041 LPAPILEMLSIIAEKGKESDQIFAILPENSHW-SLRERIESEELID--WNEEGILVIASVLKDFITNIEGSLLTSDLYES 1117
Cdd:smart00324    3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVkELRDAFDSGPDPDldLSEYDVHDVAGLLKLFLRELPEPLITYELYEE 82

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  1118 WLSVPDEGTLAGKINAIQRLLLKIPQANFILLKHLICVLVKI-RDSSMNNLDSNNLSVRIAPYVLWNQtPKDTLFGSDVS 1196
Cdd:smart00324   83 FIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVaEHSEENKMTARNLAIVFGPTLLRPP-DGEVASLKDIR 161

                           170
                    ....*....|...
gi 1939401961  1197 RKMSIIQIMIDNY 1209
Cdd:smart00324  162 HQNTVIEFLIENA 174
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 214-350 5.84e-17

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 80.46  E-value: 5.84e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  214 LKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEVDIEK-QSVHVVAWIFKDFLQNIEGSLMTSKLYDEWIAVTEkVNDEE 292
Cdd:cd04404     34 LQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQyEDVHLPAVILKTFLRELPEPLLTFDLYDDIVGFLN-VDKEE 112

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1939401961  293 KLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVPSS 350
Cdd:cd04404    113 RVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPNLLWAKDA 170
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 188-372 1.07e-15

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 76.73  E-value: 1.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  188 KLFGRELSSICQDG----DLPSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEVDIEKQS-VHVVAWIFK 262
Cdd:cd04393      1 KVFGVPLQELQQAGqpenGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEAdVCSAASLLR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  263 DFLQNIEGSLMTSKLYDEWIAVTEKVN-DEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLA 341
Cdd:cd04393     81 LFLQELPEGLIPASLQIRLMQLYQDYNgEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAAVFG 160

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1939401961  342 PCLLFVPSSCNNGMTNDISKKIsLVKfMIEN 372
Cdd:cd04393    161 PDVFHVYTDVEDMKEQEICSRI-MAK-LLEN 189
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 190-370 3.60e-15

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 75.03  E-value: 3.60e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  190 FGRELSSICQD-GDLPSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSG-EEVDIEKQSVHVVAWIFKDFLQN 267
Cdd:cd04407      1 FGVRVGSLTSNkTSVPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADpENVKLENYPIHAITGLLKQWLRE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  268 IEGSLMTSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFV 347
Cdd:cd04407     81 LPEPLMTFAQYNDFLRAVELPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAPCLLRC 160

                          170       180
                   ....*....|....*....|....
gi 1939401961  348 PSSCNNGMT-NDISKKISLVKFMI 370
Cdd:cd04407    161 PDSSDPLTSmKDVAKTTTCVEMLI 184
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 187-362 1.16e-14

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 74.38  E-value: 1.16e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  187 GKLFGRELSSICQDGD--LPSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDS-GEEVDIEKQSVHVVAWIFKD 263
Cdd:cd04375      2 KNVFGVPLLVNLQRTGqpLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESsTDNVNYDGQQAYDVADMLKQ 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  264 FLQNIEGSLMTSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPC 343
Cdd:cd04375     82 YFRDLPEPLLTNKLSETFIAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCLAPS 161

                          170
                   ....*....|....*....
gi 1939401961  344 LLFVPSSCNNGMTNDISKK 362
Cdd:cd04375    162 LFHLNTSRRENSSPARRMQ 180
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 764-934 1.52e-14

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 73.07  E-value: 1.52e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961   764 KKIPTPIFDMLSIIAEKGKDTDHIFKTLSEYSHW-SLRDKIDTYQYIN--WNEERVLVIASVLKDFITHIDGSLLTCELY 840
Cdd:smart00324    1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVkELRDAFDSGPDPDldLSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961   841 ESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVLV-IIKDSSTNKLDTNRLSLRLGPHLLWGwTSSDAFFGKN 919
Cdd:smart00324   81 EEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNrVAEHSEENKMTARNLAIVFGPTLLRP-PDGEVASLKD 159

                           170
                    ....*....|....*
gi 1939401961   920 VSRKLSIIQIMIDNY 934
Cdd:smart00324  160 IRHQNTVIEFLIENA 174
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 190-370 1.67e-14

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 73.11  E-value: 1.67e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  190 FGRELSSIC-QDGDLPSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDS-GEEVDIEKQSVHVVAWIFKDFLQN 267
Cdd:cd04406      1 FGVELSRLTsEDRSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTdANSVNLDDYNIHVIASVFKQWLRD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  268 IEGSLMTSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFV 347
Cdd:cd04406     81 LPNPLMTFELYEEFLRAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPCILRC 160

                          170       180
                   ....*....|....*....|....
gi 1939401961  348 PSSCNNGMT-NDISKKISLVKFMI 370
Cdd:cd04406    161 PDTTDPLQSvQDISKTTTCVELIV 184
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 488-658 1.97e-14

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 72.68  E-value: 1.97e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961   488 KKLPTPILDMLSIIAEKGHESDHIF-KILPKESHWSLRYRLDSEQHIDWDEEC--VLVIASVLKDFIINIDGSLLTLEFY 564
Cdd:smart00324    1 KPIPIIVEKCIEYLEKRGLDTEGIYrVSGSKSRVKELRDAFDSGPDPDLDLSEydVHDVAGLLKLFLRELPEPLITYELY 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961   565 ENWLSIPDEGTLAEKINAIQSLLQQIPEPNFILLKHLVYVLV-IIKDSSMNNLDSYRLSLRIAPHVLW-GKTSRDSLFGT 642
Cdd:smart00324   81 EEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNrVAEHSEENKMTARNLAIVFGPTLLRpPDGEVASLKDI 160

                           170
                    ....*....|....*.
gi 1939401961   643 DVLRKlsIMQIMIDNY 658
Cdd:smart00324  161 RHQNT--VIEFLIENA 174
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 753-938 2.92e-14

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 72.76  E-value: 2.92e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  753 FGQPLTSIFE----DKKIPTPIFDMLSIIAEKGKDTDHIF-KTLSEYSHWSLRDKIDTYQYINW-NEERVLVIASVLKDF 826
Cdd:cd04404      6 FGVSLQFLKEknpeQEPIPPVVRETVEYLQAHALTTEGIFrRSANTQVVKEVQQKYNMGEPVDFdQYEDVHLPAVILKTF 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  827 ITHIDGSLLTCELYE---SWLSVPDEgtlaEQINAIQRLLQKIPEPNFILLKHLICVLVIIKD-SSTNKLDTNRLSLRLG 902
Cdd:cd04404     86 LRELPEPLLTFDLYDdivGFLNVDKE----ERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAhSDQNKMTNSNLAVVFG 161

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1939401961  903 PHLLWgwtSSDAffgknvSRKLSII-------QIMIDNYHQIF 938
Cdd:cd04404    162 PNLLW---AKDA------SMSLSAInpintftKFLLDHQDEIF 195
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 220-377 1.89e-13

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 70.57  E-value: 1.89e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  220 TTKGVFIEPPSTTLFQTVKDKLDSGEEVDIEKQ--SVHVVAWIFKDFLQNIEGSLMTSKLYDEWIAVTE----------- 286
Cdd:cd04392     25 RVEGLFRKPGNSARQQELRDLLNSGTDLDLESGgfHAHDCATVLKGFLGELPEPLLTHAHYPAHLQIADlcqfdekgnkt 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  287 KVNDEEKLV-AVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVPSSCNNGMTNDISKKISL 365
Cdd:cd04392    105 SAPDKERLLeALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRNLTPEDLHENAQKLNSI 184

                          170
                   ....*....|..
gi 1939401961  366 VKFMIENSPQFF 377
Cdd:cd04392    185 VTFMIKHSQKLF 196
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 753-931 2.88e-13

