NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|55925323|ref|NP_001007403|]
View 

transducin beta-like protein 3 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 16652346)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
70-599 1.01e-74

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 250.21  E-value: 1.01e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  70 ALSPDDEMLVSASRALLLRQWDWKQQQCRRSWRAVHSVPVASMSFDcTSTLLATGGCDGTIKLWDVIKQYCTHNLKGSSG 149
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 150 VVHLVEFHPDisRLQLFSSSSDCAIRIWDLRSSRCVCVLESHYSPVTALAFSPDGHTLVSSGRDKICSVWDLQEQKVKRT 229
Cdd:COG2319  80 AVLSVAFSPD--GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 230 IPVYE-AVEGVVllsgsadYSemgvkSDALHLVTAGSKGVLRVWDSSSSRCVFTqtlpdasshtededaedeerlgllql 308
Cdd:COG2319 158 LTGHSgAVTSVA-------FS-----PDGKLLASGSDDGTVRLWDLATGKLLRT-------------------------- 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 309 lllprtgrlitvtaehnillyqtptlavqqqfvgynddvldvkfvgkddthiavatnssqlkvfelstnscqiLHGHTDT 388
Cdd:COG2319 200 -------------------------------------------------------------------------LTGHTGA 206

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 389 ILSIDVFRKGSMFATCAKDKSVRVWrmDVSSGRvhCVAQGTGHSNAVGSIACSRmKQQFVVSGSQDCTVKVWDLpeTTGa 468
Cdd:COG2319 207 VRSVAFSPDGKLLASGSADGTVRLW--DLATGK--LLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDL--ATG- 278

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 469 egvmmmKARSTERAHEKDVNSVCVSPNDKLLASGSQDRTAKLWALSDLRLLGVCRGHRRGVWSVQFSPVDQILGSASADG 548
Cdd:COG2319 279 ------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDG 352

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|.
gi 55925323 549 SVRIWSIQDFSCLKTFEGHDASVLKIIFVSRGTQLVSSGSDGLVKLWTIKT 599
Cdd:COG2319 353 TVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
Utp13 pfam08625
Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex ...
 659-791 4.18e-50

Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end.


:

Pssm-ID: 462540  Cd Length: 139  Bit Score: 172.69  E-value: 4.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323   659 QQELQNLLHEHQYVKALGVAISLDQPHTAPRVIREI------RQREDGVQELEKTLLKLRKDQKESVLRYCTVWNTNSRS 732
Cdd:pfam08625   1 EQELQNLLRNKDYREAILLALTLNHPHRLLKLFKALltsaddEGSITGLKELDEVIKTLSDEQLEKLLKYIRDWNTNAKT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 55925323   733 CLDAQAVLKVLLTHLSPEEMLQFQSAHTHLQALVPYTERHMQRINRLLQASMFLDYMWQ 791
Cdd:pfam08625  81 SHVAQRVLNALLKSYPPEELLELPGLKEILEALIPYTERHFSRLDRLVQESYLLDYTLQ 139
PLN00181 super family cl31831
protein SPA1-RELATED; Provisional
 581-651 9.20e-05

protein SPA1-RELATED; Provisional


The actual alignment was detected with superfamily member PLN00181:

Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.23  E-value: 9.20e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55925323  581 TQLVSSGSDGLVKLWTIKTNECVRTLDAHQDKVWALHGGCRD-ELMVTGSADSTITVWKDVTEVELAEEQAK 651
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTK 617
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
70-599 1.01e-74

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 250.21  E-value: 1.01e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  70 ALSPDDEMLVSASRALLLRQWDWKQQQCRRSWRAVHSVPVASMSFDcTSTLLATGGCDGTIKLWDVIKQYCTHNLKGSSG 149
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 150 VVHLVEFHPDisRLQLFSSSSDCAIRIWDLRSSRCVCVLESHYSPVTALAFSPDGHTLVSSGRDKICSVWDLQEQKVKRT 229
Cdd:COG2319  80 AVLSVAFSPD--GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 230 IPVYE-AVEGVVllsgsadYSemgvkSDALHLVTAGSKGVLRVWDSSSSRCVFTqtlpdasshtededaedeerlgllql 308
Cdd:COG2319 158 LTGHSgAVTSVA-------FS-----PDGKLLASGSDDGTVRLWDLATGKLLRT-------------------------- 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 309 lllprtgrlitvtaehnillyqtptlavqqqfvgynddvldvkfvgkddthiavatnssqlkvfelstnscqiLHGHTDT 388
Cdd:COG2319 200 -------------------------------------------------------------------------LTGHTGA 206

