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Conserved domains on  [gi|281371335|ref|NP_001006989|]
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tRNA (34-2'-O)-methyltransferase regulator WDR6 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822067)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 206-325 2.58e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 80.84  E-value: 2.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  206 SGHVGVIFSMSYLESKGLLATASEDRSVRIWkvgDLRVPggrvQNIGHCFGHSARVWQVKLLEN--YLISAGEDCVCLVW 283
Cdd:cd00200   174 TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW---DLSTG----KCLGTLRGHENGVNSVAFSPDgyLLASGSEDGTIRVW 246

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 281371335  284 SHE-GEILQAFRGHQGRgIRAIAAHERQTWVITGGDDSGIRLW 325
Cdd:cd00200   247 DLRtGECVQTLSGHTNS-VTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
190-517 6.92e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 6.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  190 ATALPDNKPVAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWkvgdlRVPGGRVQNIGHcfGHSARVWQVKLLEN 269
Cdd:COG2319    59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW-----DLATGLLLRTLT--GHTGAVRSVAFSPD 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  270 --YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQTWVITGGDDSGIRLWHLVG-------RGYPGlGVSS 339
Cdd:COG2319   132 gkTLASGSADGTVRLWDlATGKLLRTLTGHSGA-VTSVAFSPDGKLLASGSDDGTVRLWDLATgkllrtlTGHTG-AVRS 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  340 LSFkSPSRpgalkavtlagswRVLAVTDVGG-LYLYDLEVKCWEQLLEDNRFQSYCLleaAPGPEGfGLCALANGEGLVK 418
Cdd:COG2319   210 VAF-SPDG-------------KLLASGSADGtVRLWDLATGKLLRTLTGHSGSVRSV---AFSPDG-RLLASGSADGTVR 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  419 VVPINTPTAAVDQNLFQGKVHSLSWALRGyeELLLLASGPGGVvaclEISAAPTGKAIFVkercryllPPSKQRWHTCSA 498
Cdd:COG2319   272 LWDLATGELLRTLTGHSGGVNSVAFSPDG--KLLASGSDDGTV----RLWDLATGKLLRT--------LTGHTGAVRSVA 337

                         330
                  ....*....|....*....
gi 281371335  499 FLPPGDFLVCGDRRGSVLL 517
Cdd:COG2319   338 FSPDGKTLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
880-1083 1.11e-07

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  880 GPLVAAACSDGAVRLFLLqDSGRILHLLAetfHHKRCVLKVhSFTheaPNQRRrliLCSAATDGSIAFWDLTTamdrgst 959
Cdd:COG2319   216 GKLLASGSADGTVRLWDL-ATGKLLRTLT---GHSGSVRSV-AFS---PDGRL---LASGSADGTVRLWDLAT------- 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  960 tleppahpglpyqmGTPCLTVQAHSCGVNSLHTlpTPEGHHLvASGSEDGSLHVFTLAvkmpeleeaDGEaelvpQLCVL 1039
Cdd:COG2319   278 --------------GELLRTLTGHSGGVNSVAF--SPDGKLL-ASGSDDGTVRLWDLA---------TGK-----LLRTL 326

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 281371335 1040 DeysvpcAHAAHVTGIKIlSP--KLMVSASIDQRLTFWRLGNGEPT 1083
Cdd:COG2319   327 T------GHTGAVRSVAF-SPdgKTLASGSDDGTVRLWDLATGELL 365
WD40 super family cl43672
WD40 repeat [General function prediction only];
563-952 8.85e-03

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 8.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  563 LHSLHGKQG-VTSVTCH--GGYVYSTGRDGSYyQLF-VHGGRLQPVLRQKAcrgmNWIAGLRMAPDGSMVVLGFHANEFV 638
Cdd:COG2319   113 LRTLTGHTGaVRSVAFSpdGKTLASGSADGTV-RLWdLATGKLLRTLTGHS----GAVTSVAFSPDGKLLASGSDDGTVR 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  639 VWSPRSHEKLHIVNcggGHRSW----AFSDTEAAMAFAyLKDGDVMLYRALGGcirpNVILREGLHGREITCVkrvgtvt 714
Cdd:COG2319   188 LWDLATGKLLRTLT---GHTGAvrsvAFSPDGKLLASG-SADGTVRLWDLATG----KLLRTLTGHSGSVRSV------- 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  715 lgpEFevpnleHPDSlepgsegpgliDIVITGSEDTTVCVLALPTTTgAAHALTAvcnHISSVRALAVwgvgTPGGpqds 794
Cdd:COG2319   253 ---AF------SPDG-----------RLLASGSADGTVRLWDLATGE-LLRTLTG---HSGGVNSVAF----SPDG---- 300

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  795 hpgltAQVVSAGGRAEMHCFslmitpDASTPSRLACHIMHLSSHRldeywdrqrnrhrmikvdpetrymSLAIcelDSDr 874
Cdd:COG2319   301 -----KLLASGSDDGTVRLW------DLATGKLLRTLTGHTGAVR------------------------SVAF---SPD- 341

