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Conserved domains on  [gi|56605936|ref|NP_001007267|]
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trace amine-associated receptor 2 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11607336)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
33-314 1.22e-177

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


:

Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 493.41  E-value: 1.22e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15312   2 AMYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVM 192
Cdd:cd15312  82 MLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVFSEVNLEGIEDYVALVSCTGSCVLI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMR------KDKKAAKTLGIVMGVFLLCWFPC 266
Cdd:cd15312 162 FNKLWGVIASLIAFFIPGTVMIGIYIKIFFVARKHAKVINNRPSVTKGDSKnklskkKERKAAKTLSIVMGVFLLCWLPF 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56605936 267 FFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15312 242 FVATLIDPFLNFSTPVDLFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
 
Name Accession Description Interval E-value
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
33-314 1.22e-177

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 493.41  E-value: 1.22e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15312   2 AMYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVM 192
Cdd:cd15312  82 MLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVFSEVNLEGIEDYVALVSCTGSCVLI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMR------KDKKAAKTLGIVMGVFLLCWFPC 266
Cdd:cd15312 162 FNKLWGVIASLIAFFIPGTVMIGIYIKIFFVARKHAKVINNRPSVTKGDSKnklskkKERKAAKTLSIVMGVFLLCWLPF 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56605936 267 FFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15312 242 FVATLIDPFLNFSTPVDLFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
48-303 1.86e-46

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 158.23  E-value: 1.86e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936    48 GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENC-WYFGLTFCKIHYSFDLMLSITSIFHLCSVA 126
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGdWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936   127 VDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgAFAFGVVFSEAYADGIEGYDILVACSSSCP--VMFNKLWGTTLFVA 204
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVL--ALLLSLPPLLFGWTLTVPEGNVTVCFIDFPedLSKPVSYTLLISVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936   205 GFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQnnqmrKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLNFSTPA-- 282
Cdd:pfam00001 159 GFLLPLLVILVCYTLIIRTLRKSASKQKSSERTQ-----RRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSrl 233
                         250       260
                  ....*....|....*....|...
gi 56605936   283 --VLFDALTWFGYFNSTCNPLIY 303
Cdd:pfam00001 234 ldKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
43-265 1.29e-08

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 55.55  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936   43 FITIFGNLAMIISISYFKqLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:PHA03087  52 FFGLVGNIIVIYVLTKTK-IKTPMDIYLLNLAVSDLLFVMT-LPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFI 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYAdgiEGYDILVACSS-SCPVMFNKLWGTTL 201
Cdd:PHA03087 130 TVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTK---KDHETLICCMFyNNKTMNWKLFINFE 206
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56605936  202 F-VAGFFTPSSMMVGIYGKIFAVSKKHarvidnlpenqnNQMRKDKKAAKTLGIVMGVFLLCWFP 265
Cdd:PHA03087 207 InIIGMLIPLTILLYCYSKILITLKGI------------NKSKKNKKAIKLVLIIVILFVIFWLP 259
 
Name Accession Description Interval E-value
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
33-314 1.22e-177

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 493.41  E-value: 1.22e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15312   2 AMYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVM 192
Cdd:cd15312  82 MLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVFSEVNLEGIEDYVALVSCTGSCVLI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMR------KDKKAAKTLGIVMGVFLLCWFPC 266
Cdd:cd15312 162 FNKLWGVIASLIAFFIPGTVMIGIYIKIFFVARKHAKVINNRPSVTKGDSKnklskkKERKAAKTLSIVMGVFLLCWLPF 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56605936 267 FFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15312 242 FVATLIDPFLNFSTPVDLFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
34-314 1.03e-138

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 394.61  E-value: 1.03e-138
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLM 113
Cdd:cd15055   3 LYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDilvACSSSCPVMF 193
Cdd:cd15055  83 LTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQPGLIRYN---SCYGECVVVV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 194 NKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQ-------MRKDKKAAKTLGIVMGVFLLCWFPC 266
Cdd:cd15055 160 NFIWGVVDLVLTFILPCTVMIVLYMRIFVVARSQARAIRSHTAQVSLEgsskkvsKKSERKAAKTLGIVVGVFLLCWLPY 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56605936 267 FFTILLDPFLnfSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15055 240 YIVSLVDPYI--STPSSVFDVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
34-314 4.32e-130

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 372.73  E-value: 4.32e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLM 113
Cdd:cd15314   3 LYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFDIT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIegYDILVACSSSCPVMF 193
Cdd:cd15314  83 LCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLELNIKGI--YYNHVACEGGCLVFF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 194 NKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRK-DKKAAKTLGIVMGVFLLCWFPCFFTILL 272
Cdd:cd15314 161 SKVSSVVGSVFSFYIPAVIMLCIYLKIFLVAQRQARSIQSARTKSGASSSKmERKATKTLAIVMGVFLLCWTPFFLCNII 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56605936 273 DPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15314 241 DPFINYSIPPVLIEVLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
34-314 1.88e-110

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 323.24  E-value: 1.88e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLM 113
Cdd:cd15317   3 IYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMF 193
Cdd:cd15317  83 LCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTGANDEGLEEYSSEISCVGGCQLLF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 194 NKLWGTTLFVAgFFTPSSMMVGIYGKIFAVSKKHARVIDNLpENQNNQM---------RKDKKAAKTLGIVMGVFLLCWF 264
Cdd:cd15317 163 NKIWVLLDFLT-FFIPCLIMIGLYAKIFLVARRQARKIQNM-EDKFRSSeensskasaSRERKAAKTLAIVMGIFLFCWL 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 265 PCFFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15317 241 PYFIDTIVDEYSNFITPAIVFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
33-314 1.36e-96

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 287.53  E-value: 1.36e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15318   2 VIYLACAIGMLIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVM 192
Cdd:cd15318  82 LFCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLYTKAVEEGLAELLTSVPCVGSCQLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNKLWGTTLFVAgFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILL 272
Cdd:cd15318 162 YNKLWGWLNFPV-FFIPCLIMIGLYVKIFIVAKRQARAIASLLSDTNGASKRERKAAKTLGIAVGVYLLCWLPFTIDTMV 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56605936 273 DPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15318 241 DSLLNFITPPLLFDIIIWFAYFNSACNPLIYVFSYPWFRKAL 282
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
34-314 4.06e-84

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 256.32  E-value: 4.06e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLM 113
Cdd:cd15316   3 LYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMF 193
Cdd:cd15316  83 FCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFYTGVNDDGLEELVNALNCVGGCQIIL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 194 NKLWGTTLFVAgFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQ--------MRKDKKAAKTLGIVMGVFLLCWFP 265
Cdd:cd15316 163 NQNWVLVDFLL-FFIPTFAMIILYGKIFLVAKQQARKIEMTSSKAESSsesykdrvARRERKAAKTLGITVIAFLVSWLP 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56605936 266 CFFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15316 242 YLIDVLIDAFMNFITPPYIYEICCWCAYYNSAMNPLIYALFYPWFRKAI 290
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
34-314 9.84e-75

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 230.91  E-value: 9.84e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLM 113
Cdd:cd14967   2 LAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGydilvaCSSSCPVMF 193
Cdd:cd14967  82 CCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSV------VDCECEFTP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 194 NKLWGTTLFVAGFFTPSSMMVGIYGKIFAVskkharvidnlpenqnnqMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLD 273
Cdd:cd14967 156 NKIYVLVSSVISFFIPLLIMIVLYARIFRV------------------ARRELKAAKTLAIIVGAFLLCWLPFFIIYLVS 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56605936 274 PFL-NFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd14967 218 AFCpPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
36-313 2.96e-65

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 208.11  E-value: 2.96e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15056   5 TFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAIC-HPLHYctKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACS--SSCPVM 192
Cdd:cd15056  85 TASIMHLCCIALDRYYAICcQPLVY--KMTPLRVAVMLGGCWVIPTFISFLPIMQGWNHIGIEDLIAFNCASgsTSCVFM 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPE----------NQNNQMRKDKKAAKTLGIVMGVFLLC 262
Cdd:cd15056 163 VNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAHQIRSLQRagssnheadqHRNSRMRTETKAAKTLGIIMGCFCVC 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56605936 263 WFPCFFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15056 243 WAPFFVTNIVDPFIGYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRA 293
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
37-306 1.95e-61

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 197.51  E-value: 1.95e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd00637   4 LYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseaYADGIEGYDILVACSSSCPVMFNKL 196
Cdd:cd00637  84 ASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLL---GWGVYDYGGYCCCCLCWPDLTLSKA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPEN--QNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDP 274
Cdd:cd00637 161 YTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNssRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDV 240
                       250       260       270
                ....*....|....*....|....*....|....
gi 56605936 275 FL--NFSTPAVLFDALTWFGYFNSTCNPLIYGFF 306
Cdd:cd00637 241 FGpdPSPLPRILYFLALLLAYLNSAINPIIYAFF 274
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
37-313 8.29e-56

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 182.58  E-value: 8.29e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd15066   5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFST 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGiEGYDILVACSSSCPVMFNKL 196
Cdd:cd15066  85 ASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFLGWYTTE-EHLQYRKTHPDQCEFVVNKI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGTTLFVAGFFTPSSMMVGIYGKIFAVSKkharvidnlpenqnnqmrKDKKAAKTLGIVMGVFLLCWFPCFF----TILL 272
Cdd:cd15066 164 YALISSSVSFWIPCIVMIFTYYRIYLEAK------------------REHKAAKTLGIIMGAFILCWLPFFLwyvtTTLC 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 56605936 273 DPFLnfSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15066 226 GDAC--PYPPILVSILFWIGYFNSTLNPLIYAYFNRDFREA 264
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
42-313 4.89e-55

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 181.78  E-value: 4.89e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFH 121
Cdd:cd15065  10 IVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASILN 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAF---GVVFSEAYADGIEGYDILVACSSSCPVMFNKLWG 198
Cdd:cd15065  90 LCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFlpiHLGWHRLSQDEIKGLNHASNPKPSCALDLNPTYA 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 199 TTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDN---------------LPENQNNQMRKDKKAAKTLGIVMGVFLLCW 263
Cdd:cd15065 170 VVSSLISFYIPCLVMLLIYSRLYLYARKHVVNIKSqklpsesgskfqvpsLSSKHNNQGVSDHKAAVTLGIIMGVFLICW 249
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56605936 264 FPcFFTI-LLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15065 250 LP-FFIInIIAAFCKTCIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFRRA 299
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
36-314 5.76e-55

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 180.99  E-value: 5.76e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15051   5 VVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAF-GVVFSEAYADG-IEGYDIlvacSSSCPVMF 193
Cdd:cd15051  85 TASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFlPIHLGWNTPDGrVQNGDT----PNQCRFEL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 194 NKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVI------DNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCF 267
Cdd:cd15051 161 NPPYVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAKRInaltpaSTANSSKSAATAREHKATVTLAAVLGAFIICWFPYF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56605936 268 FTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15051 241 TYFTYRGLCGDNINETALSVVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
42-313 7.13e-54

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 178.78  E-value: 7.13e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTP-TNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGlTFCKIHYSFDLMLSITSIF 120
Cdd:cd15057  11 VLLTLLGNALVIAAVLRFRHLRSKvTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFG-SFCDVWVSFDIMCSTASIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 121 HLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAY-ADGIEGYDILVACSSSCPVMFNKLWGT 199
Cdd:cd15057  90 NLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQLGWHrADDTSEALALYADPCQCDSSLNRTYAI 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 200 TLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNL----PENQNNQ------MRKDKKAAKTLGIVMGVFLLCWFPCFFT 269
Cdd:cd15057 170 SSSLISFYIPVAIMIVTYTRIYRIARRQIRRIAALeraaQESTNPDsslrssLRRETKALKTLSIIMGVFVCCWLPFFIL 249
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 270 ILLDPFLNFST------PAVLFDALTWFGYFNSTCNPLIYGFFYPwFRRA 313
Cdd:cd15057 250 NCVLPFCDLRTaqfpcvPDTTFIVFVWLGWANSSLNPIIYAFNAD-FRKA 298
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
42-313 1.49e-52

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 174.05  E-value: 1.49e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFH 121
Cdd:cd15064  11 ILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCTASILH 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEgydilvacSSSCpvMFNKLWGTTL 201
Cdd:cd15064  91 LCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDSED--------PSEC--LISQDIGYTI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 202 F--VAGFFTPSSMMVGIYGKIFAVSKkharvidnlpenqnnqmrKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLNFS 279
Cdd:cd15064 161 FstFGAFYIPLLLMLILYWKIYRAAA------------------RERKAAKTLGIILGAFIVCWLPFFLVALIVPLCSHC 222
                       250       260       270
                ....*....|....*....|....*....|....*
gi 56605936 280 T-PAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15064 223 WiPLALKSFFLWLGYFNSLINPLIYTFFNKDFRKA 257
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
42-312 5.01e-52

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 172.84  E-value: 5.01e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFH 121
Cdd:cd15329  11 ILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVLLCTASILN 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW------SVPGAFAFGVVFSEAYADGIE---GYDIlvacssscpvm 192
Cdd:cd15329  91 LCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWllsaliSIPPLFGWKNKVNDPGVCQVSqdfGYQI----------- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 fnklWGTtlFVAgFFTPSSMMVGIYGKIFAVSKkharvidnlpenqnnqmrKDKKAAKTLGIVMGVFLLCWFPCFFTILL 272
Cdd:cd15329 160 ----YAT--FGA-FYIPLIVMLVLYYKIYRAAK------------------SERKAIKTLGIIMGAFTLCWLPFFILALL 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56605936 273 DPFL----NFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15329 215 RPFLkpikCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRT 258
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
43-313 9.84e-49

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 164.07  E-value: 9.84e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSV-ENCWYFGLTFCKIHYSFDLMLSITSIFH 121
Cdd:cd15067  11 LVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMtGGYWLFGRDWCDVWHSFDVLASTASILN 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAF-GVVFSEAYADGIEGYDILVACSSSCPVMFNKLwgtt 200
Cdd:cd15067  91 LCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFpAIAWWRAVDPGPSPPNQCLFTDDSGYLIFSSC---- 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 201 lfvAGFFTPSSMMVGIYGKIFAVSKkharvidnlpenqnnqmrKDKKAAKTLGIVMGVFLLCWFPCFFTILLD---PFLN 277
Cdd:cd15067 167 ---VSFYIPLVVMLFTYYRIYRAAA------------------KEQKAAKTLGIVMGVFILCWLPFFVTNILIgfcPSNC 225
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 56605936 278 FSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15067 226 VSNPDILFPLVTWLGYINSGMNPIIYACSSRDFRRA 261
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
36-313 1.82e-47

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 160.60  E-value: 1.82e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15061   4 SFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYadgiEGYDILVACSSScpvmFNK 195
Cdd:cd15061  84 TASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSW----HGRRGLGSCYYT----YDK 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 196 LWGTTLFVAGFFTPSSMMVGIYGKIFavskkhaRVIDnlpenqnnqmrKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPF 275
Cdd:cd15061 156 GYRIYSSMGSFFLPLLLMLFVYLRIF-------RVIA-----------KERKTAKTLAIVVGCFIVCWLPFFIMYLIEPF 217
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 56605936 276 LNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15061 218 CDCQFSEALSTAFTWLGYFNSVINPFIYAFYNKDFRRA 255
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
48-303 1.86e-46

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 158.23  E-value: 1.86e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936    48 GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENC-WYFGLTFCKIHYSFDLMLSITSIFHLCSVA 126
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGdWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936   127 VDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgAFAFGVVFSEAYADGIEGYDILVACSSSCP--VMFNKLWGTTLFVA 204
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVL--ALLLSLPPLLFGWTLTVPEGNVTVCFIDFPedLSKPVSYTLLISVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936   205 GFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQnnqmrKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLNFSTPA-- 282
Cdd:pfam00001 159 GFLLPLLVILVCYTLIIRTLRKSASKQKSSERTQ-----RRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSrl 233
                         250       260
                  ....*....|....*....|...
gi 56605936   283 --VLFDALTWFGYFNSTCNPLIY 303
Cdd:pfam00001 234 ldKALSVTLWLAYVNSCLNPIIY 256
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
37-313 2.50e-46

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 159.15  E-value: 2.50e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd15058   6 LLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKL 196
Cdd:cd15058  86 ASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPIMNQWWRANDPEANDCYQDPTCCDFRTNMA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDN-----LPENQNNQMR------------------KDKKAAKTLG 253
Cdd:cd15058 166 YAIASSVVSFYIPLLIMIFVYARVFLIATRQLQLIDKrrlrfQSECPAPQTTspegkrssgrrpsrltvvKEHKALKTLG 245
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 254 IVMGVFLLCWFPCFFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYgFFYPWFRRA 313
Cdd:cd15058 246 IIMGTFTLCWLPFFIANIINVFNRNLPPGEVFLLLNWLGYINSGLNPIIY-CRSPEFRTA 304
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
32-314 9.60e-45

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 154.04  E-value: 9.60e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15059   1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSeaYADGIEGYDILVACSsscpv 191
Cdd:cd15059  81 VLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFG--WKDEQPWHGAEPQCE----- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 mFNKLWGTTLF--VAGFFTPSSMMVGIYGKIFAVSKkharvidnlpenqnnqmRKDKKAAKTLGIVMGVFLLCWFPCFFT 269
Cdd:cd15059 154 -LSDDPGYVLFssIGSFYIPLLIMIIVYARIYRAAK-----------------RKERRFTLVLGVVMGAFVLCWLPFFFT 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 56605936 270 ILLDPFLNFS-TPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15059 216 YPLVVVCKTCgVPELLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
33-314 2.93e-44

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 152.41  E-value: 2.93e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15322   2 TLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDIlvacsssCPVM 192
Cdd:cd15322  82 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGPI-------CKIN 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKharvidnlpenqnnqmrKDKKAAKTLGIVMGVFLLCWFPCFFTILL 272
Cdd:cd15322 155 DEKWYIISSCIGSFFAPCLIMVLVYIRIYQIAKN-----------------REKRFTFVLAVVIGVFVICWFPFFFTYTL 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56605936 273 DPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15322 218 TAVCDCSVPETLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
35-313 8.85e-44

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 151.34  E-value: 8.85e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  35 YSLMACA-IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENC-WYFGLTFCKIHYSFDL 112
Cdd:cd15053   3 WALFLLLlPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGkWYLGPILCDIYIAMDV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDilvaCssscpVM 192
Cdd:cd15053  83 MCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEE----C-----RF 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVskkharvidnlpenqnnqMRKDKKAAKTLGIVMGVFLLCWFPCFFTILL 272
Cdd:cd15053 154 YNPDFIIYSSISSFYIPCIVMLLLYYRIFRA------------------LRREKKATKTLAIVLGVFLFCWLPFFTLNIL 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56605936 273 DPF------LNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15053 216 NAIcpklqnQSCHVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKA 262
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
32-314 3.64e-43

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 150.83  E-value: 3.64e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15959   1 WLAGALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEgyDILVACSSS--- 188
Cdd:cd15959  81 VLCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMNQWWRDGAD--EEAQRCYDNprc 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 189 CPVMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVI---------DNLPENQNNQMR----------KDKKAA 249
Cdd:cd15959 159 CDFVTNMPYAIVSSTVSFYVPLLVMIFVYVRVFVVATRQVRLIrkdkvrfppEESPPAESRPACgrrpsrllaiKEHKAL 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56605936 250 KTLGIVMGVFLLCWFPCFFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYgFFYPWFRRAL 314
Cdd:cd15959 239 KTLGIIMGTFTLCWLPFFVANIIKVFCRSLVPDPAFLFLNWLGYANSAFNPIIY-CRSPDFRSAF 302
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
42-314 1.28e-42

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 148.50  E-value: 1.28e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFH 121
Cdd:cd15326  11 ILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDilvacsssCPVMFNKLWGTTL 201
Cdd:cd15326  91 LCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWKEPAPPDDKV--------CEITEEPFYALFS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 202 FVAGFFTPSSMMVGIYGKIFAVSKKHARvidnlpenqnnqmrkDKKAAKTLGIVMGVFLLCWFPCFFTILLDP-FLNFST 280
Cdd:cd15326 163 SLGSFYIPLIVILVMYCRVYIVALKFSR---------------EKKAAKTLGIVVGMFILCWLPFFIALPLGSlFSHLKP 227
                       250       260       270
                ....*....|....*....|....*....|....
gi 56605936 281 PAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15326 228 PETLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
36-313 1.54e-40

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 142.88  E-value: 1.54e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15331   5 IILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMDVLCC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHpLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACssscpvMFNK 195
Cdd:cd15331  85 TASILHLVAIALDRYWAVTN-IDYIRRRTAKRILIMIAVVWFVSLIISIAPLFGWKDEDDLDRVLKTGVC------LISQ 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 196 LWGTTLF--VAGFFTPSSMMVGIYGKIFAVSKkharvidnlpenqnnqmrKDKKAAKTLGIVMGVFLLCWFPCFFTILLD 273
Cdd:cd15331 158 DYGYTIFstVGAFYVPLLLMIIIYWKIYQAAK------------------RERKAARTLAIITGAFVVCWLPFFLVALVM 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 56605936 274 PF-LNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15331 220 PFcGAWQISRFLESFFLWLGYFNSLLNPIIYTIFSPDFRGA 260
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
36-313 2.67e-40

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 142.25  E-value: 2.67e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15063   5 LVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAF-GVVFSEAYADGIEGYDILVACSSSCPVMFN 194
Cdd:cd15063  85 TASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFpPLVGWNDGKDGIMDYSGSSSLPCTCELTNG 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 195 KLWGTTLFVAGFFTPSSMMVGIYGKIFAVSkkharvidnlpenqnnqmRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDP 274
Cdd:cd15063 165 RGYVIYSALGSFYIPMLVMLFFYFRIYRAA------------------RMETKAAKTVAIIVGCFIFCWLPFFTVYLVRA 226
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 56605936 275 FLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15063 227 FCEDCIPPLLFSVFFWLGYCNSALNPCIYALFSRDFRFA 265
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
33-303 3.53e-40

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 143.08  E-value: 3.53e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15957   2 GMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAY-ADGIEGYDILvACSSSCPV 191
Cdd:cd15957  82 LCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYrATHQEAINCY-AEETCCDF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMR-------------------KDKKAAKTL 252
Cdd:cd15957 161 FTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHNQNIdqngsgggggnrrrskfclKEHKALKTL 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56605936 253 GIVMGVFLLCWFPCFFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIY 303
Cdd:cd15957 241 GIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIY 291
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
37-314 8.91e-40

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 140.88  E-value: 8.91e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd15330   6 FLGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW------SVPGAFAFGVVFSEAYADgiegydilvACSSScp 190
Cdd:cd15330  86 SSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWligfsiSIPPMLGWRTPEDRSDPD---------ACTIS-- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 vmfnKLWGTTLF--VAGFFTPSSMMVGIYGKIFAVSKkharvidnlpenqnnqmrKDKKAAKTLGIVMGVFLLCWFPCFF 268
Cdd:cd15330 155 ----KDPGYTIYstFGAFYIPLILMLVLYGRIFKAAA------------------RERKTVKTLGIIMGTFILCWLPFFI 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56605936 269 TILLDPFLNFS--TPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15330 213 VALVLPFCESTchMPELLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
37-313 9.17e-40

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 140.64  E-value: 9.17e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd15060   6 LLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW------SVPGAFafgvvfseAYADGIEGYDIlvacSSSCP 190
Cdd:cd15060  86 ASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWalsaliSVPPLI--------GWNDWPENFTE----TTPCT 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 VMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKkharvidnlpenqnnqmrKDKKAAKTLGIVMGVFLLCWFPCFFTI 270
Cdd:cd15060 154 LTEEKGYVIYSSSGSFFIPLLIMTIVYVKIFIATS------------------KERRAARTLGIIMGVFVVCWLPFFLMY 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56605936 271 LLDPFLNFSTPAVLF-DALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15060 216 VILPFCETCSPSAKVvNFITWLGYVNSALNPVIYTIFNLDFRRA 259
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
38-313 9.84e-40

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 140.70  E-value: 9.84e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  38 MACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSIT 117
Cdd:cd15062   7 LGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 118 SIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAyadgiegyDILVACSSSCPVMFNKLW 197
Cdd:cd15062  87 SIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWK--------EPAPADEQACGVNEEPGY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 198 GTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARvidnlpenqnnqmrkDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFL- 276
Cdd:cd15062 159 VLFSSLGSFYLPLAIILVMYCRVYVVAFKFSR---------------EKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLFs 223
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 56605936 277 NFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15062 224 TLKPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFKRA 260
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
36-305 1.02e-39

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 142.40  E-value: 1.02e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTP-TNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGlTFCKIHYSFDLML 114
Cdd:cd15319   5 CLLSLLILWTLLGNILVCAAVVRFRHLRSKvTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYAD------GIEGYDILVACSSS 188
Cdd:cd15319  84 STASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVQLNWHKDsgddwvGLHNSSISRQVEEN 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 189 CPVMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNN-------------------QMRKDKKAA 249
Cdd:cd15319 164 CDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQIRRISSLERAAEHaqscrsnridchhhtslrtSIKKETKVL 243
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56605936 250 KTLGIVMGVFLLCWFPCFFTILLDPFLNFST-------PAV---LFDALTWFGYFNSTCNPLIYGF 305
Cdd:cd15319 244 KTLSVIMGVFVCCWLPFFILNCMVPFCDRPPadpdaglPCVsetTFDVFVWFGWANSSLNPIIYAF 309
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
28-313 2.19e-39

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 139.93  E-value: 2.19e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  28 LGVRAAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIH 107
Cdd:cd15333   1 LGLKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIW 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 108 YSFDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWsvpgAFAFGVVFSEAYADGIEGYDILVACSS 187
Cdd:cd15333  81 LSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVW----VISISISLPPFFWRQAKAEEEVSECVV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 188 SCPVMFNKLWGTtlfVAGFFTPSSMMVGIYGKIFAVSKKharvidnlpenqnnqmrKDKKAAKTLGIVMGVFLLCWFPCF 267
Cdd:cd15333 157 NTDHILYTVYST---VGAFYIPTLLLIALYGRIYVEARA-----------------RERKATKTLGIILGAFIVCWLPFF 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56605936 268 FTILLDPFLNFSTP--AVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15333 217 IISLVLPICKDACWfhLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQA 264
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
27-314 6.63e-39

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 138.90  E-value: 6.63e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  27 SLGVRAAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKI 106
Cdd:cd15321   2 SVQATAAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 107 HYSFDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGydilvaCS 186
Cdd:cd15321  82 YLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQG------GL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 187 SSCPVMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKharvidnlpenqnnqmrKDKKAAKTLGIVMGVFLLCWFPC 266
Cdd:cd15321 156 PQCKLNEEAWYILSSSIGSFFAPCLIMILVYLRIYLIAKN-----------------REKRFTFVLAVVIGVFVLCWFPF 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 267 FFTILLDPFLNFS--TPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15321 219 FFSYSLGAICPELckVPHSLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
30-314 8.40e-39

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 139.27  E-value: 8.40e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  30 VRAAMYSLMacaIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIhYS 109
Cdd:cd14993   2 VLIVLYVVV---FLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKA-VP 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 110 FDLMLSI-TSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFA--FGVVFSEAYADGIEGYDILVA-C 185
Cdd:cd14993  78 YLQGVSVsASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMlpLLVVYELEEIISSEPGTITIYiC 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 186 SSSCPV-MFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNN---QMRKDKKAAKTLGIVMGVFLL 261
Cdd:cd14993 158 TEDWPSpELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSsrrILRSKKKVARMLIVVVVLFAL 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56605936 262 CWFPCFFTILLDPFLNFSTP------AVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd14993 238 SWLPYYVLSILLDFGPLSSEesdenfLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
37-314 8.49e-39

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 140.14  E-value: 8.49e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTP-TNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGlTFCKIHYSFDLMLS 115
Cdd:cd15320   7 FLSVLILSTLLGNTLVCAAVIRFRHLRSKvTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAF-GVVFSEAYADGIEGYDILVA----CSSSCP 190
Cdd:cd15320  86 TASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFiPVQLNWHKAKPTSFLDLNASlrdlTMDNCD 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 VMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKK-------------HARVIDNLPENQNN------------QMRKD 245
Cdd:cd15320 166 SSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKqirrisaleraavHAKNCQNSTGNRGSgdcqqpessfkmSFKRE 245
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56605936 246 KKAAKTLGIVMGVFLLCWFPCFFTILLDPFLN------FSTPAVLFDALTWFGYFNSTCNPLIYGFFYPwFRRAL 314
Cdd:cd15320 246 TKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKptstepFCISSTTFDVFVWFGWANSSLNPIIYAFNAD-FRKAF 319
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
32-314 3.34e-38

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 136.99  E-value: 3.34e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15323   1 AGLAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSeAYADGIEgydilvACSSSCPV 191
Cdd:cd15323  81 VLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLIS-MYRDPEG------DVYPQCKL 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKharvidnlpenqnnqmrKDKKAAKTLGIVMGVFLLCWFPCFFTIL 271
Cdd:cd15323 154 NDETWYILSSCIGSFFAPCLIMILVYIRIYRVAKA-----------------REKRFTFVLAVVMGVFVVCWFPFFFSYS 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56605936 272 LDPFLN--FSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15323 217 LYGICReaCEVPEPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
32-314 5.89e-38

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 137.34  E-value: 5.89e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15958   1 AGMSLLMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPV 191
Cdd:cd15958  81 VLCVTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFLPIMMHWWRDEDDQALKCYEDPGCCDF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMR----------------KDKKAAKTLGIV 255
Cdd:cd15958 161 VTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKKQIKKIDKCEGRFHNTLTglgrkckrrpsrilalREQKALKTLGII 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56605936 256 MGVFLLCWFPCFFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYgFFYPWFRRAL 314
Cdd:cd15958 241 MGVFTLCWLPFFLVNVVNVFNRELVPDWLFVFFNWLGYANSAFNPIIY-CRSPDFRKAF 298
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
37-314 1.57e-37

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 135.04  E-value: 1.57e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd15327   6 FLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEgydilvacSSSCPVMFNKL 196
Cdd:cd15327  86 ASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPPPPD--------ESICSITEEPG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARvidnlpenqnnqmrkDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFL 276
Cdd:cd15327 158 YALFSSLFSFYLPLMVILVMYFRVYVVALKFSR---------------EKKAAKTLAIVVGVFILCWFPFFFVLPLGSFF 222
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 56605936 277 NFSTPA-VLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15327 223 PALKPSeMVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
37-314 9.40e-36

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 130.43  E-value: 9.40e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd15335   6 TLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADgiegydilVACSSSCPVMFNKL 196
Cdd:cd15335  86 CSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFWRNHHD--------ANIPSQCIIQHDHV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGTTLFVAG-FFTPSSMMVGIYGKIFAVSKkharvidnlpenqnnqmrKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPF 275
Cdd:cd15335 158 IYTIYSTFGaFYIPLTLILILYYRIYHAAS------------------RERKAARILGLILGAFILSWLPFFIKELIVGL 219
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 56605936 276 LNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15335 220 SVMTVSPEVADFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
42-314 2.16e-35

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 129.24  E-value: 2.16e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFH 121
Cdd:cd15325  11 ILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYAdgiegydilvACSSSCPVMFNKLWGTTL 201
Cdd:cd15325  91 LCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWKEP----------APEDETICQITEEPGYAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 202 FVA--GFFTPSSMMVGIYGKIFAVSKKHARvidnlpenqnnqmrkDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFL-NF 278
Cdd:cd15325 161 FSAlgSFYLPLAIILVMYCRVYVVALKFSR---------------EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFpAY 225
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 56605936 279 STPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15325 226 KPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
42-314 2.32e-35

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 129.22  E-value: 2.32e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFH 121
Cdd:cd15324  11 ILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSIVH 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYAD-----GIEGYDILVACSSScpvmfnkl 196
Cdd:cd15324  91 LCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKHDEwecllNDETWYILSSCTVS-------- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 wgttlfvagFFTPSSMMVGIYGKIFAVSKkharvidnlpenqnnqMRkDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFL 276
Cdd:cd15324 163 ---------FFAPGLIMILVYCKIYRVAK----------------MR-EKRFTFVLAVVMGVFVLCWFPFFFTYSLHAVC 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 56605936 277 --NFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15324 217 rkRCGIPDALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
32-313 5.26e-35

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 129.35  E-value: 5.26e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15048   1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWsvpgAFAFGVvfseaYADGIEGYDILVACSS---- 187
Cdd:cd15048  81 YTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVW----ILAFLL-----YGPAIIGWDLWTGYSIvptg 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 188 SCPVMFNKLWGTTLFVA--GFFTPSSMM----VGIYGKIFAVSK-KHARVIDNLPENQNNQ----------MRKDKKAAK 250
Cdd:cd15048 152 DCEVEFFDHFYFTFITSvlEFFIPFISVsffnLLIYLNIRKRSRrRPLRSVPILPASQNPSrarsqreqvkLRRDRKAAK 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56605936 251 TLGIVMGVFLLCWFPCFFTILLDPFLNFS-TPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15048 232 SLAILVLVFLICWAPYTILTIIRSFCSGScVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKA 295
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
33-314 5.89e-35

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 128.38  E-value: 5.89e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15054   2 WVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVAC---SSSC 189
Cdd:cd15054  82 MCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWHELGHERTLPNLTSgtvEGQC 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 190 PVMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHArvidnlpenqnnqmrkdkKAAKTLGIVMGVFLLCWFPCFFT 269
Cdd:cd15054 162 RLLVSLPYALVASCLTFFLPSGAICFTYCRILLAARKAL------------------KASLTLGILLGMFFVTWLPFFVA 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56605936 270 ILLDPFLNfSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15054 224 NVVQAVCD-CVSPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
33-314 1.60e-34

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 127.01  E-value: 1.60e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITI-FGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVEN-CWYFGLTFCKIHYSF 110
Cdd:cd15310   1 AYYALSYCALILAIvFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGgVWNFSRICCDVFVTL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 111 DLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRR---LLLVCWSVPGAFAFGVVFseayadGIEGYDILVACSS 187
Cdd:cd15310  81 DVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRvslMITAVWVLAFAVSCPLLF------GFNTTGDPTVCSI 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 188 SCPVMFnkLWGTtlfVAGFFTPSSMMVGIYGKIFAVskkharvidnlpenqnnqMRKDKKAAKTLGIVMGVFLLCWFPCF 267
Cdd:cd15310 155 SNPDFV--IYSS---VVSFYLPFGVTLLVYVRIYVV------------------LLREKKATQMLAIVLGAFIVCWLPFF 211
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56605936 268 FTILLDPFLNF-STPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15310 212 LTHILNTHCQAcHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
44-313 5.92e-34

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 125.62  E-value: 5.92e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15050  13 ITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLF 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGydilVACSSSCPVMFNKLWGTTLFV 203
Cdd:cd15050  93 ILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILGWHHFARGGER----VVLEDKCETDFHDVTWFKVLT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 204 A--GFFTPSSMMVGIYGKIFavskkharvidnlpenqnNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLNFSTP 281
Cdd:cd15050 169 AilNFYIPSLLMLWFYAKIF------------------KAVNRERKAAKQLGFIMAAFILCWIPYFILFMVIAFCKNCCN 230
                       250       260       270
                ....*....|....*....|....*....|..
gi 56605936 282 AVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15050 231 ENLHMFTIWLGYINSTLNPFIYPLCNENFKKT 262
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
42-314 8.32e-34

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 125.81  E-value: 8.32e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFI-TIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIF 120
Cdd:cd15207  10 IFLlCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQGVSVAASVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 121 HLCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCW------SVPGAFAFGVVFSEAYadgieGYDILVACSSSCP-VMF 193
Cdd:cd15207  90 TLVAIAVDRYRAVVHPTE--PKLTNRQAFVIIVAIWvlalaiMIPQALVLEVKEYQFF-----RGQTVHICVEFWPsDEY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 194 NKLWGTTLFVAGFFTPSSMMVGIYGKIFA--VSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTIL 271
Cdd:cd15207 163 RKAYTTSLFVLCYVAPLLIIAVLYVRIGYrlWFKPVPGGGSASREAQAAVSKKKVRVIKMLIVVVVLFALSWLPLHTVTM 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56605936 272 LDPFLNFSTP------AVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15207 243 LDDFGNLSPNqrevlyVYIYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
37-313 8.39e-34