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 389 ILSIDVFRKGSMFATCAKDKSVRVWrmDVSSGRvhCVAQGTGHSNAVGSIACSRmKQQFVVSGSQDCTVKVWDLpeTTGa 468
Cdd:COG2319 207 VRSVAFSPDGKLLASGSADGTVRLW--DLATGK--LLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDL--ATG- 278

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 469 egvmmmKARSTERAHEKDVNSVCVSPNDKLLASGSQDRTAKLWALSDLRLLGVCRGHRRGVWSVQFSPVDQILGSASADG 548
Cdd:COG2319 279 ------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDG 352

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|.
gi 55925323 549 SVRIWSIQDFSCLKTFEGHDASVLKIIFVSRGTQLVSSGSDGLVKLWTIKT 599
Cdd:COG2319 353 TVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 338-638 1.94e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 207.19  E-value: 1.94e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 338 QQFVGYNDDVLDVKFVgKDDTHIAVATNSSQLKVFELSTNSCQI-LHGHTDTILSIDVFRKGSMFATCAKDKSVRVWrmD 416
Cdd:cd00200   3 RTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVAASADGTYLASGSSDKTIRLW--D 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 417 VSSGRvhCVAQGTGHSNAVGSIACSRmKQQFVVSGSQDCTVKVWDLPETtgaegvmmmKARSTERAHEKDVNSVCVSPND 496
Cdd:cd00200  80 LETGE--CVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETG---------KCLTTLRGHTDWVNSVAFSPDG 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 497 KLLASGSQDRTAKLWALSDLRLLGVCRGHRRGVWSVQFSPVDQILGSASADGSVRIWSIQDFSCLKTFEGHDASVLKIIF 576
Cdd:cd00200 148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55925323 577 VSRGTQLVSSGSDGLVKLWTIKTNECVRTLDAHQDKVWALH---GGCRdelMVTGSADSTITVWK 638
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAwspDGKR---LASGSADGTIRIWD 289
Utp13 pfam08625
Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex ...
 659-791 4.18e-50

Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end.


Pssm-ID: 462540  Cd Length: 139  Bit Score: 172.69  E-value: 4.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323   659 QQELQNLLHEHQYVKALGVAISLDQPHTAPRVIREI------RQREDGVQELEKTLLKLRKDQKESVLRYCTVWNTNSRS 732
Cdd:pfam08625   1 EQELQNLLRNKDYREAILLALTLNHPHRLLKLFKALltsaddEGSITGLKELDEVIKTLSDEQLEKLLKYIRDWNTNAKT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 55925323   733 CLDAQAVLKVLLTHLSPEEMLQFQSAHTHLQALVPYTERHMQRINRLLQASMFLDYMWQ 791
Cdd:pfam08625  81 SHVAQRVLNALLKSYPPEELLELPGLKEILEALIPYTERHFSRLDRLVQESYLLDYTLQ 139
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 386-597 4.04e-13

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 73.58  E-value: 4.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  386 TDTILSIDVFRKGSMFATCAKDKSVRVWRMD--VSSGR-VHC-VAQGTGHSNAVGSIACSRMKQQfVVSGSQDCTVKVWD 461
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECEsiIKDGRdIHYpVVELASRSKLSGICWNSYIKSQ-VASSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  462 LPETtgaEGVMMMKArsteraHEKDVNSVCVSPND-KLLASGSQDRTAKLWALSDLRLLGVCRGhRRGVWSVQF-SPVDQ 539
Cdd:PLN00181 562 VARS---QLVTEMKE------HEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGR 631