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 69.77  E-value: 2.88e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  753 FGQPLTSIF-EDKKIPTPIFDMLSIIAEKGKDTDHIF-KTLSEYSHWSLRDKIDT-YQYINWNEERVLVIASVLKDFITH 829
Cdd:cd04377      1 FGVSLSSLTsEDRSVPLVLEKLLEHIEMHGLYTEGIYrKSGSANKIKELRQGLDTdPDSVNLEDYPIHVITSVLKQWLRE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  830 IDGSLLTCELYESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVLVIIKD-SSTNKLDTNRLSLRLGPHLLWG 908
Cdd:cd04377     81 LPEPLMTFELYENFLRAMELEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALqEEVNRMSANALAIVFAPCILRC 160

                          170       180
                   ....*....|....*....|....
gi 1939401961  909 WTSSDAFFG-KNVSRKLSIIQIMI 931
Cdd:cd04377    161 PDTADPLQSlQDVSKTTTCVETLI 184
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 189-349 3.31e-13

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 69.69  E-value: 3.31e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  189 LFGREL------SSICQDG-DLPSAILDML-YLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEVDI----EKQSVHV 256
Cdd:cd04400      1 IFGSPLeeavelSSHKYNGrDLPSVVYRCIeYLDKNRAIYEEGIFRLSGSASVIKQLKERFNTEYDVDLfsssLYPDVHT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  257 VAWIFKDFLQNIEGSLMTSKLYDEWIAVTEK-VNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYH 335
Cdd:cd04400     81 VAGLLKLYLRELPTLILGGELHNDFKRLVEEnHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRN 160

                          170
                   ....*....|....
gi 1939401961  336 LsvglapCLLFVPS 349
Cdd:cd04400    161 V------CIVFSPT 168
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 214-377 1.96e-12

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 67.85  E-value: 1.96e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  214 LKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEVDI-EKQSVHVVAWIFKDFLQNIEGSLMTSKLYDEWIAvTEKVNDEE 292
Cdd:cd04376     20 LEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLdENHSVHDVAALLKEFFRDMPDPLLPRELYTAFIG-TALLEPDE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  293 KLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAV-----------NEMSSYHLSVGLAPCLL---------FVPSSCN 352
Cdd:cd04376     99 QLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADsidedgqevsgNKMTSLNLATIFGPNLLhkqksgereFVQASLR 178

                          170       180
                   ....*....|....*....|....*
gi 1939401961  353 NGMTNDIskkISLVKFMIENSPQFF 377
Cdd:cd04376    179 IEESTAI---INVVQTMIDNYEELF 200
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 195-375 2.78e-12

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 67.11  E-value: 2.78e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  195 SSICQDGDLPSAILDML-YLLKKEGptTKGVFIEPPSTTLFQTVKDKLDSGEEVDIEKQSVHVVAwIFKDFLQNIEGSLM 273
Cdd:cd04394     12 STVPEYGNVPKFLVDACtFLLDHLS--TEGLFRKSGSVVRQKELKAKLEGGEACLSSALPCDVAG-LLKQFFRELPEPLL 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  274 TSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLfvpsSCNN 353
Cdd:cd04394     89 PYDLHEALLKAQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFAPNLF----QSEE 164

                          170       180
                   ....*....|....*....|....*....
gi 1939401961  354 G---MTNDISKKISL----VKFMIENSPQ 375
Cdd:cd04394    165 GgekMSSSTEKRLRLqaavVQTLIDNASN 193
RA_RHG20 cd17115
Ras-associating (RA) domain found in Rho GTPase-activating protein 20 (RHG20) and similar ...
 25-139 8.65e-12

Ras-associating (RA) domain found in Rho GTPase-activating protein 20 (RHG20) and similar proteins; RHG20, also termed ARHGAP20, is one of GTPase activating proteins for Rho family proteins (RhoGAPs). It contains a PH-like domain, an RA domain, a RhoGap domain, and two Annexin-like (ANXL) repeats. RA domain has the beta-grasp ubiquitin-like fold with low sequence similarity to ubiquitin that is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair in eukaryotes.


Pssm-ID: 340635  Cd Length: 117  Bit Score: 63.12  E-value: 8.65e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961   25 EIPMQIFTEDIACCDTPLYVTATNFDTVNDIISKLLPMIR-KHNTEDYQLWFCPGPGKAPRLLQGHEYPHDIRMINIQKN 103
Cdd:cd17115      2 SIPLKVLNRDVGSCAYSKTLTVSNTDTAKDVIKMALQQFGiTGDPSDYQLWVKSGKEESPYPLIGHEYPFSIKMSHLRDA 81

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1939401961  104 FSSRDLRNFTAVPSLPGVIMKYLNADVHGKFILKPR 139
Cdd:cd17115     82 ARQSDGDNLNILDLDHLSSMENLPPEAQCQFILRPS 117
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 214-345 9.44e-12

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 65.17  E-value: 9.44e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  214 LKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEVDIEKQ--SVHVVAWIFKDFLQNIEGSLMTSKLYDEWIAVTEKVNDE 291
Cdd:cd04373     26 IEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKdfTVNAVAGALKSFFSELPDPLIPYSMHLELVEAAKINDRE 105

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1939401961  292 EKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLL 345
Cdd:cd04373    106 QRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWPTLM 159
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1074-1213 1.31e-11

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 65.05  E-value: 1.31e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1074 LRERIESEELIDW-NEEGILVIASVLKDFITNIEGSLLTSDLYE---SWLSVPDEgtlaGKINAIQRLLLKIPQANFILL 1149
Cdd:cd04404     57 VQQKYNMGEPVDFdQYEDVHLPAVILKTFLRELPEPLLTFDLYDdivGFLNVDKE----ERVERVKQLLQTLPEENYQVL 132

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1939401961 1150 KHLICVLVKIRD-SSMNNLDSNNLSVRIAPYVLWNQTPKDTLfgSDVSRKMSIIQIMIDNYSQIF 1213
Cdd:cd04404    133 KYLIKFLVQVSAhSDQNKMTNSNLAVVFGPNLLWAKDASMSL--SAINPINTFTKFLLDHQDEIF 195
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 218-377 2.25e-11

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 64.34  E-value: 2.25e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  218 GPTTKGVFIEPPSTTLFQTVKDKLDSG-EEVDIEK---QSVHVVAWIFKDFLQNIEGSLMTSKLYDEWIAVTEKVNDEEK 293
Cdd:cd04395     33 GLETVGIYRVPGNNAAISALQEELNRGgFDIDLQDprwRDVNVVSSLLKSFFRKLPEPLFTNELYPDFIEANRIEDPVER 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  294 LVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVPSSCNNGMTNDISKKISLVKFMIENS 373
Cdd:cd04395    113 LKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIVFGPTLVRTSDDNMETMVTHMPDQCKIVETLIQHY 192


                   ....
gi 1939401961  374 PQFF 377
Cdd:cd04395    193 DWFF 196
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 218-377 1.91e-10

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 61.76  E-value: 1.91e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  218 GPTTKGVFIEPPSTTLFQTVKDKLD-SGEEVDIEKQS---VHVVAWIFKDFLQNIEGSLMTSKLYDEWIAVTEKVNDEEK 293
Cdd:cd04372     31 GLQSEGLYRVSGFAEEIEDVKMAFDrDGEKADISATVypdINVITGALKLYFRDLPIPVITYDTYPKFIDAAKISNPDER 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  294 LVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVPSSCNNGMTNDISKKISLVKFMIENS 373
Cdd:cd04372    111 LEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPTLMRPPEDSALTTLNDMRYQILIVQLLITNE 190


                   ....
gi 1939401961  374 PQFF 377
Cdd:cd04372    191 DVLF 194
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 190-377 2.70e-10

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 61.27  E-value: 2.70e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  190 FGRELSSICQ-DGD-LPSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSG-EEVDIEKQS-----VHVVAWIF 261
Cdd:cd04398      1 FGVPLEDLILrEGDnVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDpLNVLLISPEdyesdIHSVASLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  262 KDFLQNIEGSLMTSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLA 341
Cdd:cd04398     81 KLFFRELPEPLLTKALSREFIEAAKIEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLAIIWG 160

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1939401961  342 PCLLFVPSscnnGMTNDISKKISLVKFMIENSPQFF 377
Cdd:cd04398    161 PTLMNAAP----DNAADMSFQSRVIETLLDNAYQIF 192
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 1028-1206 2.95e-10

