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Conserved domains on  [gi|55925514|ref|NP_001007296|]
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uncharacterized protein LOC492329 [Danio rerio]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 11108663)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 872-1057 2.11e-115

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239854  Cd Length: 187  Bit Score: 353.62  E-value: 2.11e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  872 FGSSLEEVMERQSELFPDRKLPWVQVQLSQYVLALGGAQTEGIFRVPGDIDEVNALKLQVDQWRIP-ENLSDPNVPASLM 950
Cdd:cd04389    1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPlSGLEDPHVPASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  951 KLWYRELEEPLIPMTFYKHCVSNYDDPAAAISVVQSLPELNRLVLSYFIHFLQVFAQPSNVSVTKMDVNNLAMVMAPNCL 1030
Cdd:cd04389   81 KLWLRELEEPLIPDALYQQCISASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENVAHTKMDVSNLAMVFAPNIL 160

                        170       180
                 ....*....|....*....|....*..
gi 55925514 1031 RCQSDDPRVIFENTRKEMSFLRMLIVH 1057
Cdd:cd04389  161 RCTSDDPRVIFENTRKEMSFLRTLIEH 187
MyTH4 pfam00784
MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also ...
 723-861 7.22e-31

MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.


:

Pssm-ID: 459939  Cd Length: 105  Bit Score: 116.91  E-value: 7.22e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514    723 IVTKCWGMQGLRDELYVQLVRQTTGNTSPRSLAAGWELMAVCLAFFAPSPKFCCYLEGYIQRHIEPTNDkkitqfildqq 802
Cdd:pfam00784    4 ILQKGLKRPELRDEIYCQLIKQTTNNPKPESLLRGWQLLALCLGTFPPSKKLLKYLLKFLKRHADDPSR----------- 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 55925514    803 dskkknsksrkkrkqnsdeeaealPISTYAKYCYRKLQKVAITGGKKglRKPSLEEVDH 861
Cdd:pfam00784   73 ------------------------EVGKYAQFCLKRLKRTLKNGGRK--YPPSREEIEA 105
 
Name Accession Description Interval E-value
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 872-1057 2.11e-115

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 353.62  E-value: 2.11e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  872 FGSSLEEVMERQSELFPDRKLPWVQVQLSQYVLALGGAQTEGIFRVPGDIDEVNALKLQVDQWRIP-ENLSDPNVPASLM 950
Cdd:cd04389    1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPlSGLEDPHVPASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  951 KLWYRELEEPLIPMTFYKHCVSNYDDPAAAISVVQSLPELNRLVLSYFIHFLQVFAQPSNVSVTKMDVNNLAMVMAPNCL 1030
Cdd:cd04389   81 KLWLRELEEPLIPDALYQQCISASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENVAHTKMDVSNLAMVFAPNIL 160

                        170       180
                 ....*....|....*....|....*..
gi 55925514 1031 RCQSDDPRVIFENTRKEMSFLRMLIVH 1057
Cdd:cd04389  161 RCTSDDPRVIFENTRKEMSFLRTLIEH 187
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 893-1034 1.05e-36

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 135.37  E-value: 1.05e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514    893 PWVQVQLSQYVLALGgAQTEGIFRVPGDIDEVNALKLQVDQWRIPENL---SDPNVPASLMKLWYRELEEPLIPMTFYKH 969
Cdd:pfam00620    1 PLIVRKCVEYLEKRG-LDTEGIFRVSGSASRIKELREAFDRGPDVDLDleeEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 55925514    970 CVS--NYDDPAAAIS----VVQSLPELNRLVLSYFIHFLQVFAQPSnvSVTKMDVNNLAMVMAPNCLRCQS 1034
Cdd:pfam00620   80 FIEaaKLPDEEERLEalreLLRKLPPANRDTLRYLLAHLNRVAQNS--DVNKMNAHNLAIVFGPTLLRPPD 148
MyTH4 pfam00784
MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also ...
 723-861 7.22e-31

MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 459939  Cd Length: 105  Bit Score: 116.91  E-value: 7.22e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514    723 IVTKCWGMQGLRDELYVQLVRQTTGNTSPRSLAAGWELMAVCLAFFAPSPKFCCYLEGYIQRHIEPTNDkkitqfildqq 802
Cdd:pfam00784    4 ILQKGLKRPELRDEIYCQLIKQTTNNPKPESLLRGWQLLALCLGTFPPSKKLLKYLLKFLKRHADDPSR----------- 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 55925514    803 dskkknsksrkkrkqnsdeeaealPISTYAKYCYRKLQKVAITGGKKglRKPSLEEVDH 861
Cdd:pfam00784   73 ------------------------EVGKYAQFCLKRLKRTLKNGGRK--YPPSREEIEA 105
MyTH4 smart00139
Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 ...
 675-859 2.65e-30

Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 214535  Cd Length: 152  Bit Score: 117.08  E-value: 2.65e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514     675 WNRGSIKKPMLMTNDRTVRKEACEMFKLVQAYMGDRPSRLDRRHAALL--IVTKCWGMQGLRDELYVQLVRQTTGNTSPR 752
Cdd:smart00139    1 YTKDPIKTSLLKLESDELQKEAVKIFKAILKFMGDIPLPRPDSHLDLVqfILQKGLDHPELRDEIYCQLIKQLTDNPSRQ 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514     753 SLAAGWELMAVCLAFFAPSPKFCCYLEGYIQRHIEPtndkkitqfildqqdskkknsksrkkrkqnsdeeaeaLPISTYA 832
Cdd:smart00139   81 SEERGWQLLYLCTSLFPPSERLLPYLLQFLSRRADP-------------------------------------GSEQGLA 123