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 55925323  540 ILGSASADGSVRIWSIQDFSC-LKTFEGHDASVLKIIFVSRGTqLVSSGSDGLVKLWTI 597
Cdd:PLN00181 632 SLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 181-220 3.38e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 3.38e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 55925323    181 SSRCVCVLESHYSPVTALAFSPDGHTLVSSGRDKICSVWD 220
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
182-220 2.34e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 2.34e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 55925323   182 SRCVCVLESHYSPVTALAFSPDGHTLVSSGRDKICSVWD 220
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 581-651 9.20e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.23  E-value: 9.20e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55925323  581 TQLVSSGSDGLVKLWTIKTNECVRTLDAHQDKVWALHGGCRD-ELMVTGSADSTITVWKDVTEVELAEEQAK 651
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTK 617
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 599-638 5.44e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 5.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 55925323    599 TNECVRTLDAHQDKVWALHGGCRDELMVTGSADSTITVWK 638
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
600-637 5.97e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.97e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 55925323   600 NECVRTLDAHQDKVWALHGGCRDELMVTGSADSTITVW 637
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
70-599 1.01e-74

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 250.21  E-value: 1.01e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  70 ALSPDDEMLVSASRALLLRQWDWKQQQCRRSWRAVHSVPVASMSFDcTSTLLATGGCDGTIKLWDVIKQYCTHNLKGSSG 149
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 150 VVHLVEFHPDisRLQLFSSSSDCAIRIWDLRSSRCVCVLESHYSPVTALAFSPDGHTLVSSGRDKICSVWDLQEQKVKRT 229
Cdd:COG2319  80 AVLSVAFSPD--GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 230 IPVYE-AVEGVVllsgsadYSemgvkSDALHLVTAGSKGVLRVWDSSSSRCVFTqtlpdasshtededaedeerlgllql 308
Cdd:COG2319 158 LTGHSgAVTSVA-------FS-----PDGKLLASGSDDGTVRLWDLATGKLLRT-------------------------- 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 309 lllprtgrlitvtaehnillyqtptlavqqqfvgynddvldvkfvgkddthiavatnssqlkvfelstnscqiLHGHTDT 388
Cdd:COG2319 200 -------------------------------------------------------------------------LTGHTGA 206

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 389 ILSIDVFRKGSMFATCAKDKSVRVWrmDVSSGRvhCVAQGTGHSNAVGSIACSRmKQQFVVSGSQDCTVKVWDLpeTTGa 468
Cdd:COG2319 207 VRSVAFSPDGKLLASGSADGTVRLW--DLATGK--LLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDL--ATG- 278

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 469 egvmmmKARSTERAHEKDVNSVCVSPNDKLLASGSQDRTAKLWALSDLRLLGVCRGHRRGVWSVQFSPVDQILGSASADG 548
Cdd:COG2319 279 ------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDG 352

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|.
gi 55925323 549 SVRIWSIQDFSCLKTFEGHDASVLKIIFVSRGTQLVSSGSDGLVKLWTIKT 599
Cdd:COG2319 353 TVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 338-638 1.94e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 207.19  E-value: 1.94e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 338 QQFVGYNDDVLDVKFVgKDDTHIAVATNSSQLKVFELSTNSCQI-LHGHTDTILSIDVFRKGSMFATCAKDKSVRVWrmD 416
Cdd:cd00200   3 RTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVAASADGTYLASGSSDKTIRLW--D 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 417 VSSGRvhCVAQGTGHSNAVGSIACSRmKQQFVVSGSQDCTVKVWDLPETtgaegvmmmKARSTERAHEKDVNSVCVSPND 496
Cdd:cd00200  80 LETGE--CVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETG---------KCLTTLRGHTDWVNSVAFSPDG 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 497 KLLASGSQDRTAKLWALSDLRLLGVCRGHRRGVWSVQFSPVDQILGSASADGSVRIWSIQDFSCLKTFEGHDASVLKIIF 576
Cdd:cd00200 148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55925323 577 VSRGTQLVSSGSDGLVKLWTIKTNECVRTLDAHQDKVWALH---GGCRdelMVTGSADSTITVWK 638
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAwspDGKR---LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 378-647 3.81e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 201.02  E-value: 3.81e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 378 SCQILHGHTDTILSIDVFRKGSMFATCAKDKSVRVWrmDVSSGRvhCVAQGTGHSNAVGSIACSRmKQQFVVSGSQDCTV 457
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW--DLETGE--LLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 458 KVWDLpeTTGAEgvmmmkaRSTERAHEKDVNSVCVSPNDKLLASGSQDRTAKLWALSDLRLLGVCRGHRRGVWSVQFSPV 537
Cdd:cd00200  76 RLWDL--ETGEC-------VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 538 DQILGSASADGSVRIWSIQDFSCLKTFEGHDASVLKIIFVSRGTQLVSSGSDGLVKLWTIKTNECVRTLDAHQDKVWALH 617
Cdd:cd00200 147 GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA 226