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 60.91  E-value: 2.95e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1028 FGKNLTSIyVDSKLPAPIL--EMLSIIAEKGKESDQIFAIL-PENSHWSLRERIESE-ELIDWNEEGILVIASVLKDFIT 1103
Cdd:cd04377      1 FGVSLSSL-TSEDRSVPLVleKLLEHIEMHGLYTEGIYRKSgSANKIKELRQGLDTDpDSVNLEDYPIHVITSVLKQWLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1104 NIEGSLLTSDLYESWLSVPDEGTLAGKINAIQRLLLKIPQANFILLKHLICVLVKIRD-SSMNNLDSNNLSVRIAPYVLW 1182
Cdd:cd04377     80 ELPEPLMTFELYENFLRAMELEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALqEEVNRMSANALAIVFAPCILR 159

                          170       180
                   ....*....|....*....|....*
gi 1939401961 1183 NQTPKDTLFG-SDVSRKMSIIQIMI 1206
Cdd:cd04377    160 CPDTADPLQSlQDVSKTTTCVETLI 184
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 477-655 3.06e-10

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 60.91  E-value: 3.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  477 FGKSLTSLF-EDKKLPTPILDMLSIIAEKGHESDHIFK---ILPKEShwSLRYRLDSE-QHIDWDEECVLVIASVLKDFI 551
Cdd:cd04377      1 FGVSLSSLTsEDRSVPLVLEKLLEHIEMHGLYTEGIYRksgSANKIK--ELRQGLDTDpDSVNLEDYPIHVITSVLKQWL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  552 INIDGSLLTLEFYENWL---SIPDEGtlaEKINAIQSLLQQIPEPNFILLKHLVYVLVIIKD-SSMNNLDSYRLSLRIAP 627
Cdd:cd04377     79 RELPEPLMTFELYENFLramELEEKQ---ERVRALYSVLEQLPRANLNTLERLIFHLVRVALqEEVNRMSANALAIVFAP 155

                          170       180
                   ....*....|....*....|....*....
gi 1939401961  628 HVLWGKTSRDSLFG-TDVLRKLSIMQIMI 655
Cdd:cd04377    156 CILRCPDTADPLQSlQDVSKTTTCVETLI 184
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 818-938 3.98e-10

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 60.93  E-value: 3.98e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  818 VIASVLKDFITHIDGSLLTCELYESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVLVII-KDSSTNKLDTNR 896
Cdd:cd04386     76 AVASALKSYLRELPDPLLTYNLYEDWVQAANKPDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLaQKSDENKMSPSN 155

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1939401961  897 LSLRLGPHLLWGWTSSDAFFGK--NVSRKLSIIQIMIDNYHQIF 938
Cdd:cd04386    156 IAIVLAPNLLWAKNEGSLAEMAagTSVHVVAIVELIISHADWFF 199
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 235-354 5.68e-10

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 60.21  E-value: 5.68e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  235 QTVKDKLDSGEEVDIEK----QSVHVVAWIFKDFLQNIEGSLMTSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAA 310
Cdd:cd04384     49 QRLRHEFDSEQIPDLTKdvyiQDIHSVSSLCKLYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYR 128

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1939401961  311 LLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVP---SSCNNG 354
Cdd:cd04384    129 TLEFLMRHLSRLAKYCSITNMHAKNLAIVWAPNLLRSKqieSACFSG 175
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1093-1213 5.97e-10

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 60.55  E-value: 5.97e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1093 VIASVLKDFITNIEGSLLTSDLYESWLSVPDEGTLAGKINAIQRLLLKIPQANFILLKHLICVLVKI-RDSSMNNLDSNN 1171
Cdd:cd04386     76 AVASALKSYLRELPDPLLTYNLYEDWVQAANKPDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLaQKSDENKMSPSN 155

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1939401961 1172 LSVRIAPYVLWNQTPKDTLFGSDVSRK--MSIIQIMIDNYSQIF 1213
Cdd:cd04386    156 IAIVLAPNLLWAKNEGSLAEMAAGTSVhvVAIVELIISHADWFF 199
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 190-345 7.04e-10

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 59.71  E-value: 7.04e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  190 FGRELSSICQ--DGDLPSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEVDI---EKQSVHVVAWIFKDF 264
Cdd:cd04403      1 FGCHLEALCQreNSTVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLddsKWEDIHVITGALKLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  265 LQNIEGSLMTSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCL 344
Cdd:cd04403     81 FRELPEPLFPYSLFNDFVAAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPTL 160


                   .
gi 1939401961  345 L 345
Cdd:cd04403    161 L 161
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 819-938 1.92e-09

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 59.01  E-value: 1.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  819 IASVLKDFITHIDGSLLTCELYESWLSVPD------EGTLA------EQINAIQRLLQKIPEPNFILLKHLICVL-VIIK 885
Cdd:cd04392     64 CATVLKGFLGELPEPLLTHAHYPAHLQIADlcqfdeKGNKTsapdkeRLLEALQLLLLLLPEENRNLLKLILDLLyQTAK 143

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1939401961  886 DSSTNKLDTNRLSLRLGPHLLWGWTSSDAFFGKNVSRKLSIIQIMIDNYHQIF 938
Cdd:cd04392    144 HEDKNKMSADNLALLFTPHLICPRNLTPEDLHENAQKLNSIVTFMIKHSQKLF 196
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 536-662 1.96e-09

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 58.50  E-value: 1.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  536 DEECVLVIASVLKDFIINIDGSLLTLEFYE---NWLSIPDEgtlaEKINAIQSLLQQIPEPNFILLKHLVYVLVIIKD-S 611
Cdd:cd04404     71 QYEDVHLPAVILKTFLRELPEPLLTFDLYDdivGFLNVDKE----ERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAhS 146

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1939401961  612 SMNNLDSYRLSLRIAPHVLWGKTSRDSLFGTDVLRklSIMQIMIDNYHEIF 662
Cdd:cd04404    147 DQNKMTNSNLAVVFGPNLLWAKDASMSLSAINPIN--TFTKFLLDHQDEIF 195
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 812-934 2.24e-09

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 58.09  E-value: 2.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  812 NEERVLVIASVLKDFITHIDGSLLTCELYESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLK----HLICVLviiKDS 887
Cdd:cd04385     65 GEYTVHDVADVLKRFLRDLPDPLLTSELHAEWIEAAELENKDERIARYKELIRRLPPINRATLKvligHLYRVQ---KHS 141

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1939401961  888 STNKLDTNRLSLRLGPHLLwgwtSSDAFFGKNVSRKLSIIQIMIDNY 934
Cdd:cd04385    142 DENQMSVHNLALVFGPTLF----QTDEHSVGQTSHEVKVIEDLIDNY 184
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1074-1213 2.93e-09

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 58.63  E-value: 2.93e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1074 LRERIESEELIDWNEEGILV--IASVLKDFITNIEGSLLTSDLYESWLSVPD------EGTLAG------KINAIQRLLL 1139
Cdd:cd04392     42 LRDLLNSGTDLDLESGGFHAhdCATVLKGFLGELPEPLLTHAHYPAHLQIADlcqfdeKGNKTSapdkerLLEALQLLLL 121

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1939401961 1140 KIPQANFILLKHLICVLVK-IRDSSMNNLDSNNLSVRIAPYVLW--NQTPKDTlfgSDVSRKM-SIIQIMIDNYSQIF 1213
Cdd:cd04392    122 LLPEENRNLLKLILDLLYQtAKHEDKNKMSADNLALLFTPHLICprNLTPEDL---HENAQKLnSIVTFMIKHSQKLF 196
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 543-662 3.50e-09

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 58.24  E-value: 3.50e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  543 IASVLKDFIINIDGSLLTLEFYENWLSIPDEGTLAEK------------INAIQSLLQQIPEPNFILLKHLVYVL-VIIK 609
Cdd:cd04392     64 CATVLKGFLGELPEPLLTHAHYPAHLQIADLCQFDEKgnktsapdkerlLEALQLLLLLLPEENRNLLKLILDLLyQTAK 143