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 125.12  E-value: 8.39e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSV-ENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15052   6 LLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELfGGVWPLPLVLCLLWVTLDVLFC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAfgvvfSEAYADGIEGYDILVAcSSSCpVMFN- 194
Cdd:cd15052  86 TASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGIS-----SPIPVLGIIDTTNVLN-NGTC-VLFNp 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 195 --KLWGTtlfVAGFFTPSSMMVGIYGKIFAVskkharvidnlpenqnnqMRKDKKAAKTLGIVMGVFLLCWFPCFFTILL 272
Cdd:cd15052 159 nfVIYGS---IVAFFIPLLIMVVTYALTIRL------------------LSNEQKASKVLGIVFAVFVICWCPFFITNIL 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56605936 273 DPF---LNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15052 218 TGLceeCNCRISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRRA 261
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
39-314 1.77e-32

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 121.66  E-value: 1.77e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  39 ACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITS 118
Cdd:cd15049   8 GSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 119 IFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYadgIEGYDILVACSSSCPVMFNKLWG 198
Cdd:cd15049  88 VMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGWQY---FVGERTVPDGQCYIQFLDDPAIT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 199 TTLFVAGFFTPSSMMVGIYGKIFAVSkkharvidnlpenqnnqmRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLNF 278
Cdd:cd15049 165 FGTAIAAFYLPVLVMTILYWRIYRET------------------ARERKAARTLSAILLAFIITWTPYNILVLVSTFCAK 226
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 56605936 279 STPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15049 227 CIPDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
37-314 5.17e-32

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 120.14  E-value: 5.17e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd15309   6 LLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICHPLHYCTKMTipvVRRLLLVCWSVPGAFAFGVVFSEAYAdgiegydiLVACSSSCPVMFNKL 196
Cdd:cd15309  86 ASILNLCAISIDRYTAVAMPMLYNTRYS---SKRRVTVMISVVWVLSFAISCPLLFG--------LNNTDQNECIIANPA 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGTTLFVAGFFTPSSMMVGIYGKIFAVskkharvidnlpenqnnqMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFL 276
Cdd:cd15309 155 FVVYSSIVSFYVPFIVTLLVYVQIYIV------------------LQKEKKATQMLAIVLGVFIICWLPFFITHILNMHC 216
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 56605936 277 NFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15309 217 DCNIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
43-315 1.49e-30

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 116.59  E-value: 1.49e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15334  12 LMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEgydilvacsSSCPVMFNKLWGTTLF 202
Cdd:cd15334  92 SAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSRE---------DECIIKHDHIVFTIYS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 203 VAG-FFTPSSMMVGIYGKIFAVSKkharvidnlpenqnnqmrKDKKAAKTLGIVMGVFLLCWFPCFFT-ILLDPFLNFST 280
Cdd:cd15334 163 TFGaFYIPLALILILYYKIYRAAT------------------RERKAATTLGLILGAFVICWLPFFVKeVIVNTCDSCYI 224
                       250       260       270
                ....*....|....*....|....*....|....*
gi 56605936 281 PAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRALK 315
Cdd:cd15334 225 SEEMSNFLTWLGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
37-314 3.11e-30

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 116.15  E-value: 3.11e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd14969   6 YLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICHPLHYcTKMTIPVVRRLLLVCWsvpgafAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKL 196
Cdd:cd14969  86 VSISTLAALAFERYLVIVRPLKA-FRLSKRRALILIAFIW------LYGLFWALPPLFGWSSYVPEGGGTSCSVDWYSKD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGT-----TLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQM--RKDKKAAKTLGIVMGVFLLCWFP---- 265
Cdd:cd14969 159 PNSlsyivSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRtkKAEKKVAKMVLVMIVAFLIAWTPyavv 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56605936 266 CFFTILLDPFL---NFSTPAVLFdALTwfgyfnSTC-NPLIYGFFYPWFRRAL 314
Cdd:cd14969 239 SLYVSFGGESTippLLATIPALF-AKS------STIyNPIIYVFMNKQFRRAL 284
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
33-314 4.69e-30

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 115.82  E-value: 4.69e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFI-TIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFglTFCKIHYSFD 111
Cdd:cd14968   1 AVYIVLEVLIAVlSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLPTNF--HGCLFMACLV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgAFAFGVVFSEAYADGIEGYDILVACSSSCP- 190
Cdd:cd14968  79 LVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVL--SFLVGLTPMFGWNNGAPLESGCGEGGIQCLf 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 ---------VMFNklwgttlFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQ--MRKDKKAAKTLGIVMGVF 259
Cdd:cd14968 157 eevipmdymVYFN-------FFACVLVPLLIMLVIYLRIFRVIRKQLRQIESLLRSRRSRstLQKEVKAAKSLAIILFLF 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56605936 260 LLCWFPCFFTILLDPFL-NFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd14968 230 ALCWLPLHIINCITLFCpECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
36-306 1.37e-29

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 113.89  E-value: 1.37e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENC-WYFGLTFCKIHYSFDLML 114
Cdd:cd15328   5 TLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRrWQLGRSLCQVWISFDVLC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVV---FSEAYADGIEgydilvacssSCPV 191
Cdd:cd15328  85 CTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLlfgWGETYSEDSE----------ECQV 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKharvidnlpenqnnqmrkDKKAAKTLGIVMGVFLLCWFPCFFTIL 271
Cdd:cd15328 155 SQEPSYTVFSTFGAFYLPLCVVLFVYWKIYKAAQK------------------EKRAALMVGILIGVFVLCWIPFFLTEL 216
                       250       260       270
                ....*....|....*....|....*....|....*
gi 56605936 272 LDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFF 306
Cdd:cd15328 217 ISPLCSCDIPPIWKSIFLWLGYSNSFFNPLIYTAF 251
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
33-314 2.02e-29

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 114.24  E-value: 2.02e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKI-HYSF 110
Cdd:cd15203   1 IILILLYGLIIVLgVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLvPSLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 111 DLMLSItSIFHLCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCW------SVPGAFAFGVVFSEAYADGIEGYdilvA 184
Cdd:cd15203  81 GVSIFV-STLTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWilslllSLPLAIFQELSDVPIEILPYCGY----F 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 185 CSSSCPVMFNKL-WGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPEN---QNNQMRKDKKAAKTLGIVM-GVF 259
Cdd:cd15203 154 CTESWPSSSSRLiYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLssrRRRSELRRKRRTNRLLIAMvVVF 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56605936 260 LLCWFP--CF-FTILLDPFLNFSTPAV-LFDALT-WFGyFNSTC-NPLIYGFFYPWFRRAL 314
Cdd:cd15203 234 AVCWLPlnLFnLLRDFEPLPQIDGRHFyLIFLIChLIA-MSSACvNPLLYGWLNDNFRKEF 293
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
42-319 2.34e-29

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 113.89  E-value: 2.34e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFH 121
Cdd:cd15307  11 VLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIMH 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHYC-TKMTIPVVRRLLLV-CWSVPGAFAFGVVFSEAYAdgiegyDILVACSSSCPVMFNKLWGT 199
Cdd:cd15307  91 LCTISVDRYLSLRYPMRFGrNKTRRRVTLKIVFVwLLSIAMSLPLSLMYSKDHA------SVLVNGTCQIPDPVYKLVGS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 200 tlfVAGFFTPSSMMVGIYGKIfavskkhARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLNFS 279
Cdd:cd15307 165 ---IVCFYIPLGVMLLTYCLT-------VRLLARQRSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAEC 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 56605936 280 TPAV---LFDALTWFGYFNSTCNPLIYGFFYPWFRRALKYILL 319
Cdd:cd15307 235 EERIshwVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLL 277
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
37-314 6.09e-29

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 112.33  E-value: 6.09e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENC-WYFGLTFCKIHYSFDLMLS 115
Cdd:cd15304   6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYrWPLPSKLCAVWIYLDVLFS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGV-VFseayadGIEGyDILVACSSSCPVMFN 194
Cdd:cd15304  86 TASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIpVF------GLQD-DSKVFKEGSCLLADE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 195 KLWGTTLFVAgFFTPSSMMVGIYgkiFAVSKKHARVIDNlpenqnnqmrkDKKAAKTLGIVMGVFLLCWFPCFFT----I 270
Cdd:cd15304 159 NFVLIGSFVA-FFIPLTIMVITY---FLTIKSLQQSISN-----------EQKASKVLGIVFFLFVVMWCPFFITnvmaV 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56605936 271 LLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15304 224 ICKESCNEVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
32-317 4.92e-27

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 107.61  E-value: 4.92e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMAcaIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSV-ENCWYFGLTFCKIHYSF 110
Cdd:cd15306   3 AALLILMV--IIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILfEAMWPLPLVLCPIWLFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 111 DLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSeayadGIEGYDILVAcSSSCP 190
Cdd:cd15306  81 DVLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVPIK-----GIETDVDNPN-NITCV 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 VMFNKLWGTTLF--VAGFFTPSSMMVGIYGKIFAVSKKHArvidnlpenqnnqMRKDKKAAKTLGIVMGVFLLCWFPCFF 268
Cdd:cd15306 155 LTKERFGDFILFgsLAAFFTPLAIMIVTYFLTIHALRKQT-------------ITNEQRASKVLGIVFFLFLLMWCPFFI 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 56605936 269 T----ILLDPfLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL-KYI 317
Cdd:cd15306 222 TnitsVLCDS-CNQTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFgRYI 274
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
42-314 1.25e-26

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 106.65  E-value: 1.25e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHySFDLMLSI-TSIF 120
Cdd:cd15389  11 IVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLS-RFAQYCSVyVSTL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 121 HLCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCWSVPGAFAFG-VVFSEAYADGIEGYDILVACSSSCP---VMFNKL 196
Cdd:cd15389  90 TLTAIALDRHRVILHPLK--PRITPCQGVVVIAIIWIMASCLSLPhAIYQKLVEFEYSNERTRSRCLPSFPepsDLFWKY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFL 276
Cdd:cd15389 168 LDLATFILQYVLPLLIIGVAYTRVAKKLWLRNAIGDVTTEQYVAQRRKKKKTIKMLMLVVLLFAICWLPLNCYHVLLSSH 247
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 56605936 277 NFSTPAVLFDALTWFGyFNSTC-NPLIYGFFYPWFRRAL 314
Cdd:cd15389 248 PIRSNSALFFAFHWLA-MSSTCyNPFIYCWLNDSFRSEL 285
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
37-314 2.70e-26

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 105.37  E-value: 2.70e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSV-ENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15305   6 LILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILyDYAWPLPRYLCPIWISLDVLFS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSeayadGIEGyDILVACSSSCPVMFNK 195
Cdd:cd15305  86 TASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPIPVI-----GLQD-DEKVFVNGTCVLNDEN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 196 LWGTTLFVAgFFTPSSMMVGIYGKIFAVSKKHARVidnlpenqNNQmrkdKKAAKTLGIVMGVFLLCWFPCFFT----IL 271
Cdd:cd15305 160 FVLIGSFVA-FFIPLIIMVITYCLTIQVLQRQQAI--------NNE----RRASKVLGIVFFLFLIMWCPFFITnilsVL 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 56605936 272 LDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15305 227 CKEACDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAF 269
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
28-312 4.36e-26

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 104.90  E-value: 4.36e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  28 LGVRAAMYSLmacaifITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIH 107
Cdd:cd15301   3 IVIVAAVLSL------VTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 108 YSFDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYadgIEGYdiLVACSS 187
Cdd:cd15301  77 LAIDYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPWIYSWPY---IEGK--RTVPAG 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 188 SCPVMF---NKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHarvidnlpenqnnQMRKDKKAAKTLGIVMGVFLLCWF 264
Cdd:cd15301 152 TCYIQFletNPYVTFGTALAAFYVPVTIMCILYWRIWRETKKR-------------QKKQESKAAKTLSAILLAFIVTWT 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 265 PCFFTILLDPFLNFS--TPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15301 219 PYNVLVLIKAFFPCSdtIPTELWDFSYYLCYINSTINPLCYALCNAAFRR 268
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
41-313 6.15e-26

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 105.16  E-value: 6.15e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  41 AIFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSI 119
Cdd:cd15208   9 LVFIVgLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSVSVSV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 120 FHLCSVAVDRFYAICHPLHYctKMTIPVVRRLLLVCWSVpgafAFGVVFSEAYADGIEG-------YDILVACSSSCPV- 191
Cdd:cd15208  89 LTLSCIALDRWYAICHPLMF--KSTAKRARVSILIIWIV----SLLIMIPQAIVMECSRvvplankTILLTVCDERWSDs 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLWGTTLFVAGFFTPSSMMVGIYGKIF-------------AVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGV 258
Cdd:cd15208 163 IYQKVYHICFFLVTYLLPLCLMILAYFQIFrklwcrqipgtssVVQRKWNKPRKSAVAAEEKQLRSRRKTAKMLIVVVIM 242
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 259 FLLCWFPC-FFTILLDPFLNF----STPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15208 243 FAICYLPVhLLNILRYVFGLFtvdrETIYAWFLFSHWLVYANSAINPIIYNFMSGKFREE 302
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
42-311 6.18e-25

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 101.45  E-value: 6.18e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMP-YSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIF 120
Cdd:cd15308  11 ILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPlYVYSEFQGGVWTLSPVLCDALMTMDVMLCTASIF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 121 HLCSVAVDRFYAICHPLHYCTKMTipVVRRLLLV--CWSVPGAFAFGVVFSEAYADG-------IEGYDILVACSsscpv 191
Cdd:cd15308  91 NLCAISVDRFIAVSVPLNYNRRQG--SVRQLLLIsaTWILSFAVASPVIFGLNNVPNrdpavckLEDNNYVVYSS----- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 mfnklwgttlfVAGFFTPSSMMVGIYGKIFavskkharvidnlpenqnNQMRKDKKAAKTLGIVMGVFLLCWFPcFFTIL 271
Cdd:cd15308 164 -----------VCSFFIPCPVMLVLYCAMF------------------RGLGRERKAMRVLPVVVGAFLFCWTP-FFVVH 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56605936 272 LDPFL--NFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFR 311
Cdd:cd15308 214 ITRALceSCSIPPQLISIVTWLGYVNSALNPVIYTVFNAEFR 255
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
33-314 1.80e-24

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 100.53  E-value: 1.80e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITIFGNLAMIISISYFKQL-HTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15104   1 AAGVILAVLSPLIITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgafAFGVVFSEAYADGIEGYDILVACSSSCPV 191
Cdd:cd15104  81 ITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLY----SGLIGFLPLISPQFQQTSYKGKCSFFAAF 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLWgtTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMR-----KDKKAAKTLGIVMGVFLLCWFPC 266
Cdd:cd15104 157 HPRVLL--VLSCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALARQIHprrtlSDFKAARTVAVLIGCFLLSWLPF 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56605936 267 FFTILLDPFLNFSTPA-VLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15104 235 QITGLVQALCDECKLYdVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
33-312 3.82e-24

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 99.68  E-value: 3.82e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSlMACAIfiTIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLgFTIMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd14970   5 AVYS-VVCVV--GLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELF-LLGLPFLATSYLLGYWPFGEVMCKIVLSVDA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYcTKMTIPVVRRLLLVC-WSVPGAFAFGVVFseaYADGIEGYDILVACSSSCPv 191
Cdd:cd14970  81 YNMFTSIFCLTVMSVDRYLAVVHPVKS-LRFRTPRKAKLVSLCvWALSLVLGLPVII---FARTLQEEGGTISCNLQWP- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLWGTTL----FVAGFFTPSSMMVGIYGKIFavskKHARVIDNLPENQNNQMRKD-KKAAKTLGIVMGVFLLCWFPC 266
Cdd:cd14970 156 DPPDYWGRVFtiytFVLGFAVPLLVITVCYSLII----RRLRSSRNLSTSGAREKRRArRKVTRLVLVVVAVFVVCWLPF 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56605936 267 F------FTILLDPFLNFSTPAVLFDALtwfGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd14970 232 HvfqivrLLIDPPETLTVVGVFLFCIAL---SYANSCLNPILYAFLDENFRK 280
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
43-314 5.96e-24

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 99.58  E-value: 5.96e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15980  12 LLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISVSASVFTL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 123 CSVAVDRFYAICHPlhYCTKMTIPVVRRLLLVCWSV------PGAFAFGVVFSEAYADGIEGYD---ILVACSSSCPVM- 192
Cdd:cd15980  92 VAIAVDRFRCIVYP--FKQKLTISTAVVIIVIIWVLaiaimcPSAVMLHVQEEKNYRVVLGSQNktsPVYWCREDWPNQe 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQM--RKDKKAAKTLGIVMGVFLLCWFPCFFTI 270
Cdd:cd15980 170 MRKIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAMPHTGKHNQEQRHVvsRKKQKVIKMLLIVALLFILSWLPLWTLM 249
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 271 LLDPFLNFSTPAV------LFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15980 250 MLSDYANLSPNQLqiiniyIYPFAHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
32-311 8.79e-24

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 98.91  E-value: 8.79e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMacaIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHySFD 111
Cdd:cd15390   4 SIVFVVM---VLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFS-NFV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSIT-SIFHLCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCWSVPGAFAF-GVVFSEAYADGIEGYDILVACSSSC 189
Cdd:cd15390  80 AITTVAaSVFTLMAISIDRYIAIVHPLR--PRLSRRTTKIAIAVIWLASFLLALpQLLYSTTETYYYYTGSERTVCFIAW 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 190 PV----MFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPeNQNNQMRKDKKAAKTLGIVMGVFLLCWFP 265
Cdd:cd15390 158 PDgpnsLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGENTP-RQLESVRAKRKVVKMMIVVVVIFAICWLP 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 266 C---FFTILLDPFLNFSTPAV-LFDALTWFGYFNSTCNPLIYGFFYPWFR 311
Cdd:cd15390 237 YhlyFILTYLYPDINSWKYIQqIYLAIYWLAMSNSMYNPIIYCWMNKRFR 286
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
40-306 1.48e-23

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 98.22  E-value: 1.48e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIF-ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITS 118
Cdd:cd14986   8 GVLFvFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 119 IFHLCSVAVDRFYAICHPLHYCTKMtiPVVRRLLLVCWSVpgAFAFGV----VFSEAyadgiEGYDILVACSSScpvmFN 194
Cdd:cd14986  88 TYILVSMSLDRYQAIVKPMSSLKPR--KRARLMIVVAWVL--SFLFSIpqlvIFVER-----ELGDGVHQCWSS----FY 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 195 KLWGTTLFVAG-----FFTPSSMMVGIYGKIFAV----SKKHARVIDNLPENQNNQ-----------MRKDKKAAK-TLG 253
Cdd:cd14986 155 TPWQRKVYITWlatyvFVIPLIILSYCYGRILRTiwirSRQKTDRPIAPTAMSCRSvscvssrvsliSRAKIKTIKmTLV 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 56605936 254 IVMGvFLLCWFPCFFTILLDPF-LNFSTPAVLFDALTWFGYFNSTCNPLIYGFF 306
Cdd:cd14986 235 IILA-FILCWTPYFIVQLLDVYaGMQQLENDAYVVSETLASLNSALNPLIYGFF 287
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
40-313 1.67e-23

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 98.20  E-value: 1.67e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFITIF-----GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVEN-CWYFGLTFCKIHYSFDLM 113
Cdd:cd14979   4 TAIYVAIFvvgivGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQyPWAFGDGGCKLYYFLFEA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW------SVPGAFAFGVVfSEAYADGIEGYDILVACSS 187
Cdd:cd14979  84 CTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWlvsilcAIPILFLMGIQ-YLNGPLPGPVPDSAVCTLV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 188 SCPVMFNKLWGTTLFVAgFFTPSSMMVGIYGKIFA-----VSKKHARVIDNLP--ENQNNQMRKdKKAAKTLGIVMGVFL 260
Cdd:cd14979 163 VDRSTFKYVFQVSTFIF-FVLPMFVISILYFRIGVklrsmRNIKKGTRAQGTRnvELSLSQQAR-RQVVKMLGAVVIAFF 240
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56605936 261 LCWFPcfFTILLDPFLNFSTPAV-LFDAL-------TWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd14979 241 VCWLP--FHAQRLMFSYASKEDTfLFDFYqylypisGILFYLSSAINPILYNLMSSRFRVA 299
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
36-312 1.72e-23

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 97.76  E-value: 1.72e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15090   5 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGNILCKIVISIDYYNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTiPVVRRLLLVC-WSVPGAFAFGVVF--SEAYADGIEGYDILVACSSScpvM 192
Cdd:cd15090  84 FTSIFTLCTMSVDRYIAVCHPVKALDFRT-PRNAKIVNVCnWILSSAIGLPVMFmaTTKYRQGSIDCTLTFSHPSW---Y 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNKLWGTTLFVAGFFTPSSMMVGIYGkIFAVSKKHARVIDNLPENQNNQMRkdkkAAKTLGIVMGVFLLCWFPCFFTILL 272
Cdd:cd15090 160 WENLLKICVFIFAFIMPVLIITVCYG-LMILRLKSVRMLSGSKEKDRNLRR----ITRMVLVVVAVFIVCWTPIHIYVII 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56605936 273 DPFLNFstPAVLFDALTW-----FGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15090 235 KALVTI--PETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKR 277
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
44-314 2.31e-23

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 97.36  E-value: 2.31e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGF-----TIMPYSMVRSV-ENCWYFGLTFckihysfdLMLSIT 117
Cdd:cd14972  11 FIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIafvftFLSVLLVSLTPsPATWLLRKGS--------LVLSLL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 118 -SIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGydilvACSSSCPvMFNKL 196
Cdd:cd14972  83 aSAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLGWNCVLCDQE-----SCSPLGP-GLPKS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGTTLFVAgFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQN-NQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPF 275
Cdd:cd14972 157 YLVLILVF-FFIALVIIVFLYVRIFWCLWRHANAIAARQEAAVpAQPSTSRKLAKTVVIVLGVFLVCWLPLLILLVLDVL 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 56605936 276 LNFS-TPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd14972 236 CPSVcDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
42-314 2.85e-23

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 97.58  E-value: 2.85e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIF 120
Cdd:cd15202  10 IIVFsLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 121 HLCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCWSVPGAFAfgvvFSEAYADGIEGYDILVACSSSC--------PVM 192
Cdd:cd15202  90 TLTAIAVDRYQAIMHPLK--PRISKTKAKFIIAVIWTLALAFA----LPHAICSKLETFKYSEDIVRSLcledwperADL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNKLWGTTLFVAGFFTPSSMMVGIYGKIfAVSKKHARVIDNLPENQNNQMRKDK-KAAKTLGIVMGVFLLCWFP--CFFT 269
Cdd:cd15202 164 FWKYYDLALFILQYFLPLLVISFAYARV-GIKLWASNMPGDATTERYFALRRKKkKVIKMLMVVVVLFALCWLPfnIYVL 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 56605936 270 ILLD-PFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15202 243 LLSSkPDYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
38-309 3.26e-23

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 97.51  E-value: 3.26e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  38 MACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSIT 117
Cdd:cd15384   7 LAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 118 SIFHLCSVAVDRFYAICHPLhycTKMTIPV-VRRLLLVCWSVPGAFAF--GVVFSEAYADGIEGYDILVACSSSCPVMFN 194
Cdd:cd15384  87 STYITVLISLDRCVAILYPM---KRNQAPErVRRMVTVAWILSPIFSIpqAVIFHVERGPFVEDFHQCVTYGFYTAEWQE 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 195 KLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHAR-----VIDNLPENQNNQ--MRKDK-KAAKTLGIVMGVFLLCWFPC 266
Cdd:cd15384 164 QLYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRdfqglEIYTRNRGPNRQrlFHKAKvKSLRMSAVIVTAFILCWTPY 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56605936 267 FFTILLDPFLNFST-PAVLFDALTWFGYFNSTCNPLIYGFFYPW 309
Cdd:cd15384 244 YVIMIWFLFFNPYPlNDILFDVIFFFGMSNSCVNPLIYGAFHIT 287
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
42-312 5.12e-23

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 96.73  E-value: 5.12e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFH 121
Cdd:cd14992  11 ILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLT 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgafAFGVVFSEAYADGIEGYDILVACSSS-----CPV---MF 193
Cdd:cd14992  91 LTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVV----SLLLAIPQLYYATTEVLFSVKNQEKIfccqiPPVdnkTY 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 194 NKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCF-FTILL 272
Cdd:cd14992 167 EKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKVPGFSIKEVERKRLKCKRRVIKMLVCVVVLFVICWLPFHlFFLLR 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 56605936 273 DPFLNFSTPA---VLFDALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd14992 247 DFFPLIMKEKhtlQVYYFLHWIAMSNSMYNPIIYVTLNNNFRK 289
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
43-319 7.39e-23

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 96.17  E-value: 7.39e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15299  15 LVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNL 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYadgIEGYDILVACSSSCPVMFNKLWGTTLF 202
Cdd:cd15299  95 LVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQY---FVGKRTVPPDECFIQFLSEPIITFGTA 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 203 VAGFFTPSSMMVGIYGKIFavskkharvidnlpenqnNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLNFSTPA 282
Cdd:cd15299 172 IAAFYLPVTIMTILYWRIY------------------KETIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPK 233
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 56605936 283 VLFDALTWFGYFNSTCNPLIYGFFYPWFRRALKYILL 319
Cdd:cd15299 234 TYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLL 270
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
36-314 1.05e-22

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 95.58  E-value: 1.05e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMP-YSMVRSVENCWYFGLTFCKIHYSFDLML 114
Cdd:cd15302   5 LITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPfYTVYVLNGDYWPLGWVLCDLWLSVDYTV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEgyDILVACSSSCPVMFN 194
Cdd:cd15302  85 CLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIFGWQYFTGQG--RSLPEGECYVQFMTD 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 195 KLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKhARvidnlpenqnnqmrkdkKAAKTLGIVMGVFLLCWFPCFFTILLDP 274
Cdd:cd15302 163 PYFNMGMYIGYYWTTLIVMLILYAGIYRAANR-AR-----------------KALRTITFILGAFVICWTPYHILATIYG 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56605936 275 FLNFST--PAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15302 225 FCEAPPcvNETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
33-312 2.03e-22

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 95.28  E-value: 2.03e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIF-ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15981   1 AMFILAYLFIFlLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCWSV------PGAFAFGVVFSEAY--ADGIEGYDILV 183
Cdd:cd15981  81 GMSVSASVFTLVAIAVERFRCIVHPFR--QKLTLRKAIVTIVIIWVLaliimcPSAVTLTVTREEHHfmVDDYNNSYPLY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 184 ACSSSCP-VMFNKLWGTTLFVAGFFTPSSMMVGIYGKI-FAVSKKHARVIDNLPENQNNQM--RKDKKAAKTLGIVMGVF 259
Cdd:cd15981 159 SCWEAWPdTEMRKIYTTVLFSHIYLAPLTLIVIMYARIaFKLFKSSAPIRGSQGEEEEGRRvsKRKIKVINMLIIVALFF 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56605936 260 LLCWFPCFFTILLDPFLNFSTPAV------LFDALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15981 239 TLSWLPLWTLMLLTDYGHLSEDQLnlvtvyVFPFAHWLAFFNSSVNPIIYGYFNENFRR 297
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
44-311 7.79e-22

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 93.46  E-value: 7.79e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFglTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15069  13 LSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDF--HSCLFLACFVLVLTQSSIFSLL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgAFAFGVV-------------FSEAYADGIEGYD-ILVAC---- 185
Cdd:cd15069  91 AVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVL--AFGIGLTpflgwnkamsatnNSTNPADHGTNHScCLISClfen 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 186 --SSSCPVMFNklwgttlFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDnLPENQNNQMRKDKKAAKTLGIVMGVFLLCW 263
Cdd:cd15069 169 vvPMSYMVYFN-------FFGCVLPPLLIMLVIYIKIFLVACRQLQRTE-LMDHSRTTLQREIHAAKSLAIIVGIFALCW 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56605936 264 FPCFF---TILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFR 311
Cdd:cd15069 241 LPVHIlncITLFQPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFR 291
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
46-314 9.15e-22

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 92.72  E-value: 9.15e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  46 IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSV 125
Cdd:cd15001  14 LIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFICSVLTLTAI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 126 AVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFS-EAYADGIEGYDILVACSSSCPVM-FNKLWGTTLFV 203
Cdd:cd15001  94 SIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGqGLVRYESENGVTVYHCQKAWPSTlYSRLYVVYLAI 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 204 AGFFTPSSMMVGIYgkifaVSKKHARVIdnlpenqnnqmrkdkkaaKTLGIVMGVFLLCWFPCFFTILLDPF-----LNF 278
Cdd:cd15001 174 VIFFIPLIVMTFAY-----ARDTRKQVI------------------KMLISVVVLFAVCWGPLLIDNLLVSFdvistLHT 230
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 56605936 279 STPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15001 231 QALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
34-314 1.65e-21

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 92.52  E-value: 1.65e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTD--FLLGFTIMPYSMVRsvENCWYFGLTFCKIHYSFD 111
Cdd:cd15088   3 MPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADllFMLGMPFLIHQFAI--DGQWYFGEVMCKIITALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseaYADGIEGYDILVACSSSCPV 191
Cdd:cd15088  81 ANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWV---YSSLIYFPDGTTFCYVSLPS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLWGTT-LFVAGFFTPSSMMVGIYGKIFavsKKHARVIdnLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTI 270
Cdd:cd15088 158 PDDLYWFTIyHFILGFAVPLVVITVCYILIL---HRLARGV--APGNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQ 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 56605936 271 LLDPFLNFSTPA--VLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15088 233 LVNLAMNRPTLAfeVAYFLSICLGYANSCLNPFVYILVSENFRKRL 278
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
42-312 2.01e-21

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 92.54  E-value: 2.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFI-TIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIF 120
Cdd:cd15205  10 IFVlALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAVVTSIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 121 HLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYAdgiEGYDILVACSSSC------PVMFN 194
Cdd:cd15205  90 TMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLE---VKYDFLYEKRHVCclerwySPTQQ 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 195 KLWGTTLFVAGFFTPSSMMVGIYGKIFAV--SKKHARVIDNLPENQNNQM----RKDKKAAKTLGIVMGVFLLCWFPCFF 268
Cdd:cd15205 167 KIYTTFILVILFLLPLTTMLFLYSRIGYElwIKKRVGDASVLQTIHGIEMskisRKKKRAVKMMVTVVLLFAVCWAPFHV 246
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 269 TILLDPFLNFS------TPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15205 247 VHMMIEYSNLEnkydgvTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFKK 296
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
36-314 3.45e-21

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 91.97  E-value: 3.45e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRS-VENCWYFGLTFCKIHYSFDLM 113
Cdd:cd14997   4 SVVYGVIFVVgVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETwAREPWLLGEFMCKLVPFVELT 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPL---HYCTKMTIPVVrrlLLVCWSVPGAFAFGVVFSEAY--ADGIEGYDILVaCSSS 188
Cdd:cd14997  84 VAHASVLTILAISFERYYAICHPLqakYVCTKRRALVI---IALIWLLALLTSSPVLFITEFkeEDFNDGTPVAV-CRTP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 189 CPVMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHAR-VIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCF 267
Cdd:cd14997 160 ADTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPAlESRRADAANRHTLRSRRQVVYMLITVVVLFFVCLLPFR 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56605936 268 FTILLDPFlnfsTPAVLFDALTWFG------------YFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd14997 240 VVTLWIIF----APDEDLQALGLEGylnllvfcrvmvYLNSALNPILYNLMSTKFRSAF 294
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
46-314 6.69e-21

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 90.93  E-value: 6.69e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  46 IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSV 125
Cdd:cd15336  15 MLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITLLAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 126 AVDRFYAICHPLhycTKMTIPVVRRLLLV---------CWSVPGAFAFGVVFSEAyadgiegydILVACSSS--CPVMFN 194
Cdd:cd15336  95 SLDRYLVITKPL---ASIRWVSKKRAMIIillvwlyslAWSLPPLFGWSAYVPEG---------LLTSCTWDymTFTPSV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 195 KLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNL-------PENQNNQMRKDKKAAKTLGIVMGVFLLCWFP-- 265
Cdd:cd15336 163 RAYTMLLFCFVFFIPLGIIIYCYLFIFLAIRSTGREVQKLgsqdrkeKAKQYQRMKNEWKMAKIAFVVILLFVLSWSPya 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56605936 266 CFFTI-------LLDPFLNfSTPAVLFDAltwfgyfNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15336 243 CVALIawagyahLLTPYMK-SVPAVIAKA-------SAIYNPIIYAITHPKYREAI 290
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
43-314 1.27e-20

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 89.64  E-value: 1.27e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd17790  12 LVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADG---IEGYDILVACSSSCPVMFnklwGT 199
Cdd:cd17790  92 LIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYLVGertVLAGQCYIQFLSQPIITF----GT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 200 TlfVAGFFTPSSMMVGIYGKIFavskkharvidnlpenqnNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLNFS 279
Cdd:cd17790 168 A--IAAFYLPVTIMIILYWRIY------------------RETIKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDC 227
                       250       260       270
                ....*....|....*....|....*....|....*
gi 56605936 280 TPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd17790 228 VPKTLWELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
34-311 1.32e-20

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 90.38  E-value: 1.32e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAI-FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFglTFCKIHYSFDL 112
Cdd:cd15068   2 VYITVELAIaVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAAC--HGCLFIACFVL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDilvACSSSCP-- 190
Cdd:cd15068  80 VLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGK---NHSQGCGeg 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 ---------------VMFNklwgttlFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLP---ENQNNQMRKDKKAAKTL 252
Cdd:cd15068 157 qvaclfedvvpmnymVYFN-------FFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPlpgERARSTLQKEVHAAKSL 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56605936 253 GIVMGVFLLCWFP-----CFftILLDPFLNFSTPAVLFDALTwFGYFNSTCNPLIYGFFYPWFR 311
Cdd:cd15068 230 AIIVGLFALCWLPlhiinCF--TFFCPDCSHAPLWLMYLAIV-LSHTNSVVNPFIYAYRIREFR 290
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
41-314 1.44e-20

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 90.07  E-value: 1.44e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  41 AIFITI------FGNLAMIISISYFKQLHTPTNLLILSMAVTDFllGFTIM---PYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15337   4 GIYIAIvgilgvIGNLLVIYLFSKTKSLRTPSNMFIINLAISDF--GFSAVngfPLKTISSFNKKWIWGKVACELYGFAG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLV------CWSVPGAFAFGVVFSEAYADGIEgYDILvac 185
Cdd:cd15337  82 GIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIiwlwslLWSIPPFFGWGRYVPEGFQTSCT-FDYL--- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 186 SSSCPvmfNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPEN--------QNNQMRKDKKAAKTLGIVMG 257
Cdd:cd15337 158 SRDLN---NRLFILGLFIFGFLCPLLIIIFCYVNIIRAVRNHEKEMTQTAKSgmgkdtekNDARKKAEIRIAKVAIILIS 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56605936 258 VFLLCWFP----CFFTILldPFLNFSTPAVLfDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15337 235 LFLLSWTPyavvALLGQF--GPAYWITPYVS-ELPVMFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
32-314 1.69e-20

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 89.86  E-value: 1.69e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDfLLGFTIMPYSMVRSVE-NCWYFGLTFCKIHYSF 110
Cdd:cd15928   1 AAVTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSD-LLIFLVLPLDLYRLWRyRPWRFGDLLCRLMYFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 111 DLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSV------PGAFAFGV--VFSEAYADGIEGYDIL 182
Cdd:cd15928  80 SETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVaivsagPALVLVGVehIQGQQTPRGFECTVVN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 183 VAcSSSCPVMfnkLWGTTLFvagFFTPS---SMMVGIYGKIFAVSKKHARVIDNLPENQNNqmrkdKKAAKTLGIVMGVF 259
Cdd:cd15928 160 VS-SGLLSVM---LWVSTSF---FFVPMvclSLLYGLIGRALWDRRQRSRTAGASRRDNNH-----RQTVRMLAVIVLAF 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56605936 260 LLCWFP-------CFFTILLDPFLNFSTPAVLFDALTWFgYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15928 228 VLCWLPfhvgrviFNHSRASTKHLHYVSQYFNLVSFVLF-YLSAAINPILYNLMSKRYRYAV 288
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
36-314 3.69e-20