                       250       260       270
                ....*....|....*....|....*....|
gi 55925323 618 GGCRDELMVTGSADSTITVWKDVTEVELAE 647
Cdd:cd00200 227 FSPDGYLLASGSEDGTIRVWDLRTGECVQT 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 184-595 9.93e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 194.09  E-value: 9.93e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 184 CVCVLESHYSPVTALAFSPDGHTLVSSGRDKICSVWDLQEQKVKRTIPVYEAVEGVVLLSGSADYsemgvksdalhLVTA 263
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-----------LASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 264 GSKGVLRVWDSSSSRCVFTqtlpdasshtededaedeerlgllqllllprtgrlitvtaehnillyqtptlavqqqfvgy 343
Cdd:cd00200  70 SSDKTIRLWDLETGECVRT------------------------------------------------------------- 88

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 344 nddvldvkfvgkddthiavatnssqlkvfelstnscqiLHGHTDTILSIDVFRKGSMFATCAKDKSVRVWrmDVSSGRvh 423
Cdd:cd00200  89 --------------------------------------LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW--DVETGK-- 126

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 424 CVAQGTGHSNAVGSIACSRmKQQFVVSGSQDCTVKVWDLPEttgaegvmmMKARSTERAHEKDVNSVCVSPNDKLLASGS 503
Cdd:cd00200 127 CLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRT---------GKCVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 504 QDRTAKLWALSDLRLLGVCRGHRRGVWSVQFSPVDQILGSASADGSVRIWSIQDFSCLKTFEGHDASVLKIIFVSRGTQL 583
Cdd:cd00200 197 SDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL 276

                       410
                ....*....|..
gi 55925323 584 VSSGSDGLVKLW 595
Cdd:cd00200 277 ASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
26-515 2.79e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 2.79e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  26 RVQVSADEQHI-FCTYGPKINILQISTGKIIHSIeQEDQEDITAFALSPDDEMLVSASRALLLRQWDWKQQQCRRSWRAv 104
Cdd:COG2319  83 SVAFSPDGRLLaSASADGTVRLWDLATGLLLRTL-TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG- 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 105 HSVPVASMSFDCTSTLLATGGCDGTIKLWDVIKQYCTHNLKGSSGVVHLVEFHPDiSRLqLFSSSSDCAIRIWDLRSSRC 184
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKL-LASGSADGTVRLWDLATGKL 238

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 185 VCVLESHYSPVTALAFSPDGHTLVSSGRDkicsvwdlqeqkvkrtipvyeavegvvllsgsadysemgvksdalhlvtag 264
Cdd:COG2319 239 LRTLTGHSGSVRSVAFSPDGRLLASGSAD--------------------------------------------------- 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 265 skGVLRVWDSSSSRCVFTqtlpdasshtededaedeerlgllqllllprtgrlitvtaehnillyqtptlavqqqfvgyn 344
Cdd:COG2319 268 --GTVRLWDLATGELLRT-------------------------------------------------------------- 283

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 345 ddvldvkfvgkddthiavatnssqlkvfelstnscqiLHGHTDTILSIDVFRKGSMFATCAKDKSVRVWrmDVSSGRvhC 424
Cdd:COG2319 284 -------------------------------------LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW--DLATGK--L 322

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 425 VAQGTGHSNAVGSIACSRmKQQFVVSGSQDCTVKVWDLpeTTGAEgvmmmkaRSTERAHEKDVNSVCVSPNDKLLASGSQ 504
Cdd:COG2319 323 LRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDL--ATGEL-------LRTLTGHTGAVTSVAFSPDGRTLASGSA 392

                       490
                ....*....|.
gi 55925323 505 DRTAKLWALSD 515
Cdd:COG2319 393 DGTVRLWDLAT 403
Utp13 pfam08625
Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex ...
 659-791 4.18e-50

Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end.