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1939401961  610 DSSMNNLDSYRLSLRIAPHVLWGKTSRDSLFGTDVLRKLSIMQIMIDNYHEIF 662
Cdd:cd04392    144 HEDKNKMSADNLALLFTPHLICPRNLTPEDLHENAQKLNSIVTFMIKHSQKLF 196
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 214-345 7.27e-09

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 57.07  E-value: 7.27e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  214 LKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEVDIEKQS-VHVVAWIFKDFLQNIEGSLMTSKLYDEWIAVTEKVN-DE 291
Cdd:cd04390     33 IREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTdVHTVASLLKLYLRELPEPVIPWAQYEDFLSCAQLLSkDE 112

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1939401961  292 EK-LVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLL 345
Cdd:cd04390    113 EKgLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNIL 167
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 819-938 7.65e-09

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 57.07  E-value: 7.65e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  819 IASVLKDFITHIDGSLLTCELYESWLsvpdeGTL----AEQINAIQRLLQKIPEPN----FILLKHLICVLVIIKDS--- 887
Cdd:cd04376     64 VAALLKEFFRDMPDPLLPRELYTAFI-----GTAllepDEQLEALQLLIYLLPPCNcdtlHRLLKFLHTVAEHAADSide 138

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1939401961  888 -----STNKLDTNRLSLRLGPHLLWGWTSSDAFFGKNVSR------KLSIIQIMIDNYHQIF 938
Cdd:cd04376    139 dgqevSGNKMTSLNLATIFGPNLLHKQKSGEREFVQASLRieestaIINVVQTMIDNYEELF 200
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 245-372 1.18e-08

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 56.36  E-value: 1.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  245 EEVDIEKQSVHVVAWIFKDFLQNIEGSLMTSKLYDEWIAV-------TEKVNDEEKLV--AVQS---LLDKMPPENAALL 312
Cdd:cd04408     59 DLVDLSGHSPHDITSVLKHFLKELPEPVLPFQLYDDFIALakelqrdSEKAAESPSIVenIIRSlkeLLGRLPVSNYNTL 138

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1939401961  313 RQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVPSSCNNGMTN--DISKKISLVKFMIEN 372
Cdd:cd04408    139 RHLMAHLYRVAERFEDNKMSPNNLGIVFGPTLLRPLVGGDVSMICllDTGYQAQLVEFLISN 200
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 811-938 1.60e-08

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 55.87  E-value: 1.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  811 WNEerVLVIASVLKDFITHIDGSLLTCELYESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVLVIIKDSS-T 889
Cdd:cd04395     70 WRD--VNVVSSLLKSFFRKLPEPLFTNELYPDFIEANRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSeV 147

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1939401961  890 NKLDTNRLSLRLGPHLLWGWTSSDAFFGKNVSRKLSIIQIMIDNYHQIF 938
Cdd:cd04395    148 NKMEPRNLAIVFGPTLVRTSDDNMETMVTHMPDQCKIVETLIQHYDWFF 196
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1050-1213 1.88e-08

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 55.87  E-value: 1.88e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1050 SIIAEKGKESDQIFAIlPENS------HWSLRERIESEELIDWNEEGILVIASVLKDFITNIEGSLLTSDLYESWLSVPD 1123
Cdd:cd04395     27 NIVEARGLETVGIYRV-PGNNaaisalQEELNRGGFDIDLQDPRWRDVNVVSSLLKSFFRKLPEPLFTNELYPDFIEANR 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1124 EGTLAGKINAIQRLLLKIPQANFILLKHLICVLVKIRDSS-MNNLDSNNLSVRIAPYVLwnQTPKDTL--FGSDVSRKMS 1200
Cdd:cd04395    106 IEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSeVNKMEPRNLAIVFGPTLV--RTSDDNMetMVTHMPDQCK 183

                          170
                   ....*....|...
gi 1939401961 1201 IIQIMIDNYSQIF 1213
Cdd:cd04395    184 IVETLIQHYDWFF 196
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 474-662 1.90e-08

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 55.93  E-value: 1.90e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  474 KCLFGKSLTSLFE--DKKLPTPILDMLSIIAEKGHESDHIFKILPKESHWS-LRYRLDSEQ-HIDWDEEC--VLVIASVL 547
Cdd:cd04386      2 KPVFGTPLEEHLKrtGREIALPIEACVMCLLETGMNEEGLFRVGGGASKLKrLKAALDAGTfSLPLDEFYsdPHAVASAL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  548 KDFIINIDGSLLTLEFYENWL---SIPDEgtlAEKINAIQSLLQQIPEPNFILLKHLVYVLVII-KDSSMNNLDSYRLSL 623
Cdd:cd04386     82 KSYLRELPDPLLTYNLYEDWVqaaNKPDE---DERLQAIWRILNKLPRENRDNLRYLIKFLSKLaQKSDENKMSPSNIAI 158

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1939401961  624 RIAPHVLWGKTSRDSLFGTD--VLRKLSIMQIMIDNYHEIF 662
Cdd:cd04386    159 VLAPNLLWAKNEGSLAEMAAgtSVHVVAIVELIISHADWFF 199
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1094-1213 4.86e-08

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 54.75  E-value: 4.86e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1094 IASVLKDFITNIEGSLLTSDLYESWLSV----PDEgtlagKINAIQRLLLKIPQAN----FILLKHLICVLVKIRDS--- 1162
Cdd:cd04376     64 VAALLKEFFRDMPDPLLPRELYTAFIGTallePDE-----QLEALQLLIYLLPPCNcdtlHRLLKFLHTVAEHAADSide 138

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1939401961 1163 -----SMNNLDSNNLSVRIAPYVLWNQTPKDTLFGSDVSR------KMSIIQIMIDNYSQIF 1213
Cdd:cd04376    139 dgqevSGNKMTSLNLATIFGPNLLHKQKSGEREFVQASLRieestaIINVVQTMIDNYEELF 200
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 203-376 2.06e-07

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 53.14  E-value: 2.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  203 LPSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSG--EEVDIEKQSVHVVAWIFKDFLQNIEGSLMTSKLYDE 280
Cdd:cd04397     27 IPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNptEVPDLSKENPVQLAALLKKFLRELPDPLLTFKLYRL 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  281 WIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNE-----MSSYHLSVGLAPCLLFvPSSCNNGM 355
Cdd:cd04397    107 WISSQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFSHIDEetgskMDIHNLATVITPNILY-SKTDNPNT 185

                          170       180
                   ....*....|....*....|.
gi 1939401961  356 TNDISKKISLVKFMIENSPQF 376
Cdd:cd04397    186 GDEYFLAIEAVNYLIENNEEF 206
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 1087-1209 5.31e-07

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 51.15  E-value: 5.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1087 NEEGILVIASVLKDFITNIEGSLLTSDLYESWLSVPDEGTLAGKINAIQRLLLKIPQANFILLKHLICVLVKIRD-SSMN 1165
Cdd:cd04385     65 GEYTVHDVADVLKRFLRDLPDPLLTSELHAEWIEAAELENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKhSDEN 144

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1939401961 1166 NLDSNNLSVRIAPYVLwnQTpKDTLFGSDvSRKMSIIQIMIDNY 1209
Cdd:cd04385    145 QMSVHNLALVFGPTLF--QT-DEHSVGQT-SHEVKVIEDLIDNY 184
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 1094-1208 8.84e-07

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 50.85  E-value: 8.84e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1094 IASVLKDFITNIEGSLLTSDLYESWLSVPDEGTLAGKINAIQRLLLKIPQANFILLKHLICVLVKIRDSSMNNLDS-NNL 1172
Cdd:cd04374     89 ITSALKTYLRNLPEPLMTYELHNDFINAAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTvSNL 168

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1939401961 1173 SVRIAPYVLWNQtpKDTlfgsdVSRKMSI------IQIMIDN 1208
Cdd:cd04374    169 GVVFGPTLLRPQ--EET-----VAAIMDIkfqnivVEILIEN 203
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 245-372 9.00e-07

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 50.88  E-value: 9.00e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  245 EEVDIEKQSVHVVAWIFKDFLQNIEGSLMTSKLYDEWIAV---TEKVNDEEK-----------LVAVQSLLDKMPPENAA 310
Cdd:cd04378     59 DLVELSELSPHDISSVLKLFLRQLPEPLILFRLYNDFIALakeIQRDTEEDKapntpievnriIRKLKDLLRQLPASNYN 138