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 88.93  E-value: 3.69e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIhYSFDL-ML 114
Cdd:cd15083   5 IFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDM-YGFSGgLF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPLHYCTKMTIpvvRRLLLVC---------WSVPGAFAFGvvfseAYAdgIEGYdiLVAC 185
Cdd:cd15083  84 GIMSINTLAAIAVDRYLVITRPMKASVRISH---RRALIVIavvwlysllWVLPPLFGWS-----RYV--LEGL--LTSC 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 186 S----SSCPvmFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQM--------RKDKKAAKTLG 253
Cdd:cd15083 152 SfdylSRDD--ANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMAKRFSKSElsspkarrQAEVKTAKIAL 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56605936 254 IVMGVFLLCWFPCFFTILLDPF--LNFSTPAVLFDAlTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15083 230 LLVLLFCLAWTPYAVVALIGQFgyLEVLTPLATAIP-AAFAKTSAIYNPVIYAFSHPKFRRAL 291
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
40-314 4.57e-20

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 88.54  E-value: 4.57e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENC-WYFGLTFCKIHYSFDLMLSIT 117
Cdd:cd15134   8 GIIFVTgVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYpWVFGEVFCKLRAFLSEMSSYA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 118 SIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFA--FGVVFSEAYADGIEGYDILVACSSSCPVMFNK 195
Cdd:cd15134  88 SVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCAlpFAIQTRIVYLEYPPTSGEALEESAFCAMLNEI 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 196 LWGTTLFVAG----FFTPSSMMVGIYGKIfAVSKKHARVIDNLPEN---QNNQMRKDKKAAKTLGIVMGVFLLCWFPCFF 268
Cdd:cd15134 168 PPITPVFQLStflfFIIPMIAIIVLYVLI-GLQLRRSTLLRRGQRSvsgGRRSSQSRRTVLRMLVAVVVAFFICWAPFHA 246
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56605936 269 TILLDPFLNFSTPAVLFdALTW-------FGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15134 247 QRLLTVYAKNMTPPYLF-INRIlfyisgvLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
36-313 8.02e-20

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 87.87  E-value: 8.02e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15000   4 SMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAY-----ADGIEGYdilvaCSSSCP 190
Cdd:cd15000  84 LASVLALCAVSYDRLTAIVLPSE--ARLTKRGAKIVIVITWIVGLLLALPLAIYRSYrerqwKNFLETY-----CAENTQ 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 VMfNKLWgTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIdnLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPcfFTI 270
Cdd:cd15000 157 VL-PIYW-HVIITVLVWLPLGIMLICYSAIFWKLDKYERRV--LRREHPSVVRYKKKAAKTLFIVLITFVVCRIP--FTA 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 56605936 271 LL---------DPFLNFSTPA--VLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15000 231 LIfyryklvpnDNTQNSVSGSfhILWFASKYLMFLNAAVNPLIYGFTNENFRKA 284
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
33-312 1.48e-19

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 86.93  E-value: 1.48e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMacaIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGfTIMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15091   5 AVYSVV---FVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVT-TTMPFQSTVYLMNSWPFGDVLCKIVISIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTiPVVRRLLLVC-WSVPG-----AFAFGVVFSEAYADGIEgydilvaCS 186
Cdd:cd15091  81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT-PLKAKIINICiWLLSSsvgisAIVLGGTKVREDVDSTE-------CS 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 187 SSCPVMFNKLWGTTL----FVAGFFTPSSMMVGIYgKIFAVSKKHARVIDNLPENQNNQMRkdkkAAKTLGIVMGVFLLC 262
Cdd:cd15091 153 LQFPDDDYSWWDTFMkicvFIFAFVIPVLIIIVCY-TLMILRLKSVRLLSGSREKDRNLRR----ITRLVLVVVAVFVVC 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56605936 263 WFPCFFTILLDPFLNFSTPAVLFDALTW---FGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15091 228 WTPIHIFILVEALGSVSHSTAAVSSYYFciaLGYTNSSLNPILYAFLDENFKR 280
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
37-314 4.83e-19

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 85.71  E-value: 4.83e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFIT----IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15079   2 LLGFIYIFLgivsLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIK-MPIFIYNSFYEGWALGPLGCQIYAFLGS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHyCTKMTIPVVRRLLLVCWSVPGAFA---FGVVFSEAYADGiegydILVACSSSc 189
Cdd:cd15079  81 LSGIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWAllpLLFGWGRYVPEG-----FLTSCSFD- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 190 pvMFNKLWGTTLFVAGFFT-----PSSMMVGIYGKIFAVSKKHAR----------VIDNLPENQNNQMRKDKKAAKTLGI 254
Cdd:cd15079 154 --YLTRDWNTRSFVATIFVfayviPLIIIIYCYSFIVKAVFAHEKalreqakkmnVVSLRSNADANKQSAEIRIAKVALT 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56605936 255 VMGVFLLCWFPCFFTILLDPFLNFS--TPAV-LFDALtwFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15079 232 NVFLWFIAWTPYAVVALIGAFGNQSllTPLVsMIPAL--FAKTAACYNPIVYAISHPKYRLEL 292
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
37-314 6.27e-19

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 85.40  E-value: 6.27e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIfITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd15074   7 LTVIGI-LSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICHPlHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYAdGIEGYDIlvacssSCPVMFNKL 196
Cdd:cd15074  86 CSINTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSY-GPEPFGT------SCSIDWTGA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGTT--------LFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFP--- 265
Cdd:cd15074 158 SASVggmsyiisIFIFCYLLPVLIIVFSYVKIIRKVKSSRKRVAGFDSRSKRQHKIERKVTKVAVLICAGFLIAWTPyav 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 266 -CFFTILLDPflnFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15074 238 vSMWSAFGSP---DSVPILASILPALFAKSSCMYNPIIYLLFSSKFRQDL 284
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
37-314 9.32e-19

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 84.99  E-value: 9.32e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYfKQLHTPTNLLILSMAVTDFLLGFTIMPYSMV---RSVENCWYFGLT--FCKIHYSFD 111
Cdd:cd14978   6 VLPVICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDILVLLSALPLFLLpyiADYSSSFLSYFYayFLPYIYPLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW------SVPGAFAFGVVFSEAYADGIEGYDILVAC 185
Cdd:cd14978  85 NTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIifslllNLPRFFEYEVVECENCNNNSYYYVIPTLL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 186 S-SSCPVMFNKLWGTTLFVagFFTPSSMMVGIYGK-IFAV--SKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLL 261
Cdd:cd14978 165 RqNETYLLKYYFWLYAIFV--VLLPFILLLILNILlIRALrkSKKRRRLLRRRRRLLSRSQRRERRTTIMLIAVVIVFLI 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 56605936 262 CWFPCFFTILL----DPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd14978 243 CNLPAGILNILeaifGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
33-314 1.46e-18

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 83.92  E-value: 1.46e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15300   2 TIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEgydilVACSSSCPVM 192
Cdd:cd15300  82 VASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILCWQYFVGKR-----TVPERECQIQ 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 F----NKLWGTTlfVAGFFTPSSMMVGIYGKIFavskkharvidnlpenqnNQMRKDKKAAKTLGIVMGVFLLCWFPCFF 268
Cdd:cd15300 157 FlsepTITFGTA--IAAFYIPVSVMTILYCRIY------------------KETIKERKAAQTLSAILLAFIITWTPYNI 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 56605936 269 TILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15300 217 MVLVSTFCSDCIPLTLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
32-312 1.51e-18

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 84.33  E-value: 1.51e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRS-VENCWYFGLTFCKIHYSF 110
Cdd:cd15392   1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALlILQYWPFGEFMCPVVNYL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 111 DLMLSITSIFHLCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCP 190
Cdd:cd15392  81 QAVSVFVSAFTLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFALATALPIAITSRLFEDSNASCGQYICTESWP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 -VMFNKLWGTTLFVAGFFTPSSMMVGIYGKIfAVSKKHARVIDNLPENQNNQMRKDK-KAAKTLGIVMGVFLLCWFPC-F 267
Cdd:cd15392 159 sDTNRYIYSLVLMILQYFVPLAVLVFTYTRI-GIVVWAKRTPGEAENNRDQRMAESKrKLVKMMITVVAIFALCWLPLnI 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56605936 268 FTILLD---PFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15392 238 LNLVGDhdeSIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRN 285
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
34-306 1.77e-18

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 83.63  E-value: 1.77e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLM 113
Cdd:cd14964   1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPgafafgVVFSEAYADGIEGYDILVACSSSCPVMF 193
Cdd:cd14964  81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVS------LLLSIPPLVGKGAIPRYNTLTGSCYLIC 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 194 NKLWGTTLFVAGFFTPSSMMVGIYGkiFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLD 273
Cdd:cd14964 155 TTIYLTWGFLLVSFLLPLVAFLVIF--SRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFILH 232
                       250       260       270
                ....*....|....*....|....*....|....
gi 56605936 274 PFLNFSTPA-VLFDALTWFGYFNSTCNPLIYGFF 306
Cdd:cd14964 233 ALVAAGQGLnLLSILANLLAVLASTLNPFIYCLG 266
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
34-314 2.10e-18

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 83.65  E-value: 2.10e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAifiTIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLG-FTIMPySMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15012   5 LYTLVFCC---CFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGiFCVLQ-NLSIYLIPSWPFGEVLCRMYQFVHS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFG-VVFSE--AYADGIEGYDILVaCSSSC 189
Cdd:cd15012  81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPyFVFSQtvEILVTQDGQEEEI-CVLDR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 190 PVMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVidnlpenqnnqmRKDKKAAKTLGIVMGVFLLCWFPCF-- 267
Cdd:cd15012 160 EMFNSKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSI------------EARRKVVRLLVAVVVSFALCNLPYHar 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 268 --FTILLDPFLNFSTPAVLFDALTW-FGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15012 228 kmWQYWSEPYRCDSNWNALLTPLTFlVLYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
33-312 5.66e-18

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 82.69  E-value: 5.66e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMaCAIfiTIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15089   5 ALYSVV-CVV--GLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTiPVVRRLLLVC-WSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPV 191
Cdd:cd15089  81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT-PAKAKLINICiWVLSSGVGVPIMVMAVTKTPRDGAVVCMLQFPSPSW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLWGTTLFVAGFFTPSSMMVGIYGkIFAVSKKHARVIDNLPENQNNQMRkdkkAAKTLGIVMGVFLLCWFPCFFTIL 271
Cdd:cd15089 160 YWDTVTKICVFIFAFVVPILVITVCYG-LMILRLRSVRLLSGSKEKDRNLRR----ITRMVLVVVAAFIICWTPIHIFVI 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56605936 272 LDPFLNFSTPAVLFDALTWF----GYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15089 235 VWTLVDIDRRNPLVVAALHLcialGYANSSLNPVLYAFLDENFKR 279
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
42-313 7.73e-18

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 82.34  E-value: 7.73e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFH 121
Cdd:cd15096  11 FIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYT 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLhycTKMTIPVVRRLLL---VCWSV------PGAFAFGVVFseayadgiegYDILVACSSSCPVM 192
Cdd:cd15096  91 LVLMSLDRYLAVVHPI---TSMSIRTERNTLIaivGIWIVilvaniPVLFLHGVVS----------YGFSSEAYSYCTFL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNKLWG-----TTLFVAGFFTPSSMMVGIYGKI-FAVSKKHARVIDNLPENQnnqmRKDKKAAKTLGIVMGVFLLCWFPc 266
Cdd:cd15096 158 TEVGTAaqtffTSFFLFSYLIPLTLICVLYMLMlRRLRRQKSPGGRRSAESQ----RGKRRVTRLVVVVVVVFAICWLP- 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56605936 267 FFTILLDPFLNFSTPAVLFDALT----WFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15096 233 IHIILLLKYYGVLPETVLYVVIQilsnCLAYGNSCVNPILYAFLSQNFRKA 283
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
36-314 9.04e-18

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 81.52  E-value: 9.04e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIfGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15214   5 AIIIIAILICL-GNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLIS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW------SVPGAFAFGVVFSEAYadgiegydilvacSSSC 189
Cdd:cd15214  84 SASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWlhsligCLPPLFGWSSLEFDRF-------------KWMC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 190 PVMFNKLWGTTLF--VAGFFTPSSMMVGIYGKIFAVSKKharvidnlpenqnNQMrkdkKAAKTLGIVMGVFLLCWFPCF 267
Cdd:cd15214 151 VAAWHKEAGYTAFwqVWCALLPFVVMLVCYGFIFRVARA-------------NQC----KAFITILVVLGAFVTTWGPYM 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56605936 268 FTILLDPFLNFSTPAVLFDAL-TWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15214 214 VVISTEALWGKNSVSPQLETLaTWLSFTSAVCHPLIYGLWNKTVRKEL 261
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
34-314 1.34e-17

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 81.71  E-value: 1.34e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMacaIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVE-NCWYFGLTFCKIHYSFDL 112
Cdd:cd15394   6 LYSLV---VLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEpRGWVFGRFMCYFVFLMQP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIeGYDILVaCSSSCPVM 192
Cdd:cd15394  83 VTVYVSVFTLTAIAVDRYYVTVYPLR--RRISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFK-GLDFSI-CEEFWFGQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNK--LWGTTLFVAGFFTPSSMMVGIYGKIfAVSKKHARVIDNL-PENQNNQMRKDKKAAKTLGIVMGVFLLCWFPC-FF 268
Cdd:cd15394 159 EKQrlAYACSTLLITYVLPLLAISLSYLRI-SVKLRNRVVPGSMtQSQAEWDRARRRKTFRLLVVVVVAFAICWLPLhIF 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56605936 269 TILLDPFLNFSTP-AVLFDALT--WFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15394 238 NVIRDIDIDLIDKqYFNLIQLLchWLAMSSACYNPFLYAWLHDSFRGEL 286
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
43-312 1.42e-17

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 81.69  E-value: 1.42e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIhYSFDLMLSIT-SIFH 121
Cdd:cd15393  12 LVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPF-CPFVQVLSVNvSVFT 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLhyCTKMTIPVVRRLLLVCW------SVPGAFAFGVV-FSEAYADGIEGYDILVACSSSCPVMFN 194
Cdd:cd15393  91 LTVIAVDRYRAVIHPL--KARCSKKSAKIIILIIWilallvALPVALALRVEeLTDKTNNGVKPFCLPVGPSDDWWKIYN 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 195 klwgTTLFVAGFFTPSSMMVGIYGKIfAVSKKHARVIDNLPENQNNQMRKDK-KAAKTLGIVMGVFLLCWFPcfftILLD 273
Cdd:cd15393 169 ----LYLVCVQYFVPLVIICYAYTRI-AVKIWGTKAPGNAQDVRDDEILKNKkKVIKMLIIVVALFALCWLP----LQTY 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56605936 274 PFLNFSTPA--------VLFDALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15393 240 NLLNEIKPEinkykyinIIWFCSHWLAMSNSCYNPFIYGLYNEKFKR 286
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
39-314 2.07e-17

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 80.67  E-value: 2.07e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  39 ACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTImPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITS 118
Cdd:cd15973   8 ALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSV-PFLAASAALQHWPFGSAMCRTVLSVDGINMFTS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 119 IFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseaYADGIEGYDILVACSSSCPvmfNKLWG 198
Cdd:cd15973  87 VFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIII---FADTATRKGQAVACNLIWP---HPAWS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 199 TTL----FVAGFFTPSSMM----VGIYGKIFAVSKKharvidnlpENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTI 270
Cdd:cd15973 161 AAFviytFLLGFLLPVLAIglcyILIIGKMRAVALK---------AGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQ 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56605936 271 LLDPFLNfSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15973 232 LLNLFLP-RLDATVNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
46-314 2.58e-17

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 80.79  E-value: 2.58e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  46 IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIH-YSFDLMLSITSIfHLCS 124
Cdd:cd15095  15 LAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVnYMMQVTVQATCL-TLTA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 125 VAVDRFYAICHPLhycTKMTIPVVRRLLLVC---W------SVPGAFAFGVVfsEAYADGIEGYDILVACSSscpvMFNK 195
Cdd:cd15095  94 LSVDRYYAIVHPI---RSLRFRTPRVAVVVSaciWivsfllSIPVAIYYRLE--EGYWYGPQTYCREVWPSK----AFQK 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 196 LWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPEN-QNNQMRKDKKAAKTLGIVMGVFLLCWFPC-FFTILLD 273
Cdd:cd15095 165 AYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDGNNQSEQlSERALRQKRKVTRMVIVVVVLFAICWLPNhVLNLWQR 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56605936 274 PFLNFSTPAVLFDALTW---FGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15095 245 FDPNFPETYATYALKIAalcLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
44-313 2.63e-17

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 80.60  E-value: 2.63e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTD--FLLGftiMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFH 121
Cdd:cd15094  13 VGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADecFLIG---LPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSSFT 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKLWGTTL 201
Cdd:cd15094  90 LTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPDSSAVNGQKAFTLYT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 202 FVAGFFTPSSMMVGIYgkiFAVSKKHARVidnLPENQNNQMRKD-KKAAKTLGIVMGVFLLCWFPCFFT----ILLDPFL 276
Cdd:cd15094 170 FLLGFAIPLLLISVFY---TLVILRLRTV---GPKNKSKEKRRShRKVTRLVLTVISVYIICWLPYWAFqvhlIFLPPGT 243
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 56605936 277 NFSTPAVL-FDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15094 244 DMPKWEILmFLLLTVLSYANSMVNPLLYAFLSENFRKS 281
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
30-314 2.87e-17

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 80.63  E-value: 2.87e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  30 VRAAMYSLMacaIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKI-HY 108
Cdd:cd15979   2 VRILLYSVI---FLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAvAY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 109 SFDLMLSItSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFG-VVFSEAYADGIEGYDILVACSS 187
Cdd:cd15979  79 LMGVSVSV-STFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPyPVYSVTVPVPVGDRPRGHQCRH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 188 SCP-VMFNKLWGTTLFVAGFFTPSSMMVGIYGKIfavSKKHARvidnlpenqnnQMRKDKKAAKTLGIVMGVFLLCWFPC 266
Cdd:cd15979 158 AWPsAQVRQAWYVLLLLILFFIPGVVMIVAYGLI---SRELYR-----------GLLAKKRVIRMLVVIVAMFFLCWLPI 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56605936 267 FFTILLDPFLNFSTPAVLFDALTWF----GYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15979 224 FSANTWRAFDPLSAHRALSGAPISFihllSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
43-314 3.38e-17

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 80.34  E-value: 3.38e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTImPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15970  12 LVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSV-PFLVTSTLLRHWPFGSLLCRLVLSVDAINMFTSIYCL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYdilVACSSSCPVMFNKlWGTTL- 201
Cdd:cd15970  91 TVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDGS---VACNMQMPEPSQR-WLAVFv 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 202 ---FVAGFFTPSSMMVGIYgkIFAVSKkhARVIdNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLNf 278
Cdd:cd15970 167 vytFLMGFLLPVIAICLCY--ILIIVK--MRVV-ALKAGWQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLVSVFVG- 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 56605936 279 STPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15970 241 QHDATVSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
37-304 4.68e-17

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 79.80  E-value: 4.68e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTptNLLILSMAVTDFLLGFTIMPYSMV--RSVENCWYFGLTFCKIHYSFDLML 114
Cdd:cd15220   5 CMVLLDLTALVGNTAVMVVIAKTPHLRK--FAFVCHLCVVDLLAALLLMPLGILssSPFFLGVVFGEAECRVYIFLSVCL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGieGYDILVACSSSCPV--- 191
Cdd:cd15220  83 VSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYGG--PAPIAARHCSLHWShsg 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 ---MFNKLWGTTLFVAgfftPSSMMVGIYGKIFAVskkharvidnLPENqnnqmrkdkKAAKTLGIVMGVFLLCWFPcFF 268
Cdd:cd15220 161 hrgVFVVLFALVCFLL----PLLLILVVYCGVFKV----------FGGG---------KAALTLAAIVGQFLCCWLP-YF 216
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 56605936 269 TILLDPFLNFS--TPAVLFDALTWFGYFNSTCNPLIYG 304
Cdd:cd15220 217 AFHLYSALAASpvSGGEAEEVVTWLAYSCFAVNPFFYG 254
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
37-314 5.83e-17

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 79.87  E-value: 5.83e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd15391   6 LYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICHPLHY-CTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYdilVACSSSCPVMFNK 195
Cdd:cd15391  86 ASVLTNTAIGIDRFFAVIFPLRSrHTKSRTKCIIASIWAISFSLSSVQLFAGRTQRYGQYSEGR---VLCGESWPGPDTS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 196 LWGTTLFV--AGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLD 273
Cdd:cd15391 163 RSAYTVFVmlLTYIIPLLILTSTYGYVGFRLWNRTAPGNADKGRDDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFNLVQ 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56605936 274 PF------LNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15391 243 DFstvfrnMPQHTTRLIYGACHWIAMSNSFVNPIIYLFMNDSFRSIL 289
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
43-314 1.04e-16

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 78.85  E-value: 1.04e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15297  12 LVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGA-FAFGVVFSEAYADG--IEGYDILVACSSSCPVMFnklwGT 199
Cdd:cd15297  92 LIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFIlWAPAILFWQFIVGGrtVPEGECYIQFFSNAAVTF----GT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 200 TlfVAGFFTPSSMMVGIYGKIfavSKKHARvidnlpenqnnqmrkDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLNFS 279
Cdd:cd15297 168 A--IAAFYLPVIIMTVLYWQI---SRASSR---------------EKKVTRTILAILLAFIITWTPYNVMVLINTFCASC 227
                       250       260       270
                ....*....|....*....|....*....|....*
gi 56605936 280 TPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15297 228 IPNTVWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
40-314 2.17e-16

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 78.11  E-value: 2.17e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFIT-IFGNlAMIISISYFKQLHTPTNLLILSMAVTDFL--LGFTIMPYSMVRSveNCWYFGLTFCKIHySFDLMLSI 116
Cdd:cd14974   8 ALIFLLgLPGN-GLVIWVAGFKMKRTVNTVWFLNLALADFLfcLFLPFLIVYIAMG--HHWPFGSVLCKLN-SFVISLNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 -TSIFHLCSVAVDRFYAICHPLhYCTKmtipvVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNK 195
Cdd:cd14974  84 fASVFLLTAISLDRCLLVLHPV-WAQN-----HRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTCVEDY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 196 LWGTTL--------FVAGFFTPSSMMVGIYGKIFAVSKKharvidnlpenqnNQMRKDKKAAKTLGIVMGVFLLCWFPCF 267
Cdd:cd14974 158 DLRRSRhkaltvirFLCGFLLPLLIIAICYSVIAVKLRR-------------KRLAKSSKPLRVLLAVVVAFFLCWLPYH 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 268 FTILLDPFLNFSTPAVLFDAL---TWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd14974 225 VFALLELVAAAGLPEVVLLGLplaTGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
32-303 2.32e-16

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 77.96  E-value: 2.32e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMacaIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd16004   4 AIAYSLI---VLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCWSVpgafAFGVVFSEAYADGIEGYDILVACSSSCPV 191
Cdd:cd16004  81 ITAMFVSIYSMTAIAADRYMAIIHPFK--PRLSAGSTKVVIAGIWLV----ALALAFPQCFYSTVTMDQGRTKCIVAWPG 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNK----LWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCF 267
Cdd:cd16004 155 DSGGkhqlTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQAHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYH 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 56605936 268 FTILLDPFLN----FSTPAVLFDALTWFGYFNSTCNPLIY 303
Cdd:cd16004 235 LYFILGSFNEdiycQKYIQQVYLAIFWLAMSSTMYNPIIY 274
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
32-313 2.58e-16

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 77.52  E-value: 2.58e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15296   1 VILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTK--MTIPVVRRLLLVCWSVPGAFAFGVVFSEAyadgIEGYDILVACSSSC 189
Cdd:cd15296  81 YLLCTASVFNIVLISYDRFLSVTRAVSYRAQkgMTRQAVLKMVLVWVLAFLLYGPAIISWEY----IAGGSIIPEGECYA 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 190 PVMFNKLWGTTLFVAGFFTP----SSMMVGIYGKIfavskkharvidnlpENQNNQMRKDKKAAKTLGIVMGVFLLCWFP 265
Cdd:cd15296 157 EFFYNWYFLMTASTLEFFTPfisvTYFNLSIYLNI---------------QKRRFRLSRDKKVAKSLAIIVCVFGLCWAP 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56605936 266 -CFFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15296 222 yTLLMIIRAACHGHCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRRA 270
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
44-314 2.79e-16

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 77.53  E-value: 2.79e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYF---GLTFCKIHYSFDLMLSIT--- 117
Cdd:cd15103  13 VSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLvprDSFEQHIDNVIDSMICSSlla 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 118 SIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFafGVVFseayadgiegydilVACSSSCPVMFnklw 197
Cdd:cd15103  93 SICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVC--GILF--------------IIYSDSVPVII---- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 198 gttLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLN 277
Cdd:cd15103 153 ---CLISMFFAMLVLMASLYVHMFLLARSHVKKIAALPGQRSTRQRANMKGAVTLTILLGVFIFCWAPFFLHLTLMISCP 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 56605936 278 FSTPAVLFDALtwFGYF------NSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15103 230 SNPYCACYMSH--FNVYlilimcNSVIDPLIYAFRSQELRKTF 270
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
35-313 3.51e-16

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 76.92  E-value: 3.51e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  35 YSLMACAIFITI---FGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15210   1 YFAAVWGIVFMVvgvPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAyadGIEGYDILVACSSSCPV 191
Cdd:cd15210  81 YGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGIW---GRFGLDPKVCSCSILRD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLWGTTLFVAGFFTPSSMMVGIYGKifavskkharvidnlpenqnnqmRKDKKAAKTLGIVMGVFLLCWFPCFFTIL 271
Cdd:cd15210 158 KKGRSPKTFLFVFGFVLPCLVIIICYAR-----------------------REDRRLTRMMLVIFLCFLVCYLPITLVNV 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56605936 272 LDPflnFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15210 215 FDD---EVAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYRQA 253
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
44-314 4.97e-16

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 76.80  E-value: 4.97e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15008  12 VSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVLL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 124 SVAVDRFYAICHPLHYctKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGiEGYDILVACSSScpvmfNKLWGTTLFV 203
Cdd:cd15008  92 SICVDRFYTIVYPLSF--KVSREKAKKMIAASWLFDAAFVSPALFFYGSNWG-PHCNFFLPDSWD-----GAAYAIIHLL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 204 AGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLN-FSTPA 282
Cdd:cd15008 164 VGFLVPSILIILFYQKVIKYIWRIGTDGRTVRRTMNIVPRTKVKTIKMFLMLNSMFLLSWLPFYVVQLWHPRESdYRQSS 243
                       250       260       270
                ....*....|....*....|....*....|..
gi 56605936 283 VLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15008 244 LVFLAVTWISFSSSASKPTLYSVYNANFRRGM 275
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
43-312 5.12e-16

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 77.12  E-value: 5.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTD--FLLGftiMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIF 120
Cdd:cd15093  12 LVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADelFMLG---LPFLAASNALRHWPFGSVLCRLVLSVDGINMFTSIF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 121 HLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseaYADGIEGYDILVACSSSCPVMFNKlWGTT 200
Cdd:cd15093  89 CLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVV---FAGTRENQDGSSACNMQWPEPAAA-WSAG 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 201 L----FVAGFFTPSSMM----VGIYGKIFAVSKKHARvidnlpenqNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILL 272
Cdd:cd15093 165 FiiytFVLGFLLPLLIIclcyLLIVIKVKSAGLRAGW---------QQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLV 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 56605936 273 DPFLNFS-TPAV--LFDALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15093 236 NVFVQLPeTPALvgVYHFVVILSYANSCANPILYGFLSDNFKK 278
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
44-314 1.07e-15

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 75.93  E-value: 1.07e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDflLGFTIM--PYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFH 121
Cdd:cd15073  13 ISTISNGIVLVTFVKFRELRTPTNALIINLAVTD--LGVSIIgyPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHYCtKMTIPVVRRLLLVCWSvpgafaFGVVFSEAYADGIEGYDILVAcSSSCPVMFNK------ 195
Cdd:cd15073  91 LTVVAVDRYLTICRPDLGR-KMTTNTYTVMILLAWT------NAFFWAAMPLVGWASYALDPT-GATCTINWRKndssfv 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 196 LWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARviDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPF 275
Cdd:cd15073 163 SYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLA--SDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVCLWASF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 56605936 276 LNFSTPAVLFDALTWFGYFNSTC-NPLIYGFFYPWFRRAL 314
Cdd:cd15073 241 GEPKKIPPWMAIIPPLFAKSSTFyNPCIYVIANKKFRRAI 280
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
42-314 1.16e-15

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 76.01  E-value: 1.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHySFDLMLSIT-SIF 120
Cdd:cd15395  11 IILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLN-SMVQCISITvSIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 121 HLCSVAVDRFYAICHPL-------HYCtkMTIPVVRRLLLVCwSVPgAFAFGVVFSEAYADG---IEGYDILVACSSSCP 190
Cdd:cd15395  90 SLVLIAIERHQLIINPRgwrpnnrHAY--VGIAVIWVLAVLT-SLP-FLIFQVLTDEPFKNVnvsLDAYKGKYVCLDQFP 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 VMFNKL-WGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGvFLLCWFPCF-F 268
Cdd:cd15395 166 SDTIRLsYTTCLLVLQYFGPLCFIFICYLKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLISIVVA-FAVCWLPLNiF 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 269 TILLD---PFLNFSTPAVLFdALTWFGYFNSTC-NPLIYGFFYPWFRRAL 314
Cdd:cd15395 245 NAVFDwnhEAIATCNHNLLF-LICHLTAMISTCvNPIFYGFLNKNFQRDL 293
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
46-313 1.94e-15

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 75.53  E-value: 1.94e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  46 IFGNlAMIISI---SYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCK-IHYSFDLMLsITSIFH 121
Cdd:cd15098  15 VLGN-SLVITVlarVKPGKRRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKfVHYFFTVSM-LVSIFT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKLWGTTL 201
Cdd:cd15098  93 LVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTASNQTFCWENWPEKQQKPVYVVCT 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 202 FVAGFFTPSSMMVGIYgkifavskkhARVIDNLPENQNNQMRK----DKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLN 277
Cdd:cd15098 173 FVFGYLLPLLLITFCY----------AKVLNHLHKKLKNMSKKsersKKKTAQTVLVVVVVFGISWLPHHIIHLWVEFGD 242
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 56605936 278 F---STPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15098 243 FpltQASFVLRITAHCLAYANSCVNPIIYAFLSENFRKA 281
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
41-313 2.36e-15

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 75.20  E-value: 2.36e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  41 AIFITIF-----GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd14971   5 LFFALIFllglvGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYdiLVACSSSCPVMFNK 195
Cdd:cd14971  85 HASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGN--RTVCSEAWPSRAHR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 196 L-WGTTLFVAGFFTPSSMMVGIYGKIFavsKKHARVIDNLPENQNNQmRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDP 274
Cdd:cd14971 163 RaFALCTFLFGYLLPLLLICVCYAAML---RHLWRVAVRPVLSEGSR-RAKRKVTRLVLVVVVLFAACWGPIHAILLLVA 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56605936 275 FLNFSTPAVLFDALTW---FGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd14971 239 LGPFPLTYATYALRIWahcLAYSNSAVNPVLYAFLSEHFRKA 280
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
48-314 2.67e-15

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 75.10  E-value: 2.67e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  48 GNLAMIISISY-FKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVA 126
Cdd:cd15383  17 SNLAVLWSATRnRRRKLSHVRILILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSSAFVTVVIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 127 VDRFYAICHPLhyCTKMTIPVVRRLLLVCW------SVPGAFAFGVVFSEAYADgiegydiLVACSSSCPvmFNKLWGTT 200
Cdd:cd15383  97 LDRHAAILNPL--AIGSARRRNRIMLCAAWglsallALPQLFLFHTVTATPPVN-------FTQCATHGS--FPAHWQET 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 201 L-----FVAGFFTPSSMMVGIYGKIF-AVSKKHARVIDNLPEN------QNNQMRKDKKAAKTLGIVMGVFLLCWFPCF- 267
Cdd:cd15383 166 LynmftFFCLFLLPLLIMIFCYTRILlEISRRMKEKKDSAKNEvalrssSDNIPKARMRTLKMTIVIVSSFIVCWTPYYl 245
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 268 --FTILLDP-FLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15383 246 lgLWYWFSPeMLEQTVPESLSHILFLFGLLNACLDPLIYGLFTISFRRGL 295
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
33-314 2.95e-15

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 74.56  E-value: 2.95e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLmacaIFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVrSVENCWYFGLTFCKIHYSFD 111
Cdd:cd14984   5 VLYSL----VFLLgLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLT-LPFWAV-YAADGWVFGSFLCKLVSALY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAF-GVVFSEAYadgiEGYDILVaCSSSCP 190
Cdd:cd14984  79 TINFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLpEFIFSQVS----EENGSSI-CSYDYP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 VMFNKLWGTTL----FVAGFFTPSSMMVGIYGKIFAVSKKharvidnlpenqnNQMRKDKKAAKTLGIVMGVFLLCWFPC 266
Cdd:cd14984 154 EDTATTWKTLLrllqNILGFLLPLLVMLFCYSRIIRTLLR-------------ARNHKKHRALRVIFAVVVVFFLCWLPY 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 56605936 267 FFTILLDPFLNF-------STPAVLFDALTW---FGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd14984 221 NIVLLLDTLQLLgiisrscELSKSLDYALQVtesLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
46-312 2.99e-15

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 74.90  E-value: 2.99e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  46 IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSV 125
Cdd:cd15092  15 LVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLT-LPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAM 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 126 AVDRFYAICHPLHyCTKMTIPVVRRLLLVC-WSVPGAFAFGVVFSEAYADGIEGYDILVACSSscPVMF-NKLWGTTLFV 203
Cdd:cd15092  94 SVDRYVAICHPIK-ALDVRTPHKAKVVNVCiWALASVVGVPVMVMGSAQVEDEEIECLVEIPT--PQDYwDPVFGICVFL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 204 AGFFTPSSMMVGIYGKIFAVSKKhARVIDNLPENQNNQMRkdkkAAKTLGIVMGVFLLCWFPCFFTILLDPfLNFSTPAV 283
Cdd:cd15092 171 FSFIIPVLIISVCYSLMIRRLRG-VRLLSGSKEKDRNLRR----ITRLVLVVVAVFVGCWTPIQIFVLAQG-LGVQPSSE 244
                       250       260       270
                ....*....|....*....|....*....|...
gi 56605936 284 LFDALTWF----GYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15092 245 TAVAILRFctalGYVNSSLNPVLYAFLDENFKA 277
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
38-265 3.46e-15

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 74.92  E-value: 3.46e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  38 MACAIF--ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLgFTIMPYSMVRSVE-NCWYFGLTFCKIHYSFDLML 114
Cdd:cd15131   5 VTCVLLfvVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLI-FLCMPLDLYRLWQyRPWNFGDLLCKLFQFVSESC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVP--GAFAFGVVFSEAYADGIEGYDILVACSSSCPVM 192
Cdd:cd15131  84 TYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSflSAGPIFVLVGVEHENGTNPIDTNECKATEYAVR 163
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56605936 193 FNKL----WGTTLFvagFFTPSSMMVGIYGKIFavSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFP 265
Cdd:cd15131 164 SGLLtimvWVSSVF---FFLPVFCLTVLYSLIG--RKLWRRRRENIGPNASHRDKNNRQTVKMLAVVVFAFVLCWLP 235
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
43-314 3.72e-15