Pssm-ID: 462540  Cd Length: 139  Bit Score: 172.69  E-value: 4.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323   659 QQELQNLLHEHQYVKALGVAISLDQPHTAPRVIREI------RQREDGVQELEKTLLKLRKDQKESVLRYCTVWNTNSRS 732
Cdd:pfam08625   1 EQELQNLLRNKDYREAILLALTLNHPHRLLKLFKALltsaddEGSITGLKELDEVIKTLSDEQLEKLLKYIRDWNTNAKT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 55925323   733 CLDAQAVLKVLLTHLSPEEMLQFQSAHTHLQALVPYTERHMQRINRLLQASMFLDYMWQ 791
Cdd:pfam08625  81 SHVAQRVLNALLKSYPPEELLELPGLKEILEALIPYTERHFSRLDRLVQESYLLDYTLQ 139
WD40 COG2319
WD40 repeat [General function prediction only];
382-637 7.12e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 181.65  E-value: 7.12e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 382 LHGHTDTILSIDVFRKGSMFATCAKDKSVRVWRmdvsSGRVHCVAQGTGHSNAVGSIACSRMKQQfVVSGSQDCTVKVWD 461
Cdd:COG2319  32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLD----AAAGALLATLLGHTAAVLSVAFSPDGRL-LASASADGTVRLWD 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 462 LpeTTGAEgvmmmkaRSTERAHEKDVNSVCVSPNDKLLASGSQDRTAKLWALSDLRLLGVCRGHRRGVWSVQFSPVDQIL 541
Cdd:COG2319 107 L--ATGLL-------LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLL 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 542 GSASADGSVRIWSIQDFSCLKTFEGHDASVLKIIFVSRGTQLVSSGSDGLVKLWTIKTNECVRTLDAHQDKVWAL---HG 618
Cdd:COG2319 178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVafsPD 257

                       250
                ....*....|....*....
gi 55925323 619 GcrdELMVTGSADSTITVW 637
Cdd:COG2319 258 G---RLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 105-461 9.89e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 174.45  E-value: 9.89e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 105 HSVPVASMSFDCTSTLLATGGCDGTIKLWDVIKQYCTHNLKGSSGVVHLVEFHPDisRLQLFSSSSDCAIRIWDLRSSRC 184
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAD--GTYLASGSSDKTIRLWDLETGEC 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 185 VCVLESHYSPVTALAFSPDGHTLVSSGRDKICSVWDLQEQKVKRTIPVYEAVEGVVLLSGSADYsemgvksdalhLVTAG 264
Cdd:cd00200  86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF-----------VASSS 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 265 SKGVLRVWDSSSSRCVftqtlpdasshtededaedeerlgllqllllprtgrlitvtaehnillyqtptlavqQQFVGYN 344
Cdd:cd00200 155 QDGTIKLWDLRTGKCV---------------------------------------------------------ATLTGHT 177

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 345 DDVLDVKFVGkDDTHIAVATNSSQLKVFELSTNSC-QILHGHTDTILSIDVFRKGSMFATCAKDKSVRVWrmDVSSGRvh 423
Cdd:cd00200 178 GEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKClGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW--DLRTGE-- 252

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 55925323 424 CVAQGTGHSNAVGSIACSRmKQQFVVSGSQDCTVKVWD 461
Cdd:cd00200 253 CVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 66-282 5.55e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 146.71  E-value: 5.55e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  66 ITAFALSPDDEMLVSASRALLLRQWDWKQQQCRRSWRAvHSVPVASMSFDCTSTLLATGGCDGTIKLWDVIKQYCTHNLK 145
Cdd:cd00200  54 VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 146 GSSGVVHLVEFHPDisRLQLFSSSSDCAIRIWDLRSSRCVCVLESHYSPVTALAFSPDGHTLVSSGRDKICSVWDLQEQK 225
Cdd:cd00200 133 GHTDWVNSVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 55925323 226 VKRTIPVYE-AVEGVVLLSGSadysemgvksdalHLVTAGSK-GVLRVWDSSSSRCVFT 282
Cdd:cd00200 211 CLGTLRGHEnGVNSVAFSPDG-------------YLLASGSEdGTIRVWDLRTGECVQT 256
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 386-597 4.04e-13