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1939401961  311 LLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLF-------VPSSCnngmTNDISKKISLVKFMIEN 372
Cdd:cd04378    139 TLQHLIAHLYRVAEQFEENKMSPNNLGIVFGPTLIRprpgdadVSLSS----LVDYGYQARLVEFLITN 203
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 523-656 1.09e-06

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 50.58  E-value: 1.09e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  523 LRYRLDSEQHIDWDEECVL----VIASVLKDFIINIDGSLLTLEFYENWLSIPDEGTLAEKINAIQSLLQQIPEPNFILL 598
Cdd:cd04384     51 LRHEFDSEQIPDLTKDVYIqdihSVSSLCKLYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTL 130

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  599 KHLVYVLVIIKDS-SMNNLDSYRLSLRIAPHVLWGKTSRDSLF-GTDVLRKLSIMQIMID 656
Cdd:cd04384    131 EFLMRHLSRLAKYcSITNMHAKNLAIVWAPNLLRSKQIESACFsGTAAFMEVRIQSVVVE 190
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 819-906 1.13e-06

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 50.85  E-value: 1.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  819 IASVLKDFITHIDGSLLTCELYESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVLVIIKD-SSTNKLDTNRL 897
Cdd:cd04374     89 ITSALKTYLRNLPEPLMTYELHNDFINAAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDhSKKNLMTVSNL 168


                   ....*....
gi 1939401961  898 SLRLGPHLL 906
Cdd:cd04374    169 GVVFGPTLL 177
RA cd17043
Ras-associating (RA) domain, structurally similar to a beta-grasp ubiquitin-like fold; RA ...
 27-97 1.41e-06

Ras-associating (RA) domain, structurally similar to a beta-grasp ubiquitin-like fold; RA domain-containing proteins function by interacting with Ras proteins directly or indirectly and are involved in various functions ranging from tumor suppression to being oncoproteins. Ras proteins are small GTPases that are involved in cellular signal transduction. The RA domain has the beta-grasp ubiquitin-like (Ubl) fold with low sequence similarity to ubiquitin (Ub); Ub is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. RA-containing proteins include RalGDS, AF6, RIN, RASSF1, SNX27, CYR1, STE50, and phospholipase C epsilon.


Pssm-ID: 340563  Cd Length: 87  Bit Score: 47.31  E-value: 1.41e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1939401961   27 PMQIFTEDIACCDTPLYVTATNFDTVNDIISKLLPMI-RKHNTEDYQLWFCPGPGKAPRLLQGHEYPHDIRM 97
Cdd:cd17043      1 VLKVYDDDLAPGSAYKSILVSSTTTAREVVQLLLEKYgLEEDPEDYSLYEVSEKQETERVLHDDECPLLIQL 72
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 1082-1196 1.46e-06

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 50.20  E-value: 1.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1082 ELIDWNEEGILVIASVLKDFITNIEGSLLTSDLYESWLSVPDE------------GTLAGKINAIQRLLLKIPQANFILL 1149
Cdd:cd04408     59 DLVDLSGHSPHDITSVLKHFLKELPEPVLPFQLYDDFIALAKElqrdsekaaespSIVENIIRSLKELLGRLPVSNYNTL 138

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1939401961 1150 KHLICVLVKIRDSSMNN-LDSNNLSVRIAPYVLwnqtpkDTLFGSDVS 1196
Cdd:cd04408    139 RHLMAHLYRVAERFEDNkMSPNNLGIVFGPTLL------RPLVGGDVS 180
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 753-905 1.57e-06

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 49.74  E-value: 1.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  753 FGQPL------TSIFEDKKIPTPIFDMLSIIAEKGKDTDHIFK---TLSEYSHwsLRDKIDTYQYINWNEERVLVIASVL 823
Cdd:cd04381      1 FGASLslaverSRCHDGIDLPLVFRECIDYVEKHGMKCEGIYKvsgIKSKVDE--LKAAYNRRESPNLEEYEPPTVASLL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  824 KDFITHIDGSLLTCELYESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVL--VIIKDsSTNKLDTNRLSLRL 901
Cdd:cd04381     79 KQYLRELPEPLLTKELMPRFEEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMdhVIAQE-LETKMNIQNISIVL 157


                   ....
gi 1939401961  902 GPHL 905
Cdd:cd04381    158 SPTV 161
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 188-363 2.72e-06

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 49.34  E-value: 2.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  188 KLFGRELSSICQDG--DLPSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEVDIEKQSVH---VVAWIFK 262
Cdd:cd04383      1 KLFNGSLEEYIQDSgqAIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEDPLADDQNDHdinSVAGVLK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  263 DFLQNIEGSLMTSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAP 342
Cdd:cd04383     81 LYFRGLENPLFPKERFEDLMSCVKLENPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGP 160

                          170       180
                   ....*....|....*....|....*.
gi 1939401961  343 CLLFVPS-----SCNNgMTNDISKKI 363
Cdd:cd04383    161 TLMPVPEgqdqvSCQA-HVNELIKTI 185
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 523-662 3.64e-06

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 49.36  E-value: 3.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  523 LRYRLDSEQHIDWDEE-CVLVIASVLKDFIINIDGSLLTLEFYENWLsipdeGTL----AEKINAIQSLLQQIPEPN--- 594
Cdd:cd04376     43 LREEFDRGIDVVLDENhSVHDVAALLKEFFRDMPDPLLPRELYTAFI-----GTAllepDEQLEALQLLIYLLPPCNcdt 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  595 -FILLKHLVYVLVIIKDS--------SMNNLDSYRLSLRIAPHVLWGKTSRDSLFGTDVLR------KLSIMQIMIDNYH 659
Cdd:cd04376    118 lHRLLKFLHTVAEHAADSidedgqevSGNKMTSLNLATIFGPNLLHKQKSGEREFVQASLRieestaIINVVQTMIDNYE 197


                   ...
gi 1939401961  660 EIF 662
Cdd:cd04376    198 ELF 200
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 534-604 3.76e-06

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 49.31  E-value: 3.76e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1939401961  534 DWDeecVLVIASVLKDFIINIDGSLLTLEFYENWLSIPDEGTLAEKINAIQSLLQQIPEPNF----ILLKHLVYV 604
Cdd:cd04374     83 EWE---IKTITSALKTYLRNLPEPLMTYELHNDFINAAKSENLESRVNAIHSLVHKLPEKNRemleLLIKHLTNV 154
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 819-913 4.58e-06

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 49.04  E-value: 4.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  819 IASVLKDFITHIDGSLLTCELYESWLSVPDE------------GTLAEQINAIQRLLQKIPEPNFILLKHLICVLVIIKD 886
Cdd:cd04408     71 ITSVLKHFLKELPEPVLPFQLYDDFIALAKElqrdsekaaespSIVENIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAE 150

                           90       100
                   ....*....|....*....|....*...
gi 1939401961  887 S-STNKLDTNRLSLRLGPHLLWGWTSSD 913
Cdd:cd04408    151 RfEDNKMSPNNLGIVFGPTLLRPLVGGD 178
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 213-372 6.18e-06

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 48.16  E-value: 6.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  213 LLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEVDIEKQSVHVVAWIFKDFLQNIEGSLMTSKLYDEWIavtEKVNDEE 292
Cdd:cd04389     32 VLALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPLSGLEDPHVPASLLKLWLRELEEPLIPDALYQQCI---SASEDPD 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  293 KLVAVqslLDKMPPENAALLRQLFRILYE--IKNNSAVNEMSSYHLSVGLAPCLLFVPSSCNNGMTNDISKKISLVKFMI 370
Cdd:cd04389    109 KAVEI---VQKLPIINRLVLCYLINFLQVfaQPENVAHTKMDVSNLAMVFAPNILRCTSDDPRVIFENTRKEMSFLRTLI 185


                   ..
gi 1939401961  371 EN 372
Cdd:cd04389    186 EH 187
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 819-931 6.29e-06