                           170       180
                    ....*....|....*....|....*..
gi 55925514     833 KYCYRKLQKVAITGGKKglRKPSLEEV 859
Cdd:smart00139  124 KYCLYRLERTLKNGARK--QPPSRLEL 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 908-1057 1.68e-28

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 112.74  E-value: 1.68e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514     908 GAQTEGIFRVPGDIDEVNALKLQVDQWRIP---ENLSDPNVPASLMKLWYRELEEPLIPMTFYKHC--VSNYDDPAAAIS 982
Cdd:smart00324   18 GLDTEGIYRVSGSKSRVKELRDAFDSGPDPdldLSEYDVHDVAGLLKLFLRELPEPLITYELYEEFieAAKLEDETERLR 97

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55925514     983 ----VVQSLPELNRLVLSYFIHFLQVFAQpsNVSVTKMDVNNLAMVMAPNCLRCQSDDPRVIFENTRKeMSFLRMLIVH 1057
Cdd:smart00324   98 alreLLSLLPPANRATLRYLLAHLNRVAE--HSEENKMTARNLAIVFGPTLLRPPDGEVASLKDIRHQ-NTVIEFLIEN 173
 
Name Accession Description Interval E-value
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 872-1057 2.11e-115

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 353.62  E-value: 2.11e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  872 FGSSLEEVMERQSELFPDRKLPWVQVQLSQYVLALGGAQTEGIFRVPGDIDEVNALKLQVDQWRIP-ENLSDPNVPASLM 950
Cdd:cd04389    1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPlSGLEDPHVPASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  951 KLWYRELEEPLIPMTFYKHCVSNYDDPAAAISVVQSLPELNRLVLSYFIHFLQVFAQPSNVSVTKMDVNNLAMVMAPNCL 1030
Cdd:cd04389   81 KLWLRELEEPLIPDALYQQCISASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENVAHTKMDVSNLAMVFAPNIL 160

                        170       180
                 ....*....|....*....|....*..
gi 55925514 1031 RCQSDDPRVIFENTRKEMSFLRMLIVH 1057
Cdd:cd04389  161 RCTSDDPRVIFENTRKEMSFLRTLIEH 187
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 893-1057 3.59e-37

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 137.43  E-value: 3.59e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  893 PWVQVQLSQYVLAlGGAQTEGIFRVPGDIDEVNALKLQVDQWRIPENLS--DPNVPASLMKLWYRELEEPLIPMTFYKHC 970
Cdd:cd00159    1 PLIIEKCIEYLEK-NGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEdyDVHDVASLLKLYLRELPEPLIPFELYDEF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  971 VSNYDDP------AAAISVVQSLPELNRLVLSYFIHFLQVFAQpsNVSVTKMDVNNLAMVMAPNCLRCQSDDpRVIFENT 1044
Cdd:cd00159   80 IELAKIEdeeeriEALKELLKSLPPENRDLLKYLLKLLHKISQ--NSEVNKMTASNLAIVFAPTLLRPPDSD-DELLEDI 156

                        170
                 ....*....|...
gi 55925514 1045 RKEMSFLRMLIVH 1057
Cdd:cd00159  157 KKLNEIVEFLIEN 169
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 893-1034 1.05e-36

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 135.37  E-value: 1.05e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514    893 PWVQVQLSQYVLALGgAQTEGIFRVPGDIDEVNALKLQVDQWRIPENL---SDPNVPASLMKLWYRELEEPLIPMTFYKH 969
Cdd:pfam00620    1 PLIVRKCVEYLEKRG-LDTEGIFRVSGSASRIKELREAFDRGPDVDLDleeEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 55925514    970 CVS--NYDDPAAAIS----VVQSLPELNRLVLSYFIHFLQVFAQPSnvSVTKMDVNNLAMVMAPNCLRCQS 1034
Cdd:pfam00620   80 FIEaaKLPDEEERLEalreLLRKLPPANRDTLRYLLAHLNRVAQNS--DVNKMNAHNLAIVFGPTLLRPPD 148
MyTH4 pfam00784
MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also ...
 723-861 7.22e-31

MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 459939  Cd Length: 105  Bit Score: 116.91  E-value: 7.22e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514    723 IVTKCWGMQGLRDELYVQLVRQTTGNTSPRSLAAGWELMAVCLAFFAPSPKFCCYLEGYIQRHIEPTNDkkitqfildqq 802
Cdd:pfam00784    4 ILQKGLKRPELRDEIYCQLIKQTTNNPKPESLLRGWQLLALCLGTFPPSKKLLKYLLKFLKRHADDPSR----------- 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 55925514    803 dskkknsksrkkrkqnsdeeaealPISTYAKYCYRKLQKVAITGGKKglRKPSLEEVDH 861
Cdd:pfam00784   73 ------------------------EVGKYAQFCLKRLKRTLKNGGRK--YPPSREEIEA 105
MyTH4 smart00139
Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 ...
 675-859 2.65e-30

Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 214535  Cd Length: 152  Bit Score: 117.08  E-value: 2.65e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514     675 WNRGSIKKPMLMTNDRTVRKEACEMFKLVQAYMGDRPSRLDRRHAALL--IVTKCWGMQGLRDELYVQLVRQTTGNTSPR 752
Cdd:smart00139    1 YTKDPIKTSLLKLESDELQKEAVKIFKAILKFMGDIPLPRPDSHLDLVqfILQKGLDHPELRDEIYCQLIKQLTDNPSRQ 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514     753 SLAAGWELMAVCLAFFAPSPKFCCYLEGYIQRHIEPtndkkitqfildqqdskkknsksrkkrkqnsdeeaeaLPISTYA 832
Cdd:smart00139   81 SEERGWQLLYLCTSLFPPSERLLPYLLQFLSRRADP-------------------------------------GSEQGLA 123

                           170       180
                    ....*....|....*....|....*..
gi 55925514     833 KYCYRKLQKVAITGGKKglRKPSLEEV 859
Cdd:smart00139  124 KYCLYRLERTLKNGARK--QPPSRLEL 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 908-1057 1.68e-28

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 112.74  E-value: 1.68e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514     908 GAQTEGIFRVPGDIDEVNALKLQVDQWRIP---ENLSDPNVPASLMKLWYRELEEPLIPMTFYKHC--VSNYDDPAAAIS 982
Cdd:smart00324   18 GLDTEGIYRVSGSKSRVKELRDAFDSGPDPdldLSEYDVHDVAGLLKLFLRELPEPLITYELYEEFieAAKLEDETERLR 97

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55925514     983 ----VVQSLPELNRLVLSYFIHFLQVFAQpsNVSVTKMDVNNLAMVMAPNCLRCQSDDPRVIFENTRKeMSFLRMLIVH 1057
Cdd:smart00324   98 alreLLSLLPPANRATLRYLLAHLNRVAE--HSEENKMTARNLAIVFGPTLLRPPDGEVASLKDIRHQ-NTVIEFLIEN 173
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 871-1057 4.94e-22

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 95.20  E-value: 4.94e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  871 LFGSSLEEVM--ERQselFPDRKLPWVQVQLSQYVLAlGGAQTEGIFRVPGDIDEVNALKLQVDQWRIPENLSDPNVP-- 946
Cdd:cd04390    2 VFGQRLEDTVayERK---FGPRLVPILVEQCVDFIRE-HGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHtv 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  947 ASLMKLWYRELEEPLIPMTFYKHCVS-----NYDDPAAAISV---VQSLPELNRLVLSYFIHFLqvFAQPSNVSVTKMDV 1018
Cdd:cd04390   78 ASLLKLYLRELPEPVIPWAQYEDFLScaqllSKDEEKGLGELmkqVSILPKVNYNLLSYICRFL--DEVQSNSSVNKMSV 155

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 55925514 1019 NNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRMLIVH 1057
Cdd:cd04390  156 QNLATVFGPNILRPKVEDPATIMEGTPQIQQLMTVMISK 194
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 872-1062 2.03e-21

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 93.17  E-value: 2.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  872 FGSSLEEVMERQSELFPdrkLPWVQVQLSQYvLALGGAQTEGIFRVPGDIDEVNALKLQVDQwRIPENLS---DPNVPAS 948
Cdd:cd04404    6 FGVSLQFLKEKNPEQEP---IPPVVRETVEY-LQAHALTTEGIFRRSANTQVVKEVQQKYNM-GEPVDFDqyeDVHLPAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  949 LMKLWYRELEEPLipMTF--YKHCV-----SNYDDPAAAISVVQSLPELNRLVLSYFIHFLQVFAQPSnvSVTKMDVNNL 1021
Cdd:cd04404   81 ILKTFLRELPEPL--LTFdlYDDIVgflnvDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHS--DQNKMTNSNL 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 55925514 1022 AMVMAPNCLRCQSDdprvifENTRKEM----SFLRMLIVHLDTSF 1062
Cdd:cd04404  157 AVVFGPNLLWAKDA------SMSLSAInpinTFTKFLLDHQDEIF 195
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 871-1035 2.67e-19

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 86.75  E-value: 2.67e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  871 LFGSSLEEVmerQSELFPDRKLPWVQVQLSQYvLALGGAQTEGIFRVPGDIDEVNALKLQVDQWRIPENLSDPNVP--AS 948
Cdd:cd04393    2 VFGVPLQEL---QQAGQPENGVPAVVRHIVEY-LEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCsaAS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  949 LMKLWYRELEEPLIPMTFYKHCVSNYDDPAA-------AISVVQSLPELNRLVLSYFIHFLQVFAqpSNVSVTKMDVNNL 1021
Cdd:cd04393   78 LLRLFLQELPEGLIPASLQIRLMQLYQDYNGedefgrkLRDLLQQLPPVNYSLLKFLCHFLSNVA--SQHHENRMTAENL 155

                        170
                 ....*....|....
gi 55925514 1022 AMVMAPNCLRCQSD 1035
Cdd:cd04393  156 AAVFGPDVFHVYTD 169
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 870-1066 5.98e-19

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 86.36  E-value: 5.98e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  870 SLFGSSLEEVMERQselfpDRKLPWVqVQLSQYVLALGGAQTEGIFRVPGDIDEVNALKLQVD----QWRIPENLSDPNV 945
Cdd:cd04386    3 PVFGTPLEEHLKRT-----GREIALP-IEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDagtfSLPLDEFYSDPHA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  946 PASLMKLWYRELEEPLIPMTFYKHCV--SNYDDPA---AAI-SVVQSLPELNRLVLSYFIHFLQVFAQPSNvsVTKMDVN 1019
Cdd:cd04386   77 VASALKSYLRELPDPLLTYNLYEDWVqaANKPDEDerlQAIwRILNKLPRENRDNLRYLIKFLSKLAQKSD--ENKMSPS 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 55925514 1020 NLAMVMAPNCLrcqsddpRVIFENTRKEM---------SFLRMLIVHLDTSFIEGV 1066
Cdd:cd04386  155 NIAIVLAPNLL-------WAKNEGSLAEMaagtsvhvvAIVELIISHADWFFPGEV 203
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 872-1036 9.27e-18

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 82.45  E-value: 9.27e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  872 FGSSLEEVMERQSELFPdrklpwVQVQLSQYVLALGGAQTEGIFRVPGDIDEVNALKLQVDQ-------WRIPENLSDPN 944
Cdd:cd04398    1 FGVPLEDLILREGDNVP------NIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKdplnvllISPEDYESDIH 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  945 VPASLMKLWYRELEEPLIPMTFYKH---CVSNYDDPAAAISV---VQSLPELNRLVLSYFIHFLQVFAQpsNVSVTKMDV 1018
Cdd:cd04398   75 SVASLLKLFFRELPEPLLTKALSREfieAAKIEDESRRRDALhglINDLPDANYATLRALMFHLARIKE--HESVNRMSV 152

                        170
                 ....*....|....*...
gi 55925514 1019 NNLAMVMAPNCLRCQSDD 1036
Cdd:cd04398  153 NNLAIIWGPTLMNAAPDN 170
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 871-1038 1.23e-17

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 82.78  E-value: 1.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  871 LFGSSLEEVMERQSELFPDRKLPWV-QVQLSQyvLALGGAQTEGIFRVPGDIDEVNALKLQVD----QWRIPENLSDPNV 945
Cdd:cd04391    1 LFGVPLSTLLERDQKKVPGSKVPLIfQKLINK--LEERGLETEGILRIPGSAQRVKFLCQELEakfyEGTFLWDQVKQHD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  946 PASLMKLWYRELEEPLIPM----TFYK-HCVSNYDDPAAAISV-VQSLPELNRLVLSYFIHFLQ--VFAQPSNvsvtKMD 1017
Cdd:cd04391   79 AASLLKLFIRELPQPLLTVeylpAFYSvQGLPSKKDQLQALNLlVLLLPEANRDTLKALLEFLQkvVDHEEKN----KMN 154

                        170       180
                 ....*....|....*....|.
gi 55925514 1018 VNNLAMVMAPNCLRCQSDDPR 1038
Cdd:cd04391  155 LWNVAMIMAPNLFPPRGKHSK 175
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 908-1027 1.68e-16

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 78.87  E-value: 1.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  908 GAQTEGIFRVPGDIDEVNALKLQVDQWRIPENLSDPNVPA--SLMKLWYRELEEPLIPMTFYK---HCVSNYDDP---AA 979
Cdd:cd04382   32 GLTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSKVDIHVicGCLKDFLRSLKEPLITFALWKefmEAAEILDEDnsrAA 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 55925514  980 AISVVQSLPELNRLVLSYFIHFLQVFAQpsnVSVTKMDVNNLAMVMAP 1027
Cdd:cd04382  112 LYQAISELPQPNRDTLAFLILHLQRVAQ---SPECKMDINNLARVFGP 156
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 892-1055 1.16e-15

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 76.74  E-value: 1.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  892 LPWVQVQLSQYVLAlgGAQTEGIFRVPGDIDEVNALKLQVDQWRIPENLSDPNVPASLMKLWYRELEEPLIPM----TFY 967
Cdd:cd04394   20 VPKFLVDACTFLLD--HLSTEGLFRKSGSVVRQKELKAKLEGGEACLSSALPCDVAGLLKQFFRELPEPLLPYdlheALL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  968 K--HCVSNYDDPAAAISVVQSLPELNRLVLSYFIHFLQVFAQPSnvSVTKMDVNNLAMVMAPNCLRCQSDDPRVIFEN-- 1043
Cdd:cd04394   98 KaqELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRC--SENKMDSSNLAVIFAPNLFQSEEGGEKMSSSTek 175

                        170
                 ....*....|...
gi 55925514 1044 -TRKEMSFLRMLI 1055
Cdd:cd04394  176 rLRLQAAVVQTLI 188
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 908-1031 3.56e-15

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 75.35  E-value: 3.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  908 GAQTEGIFRVPGDIDEVNALK--LQVDQWRIPENLS--DPNVPASLMKLWYRELEEPLIPMTFYKHCVSNYD--DPAAA- 980
Cdd:cd04387   31 GMEEVGIYRISGVATDIQALKaaFDTNNKDVSVMLSemDVNAIAGTLKLYFRELPEPLFTDELYPNFAEGIAlsDPVAKe 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 55925514  981 ---ISVVQSLPELNRLVLSYFIHFLQVFAQpsNVSVTKMDVNNLAMVMAPNCLR 1031
Cdd:cd04387  111 scmLNLLLSLPDPNLVTFLFLLHHLKRVAE--REEVNKMSLHNLATVFGPTLLR 162
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 870-1057 1.32e-14

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 73.22  E-value: 1.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  870 SLFGSSLEEVMERQSELFPdrklpwVQVQLSQYVLALGGAQTEGIFRVPGDIDEVNALK---------LQVDQwripeNL 940
Cdd:cd04383    1 KLFNGSLEEYIQDSGQAIP------LVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKnafergedpLADDQ-----ND 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  941 SDPNVPASLMKLWYRELEEPLIPMTFYKHCVS--NYDDPAAAIS----VVQSLPELNRLVLSYFIHFLQVFAQPSNVSVt 1014
Cdd:cd04383   70 HDINSVAGVLKLYFRGLENPLFPKERFEDLMScvKLENPTERVHqireILSTLPRSVIIVMRYLFAFLNHLSQFSDENM- 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 55925514 1015 kMDVNNLAMVMAPNCLRCQSDDPRVIFENTRKEMsfLRMLIVH 1057
Cdd:cd04383  149 -MDPYNLAICFGPTLMPVPEGQDQVSCQAHVNEL--IKTIIIH 188
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 871-1027 2.24e-14

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 72.78  E-value: 2.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  871 LFGSSLEEVMERQSELFPDRKLPWVQVQLSQYVLALGGAQTEGIFRVPGDIDEVNALKLQ------VDQWRIPENLsDPN 944
Cdd:cd04400    1 IFGSPLEEAVELSSHKYNGRDLPSVVYRCIEYLDKNRAIYEEGIFRLSGSASVIKQLKERfnteydVDLFSSSLYP-DVH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  945 VPASLMKLWYRELEEPLIPMTFY---KHCVSNYDDPAAAI----SVVQSLPELNRLVLSYFIHFLQVFAQPSNVSvtKMD 1017
Cdd:cd04400   80 TVAGLLKLYLRELPTLILGGELHndfKRLVEENHDRSQRAlelkDLVSQLPQANYDLLYVLFSFLRKIIEHSDVN--KMN 157

                        170
                 ....*....|
gi 55925514 1018 VNNLAMVMAP 1027
Cdd:cd04400  158 LRNVCIVFSP 167
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 889-1056 2.26e-14

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 72.47  E-value: 2.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  889 DRKLPWVQVQLSQYVlALGGAQTEGIFRVPGDIDEVNALKLQVDQWRIPENLSDPNVP--ASLMKLWYRELEEPLIPMTF 966
Cdd:cd04377   12 DRSVPLVLEKLLEHI-EMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNLEDYPIHviTSVLKQWLRELPEPLMTFEL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  967 YKHC--VSNYDDP----AAAISVVQSLPELNRLVLSYFI-HFLQVFAQPSnvsVTKMDVNNLAMVMAPNCLRCQ-SDDPR 1038
Cdd:cd04377   91 YENFlrAMELEEKqervRALYSVLEQLPRANLNTLERLIfHLVRVALQEE---VNRMSANALAIVFAPCILRCPdTADPL 167

                        170
                 ....*....|....*...
gi 55925514 1039 VIFENTRKEMSFLRMLIV 1056
Cdd:cd04377  168 QSLQDVSKTTTCVETLIK 185
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 908-1062 4.69e-14

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 71.78  E-value: 4.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  908 GAQTEGIFRVPGDIDEVNALKLQVDQWRIPENLS-----DPNVPASLMKLWYRELEEPLIPMTFYKHCV-----SNYDDP 977
Cdd:cd04372   31 GLQSEGLYRVSGFAEEIEDVKMAFDRDGEKADISatvypDINVITGALKLYFRDLPIPVITYDTYPKFIdaakiSNPDER 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  978 AAAIS-VVQSLPELNRLVLSYFIHFLQVFAQpsNVSVTKMDVNNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRMLIV 1056
Cdd:cd04372  111 LEAVHeALMLLPPAHYETLRYLMEHLKRVTL--HEKDNKMNAENLGIVFGPTLMRPPEDSALTTLNDMRYQILIVQLLIT 188


                 ....*.
gi 55925514 1057 HLDTSF 1062
Cdd:cd04372  189 NEDVLF 194
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 892-1056 8.40e-14

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 70.79  E-value: 8.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  892 LPWVQVQLSQYVlALGGAQTEGIFRVPGDIDEVNALK--LQVDqwriPENLSDPNVP----ASLMKLWYRELEEPLIPMT 965
Cdd:cd04407   15 VPIVLEKLLEHV-EMHGLYTEGIYRKSGSANRMKELHqlLQAD----PENVKLENYPihaiTGLLKQWLRELPEPLMTFA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  966 FYKHCVSNYDDP------AAAISVVQSLPELNRLVLSYFIHFLQVFAQPSNVSvtKMDVNNLAMVMAPNCLRC-QSDDPR 1038
Cdd:cd04407   90 QYNDFLRAVELPekqeqlQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVN--RMSPNALAIVFAPCLLRCpDSSDPL 167

                        170
                 ....*....|....*...
gi 55925514 1039 VIFENTRKEMSFLRMLIV 1056
Cdd:cd04407  168 TSMKDVAKTTTCVEMLIK 185
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 908-1062 1.26e-13

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 70.51  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  908 GAQTEGIFRVPGDIDEVNALKLQVDQWRIPENLSDP-----NVPASLMKLWYRELEEPLIPMTFYKHCV--SNYDDPAAA 980
Cdd:cd04395   33 GLETVGIYRVPGNNAAISALQEELNRGGFDIDLQDPrwrdvNVVSSLLKSFFRKLPEPLFTNELYPDFIeaNRIEDPVER 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  981 I----SVVQSLPELNRLVLSYFIHFLQVFAqpSNVSVTKMDVNNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRMLIV 1056
Cdd:cd04395  113 LkelrRLIHSLPDHHYETLKHLIRHLKTVA--DNSEVNKMEPRNLAIVFGPTLVRTSDDNMETMVTHMPDQCKIVETLIQ 190


                 ....*.
gi 55925514 1057 HLDTSF 1062
Cdd:cd04395  191 HYDWFF 196
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 872-1027 1.66e-13

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 69.77  E-value: 1.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  872 FGSSLEEVMERqSELFPDRKLPWVQVQLSQYVLALGgAQTEGIFRVPGDIDEVNALKLQVDQWRIPeNLSD--PNVPASL 949
Cdd:cd04381    1 FGASLSLAVER-SRCHDGIDLPLVFRECIDYVEKHG-MKCEGIYKVSGIKSKVDELKAAYNRRESP-NLEEyePPTVASL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  950 MKLWYRELEEPLipmtFYKHCVSNYDDPAAAISV----------VQSLPELNRLVLSYFI-HFLQVFAQPSNvsvTKMDV 1018
Cdd:cd04381   78 LKQYLRELPEPL----LTKELMPRFEEACGRPTEaereqelqrlLKELPECNRLLLAWLIvHMDHVIAQELE---TKMNI 150


                 ....*....
gi 55925514 1019 NNLAMVMAP 1027
Cdd:cd04381  151 QNISIVLSP 159
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 872-1031 1.10e-12

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 67.80  E-value: 1.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  872 FGSSLEEVMERQSELFPDRklpwvqVQLSQYVLALGGAQTEGIFRVPGDIDEVNALKLQVDQWR-IPENLS---DPNVPA 947
Cdd:cd04403    1 FGCHLEALCQRENSTVPKF------VRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEkLDLDDSkweDIHVIT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  948 SLMKLWYRELEEPLIPMTFYKHCV-----SNYDDPAAAI-SVVQSLPELNRLVLSY-FIHFLQVFAqpsNVSVTKMDVNN 1020
Cdd:cd04403   75 GALKLFFRELPEPLFPYSLFNDFVaaiklSDYEQRVSAVkDLIKSLPKPNHDTLKMlFRHLCRVIE---HGEKNRMTTQN 151

                        170
                 ....*....|.
gi 55925514 1021 LAMVMAPNCLR 1031
Cdd:cd04403  152 LAIVFGPTLLR 162
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 912-1058 2.08e-12

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 67.39  E-value: 2.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  912 EGIFRVPGDIDEVNALKLQVD-QWRIPENLSDPNVP--ASLMKLWYRELEEPLIPMTFYKHCVS--NYDDPAAAISVVQ- 985
Cdd:cd04397   46 EGVFRKNGNIRRLKELTEEIDkNPTEVPDLSKENPVqlAALLKKFLRELPDPLLTFKLYRLWISsqKIEDEEERKRVLHl 125

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55925514  986 ---SLPELNR---LVLSYFIHFLQVFAQPSNVSVTKMDVNNLAMVMAPNCLRCQSDDPrvifeNTRKEmSFLRMLIVHL 1058
Cdd:cd04397  126 vycLLPKYHRdtmEVLFSFLKWVSSFSHIDEETGSKMDIHNLATVITPNILYSKTDNP-----NTGDE-YFLAIEAVNY 198
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 871-1057 5.29e-12

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 65.78  E-value: 5.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  871 LFGSSLeevmerqSELFPDRKLPW-VQVQLSqyVLALGGAQTEGIFRVPGDIDEVNALKLQVDQWRIPeNLSDPNVP--A 947
Cdd:cd04402    1 LFGQPL-------SNICEDDNLPKpILDMLS--LLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEV-DLKAEPVLllA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  948 SLMKLWYRELEEPLIPMTFYKHCVSNYDDP------AAAISVVQSLPELNRLVLSYFIHFLQVFAQPSNVSvtKMDVNNL 1021
Cdd:cd04402   71 SVLKDFLRNIPGSLLSSDLYEEWMSALDQEneeekiAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETN--KMDAFNL 148

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 55925514 1022 AMVMAPNCLrCQSDDPRVIFENTRKEMSFLRMLIVH 1057
Cdd:cd04402  149 AVCIAPSLL-WPPASSELQNEDLKKVTSLVQFLIEN 183
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 908-1062 1.93e-10

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 61.69  E-value: 1.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  908 GAQTEGIFRVPGDIDEVNALKLQVDQWR---IPENLSDPNVpASLMKLWYRELEEPLIPMTFYKHCVS----NYDDPAAA 980
Cdd:cd04376   24 GLQTVGIFRVGSSKKRVRQLREEFDRGIdvvLDENHSVHDV-AALLKEFFRDMPDPLLPRELYTAFIGtallEPDEQLEA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  981 IS-VVQSLPELNRLVLSYFIHFLQVFAQPSN---------VSVTKMDVNNLAMVMAPNCLRCQSDDPRVI------FENT 1044
Cdd:cd04376  103 LQlLIYLLPPCNCDTLHRLLKFLHTVAEHAAdsidedgqeVSGNKMTSLNLATIFGPNLLHKQKSGEREFvqaslrIEES 182

                        170
                 ....*....|....*...
gi 55925514 1045 RKEMSFLRMLIVHLDTSF 1062
Cdd:cd04376  183 TAIINVVQTMIDNYEELF 200
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 883-1031 1.11e-09

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 59.01  E-value: 1.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  883 QSELFPDRKLPWVQVQLSQYVLAlGGAQTEGIFRVPGDIDEVNALKLQVDQWR---IPENLSDPNVPASLMKLWYRELEE 959
Cdd:cd04373    6 ANVVTSEKPIPIFLEKCVEFIEA-TGLETEGIYRVSGNKTHLDSLQKQFDQDHnldLVSKDFTVNAVAGALKSFFSELPD 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55925514  960 PLIPMTFYKHCVSNY---DDPA---AAISVVQSLPELNRLVLSYFIHFLQVFAQPSNVSVtkMDVNNLAMVMAPNCLR 1031
Cdd:cd04373   85 PLIPYSMHLELVEAAkinDREQrlhALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNL--MTSENLSICFWPTLMR 160
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 889-1056 1.55e-08

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 55.78  E-value: 1.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  889 DRKLPWVQVQLSQYVlALGGAQTEGIFRVPGDIDEVNALKLQVDQWRIPENLSDPN--VPASLMKLWYRELEEPLIPMTF 966
Cdd:cd04406   12 DRSVPLVVEKLINYI-EMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDYNihVIASVFKQWLRDLPNPLMTFEL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  967 YKH---CVSNYDDPAAAISVVQSLPELNRLVLSYF----IHFLQVFAQPsnvSVTKMDVNNLAMVMAPNCLRC-QSDDPR 1038
Cdd:cd04406   91 YEEflrAMGLQERRETVRGVYSVIDQLSRTHLNTLerliFHLVRIALQE---ETNRMSANALAIVFAPCILRCpDTTDPL 167

                        170
                 ....*....|....*...
gi 55925514 1039 VIFENTRKEMSFLRMLIV 1056
Cdd:cd04406  168 QSVQDISKTTTCVELIVC 185
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 864-1052 3.09e-08

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 55.42  E-value: 3.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  864 RAILTPSLFGSSLEEV--MERQSELFPDRKLPWVQVQLSQYV--------------LALGGAQTEGIFRVPGDIDEVNAL 927
Cdd:cd04380    5 TGVYLPSCFGSSLETLirLPDPGIRNLIDQLELGDNPDYSEVplsipkeiwrlvdyLYTRGLAQEGLFEEPGLPSEPGEL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  928 KLQV----DQWRIPENLSDPNVPASLMKLWYRELEEPLIPMTFYKHCV----SNYDDPAAAISvvQSLPELNRLVLSYFI 999
Cdd:cd04380   85 LAEIrdalDTGSPFNSPGSAESVAEALLLFLESLPDPIIPYSLYERLLeavaNNEEDKRQVIR--ISLPPVHRNVFVYLC 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 55925514 1000 HFLQVFAQPSNVSvtKMDVNNLAMVMAPNCLRCQSDDPRVIFENTRKEMS-----FLR 1052
Cdd:cd04380  163 SFLRELLSESADR--GLDENTLATIFGRVLLRDPPRAGGKERRAERDRKRafieqFLL 218
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 870-1031 5.19e-08

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 54.43  E-value: 5.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  870 SLFGSSLEEVMERQSElfpdrKLPWVQVQLSQYVLALGgaQTEGIFRVPGDIDEVNALKLQVDQWRIP-----ENLSDPN 944
Cdd:cd04384    1 RVFGCDLTEHLLNSGQ-----DVPQVLKSCTEFIEKHG--IVDGIYRLSGIASNIQRLRHEFDSEQIPdltkdVYIQDIH 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  945 VPASLMKLWYRELEEPLIPMTFYKH---CVSNYDDPAAAIS---VVQSLPELNRLVLSYFIHFLQVFAQPSnvSVTKMDV 1018
Cdd:cd04384   74 SVSSLCKLYFRELPNPLLTYQLYEKfseAVSAASDEERLEKihdVIQQLPPPHYRTLEFLMRHLSRLAKYC--SITNMHA 151

                        170
                 ....*....|...
gi 55925514 1019 NNLAMVMAPNCLR 1031
Cdd:cd04384  152 KNLAIVWAPNLLR 164
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 913-1027 1.83e-07

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 53.19  E-value: 1.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  913 GIFRVPGDIDEVNALKLQVDQWRIPENLSDPNV--PASLMKLWYRELEEPLIPM----TF---YKHcVSNYDDPAAAISV 983
Cdd:cd04375   40 GLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAydVADMLKQYFRDLPEPLLTNklseTFiaiFQY-VPKEQRLEAVQCA 118

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 55925514  984 VQSLPELNRLVLSYFIHFLQVFAqpSNVSVTKMDVNNLAMVMAP 1027
Cdd:cd04375  119 ILLLPDENREVLQTLLYFLSDVA--ANSQENQMTATNLAVCLAP 160
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 911-1057 1.09e-06

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 50.54  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  911 TEGIFRVPGDIDEVNALKLQVDQWR-IPENLSD--PNVPASLMKLWYRELEEPLIPMTFY-KHC----VSNYDDPAAAIS 982
Cdd:cd04392   26 VEGLFRKPGNSARQQELRDLLNSGTdLDLESGGfhAHDCATVLKGFLGELPEPLLTHAHYpAHLqiadLCQFDEKGNKTS 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  983 VVQS-------------LPELNRLVLSYFIHFLQVFAQPSnvSVTKMDVNNLAMVMAPNCLRCQSDDPRVIFENTRKEMS 1049
Cdd:cd04392  106 APDKerllealqlllllLPEENRNLLKLILDLLYQTAKHE--DKNKMSADNLALLFTPHLICPRNLTPEDLHENAQKLNS 183


                 ....*...
gi 55925514 1050 FLRMLIVH 1057
Cdd:cd04392  184 IVTFMIKH 191
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 871-1059 2.00e-06

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 50.10  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  871 LFGSSLEE----------VMERQSELFPDRKLPWVQVQLSQYvLALGGAQTEGIFRVPGDIDEVNALKLQVDQwrIPE-- 938
Cdd:cd04396    1 VFGVSLEEslkyasvaisIVDEDGEQYVYGYIPVVVAKCGVY-LKENATEVEGIFRVAGSSKRIRELQLIFST--PPDyg 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  939 ---NLSDPNV--PASLMKLWYRELEEPLIPMTFY-------------------KHCVSNYDDPAAAIS----VVQSLPEL 990
Cdd:cd04396   78 ksfDWDGYTVhdAASVLRRYLNNLPEPLVPLDLYeefrnplrkrprilqymkgRINEPLNTDIDQAIKeyrdLITRLPNL 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55925514  991 NRLVLSYFIHFLQVFAqpSNVSVTKMDVNNLAMVMAPNCLRCQSDDprVIFENTRKEMSFLRMLIVHLD 1059
Cdd:cd04396  158 NRQLLLYLLDLLAVFA--RNSDKNLMTASNLAAIFQPGILSHPDHE--MDPKEYKLSRLVVEFLIEHQD 222
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 872-1038 6.02e-06

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 48.23  E-value: 6.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  872 FGSSLEEVMERQSelfPDRKLPWVQVQLSQYVlALGGAQTEGIFRVPGDI-------DEVNALKLQVDQwrIPENLSDPN 944
Cdd:cd04379    1 FGVPLSRLVEREG---ESRDVPIVLQKCVQEI-ERRGLDVIGLYRLCGSAakkkelrDAFERNSAAVEL--SEELYPDIN 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  945 VPASLMKLWYRELEEPLIPMTFYKH-----CVSNYDDPAA----AISVVQSLPELNRLVLSYFIHFLQVFAqpSNVSVTK 1015
Cdd:cd04379   75 VITGVLKDYLRELPEPLITPQLYEMvlealAVALPNDVQTnthlTLSIIDCLPLSAKATLLLLLDHLSLVL--SNSERNK 152

                        170       180
                 ....*....|....*....|...
gi 55925514 1016 MDVNNLAMVMAPNCLRCQSDDPR 1038
Cdd:cd04379  153 MTPQNLAVCFGPVLMFCSQEFSR 175
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 908-1057 4.21e-05

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 45.38  E-value: 4.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  908 GAQTEGIFRVPGDIDEVNAL--KLQVD----QWRIPENlsDPNVPASLMKLWYRELEEPLIPMT---FYKHCVSNYDDP- 977
Cdd:cd04385   30 GLMSEGIYRKNGKNSSVKKLleAFRKDarsvQLREGEY--TVHDVADVLKRFLRDLPDPLLTSElhaEWIEAAELENKDe 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  978 -----AAAISvvqSLPELNRLVLSYFIHFLQVFAQPSNVSvtKMDVNNLAMVMAPnCLrCQSDDPRVifENTRKEMSFLR 1052
Cdd:cd04385  108 riaryKELIR---RLPPINRATLKVLIGHLYRVQKHSDEN--QMSVHNLALVFGP-TL-FQTDEHSV--GQTSHEVKVIE 178


                 ....*
gi 55925514 1053 MLIVH 1057
Cdd:cd04385  179 DLIDN 183
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 905-1031 3.09e-04

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 43.18  E-value: 3.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  905 ALGgaqTEGIFRVPGDIDEVNAL-------KLQVDqwripenLSD--PNVPASLMKLWYRELEEPLIPMTFYKHCVS--- 972
Cdd:cd04378   31 ALG---VQGIYRVSGSKARVEKLcqafengKDLVE-------LSElsPHDISSVLKLFLRQLPEPLILFRLYNDFIAlak 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 55925514  973 -----NYDDPAAAI-----SVVQSLPEL-------NRLVLSYFI-HFLQVFAQPSNvsvTKMDVNNLAMVMAPNCLR 1031
Cdd:cd04378  101 eiqrdTEEDKAPNTpievnRIIRKLKDLlrqlpasNYNTLQHLIaHLYRVAEQFEE---NKMSPNNLGIVFGPTLIR 174
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 887-1031 3.52e-04

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 42.88  E-value: 3.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  887 FPDrKLPWVQVQLSQYV--LALGgaqTEGIFRVPGDIDEVNALKLQVDQWRIPENLSD--PNVPASLMKLWYRELEEPLI 962
Cdd:cd04408   12 FPE-EVPFVVVRCTAEIenRALG---VQGIYRISGSKARVEKLCQAFENGRDLVDLSGhsPHDITSVLKHFLKELPEPVL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925514  963 PMTFYKHCVS-----------NYDDPAAAISVVQSLPEL-NRLVLSYFIHFLQVFAQPSNVSV----TKMDVNNLAMVMA 1026
Cdd:cd04408   88 PFQLYDDFIAlakelqrdsekAAESPSIVENIIRSLKELlGRLPVSNYNTLRHLMAHLYRVAErfedNKMSPNNLGIVFG 167


                 ....*
gi 55925514 1027 PNCLR 1031
Cdd:cd04408  168 PTLLR 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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