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 74.29  E-value: 3.72e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15298  12 LVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWsvpgafafgVVFSEAYADGIEGYDILVA----CSSSCPVMFNKLWG 198
Cdd:cd15298  92 LIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAW---------VLSFVLWAPAILFWQFVVGkrtvPDNQCFIQFLSNPA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 199 TTL--FVAGFFTPSSMMVGIYGKIFAVSKkharvidnlpenqnnqmrKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFL 276
Cdd:cd15298 163 VTFgtAIAAFYLPVVIMTVLYIHISLASA------------------RERKVTRTIFAILLAFILTWTPYNVMVLVNTFC 224
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 56605936 277 NFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15298 225 QSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
40-312 4.09e-15

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 74.74  E-value: 4.09e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIF-ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITS 118
Cdd:cd15195   8 WVLFvISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 119 IFHLCSVAVDRFYAICHPL-HYCTKMTipvVRRLLLVCW------SVPGAFAFGVVfsEAYADGIegydILVACSSSCPV 191
Cdd:cd15195  88 SFMLVVIALDRVFAILSPLsANQARKR---VKIMLTVAWvlsalcSIPQSFIFSVL--RKMPEQP----GFHQCVDFGSA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLWGTTLFV---AGFFTPSSMMVGIYGKI-FAVSKKHARVIDNLPENQ-----NNQMRKDKKAAKTLGIVMGVFLLC 262
Cdd:cd15195 159 PTKKQERLYYFFtmiLSFVIPLIITVTCYLLIlFEISKMAKRARDTPISNRrrsrtNSLERARMRTLRMTALIVLTFIVC 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56605936 263 WFPCFFTIL---LDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15195 239 WGPYYVLGLwywFDKESIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIRN 291
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
40-314 5.75e-15

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 73.81  E-value: 5.75e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFI-TIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLG-FTIMPysmvrsvENCWYFGLTF------CKIHYSFD 111
Cdd:cd15196   8 ATILVlALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlFNVLP-------QLIWDITYRFyggdllCRLVKYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCT------KMTIPVVRRLLLVCwSVPGAFAFGVVfseayADGIEGYDilvac 185
Cdd:cd15196  81 VVGMYASSYVLVATAIDRYIAICHPLSSHRwtsrrvHLMVAIAWVLSLLL-SIPQLFIFSYQ-----EVGSGVYD----- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 186 sssCPVMFNKLWG-----TTLFVAGFFTPSSMMVGIYGKIFavskkhaRVIdnlpenqnnqMRKDKKAAK-TLGIVMgVF 259
Cdd:cd15196 150 ---CWATFEPPWGlrayiTWFTVAVFVVPLIILAFCYGRIC-------YVV----------WRAKIKTVKlTLVVVA-CY 208
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56605936 260 LLCWFPcFFTILL----DPFLNFSTPAVLFDALtwFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15196 209 IVCWTP-FFVVQMwaawDPTAPIEGPAFVIIML--LASLNSCTNPWIYLAFSGNLRRAL 264
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
32-312 9.38e-15

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 73.41  E-value: 9.38e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15401   1 SVLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgafAFGVVFSEAYADGIEGYDILVACSSSCPV 191
Cdd:cd15401  81 GLSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVL----TLAAIVPNFFVGSLQYDPRIYSCTFAQTV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 mfNKLWGTTLFVAGFFTPSSMMVGIYGKIF--AVSKKHARVIDNLPENQNNQMRKdkkaAKTLGIVMGVFLLCWFPCFF- 268
Cdd:cd15401 157 --SSSYTITVVVVHFIVPLSIVTFCYLRIWvlVIQVKHRVRQDSKQKLKANDIRN----FLTMFVVFVLFAVCWGPLNFi 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56605936 269 --TILLDPF-LNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15401 231 glAVAINPLkVAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRK 277
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
44-314 1.03e-14

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 73.34  E-value: 1.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTD--FLLGftiMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFH 121
Cdd:cd15971  13 IGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADelFMLG---LPFLAIQVALVHWPFGKAICRVVMTVDGINQFTSIFC 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHyCTKMTIPVVRRLL-LVCWSVpgafAFGVVFSEAYADGIEGYDILVACSSSCPVMfNKLWGTT 200
Cdd:cd15971  90 LTVMSIDRYLAVVHPIK-SAKWRKPRTAKMInMAVWGV----SLLVILPIMIYAGVQTKHGRSSCTIIWPGE-SSAWYTG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 201 L----FVAGFFTPSSMMVGIY-GKIFAVSKKHARVidnlpeNQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPF 275
Cdd:cd15971 164 FiiytFILGFFVPLTIICLCYlFIIIKVKSSGIRV------GSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVS 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56605936 276 LNFS-TPAV--LFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15971 238 VSISpTPGLkgMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
37-318 1.17e-14

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 72.94  E-value: 1.17e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd15295   6 LMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLLCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFG--VVFSEAYADGiegydilvacSSSCPVMFN 194
Cdd:cd15295  86 ASVYNIVLISYDRYQSVSNAVSYRNQQTATLRIVTQMVAVWVLAFLVHGpaILVSDSWKTE----------DGECEPEFF 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 195 KLWG--TTLFVAGFFTPSSMMVGIYGKIFAVSKKHARvidnlpenqnnqmrkDKKAAKTLGIVMGVFLLCWFP-CFFTIL 271
Cdd:cd15295 156 SNWYilAITSVLEFLVPVILVAYFNTQIYWSLWKRLR---------------DRKLAKSLAIILGTFAICWAPySLFTII 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56605936 272 LDpFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRALKYIL 318
Cdd:cd15295 221 RA-ACEKHRGSPWYNFAFWLQWFNSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
32-314 1.95e-14

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 72.46  E-value: 1.95e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMacaIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHySFD 111
Cdd:cd15397   4 VVSYSLV---MAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMT-PFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSIT-SIFHLCSVAVDRFYAICHPLHYctKMTIPVVRRLLLVCW------SVPgAFAFGVVFSEAYAD---GIEGYDI 181
Cdd:cd15397  80 QCMSVTvSILSLVLIALERHQLIINPTGW--KPSVSQAYLAVVVIWmlacfiSLP-FLAFHILTDEPYKNlshFFAPLAD 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 182 LVACSSSCPVMFNKL-WGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENqNNQMRKDKKAAKTLGIVMGVFL 260
Cdd:cd15397 157 KAVCTESWPSEHHKLaYTTWLLLFQYCLPLLFILVCYLRIYLRLRRRKDMLERRGEY-NRRAGHSKRINVMLVSLVAAFA 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 56605936 261 LCWFPCF-FTILLDPFLNFSTPAV--LFDALTWFGYFNSTC-NPLIYGFFYPWFRRAL 314
Cdd:cd15397 236 LCWLPLNvFNAIADWNHEAIPHCQhnLIFSLCHLAAMASTCvNPIIYGFLNSNFKKEV 293
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
37-313 2.22e-14

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 72.01  E-value: 2.22e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNlAMIISISYFK-QLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15213   6 LMILMIFVGFLGN-SIVCLIVYQKpAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLhycTKMTIPVVRRLLLVCW------SVPGAFAFGVVfsEAYADGIE---GYDILVAcs 186
Cdd:cd15213  85 LEGVAILLIISVDRYLIIVQRQ---DKLNPHRAKILIAVSWvlsfcvSFPPLVGWGKY--EFPPRAPQcvlGYTESPA-- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 187 sscpvmfNKLWGTTLFVAGFFTPSSMMVGIYGKIFavskkharvidnlpenqnNQMRKDK-KAAKTLGIVMGVFLLCWFP 265
Cdd:cd15213 158 -------DRIYVVLLLVAVFFIPFLIMLYSYFCIL------------------NTVRSFKtRAFTTILILFIGFSVCWLP 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56605936 266 CFFTILLDPFLNFSTP-AVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15213 213 YTVYSLLSVFSRYSSSfYVISTCLLWLSYLKSAFNPVIYCWRIKKFREA 261
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
32-312 2.30e-14

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 72.24  E-value: 2.30e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15402   1 TALACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWsvpgAFAFGVVFSEAYADGIEGYDILVACSSSCPV 191
Cdd:cd15402  81 GLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIW----VLTVAAIVPNLFVGSLQYDPRIYSCTFAQSV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 mfNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDnlPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFF--- 268
Cdd:cd15402 157 --SSAYTIAVVFFHFILPIIIVTFCYLRIWILVIQVRRRVK--PDNKPKLKPHDFRNFVTMFVVFVLFAVCWAPLNFigl 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56605936 269 TILLDPFLNFS-TPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15402 233 AVAVDPETIVPrIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRR 277
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
33-311 2.54e-14

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 72.27  E-value: 2.54e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLM-ACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd16003   1 ALWSLAyGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCWSvpgaFAFGVVFSEAYADGIEGYDILVACSSSCPV 191
Cdd:cd16003  81 ITSVFASIYSMTAIAVDRYMAIIDPLK--PRLSATATKVVIGSIWI----LAFLLAFPQCLYSKTKVMPGRTLCFVAWPG 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNK--LWGTTLFVAGFFTPSSMMvGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFP---C 266
Cdd:cd16003 155 GPDQhfTYHIIVIVLVYCLPLLVM-GITYTIVGITLWGGEIPGDTSDKYHEQLRAKRKVVKMMIIVVLTFAICWLPyhiY 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 56605936 267 FFTILLDPFLN-FSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFR 311
Cdd:cd16003 234 FIVTGLYQQLNrWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFR 279
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
29-313 2.64e-14

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 72.04  E-value: 2.64e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  29 GVRAAMYSLmacaIFI-TIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCK-I 106
Cdd:cd15206   1 ELIIPLYSV----IFLlAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKlI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 107 HYSFDLMLSItSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgafAFGV-----VFSEAYADGIEGYDi 181
Cdd:cd15206  77 PYFQAVSVSV-STFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLL----SFLImspilVFSNLIPMSRPGGH- 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 182 lvACSSSCPV-MFNKLWGTTLFVAGFFTPSSMMVGIYGKI---FAVSKKhaRVIdnlpenqnnqmrkdkkaaKTLGIVMG 257
Cdd:cd15206 151 --KCREVWPNeIAEQAWYVFLDLMLLVIPGLVMSVAYGLIswtLLEAKK--RVI------------------RMLFVIVV 208
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56605936 258 VFLLCWFPCFFT---ILLDP---FLNFSTPAVLFDALtwFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15206 209 EFFICWTPLYVIntwKAFDPpsaARYVSSTTISLIQL--LAYISSCVNPITYCFMNKRFRQA 268
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
42-314 2.86e-14

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 72.17  E-value: 2.86e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHySFDLMLSIT-SIF 120
Cdd:cd15396  11 TIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLT-SFVQSVSVSvSIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 121 HLCSVAVDRFYAICHPL-------HYCTKMTIPVVRRLLLvcwSVPgAFAFGVVFSEAYAD---GIEGYDILVACSSSCP 190
Cdd:cd15396  90 SLVLIAIERYQLIVNPRgwkpsasHAYWGIVLIWLFSLMI---SIP-FLIFHQLTDEPFRNlssHSDFYKDKVVCIEAWP 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 VMFNKL-WGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQnNQMRKDKKAAKTLGIVMGVFLLCWFPC-FF 268
Cdd:cd15396 166 SETERLiFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRNSKIDRMRENE-SRLSENKRINTMLISIVVTFAACWLPLnIF 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56605936 269 TILLDPFLN--FSTPAVLFDALTWFGYFNSTC-NPLIYGFFYPWFRRAL 314
Cdd:cd15396 245 NVVFDWNHEvlMSCHHNLVFTLCHLVAMVSTCiNPIFYGFLNKNFQKDL 293
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
44-314 3.50e-14

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 71.74  E-value: 3.50e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWY------FGLTFCKIHYSFDLMLSIT 117
Cdd:cd15350  13 VGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYlnrrgpFETKLDDIMDSLFCLSLLG 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 118 SIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVV-FSEAYADGIegydilvacssscpvmfnkl 196
Cdd:cd15350  93 SIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGGSGILMIlFFHFVATVI-------------------- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 wgttLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFL 276
Cdd:cd15350 153 ----CFTVLFFLMLVLILCLYVHMFLLARSHARKIASLPNHHAQHQRSNMRGAITLTILLGVFVCCWAPFVLHLLLMMFC 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56605936 277 NFSTPAV----LFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15350 229 PMNPYCAcyrsLFQVNGTLIMSHAVIDPAIYAFRSPELRNTF 270
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
41-314 5.62e-14

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 71.26  E-value: 5.62e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  41 AIFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSI 119
Cdd:cd14985   9 AIFLVgLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVISVNMFASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 120 FHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADgIEGYDILVACSSSCPVMFNKLWGT 199
Cdd:cd14985  89 FLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQA-IENLNKTACIMLYPHEAWHFGLSL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 200 TLFVAGFFTPSSMMVGIYGKIFAVSKKHArvidnlpENQNNQMRKDKKAAKTLGIVMGVFLLCWFP-------------- 265
Cdd:cd14985 168 ELNILGFVLPLLIILTCYFHIARSLRKRY-------ERTGKNGRKRRKSLKIIFALVVAFLVCWLPfhffkfldflaqlg 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56605936 266 ----CFFTILLDPFLNFSTPavlfdaltwFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd14985 241 airpCFWELFLDLGLPIATC---------LAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
37-313 6.58e-14

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 70.99  E-value: 6.58e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITifGNLAMIISISYFKQLHTPTNLLILSMAVTD--FLLGftiMPYSMVRSVENCWYFGLTFCKIHYSFDLML 114
Cdd:cd15974   8 LLVCAIGLS--GNTLVIYVVLRYAKMKTVTNIYILNLAVADelFMLG---LPFLATQNAISYWPFGSFLCRLVMTVDGVN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPLHyCTKMTIPVVRRLL-LVCWSVPGAFAFGVVFseaYADGIEGYDilvACSSSCPVMF 193
Cdd:cd15974  83 QFTSIFCLTVMSIDRYLAVVHPIK-STKWRRPRVAKLInATVWTLSFLVVLPVII---FSDVQPDLN---TCNISWPEPV 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 194 NkLWGTTLF----VAGFFTPSSMMVGIYGKI-FAVSKKHARVidnlpeNQNNQMRKDKKAAKTLGIVMGVFLLCWFPcFF 268
Cdd:cd15974 156 S-VWSTAFIiytaVLGFFGPLLVICLCYLLIvIKVKSSGLRV------GSTKRRKSERKVTRMVVIIVVVFVFCWLP-FY 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56605936 269 TILLDPFLNFSTPAVLFDALTWFG----YFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15974 228 MLNIVNLIVILPEEPAFVGVYFFVvvlsYANSCANPILYGFLSDNFKQS 276
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
32-315 6.70e-14

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 71.11  E-value: 6.70e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIhYSFD 111
Cdd:cd15123   1 CAIYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKL-LSFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSI-TSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAF-GVVFSEAYADGIEGYDILVACSSSC 189
Cdd:cd15123  80 QLTSVgVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIpEAVFSDLYSFRDPEKNTTFEACAPY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 190 PV---MFNKLWGTTLFVAGFFTPSSMMVGIYgkiFAVSKKHARVIDNLPENQNNQMRKD----KKAAKTLGIVMGVFLLC 262
Cdd:cd15123 160 PVsekILQEIHSLLCFLVFYIIPLSIISVYY---FLIARTLYKSTFNMPAEEHSHARKQiesrKRVAKTVLVLVALFAFC 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56605936 263 WFPCFFTILLDPFLNFST--PAVLFDALTWF----GYFNSTCNPliygFFYPWFRRALK 315
Cdd:cd15123 237 WLPNHILYLYRSFTYHTSvdSSAFHLIATIFsrvlAFSNSCVNP----FALYWLSKSFR 291
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-275 1.19e-13

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 70.38  E-value: 1.19e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  47 FGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSM----VRSVEncWYFGLTFCKIhYSFDLMLSI-TSIFH 121
Cdd:cd15204  16 VGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMdyyvVRQRS--WTHGDVLCAV-VNYLRTVSLyVSTNA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCW------SVPGAFaFGVVFSEAYADGIegydilvACSSSCPV---M 192
Cdd:cd15204  93 LLVIAIDRYLVIVHPLK--PRMKRRTACVVIALVWvvslllAIPSAV-YSKTTPYANQGKI-------FCGQIWPVdqqA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNKLWGTTLFVAGFFTPSSMMVGIYgkIFAVSKKHARvidNLPENQNNQMRK----DKKAAKTLGIVMGVFLLCWFPCF- 267
Cdd:cd15204 163 YYKAYYLFLFVLEFVLPVLIMTLCY--LRIVRKVWFR---RVPGQQTEQIRRrlrrRRRKVRLLVVILTAFVLCWAPYYg 237

                ....*...
gi 56605936 268 FTILLDPF 275
Cdd:cd15204 238 YAIVRDFF 245
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
37-314 1.58e-13

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 69.83  E-value: 1.58e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIfiTIFGNLAMIISISYFKQLHTPTNLLILSMAVTD--FLLGftiMPYSMVRSVENCWYFGLTFCKIHYSFDLML 114
Cdd:cd15972   8 LVVCVV--GLGGNTLVIYVVLRYSASESVTNIYILNLALADelFMLG---LPFLAAQNALSYWPFGSFMCRLVMTVDAIN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEgydilvACSSSCPVMFN 194
Cdd:cd15972  83 QFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMG------TCHIAWPEPAQ 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 195 kLWGTTLFV----AGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPenqNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTI 270
Cdd:cd15972 157 -VWRAGFIIytatLGFFCPLLVICLCYLLIVVKVRSSGRRVRATS---TKRRGSERKVTRMVVIVVAAFVLCWLPFYALN 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56605936 271 LLDPFLNFSTPAVLFDALTW---FGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15972 233 IVNLVCPLPEEPSLFGLYFFvvvLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
44-305 1.84e-13

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 69.58  E-value: 1.84e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFT----------------IMPYSMVRSVENCwyfgltfckih 107
Cdd:cd15354  13 ISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSnawetitiyllnnrhlVIEDAFVRHIDNV----------- 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 108 ysFDLMLSITSIFHLCS---VAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgAFAFGVVFseayadgiegydilVA 184
Cdd:cd15354  82 --FDSLICISVVASMCSllaIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTF--CTGCGIIF--------------IL 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 185 CSSSCPVMFnklwgttLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWF 264
Cdd:cd15354 144 YSESTYVII-------CLITMFFAMLFLMVSLYIHMFLLARTHVKRIAALPGYNSVRQRTSMKGAVTLTILLGIFIVCWA 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56605936 265 PCFFTILldpfLNFSTPAVLFDA--LTWFGYF------NSTCNPLIYGF 305
Cdd:cd15354 217 PFFLHLI----LMISCPQNLYCVcfMSHFNMYlilimcNSVIDPLIYAF 261
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
42-314 2.39e-13

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 69.38  E-value: 2.39e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIF 120
Cdd:cd15192  10 IFVVgIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSFNLYASVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 121 HLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW------SVPGAFAFGVVFseayadgIEGYDILVacsssCPVMFN 194
Cdd:cd15192  90 LLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWllagvaSLPAIIHRDVFF-------IENTNITV-----CAFHYP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 195 KLWGTTLF-------VAGFFTPSSMMVGIYGKIFAVSKKHARVidnlpenQNNQMRKDkKAAKTLGIVMGVFLLCWFP-- 265
Cdd:cd15192 158 SQNSTLLVglglmknLLGFLIPFLIILTCYTLIGKALKKAYEI-------QRNKPRND-EIFKMIMAVVLFFFFCWIPhq 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56605936 266 --CFFTIL--LDPFLNFSTPAVLFDALTW---FGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15192 230 ifTFLDVLiqLKVIQDCHIADIVDTAMPFticIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
64-314 3.89e-13

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 68.63  E-value: 3.89e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  64 TPTNLLILSMAVTDFLLgFTIMPYSMVRSVE-NCWYFGLTFCKI-HYSFDLMLSITSIFhLCSVAVDRFYAICHPLHYCT 141
Cdd:cd14991  33 KANTVYLFNLVLADFLL-LICLPFRIDYYLRgEHWIFGEAWCRVnLFMLSVNRSASIAF-LTAVALDRYFKVVHPHHRVN 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 142 KMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKlWGTTLFVAGFFTPSSMMVgiygkiF 221
Cdd:cd14991 111 RMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSCHSFSSYTKPSLSIR-WHNALFLLEFFLPLGLIV------F 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 222 AVskkhARVIDNLPENQN-NQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLNFSTP-------AVLFDALTWFGY 293
Cdd:cd14991 184 CS----VRIACNLRIRQSlGKQARVQRAIRLVFLVVIVFVLCFLPSIIAGLLALVFKNLGScrclnsvAQLFHISLAFTY 259
                       250       260
                ....*....|....*....|.
gi 56605936 294 FNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd14991 260 LNSALDPVIYCFSSPWFRNSL 280
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-313 5.28e-13

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 68.29  E-value: 5.28e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDF--LLGFTIMPYSMVRSVEncWYFGLTFCKI-HYSFDLMLSI 116
Cdd:cd15132   9 ILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLliLLCLPFDLYRLWKSRP--WIFGEFLCRLyHYISEGCTYA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TsIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSV------PGAFAFGVvfseAYADGIEGYDILVACSSSCP 190
Cdd:cd15132  87 T-ILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFallsagPFLFLVGV----EQDNNIHPDDFSRECKHTPY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 VMFNKLWGTTLFV--AGFFTPSSMMVGIYGKIFAVSKKHARVIDNlpENQNNQMRKDKKAAKTLGIVMGVFLLCWFPcfF 268
Cdd:cd15132 162 AVSSGLLGIMIWVttTYFFLPMLCLSFLYGFIGRKLWKSKNDLRG--PNAAARERSHRQTVRILAVVVLAFIICWLP--F 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56605936 269 TILLDPFLNFSTPAVLF-------DALTWFgYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15132 238 HIGRILFANTEDYRTMMfsqyfniVAMQLF-YLSASINPILYNLISRKYRAA 288
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-265 5.95e-13

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 68.44  E-value: 5.95e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15125   5 SLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHP---------LHYCTK-MTIPVVRRLLlvcwSVPGAfafgvVFSEAYADGIEGYDILVAC 185
Cdd:cd15125  85 GVSVFTLTALSADRYKAIVNPmdiqtssavLRTCLKaIAIWVVSVLL----AVPEA-----VFSEVAHIMPDDNTTFTAC 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 186 --SSSCPVMFNKLWGTTLFVAGFFTPSSMMVGIYgkiFAVSKKHARVIDNLP----ENQNNQMRKDKKAAKTLGIVMGVF 259
Cdd:cd15125 156 ipYPQTDEMHPKIHSVLIFLVYFLIPLAIISIYY---YHIAKTLIKSAHNIPgeysEHSKRQMETRKRLAKIVLVFVGLF 232

                ....*.
gi 56605936 260 LLCWFP 265
Cdd:cd15125 233 AFCWFP 238
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
33-308 7.78e-13

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 67.87  E-value: 7.78e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIF-ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVE-NCWYFGLTFCKIHYSF 110
Cdd:cd15212   1 AAQALVLLAIFlLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSrPGWLFGDRLCLANGFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 111 DLMLSITSIFHLCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCWSVPGAFAFG--VVFSEAYADGIEGYDILVACSSS 188
Cdd:cd15212  81 NACFGIVSTLTMTLISFDRYYAIVRQPQ--GKIGRRRALQLLAAAWLTALGFSLPwyLLASAPEYYEKLGFYHCLYVLHS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 189 CPVMFNKLWGTTLFVAGFFTPSSMMVGIYGKIF-AVSKKHARVidnLPENQ-------NNQMRkdkkAAKTLGIVMGVFL 260
Cdd:cd15212 159 GPSRLGAAYSSVLIVLCYLLPFALMCFCHYNICkTVRLSESRV---RPVTTyahllrfYSEMR----TATTVLIMIVFII 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56605936 261 LCWFPCFFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYP 308
Cdd:cd15212 232 CCWGPYCLLGLVAAAGGYQFPPLMDTVAIWMAWANGAINPLIYAIRNP 279
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
44-314 1.19e-12

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 67.27  E-value: 1.19e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYF-KQLHTPTNLLILSMAVTDFLLGFtimpYSMVRSVENCWYFGL-----------TFCKIHYSFD 111
Cdd:cd14980  13 LALIGNILVIIWHISSkKKKKKVPKLLIINLAIADFLMGI----YLLIIAIADQYYRGRyaqyseewlrsPPCLLACFLV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHyCTKMTIPVVRRLLLVCWSVPGAFAFG-VVFSEAYAdgieGYDILVACSSSC- 189
Cdd:cd14980  89 SLSSLMSVLMMLLITLDRYICIVYPFS-NKRLSYKSAKIILILGWLFSIIFAAIpILYSINQP----GDNRLYGYSSICm 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 190 PVMFN----KLWGTTLFVAGFFTpSSMMVGIYGKIFAVSKKHARvidnlpENQNNQMRKDKKAAKTLGIVMGVFLLCWFP 265
Cdd:cd14980 164 PSNVSnpyyRGWLIAYLLLTFIA-WIIICILYILIFISVRKSRK------SARRSSSKRDKRIAIRLALILITDLICWLP 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56605936 266 cFFTILLDPFLNFSTpaVLFDALTWFGYF----NSTCNPLIYGFFYPWFRRAL 314
Cdd:cd14980 237 -YYIVIFSGLLTSTE--IDIHVLQFIAILalplNSAINPYLYTLTTPTFKRDF 286
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
44-305 1.73e-12

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 66.47  E-value: 1.73e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENcwyFGLT-----FCKIHYSFDLMLS--- 115
Cdd:cd15353  13 VSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLN---GNDTdaqsfTVNIDNVIDSVICssl 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSvpgafafgvvfseayADGIEGYDILVACSSSCPVMfnk 195
Cdd:cd15353  90 LASICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWT---------------ACTVSGVLFIIYSDSSVVII--- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 196 lwgttLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPF 275
Cdd:cd15353 152 -----CLISMFFTMLALMASLYVHMFLLARLHIKRIAVLPGTGPIRQGANMKGAITLTILLGVFVVCWAPFFLHLIFYIS 226
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 56605936 276 LNFSTPAVLFdaLTWFGYF------NSTCNPLIYGF 305
Cdd:cd15353 227 CPRNPYCVCF--MSHFNMYlilimcNSVIDPLIYAF 260
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
37-314 2.21e-12

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 66.39  E-value: 2.21e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd15078   6 LIATIGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFGI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICHplhyCTKMTIPVVRRLLLVCWSVPGAFA-FGVVFSEAYADGIEGYDILVACSSSCP----- 190
Cdd:cd15078  86 VSIMTLTVLAYERYIRVVH----AKVVNFSWSWRAITYIWLYSLAWTgAPLLGWNRYTLEVHGLGCSFDWKSKDPndtsf 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 VMFnklwgttLFVAGFFTPSSMMVGIYGKIFAVSKKhARVIDNLPENQNNQ-MRKDKKAAKTLGIVMGVFLLCWFPCFFT 269
Cdd:cd15078 162 VLL-------FFLGCLVVPLGIMAYCYGHILYEIRM-LRSVEDLQTFQVIKiLKYEKKVAKMCLLMISTFLICWMPYAVV 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56605936 270 ILLDPF--LNFSTPAVLFDAlTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15078 234 SLLVTSgySKLVTPTIAIIP-SLFAKSSTAYNPVIYIFMIRKFRQCL 279
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
32-303 2.65e-12

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 66.43  E-value: 2.65e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMacaIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd16002   4 AVAYSVI---VVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCWSvpgaFAFGVVFSEAYADGIEGYDILVACSSSCPV 191
Cdd:cd16002  81 IAAVFASIYSMTAIALDRYMAIIHPLQ--PRLSATATKVVICVIWV----LAFLLAFPQGYYSDTEEMPGRVVCYVEWPE 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLWGTT----LFVAGFFTPSSMMVGIYgKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCF 267
Cdd:cd16002 155 HEERKYETVyhvcVTVLIYFLPLLVIGCAY-TVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPYH 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 56605936 268 FTILLDPF----LNFSTPAVLFDALTWFGYFNSTCNPLIY 303
Cdd:cd16002 234 IYFLLQYFhpelYEQKFIQQVYLAIMWLAMSSTMYNPIIY 273
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
33-312 3.12e-12

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 65.95  E-value: 3.12e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHySFDL 112
Cdd:cd15209   2 ALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQAS-GFIM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLS-ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAfafgVVFSEAYADGIEGYDILVACSSSCPV 191
Cdd:cd15209  81 GLSvIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVL----AVLPNFFIGSLQYDPRIYSCTFAQTV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 mfNKLWGTTLFVAGFFTPSSMMVGIYGKIF--AVSKKHARVIDNLPENQNNQMRKdkkaAKTLGIVMGVFLLCWFPCFFT 269
Cdd:cd15209 157 --STVYTITVVVIHFLLPLLIVSFCYLRIWvlVLQVRQRVKPDQRPKLKPADVRN----FLTMFVVFVLFAVCWAPLNFI 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56605936 270 ILL---DPF-LNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15209 231 GLAvaiNPKeMAPKIPEWLFVASYFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
30-312 3.38e-12

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 65.64  E-value: 3.38e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  30 VRAAMYSLMACAifiTIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYS 109
Cdd:cd15215   1 IRSVLIVIFLCA---SLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVV 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 110 FDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW------SVPGAFAFGVV-FSEAyadgiegydil 182
Cdd:cd15215  78 LMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWivsvlqSTPPLYGWGQAaFDER----------- 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 183 vacSSSCPVMFNKLWGTTLFVAGFF--TPSSMMVGIYGKIFAVSKKHARVidnlpenqnnqmrkdkKAAKTLGIVMGVFL 260
Cdd:cd15215 147 ---NALCSVIWGSSYSYTILSVVSSfvLPVIIMLACYSMVFRAARRCYHC----------------KAAKVIFIIIFSYV 207
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56605936 261 LCWFPCFFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15215 208 LSMGPYSFLSVLAVWVDTQVPQWVISIILWLFFLQCCIHPYIYGYMHKSIKK 259
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
44-167 5.13e-12

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 65.32  E-value: 5.13e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15431  13 VTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECLLLA 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSvpGAFAFGVV 167
Cdd:cd15431  93 VMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWV--SAFLLTVI 134
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
44-272 6.61e-12

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 64.77  E-value: 6.61e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENcwyFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15905  11 LIIFANLFIILGIACNRKLHNTANYFFLSLLLADLLTGVALPFIPGMSNESR---RGYHSCLFVYVAPNFLFLSFLANLL 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseayadGIEGYDILVACSSScpVMFNKLWgTTLFV 203
Cdd:cd15905  88 MVHYERYLCIVYPLQYHNFWVHRWVPLALLLTWALPLLFACLPAL------GWNNWTPGSNCSYK--QVFPAAY-IYLEV 158
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56605936 204 AGFFTPSSM-MVGIYGKIFAVSKKHARVIDNL--------PENQNNQMrkDKKAAKTLGIVMGVFLLCWFPCFFTILL 272
Cdd:cd15905 159 YGLVLPSILaIAFMSVRVLAVARRQLQDICKLlravqrdgPSELEQQL--NLRYAKCIAGVSLTFLVCWVPYIAYLLM 234
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
42-314 7.70e-12

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 64.98  E-value: 7.70e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYF---KQLHTPTNLLILSMAVTDFLLGFTI---MPYSMVRsveNCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd14982   8 SLIFILGLLGNILALWVFlrkMKKRSPTTIYMINLALADLLFVLTLpfrIYYYLNG---GWWPFGDFLCRLTGLLFYINM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDIlvaCSSSCPVMFNK 195
Cdd:cd14982  85 YGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTT---CFEFLSEWLAS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 196 L--WGTTLFVAGFFTPSSMMVGIYGKIFAVskkharVIDNLPENQNNQMRkdKKAAKTLGIVMGVFLLCW------FPCF 267
Cdd:cd14982 162 AapIVLIALVVGFLIPLLIILVCYSLIIRA------LRRRSKQSQKSVRK--RKALRMILIVLAVFLVCFlpyhvtRILY 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 268 FTILLDPFLNFSTPAVLFDAL---TWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd14982 234 LLVRLSFIADCSARNSLYKAYritLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
33-265 8.38e-12

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 64.92  E-value: 8.38e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15124   2 AIPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAF-GVVFSEAYADGIEGYDILVACSSSCP- 190
Cdd:cd15124  82 TSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIpEAVFSDLHPFYDKSTNKTFVSCAPYPh 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 --VMFNKLWGTTLFVAGFFTPSSMMVGIYgkiFAVSKKHARVIDNLPENQNNQMRKD----KKAAKTLGIVMGVFLLCWF 264
Cdd:cd15124 162 snELHPKIHSMASFLIFYVIPLSIISVYY---YFIAKNLIRSAYNLPVEGNVHVRRQiesrKRLAKTVLVFVGLFAFCWL 238

                .
gi 56605936 265 P 265
Cdd:cd15124 239 P 239
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
33-314 1.01e-11

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 64.64  E-value: 1.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFItifGNLAMIISIsYFKQLHTP--TNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSF 110
Cdd:cd15382   5 IVYSVLFLIAAV---GNLTVLLIL-LRNRRRKRsrVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 111 DLMLSITSIFHLCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCW------SVPGAFAFGVVfSEAYADGIEGYDILVA 184
Cdd:cd15382  81 RAFGLYLSSFVLVCISLDRYFAILKPLR--LSDARRRGRIMLAVAWvisflcSIPQSFIFHVE-SHPCVTWFSQCVTFNF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 185 CSSSCPVMFNKLWGTTLFvagFFTPSSMMVGIYGKIFA-VSKKHARVIDNLPE----------NQNNQMRKDKKAAK-TL 252
Cdd:cd15382 158 FPSHDHELAYNIFNMITM---YALPLIIIVFCYSLILCeISRKSKEKKEDVSEksssvrlrrsSVGLLERARSRTLKmTI 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56605936 253 GIVMgVFLLCWFPcFFTILLDPFLNFST----PAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15382 235 VIVL-VFIICWTP-YFIMSLWYWFDRESaskvDPRIQKGLFLFAVSNSCMNPIVYGYFSIDLRREL 298
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
49-314 1.03e-11

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 64.42  E-value: 1.03e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  49 NLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLtfckIHYSFDLMLSITSIFHLCSVAVD 128
Cdd:cd15100  18 NAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGLGLILHFVFRYCVYSEALSL----VSVGLLVAAFSASVCSLLAITVD 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 129 RFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseayadGIEGYDILVACSSSCPVMFNKLwgtTLFVAGFFT 208
Cdd:cd15100  94 RYLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLPVL------GWNCLREGSSCSVVRPLTKNHL---AVLAVAFLL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 209 PSSMMVGIYGKIFAVSKKHARVI----DNLPENQNNQMRkdkKAAKTLGIVMGVFLLCWFPCFFTILLDpflNFSTPAVL 284
Cdd:cd15100 165 VFALMLQLYAQICRIVLRHAHQIalqrHFLAPSHYVATR---KGVSTLALILGTFAACWIPFAVYCLLG---DGSSPALY 238
                       250       260       270
                ....*....|....*....|....*....|
gi 56605936 285 FDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15100 239 TYATLLPATYNSMINPIIYAFRNQDIQKVL 268
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
44-314 1.40e-11

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 64.04  E-value: 1.40e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHY---SFDLMLS---IT 117
Cdd:cd15351  13 VSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHmdnVIDTMICssvVS 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 118 SIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPgafafgvvfseayadgiegydilVACSSSCPVMFNKLW 197
Cdd:cd15351  93 SLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLAS-----------------------TVSSTLFIVYYNSNA 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 198 GTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDK-KAAKTLGIVMGVFLLCWFPCFFTILL---- 272
Cdd:cd15351 150 VILCLIVFFLFMLVLMLVLYIHMFILACRHSQSISSQQRRQCPHQQTASlKGAITLTILLGIFFLCWGPFFLHLTLivtc 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56605936 273 --DPF-LNFSTPAVLFDALTwfgYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15351 230 ptHPFcLCYFKYFNLFLILI---ICNSIIDPLIYAFRSQELRKTL 271
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
40-314 1.41e-11