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 48.06  E-value: 6.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  819 IASVLKDFITHIDGSLLTCELYESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVLV-IIKDSSTNKLDTNRL 897
Cdd:cd04407     70 ITGLLKQWLRELPEPLMTFAQYNDFLRAVELPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVkVALEEDVNRMSPNAL 149

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1939401961  898 SLRLGPHLLWGWTSSDAFFG-KNVSRKLSIIQIMI 931
Cdd:cd04407    150 AIVFAPCLLRCPDSSDPLTSmKDVAKTTTCVEMLI 184
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 190-344 6.78e-06

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 48.20  E-value: 6.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  190 FGRELS-----SICQDG-DLPSAILDMLYLLKKEGPTTKGVFIEPPSTTLFQTVKDKLDSGEEVDIEKQSVHVVAWIFKD 263
Cdd:cd04381      1 FGASLSlaverSRCHDGiDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEYEPPTVASLLKQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  264 FLQNIEGSLMTSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPC 343
Cdd:cd04381     81 YLRELPEPLLTKELMPRFEEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIVLSPT 160


                   .
gi 1939401961  344 L 344
Cdd:cd04381    161 V 161
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 477-614 7.31e-06

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 47.82  E-value: 7.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  477 FGKSL------TSLFEDKKLPTPILDMLSIIAEKGHESDHIFKILPKESHW-SLRYRLDSEQHIDWDEECVLVIASVLKD 549
Cdd:cd04381      1 FGASLslaverSRCHDGIDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVdELKAAYNRRESPNLEEYEPPTVASLLKQ 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1939401961  550 FIINIDGSLLTLEF---YENWLSIPDEgtlAEKINAIQSLLQQIPEPNFILLK----HLVYVLVIIKDSSMN 614
Cdd:cd04381     81 YLRELPEPLLTKELmprFEEACGRPTE---AEREQELQRLLKELPECNRLLLAwlivHMDHVIAQELETKMN 149
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 753-931 7.40e-06

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 48.07  E-value: 7.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  753 FGQPLTSIF-EDKKIPTPIFDMLSIIAEKGKDTDHIF-KTLSEYSHWSLRDKIDT-YQYINWNEERVLVIASVLKDFITH 829
Cdd:cd04406      1 FGVELSRLTsEDRSVPLVVEKLINYIEMHGLYTEGIYrKSGSTNKIKELRQGLDTdANSVNLDDYNIHVIASVFKQWLRD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  830 IDGSLLTCELYESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVLVIIK-DSSTNKLDTNRLSLRLGPHLLWG 908
Cdd:cd04406     81 LPNPLMTFELYEEFLRAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIAlQEETNRMSANALAIVFAPCILRC 160

                          170       180
                   ....*....|....*....|....
gi 1939401961  909 WTSSDAFFG-KNVSRKLSIIQIMI 931
Cdd:cd04406    161 PDTTDPLQSvQDISKTTTCVELIV 184
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 752-905 7.68e-06

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 48.50  E-value: 7.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  752 LFGQPLTSIFED--KKIP---TPIF--DMLSIIAEKGKDTDHIF-----KTLSEyshwSLRDKIDTYQY---INWNEERV 816
Cdd:cd04391      1 LFGVPLSTLLERdqKKVPgskVPLIfqKLINKLEERGLETEGILripgsAQRVK----FLCQELEAKFYegtFLWDQVKQ 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  817 LVIASVLKDFITHIDGSLLTCELYESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVL-VIIKDSSTNKLDTN 895
Cdd:cd04391     77 HDAASLLKLFIRELPQPLLTVEYLPAFYSVQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLqKVVDHEEKNKMNLW 156

                          170
                   ....*....|
gi 1939401961  896 RLSLRLGPHL 905
Cdd:cd04391    157 NVAMIMAPNL 166
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1073-1178 8.16e-06

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 48.57  E-value: 8.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1073 SLRERIESE-ELIDWNEEGILVIASVLKDFITNIEGSLLTSDLYESWLS----VPDEGtlagKINAIQRLLLKIPQANFI 1147
Cdd:cd04375     53 KLRSMIESStDNVNYDGQQAYDVADMLKQYFRDLPEPLLTNKLSETFIAifqyVPKEQ----RLEAVQCAILLLPDENRE 128

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1939401961 1148 LLKHLICVLVKI-RDSSMNNLDSNNLSVRIAP 1178
Cdd:cd04375    129 VLQTLLYFLSDVaANSQENQMTATNLAVCLAP 160
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 262-345 1.27e-05

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 47.39  E-value: 1.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  262 KDFLQNIEGSLMTSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLA 341
Cdd:cd04374     94 KTYLRNLPEPLMTYELHNDFINAAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFG 173


                   ....
gi 1939401961  342 PCLL 345
Cdd:cd04374    174 PTLL 177
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 1074-1216 1.53e-05

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 46.97  E-value: 1.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1074 LRERIESE---ELIDWNEE-GILVIASVLKDFITNIEGSLLTSDLYESWLSVPDE-GTLAGKINAIQRLLLKIPQANFIL 1148
Cdd:cd04400     57 LKERFNTEydvDLFSSSLYpDVHTVAGLLKLYLRELPTLILGGELHNDFKRLVEEnHDRSQRALELKDLVSQLPQANYDL 136

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1939401961 1149 LKHLICVLVKIrdssMNNLDSNNLSVRIAPYVlwnqtpkdtlFGSDVSRKMSIIQIMIDNYSQIFGND 1216
Cdd:cd04400    137 LYVLFSFLRKI----IEHSDVNKMNLRNVCIV----------FSPTLNIPAGIFVLFLTDFDCIFGGI 190
RA pfam00788
Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); ...
 28-97 1.54e-05

Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.


Pssm-ID: 425871  Cd Length: 93  Bit Score: 44.63  E-value: 1.54e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1939401961   28 MQIFTEDIACCDTPLYVTATNFDTVNDIISKLLPMIR-KHNTEDYQLWFCPGPGKAPRLLQGHEYPHDIRM 97
Cdd:pfam00788    5 LKVYTEDGKPGTTYKTILVSSSTTAEEVIEALLEKFGlEDDPRDYVLVEVLERGGGERRLPDDECPLQIQL 75
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 1028-1206 2.19e-05

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 46.52  E-value: 2.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1028 FGKNLTSIyVDSKLPAPIL--EMLSIIAEKGKESDQIFAIL-PENSHWSLRERIESE-ELIDWNEEGILVIASVLKDFIT 1103
Cdd:cd04407      1 FGVRVGSL-TSNKTSVPIVleKLLEHVEMHGLYTEGIYRKSgSANRMKELHQLLQADpENVKLENYPIHAITGLLKQWLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1104 NIEGSLLTSDLYESWLSVPDEGTLAGKINAIQRLLLKIPQANFILLKHLICVLVKI-RDSSMNNLDSNNLSVRIAPYVLW 1182
Cdd:cd04407     80 ELPEPLMTFAQYNDFLRAVELPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVaLEEDVNRMSPNALAIVFAPCLLR 159

                          170       180
                   ....*....|....*....|....*
gi 1939401961 1183 NQTPKDTLFG-SDVSRKMSIIQIMI 1206
Cdd:cd04407    160 CPDSSDPLTSmKDVAKTTTCVEMLI 184
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 532-658 3.03e-05

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 46.15  E-value: 3.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  532 HIDWDEECVLVIASVLKDFIINIDGSLLTLEFYENWLSIPDEGTLAEKINAIQSLLQQIPEPNFILLKHLVYVLVII-KD 610
Cdd:cd04385     61 QLREGEYTVHDVADVLKRFLRDLPDPLLTSELHAEWIEAAELENKDERIARYKELIRRLPPINRATLKVLIGHLYRVqKH 140

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1939401961  611 SSMNNLDSYRLSLRIAPhvlwgktsrdSLFGTDVL------RKLSIMQIMIDNY 658
Cdd:cd04385    141 SDENQMSVHNLALVFGP----------TLFQTDEHsvgqtsHEVKVIEDLIDNY 184
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 819-906 4.37e-05

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 45.88  E-value: 4.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  819 IASVLKDFITHIDGSLLTCELYESWLSVPDE--------------GTLAEQINAIQRLLQKIPEPNFILLKHLICVLVII 884
Cdd:cd04378     71 ISSVLKLFLRQLPEPLILFRLYNDFIALAKEiqrdteedkapntpIEVNRIIRKLKDLLRQLPASNYNTLQHLIAHLYRV 150