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 73.58  E-value: 4.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  386 TDTILSIDVFRKGSMFATCAKDKSVRVWRMD--VSSGR-VHC-VAQGTGHSNAVGSIACSRMKQQfVVSGSQDCTVKVWD 461
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECEsiIKDGRdIHYpVVELASRSKLSGICWNSYIKSQ-VASSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  462 LPETtgaEGVMMMKArsteraHEKDVNSVCVSPND-KLLASGSQDRTAKLWALSDLRLLGVCRGhRRGVWSVQF-SPVDQ 539
Cdd:PLN00181 562 VARS---QLVTEMKE------HEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGR 631

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 55925323  540 ILGSASADGSVRIWSIQDFSC-LKTFEGHDASVLKIIFVSRGTqLVSSGSDGLVKLWTI 597
Cdd:PLN00181 632 SLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDL 689
PTZ00421 PTZ00421
coronin; Provisional
 108-226 2.06e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 57.60  E-value: 2.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  108 PVASMSFD-CTSTLLATGGCDGTIKLWDV----IKQYCTHN---LKGSSGVVHLVEFHPDISRLqLFSSSSDCAIRIWDL 179
Cdd:PTZ00421  77 PIIDVAFNpFDPQKLFTASEDGTIMGWGIpeegLTQNISDPivhLQGHTKKVGIVSFHPSAMNV-LASAGADMVVNVWDV 155

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 55925323  180 RSSRCVCVLESHYSPVTALAFSPDGHTLVSSGRDKICSVWDLQEQKV 226
Cdd:PTZ00421 156 ERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTI 202
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 181-220 3.38e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 3.38e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 55925323    181 SSRCVCVLESHYSPVTALAFSPDGHTLVSSGRDKICSVWD 220
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 113-221 6.96e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 6.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  113 SFDCTS---TLLATGGCDGTIKLWDVIKQYCTHNLKGSSGVVhLVEFHPDISRLQLFsSSSDCAIRIWDLRSSRC-VCVL 188
Cdd:PLN00181 580 SIDYSSadpTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC-CVQFPSESGRSLAF-GSADHKVYYYDLRNPKLpLCTM 657

                         90       100       110
                 ....*....|....*....|....*....|...
gi 55925323  189 ESHYSPVTALAFSpDGHTLVSSGRDKICSVWDL 221
Cdd:PLN00181 658 IGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
182-220 2.34e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 2.34e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 55925323   182 SRCVCVLESHYSPVTALAFSPDGHTLVSSGRDKICSVWD 220
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 515-554 9.00e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 9.00e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 55925323    515 DLRLLGVCRGHRRGVWSVQFSPVDQILGSASADGSVRIWS 554
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 481-511 2.95e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 2.95e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55925323    481 RAHEKDVNSVCVSPNDKLLASGSQDRTAKLW 511
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
517-554 3.30e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 3.30e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 55925323   517 RLLGVCRGHRRGVWSVQFSPVDQILGSASADGSVRIWS 554
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 102-225 4.24e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 50.33  E-value: 4.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  102 RAVHSVPVAsmsfdCTSTLLAT------GGCDGTIKLWDVIKQYCTHNLKGSSGVVHLVEFHPDISRLqLFSSSSDCAIR 175
Cdd:PTZ00420  27 RVIDSCGIA-----CSSGFVAVpwevegGGLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEI-LASGSEDLTIR 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 55925323  176 IWDLRSSR--------CVCVLESHYSPVTALAFSP-DGHTLVSSGRDKICSVWDLQEQK 225
Cdd:PTZ00420 101 VWEIPHNDesvkeikdPQCILKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
481-511 5.18e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 5.18e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 55925323   481 RAHEKDVNSVCVSPNDKLLASGSQDRTAKLW 511
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 399-589 5.39e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 5.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  399 SMFATCAKDKSVRVWrmDVSsgRVHCVAQGTGHSNAVGSIACSRMKQQFVVSGSQDCTVKVWDLPETTGAeGVMMMKArs 478
Cdd:PLN00181 546 SQVASSNFEGVVQVW--DVA--RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSI-GTIKTKA-- 618

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  479 terahekdvNSVCVS-PND--KLLASGSQDRTAKLWALSDLRL-LGVCRGHRRGVWSVQFspVD-QILGSASADGSVRIW 553
Cdd:PLN00181 619 ---------NICCVQfPSEsgRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRF--VDsSTLVSSSTDNTLKLW 687