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 64.22  E-value: 1.41e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFITIF-----GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTImPYSMVrSVENCWYFGLTFCKIHYSFDLML 114
Cdd:cd15178   4 CVIYVLVFllslpGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTL-PFWAV-SVVKGWIFGTFMCKLVSLLQEAN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPL------HYCTKMTIPVVRRLLLVcWSVPGAFaFGVVFSEAYADGIEGYDILVACSSS 188
Cdd:cd15178  82 FYSGILLLACISVDRYLAIVHATraltqkRHLVKFVCAGVWLLSLL-LSLPALL-NRDAFKPPNSGRTVCYENLGNESAD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 189 CPVMFNKLWGTTLfvaGFFTPSSMMVGIYGkIFAVSKKHARvidnlpenqnnqMRKDKKAAKTLGIVMGVFLLCWFPCFF 268
Cdd:cd15178 160 KWRVVLRILRHTL---GFLLPLVVMLFCYG-FTIKTLLQTR------------SFQKHRAMRVIFAVVLAFLLCWLPYNV 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56605936 269 TILLDPFL-----NFSTPA-----VLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15178 224 TVLIDTLMrtkliTETCELrnhvdVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
34-314 1.50e-11

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 64.06  E-value: 1.50e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAIFITIFGNLAMIISISYFKQLH---TPTNLLILSMAVTD--FLLGftiMPYSMVRSVEN-CWYFGLTFCKIH 107
Cdd:cd15338   3 MPSVFGVICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDllFLLG---MPFLIHQLLGNgVWHFGETMCTLI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 108 YSFDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPgafAFGVVFSEAYADGIEGYDILVACSS 187
Cdd:cd15338  80 TALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILS---LLSITPVWMYAGLMPLPDGSVGCAL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 188 SCPVMFNKLWGTTL--FVAGFFTPSSMMVGIYGKIFavsKKHARVIDNLPenQNNQMRKDKKAAKTLGIVMGVFLLCWFP 265
Cdd:cd15338 157 LLPNPETDTYWFTLyqFFLAFALPLVVICVVYFKIL---QNMASTVAPLP--QRSLRVRTKKVTRMAVAICLAFFICWAP 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56605936 266 cfFTILLDPFLNFSTPAVLF----DALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15338 232 --FYILQLAHLSIDRPSLAFlyayNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
44-306 1.54e-11

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 63.98  E-value: 1.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLG-FTIMPySMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15197  13 FIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGlINVLT-DIIWRITVEWRAGDFACKVIRYLQVVVTYASTYVL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMtipvVRRLLLVC--WSVpgAFAFGVVFSEAYADGIEGYDiLVACSSSCPVMFN-KLWGT 199
Cdd:cd15197  92 VALSIDRYDAICHPMNFSQSG----RQARVLICvaWIL--SALFSIPMLIIFEKTGLSNG-EVQCWILWPEPWYwKVYMT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 200 TLFVAGFFTPSSMMVGIYG----KIFAVSKKHARVIDNLPENQNNQM--------RKDKKAAKTLGIVMGVFLLCWFPCF 267
Cdd:cd15197 165 IVAFLVFFIPATIISICYIiivrTIWKKSKIQVTINKAGLHDGSSRRsssrgiipRAKIKTIKMTFVIVTVFIICWSPYF 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56605936 268 FTILLDPFLNFSTPAVLFDALTW---FGYFNSTCNPLIYGFF 306
Cdd:cd15197 245 VFDLLDVFGLLPRSKTKIAAATFiqsLAPLNSAINPLIYCLF 286
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
35-156 2.10e-11

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 63.40  E-value: 2.10e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  35 YSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPysmvRSVENCWYFGLTfckIHYS----- 109
Cdd:cd15918   4 FGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVP----KMLVNIQTQSKS---ISYAgcltq 76
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 56605936 110 --FDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15918  77 myFFLLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASW 125
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
33-314 3.46e-11

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 62.79  E-value: 3.46e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLmacAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENcWYFGLTFCKIHYSFDL 112
Cdd:cd15180   5 VLYSL---VFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVT-LPFWAVQAVHG-WIFGTGLCKLAGAVFK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW------SVPGaFAFGVVFSEAYADGIEgydilvaCS 186
Cdd:cd15180  80 INFYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWlfclllSIPD-FIFLEATKDPRQNKTE-------CV 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 187 SSCPvMFNKLWGTTL----FVAGFFTPSSMMVGIYGKIFAVSKkharvidnlpenQNNQMRKDKKAAKTLGIVMGVFLLC 262
Cdd:cd15180 152 HNFP-QSDTYWWLALrllyHIVGFLLPLAVMVYCYTSILLRLL------------RSSQGFQKQRAIRVIVAVVVVFFLC 218
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56605936 263 WFPCFFTILLDPFLNFSTPA----------VLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15180 219 WTPYNIALLVDTLIDLSVLDrncgtesrldIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
36-314 4.48e-11

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 62.57  E-value: 4.48e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFL---LGFTIMPYSMVRSVEncWYFGLTFCKIHYSFD 111
Cdd:cd15357   4 SLVYAVIFVVgVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLvllFGMPLEVYEMWSNYP--FLFGPVGCYFKTALF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW------SVPGAFAFGVVFSeAYADGiegydILVAC 185
Cdd:cd15357  82 ETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWvlsvlfSIPNTSIHGIKLQ-YFPNG-----TLIPD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 186 SSSCPV-----MFNKLWGTTLFVagFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFL 260
Cdd:cd15357 156 SATCTVvkplwIYNLIIQITSLL--FYVLPMGVISVLYYLMGLKLRGDKSLEADEMNVNIQRPSRKSVTKMLFVLVLVFA 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 261 LCWFP-----CFFTILLDPFLNFSTPAVLFDALTW-FGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15357 234 ICWAPfhvdrLFFSFVVEWTEPLANVFNLIHVVSGvFFYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
44-154 4.54e-11

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 62.42  E-value: 4.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15412  13 ITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYYMLA 92
                        90       100       110
                ....*....|....*....|....*....|.
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLV 154
Cdd:cd15412  93 VMAYDRYMAICNPLLYSVKMSRRVCISLVTF 123
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
44-313 5.60e-11

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 62.02  E-value: 5.60e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGF-TIMPY-SMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFH 121
Cdd:cd14995  13 VGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVaAGLPNeIESLLGPDSWIYGYAGCLLITYLQYLGINASSLS 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKLWGTTL 201
Cdd:cd14995  93 ITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIKHYGDDIVVRCGYKVSRHYYLPIYLAD 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 202 FVAGFFTPSSMMVGIYGKIfavskkhARVIdnlpenqnnqMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLN--FS 279
Cdd:cd14995 173 FVLFYVIPLLLAIVLYGLI-------GRIL----------FSSRKQVTKMLAVVVVLFALLWMPYRTLVVYNSFASppYL 235
                       250       260       270
                ....*....|....*....|....*....|....
gi 56605936 280 TPAVLFDALTWFgYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd14995 236 DLWFLLFCRTCI-YLNSAINPILYNLMSQKFRAA 268
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
42-305 5.65e-11

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 62.09  E-value: 5.65e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENcWYFGLTFCK-IHYSFDLMLSiTSI 119
Cdd:cd15179  10 IFLLgIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLT-LPFWAVDAAAN-WYFGNFLCKaVHVIYTVNLY-SSV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 120 FHLCSVAVDRFYAICHplhyCTKMTIPvvRRLL---LVCWSVPGAFAFGVVFSEAYADgIEGYDILVACSSSCPVMFNKL 196
Cdd:cd15179  87 LILAFISLDRYLAIVH----ATNSQRP--RKLLaekVVYVGVWLPALLLTVPDLVFAK-VSELDDRYICDRIYPEDTFEL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGTTL----FVAGFFTPSSMMVGIYGKIfavskkharvIDNLPENQNNQMRkdkKAAKTLGIVMGVFLLCWFPCFFTILL 272
Cdd:cd15179 160 WVVAFrfqhILVGLVLPGLVILTCYCII----------ISKLSHSKGHQKR---KALKTTVILILAFFACWLPYYIGISI 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 56605936 273 DPFLNF----------STPAVLFDALTWFGYFNSTCNPLIYGF 305
Cdd:cd15179 227 DTFMLLeiikqscemeQTVHKWISITEALAFFHCCLNPILYAF 269
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
43-156 5.73e-11

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 62.14  E-value: 5.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15230  12 LITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFLL 91
                        90       100       110
                ....*....|....*....|....*....|....
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15230  92 AAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSY 125
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
32-312 5.74e-11

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 62.18  E-value: 5.74e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHySFD 111
Cdd:cd15400   1 TALSSVLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVS-GFV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLS-ITSIFHLCSVAVDRFYAICHPLHY-------CTKMTIPVVrRLLLVCWSVPGAFafgvVFSEAYADGIEGYDILV 183
Cdd:cd15400  80 MGLSvIGSIFNITGIAINRYCYICHSFAYdklysrwNTLLYVCLI-WALTVVAIVPNFF----VGSLEYDPRIYSCTFVQ 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 184 ACSSScpvmfnklWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDnlPENQNNQMRKDKKAAKTLGIVMGVFLLCW 263
Cdd:cd15400 155 TASSS--------YTIAVVVIHFIVPITVVSFCYLRIWVLVIQVRRKVK--SESKPRLKPSDFRNFLTMFVVFVIFAICW 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56605936 264 FPCFF---TILLDP-FLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15400 225 APLNLiglAVAINPqEMAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
37-314 6.32e-11

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 62.44  E-value: 6.32e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIF-ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd14977   5 SLSLVIFaVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVTSL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCtkmTIPVVRRL---LLVCWS------VPGAFAFGVVFSEAYADGIegYDILVACS 186
Cdd:cd14977  85 GVTVFSLCALSIDRYRAAVNSMPMQ---TIGACLSTcvkLAVIWVgsvllaVPEAVLSTVARESSLDNSS--LTVCIMKP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 187 SSCPVMFNKLWGTTLFVAGFFTPSSMMVGIYgkIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPC 266
Cdd:cd14977 160 STPFAETYPKARSWWLFGCYFCLPLAFTAVC--YLLMARTLIRAAKEYTRGTKKHMKQRRQLAKTVLCLVLVFAFCWLPE 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56605936 267 FFTILLDPFLNFSTPAVLFDALTWFGY-------FNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd14977 238 HISNILRATLYNEVLIDTRSTLDILDLigqflsfFNSCVNPIALYLLSEPFRRAF 292
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
30-314 7.17e-11

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 61.81  E-value: 7.17e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  30 VRAAMYSLMacaIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYS 109
Cdd:cd15978   2 VRILLYSLI---FLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 110 FDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWsvpgAFAFGVVFS-EAYADGIEGYDILVACSSS 188
Cdd:cd15978  79 FMGISVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATW----CLSFTIMLPyPIYSNLVPFTRINNSTGNM 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 189 CPVMF-----NKLWGTTLFVAGFFTPSSMMVGIYGKIfavSKKHARVIDNLpenqnnqMRKdKKAAKTLGIVMGVFLLCW 263
Cdd:cd15978 155 CRLLWpndvtQQSWYIFLLLILFLIPGIVMMTAYGLI---SLELYRGIKFL-------MAK-KRVIRMLIVIVILFFLCW 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56605936 264 FPCFFTILLDPFLNFSTPAVLFDALTWF----GYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15978 224 TPIFSANAWRAFDTRSADRLLSGAPISFihllSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
32-313 7.18e-11

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 62.17  E-value: 7.18e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFglTFCKIHYSFD 111
Cdd:cd15071   1 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEF--YSCLMVACPV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgAFAFGVV----------FSEAYADGIEGYDI 181
Cdd:cd15071  79 LILTQSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWIL--SFLVGLTpmfgwnnlnaVERAWAANSSMGEL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 182 LVAC------SSSCPVMFNklwgttlFVAGFFTPSSMMVGIYGKIF-AVSKKHARVIDNLPENQNNQMRKDKKAAKTLGI 254
Cdd:cd15071 157 VIKCqfetviSMEYMVYFN-------FFVWVLPPLLLMLLIYLEVFyLIRKQLNKKVSSSSSDPQKYYGKELKIAKSLAL 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 255 VMGVFLLCWFPCFFTILLDPFL-NFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15071 230 ILFLFALSWLPLHILNCITLFCpSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTT 289
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
44-158 7.88e-11

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 61.95  E-value: 7.88e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15411  13 ITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFLLG 92
                        90       100       110
                ....*....|....*....|....*....|....*
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSV 158
Cdd:cd15411  93 LMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAA 127
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
63-312 8.19e-11

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 61.77  E-value: 8.19e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  63 HTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRFYAICHPLHYCTK 142
Cdd:cd15097  33 HNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTMYASSFTLAAVSVDRYLAIRYPLRSREL 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 143 MTIPVVRRLLLVCWSVPGAFAfGVVFSeaYADGIEgYDILVACSSSCPVMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFa 222
Cdd:cd15097 113 RTPRNAVAAIALIWGLSLLFA-GPYLS--YYDLID-YANSTVCMPGWEEARRKAMDTCTFAFGYLIPVLVVSLSYTRTI- 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 223 vsKKHARVIDNLpENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPF--LNFSTPAVLFDALT-WFGYFNSTCN 299
Cdd:cd15097 188 --KYLWTAVDPL-EAMSESKRAKRKVTKMIIIVTALFCLCWLPHHVVILCYLYgdFPFNQATYAFRLLShCMAYANSCLN 264
                       250
                ....*....|...
gi 56605936 300 PLIYGFFYPWFRR 312
Cdd:cd15097 265 PIVYALVSKHFRK 277
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
47-314 1.03e-10

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 61.45  E-value: 1.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  47 FGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTfckihySFDLMLSI--TSIFHLCS 124
Cdd:cd15960  16 CENAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGLIANFVAIYVMNSEAVTLC------SAGLLLAAfsASVCSLLA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 125 VAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgAFAFGVVfseaYADGIEGYDILVACSSSCPVMFNKLWGTTLfva 204
Cdd:cd15960  90 ITVDRYLSLYNALTYHTERTLTFTYGLLALLWLT--CIGIGLL----PAMGWNCLRAPASCSVLRPVTKNNAAVLAV--- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 205 GFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQM-RKDKKAAKTLGIVMGVFLLCWFP-CFFTILLDPflnfSTPA 282
Cdd:cd15960 161 SFLLLFALMMQLYLQICRIAFRHAQQIAVQHQFVNFCLaSSTRKGVSTLSLILATFAFCWVPfAVYSMVADS----SYPM 236
                       250       260       270
                ....*....|....*....|....*....|..
gi 56605936 283 VLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15960 237 IYTYYLVLPAACNSVINPIIYAFRNPDIQKSL 268
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
35-314 1.03e-10

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 61.49  E-value: 1.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  35 YSLMACAIFITIFGNLAMIIS-ISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLtfckIHYSFDLM 113
Cdd:cd15962   3 WDIMLCISGTVIACENAIVVAiIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETISL----ITVGFLVA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseayadGIEGYDILVACSSSCPVMF 193
Cdd:cd15962  79 SFTASVSSLLAITVDRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGLLPVL------GWNCLEERASCSIVRPLTK 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 194 NKLwgtTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIdNLPEN--QNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTIL 271
Cdd:cd15962 153 SNV---TLLSASFFFIFILMLHLYIKICKIVCRHAHQI-ALQQHflTASHYVATKKGVSTLAIILGTFGASWLPFAIYCV 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 56605936 272 LDpflNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15962 229 VG---DHEYPAVYTYATLLPATYNSMINPIIYAYRNQEIQRSM 268
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
44-305 1.13e-10

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 61.44  E-value: 1.13e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLT--FC-KIHYSFDLMLSIT--- 117
Cdd:cd15352  13 VSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISdqFIqHMDNVFDSMICISlva 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 118 SIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFafGVVFseayadgiegydilVACSSSCPVMfnklw 197
Cdd:cd15352  93 SICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVC--GIVF--------------IVYSESKTVI----- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 198 gtTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNN--QMRKDKKAAKTLGIVMGVFLLCWFPCFFTILL--- 272
Cdd:cd15352 152 --VCLITMFFAMLVLMATLYVHMFLFARLHVKRIAALPPAVDGapQQRSCMKGAVTITILLGVFIVCWAPFFLHLILiis 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 56605936 273 ---DPFL-----NFSTPAVLFdaltwfgYFNSTCNPLIYGF 305
Cdd:cd15352 230 cphNPYClcytsHFNTYLVLI-------MCNSVIDPLIYAF 263
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
44-166 1.15e-10

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 61.18  E-value: 1.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15413  13 TTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELFLLS 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTipvvRRLLLVCWSVPGAFAFGV 166
Cdd:cd15413  93 AMAYDRYVAICNPLLYTVIMS----QRVCIVLVAIPYLYSFFV 131
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
40-313 1.75e-10

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 61.01  E-value: 1.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFITIF-----GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENC-WYFGLTFCKIHYSFDLM 113
Cdd:cd15133   4 CLTYLLIFvvgvvGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNYpFLLGSGGCYFKTFLFET 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWsvpgafAFGVVFSEAYAD--GIEGYDILVACSSSCPV 191
Cdd:cd15133  84 VCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVW------GVSMLCALPNTSlhGIKFLGSGVPASAQCTV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 -----MFNKLWGTTLFVAGFFTPSSMMVGIY--GKIFAVSKKH-----ARVIDNLPENQNNQMRKDKKAAKTLGIVMGVF 259
Cdd:cd15133 158 rkpqaIYNMIPQHTGHLFFVLPMAVISVLYLlmALRLARERGLdatgaGSKIGTRTGQLLQHPRTRAQVTKMLFILVVVF 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 260 LLCWFPCFFTILLDPFLNFSTP--AVLFDAL----TWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15133 238 AICWAPFHIDRLMWSFISDWTDnlHEVFQYVhiisGVFFYLSSAVNPILYNLMSTRFREM 297
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
33-311 1.80e-10

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 60.95  E-value: 1.80e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAI-FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFglTFCKIHYSFD 111
Cdd:cd15070   1 VTYISIEILIgLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGVTIHF--YSCLFMSCLL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgAFAFGVVFSEAYADGIEGYDIlvaCSSSCPV 191
Cdd:cd15070  79 VVFTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLV--SFLVGLTPMFGWNRKPSLESV---NTTPLQC 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLWGTTLFVA-GFFT----PSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFP- 265
Cdd:cd15070 154 QFTSVMRMDYMVYfSFFTwiliPLVIMCALYVDIFYIIRNKLSQNATGFRETGAFYGREFKTAKSLALVLFLFAVCWLPl 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 56605936 266 CFFTILLdpFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFR 311
Cdd:cd15070 234 SIINCVV--YFNPKVPKIALYLGILLSHANSMMNPIVYACKIKKFK 277
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
42-313 2.47e-10

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 60.60  E-value: 2.47e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCK-IHYSFDLMLSItSIF 120
Cdd:cd15399  11 ILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHlVPYAQALAVHV-STV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 121 HLCSVAVDRFYAICHplHYCTKMTIPVVRRLLLVCWSVPGAFAFGV-VFSEAYADGIEGYDILVACSSSCP---VMFNKL 196
Cdd:cd15399  90 TLTVIALDRHRCIVY--HLESKISKKISFLIIGLTWAASALLASPLaIFREYSVIEISPDFKIQACSEKWPngtLNDGTI 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARvidnlPENQNNQ-MRKDKKAAKTLGIVMGVFLLCWFPC-FFTILLD- 273
Cdd:cd15399 168 YSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVS-----PGGGNDHyHQRRRKTTKMLVCVVVVFAVSWLPFhAFQLASDi 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56605936 274 --PFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15399 243 dsKVLDLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTA 284
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
33-314 2.61e-10

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 60.22  E-value: 2.61e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFItiFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPySMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15348   4 AVAFLAVCAFIV--LENLIVLLALWRNKKFHSPMFYLLGSLTLSDLLAGAAYAA-NILMSGANTLKLTPALWFLREGGVF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTipvVRRLLLVcwsvPGAFAFGVVFSEAYADGIEGYDILVACSSSCPvM 192
Cdd:cd15348  81 ITLTASVFSLLAIAIERHITMVRMKPYPGDKR---GRMFLLI----GAAWLVSILLGVLPILGWNCLGNLDACSTVLP-L 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNKLWgtTLFVAGFFTPSSM-MVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAA--KTLGIVMGVFLLCWFPCFFT 269
Cdd:cd15348 153 YAKSY--ILFCITVFLAILAaIVVLYARIYRIVKANSQRLGALPTRKGRARRSQKYLAllKTVTIVLGTFVACWLPLFLL 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56605936 270 ILLDPFLNFSTPAVLFDALTWFG--YFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15348 231 LLLDVSCPAQACPVLLKADYFLGlaMINSLLNPIIYTLTSRDMRRAI 277
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
35-265 4.91e-10

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 59.59  E-value: 4.91e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  35 YSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHySFDLML 114
Cdd:cd15927   4 PILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLS-EFLKDT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SI-TSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAF-GVVFSEAYADGIEGYDILVACSS---SC 189
Cdd:cd15927  83 SIgVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIpEAIFSHVVTFTLTDNQTIQICYPypqEL 162
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56605936 190 PVMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNL-PENQNNQMRKDKKAAKTLGIVMGVFLLCWFP 265
Cdd:cd15927 163 GPNYPKIMVLLRFLVYYLIPLLIIGVFYVLMARHLIRSTRNIGSGqNQAAQRQIEARKKVAKTVLAFVVLFAVCWLP 239
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
32-312 5.15e-10

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 59.40  E-value: 5.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGN-LAMIISISYfKQLHTPTNLLILSMAVTDFLLgFTIMPYSMVRSVEN-CWYFGLTFCKIHYS 109
Cdd:cd15200   1 AFLAPVLGIEFVLGLVGNgIALFIFCFH-RRPWKSNTMYLLSLVVADFFL-IINLPFRIDYYLRNeVWRFGATACQVNLF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 110 FDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADG--IEGYDILVACSS 187
Cdd:cd15200  79 MLSMNRTASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHLLLLDHVQSNstCLSYDHGTDPSA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 188 ScpvmfnKLWGTTLFVAGFFTPSSMMvgiygkIFAVskkhARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCF 267
Cdd:cd15200 159 S------DRWHRILFFLEFFLPLGII------LFCI----FSIILTLKQRKLAKQAGPQRAVKVLAVIVLVYTVCFLPSI 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56605936 268 F-------TILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15200 223 LfalaslvAFKVSQCRSLDLCTQLFHGSLAFTYLNSALDPVLYCFSSPSFLN 274
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
37-313 6.27e-10

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 59.48  E-value: 6.27e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd15403   6 VMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYWFFVL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICH---PLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYA-DGIEGYDILVAcssscpvm 192
Cdd:cd15403  86 EGVAILLIISVDRFLIIVQrqdKLNPHRAKVMIAISWVLSFCISFPSVVGWTLVEVPARApQCVLGYTESPA-------- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 fNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDN-------------------LPENQNNQMRKDKKAAKTLG 253
Cdd:cd15403 158 -DRVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRNAVRIHNhadslclsqvsklglmglqRPHQMNVDMSFKTRAFTTIL 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56605936 254 IVMGVFLLCWFP----CFFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15403 237 ILFVGFSLCWLPhtvfSLLSVFSRRFYYSSSFYPISTCVLWLSYLKSVFNPVIYCWRIKKFREA 300
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
29-314 7.21e-10

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 59.02  E-value: 7.21e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  29 GVRAAMYSLMACAIfitIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGF-----TIMPYSMVRSVENCWYF---G 100
Cdd:cd15102   1 GATSVVFVAICCFI---VLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAaylanILLSGARTLRLSPAQWFlreG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 101 LTFCKIHysfdlmlsiTSIFHLCSVAVDRFYAICHPLHYCTKMTipvVRRLLLV--CWSVpgafafGVVFSEAYADGIEG 178
Cdd:cd15102  78 SMFVALS---------ASVFSLLAIAIERHLTMAKMKPYGASKT---SRVLLLIgaCWLI------SLLLGGLPILGWNC 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 179 YDILVACSSSCPVMFNK--LWGTTLFVAGFFTpssmMVGIYGKIFAVSKKHARvidnlpeNQNNQMRKDKKAA--KTLGI 254
Cdd:cd15102 140 LGALDACSTVLPLYSKHyvLFCVTIFAGILAA----IVALYARIYCLVRASGR-------KATRASASPRSLAllKTVLI 208
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56605936 255 VMGVFLLCWFPCFFTILLDPFLNFSTPAVLFDAlTWF---GYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15102 209 VLLVFIACWGPLFILLLLDVACPVKTCPILYKA-DWFlalAVLNSALNPIIYTLRSRELRRAV 270
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
65-312 7.32e-10

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 58.91  E-value: 7.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  65 PTNLLILSMAVTDFLLGFtIMPYSM---VRSVEncWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRFYAICHPLHYCT 141
Cdd:cd15201  34 SSTVYLFNLAVADFLLII-CLPFRTdyyLRGKH--WKFGDIPCRIVLFMLAMNRAGSIFFLTAVAVDRYFRVVHPHHRIN 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 142 KMTIPVVRRLLLVCWSVPGAFAfGVVFSEAYADGIEGydiLVACSS--SCPVM-FNKLWGTTLFVAGFFTPSSMMvgiyg 218
Cdd:cd15201 111 SISVRKAAIIACGLWLLTIAMT-VYLLTKKHLFPRGN---ATQCESfnICTGTdSSSNWHEAMFLLEFFLPLAII----- 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 219 kIFAVskkhARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLN---------FSTPAVLFDALT 289
Cdd:cd15201 182 -LYCS----VRIIWQLRGRQLDRHAKIKRAVQFIMVVAIVFIICFLPSNVTRIAIWILKhtsnedcqyYRSVDLAFYITI 256
                       250       260
                ....*....|....*....|...
gi 56605936 290 WFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15201 257 SFTYFNSMLDPVVYYFSSPSFKN 279
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
44-157 9.14e-10

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 58.64  E-value: 9.14e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15944  26 VNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGFVDAECYVLA 105
                        90       100       110
                ....*....|....*....|....*....|....
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWS 157
Cdd:cd15944 106 AMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYL 139
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
32-314 1.92e-09

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 57.58  E-value: 1.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMaCAIfiTIFGNLAMIISISYFKQLH-TPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSF 110
Cdd:cd15925   4 ALAYGLV-CAI--GLLGNLAVMYLLRNCARRApPPIDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 111 DLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgafAFGVVFSEAyadgIEGYDILVACSSSCP 190
Cdd:cd15925  81 TVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAA----ALLATVPTA----IFATEGEVCGVELCL 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 VMF--NKLWGT---TLFVAGFFTPSSMMVGIYGKIFAVSKKHArvidnlpENQNNQmRKDKKAAKTLGIVMGVFLLCWFP 265
Cdd:cd15925 153 LKFpsNYWLGAyhlQRVVVAFVVPLGVITTSYLLLLSFLQQHK-------VNQNNR-QRQSVIARSVRLVVASFFLCWFP 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56605936 266 ----CFFTILL--------DPFLNFSTpaVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15925 225 nhvvTFWGVLVkfravpwnSTFYFIHT--YVFPVTTCLAHSNSCLNPVLYCLMRREFRQAL 283
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
44-159 3.24e-09

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 56.85  E-value: 3.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15235  14 LTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLA 93
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVP 159
Cdd:cd15235  94 VMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLS 129
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
46-314 4.54e-09

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 56.75  E-value: 4.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  46 IFGNLAMIISISYFKQLHTPtNLLILSMAVTD--FLLGFTIMPYSMVRSVEncWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15339  15 LVGNILVLFTIIRSRKKTVP-DIYVCNLAVADlvHIIVMPFLIHQWARGGE--WVFGSPLCTIITSLDTCNQFACSAIMT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseaYADGIEGYDILVACSSSCPVMFNKLWGTT-LF 202
Cdd:cd15339  92 AMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWV---YAKVIKFRDGLESCAFNLTSPDDVLWYTLyQT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 203 VAGFFTPSSMMVGIYGKIFA-VSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDpfLNFSTP 281
Cdd:cd15339 169 ITTFFFPLPLILICYILILCyTWEMYRKNKKAGRYNTSIPRQRVMRLTKMVLVLVGVFLVSAAPYHVIQLVN--LSVSQP 246
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 56605936 282 AVLFDALTW----FGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15339 247 TLAFYVSYYlsicLSYASSSINPFLYILLSGNFRKRL 283
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
43-312 4.79e-09

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 56.45  E-value: 4.79e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGF-----TIMPYSMVRSVEN---CWYFGlTFCKIHYSFDLML 114
Cdd:cd15136  12 LLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIylgllAIVDAKTLGEYYNyaiDWQTG-AGCKTAGFLAVFS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseayadGIEGYdilvACSSSCPVMFN 194
Cdd:cd15136  91 SELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLV------GVSSY----SKTSICLPFET 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 195 KLWGTTLFVAGFFTPSSM----MVGIYGKIFAVskkharvidnLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFP-CFFT 269
Cdd:cd15136 161 ETPVSKAYVIFLLLFNGLafliICGCYIKIYLS----------VRGSGRAANSNDTRIAKRMALLVFTDFLCWAPiAFFG 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 56605936 270 I---LLDPFLNFSTPAVLfdaLTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15136 231 LtaaFGLPLISVSNAKIL---LVFFYPLNSCANPFLYAIFTKQFRR 273
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
49-314 5.27e-09

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 56.43  E-value: 5.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  49 NLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMpysmvrsvencWYFGLTFCKIHYSFDLMLSIT-------SIFH 121
Cdd:cd15963  18 NAIVVAVIFYTPAFRAPMFLLIGSLATADLLAGLGLI-----------LHFAFVYCIQSAPVNLVTVGLlapsftaSVSS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 122 LCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseayadGIEGYDILVACSSSCPVMFNKLwgtTL 201
Cdd:cd15963  87 LLAITIDRYLSLYNALTYYSERTVTRTYIMLILTWGASLCLGLLPVV------GWNCLKDPSTCSVVKPLTKNHL---VI 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 202 FVAGFFTPSSMMVGIYGKIFAVSKKHARVI----DNLPENQNNQMRKdkkAAKTLGIVMGVFLLCWFPCFFTILLDpflN 277
Cdd:cd15963 158 LSISFFMVFALMLQLYAQICRIVCRHAHQIalqrHFLPTSHYVTTRK---GIATLAVILGTFASCWLPFAVYCLLG---D 231
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 56605936 278 FSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15963 232 YTYPALYTYATLLPATYNSMINPIIYAFRNQEIQKVL 268
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
37-168 6.07e-09

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 56.70  E-value: 6.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENC-WYFGLTFCKIHYSFDLMLS 115
Cdd:cd15005   6 TLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSgWIYGALSCKVIAFLAVLFC 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVF 168
Cdd:cd15005  86 FHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVF 138
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
66-314 6.56e-09

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 56.26  E-value: 6.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  66 TNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRFYAICHP-----LHYC 140
Cdd:cd15002  36 IDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPtkqvtIKQR 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 141 TkmtipvVRRLLLVCWSVPGA-----FAFGVVFSEayadgiEGYDILVACSSSCPVMFNKLWGTTLFVAGFFTPSSMMVG 215
Cdd:cd15002 116 R------ITAVVASIWVPACLlplpqWLFRTVKQS------EGVYLCILCIPPLAHEFMSAFVKLYPLFVFCLPLTFALF 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 216 IYGKIFAVSKKHARVIDNLpenqNNQMRKdKKAAKTLGIVMGVFLLCWFP--CFFTILLDPFLNFSTPAVLFDALTWFGY 293
Cdd:cd15002 184 YFWRAYGQCQRRGTKTQNL----RNQIRS-RKLTHMLLSVVLAFTILWLPewVAWLWLIHIKSSGSSPPQLFNVLAQLLA 258
                       250       260
                ....*....|....*....|..
gi 56605936 294 F-NSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15002 259 FsISSVNPIIFLLMSEEFREGF 280
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
33-133 7.26e-09

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 55.93  E-value: 7.26e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMAcaiFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVrSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15175   5 AMYSVIC---FLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLT-LPFWAA-SAAKKWVFGEEMCKAVYCLYK 79
                        90       100
                ....*....|....*....|.
gi 56605936 113 MLSITSIFHLCSVAVDRFYAI 133
Cdd:cd15175  80 MSFFSGMLLLMCISIDRYFAI 100
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
41-314 7.99e-09

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 55.90  E-value: 7.99e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  41 AIFITIFGNlAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSV-ENCWYFGLTFCKIHYSFDLMLSITSI 119
Cdd:cd15117  10 AFVLGTLGN-GLVIWVTGFRMTRTVTTVCFLNLAVADFAFCLF-LPFSVVYTAlGFHWPFGWFLCKLYSTLVVFNLFASV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 120 FHLCSVAVDRFYAICHPLHYCTKMTipvVRRLLLVCWsvpGAFAFGVVFSEA---YADGIEGYDIlVAC---------SS 187
Cdd:cd15117  88 FLLTLISLDRCVSVLWPVWARNHRT---PARAALVAV---GAWLLALALSGPhlvFRDTRKENGC-THCylnfdpwneTA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 188 SCPVMFNKLWGTTL-------FVAGFFTPSSMMVGIYGKIfavskkHARVidnlpenQNNQMRKDKKAAKTLGIVMGVFL 260
Cdd:cd15117 161 EDPVLWLETVVQRLsaqvitrFVLGFLVPLVIIGGCYGLI------AARL-------WREGWVHSSRPFRVLTAVVAAFF 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56605936 261 LCWFPCFFTILL------DPFLNFSTPAVLFDALTWF-GYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15117 228 LCWFPFHLVSLLelvvilNQKEDLNPLLILLLPLSSSlACVNSCLNPLLYVFVGRDFRERL 288
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
34-314 8.10e-09

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 55.90  E-value: 8.10e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMaCAIFITifGNLAMIISISYFKQLHTPTNLLILSMAVTDFLlgFT-IMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15087   6 IYSVI-CAVGLT--GNTAVIYVILRAPKMKTVTNVFILNLAIADDL--FTlVLPINIAEHLLQQWPFGELLCKLILSIDH 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHyCTKMTIPVVRRLLLVCWSVPGAFAFGV----VFSEAYADGIEGYDILVACSSS 188
Cdd:cd15087  81 YNIFSSIYFLTVMSVDRYLVVLATVR-SRRMPYRTYRAAKIVSLCVWLLVTIIVlpftVFAGVYSNELGRKSCVLSFPSP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 189 CPVMFNKLWGTTLfVAGFFTPSSMMVGIYGKIFAVSKKHarvidNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFF 268
Cdd:cd15087 160 ESLWFKASRIYTL-VLGFAIPVSTICILYTMMLYKLRNM-----RLNSNAKALDKAKKKVTLMVLVVLAVCLFCWTPFHL 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56605936 269 TILLDPFLNF-STPAV--LFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15087 234 STVVALTTDLpQTPLVigISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
40-168 8.83e-09

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 55.76  E-value: 8.83e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPysmvRSVENCWY------FG--LT--FCkIHY 108
Cdd:cd15221   8 CSMYIVaLLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVP----KMLAIFWFgageisFDgcLTqmFF-VHF 82
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 109 SFDLMLSItsifhLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVF 168
Cdd:cd15221  83 VFVTESAI-----LLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVF 137
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
44-156 9.04e-09

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 55.57  E-value: 9.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd13954  13 LTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFLLA 92
                        90       100       110
                ....*....|....*....|....*....|...
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd13954  93 VMAYDRYVAICHPLHYPTIMNKRVCILLAAGSW 125
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
43-169 1.02e-08

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 55.74  E-value: 1.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15410  25 GITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKAISYSGCMLQFFFFCTFVVTESFLL 104
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTipvvRRLllvCWS-VPGAFAFGVVFS 169
Cdd:cd15410 105 AVMAYDRYVAICNPLLYTVIMS----RKL---CVLlVAGSYLWGIVCS 145
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
32-314 1.17e-08

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 55.59  E-value: 1.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACaifITIFGNLAMIISISYFKQLHT--PTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYS 109
Cdd:cd14976   4 SVVYMVVFT---VGLLGNLLVLYLLKSNKKLRQqsESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 110 FDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAfgvVFSEAYADGIEGYDILVACSSSC 189
Cdd:cd14976  81 VTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAA---IPEAIFSTDTWSSVNHTLCLLRF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 190 PVMFNKLWGTTLFvaGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFP---- 265
Cdd:cd14976 158 PKNSSVTRWYNWL--GMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGGSKRRKSRVTKSVFIVVLSFFICWLPnqal 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 56605936 266 CFFTILL--------DPFLNFSTPAvlFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd14976 236 SLWSALIkfddvpfsDAFFAFQTYA--FPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
40-265 1.22e-08

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 55.47  E-value: 1.22e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTImPYSMVR-SVENCWYFGLTFCKI-HYSFDLMLsIT 117
Cdd:cd15967   9 LVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTL-PFLVVYyLKGRKWIFGQVFCKItRFCFNLNL-YG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 118 SIFHLCSVAVDRFYAICHPLHYCTKMT------IPVVRRLLLVCWSVPGAFafgvvFSEAYADGIEGYDILVACSSSCPV 191
Cdd:cd15967  87 SIGFLTCISVYRYLAIVHPMRVMGRITtthsvvISALVWLLVVIQSLPDLF-----FSKTNSNGTKCFDTTFNDYLESYL 161
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56605936 192 MFNKLWGTTlfvaGFFTPSSMMVGIYGKIFAVSKKharvidnlpenqNNQMRKD--KKAAKTLGIVMGVFLLCWFP 265
Cdd:cd15967 162 TYSLGWTVT----GFVIPLLIILGCYGHVVVVLCR------------NNNVDKGlkQRCLKLVIILIVLFSVCYIP 221
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
43-265 1.29e-08

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 55.55  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936   43 FITIFGNLAMIISISYFKqLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:PHA03087  52 FFGLVGNIIVIYVLTKTK-IKTPMDIYLLNLAVSDLLFVMT-LPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFI 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYAdgiEGYDILVACSS-SCPVMFNKLWGTTL 201
Cdd:PHA03087 130 TVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTK---KDHETLICCMFyNNKTMNWKLFINFE 206
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56605936  202 F-VAGFFTPSSMMVGIYGKIFAVSKKHarvidnlpenqnNQMRKDKKAAKTLGIVMGVFLLCWFP 265
Cdd:PHA03087 207 InIIGMLIPLTILLYCYSKILITLKGI------------NKSKKNKKAIKLVLIIVILFVIFWLP 259
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
45-167 1.41e-08

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 55.13  E-value: 1.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  45 TIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCS 124
Cdd:cd15424  14 TILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLLLGA 93
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 56605936 125 VAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSvpGAFAFGVV 167
Cdd:cd15424  94 MAYDRYLAICHPLLYAAAMGRWRQLQLALSCWA--IGFLLSVI 134
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
44-156 1.65e-08

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 54.80  E-value: 1.65e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLaMIISISYF-KQLHTPTNLLILSMAVTDFLLGFTIMP---YSMVRSVENCWYFGltfCKIHYSFDLMLSITSI 119
Cdd:cd15912  13 LTLLGNL-LIITITLVdHRLHTPMYFFLRNFSFLEILFTSVVIPkmlANLLSGKKTISFAG---CFAQSFFYFFLGTTEF 88
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 56605936 120 FHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15912  89 FLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSW 125
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
37-305 1.67e-08

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 54.81  E-value: 1.67e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYF--KQLHTPTNLLILSMAVTDFLLgFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLML 114
Cdd:cd15122   6 FLLLAALLGLPGNGFIIWSILWKmkARGRSVTCILILNLAVADGAV-LLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAF-GVVFSEAYADGIEGYDILVAC-SSSCPVM 192
Cdd:cd15122  85 MYASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALpAFVYRHVWKDEGMNDRICEPChASRGHAI 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNKLWGTtlfVAGFFTPSSMMVGIYGKIFAVSKkharvidnlpenqNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILL 272
Cdd:cd15122 165 FHYTFET---LVAFVLPFGVILFSYSVILVRLK-------------GARFRRRARVEKLIAAIVVAFALLWVPYHVVNLL 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 56605936 273 DPFLNFSTPAVLFD----------ALTWFGYFNSTCNPLIYGF 305
Cdd:cd15122 229 QVVANLAPGEVLEKlggaakaaraGATALAFFSSSVNPLLYVF 271
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
44-156 1.72e-08

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 54.63  E-value: 1.72e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15913  13 LTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTECFFLS 92
                        90       100       110
                ....*....|....*....|....*....|...
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15913  93 VMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCW 125
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
44-169 2.05e-08

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 54.62  E-value: 2.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15419  13 VTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGFLLA 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLllvcwsVPGAFAFGVVFS 169
Cdd:cd15419  93 AMAYDRFIAICNPLLYPVIMSRRVCVQL------VAGSYLCGCINS 132
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
40-314 2.07e-08

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 54.76  E-value: 2.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFITIF-GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITS 118
Cdd:cd15191   8 SIIFILGFlGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLTLNLFAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 119 IFHLCSVAVDRFYAICHPLHYCTKMTipvvRRLLLVCWSVPGAFAFG----VVFSEAYAdgIEGYDIlVACSSSCPVMFN 194
Cdd:cd15191  88 IFFITCMSVDRYLAVVYPLRSQRRRS----WQARLVCLLVWVLACLSslptFYFRDTYY--IEELGV-NACIMAFPNEKY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 195 KLWGTTLFVA----GFFTPSSMMVGIYGKIfavskkhARVIDNLPENQNNQMRKDKKAAKTLGIVMGvFLLCWFPCFFTI 270
Cdd:cd15191 161 AQWSAGLALMkntlGFLIPLIVIATCYFGI-------GRHLLKTKGFGKNKQRRDKVLKMVAAVVLA-FLICWFPFHVLT 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56605936 271 LLDPF------LNFSTPAVLFDALTWF---GYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15191 233 FLDALarmgviNNCWVITVIDKALPFAiclGFSNSCINPFLYCFVGNHFREKL 285
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
32-158 2.20e-08

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 54.33  E-value: 2.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15429   1 LGLFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFIS 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSV 158
Cdd:cd15429  81 LALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTS 127
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
40-314 2.43e-08

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 54.48  E-value: 2.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITS 118
Cdd:cd15194   8 CLVFLVgAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYIISVNMYCS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 119 IFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAyadgIEGYDILVACSSSCPVMFNKLWG 198
Cdd:cd15194  88 VFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRE----LKKYEEKEYCNEDAGTPSKVIFS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 199 TTLFVAGFFTPSSMMVGIYGKIfavskkhARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPC-FFTIL------ 271
Cdd:cd15194 164 LVSLIVAFFLPLLSILTCYCTI-------IWKLCHHYQKSGKHQKKLRKSIKIVFIVVAAFVFSWMPFnLFKALaiasgl 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56605936 272 --LDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15194 237 qvEVTCLPYTLAQLGMEVSAPLAFANSCANPFIYYFFDRYIRRAI 281
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
35-314 2.59e-08

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 54.42  E-value: 2.59e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  35 YSLMACAIFI----TIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSF 110
Cdd:cd15082  13 FTVLAALMFVvtslSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVLEGFA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 111 DLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVcWSvpgafaFGVVFSEAYADGIEGYDILVACSSSCP 190
Cdd:cd15082  93 VTFFGIVALWSLAVLAFERFFVICRPLGNIRLQGKHAALGLLFV-WT------FSFIWTIPPVLGWSSYTVSKIGTTCEP 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 -----VMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFavskKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFP 265
Cdd:cd15082 166 nwysgNMHDHTYIITFFTTCFILPLGVIFVSYGKLL----QKLRKVSNTQGRLGNARKPERQVTRMVVVMIVAFMVCWTP 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 266 -CFFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15082 242 yAAFSILVTAHPTIHLDPRLAAIPAFFSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
44-163 3.30e-08

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 54.02  E-value: 3.30e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15428  13 MTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECALLS 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWsVPGAFA 163
Cdd:cd15428  93 VMSYDRYVAICLPLRYSLIMTWKVCISLATGSW-VGGLLV 131
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
44-168 4.04e-08

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 53.52  E-value: 4.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15416  13 VTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECFLLA 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVvrRLLLVCWSVPGAFAFGVVF 168
Cdd:cd15416  93 AMAYDRYVAICNPLLYSTIMSQKV--CVLLVAASYLGGCLNALVF 135
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
43-156 4.07e-08

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 53.58  E-value: 4.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15407  12 LITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENFLL 91
                        90       100       110
                ....*....|....*....|....*....|....
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15407  92 ASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCY 125
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
67-314 4.19e-08

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 53.75  E-value: 4.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  67 NLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRFYAICHPLHY------C 140
Cdd:cd15926  37 NLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYVTAMNMYASVFFLTAMSVARYHSVASALKSkrrrgcC 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 141 TKMTIPVVRRLLLVCWSVPGAfafgvVFSEAyadgiegydILVACSSSCPVMFNKLWGTTLFVAGFFTPSSMMVGIYGKI 220
Cdd:cd15926 117 SAKWLCVLIWVLAILASLPNA-----IFSTT---------ATVSNEELCLVKFPDNRGNAQFWLGLYHAQKVLLGFLIPL 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 221 FAVSKKH---ARVIDNLPENQNNQMRKdKKAAKTLGIVMGVFLLCWFP----------CFFTILLDPFLNFSTPAVLFDA 287
Cdd:cd15926 183 GIISLCYlllVRFITDKNITGSSTKRR-SKVTKSVTIVVLSFFLCWLPnqalttwgilIKLNVVHFSYEYFTTQVYIFPI 261
                       250       260
                ....*....|....*....|....*..
gi 56605936 288 LTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15926 262 TVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
40-311 5.24e-08

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 53.62  E-value: 5.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFITIF-----GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENC-WYFGLTFCKIHYSFDLM 113
Cdd:cd15358   4 CVTYLLIFvvgavGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNYpFLLGAGGCYFKTLLFET 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW------SVPGAFAFGVVFSEAYADGIegydilVACSS 187
Cdd:cd15358  84 VCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWvvsilcSIPNTSLHGIFQLTVPCRGP------VPDSA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 188 SC----PVMFNKLWGTTLFVAGFFTPSSMMVGIY---------GKIFAVSKKHARVIDNLPENQNNQM--RKDKKAAKTL 252
Cdd:cd15358 158 TCmlvkPRWMYNLIIQITTLLFFFLPMGTISVLYlliglqlkrEKMLLVLEAKGSKAGDSYQHRRIQQekRRRRQVTKML 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56605936 253 GIVMGVFLLCWFPCFFTILLDPFLNFSTpAVLFDALTW-------FGYFNSTCNPLIYGFFYPWFR 311
Cdd:cd15358 238 FVLVVVFGICWAPFHTDRLMWSFISQWT-GELHLAFQYvhiisgvFFYLSSAANPVLYNLMSTRFR 302
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
34-158 5.26e-08

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 53.42  E-value: 5.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVR--SVENCWYFGLTFCKIhYSFD 111
Cdd:cd15232   3 LFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNllTERKTISFGGCMAQL-YFFT 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 56605936 112 LMLSiTSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSV 158
Cdd:cd15232  82 WSLG-SELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAI 127
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
43-157 6.07e-08

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 53.05  E-value: 6.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15237  12 LLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVLL 91
                        90       100       110
                ....*....|....*....|....*....|....*
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWS 157
Cdd:cd15237  92 AVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWA 126
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
44-222 6.09e-08

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 53.14  E-value: 6.09e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15406  22 VTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAECYMLT 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 124 SVAVDRFYAICHPLHYCTKMT-------IPVVRRLLLVCWSVPGAFAFGVVFSEayADGIEGY--DIL----VACSSScp 190
Cdd:cd15406 102 AMAYDRYVAICNPLLYNVTMSprvcsllVAGVYIMGLIGATVHTSCMLRLSFCG--DNVINHYfcDILpllkLSCSST-- 177
                       170       180       190
                ....*....|....*....|....*....|....
gi 56605936 191 vMFNKLWGttLFVAGF--FTPSSMMVGIYGKIFA 222
Cdd:cd15406 178 -YINELLL--FIVGGFnvLATTLAILISYAFILS 208
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
46-314 6.68e-08

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 53.09  E-value: 6.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  46 IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCK-IHYSFDLMLsITSIFHLCS 124
Cdd:cd15168  15 LLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKlVRFLFYFNL-YGSILFLTC 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 125 VAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgafAFGVVFSEAYADGIEGYDILVAC---SSSCPVMFNKLWGTTL 201
Cdd:cd15168  94 ISVHRYLGICHPLRSLGKLKKRHAVAISVAVWIL----VLLQLLPILFFATTGRKNNRTTCydtTSPEELNDYVIYSMVL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 202 FVAGFFTPSSMMVGIYGKIfavskkhARVIDNLPENQNNQMRKdKKAAKTLGIVMGVFLLCWFPcfFTILLDPFLNF--- 278
Cdd:cd15168 170 TGLGFLLPLLIILACYGLI-------VRALIRKLGEGVTSALR-RKSIRLVIIVLALFAVCFLP--FHVTRTINLAArll 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56605936 279 --STPAVLFDALTWF-------GYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15168 240 sgTASCATLNGIYVAykvtrplASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
28-314 6.85e-08

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 53.33  E-value: 6.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  28 LGVRAAMYSLMACAIFITifgNLAMIISISYfKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIH 107
Cdd:cd15084  11 LTVAVLMGMVVALASFVN---GLVIVVSIKY-KKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFE 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 108 ysfDLMLSITSIFHLCSVAV---DRFYAICHPL--------HYCTKMTIPVVRRLLlvcWSVPGAFAFGVVFSEAYAdgi 176
Cdd:cd15084  87 ---GFMVSLTGIVGLWSLAIlafERYLVICKPMgdfrfqqrHAVSGCAFTWGWSLL---WTSPPLFGWSSYVPEGLR--- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 177 egydilvacSSSCPVMF-----NKLWGTTLFVAGFFTPSSMMVGIYGKIFAVskkhARVIDNLPENQNNQMRKDKKAAKT 251
Cdd:cd15084 158 ---------TSCGPNWYtggtnNNSYILALFVTCFALPLSTIIFSYSNLLLT----LRAVAAQQKESETTQRAEKEVTRM 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56605936 252 LGIVMGVFLLCWFP-CFFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15084 225 VIAMVMAFLICWLPyATFAMVVATNKDVVIQPTLASLPSYFSKTATVYNPIIYVFMNKQFRSCL 288
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
32-303 8.74e-08

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 52.83  E-value: 8.74e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMaCAIFITifGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTImPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd14999   3 GTVLSLM-CVVGVA--GNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTI-PFYVSTYFLKKWYFGDVGCRLLFSLD 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHycTKMTIPVVRRLL-LVCW------SVPGAFAFGVVfsEAYADGIEGYDILVA 184
Cdd:cd14999  79 FLTMHASIFTLTVMSTERYLAVVKPLD--TVKRSKSYRKLLaGVIWllslllTLPMAIMIRLV--TVEDKSGGSKRICLP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 185 CSSScpvMFNKLWGTTLFVAGFFTPSSMMVGIYGKIfavSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMgVFLLCWF 264
Cdd:cd14999 155 TWSE---ESYKVYLTLLFSTSIVIPGLVIGYLYIRL---ARKYWLSQAAASNSSRKRLPKQKVLKMIFTIVL-VFWACFL 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56605936 265 PCFFTILLDPFLNFSTPA-----VLFDALTWFGYFNSTCNPLIY 303
Cdd:cd14999 228 PFWIWQLLYLYSPSLSLSprtttYVNYLLTCLTYSNSCINPFLY 271
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
44-169 1.00e-07

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 52.71  E-value: 1.00e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15408  26 ITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVFATTECYLLA 105
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTipvvRRlllVCWS-VPGAFAFGVVFS 169
Cdd:cd15408 106 AMAYDRYVAICNPLLYTVIMS----QR---VCVSlVAGSYLAGFLNS 145
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
48-314 1.36e-07

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 52.06  E-value: 1.36e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  48 GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENcWYFGLTFCKIHYSFDLMLSITSIFHLCSVAV 127
Cdd:cd15181  17 GNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLT-FPFSVVESIAG-WVFGTFLCKLVGAIHKLNFYCSSLLLACISV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 128 DRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAF-GVVFSEAYADgieGYDILVACS-SSCPVMFNKLWGTTLF--- 202
Cdd:cd15181  95 DRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLpNLVFLEVETS---TNANRTSCSfHQYGIHESNWWLTSRFlyh 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 203 VAGFFTPSSMMVGIYgkifavskkhARVIDNLpeNQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLNFSTPA 282
Cdd:cd15181 172 VVGFFLPLLIMGYCY----------ATIVVTL--CQSSRRLQKQKAIRVAILVTLVFCLCWLPYNIVIFLDTLDDLKAVV 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56605936 283 -------VLFDALT---WFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15181 240 kncklndLLDAAITvteSLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
34-158 1.81e-07

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 51.81  E-value: 1.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLM 113
Cdd:cd15234   3 LFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLL 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSV 158
Cdd:cd15234  83 FGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLI 127
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
33-303 1.93e-07

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 51.76  E-value: 1.93e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITIFGNLAMIISISYFKQLH-TPTNLLILSMAVTDFLlGFTIMPYSMV-------RSVENCWYFGLTFC 104
Cdd:cd15099   2 AIAVLCFLAGPVTFLENILVLLTILSSTALRrRPSYLFIGSLALADML-ASVIFTISFLdfhvfhqRDSRNLFLFKLGGV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 105 KIHYSfdlmlsiTSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseayadGIEGYDILVA 184
Cdd:cd15099  81 TMAFT-------ASVGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLM------GWRCKTWDSP 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 185 CSSSCPVMFNK-LWGTTLFVAGFFtpsSMMVGIYGKIFAVSKKH-ARVIDNLPENQN----NQMRKDKKAAKTLGIVMGV 258
Cdd:cd15099 148 CSRLFPYIDRHyLASWTGLQLVLL---FLIIYAYPYILWKAHRHeANMGGPKLGRQQvkgqARMRMDIRLAKTLSLILLV 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 56605936 259 FLLCWFPCFFTILLDPFLNFSTPA-VLFDALTWFGYFNSTCNPLIY 303
Cdd:cd15099 225 LAICWLPVLAFMLVDVRVTLTNKQkRMFAFCSMLCLVNSCVNPIIY 270
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
29-314 2.09e-07

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 51.41  E-value: 2.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  29 GVRAAMYSLMacaIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENCWYFGLTFCKIHY 108
Cdd:cd15183   1 TLLPPLYSLV---FIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFT-LPFWIDYKLKDDWIFGDAMCKFLS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 109 SFDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTI------PVVRRLLLVCWSVPGAFAFGVVFSEAYAdgiegydil 182
Cdd:cd15183  77 GFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVtfgiitSIITWALAILASMPCLYFFKSQWEFTHH--------- 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 183 vACSSSCP----VMFNKLWGTTLFVAGFFTPSSMMVGIYgkifavskkhARVIDNLPENQNnqmRKDKKAAKTLGIVMGV 258
Cdd:cd15183 148 -TCSAHFPrkslIRWKRFQALKLNLLGLILPLLVMIICY----------TGIINILLRRPN---EKKAKAVRLIFVITLL 213
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56605936 259 FLLCWFPCFFTILLDPFLNF-STPAVL--------FDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15183 214 FFLLWTPYNLAAFVSAFQDVlFTPSCEqsqqldlaLQVTEVIAYTHCCVNPVIYVFVGERFRKYL 278
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
40-305 2.44e-07

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 51.50  E-value: 2.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFI-TIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMvrsveNCWYFGL---TF--CKIHYSFDLM 113
Cdd:cd15953   8 CLMYIvTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKAL-----CIFWFNLkeiTFsgCLTQMFFIHT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWS------VPGA-------FAFGVVFSEAYADGIEgyd 180
Cdd:cd15953  83 LSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIrgvlliLPLPlllsrlpFCANRIIPHTYCEHMA--- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 181 ilVACSSSCPVMFNKLWG--TTLFVAGFftPSSMMVGIYGKI----FAVSKKHARVidnlpenqnnqmrkdkKAAKTLGI 254
Cdd:cd15953 160 --VVKLACGDTTINRIYGlvVALLVVGL--DLLLIALSYALIiravLRLSSKKARQ----------------KALNTCTA 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56605936 255 VMGVFLLCWFPCFFTILLDPFLNFSTPAV--LFDALTWFgyFNSTCNPLIYGF 305
Cdd:cd15953 220 HICVILMSYTPALFSFLTHRFGQGIAPHIhiILANLYLL--VPPMLNPIIYGV 270
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
48-314 2.61e-07

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 51.25  E-value: 2.61e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  48 GNlAMIISISYFKQLHTPTNLLILSMAVTDFL----LGFTIMPYSMvrsvENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15114  17 GN-ALVAWVTGFEAKRSVNAVWFLNLAVADLLcclsLPILAVPIAQ----DGHWPFGAAACKLLPSLILLNMYASVLLLT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW------SVPgAFAFGVVFSEAYADGIEgydilvacsssCPVMFNKLW 197
Cdd:cd15114  92 AISADRCLLVLRPVWCQNHRRARLAWIACGAAWllalllTVP-SFIYRRIHQEHFPEKTV-----------CVVDYGGST 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 198 GTTLFVA------GFFTPSSMMVGIYGKIFAvskkharvidnlpenqNNQMRKDKKAAKTLGIVMGV---FLLCWFPCFF 268
Cdd:cd15114 160 GVEWAVAiirfllGFLGPLVVIASCHGVLLV----------------RTWSRRRQKSRRTLKVVTAVvvgFFLCWTPYHV 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56605936 269 TILL----DPFLNFSTPAVLFDALT-WFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15114 224 VGLIiaasAPNSRLLANALKADPLTvSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
44-303 2.76e-07

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 50.97  E-value: 2.76e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENcwyFGLT----FCKIHYSFDLMLSitSI 119
Cdd:cd15347  13 IIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVAFIANILLSGSVT---FRLTpvqwFIREGTAFITLSA--SV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 120 FHLCSVAVDRFYAICHPLHYCTKMTipvVRRLLLV--CWSVpgafafGVVFSEAYADGIEGYDILVACSSSCPVMFNKLw 197
Cdd:cd15347  88 FSLLAIAIERHVAITKVKLYGSDKN---CRMVLLIgaCWVI------SIVLGGLPILGWNCIGNLEDCSTVLPLYSKHY- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 198 gtTLFVAGFFTPSSM-MVGIYGKIFAVSKKHARVIDNLPEnqnnqmrkdKKAAKTLGIVMGVFLLCWFPCFFTILLDPFL 276
Cdd:cd15347 158 --ILFVVTIFSIILLsIVILYVRIYCIVRSSHAEMAAPQT---------LALLKTVTIVLGVFIVCWLPAFIILLLDTSC 226
                       250       260
                ....*....|....*....|....*....
gi 56605936 277 NFSTPAVLFDALTWFGY--FNSTCNPLIY 303
Cdd:cd15347 227 KVKSCPILYKADYFFSVatLNSALNPVIY 255
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
44-156 2.77e-07

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 51.21  E-value: 2.77e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15943  27 ITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATTECFLLA 106
                        90       100       110
                ....*....|....*....|....*....|...
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15943 107 VMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSY 139
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
33-311 2.80e-07

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 51.33  E-value: 2.80e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYsFDL 112
Cdd:cd15199   2 AYASLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALL-FML 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSIT-SIFHLCSVAVDRFYAICHP------LHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAyadgiegydilvaC 185
Cdd:cd15199  81 SLSRGvSIAFLTAVALDRYFRVVHPrgkknsLSLQAAPYISFLVWLLLVGLTIPTLLASQPKNFTE-------------C 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 186 SSSCP---VMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPenqnnqmrKDKKAAKTLGIVMGVFLLC 262
Cdd:cd15199 148 NSFSPkddEDFSDTWQEAVFFLQFLLPFGLIVFCTVRIIRRLKKRLRDVGKQP--------KLQRAMALVTSVVVVFGFC 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56605936 263 WFPCFFT-ILLDPFLNFSTPAVL------FDALTWFGYFNSTCNPLIYGFFYPWFR 311
Cdd:cd15199 220 FLPCFLArVLMLIFQNKESCNALniavhtYDVTMCLTYLNSVLDPIVYCFSSPTFR 275
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
44-158 3.49e-07

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 50.84  E-value: 3.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVrsveNCW-------YFGltfCKIHYSFDLMLSI 116
Cdd:cd15434  13 LTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLV----NLWgpdktisYVG---CAIQLFIALGLGG 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 56605936 117 TSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSV 158
Cdd:cd15434  86 TECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLI 127
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
34-167 3.65e-07

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 50.80  E-value: 3.65e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLM 113
Cdd:cd15936   3 LFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHF 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSvpGAFAFGVV 167
Cdd:cd15936  83 TGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWL--GGFAHSIV 134
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
49-314 3.70e-07

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 50.80  E-value: 3.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  49 NLAMIISISYFKQLHTPTNLLILSMAVTDFLLGF-TIMPYSMVRSVENCWYFGLTFCKIHYSFDlmlsiTSIFHLCSVAV 127
Cdd:cd15961  18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIgLILNFIFAYLLQSEAAKLVTVGLIVASFS-----ASVCSLLAITV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 128 DRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgAFAFGVVfseayadGIEGYDIL---VACSSSCPVMFNKlwgTTLFVA 204
Cdd:cd15961  93 DRYLSLYYALTYNSERTVTFTYVMLVLLWGA--SICLGLL-------PVMGWNCLadeSTCSVVRPLTKNN---AAILSV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 205 GFFTPSSMMVGIYGKIFAVSKKHARVIdNLPEN--QNNQMRKDKKAAKTLGIVMGVFLLCWFPcfFTiLLDPFLNFSTPA 282
Cdd:cd15961 161 SFLLMFALMLQLYIQICKIVMRHAHQI-ALQHHflATSHYVTTRKGVSTLAIILGTFAACWMP--FT-LYSLIADYTYPS 236
                       250       260       270
                ....*....|....*....|....*....|..
gi 56605936 283 VLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15961 237 IYTYATLLPATYNSIINPVIYAFRNQEIQKAL 268
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
37-265 4.19e-07

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 50.56  E-value: 4.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd14975   6 LLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLT-LPVWIYFLATGTWDFGLAACKGCVYVCAVSMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgAFAFGV---VFSEAYADGIEGYDILVACSSSCPVMF 193
Cdd:cd14975  85 ASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLL--AVLLATpviAFRHVEETVENGMCKYRHYSDGQLVFH 162
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56605936 194 NKLWGttlfVAGFFTPSSMMVGIYGKIfavskkharvidnLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFP 265
Cdd:cd14975 163 LLLET----VVGFAVPFTAVVLCYSCL-------------LRRLRRRRFRRRRRTGRLIASVVVAFAACWLP 217
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
31-163 4.95e-07

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 50.55  E-value: 4.95e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  31 RAAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSF 110
Cdd:cd15418   1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 56605936 111 DLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVrrLLLVCWSVPGAFA 163
Cdd:cd15418  81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLC--MGLVAASYLGGFA 131
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
39-305 5.06e-07

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 50.26  E-value: 5.06e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  39 ACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLG-------FTIMPYSMVRSVeNCWYF--GLtfckihys 109
Cdd:cd15343   8 TFCCLFIFVSNSLVIAAVVKNKRFHYPFYYLLANLAAADFFAGiayvflmFNTGPVSKTLTV-NRWFLrqGL-------- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 110 FDLMLSiTSIFHLCSVAVDRFYAICHpLHYCTKMTIPVVRRLLLVCWSVpgAFAFGVVFSEayadGIEGYDILVACSSSC 189
Cdd:cd15343  79 LDTSLS-ASLTNLLVIAVERHISIMR-MKVHSNLTKRRVTLLIALVWAI--AIFMGAVPTL----GWNCICNISACSSLA 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 190 PVM---FNKLWGTTLFVAGFftpssMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPC 266
Cdd:cd15343 151 PIYsrsYLVFWSVSNLVVFL-----IMVVVYLRIYVYVQRKTNVLSPHTSGSINRRRTPIKLMKTVMTVLGAFVICWTPG 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56605936 267 FFTILLDPfLNFSTPAVLfDALTWF---GYFNSTCNPLIYGF 305
Cdd:cd15343 226 LVVLLLDG-LNCTRCGVQ-HVKRWFlllALLNSVMNPIIYSY 265
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
33-157 5.36e-07

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 50.13  E-value: 5.36e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15940   2 AFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLH 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWS 157
Cdd:cd15940  82 LFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWL 126
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
34-156 6.25e-07

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 49.96  E-value: 6.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLM 113
Cdd:cd15231   3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15231  83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASW 125
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
40-314 7.11e-07

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 49.80  E-value: 7.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIF-ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTImPYSMVRSVENcWYFGLTFCKIHYSFDLMLSITS 118
Cdd:cd15187   8 CLLFvFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSL-PFQAYYLLDQ-WVFGNAMCKIVSGAYYIGFYSS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 119 IFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPG-AFAFGVVFSEAYADgiegyDILVACSSSCPVMFNKLW 197
Cdd:cd15187  86 MFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAIlASVPLLVFYQVASE-----DGRLQCIPFYPGQGNSWK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 198 GTTLFVA---GFFTPSSMMVGIYGKIFAVSKKharvidnlPENQNNQmrkdkKAAKTLGIVMGVFLLCWFPCFFTILLDP 274
Cdd:cd15187 161 VFTNFEVnilGLLIPFSILIFCYHNILRNLRR--------CHNQNKT-----KAIKLVFIVVIVFFLFWTPFNVVLFLDS 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56605936 275 FLNF--------STPAVLFDALTWFGYFNSTC-NPLIYGFFYPWFRRAL 314
Cdd:cd15187 228 LHSLhiidgcqnSQRLTLALHLTETISFTHCClNPVIYAFVGEKFKKHL 276
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
118-314 7.25e-07

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 49.78  E-value: 7.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 118 SIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseayadgieGYDILVA---CSSSCPvMFN 194
Cdd:cd15349  86 STFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPLL---------GWNCLCDfrsCSSLLP-LYS 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 195 KLWgtTLF-VAGFFTPSSMMVGIYGKIFA-VSKKHARVIdnlpenQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILL 272
Cdd:cd15349 156 KSY--ILFcLVIFFIILLTIIGLYFAIYClVRASGQRVI------SARSRRRSLRLLKTVLMILGAFMVCWGPLFILLLV 227
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 56605936 273 DPFLNFSTPAVLF--DALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15349 228 DFFCSSRSCKPLFgmEWVLALAVLNSAINPLIYSFRSLEVRRAV 271
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
38-162 7.27e-07

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 49.86  E-value: 7.27e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  38 MACAIFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMP------YSMVRSVEncwyfgLTFCKIHYSF 110
Cdd:cd15421   6 LILLIFLVaLTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPkmatnfLSGRKSIS------FVGCGTQIFF 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 56605936 111 DLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWsVPGAF 162
Cdd:cd15421  80 FLTLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSW-LGGSL 130
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
46-163 7.29e-07

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 49.94  E-value: 7.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  46 IFGN-LAMII-SISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWY-FGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd14981  15 VLGNlLALIVlARSSKSHKWSVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEWdGGQPLCDYFGFMMSFFGLSSLLIV 94
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFA 163
Cdd:cd14981  95 CAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIA 135
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
35-156 7.79e-07

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 49.77  E-value: 7.79e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  35 YSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLML 114
Cdd:cd15236   4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15236  84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSW 125
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
36-313 8.78e-07

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 49.45  E-value: 8.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15404   5 AVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFFWLFV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAIchpLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMfnK 195
Cdd:cd15404  85 MEGVAILLIISIDRFLII---VQKQDKLNPYRAKVLIAVSWAVSFCVAFPLAVGSPDLQIPSRAPQCVFGYTTNPGY--Q 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 196 LWGTTLFVAGFFTPSSMMVGIYGKIFavskkharvidnlpenqnNQMRKDK-KAAKTLGIVMGVFLLCWFPCFFTILLDP 274
Cdd:cd15404 160 AYVILIMLIFFFIPFMVMLYSFMGIL------------------NTVRSFKtRAFTTILILFIVFTVCWAPFTTYSLVAT 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 56605936 275 F-LNFSTPAVLFDALTWF---GYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15404 222 FnSHFYHKHNFFEISTWLlwlCYLKSALNPLIYYWRIKKFRDA 264
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
43-156 8.83e-07

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 49.72  E-value: 8.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15415  12 FITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGFLL 91
                        90       100       110
                ....*....|....*....|....*....|....
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15415  92 AVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSY 125
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
32-314 9.08e-07

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 49.49  E-value: 9.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIfitIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGfTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15346   4 SVVFIIICCFI---ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAG-VAYTANLLLSGATTYKLTPTQWFLREGSM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICH-PLHYCTKMTipvvRRLLLV--CWSVpgafafGVVFSEAYADGIEGYDILVACSSS 188
Cdd:cd15346  80 FVALSASVFSLLAIAIERYITMLKmKLHNGSNSF----RSFLLIsaCWVI------SLILGGLPIMGWNCISALSSCSTV 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 189 CPVMFNK--LWGTTLFVAGFFTpssmMVGIYGKIFAVSKKHARVIdNLPENQNNQMRKDKKAA---KTLGIVMGVFLLCW 263
Cdd:cd15346 150 LPLYHKHyiLFCTTVFTLLLLS----IVILYCRIYSLVRTRSRRL-TFRKNIRKASRSSEKSMallKTVIIVLSVFIACW 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 56605936 264 FPCFFTILLDPFLNFSTPAVLFDAlTWF---GYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15346 225 APLFILLLLDVGCKVKTCSILFKA-EYFlvlAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
50-314 9.42e-07

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 49.45  E-value: 9.42e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  50 LAMIISISYFKQlhTPTNLLILSMAVTDFL----LGFTIMPYSMVRSVENCWYFGLTFCKIHYSFdlmlsITSIFHLCSV 125
Cdd:cd15341  22 LYLILSSPKLRR--KPSYLFIGSLALADFLasvvFACSFVDFHVFHGVDSSAIFLLKLGGVTMSF-----TASLGSLLLM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 126 AVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseayadGIEGYDILVACSSSCPVMFNK-LWGTTLFVA 204
Cdd:cd15341  95 AFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYLPLM------GWNCCPLNSPCSELFPLIPNDyLLSWLLLVA 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 205 GFFtpsSMMVGIYGKIFAVSKKHARVIDNLPENQ---NNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLNFSTP 281
Cdd:cd15341 169 ILL---SGIIYTYGHVLWKAHKHVVYMEKHQDQQgpgNARMRLDVRLAKTLGLVLAVLLICWSPVLALMMHSLFTSLSDH 245
                       250       260       270
                ....*....|....*....|....*....|....
gi 56605936 282 A-VLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15341 246 IkKAFAFCSTLCLVNSMVNPIIYALRSRELRSSL 279
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
36-154 1.02e-06

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 49.59  E-value: 1.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIF-ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPySMVR---------SVENCwyFGLTFCk 105
Cdd:cd15917   4 SIPFCAMYlVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVP-KMLGifwfnareiSFDAC--LAQMFF- 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 56605936 106 IHySFDLMLSITsifhLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLV 154
Cdd:cd15917  80 IH-SFTAMESGV----LLAMAFDRYVAICYPLRYTTILTNTVVGKIGLA 123
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
43-165 1.05e-06

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 49.56  E-value: 1.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15417  12 LVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECFLL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLllvcwsVPGAFAFG 165
Cdd:cd15417  92 AAMAYDRYVAICNPLLYSVIMSPRLCVQL------VAGAYLGG 128
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
40-156 1.10e-06

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 49.35  E-value: 1.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSI 119
Cdd:cd15942   9 VVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAEC 88
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 56605936 120 FHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15942  89 FLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTW 125
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
40-155 1.11e-06

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 49.42  E-value: 1.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIF-ITIFGNLAMIISISYFKQLHTPTNLLiLSM-AVTDFLLGFTIMPySMVR---------SVENCW---YFgltfck 105
Cdd:cd15222   8 CLLYlVALLGNSTILFVIKTEPSLHEPMYYF-LSMlAVTDLGLSLSTLP-TVLGifwfnareiSFDACLaqmFF------ 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 106 IHySFDLMLSitSIfhLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVC 155
Cdd:cd15222  80 IH-TFSFMES--SV--LLAMAFDRFVAICNPLRYASILTNSRIAKIGLAI 124
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
33-133 1.12e-06

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 49.36  E-value: 1.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLmacAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVeNCWYFGLTFCKIHYSFDL 112
Cdd:cd15176   5 VFYTI---ALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFT-LPFWAADAV-NGWVLGTAMCKITSALYT 79
                        90       100
                ....*....|....*....|.
gi 56605936 113 MLSITSIFHLCSVAVDRFYAI 133
Cdd:cd15176  80 MNFSCGMQFLACISVDRYVAI 100
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
41-158 1.22e-06

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 49.41  E-value: 1.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  41 AIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIF 120
Cdd:cd15233  10 AYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCF 89
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 56605936 121 HLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSV 158
Cdd:cd15233  90 LLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCAC 127
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
51-314 1.29e-06

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 49.03  E-value: 1.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  51 AMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRF 130
Cdd:cd15118  19 LLILWVVGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFFLNMFVSGFLLAAISLDRC 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 131 YAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseaYADGIEGYDILVAC---------SSSCPVMFNKLWGTTL 201
Cdd:cd15118  99 LLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFV---FRDVIERKDGRKLCyynfalfspSPDNNHPICKQRQEGL 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 202 FVAGFFTpsSMMVGIYgkIFAVSkkHARVIDNLpenQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLD-------- 273
Cdd:cd15118 176 AISKLLL--AFLIPLV--IIAVS--YAVVSLII---RHRCRRRPGRFVRLVVSVVVSFALCWAPYHIFSIIEvmahnqhs 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 56605936 274 --PFLNFSTPAVlfdalTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15118 247 lrPLVIQGLPFA-----TTLAFLNSVLNPVLYVFSCPDFCNKI 284
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
37-311 1.38e-06

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 49.00  E-value: 1.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNlAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTImPYSMVRSVENC-WYFGLTFCKIHYSFDLMLS 115
Cdd:cd15115   6 VLSLTFLLGVPGN-GLVIWVAGLKMKRTVNTIWFLNLAVADLLCCLSL-PFSIAHLLLNGhWPYGRFLCKLLPSIIVLNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGV-VFSEAYADG---IEGYDILVACSsscpv 191
Cdd:cd15115  84 FASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVfIYRTTVTDGnhtRCGYDFLVAIT----- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 mfnklwgTTLFVAGFFTPSSMMVGIYGKI-FAVSKKHARvidnlpenqnnqmRKDKKAAKTLGIVMGVFLLCWFPCFfti 270
Cdd:cd15115 159 -------ITRAVFGFLLPLLIIAACYSFIaFRMQRGRFA-------------KSQSKTFRVIIAVVVAFFVCWAPYH--- 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 56605936 271 LLDPFLNFSTPAVLFDALTW------FGYFNSTCNPLIYGFFYPWFR 311
Cdd:cd15115 216 IIGILSLYGDPPLSKVLMSWdhlsiaLAYANSCLNPVLYVFMGKDFK 262
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
43-158 1.45e-06

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 49.13  E-value: 1.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15229  12 LLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLL 91
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSV 158
Cdd:cd15229  92 SAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWAL 127
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-265 2.00e-06

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 48.75  E-value: 2.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLML 114
Cdd:cd15977   4 TILSCVIFLVgIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKAS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSVAVDRFYAIChPLHYCTKMTIPVVRRL-LLVCW------SVPGAFAFGVVFSEAYADGIEGYDILVACSS 187
Cdd:cd15977  84 VGITVLSLCALSIDRYRAVA-SWSRIRGIGIPVWKAVeVTLIWavaiivAVPEAIAFDMVEIDYRGQTLLVCMLPMEQTS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 188 SCPVMFNKLWGTTLFVAGFFTPSSmMVGIYGKIFA---VSKKHARVIdnlpeNQNNQMRKDKKAAKTLGIVMGVFLLCWF 264
Cdd:cd15977 163 SFMRFYQDVKDWWLFGFYFCLPLA-CTGVFYTLMScemLSIKNGMRI-----ALNDHMKQRREVAKTVFCLVVIFALCWL 236

                .
gi 56605936 265 P 265
Cdd:cd15977 237 P 237
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
44-156 2.01e-06

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 48.36  E-value: 2.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15939  13 ATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFLLT 92
                        90       100       110
                ....*....|....*....|....*....|...
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15939  93 VMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAW 125
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
70-313 2.06e-06

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 48.64  E-value: 2.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  70 ILSMAVTDFLLGFTIMPYSMVRSVEN--CWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRFYAICHPLHYcTKMTIPV 147
Cdd:cd15135  42 MVSLACSDLLVLLLGMPVELYSAIWDpfATPSGNIACKIYNFLFEACSYATILNVATLSFERYIAICHPFKY-KALSGSR 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 148 VRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKLWGTT-------LFVAGFFTPSSMMVGIYGKI 220
Cdd:cd15135 121 VRLLICFVWLTSALVALPLLFAMGTEDPLEAFPSYRGTRHHCQDQKSNLTICTslsskwtVFQASIFSAFVLYLLVLASV 200
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 221 FAVSKKHARVIDNL---------PENQNNQMRK----DKKAAKT-----LGIVMGVFLLCWFP----------------- 265
Cdd:cd15135 201 AFMCRRMMRALMGSkkgavavkgPGGSVQLLRKhesaEGKTARKqtilfLGLIVGTLAVCWMPnqirrimaaakpkddwt 280
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56605936 266 -CFFT--ILLDPFLNFstpavlfdaltwFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15135 281 rSYFRayIILLPIADT------------FFYLSSVLNPLLYNLSSQQFRSV 319
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
37-169 2.07e-06

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 48.48  E-value: 2.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIF-----GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15420   1 LLLFGLFSLLYiftllGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLF 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSvpGAFAFGVVFS 169
Cdd:cd15420  81 LALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWA--CGFLLALVHV 136
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
34-314 2.56e-06

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 48.21  E-value: 2.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLmacaIFITIF-GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSmvRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15184   6 LYSL----VFIFGFvGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWA--HYAANEWVFGNAMCKLLTGLYH 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTI------PVVRRLLLVCWSVPGafafgVVFSEAYADGIEgydilVACS 186
Cdd:cd15184  80 IGFFSGIFFIILLTIDRYLAIVHAVFALKARTVtfgvvtSVVTWVVAVFASLPG-----IIFTKSQKEGSH-----YTCS 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 187 SSCPVMFNKLWGTTLF----VAGFFTPSSMMVGIYGKIFAVSKKHARvidnlpenqnnqMRKDKKAAKTLGIVMGVFLLC 262
Cdd:cd15184 150 PHFPPSQYQFWKNFQTlkmnILGLVLPLLVMIICYSGILKTLLRCRN------------EKKRHKAVRLIFTIMIVYFLF 217
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56605936 263 WFPCFFTILLDPFLNF------STPAVLFDALT---WFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15184 218 WAPYNIVLLLNTFQEFfglnncSSSNRLDQAMQvteTLGMTHCCINPVIYAFVGEKFRSYL 278
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
43-312 2.97e-06

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 48.19  E-value: 2.97e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFG---NLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSI 119
Cdd:cd15086   9 FILTFGflnNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFGIVSL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 120 FHLCSVAVDRFYAichpLHYCTKMTIPVVRRLLL---------VCWSVPGAFAFGvvfseayADGIEGYDILVACSSSCP 190
Cdd:cd15086  89 ISLAVLSYERYCT----LLRPTEADVSDYRKAWLgvggswlysLLWTLPPLLGWS-------SYGPEGPGTTCSVQWTSR 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 VMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVidnlpeNQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTI 270
Cdd:cd15086 158 SANSISYIICLFIFCLLLPFLVMVYCYGRLLYAIKQVGKI------NKSTARKREQHVLLMVVTMVICYLLCWLPYGVMA 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56605936 271 LLDPF--LNFSTPAVLFdALTWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15086 232 LLATFgkPGLVTPVASI-VPSILAKSSTVVNPIIYVFMNKQFYR 274
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
43-157 3.16e-06

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 48.00  E-value: 3.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAmIISISYFK-QLHTP-----TNLLILSMAVTDfllgfTIMPYSMVrsveNCW-------YFGltfCKIHYS 109
Cdd:cd15947  12 LLTLLGNTA-IILLSLLDpRLHTPmyfflSNLSFLDLCFTT-----SIVPQMLV----NLWgpdktisYGG---CVTQLY 78
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 56605936 110 FDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWS 157
Cdd:cd15947  79 IFLWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWL 126
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
42-278 3.23e-06

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 48.47  E-value: 3.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936   42 IFIT-IFGNlAMIISISYFKQLHTPTNLLILSMAVTD--FLLGFTIMPYSMVrsveNCWYFGLTFCKIHYSFDLMLSITS 118
Cdd:PHA02638 108 IFILgLFGN-AAIIMILFCKKIKTITDIYIFNLAISDliFVIDFPFIIYNEF----DQWIFGDFMCKVISASYYIGFFSN 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  119 IFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWS------VPGAFAF---GVVFSEAYA-DGIEGYD--ILVACS 186
Cdd:PHA02638 183 MFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWIlsliitSPAYFIFeasNIIFSAQDSnETISNYQctLIEDNE 262
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  187 SSCPVMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKkharvidnlpenqnnQMRKDK--KAAKTLGIVMGVFLLCWF 264
Cdd:PHA02638 263 KNNISFLGRILQFEINILGMFIPIIIFAFCYIKIILKLK---------------QLKKSKktKSIIIVSIIIICSLICWI 327
                        250
                 ....*....|....
gi 56605936  265 PCFFTILLDPFLNF 278
Cdd:PHA02638 328 PLNIVILFATMYSF 341
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
37-168 3.24e-06

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 48.02  E-value: 3.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVrSVEN--CWYFGLTFCKIHYSFDLML 114
Cdd:cd15217   6 LLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLV-SIRNgsAWTYSVLSCKIVAFMAVLF 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVF 168
Cdd:cd15217  85 CFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVF 138
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
45-172 3.62e-06

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 47.86  E-value: 3.62e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  45 TIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCS 124
Cdd:cd15946  14 ILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECTLFSV 93
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 56605936 125 VAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWsvpgafAFGVVFSEAY 172
Cdd:cd15946  94 MAYDRYVAICHPLRYKVIMSWGLCILMVAGSW------VCGVFSSLLH 135
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
33-312 4.13e-06

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 47.44  E-value: 4.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMacaIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHySFDL 112
Cdd:cd15193   5 ILYLII---FFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLS-SFII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLS-ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgAFAFGVVfSEAYADGIEGYDILVACSSSCPV 191
Cdd:cd15193  81 AVNrCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAV--SLVLGIP-SLVYRNLINESVCVEDSSSRFFQ 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLwgtTLFVAgFFTPSSMMVGIYGKIFAVSKKHarvidnlPENQNNQMRKDKKAAKTLGIVMGVFLLCWFP--CFFT 269
Cdd:cd15193 158 GISLA---TLFLT-FVLPLIVILFCYCSILVRLRRH-------FHGAKRTGRRRRNSLRIVFAIVTAFVLSWLPfnTLKA 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56605936 270 I-LLDPFLNFSTPAVLFDALTW-------FGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15193 227 VrLLLELGGGVLPCHTTVAIRQgltitacLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
42-265 4.35e-06

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 47.40  E-value: 4.35e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLH---TPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIhYSFDLMLSI-T 117
Cdd:cd15157   8 LIIFVLGVVGNGLSIYVFLQPSkkkTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGSHWVFGDIACRI-MSYSLYVNMyC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 118 SIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSeayadGIEGYDILVACSSSCPVMFNKL- 196
Cdd:cd15157  87 SIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSPLLSK-----GTSKYNSQTKCLDLHPSKIDKLl 161
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 -WGTTLFVAGFFTPSSMMVGIYgkIFAVskkhaRVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFP 265
Cdd:cd15157 162 iLNYIVLVVGFILPFCTLSICY--ILII-----KALLKPRVPQSKLRVSHKKALLTIIITLILFLLCFLP 224
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
36-305 4.39e-06

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 47.50  E-value: 4.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENCWYFGLTFCKI-HYSFDLML 114
Cdd:cd15121   5 AILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLT-APFFLHFLSGGGWEFGSVVCKLcHYVCGVSM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 sITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseaYADGIEGYDILVACSSSCP---- 190
Cdd:cd15121  84 -YASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPF---YRTVLKKNINMKLCIPYHPsvgh 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 VMFNKLWGTtlfVAGFFTPSSMMVGIYGKIfavskkharvidnLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTI 270
Cdd:cd15121 160 EAFQYLFET---ITGFLLPFTAIVTCYSTI-------------GRRLRSARFRRKRRTNRLVVLIIATFALFWLPYHVVN 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56605936 271 LLD---PFLNFSTPAVLFDA-------LTWFGYFNSTCNPLIYGF 305
Cdd:cd15121 224 LIQvagALQNQAGNASVLKAaklarpnVTALAFLSSSVNPVLYAF 268
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
36-306 4.79e-06

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 47.49  E-value: 4.79e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLL-GFTIMPySMVRSVENCWYFGLTFCKIHYSFDLML 114
Cdd:cd15386   5 GVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVaLFQVLP-QLIWEITYRFQGPDLLCRAVKYLQVLS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPLHYCTKmtiPVVRRLLLV--CWSVPGAFAFGVVFSEAYADGIEGYDILvacssSCPVM 192
Cdd:cd15386  84 MFASTYMLIMMTVDRYIAVCHPLRTLQQ---PSRQAYLMIgaTWLLSCILSLPQVFIFSLREVDQGSGVL-----DCWAD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 193 FNKLWG-------TTLFVagFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMR-----------------KDKKA 248
Cdd:cd15386 156 FGFPWGakayitwTTLSI--FVLPVAILIVCYSLICYEICKNLKGKTQTSRSEGGGWRtqgmpsrvssvrtisraKIRTV 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56605936 249 AKTLGIVMgVFLLCWFPcFFTILLDPFLNFSTPA-----VLFDALTWFGYFNSTCNPLIYGFF 306
Cdd:cd15386 234 KMTFVIVL-AYIACWAP-FFSVQMWSVWDENAPDedssdFAFTITMLLASLSSCCNPWIYMFF 294
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
43-314 5.85e-06

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 47.19  E-value: 5.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFtimpYSMVRSVENCWYFGLTfckIHYSFDLMLSIT----- 117
Cdd:cd15137  12 IIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGV----YLLIIASVDLYYRGVY---IKHDEEWRSSWLctfag 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 118 ---------SIFHLCSVAVDRFYAICHPLHyCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYdilvacSSS 188
Cdd:cd15137  85 flatlssevSVLILTLITLDRFICIVFPFS-GRRLGLRRAIIVLACIWLIGLLLAVLPLLPWDYFGNFYGR------SGV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 189 C-------PVMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDnlpenqNNQMRKDKKAAKTLGIVMGVFLL 261
Cdd:cd15137 158 ClplhitdERPAGWEYSVFVFLGLNFLAFVFILLSYIAMFISIRRTRKAAA------SRKSKRDMAVAKRFFLIVLTDFL 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 56605936 262 CWFPcfftILLDPFLNFSTPAVLFDALTWFGYF----NSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15137 232 CWIP----IIVIGILALSGVPIPGEVYAWVAVFvlpiNSALNPILYTLSTPKFRKKL 284
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
46-312 6.07e-06

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 47.07  E-value: 6.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  46 IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSV 125
Cdd:cd15381  15 TIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGFNWPFGEFLCKSVNAVIYMNLYSSIYFLMMV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 126 AVDRFYAICHplhyctKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAY-----ADGIEGYDIlVACSSSCPvmfNKLW--- 197
Cdd:cd15381  95 SIDRYLALVK------TMSSGRMRRPACAKLNCLIIWMFGLLMSTPMivfrtVMYFPEYNI-TACVLDYP---SEGWhva 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 198 -GTTLFVAGFFTPSSMmvgiygkIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPF- 275
Cdd:cd15381 165 lNILLNVVGFLIPLSI-------ITFCSTQIIQVLRNNKMQKFKEIQTERKATVLVLAVLLMFFICWLPFHIFTFLDTLh 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56605936 276 -LNFSTPAVLFDAL-------TWFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15381 238 kLGLISGCRWEDILdigtqiaTFLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
66-313 6.21e-06

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 47.06  E-value: 6.21e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  66 TNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTI 145
Cdd:cd15190  46 ADTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFLCKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSR 125
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 146 PVVRRLLLVCWSVPGAFAFGVVFSEAyADGIEGY-------DILVACSSSCPVMFNKLWGTTLFVAGFFTPSSMMVGIYG 218
Cdd:cd15190 126 TSGIVALGVIWLLAALLALPALILRT-TSDLEGTnkvicdmDYSGVVSNESEWAWIAGLGLSSTVLGFLLPFLIMLTCYF 204
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 219 KIFAVSKKHARVIdnlpenQNNQMRKDKKAAKTLGIVMGVFLLCWFP------CFFTILLDpFLNFSTPAVLFDAL---- 288
Cdd:cd15190 205 FIGRTVARHFSKL------RRKEDKKKRRLLKIIITLVVTFALCWLPfhlvktLYALMYLG-ILPFSCGFDLFLMNahpy 277
                       250       260
                ....*....|....*....|....*.
gi 56605936 289 -TWFGYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15190 278 aTCLAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
44-158 7.37e-06

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 46.81  E-value: 7.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15226  13 ATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVLLI 92
                        90       100       110
                ....*....|....*....|....*....|....*
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSV 158
Cdd:cd15226  93 AMAFDRYVAICKPLHYLTIMSPRMCILLVVASWII 127
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
36-304 7.83e-06

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 46.82  E-value: 7.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIF-ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSM----VRSVENCWYFGLTFCKIHYSF 110
Cdd:cd15948   5 SIPFCSAFtVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILsifwFNSREINFNACLVQMFFLHSF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 111 DLMLSITsifhLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLL------VCWSVPGAFAF-------GVVFSEAYADGIE 177
Cdd:cd15948  85 SIMESAV----LLAMAFDRYVAICNPLRYATILTNSVITKIGLaalaraVTLMTPLPFLLrrlpycrSHVIAHCYCEHMA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 178 gyDILVACSSScpvMFNKLWG--TTLFVAGF---FTPSSmMVGIYGKIFAVSKKHARVidnlpenqnnqmrkdkKAAKTL 252
Cdd:cd15948 161 --VVKLACGDT---RFNNIYGiaVALFIVGLdlmFIILS-YVFILRAVLSLASKEEQL----------------KAFGTC 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56605936 253 GIVMGVFLLCWFPCFFTILLDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYG 304
Cdd:cd15948 219 GSHICAILVFYTPVVLSSTMHRFARHVAPHVHILLANFYLLFPPMMNPIVYG 270
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
37-311 8.23e-06

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 46.77  E-value: 8.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSI 116
Cdd:cd15085   6 LMFLNATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFHLCSVAVDRFYAICHPLHyCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAyADGIEGydilvaCSSSCPVMF--- 193
Cdd:cd15085  86 VSLWSLTLLAYERYNVVCKPMG-GLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWS-SYGPEG------VQTSCSIGWeer 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 194 ---NKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLpeNQNNQMRKDKKAAKTLGIVMGVFLLCWFP---CF 267
Cdd:cd15085 158 swsNYSYLILYFLMCFVIPVAIIGFSYGNVLRSLHKLNKKIEQQ--GGKNCPEEEERAVIMVLAMVIAFLICWLPytvFA 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56605936 268 FTILLDPFLNFSTPAVLFDalTWFGYFNSTCNPLIYGFFYPWFR 311
Cdd:cd15085 236 LIVVVNPELSISPLAATMP--TYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
43-148 8.53e-06

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 46.58  E-value: 8.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTD--FLLGFTIMPYSmvrSVENCWYFGLTFCKIHYSFDLMLSITSIF 120
Cdd:cd15072  12 LVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADmgISLNALVAASS---SLLRRWPYGSEGCQAHGFQGFFTALASIC 88
                        90       100
                ....*....|....*....|....*...
gi 56605936 121 HLCSVAVDRFYAICHPLHYCTKMTIPVV 148
Cdd:cd15072  89 SSAAIAWDRYHHYCTRSKLQWSTAISLV 116
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
36-314 9.85e-06

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 46.36  E-value: 9.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTImPYSMVRSVENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15185   5 PLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTL-PFWIHYVRWNNWVFGHGMCKLLSGFYYLGL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAfgvvFSEAYADGIEGYDILVACSSSCPVMFNK 195
Cdd:cd15185  84 YSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAA----LPEFIFYETQELFEEFLCSPLYPEDTED 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 196 LW----GTTLFVAGFFTPSSMMVGIYGKIfavskkharvIDNLPENQNnqmRKDKKAAKTLGIVMGVFLLCWFPCFFTIL 271
Cdd:cd15185 160 SWkrfhALRMNIFGLALPLLIMVICYTGI----------IKTLLRCPS---KKKYKAIRLIFVIMVVFFIFWTPYNLVLL 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56605936 272 LDPF--LNFSTPA-------VLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15185 227 LSAFqsIFFETDCerskhldLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
73-312 9.85e-06

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 46.31  E-value: 9.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  73 MAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLL 152
Cdd:cd15189  42 LAAADLVFVSGLPFWAMNILNQFNWPFGELLCRVVNGVIKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLIC 121
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 153 LVCWSVPGAFAFGVVFSEAYADgIEGYDIlVACSSSCPvmfNKLWGTT----LFVAGFFTPSSMMVGIYGKIFAVSKkha 228
Cdd:cd15189 122 VLIWVVGLLLSIPTFLLRKIKA-IPDLNI-TACVLLYP---HEAWHFAhivlLNIVGFLLPLLVITFCNYNILQALR--- 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 229 rvidNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLD--------------PFLNFSTPAVLFdaltwFGYF 294
Cdd:cd15189 194 ----TREESTRCEDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDflfdvgvldecfweHFIDIGLQLAVF-----LAFS 264
                       250
                ....*....|....*...
gi 56605936 295 NSTCNPLIYGFFYPWFRR 312
Cdd:cd15189 265 NSCLNPVLYVFVGRYFRR 282
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
44-152 1.12e-05

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 46.25  E-value: 1.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15409  13 ITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLLA 92
                        90       100
                ....*....|....*....|....*....
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLL 152
Cdd:cd15409  93 AMAYDRYVAICNPLLYPVVMSNRLCVQLI 121
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
28-144 1.32e-05

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 46.28  E-value: 1.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  28 LGVRAAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIH 107
Cdd:cd15945  10 LSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCALQ 89
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 56605936 108 YSFDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMT 144
Cdd:cd15945  90 MFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMS 126
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
70-312 1.36e-05

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 46.38  E-value: 1.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  70 ILSMAVTDFLLGFTIMP---YSMVRsVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIP 146
Cdd:cd15355  42 LASLALSDLLILLLAMPvelYNFIW-VHHPWAFGDAACRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRS 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 147 VVRRLLLVCWSVPGAFAFGVVFS--EAYADGIEGYDILVA--CSSSCPVMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFA 222
Cdd:cd15355 121 RTKKFISAIWLASALLAIPMLFTmgEQNRSGTHPGGLICTpiVDTSTLKVVIQVNAFLSFLFPMLVISVLNTLIANQLTV 200
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 223 VSKKHA--RVIDNLPENQN--------NQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFL-NFSTPAVLFDALTWF 291
Cdd:cd15355 201 MVNQAEqeNQVCTIGGQRTvlsvsmepGRVQSLRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYVsDEQWTTFLYDFYHYF 280
                       250       260
                ....*....|....*....|....*...
gi 56605936 292 -------GYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15355 281 ymltnvlFYVSSAINPILYNLVSANFRQ 308
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
46-311 1.48e-05

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 45.90  E-value: 1.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  46 IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVrSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSV 125
Cdd:cd15172  15 LIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLT-LPFWAV-YEAHQWIFGNFSCKLLRGIYAINFYSGMLLLACI 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 126 AVDRFYAICH----------PLHYctKMTIPVVRRLLLVCWSVPgafafGVVFSEAYADGIEGYDIlvaCSSSCPVMFNK 195
Cdd:cd15172  93 SVDRYIAIVQatksfrlrsrTLAY--SKLICAAVWLLAILISLP-----TFIFSEVYDFGLEEQYV---CEPKYPKNSTA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 196 LWGTTLFVA-----GFFTPSSMMVGIYgkifavskkhARVIDNLPENQNNQMRkdkKAAKTLGIVMGVFLLCWFPcFFTI 270
Cdd:cd15172 163 IMWKLLVLSlqvslGFFIPLLVMIFCY----------SFIIKTLLQAQNSQRH---KAVRVVVAVVLVFLVCQVP-YNIV 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 271 LLDPFLNF----STPAVLFDALTWF-----GYFNSTCNPLIYGFFYPWFR 311
Cdd:cd15172 229 LLIEAINLgeqqSCSSEKAVAYAKTiteclAFFHCCLNPVLYAFIGVKFR 278
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
44-173 1.60e-05

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 45.87  E-value: 1.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15405  13 VTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYVLT 92
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVcwsvpgafAFGVVFSEAYA 173
Cdd:cd15405  93 AMAYDRYVAICNPLLYTVTMSPQVCSLLMLG--------SYVMGFAGAMA 134
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
48-144 1.73e-05

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 45.52  E-value: 1.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  48 GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVAV 127
Cdd:cd15227  17 GNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELALLTVMAY 96
                        90       100
                ....*....|....*....|....*
gi 56605936 128 DRFYAICHPLHY--------CTKMT 144
Cdd:cd15227  97 DRYVAICHPLHYevimnrgaCVQMA 121
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
49-312 1.75e-05

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 45.92  E-value: 1.75e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  49 NLAMIISISYFKQLHTPTNLLILSMAVTDFL----LGFTIMPYSMvrsvENCWYFGLTFCK-IHYSFDLMLSiTSIFHLC 123
Cdd:cd15968  18 NSVVLTRCCRHTKAWTRTAIYMVNLALADLLyalsLPLLIYNYAM----RDRWLFGDFMCRlVRFLFYFNLY-GSILFLT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSeAYADGIEGYdiLVACSSSCPVMFNK--LWGTTL 201
Cdd:cd15968  93 CISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIF-ARTGIIRNR--TVCYDLAPPALFPHyvPYGMAL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 202 FVAGFFTPSSMMVGIYGKifaVSKKHARVIDNLPENQNNQMRkdkKAAKTLGIVMGVFLLCWFPcfFTILLDPFLNF-ST 280
Cdd:cd15968 170 TVSGFLLPFSIILWCYCL---VVRTLCRTLGPAEPPAQARRR---KSIRTIVTVTLLFALCFLP--FHITRTIYLAVrVT 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 56605936 281 PAVLFDALTWFGYF----------NSTCNPLIYGFFYPWFRR 312
Cdd:cd15968 242 PGVPCHVLEAVAACykitrplasaNSVLNPLLYFLTKKKFGR 283
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
32-167 2.03e-05

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 45.25  E-value: 2.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15938   1 ALLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFL 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSvpGAFAFGVV 167
Cdd:cd15938  81 HFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWA--GGFLHSIV 134
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
36-148 2.16e-05

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 45.24  E-value: 2.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIF-ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLML 114
Cdd:cd15956   4 SLPFCFIYvLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAF 83
                        90       100       110
                ....*....|....*....|....*....|....
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVV 148
Cdd:cd15956  84 SAMESGVLVAMALDRFVAICNPLHYATILTLEVV 117
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
33-156 2.53e-05

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 44.97  E-value: 2.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  33 AMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15224   2 LLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFL 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15224  82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSW 125
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
40-154 2.55e-05

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 45.03  E-value: 2.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIF-ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITS 118
Cdd:cd15951   8 CIMYaVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTME 87
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 56605936 119 IFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLV 154
Cdd:cd15951  88 SGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLA 123
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
40-168 2.63e-05

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 45.18  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936    40 CAIFITIF-GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPysmvrSVENCWYFGLTFCKIHYSFDLMLSITS 118
Cdd:pfam13853   2 CLMYLIIFlGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLP-----TVLGIFWFGLREISFEACLTQMFFIHK 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 56605936   119 IF-----HLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVF 168
Cdd:pfam13853  77 FSimesaVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPF 131
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
44-156 2.74e-05

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 45.14  E-value: 2.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15225  13 VTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFLLA 92
                        90       100       110
                ....*....|....*....|....*....|...
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15225  93 AMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSW 125
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
65-314 3.03e-05

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 45.15  E-value: 3.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  65 PTNLLILSMAVTDFLLGFTiMPYSMVR-SVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKM 143
Cdd:cd14988  34 LVNLYILNMAIADLGVVLT-LPVWMLEvMLDYTWLWGSFLCKFTHYFYFANMYSSIFFLTCLSVDRYLTLTSSSPFWQQH 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 144 TIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKLWGTTLFVaGFFTPSSMmvgiygkIFAV 223
Cdd:cd14988 113 QHRIRRALCAGIWVLSAIIPLPEVVHMQLLDGVEPMCLFLAPFETYDEWALAVSLLTLII-GFLIPFSI-------IAVF 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 224 SKKHARVIDNLPENQNnqmrkdKKAAKTLGIVMGVFLLCWFPCFFTILL------DPFLNFSTPAVL---FDALTWFGYF 294
Cdd:cd14988 185 NVLTARYIRTAGRPES------RRHCLLIYAYILVFVVCWLPYHVTLLLltlhgsHISLHCNLVHFLyffYDVIDCFSLL 258
                       250       260
                ....*....|....*....|
gi 56605936 295 NSTCNPLIYGFFYPWFRRAL 314
Cdd:cd14988 259 HCVANPILYNFLSKSFRGKL 278
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
34-158 3.70e-05

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 44.91  E-value: 3.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAIFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15155   2 LYGAVYSVVFILgLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFT-LPFKIFYNFNRHWPFGDSLCKISGTAFL 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHyctKMTIPVVRRLLLVCWSV 158
Cdd:cd15155  81 TNIYGSMLFLTCISVDRFLAIVYPFR---SRTIRTRRNSAIVCAGV 123
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
46-313 4.04e-05

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 44.42  E-value: 4.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  46 IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMpYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSV 125
Cdd:cd15345  15 VLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAGIAYK-VNILMSGKKTFSLSPTQWFLREGSMFVALGASTFSLLAI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 126 AVDRFYAICHPLHYCTKMTIPVVRrLLLVCWSVpgAFAFGVVFSEayadGIEGYDILVACSSSCPVMFNKLWGTTLFVag 205
Cdd:cd15345  94 AIERHLTMIKMRPYDANKRYRVFL-LIGTCWLI--SVLLGALPIL----GWNCLDNLPDCSTILPLYSKKYVAFCISI-- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 206 FFTPSSMMVGIYGKIFAVSKKHARVIDNlpenqNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFLNFSTPAVLF 285
Cdd:cd15345 165 FIAILVAIVILYARIYILVKSSSRRVTN-----HRNSERSMALLRTVVIVVGVFIACWSPLFILLLIDVACEVKQCPILY 239
                       250       260       270
                ....*....|....*....|....*....|.
gi 56605936 286 DAlTWF---GYFNSTCNPLIYGFFYPWFRRA 313
Cdd:cd15345 240 KA-DWFialAVLNSAMNPIIYTLASKEMRRA 269
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
44-156 4.56e-05

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 44.40  E-value: 4.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMP---YSMVR-----SVENC---WYFgltFCkihysfdl 112
Cdd:cd15911  13 VTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPrmlASLLTgdrtiSVSGCivqFYF---FG-------- 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15911  82 SLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSW 125
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
36-155 4.63e-05

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 44.21  E-value: 4.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITI-FGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPysmvRSVENCWY----FGLTFCKIHYSF 110
Cdd:cd15223   4 SLPFLLLYLVAlVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILP----KMLAIFWFdantISLPGCFAQMFF 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 56605936 111 DLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVC 155
Cdd:cd15223  80 IHFFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFA 124
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
44-156 6.34e-05

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 43.96  E-value: 6.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15937  13 IILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEMFLLV 92
                        90       100       110
                ....*....|....*....|....*....|...
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15937  93 AMAYDRYVAICKPLHYTTVVNRRVCCVLVGASW 125
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
43-154 6.82e-05

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 43.94  E-value: 6.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSM----VRSVEncwyFGLTFCKIHYSFDLMLSITS 118
Cdd:cd15950  12 VIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLsifwLGSAE----ISFEACFTQMFFVHSFTAVE 87
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 56605936 119 IFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLV 154
Cdd:cd15950  88 SGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLA 123
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
36-157 7.03e-05

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 43.60  E-value: 7.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITI-FGNLAMIISISYFKQL-HTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLM 113
Cdd:cd15935   4 FVLVLACYAAIlLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHF 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWS 157
Cdd:cd15935  84 LGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWA 127
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
70-312 7.77e-05

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 43.70  E-value: 7.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  70 ILSMAVTDFLL---GFTIMPYSMVRsVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIP 146
Cdd:cd15356  42 LVSLALSDLLIlliSVPIELYNFVW-FHYPWVFGDLVCRGYYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKR 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 147 VVRRLLLVCW------SVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKLWGTTLFVAgFFTPSSMMVGIYGki 220
Cdd:cd15356 121 RTKWLLALIWasslgfALPMAFIMGQKYELETADGEPEPSSRVCTVLVSRATLKVFIQVNAFVS-FVLPLALIAFLNG-- 197
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 221 faVSKKHARVidnlpenqnnqmRKDKKAAKTLGIVMGVFLLCWFPCFFTILL----------DPFLNFSTpavLFDALT- 289
Cdd:cd15356 198 --VTVSHLRI------------QSLQHSVQVLRAIVIAYVICWLPYHARRLMfcyvpddawtDSLYNFYH---YFYMLTn 260
                       250       260
                ....*....|....*....|...
gi 56605936 290 WFGYFNSTCNPLIYGFFYPWFRR 312
Cdd:cd15356 261 TLFYVSSAVNPLLYNVVSSSFRK 283
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
34-156 8.47e-05

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 43.51  E-value: 8.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLM 113
Cdd:cd15914   3 LFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHS 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15914  83 LGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCW 125
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
44-148 8.68e-05

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 43.66  E-value: 8.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15954  13 IAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESGVLM 92
                        90       100
                ....*....|....*....|....*
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVV 148
Cdd:cd15954  93 LMALDRYVAICYPLRYATILTNPVI 117
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
37-314 9.30e-05

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 43.22  E-value: 9.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTP-TNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15219   5 LLVVVLVVSLLSNLLVLLCFLYSAELRKQvPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVrrLLLVCWSVPGAFAFGVVfseAYADGIEGYDILVAcssSCPVMFNK 195
Cdd:cd15219  85 SNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDA--ALMVGYSWLHSLTFSLV---ALFLSWLGYSSLYA---SCTLHLPR 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 196 LWGTTLFV--AGFFTPSSMMVGIYGKIFAVSKKHarvidnlpenqnnQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLD 273
Cdd:cd15219 157 EEERRRFAvfTAFFHAFTFLLSLLVLCVTYLKVL-------------KVRRRQRATKKISIFIGTFVLCFAPYVITRLVE 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56605936 274 PFLNFSTPA---VLFDALTwfgYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15219 224 LLPFVTINRywgIVSKCLT---YSKAASDPFVYSLLRQQYRKVL 264
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
32-156 9.86e-05

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 43.21  E-value: 9.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  32 AAMYSLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVE-NCWYFGLTFCKIHYSF 110
Cdd:cd15916   1 SLLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEpGGKVISFGGCVAQLYF 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 56605936 111 DLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15916  81 FHFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTW 126
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
50-314 1.22e-04

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 43.21  E-value: 1.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  50 LAMIISISYFKqLHTPTNLLILSMAVTDFLlgFTI-MPYSMVRSVENCWYFGLTFCKIHYS-FDLMLSITSIFHLCsVAV 127
Cdd:cd15154  20 VALWVFVRYLR-LHSVVSIYMCNLALSDLL--FTLsLPLRIYYYANHYWPFGNFLCQFSGSiFQMNMYGSCLFLMC-INV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 128 DRFYAICHPLHYCTKMTIPVVRRLLLVCW------SVPGAFAFGVvfSEAYADGIEGYDILVACSsscpvmfNKLWGTTL 201
Cdd:cd15154  96 DRYLAIVHPLRFRHLRRPKVARLLCLAVWalilggSVPAAIVHSS--SDCLLHGEKVYRCFESFS-------DNDWKGLL 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 202 ------FVAGFFTPSSmmvgiygkifAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPF 275
Cdd:cd15154 167 plvvlaEILGFLLPLA----------AVLYCSCRIFVELCRTQEPQQGRRRKTVRLLLVNLVIFLICFVPYNTTLAVYGL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 56605936 276 L-------NFSTPAVLFDALT---WFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15154 237 LranlvedTWNIKDTLRKVLSvtvLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
34-305 1.27e-04

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 43.21  E-value: 1.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLmacAIFITIFGNlAMIISISYFKQLHTPTNLLILSMAVTDFLLGFtIMPYSMV-RSVENCWYFGLTFCKIHySFDL 112
Cdd:cd15116   6 IYSV---VFVLGVLGN-GLVIFITGFKMKKTVNTVWFLNLAVADFLFTF-FLPFSIAyTAMDFHWPFGRFMCKLN-SFLL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 113 MLSI-TSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVpgAFAFGVVFSEAYADGIEGYDILVACSSSCPV 191
Cdd:cd15116  80 FLNMfTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVV--AFFLSSPSFIFRDTAPSQNNNKIICFNNFSL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNK--------------LWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKharvidnlpenqnNQMRKDKKAAKTLGIVMG 257
Cdd:cd15116 158 SGDNsspevnqlrnmrhqVMTITRFLLGFLIPFTIIICCYAAIVLKLKR-------------NRLAKSSKPFKIIAAVIV 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56605936 258 VFLLCWFPCFFTILLDPFLNFSTPAVLFDAL---TWFGYFNSTCNPLIYGF 305
Cdd:cd15116 225 TFFLCWAPYHILNLLEMEATRSPASVFKIGLpitSSLAFINSCLNPILYVF 275
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
40-314 1.27e-04

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 43.20  E-value: 1.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENcWYFGLTFCKIHYSFDLMLSITSI 119
Cdd:cd15174   9 LIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCT-LPFWATAASSG-WVFGTFLCKVVNSMYKINFYSCM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 120 FHLCSVAVDRFYAICHplhyCTKMTIPVVRRLL---LVCWSVpGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKL 196
Cdd:cd15174  87 LLLTCISVDRYIAIVQ----ATKAHNSKNKRLLyskLVCFFV-WLLSTILSLPEILFSQSKEEESVTTCTMVYPSNESNR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGTTLFV----AGFFTPSSMMVGIYGKIfavskkharvIDNLPENQNNQmrkDKKAAKTLGIVMGVFLLCWFPcFFTILL 272
Cdd:cd15174 162 FKVAVLAlkvtVGFFLPFVVMVICYTLI----------IHTLLQAKRFQ---KHKALKVIIAVVTVFVLSQLP-YNSILL 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56605936 273 DPFLNFSTPAVL-----------FDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15174 228 IKTINAYNITITdcatsqnldiaGQVTQSIAFLHSCLNPFLYVFVGVRFRKDL 280
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
43-311 1.35e-04

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 42.86  E-value: 1.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTD--FLLGFTIMPYSmVRSVENcWYFGLTFCKIHYSFDLMLSITSIF 120
Cdd:cd15380  12 FFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDlvFVLGLPFWAEN-IRNQFN-WPFGNFLCRVISGVIKANLFISIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 121 HLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGvVFSEAYADGIEGYDIlvacsSSCPVMF-NKLWGT 199
Cdd:cd15380  90 LVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIP-TFLFRSVKHVPDLNI-----SACILLFpHEAWHF 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 200 T----LFVAGFFTPSSMMVGIYGKIFAVSKKHARVidnlpENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLD-- 273
Cdd:cd15380 164 ArrveLNIVGFLLPLAAIVFFNFHIIASLRERTEE-----SRKRCGGLKDTKATRLILTLVLMFLVCWTPYHFFAFLDfl 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 56605936 274 ------------PFLNFStpavlFDALTWFGYFNSTCNPLIYGFFYPWFR 311
Cdd:cd15380 239 fqveviqgcfweEFIDLG-----LQLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
43-158 2.09e-04

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 42.41  E-value: 2.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15414  12 LITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFLL 91
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSV 158
Cdd:cd15414  92 ASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVV 127
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
42-164 2.14e-04

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 42.71  E-value: 2.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYsMVRSVEN--CWYFGLTFCKIHYSFDLMLSITSI 119
Cdd:cd15218  11 IGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPF-VFTSVKNgsTWTYGTLTCKVIAFLGVLSCFHTA 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 56605936 120 FHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAF 164
Cdd:cd15218  90 FMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAF 134
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
35-305 2.21e-04

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 42.44  E-value: 2.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  35 YSLMACAIFITIFGNLAMIISISY---FKQLHTPTNLLILSMAVTDFLLGFTImPYSMVRSVE-NCWYFGLTFCKI-HYS 109
Cdd:cd14987   1 YTLSFFYIFIFVIGLLANSVVVWVnlqAKRTGYETHLYILNLAIADLCVVATL-PVWVVSLVQhNQWPMGEFTCKItHLI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 110 FDLMLsITSIFHLCSVAVDRFYAICHPLHYCTKMTiPVVRRLLLV-CWsvpgAFAFGVVFSEAYADGIEGYDIL--VACS 186
Cdd:cd14987  80 FSINL-FGSIFFLTCMSVDRYLSVTLFGNTSSRRK-KIVRRIICVlVW----LLAFVASLPDTYFLKTVTSPSNneTYCR 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 187 SSCPVMFNKLWGTTL----FVAGFFTPSSMMVGIYGKIfavskkhARVIDNLPENQNnqmrkdKKAAKTLGIVMGVFLLC 262
Cdd:cd14987 154 SFYPEESFKEWLIGMelvsIVLGFVIPFPIIAVFYFLL-------ARAISASSDQER------KSSRKIIFSYVVVFLVC 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 56605936 263 WFPCFFTILLDPF-----LNFST--PAVLFDAL---TWFGYFNSTCNPLIYGF 305
Cdd:cd14987 221 WLPYHTVVLLDILsflhlIPFSCqlENFLYAALhvtQCFSLVHCCVNPILYSF 273
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
43-157 2.34e-04

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 42.29  E-value: 2.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15915  12 LASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAMLL 91
                        90       100       110
                ....*....|....*....|....*....|....*
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWS 157
Cdd:cd15915  92 AVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWV 126
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
41-137 2.37e-04

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 42.06  E-value: 2.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  41 AIFITIF-----GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENcWYFGLTFCKIHYSFDLMLS 115
Cdd:cd15923   5 AIYIPTFvlgllLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLIS-LPFKMHSYRRE-SAGLQKLCNFVLSLYYINM 82
                        90       100
                ....*....|....*....|..
gi 56605936 116 ITSIFHLCSVAVDRFYAICHPL 137
Cdd:cd15923  83 YVSIFTITAISVDRYVAIRYPL 104
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
43-305 2.47e-04

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 42.09  E-value: 2.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIM-------PYSMVRSVENcWYFGLTFckihysfdLMLS 115
Cdd:cd15342  12 VIVLLTNLLVIAAIFINRRFHYPIYYLLGNLAAADLFAGVAYLflmfhtgPWTAKLSLYQ-WFLRQGL--------LDTS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 116 IT-SIFHLCSVAVDRFYAI-CHPLHycTKMTIPVVRRLLLVCWSVpgAFAFGVVFSEayadgieGYDILVA---CSSSCP 190
Cdd:cd15342  83 LTaSVANLLAIAVERHQTIfTMQLH--SKMSNQRVVILIFGIWMV--ALILGLIPAM-------GWNCLCDlkrCSTMAP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 191 VM---FNKLWGTTLFVAgfftpSSMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCF 267
Cdd:cd15342 152 LYsrsYLVFWALSNLLT-----FLIMVAVYTRIFIYVRRKSQRMSEHHSSHPRYRETVLGLMKTVVIILGAFVVCWTPGQ 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 56605936 268 FTILLDPFLNFSTpavlfDALTWFGYF------NSTCNPLIYGF 305
Cdd:cd15342 227 VVLLLDGLGCESC-----NVLAYEKYFlllaeiNSLVNPIVYSY 265
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
35-265 2.73e-04

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 42.10  E-value: 2.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  35 YSLMACAIFIT-IFGN-LAMIISISYFKQlHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENC-WYFGLTFCKIhYSFD 111
Cdd:cd15921   3 YPTAYILIFILgLTGNsISVYVFLSQYRS-QTPVSVLMVNLAISDLLLVCT-LPLRLTYYVLNShWPFGDIACRI-ILYV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 112 LMLSI-TSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADGiegydilvACSSSC- 189
Cdd:cd15921  80 LYVNMySSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHD--------EGSTRCl 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 190 -----PVMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKharviDNLPENQNNQMRkdKKAAKTLGIVMGVFLLCWF 264
Cdd:cd15921 152 elahdAVDKLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLLK-----PSPALGRTRPSR--RKACALIIISLGIFLVCFL 224

                .
gi 56605936 265 P 265
Cdd:cd15921 225 P 225
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
44-314 3.08e-04

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 42.07  E-value: 3.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENcWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15177  13 LGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLT-LPFAAAETLQG-WIFGNAMCKLIQGLYAINFYSGFLFLT 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 124 SVAVDRFYAICH--PLHYCTKMTIPVVRRLLLVCWSVPGAFAF-GVVFSEAyadgiEGYDILVAC----SSSCPVMFNKL 196
Cdd:cd15177  91 CISVDRYVVIVRatSAHRLRPKTLFYSVLTSLIVWLLSILFALpQLIYSRV-----ENRSELSSCrmifPEVVSRTVKGA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGTTLFVAGFFTPSSMMVGIYGKIfavskkharvIDNLPENQNNQMRKdkkAAKTLGIVMGVFLLCWFPCFFTILLD--- 273
Cdd:cd15177 166 TALTQVVLGFAIPLIVMAVCYAAI----------GRTLLAARGWERHR---ALRVIAALVVAFVLFQLPYSVVLLLDtad 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 56605936 274 -------PFLNFSTPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15177 233 llatlelSCSQSKRKDIALLVTSGLAYVRCCLNPLLYAFVGVRFRRDI 280
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
37-305 3.58e-04

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 41.55  E-value: 3.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIF---GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMpYSMVRSVENCWYFGLTFCKIHYSFDLM 113
Cdd:cd15344   3 VMGLGITVCIFimlANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYF-YLMFNTGPNTRRLTVSTWLLRQGLIDT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 114 LSITSIFHLCSVAVDRFYAICHpLHYCTKMTIPVVRRLLLVCWSVpgAFAFGVVFSEAY--ADGIEGYDILVACSSSCPV 191
Cdd:cd15344  82 SLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTM--AIVMGAIPSVGWncICDIENCSNMAPLYSDSYL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLWGTTLFVagfftpssMMVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTIL 271
Cdd:cd15344 159 VFWAIFNLVTFV--------VMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLL 230
                       250       260       270
                ....*....|....*....|....*....|....
gi 56605936 272 LDPFLNFSTPAVLFDALTWFGYFNSTCNPLIYGF 305
Cdd:cd15344 231 LDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSY 264
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
60-314 3.95e-04

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 41.74  E-value: 3.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  60 KQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRFYAICHPL-- 137
Cdd:cd15080  29 KKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMsn 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 138 ----HYCTKMTIPVVRRLLLVCwSVPGAFAFGVVFSEAY--ADGIEGYDILvacssscPVMFNKLWGTTLFVAGFFTPSS 211
Cdd:cd15080 109 frfgENHAIMGVAFTWVMALAC-AAPPLVGWSRYIPEGMqcSCGIDYYTLK-------PEVNNESFVIYMFVVHFTIPLI 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 212 MMVGIYGKIFAVSKKHARvidnlPENQNNQMRKDKKAAKTLGIVMGV-FLLCWFP---CFFTILLDPFLNFStpAVLFDA 287
Cdd:cd15080 181 VIFFCYGRLVCTVKEAAA-----QQQESATTQKAEKEVTRMVIIMVIaFLICWVPyasVAFYIFTHQGSDFG--PIFMTI 253
                       250       260
                ....*....|....*....|....*..
gi 56605936 288 LTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15080 254 PAFFAKSSAVYNPVIYILMNKQFRNCM 280
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
44-156 4.18e-04

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 41.31  E-value: 4.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVR---SVENCWYFGltfCKIHYSFDLMLSITSIF 120
Cdd:cd15432  13 LTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNlrsPQKTISYGG---CVAQLFIFLGLGSTECV 89
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 56605936 121 HLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15432  90 LLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAW 125
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
44-306 4.47e-04

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 41.33  E-value: 4.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLL-GFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15198  13 AGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLViGGTALSQIIWELLGDRWMAGDVACRLLKLLQASARGASANLV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 123 CSVAVDRFYAICHPLhyctKMTIPVvRRLLLVCWSV------PGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKL 196
Cdd:cd15198  93 VLLALDRHQAIRAPL----GQPLRA-WKLAALGWLLalllalPQAYVFRVDFPDDPASAWPGHTLCRGIFAPLPRWHLQV 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHAR--VIDNLPENQNNQMR------------KDKKAAKTLGIVMgVFLLC 262
Cdd:cd15198 168 YATYEAVVGFVAPVVILGVCYGRLLLKWWERANqaPGAKKPWKKPSKSHlratapsalpraKVKTLKMTLVIAL-LFVGC 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56605936 263 WFPCFFTILLDPFLNFS-TPAVLFDALTWFGYFNSTCNPLIYGFF 306
Cdd:cd15198 247 SLPYFIAELAAAFGSGDwEPEKVAAALGVMAVANSATNPFVFLFF 291
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
37-305 4.58e-04

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 41.34  E-value: 4.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIF---GNLAMIISISYFKQLHTPTNLLILSMAVTDFLLG-------FTIMPYSMVRSVENcWYF--GLtfc 104
Cdd:cd15101   3 VMGLGITVCIFimlANLLVIAAIYKNRRFHFPIYYLLANLAAADFFAGlayfflmFNTGPNTRRLTVST-WFLrqGL--- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 105 kihysfdLMLSIT-SIFHLCSVAVDRFYAICH-PLHycTKMTIPVVRRLLLVCWSVpgAFAFGVVFSEayadgieGYDIL 182
Cdd:cd15101  79 -------LDTSLTaSVANLLAIAVERHISVMRmQLH--SRLSNRRVVVLIVLVWTM--AIVMGAIPSV-------GWNCL 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 183 VA---CSSSCPVMFNKLwgttlfvAGFFTPSSM-----MVGIYGKIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGI 254
Cdd:cd15101 141 CAidaCSNMAPLYSRSY-------LVFWAISNLvtflvMVVVYARIFVYVRRRTNRMSPHTSGSIRNRDTMMSLLKTVVI 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 56605936 255 VMGVFLLCWFPCFFTILLDPFLNFSTPAVLFDalTWF---GYFNSTCNPLIYGF 305
Cdd:cd15101 214 VLGAFVVCWTPGLVVLLLDGLCCRQCNVLAVE--KFFlllAEFNSAVNPIIYSY 265
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
97-314 4.67e-04

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 41.22  E-value: 4.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  97 WYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW---SVPGAFAFG----VVFS 169
Cdd:cd15160  66 WTFGPLSCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWvleLGTHSVFLGhdelFRDE 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 170 EAYADGIEGYDIlvacssscPVMFNKLWGTTLFVaGFFTPSSMMVGIYGKIFavskkhaRVIDNLPENQNNQMRKDKKAA 249
Cdd:cd15160 146 PNHTLCYEKYPM--------EGWQASYNYARFLV-GFLIPLSLILFFYRRVL-------RAVRQSPSLEREEKRKIIGLL 209
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56605936 250 KTLgivMGVFLLCWFPCFFTILLDPFL------------NFSTPAVLFDALTwfgYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15160 210 LSI---VVIFLLCFLPYHVVLLVRSVIelvqnglcgfekRVFTAYQISLCLT---SLNCVADPILYIFVTEDVRQDL 280
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
70-168 5.74e-04

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 41.09  E-value: 5.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  70 ILSMAVTDFLLGFTIMP---YSMVRsVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKMTIP 146
Cdd:cd15130  42 LGSLALSDLLILLLAMPvelYNFIW-VHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRS 120
                        90       100
                ....*....|....*....|..
gi 56605936 147 VVRRLLLVCWSVPGAFAFGVVF 168
Cdd:cd15130 121 RTKKFISAIWLASALLAIPMLF 142
7tmA_GPR153_GPR162-like cd14998
orphan G protein-coupled receptors 153 and 162, member of the class A family of ...
36-139 5.82e-04

orphan G protein-coupled receptors 153 and 162, member of the class A family of seven-transmembrane G protein-coupled receptors; This group contains the G-protein coupled receptor 153 (GPR153), GPR162, and similar proteins. These are orphan GCPRs with unknown endogenous ligand and function. GPR153 and GPR163 are widely expressed in the central nervous system (CNS) and share a common evolutionary ancestor due to a gene duplication event. Although categorized as members of the rhodopsin-like class A GPCRs, both GPR162 and GPR153 contain an HRM-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors which is important for efficient G protein-coupled signal transduction. Moreover, the LPxF motif, a variant of NPxxY motif that plays a crucial role during receptor activation, is found at the end of TM7 in both GPR162 and GPR153. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320129  Cd Length: 301  Bit Score: 41.08  E-value: 5.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIfITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLL-GFTIMPYSMVR----SVENCWYFGLtfCKIHYSF 110
Cdd:cd14998   6 SWLACGG-LSLLANAWGILSISAKQQKHKPLELLLCFLAGTHMLMvAVPLTTYSVVQlrrqASDYDWNEGL--CKVFVST 82
                        90       100
                ....*....|....*....|....*....
gi 56605936 111 DLMLSITSIFHLCSVAVDRFYAICHPLHY 139
Cdd:cd14998  83 FYTLTLATCFTVTSLSYHRMWMVRWPVNY 111
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
64-312 6.53e-04

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 40.89  E-value: 6.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  64 TPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRFYAICHPLHYCTKM 143
Cdd:cd15162  33 APAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAFYGNMYCSILLLTCISIDRYLAIVHPMGHRRLR 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 144 TIPVVRRLLLVCWSVPGAFAFGVVFSE-----AYADGIEGYDILVACSSScPVMFNKLwgTTLFVAGFFTPSSMMVGIYG 218
Cdd:cd15162 113 ARRYALGTCLAIWLLALLVTLPLYLVKqtiflPALDITTCHDVLPEQLLV-GDWFYYF--LSLAIVGFLIPFILTASCYV 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 219 KIFavskkhaRVIDNLPENQNNqmRKDKKAAKTLGIVMGVFLLCWFPCFFTILLD-PFLNFSTPAVLFDALT---WFGYF 294
Cdd:cd15162 190 ATI-------RTLAALEDENSE--KKKKRAIKLAATVLAIFIICFAPSNLLLLAHySLISSSGTGHLYFAYLlalCLSTL 260
                       250
                ....*....|....*...
gi 56605936 295 NSTCNPLIYGFFYPWFRR 312
Cdd:cd15162 261 NSCIDPFIYYFVSKEFRD 278
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
34-158 6.92e-04

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 40.99  E-value: 6.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  34 MYSLMACAIFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENCWYFGLTFCKIHYSFDL 112
Cdd:cd15156   2 LYGCVFSMVFVLgLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFT-LPFRIFYFVQRNWPFGDLLCKISVTLFY 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 56605936 113 MLSITSIFHLCSVAVDRFYAICHPLHyctKMTIPVVRRLLLVCWSV 158
Cdd:cd15156  81 TNMYGSILFLTCISVDRFLAIVYPFR---SKTLRTKRNAKIVCAAV 123
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
46-139 7.24e-04

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 40.95  E-value: 7.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  46 IFGNLAMII--SISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCkiHYSFDLML--SITSIFH 121
Cdd:cd15142  15 VVGNLIAIVvlCKSRKEQKETTFYTLVCGLAVTDLLGTCLASPVTIATYLKGRWPGGQPLC--EYFSFILLffSLSGLSI 92
                        90
                ....*....|....*...
gi 56605936 122 LCSVAVDRFYAICHPLHY 139
Cdd:cd15142  93 ICAMSIERYLAINHAYFY 110
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
45-314 7.77e-04

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 40.66  E-value: 7.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  45 TIFGNLAMIISISYFKQLHT-PTNLLILSMAVTDfLLGFTIMPYSMV-------RSVENCWYFGLTFCKIHYSfdlmLSI 116
Cdd:cd15340  14 TVLENLLVLCVILHSRSLRCrPSYHFIGSLAVAD-LLGSVIFVYSFLdfhvfhrKDSPNVFLFKLGGVTASFT----ASV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 117 TSIFhlcSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseayadgieGYDIlVACSSSCPVMFNKL 196
Cdd:cd15340  89 GSLF---LTAIDRYISIHRPLAYKRIVTRTKAVIAFCVMWTIAIVIAVLPLL---------GWNC-KKLNSVCSDIFPLI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 197 WGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARVIDNLPENQN------------------NQMRKDKKAAKTLGIVMGV 258
Cdd:cd15340 156 DETYLMFWIGVTSVLLLFIVYAYMYILWKAHHHAVRMLQRGTQksiivytsedgkvqttrpDQTRMDIRLAKTLVLILVV 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 56605936 259 FLLCWFPCFFTILLDPFLNFS-TPAVLFDALTWFGYFNSTCNPLIYGFFYPWFRRAL 314
Cdd:cd15340 236 LIICWGPLLAIMVYDVFGKMNkLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-306 8.41e-04

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 40.57  E-value: 8.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLG-FTIMPySMVRSVENCWYFGLTFCKIHYSFDLML 114
Cdd:cd15387   5 TVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAvFQVLP-QLIWDITFRFYGPDFLCRLVKYLQVVG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPL---HYCTKMTIPVVRRLLLVCWSVPGAFAFGVvfsEAYADGIegYDilvacsssCPV 191
Cdd:cd15387  84 MFASTYMLLLMSIDRCLAICQPLrslHRRSDRVYVLFSWLLSLVFSIPQVHIFSL---REVGNGV--YD--------CWA 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 192 MFNKLWG-----TTLFVAGFFTPSSMMVGIYG----KIFAVSKKHARVIDNLPENQNNQMR---------------KDKK 247
Cdd:cd15387 151 DFIQPWGpkayiTWITLSVYIIPVLILSVCYGlisfKIWQNVKLKTRRETKTPLSSAASGGaalarvssvkliskaKIRT 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56605936 248 AAKTLGIVMGvFLLCWFPCFFTILL---DPflNFSTPAVLFDALTWFGYFNSTCNPLIYGFF 306
Cdd:cd15387 231 VKMTFVIVLA-YIVCWTPFFFVQMWsvwDP--NAPKEASPFIIAMLLASLNSCCNPWIYMFF 289
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-272 8.62e-04

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 40.61  E-value: 8.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLML 114
Cdd:cd15976   4 TVVSCLVFVLgIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKAS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSVAVDRFYAICHPLHYCTkMTIP-------VVRRLLLVCWSVPGAFAFGVVFSEaYADGIEGYDILVACSS 187
Cdd:cd15976  84 VGITVLSLCALSIDRYRAVASWSRIKG-IGVPkwtaveiVLIWVVSIILAVPEAIGFDMITMD-YKGELLRICLLHPIQK 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 188 SCPVMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFA---VSKKHARVIdnlpeNQNNQMRKDKKAAKTLGIVMGVFLLCWF 264
Cdd:cd15976 162 TAFMQFYKTAKDWWLFSFYFCLPLACTAVFYTLMTcemLRKKNGMQI-----ALNDHLKQRREVAKTVFCLVLVFALCWL 236

                ....*...
gi 56605936 265 PCFFTILL 272
Cdd:cd15976 237 PLHLSRIL 244
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
36-306 8.95e-04

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 40.57  E-value: 8.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLG-FTIMPysmvrsvENCW-----YFGLTF-CKIHY 108
Cdd:cd15385   5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAfFQVLP-------QLCWdityrFYGPDFlCRIVK 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 109 SFDLMLSITSIFHLCSVAVDRFYAICHPLhycTKMTIPVVRRLLLV--CW------SVPGAFAFGVVFSEayaDGIEGYD 180
Cdd:cd15385  78 HLQVLGMFASTYMLVMMTADRYIAICHPL---KTLQQPTKRSYLMIgsAWalsfilSTPQYFIFSLSEIE---NGSGVYD 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 181 ilvacsssCPVMFNKLWGTTLFVAG-----FFTPSSMMVGIYGKI-FAVSKK-HARVIDNLPENQNNQM----------- 242
Cdd:cd15385 152 --------CWANFIVPWGIKAYITWitisiFVVPVIILLTCYGFIcYNIWRNiKCKTRRGLSDNALKNIllavcvssvkt 223
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56605936 243 --RKDKKAAKTLGIVMGVFLLCWFPcFFTILL-------DPFLNFSTPAVLFDALtwFGYFNSTCNPLIYGFF 306
Cdd:cd15385 224 isRAKIRTVKMTFVIVLAYIVCWAP-FFTIQMwsvwdqnFPWDESENTAVTITAL--LASLNSCCNPWIYMFF 293
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
42-156 9.62e-04

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 40.24  E-value: 9.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  42 IFI-TIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVEN--CWY-FGLTFCKIHYSFDLMLSIT 117
Cdd:cd15006   9 IFVgSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLSASPhcCWWiYTLLFCKVIKFLHKVFCSV 88
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 56605936 118 SIFHLCSVAVDRFYAICHPLHycTKMTIPVVRRLLLVCW 156
Cdd:cd15006  89 TVLSFAAIALDRYYSVLYPLE--RKISDAKSRDLVIYIW 125
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
40-154 1.02e-03

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 40.14  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  40 CAIFI-TIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITS 118
Cdd:cd15955   8 CIMFLlAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFE 87
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 56605936 119 IFHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLV 154
Cdd:cd15955  88 SGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVL 123
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
37-312 1.32e-03

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 39.76  E-value: 1.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  37 LMACAIFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDflLGFTIMPYSMVRSVENCWYF--GLTFCKIHysfDLML 114
Cdd:cd15075   6 IMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVAD--LGTTVFGGLLSVVTNAVGYFnlGRVGCVLE---GFAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 115 SITSIFHLCSV---AVDRFYAICHPLHYCTKMTIPVVRRLLL-----VCWSVPGAFAFGvvfseAYAdgIEGydILVACS 186
Cdd:cd15075  81 AFFGIAALCTVaviAVDRLFVVCKPLGTLTFQTRHALAGIASswlwsLIWNTPPLFGWG-----SYQ--LEG--VMTSCA 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 187 ----SSCPVmfNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARvidnLPENQNNQMRKDKKAAKTLGIVM-GVFLL 261
Cdd:cd15075 152 pdwySRDPV--NVSYILCYFSFCFAIPFAIILVSYGYLLWTLRQVAK----LGVAEGGSTAKAEVQVARMVVVMvMAFLL 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 56605936 262 CWFP---CFFTILLDPFLNF-----STPAVLFDALTWFgyfnstcNPLIYGFFYPWFRR 312
Cdd:cd15075 226 CWLPyaaFALTVVSKPDVYInpliaTVPMYLAKSSTVY-------NPIIYIFMNKQFRD 277
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
42-264 1.41e-03

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 39.88  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936    42 IFITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPysmvrsvenCWYFGLTFCKIHYSFDLMLSITSIFH 121
Cdd:pfam10320   1 SVIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIV---------FVVLLFTGTQLTRNECFWMISFYIFG 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936   122 LC-------SVAVDRFYAICHPLHYctkMTIPVVRRLLLVCWSVPGAFAFGVVFSEAYADgiegYDILVACSsscpVMFn 194
Cdd:pfam10320  72 QTaqgplmlMIGIDRLIAVKFPIFY---RLLSSSKYLFIQLIFPVIYSSFITVYGFLQRD----DETIIVCA----PPL- 139
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936   195 klwGTTLFVAGFFTPSSmmVGIYGKIFAVSKKHARVIDNLPENQNNQMrkdKKAAKTLGIVMGVFLLCWF 264
Cdd:pfam10320 140 ---ALPGTAFTIFTLSS--LFINVIVLIVYIILIIIFKNKKQSQNSDS---KKVFKSLQVTVVIFIFGWF 201
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
59-265 1.49e-03

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 39.76  E-value: 1.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  59 FKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRFYAICHPLH 138
Cdd:cd15120  27 FKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVW 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 139 YCTKMTIPVVRRLLLVCWSVPGAFAFGVVfseAYADGIEGYDILVACSSSCPVMFNKL------WGTTLFVA-------- 204
Cdd:cd15120 107 SRQHRTNRWASAIVLGVWISAILLSIPYL---AFRETRLDEKGKTICQNNYALSTNWEsaevqaSRQWIHVAmfvfrfll 183
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56605936 205 GFFTPSSMMVGIYGKIfAVSKKHARvidnlpenqnnqMRKDKKAAKTLGIVMGVFLLCWFP 265
Cdd:cd15120 184 GFLLPFLIITFCYVRM-ALKMKERG------------LARSSKPFKVMFTAVVSFFVCWLP 231
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
35-311 1.52e-03

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 39.81  E-value: 1.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  35 YSLMACAIFITIFG---NLAMIISISYFKQLHTPTNLLILSMAVTDFLL---GFTIMPYSMVRSVencWYFGLTFCKIHY 108
Cdd:cd15077   1 MGMSAFMLFLVIAGfpiNVLTIICTIKYKKLRSHLNYILVNLAVANLIVvcfGSTTAFYSFSQMY---FVLGPLACKIEG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 109 SFDLMLSITSIFHLCSVAVDRFYAICHPL-HYCTKMTIPVVRRLLLVCW----SVPGAFAFGVVFSEAY--ADGIEGYDI 181
Cdd:cd15077  78 FTATLGGMVSLWSLAVVAFERFLVICKPLgNFTFRGTHAIIGCIATWVFglaaSLPPLFGWSRYIPEGLqcSCGPDWYTT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 182 LVACSSSCPVMFnklwgttLFVAGFFTPSSMMVGIYGKIFAVSKKHARVidnlPENQNNQMRKDKKAAKTLGIVMGVFLL 261
Cdd:cd15077 158 NNKWNNESYVMF-------LFCFCFGVPLSIIVFSYGRLLLTLRAVAKQ----QEQSASTQKAEREVTKMVVVMVLGFLV 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 56605936 262 CWFP-CFFTILL-----DPF-LNFST-PAVLFDALTWFgyfnstcNPLIYGFFYPWFR 311
Cdd:cd15077 227 CWLPyASFALWVvtnrgEPFdLRLASiPSVFSKASTVY-------NPVIYVFMNKQFR 277
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
51-327 1.68e-03

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 39.73  E-value: 1.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  51 AMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVDRF 130
Cdd:cd15119  19 AIVIWVTGFKWKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVAVLNMFASVLFLTVISLDRY 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 131 YAICHPLHYCTKMTIPVVRRLLLVCWSVPGAFAFGVVFseaYADGIEGYDILVAC-------SSSCPVMFNKLWGTTLFV 203
Cdd:cd15119  99 ISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALY---FRDTMELSINVTICfnnfhkhDGDLIVMRHTILVWVRFF 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 204 AGFFTPSSMMVgIYGKIFAVSKKHARVIDNlpenqnnqmrkdKKAAKTLGIVMGVFLLCWFPCFFTILLDpfLNFSTPAV 283
Cdd:cd15119 176 FGFLFPLLTMV-VCYSLLAIKVKRRTLLIS------------SKFFWTISAVIVAFFVCWTPYHIFSILE--LSIHHSSY 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 56605936 284 LFDAL-------TWFGYFNSTCNPLIygffypwfrralkYILLGKIFSSHF 327
Cdd:cd15119 241 LHNVLragiplaTSLAFINSCLNPIL-------------YVLIGKKFKAHL 278
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
44-156 1.86e-03

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 39.45  E-value: 1.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHT-PTNLLILSMAVTDFLLGFTIMPYSMVRSVENCwYFGLTF--CKIH-YSFDLMLSiTSI 119
Cdd:cd15941  13 LTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLS-GRTISFegCVVQlYAFHFLAS-TEC 90
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 56605936 120 FHLCSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15941  91 FLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTW 127
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
49-272 1.93e-03

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 39.24  E-value: 1.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  49 NLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTiMPYSMVRSVENcWYFGLTFCKIHYSFDLMLSITSIFHLCSVAVD 128
Cdd:cd15165  18 NLMALWVFLFKIKKWTESTIYMINLALNDLLLLLS-LPFKMHSSKKQ-WPLGRTLCSFLESLYFVNMYGSILIIVCISVD 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 129 RFYAICHPLhycTKMTIPVVRRLLLVCwsvpgAFAFGVVFseayADGIEGYDI--LVACSSSCPVMF-NKLWGTTLFVA- 204
Cdd:cd15165  96 RYIAIRHPF---LAKRLRSPRKAAIVC-----LTIWVFVW----AGSIPIYSFhdKPTNNTRCFHGFsNKTWSKKVIVVv 163
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56605936 205 ---GFFTPSSMMVGIYGKIFAVSKKHARvidnlpenQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILL 272
Cdd:cd15165 164 eefGFLIPMAVMVFCSVQIIRTLLDMRR--------PEQPKVKQNKSVKIVLSNLVVFLVCFTPYHLGIFL 226
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
43-156 2.09e-03

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 39.34  E-value: 2.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  43 FITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHL 122
Cdd:cd15228  12 LCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLLY 91
                        90       100       110
                ....*....|....*....|....*....|....
gi 56605936 123 CSVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15228  92 TVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTW 125
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
35-132 2.85e-03

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 39.07  E-value: 2.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  35 YSLMACAIFI---TIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15127   1 YAVMCLSVVIfgiGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIE 80
                        90       100
                ....*....|....*....|.
gi 56605936 112 LMLSITSIFHLCSVAVDRFYA 132
Cdd:cd15127  81 VASLGVTTFTLCALCIDRFRA 101
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
35-137 2.91e-03

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 38.98  E-value: 2.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  35 YSLMACAIFITI---FGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFD 111
Cdd:cd15398   1 YFLIGLYTFISLlgfLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQ 80
                        90       100
                ....*....|....*....|....*.
gi 56605936 112 LMLSITSIFHLCSVAVDRFYAICHPL 137
Cdd:cd15398  81 CVSVMVSTLMLMSIAIVRYHMIKHPL 106
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
36-272 3.90e-03

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 38.69  E-value: 3.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  36 SLMACAIFIT-IFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYF-----GLTFCKIHYS 109
Cdd:cd15975   4 TVLSCIIFIVgMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFddssfGVFLCKLVPF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 110 FDLMLSITSIFHLCSVAVDRFYAIChPLHYCTKMTIPVVRR-------LLLVCWSVPGAFAFGVVFSEaYADgiEGYDIL 182
Cdd:cd15975  84 LQKASVGITVLNLCALSVDRYRAVA-SWSRVQGIGIPLITAieifsiwVLSFILAIPEAIGFVMVPFE-YNG--EQYRTC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936 183 VACSSSCPVMFNKLWGTTLFVAGFFTPSSMMVGIYGKIFAVSKKHARViDNLPENQNNQMRKDKKAAKTLGIVMGVFLLC 262
Cdd:cd15975 160 MLNATTKFMNFYVDAKDWWLFGFYFCVPLACTAIFYTLMTCEMLNRRK-GSLRIALSEHLKQRREVAKTVFCLVVIFALC 238
                       250
                ....*....|
gi 56605936 263 WFPCFFTILL 272
Cdd:cd15975 239 WFPLHLSRIL 248
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
44-156 7.92e-03

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 37.46  E-value: 7.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15433  13 LTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVLLA 92
                        90       100       110
                ....*....|....*....|....*....|...
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCW 156
Cdd:cd15433  93 VMAFDRYAAVCRPLHYAALMSPRLCQTLASISW 125
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
44-161 8.39e-03

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 37.35  E-value: 8.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605936  44 ITIFGNLAMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLTFCKIHYSFDLMLSITSIFHLC 123
Cdd:cd15430  13 VILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVLLA 92
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 56605936 124 SVAVDRFYAICHPLHYCTKMTIPVVRRLLLVCWSVPGA 161
Cdd:cd15430  93 VMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFL 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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