                           90       100
                   ....*....|....*....|...
gi 1939401961  885 KDSST-NKLDTNRLSLRLGPHLL 906
Cdd:cd04378    151 AEQFEeNKMSPNNLGIVFGPTLI 173
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1073-1212 4.71e-05

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 45.93  E-value: 4.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1073 SLRERIESEELIDWNEEgILVIASVLKDFITNIEGSLLTSDLYESWLSVPDEGTLAGKINAIQRLLLKIPQANFILLKHL 1152
Cdd:cd04394     52 ELKAKLEGGEACLSSAL-PCDVAGLLKQFFRELPEPLLPYDLHEALLKAQELPTDEERKSATLLLTCLLPDEHVNTLRYF 130

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1939401961 1153 ICVL--VKIRdSSMNNLDSNNLSVRIAPyVLWNQTPKDTLFGSDVSRKM----SIIQIMIDNYSQI 1212
Cdd:cd04394    131 FSFLydVAQR-CSENKMDSSNLAVIFAP-NLFQSEEGGEKMSSSTEKRLrlqaAVVQTLIDNASNI 194
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 224-376 4.74e-05

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 46.25  E-value: 4.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  224 VFIEPPsttlfqtvkdklDSGEEVDIEKQSVHVVAWIFKDFLQNIEGSLMTSKLYDEWIAVTEK--------------VN 289
Cdd:cd04396     69 IFSTPP------------DYGKSFDWDGYTVHDAASVLRRYLNNLPEPLVPLDLYEEFRNPLRKrprilqymkgrinePL 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  290 DEEKLVAV---QSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVPSSCNNGMTNDISKkiSLV 366
Cdd:cd04396    137 NTDIDQAIkeyRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGILSHPDHEMDPKEYKLSR--LVV 214

                          170
                   ....*....|
gi 1939401961  367 KFMIENSPQF 376
Cdd:cd04396    215 EFLIEHQDKF 224
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 477-639 5.92e-05

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 45.38  E-value: 5.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  477 FGKSLTSLF-EDKKLPTPILDMLSIIAEKGHESDHIFKILPKESHW-SLRYRLDSE-QHIDWDEECVLVIASVLKDFIIN 553
Cdd:cd04406      1 FGVELSRLTsEDRSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIkELRQGLDTDaNSVNLDDYNIHVIASVFKQWLRD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  554 IDGSLLTLEFYENWLSIPDEGTLAEKINAIQSLLQQIPEPNFILLKHLVYVLVIIK-DSSMNNLDSYRLSLRIAPHVLWG 632
Cdd:cd04406     81 LPNPLMTFELYEEFLRAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIAlQEETNRMSANALAIVFAPCILRC 160


                   ....*..
gi 1939401961  633 KTSRDSL 639
Cdd:cd04406    161 PDTTDPL 167
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 476-627 1.06e-04

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 45.03  E-value: 1.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  476 LFGKSLTSLFE-DKKLPTPIL------DMLSIIAEKGHESDHIFKIlP--KESHWSLRYRLDS---EQHIDWDEECVLVI 543
Cdd:cd04391      1 LFGVPLSTLLErDQKKVPGSKvplifqKLINKLEERGLETEGILRI-PgsAQRVKFLCQELEAkfyEGTFLWDQVKQHDA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  544 ASVLKDFIINIDGSLLTLEFYENWLSIPDEGTLAEKINAIQSLLQQIPEPNFILLKHLV-YVLVIIKDSSMNNLDSYRLS 622
Cdd:cd04391     80 ASLLKLFIRELPQPLLTVEYLPAFYSVQGLPSKKDQLQALNLLVLLLPEANRDTLKALLeFLQKVVDHEEKNKMNLWNVA 159


                   ....*
gi 1939401961  623 LRIAP 627
Cdd:cd04391    160 MIMAP 164
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 477-630 1.41e-04

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 44.30  E-value: 1.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  477 FGKSLTSLFEDKKLPTPILDMLSI--IAEKGHESDHIFKI------LPKeshwsLRYRLDSEQHIDWDE---ECVLVIAS 545
Cdd:cd04403      1 FGCHLEALCQRENSTVPKFVRLCIeaVEKRGLDVDGIYRVsgnlavIQK-----LRFAVDHDEKLDLDDskwEDIHVITG 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  546 VLKDFIINIDGSLLTLEFYENWLSIPDEGTLAEKINAIQSLLQQIPEPNF----ILLKHLVYVlviIKDSSMNNLDSYRL 621
Cdd:cd04403     76 ALKLFFRELPEPLFPYSLFNDFVAAIKLSDYEQRVSAVKDLIKSLPKPNHdtlkMLFRHLCRV---IEHGEKNRMTTQNL 152


                   ....*....
gi 1939401961  622 SLRIAPHVL 630
Cdd:cd04403    153 AIVFGPTLL 161
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1074-1181 1.54e-04

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 44.42  E-value: 1.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1074 LRERIESEELIDWNEEG----ILVIASVLKDFITNIEGSLLTSDLYESWLSVPDEGTLAGKINAIQRLLLKIPQANFILL 1149
Cdd:cd04384     51 LRHEFDSEQIPDLTKDVyiqdIHSVSSLCKLYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTL 130

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1939401961 1150 KHLICVLVKIRDS-SMNNLDSNNLSVRIAPYVL 1181
Cdd:cd04384    131 EFLMRHLSRLAKYcSITNMHAKNLAIVWAPNLL 163
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 1094-1196 4.49e-04

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 42.80  E-value: 4.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1094 IASVLKDFITNIEGSLLTSDLYESWLSVPDE--------------GTLAGKINAIQRLLLKIPQANFILLKHLICVLVKI 1159
Cdd:cd04378     71 ISSVLKLFLRQLPEPLILFRLYNDFIALAKEiqrdteedkapntpIEVNRIIRKLKDLLRQLPASNYNTLQHLIAHLYRV 150

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1939401961 1160 RDSSMNN-LDSNNLSVRIAPYVLwnqTPKDTlfGSDVS 1196
Cdd:cd04378    151 AEQFEENkMSPNNLGIVFGPTLI---RPRPG--DADVS 183
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 776-933 4.65e-04

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 42.76  E-value: 4.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  776 IIAEKGKDTDHIFKTLSEYSHW-SLRDKIDTYQYINWNEERVLVIASVLKDFITHIDGSLLTCELYESWLSVPDEGTlae 854
Cdd:cd04389     32 VLALGGFQTEGIFRVPGDIDEVnELKLRVDQWDYPLSGLEDPHVPASLLKLWLRELEEPLIPDALYQQCISASEDPD--- 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  855 qinAIQRLLQKIPEPNFILLKHLICVL-VIIKDS--STNKLDTNRLSLRLGPHLLwGWTSSDA--FFGkNVSRKLSIIQI 929
Cdd:cd04389    109 ---KAVEIVQKLPIINRLVLCYLINFLqVFAQPEnvAHTKMDVSNLAMVFAPNIL-RCTSDDPrvIFE-NTRKEMSFLRT 183


                   ....
gi 1939401961  930 MIDN 933
Cdd:cd04389    184 LIEH 187
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 254-374 9.39e-04

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 42.07  E-value: 9.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  254 VHVVAWIFKDFLQNIEGSLMTSKLYD---EWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNE 330
Cdd:cd04379     73 INVITGVLKDYLRELPEPLITPQLYEmvlEALAVALPNDVQTNTHLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNK 152

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1939401961  331 MSSYHLSVGLAPCLLFVPSSCNNGM-----------TNDISKKISLVKFMIENSP 374
Cdd:cd04379    153 MTPQNLAVCFGPVLMFCSQEFSRYGisptskmaavsTVDFKQHIEVLHYLLQIWP 207
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 476-657 9.45e-04

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 41.68  E-value: 9.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  476 LFGKSLTSLFE----DKKLPTPILDMLSIIAEKGHESDHIFKIL--PKESHWsLRYRLDSEQHIDWDEEC-VLVIASVLK 548
Cdd:cd04393      2 VFGVPLQELQQagqpENGVPAVVRHIVEYLEQHGLEQEGLFRVNgnAETVEW-LRQRLDSGEEVDLSKEAdVCSAASLLR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  549 DFIINIDGSLLTLEFYENWLSIPDEGTL-AEKINAIQSLLQQIPEPNFILLKHLVYVLVII-KDSSMNNLDSYRLSLRIA 626
Cdd:cd04393     81 LFLQELPEGLIPASLQIRLMQLYQDYNGeDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVaSQHHENRMTAENLAAVFG 160

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1939401961  627 PHVLWGKTSRDSLFGTDVLRKlsIMQIMIDN 657
Cdd:cd04393    161 PDVFHVYTDVEDMKEQEICSR--IMAKLLEN 189
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 543-661 1.23e-03

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 41.69  E-value: 1.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  543 IASVLKDFIINIDGSLLTLEFYENWLSIPDEGTLAEKINAIQSLLQQIPEPNFILLKHLVYVL-VIIKDSSMNNLDSYRL 621
Cdd:cd04394     72 VAGLLKQFFRELPEPLLPYDLHEALLKAQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLyDVAQRCSENKMDSSNL 151

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1939401961  622 SLRIAPHVLW--GKTSRDSLFGTDVLRKL-SIMQIMIDNYHEI 661
Cdd:cd04394    152 AVIFAPNLFQseEGGEKMSSSTEKRLRLQaAVVQTLIDNASNI 194
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 189-372 1.61e-03

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 41.56  E-value: 1.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  189 LFGRELSS-ICQDGDLPSAILDMLYL------LKKEGPTTKGVFIEPPSTTLFQTVKDKLDS---GEEVDIEKQSVHVVA 258
Cdd:cd04391      1 LFGVPLSTlLERDQKKVPGSKVPLIFqklinkLEERGLETEGILRIPGSAQRVKFLCQELEAkfyEGTFLWDQVKQHDAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  259 WIFKDFLQNIEGSLMTSKLYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSV 338
Cdd:cd04391     81 SLLKLFIRELPQPLLTVEYLPAFYSVQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVAM 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1939401961  339 GLAPClLFVPSSCNNGMTNDISKKI-------SLVKFMIEN 372
Cdd:cd04391    161 IMAPN-LFPPRGKHSKDNESLQEEVnmaagcaNIMRLLIRY 200
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 819-906 2.34e-03

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 40.56  E-value: 2.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  819 IASVLKDFITHIDGSLLTCELYESWLSVPDEGTLAEQINAIQRLLQKIPEPNFILLKHLICVLVIIKDSS--TNKLDTNr 896
Cdd:cd04384     75 VSSLCKLYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCsiTNMHAKN- 153

                           90
                   ....*....|
gi 1939401961  897 LSLRLGPHLL 906
Cdd:cd04384    154 LAIVWAPNLL 163
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 1078-1206 2.62e-03

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 40.37  E-value: 2.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1078 IESEELIDWNeegILVIASVLKDFITNIEGSLLTSDLYESWLSVPDEGTLAGKINAIQRLLLKIPQANFILLKHLICVLV 1157
Cdd:cd04406     57 ANSVNLDDYN---IHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLV 133

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1939401961 1158 KIR-DSSMNNLDSNNLSVRIAPYVLWNQTPKDTLFG-SDVSRKMSIIQIMI 1206
Cdd:cd04406    134 RIAlQEETNRMSANALAIVFAPCILRCPDTTDPLQSvQDISKTTTCVELIV 184
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 204-351 2.63e-03

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 40.63  E-value: 2.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  204 PSAILDMLYLLKKEG---PTTKGVFIEPPSTTLFQTVKDKLDSgeeVDIEKQSVHVVAWIFKDFLQNIEGSLMTSKLYDE 280
Cdd:cd04388     16 PPLLIKLVEAIEKKGlesSTLYRTQSSSSLTELRQILDCDAAS---VDLEQFDVAALADALKRYLLDLPNPVIPAPVYSE 92

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1939401961  281 WIAVTEKVNDEEKLVAVQSLLDK---MPPENAALLRQLFRILYEIKNNSAVNEMSSYHLSVGLAPCLLFVPSSC 351
Cdd:cd04388     93 MISRAQEVQSSDEYAQLLRKLIRspnLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALAEIFSPLLFRFQPAS 166
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 543-615 2.84e-03

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 40.57  E-value: 2.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  543 IASVLKDFIINIDGSLLTLEFYENWLSIPDE------------GTLAEKINAIQSLLQQIPEPNFILLKHLVYVLVIIKD 610
Cdd:cd04408     71 ITSVLKHFLKELPEPVLPFQLYDDFIALAKElqrdsekaaespSIVENIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAE 150


                   ....*
gi 1939401961  611 SSMNN 615
Cdd:cd04408    151 RFEDN 155
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 1036-1208 4.78e-03

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 39.68  E-value: 4.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1036 YVDSKLPApILEMLS--IIAEKGKESDQIFAIlPEN--SHWSLRERIESEELIDWNEEGILVIASVLKDFITNIEGSLLT 1111
Cdd:cd04389     16 YPELKLPW-ILTFLSekVLALGGFQTEGIFRV-PGDidEVNELKLRVDQWDYPLSGLEDPHVPASLLKLWLRELEEPLIP 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1112 SDLYESWLSVPDEGTlagKINAIQRLLLKIPQANFILLKHLICVLVKIRDSSMNNLDSNNLSVRIAPYVLWNQ-TPKDTL 1190
Cdd:cd04389     94 DALYQQCISASEDPD---KAVEIVQKLPIINRLVLCYLINFLQVFAQPENVAHTKMDVSNLAMVFAPNILRCTsDDPRVI 170

                          170
                   ....*....|....*...
gi 1939401961 1191 FGsDVSRKMSIIQIMIDN 1208
Cdd:cd04389    171 FE-NTRKEMSFLRTLIEH 187
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 1091-1212 5.10e-03

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 39.58  E-value: 5.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961 1091 ILVIASVLKDFITNIEGSLLTSDLYESWL---SVPDEGTLagkINAIQRLLLKIPQANFILLKHLICVLVKIRDSSMNNL 1167
Cdd:cd04382     69 IHVICGCLKDFLRSLKEPLITFALWKEFMeaaEILDEDNS---RAALYQAISELPQPNRDTLAFLILHLQRVAQSPECKM 145

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1939401961 1168 DSNNLSVRIAPyvlwnqtpkdTLFGsDVSRKMSIIQIMIDNYSQI 1212
Cdd:cd04382    146 DINNLARVFGP----------TIVG-YSVPNPDPMTILQDTVRQP 179
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 543-615 5.33e-03

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 39.71  E-value: 5.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  543 IASVLKDFIINIDGSLLTLEFYENWLSIPDE--------------GTLAEKINAIQSLLQQIPEPNFILLKHLVYVLVII 608
Cdd:cd04378     71 ISSVLKLFLRQLPEPLILFRLYNDFIALAKEiqrdteedkapntpIEVNRIIRKLKDLLRQLPASNYNTLQHLIAHLYRV 150


                   ....*..
gi 1939401961  609 KDSSMNN 615
Cdd:cd04378    151 AEQFEEN 157
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 799-938 6.90e-03

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 39.62  E-value: 6.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939401961  799 LRDKIDTYQYINWNEERV-----LVIASVLKDFITHIDGSLLTCELYE----SWLSVP--DEGTLAEQINAIQRLLQKIP 867
Cdd:cd04399     56 LRNLLNKPKKPDKEVIILkkfepSTVASVLKLYLLELPDSLIPHDIYDlirsLYSAYPpsQEDSDTARIQGLQSTLSQLP 135

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1939401961  868 EPNFILL----KHLICVLVIIKDSSTNKLDTNRLSLRLGPHLLWGWTSSDAFFGKNVSRKlsIIQIMIDNYHQIF 938
Cdd:cd04399    136 KSHIATLdaiiTHFYRLIEITKMGESEEEYADKLATSLSREILRPIIESLLTIGDKHGYK--FFRDLLTHKDQIF 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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