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 55925323  554 SIQ------DFSCLKTFEGHdASVLKIIFVSRGTQLVSSGSD 589
Cdd:PLN00181 688 DLSmsisgiNETPLHSFMGH-TNVKNFVGLSVSDGYIATGSE 728
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 557-595 5.58e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 5.58e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 55925323    557 DFSCLKTFEGHDASVLKIIFVSRGTQLVSSGSDGLVKLW 595
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 375-413 2.34e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 2.34e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 55925323    375 STNSCQILHGHTDTILSIDVFRKGSMFATCAKDKSVRVW 413
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 94-134 3.64e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 3.64e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 55925323     94 QQQCRRSWRAvHSVPVASMSFDCTSTLLATGGCDGTIKLWD 134
Cdd:smart00320   1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
558-595 4.36e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 4.36e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 55925323   558 FSCLKTFEGHDASVLKIIFVSRGTQLVSSGSDGLVKLW 595
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
96-134 6.09e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 6.09e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 55925323    96 QCRRSWRAvHSVPVASMSFDCTSTLLATGGCDGTIKLWD 134
Cdd:pfam00400   2 KLLKTLEG-HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 581-651 9.20e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.23  E-value: 9.20e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55925323  581 TQLVSSGSDGLVKLWTIKTNECVRTLDAHQDKVWALHGGCRD-ELMVTGSADSTITVWKDVTEVELAEEQAK 651
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTK 617
WD40 pfam00400
WD domain, G-beta repeat;
424-461 1.48e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 55925323   424 CVAQGTGHSNAVGSIACSRmKQQFVVSGSQDCTVKVWD 461
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 524-636 1.58e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 1.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  524 GHRRGVWSVQFSPVD-QILGSASADGSVRIWSIQD-------FSCLKTFEGHDASVLKIIF-VSRGTQLVSSGSDGLVKL 594
Cdd:PTZ00421  73 GQEGPIIDVAFNPFDpQKLFTASEDGTIMGWGIPEegltqniSDPIVHLQGHTKKVGIVSFhPSAMNVLASAGADMVVNV 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 55925323  595 WTIKTNECVRTLDAHQDKVWALHGGCRDELMVTGSADSTITV 636
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
380-413 2.88e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 2.88e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 55925323   380 QILHGHTDTILSIDVFRKGSMFATCAKDKSVRVW 413
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 423-461 4.65e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 4.65e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 55925323    423 HCVAQGTGHSNAVGSIACSRmKQQFVVSGSQDCTVKVWD 461
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 599-638 5.44e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 5.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 55925323    599 TNECVRTLDAHQDKVWALHGGCRDELMVTGSADSTITVWK 638
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
600-637 5.97e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.97e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 55925323   600 NECVRTLDAHQDKVWALHGGCRDELMVTGSADSTITVW 637
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
118-241 3.26e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 3.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323 118 STLLATGGCDGTIKLWDVIKQYCTHNLKGSSGVVHLVeFHPDISRLqLFSSSSDCAIRIWDLRSSRCVCVLESHYSPvTA 197
Cdd:COG3391  80 RRLYVANSGSGRVSVIDLATGKVVATIPVGGGPRGLA-VDPDGGRL-YVADSGNGRVSVIDTATGKVVATIPVGAGP-HG 156

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 55925323 198 LAFSPDGHTL-VSSGRD----KICSVWDLQEQKVKRTIPVYEAVEGVVL 241
Cdd:COG3391 157 IAVDPDGKRLyVANSGSntvsVIVSVIDTATGKVVATIPVGGGPVGVAV 205
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 140-178 7.33e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 7.33e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 55925323    140 CTHNLKGSSGVVHLVEFHPDISRLqlFSSSSDCAIRIWD 178
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYL--ASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 105-193 8.15e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.88  E-value: 8.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925323  105 HSVPVASMSFDCTST-LLATGGCDGTIKLWDVIKQYCTHNLKGSSGVVHLVEFHPDISrlQLFSSSSDCAIRIWDLRSSR 183
Cdd:PTZ00421 124 HTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGS--LLCTTSKDKKLNIIDPRDGT 201

                         90
                 ....*....|
gi 55925323  184 CVCVLESHYS 193
Cdd:PTZ00421 202 IVSSVEAHAS 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH