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Conserved domains on  [gi|55925516|ref|NP_001007295|]
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ankyrin repeat domain-containing protein 9 [Danio rerio]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 12158766)

ankyrin repeat (ANK) domain-containing protein mediates specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

CATH:  1.25.40.20
Gene Ontology:  GO:0005515
PubMed:  33435370|15152081|17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
108-188 7.51e-06

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.49  E-value: 7.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925516 108 LSIAVRYNRINILKMMmetIKELADCEKQsflNRHGcvhtdgsKTALHLACDLVRPECLILLLGHGACPYVTDLTGNTPL 187
Cdd:COG0666 157 LHLAAANGNLEIVKLL---LEAGADVNAR---DNDG-------ETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223


                .
gi 55925516 188 D 188
Cdd:COG0666 224 D 224
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
108-188 7.51e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.49  E-value: 7.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925516 108 LSIAVRYNRINILKMMmetIKELADCEKQsflNRHGcvhtdgsKTALHLACDLVRPECLILLLGHGACPYVTDLTGNTPL 187
Cdd:COG0666 157 LHLAAANGNLEIVKLL---LEAGADVNAR---DNDG-------ETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223


                .
gi 55925516 188 D 188
Cdd:COG0666 224 D 224
Ank_5 pfam13857
Ankyrin repeats (many copies);
139-188 1.92e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 1.92e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 55925516   139 LNRHG---CVHTDGSK-TALHLACDLVRPECLILLLGHGACPYVTDLTGNTPLD 188
Cdd:pfam13857   1 LLEHGpidLNRLDGEGyTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 144-188 2.10e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 2.10e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 55925516  144 CVHTDGSkTALHLACDLVRPECLILLLGHGACPYVTDLTGNTPLD 188
Cdd:PTZ00322 110 CRDYDGR-TPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLE 153
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
108-188 7.51e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.49  E-value: 7.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925516 108 LSIAVRYNRINILKMMmetIKELADCEKQsflNRHGcvhtdgsKTALHLACDLVRPECLILLLGHGACPYVTDLTGNTPL 187
Cdd:COG0666 157 LHLAAANGNLEIVKLL---LEAGADVNAR---DNDG-------ETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223


                .
gi 55925516 188 D 188
Cdd:COG0666 224 D 224
Ank_5 pfam13857
Ankyrin repeats (many copies);
139-188 1.92e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 1.92e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 55925516   139 LNRHG---CVHTDGSK-TALHLACDLVRPECLILLLGHGACPYVTDLTGNTPLD 188
Cdd:pfam13857   1 LLEHGpidLNRLDGEGyTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
108-187 2.56e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.86  E-value: 2.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925516 108 LSIAVRYNRINILKMMmetIKELADCEKQsflNRHGcvhtdgsKTALHLACDLVRPECLILLLGHGACPYVTDLTGNTPL 187
Cdd:COG0666  91 LHAAARNGDLEIVKLL---LEAGADVNAR---DKDG-------ETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
108-187 2.56e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.86  E-value: 2.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925516 108 LSIAVRYNRINILKMMmetIKELADCEKQsflNRHGcvhtdgsKTALHLACDLVRPECLILLLGHGACPYVTDLTGNTPL 187
Cdd:COG0666 124 LHLAAYNGNLEIVKLL---LEAGADVNAQ---DNDG-------NTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL 190
Ank_2 pfam12796
Ankyrin repeats (3 copies);
108-180 1.01e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.40  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925516   108 LSIAVRYNRINILKMMMETIKE--LADCEKQSFL------NRHGCV----------HTDGSKTALHLACDLVRPECLILL 169
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADanLQDKNGRTALhlaaknGHLEIVklllehadvnLKDNGRTALHYAARSGHLEIVKLL 80

                          90
                  ....*....|.
gi 55925516   170 LGHGACPYVTD 180
Cdd:pfam12796  81 LEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 144-188 2.10e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 2.10e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 55925516  144 CVHTDGSkTALHLACDLVRPECLILLLGHGACPYVTDLTGNTPLD 188
Cdd:PTZ00322 110 CRDYDGR-TPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLE 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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