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281371335  875 pglgpGPLVAAACSDGAVRLFLLqDSGRILHLLAEtfhHKRCVLKVhSFTheaPNQRRrliLCSAATDGSIAFWDLTT 952
Cdd:COG2319   342 -----GKTLASGSDDGTVRLWDL-ATGELLRTLTG---HTGAVTSV-AFS---PDGRT---LASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 206-325 2.58e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.84  E-value: 2.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  206 SGHVGVIFSMSYLESKGLLATASEDRSVRIWkvgDLRVPggrvQNIGHCFGHSARVWQVKLLEN--YLISAGEDCVCLVW 283
Cdd:cd00200   174 TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW---DLSTG----KCLGTLRGHENGVNSVAFSPDgyLLASGSEDGTIRVW 246

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 281371335  284 SHE-GEILQAFRGHQGRgIRAIAAHERQTWVITGGDDSGIRLW 325
Cdd:cd00200   247 DLRtGECVQTLSGHTNS-VTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
174-345 3.68e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.72  E-value: 3.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  174 TIVAGAVSNELLVWYPATalpdNKPVapdRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWkvgdlRVPGGRVQNIGH 253
Cdd:COG2319   218 LLASGSADGTVRLWDLAT----GKLL---RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW-----DLATGELLRTLT 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  254 cfGHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQTWVITGGDDSGIRLWHLVG- 329
Cdd:COG2319   286 --GHSGGVNSVAFSPDgkLLASGSDDGTVRLWDlATGKLLRTLTGHTGA-VRSVAFSPDGKTLASGSDDGTVRLWDLATg 362

                         170       180
                  ....*....|....*....|..
gi 281371335  330 ------RGYPGlGVSSLSFkSP 345
Cdd:COG2319   363 ellrtlTGHTG-AVTSVAF-SP 382
WD40 COG2319
WD40 repeat [General function prediction only];
190-517 6.92e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 6.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  190 ATALPDNKPVAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWkvgdlRVPGGRVQNIGHcfGHSARVWQVKLLEN 269
Cdd:COG2319    59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW-----DLATGLLLRTLT--GHTGAVRSVAFSPD 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  270 --YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQTWVITGGDDSGIRLWHLVG-------RGYPGlGVSS 339
Cdd:COG2319   132 gkTLASGSADGTVRLWDlATGKLLRTLTGHSGA-VTSVAFSPDGKLLASGSDDGTVRLWDLATgkllrtlTGHTG-AVRS 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  340 LSFkSPSRpgalkavtlagswRVLAVTDVGG-LYLYDLEVKCWEQLLEDNRFQSYCLleaAPGPEGfGLCALANGEGLVK 418
Cdd:COG2319   210 VAF-SPDG-------------KLLASGSADGtVRLWDLATGKLLRTLTGHSGSVRSV---AFSPDG-RLLASGSADGTVR 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  419 VVPINTPTAAVDQNLFQGKVHSLSWALRGyeELLLLASGPGGVvaclEISAAPTGKAIFVkercryllPPSKQRWHTCSA 498
Cdd:COG2319   272 LWDLATGELLRTLTGHSGGVNSVAFSPDG--KLLASGSDDGTV----RLWDLATGKLLRT--------LTGHTGAVRSVA 337

                         330
                  ....*....|....*....
gi 281371335  499 FLPPGDFLVCGDRRGSVLL 517
Cdd:COG2319   338 FSPDGKTLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
880-1083 1.11e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  880 GPLVAAACSDGAVRLFLLqDSGRILHLLAetfHHKRCVLKVhSFTheaPNQRRrliLCSAATDGSIAFWDLTTamdrgst 959
Cdd:COG2319   216 GKLLASGSADGTVRLWDL-ATGKLLRTLT---GHSGSVRSV-AFS---PDGRL---LASGSADGTVRLWDLAT------- 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  960 tleppahpglpyqmGTPCLTVQAHSCGVNSLHTlpTPEGHHLvASGSEDGSLHVFTLAvkmpeleeaDGEaelvpQLCVL 1039
Cdd:COG2319   278 --------------GELLRTLTGHSGGVNSVAF--SPDGKLL-ASGSDDGTVRLWDLA---------TGK-----LLRTL 326

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 281371335 1040 DeysvpcAHAAHVTGIKIlSP--KLMVSASIDQRLTFWRLGNGEPT 1083
Cdd:COG2319   327 T------GHTGAVRSVAF-SPdgKTLASGSDDGTVRLWDLATGELL 365
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 878-1014 9.76e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 9.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  878 GPGPLVAAACSDGAVRLFLLqDSGRILHLLAetfHHKRCVLKVhSFTheaPNQRRrliLCSAATDGSIAFWDLTTamdrg 957
Cdd:cd00200   145 PDGTFVASSSQDGTIKLWDL-RTGKCVATLT---GHTGEVNSV-AFS---PDGEK---LLSSSSDGTIKLWDLST----- 208

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 281371335  958 sttleppahpglpyqmGTPCLTVQAHSCGVNSLHTLPTpegHHLVASGSEDGSLHVF 1014
Cdd:cd00200   209 ----------------GKCLGTLRGHENGVNSVAFSPD---GYLLASGSEDGTIRVW 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 201-237 1.10e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 1.10e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 281371335    201 PDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWK 237
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
287-325 1.26e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.26e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 281371335   287 GEILQAFRGHQGrGIRAIAAHERQTWVITGGDDSGIRLW 325
Cdd:pfam00400    1 GKLLKTLEGHTG-SVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
563-952 8.85e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 8.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  563 LHSLHGKQG-VTSVTCH--GGYVYSTGRDGSYyQLF-VHGGRLQPVLRQKAcrgmNWIAGLRMAPDGSMVVLGFHANEFV 638
Cdd:COG2319   113 LRTLTGHTGaVRSVAFSpdGKTLASGSADGTV-RLWdLATGKLLRTLTGHS----GAVTSVAFSPDGKLLASGSDDGTVR 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  639 VWSPRSHEKLHIVNcggGHRSW----AFSDTEAAMAFAyLKDGDVMLYRALGGcirpNVILREGLHGREITCVkrvgtvt 714
Cdd:COG2319   188 LWDLATGKLLRTLT---GHTGAvrsvAFSPDGKLLASG-SADGTVRLWDLATG----KLLRTLTGHSGSVRSV------- 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  715 lgpEFevpnleHPDSlepgsegpgliDIVITGSEDTTVCVLALPTTTgAAHALTAvcnHISSVRALAVwgvgTPGGpqds 794
Cdd:COG2319   253 ---AF------SPDG-----------RLLASGSADGTVRLWDLATGE-LLRTLTG---HSGGVNSVAF----SPDG---- 300

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  795 hpgltAQVVSAGGRAEMHCFslmitpDASTPSRLACHIMHLSSHRldeywdrqrnrhrmikvdpetrymSLAIcelDSDr 874
Cdd:COG2319   301 -----KLLASGSDDGTVRLW------DLATGKLLRTLTGHTGAVR------------------------SVAF---SPD- 341

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281371335  875 pglgpGPLVAAACSDGAVRLFLLqDSGRILHLLAEtfhHKRCVLKVhSFTheaPNQRRrliLCSAATDGSIAFWDLTT 952
Cdd:COG2319   342 -----GKTLASGSDDGTVRLWDL-ATGELLRTLTG---HTGAVTSV-AFS---PDGRT---LASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 206-325 2.58e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.84  E-value: 2.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  206 SGHVGVIFSMSYLESKGLLATASEDRSVRIWkvgDLRVPggrvQNIGHCFGHSARVWQVKLLEN--YLISAGEDCVCLVW 283
Cdd:cd00200   174 TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW---DLSTG----KCLGTLRGHENGVNSVAFSPDgyLLASGSEDGTIRVW 246

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 281371335  284 SHE-GEILQAFRGHQGRgIRAIAAHERQTWVITGGDDSGIRLW 325
Cdd:cd00200   247 DLRtGECVQTLSGHTNS-VTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
174-345 3.68e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.72  E-value: 3.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  174 TIVAGAVSNELLVWYPATalpdNKPVapdRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWkvgdlRVPGGRVQNIGH 253
Cdd:COG2319   218 LLASGSADGTVRLWDLAT----GKLL---RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW-----DLATGELLRTLT 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  254 cfGHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQTWVITGGDDSGIRLWHLVG- 329
Cdd:COG2319   286 --GHSGGVNSVAFSPDgkLLASGSDDGTVRLWDlATGKLLRTLTGHTGA-VRSVAFSPDGKTLASGSDDGTVRLWDLATg 362

                         170       180
                  ....*....|....*....|..
gi 281371335  330 ------RGYPGlGVSSLSFkSP 345
Cdd:COG2319   363 ellrtlTGHTG-AVTSVAF-SP 382
WD40 COG2319
WD40 repeat [General function prediction only];
174-327 3.78e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.72  E-value: 3.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  174 TIVAGAVSNELLVWYPATAlpdnkpvAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVqnigh 253
Cdd:COG2319   260 LLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT----- 327

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281371335  254 cfGHSARVWQVKL--LENYLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQTWVITGGDDSGIRLWHL 327
Cdd:COG2319   328 --GHTGAVRSVAFspDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGA-VTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 203-327 5.15e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 5.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  203 RRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVqnighcfGHSARVWQVKLL--ENYLISAGEDCVC 280
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-------GHTGPVRDVAASadGTYLASGSSDKTI 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 281371335  281 LVWS-HEGEILQAFRGHQGrGIRAIAAHERQTWVITGGDDSGIRLWHL 327
Cdd:cd00200    76 RLWDlETGECVRTLTGHTS-YVSSVAFSPDGRILSSSSRDKTIKVWDV 122
WD40 COG2319
WD40 repeat [General function prediction only];
174-345 3.69e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 3.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  174 TIVAGAVSNELLVWYPATAlpdnkpvAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWKVGDlrvpGGRVQNIGh 253
Cdd:COG2319   176 LLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT----GKLLRTLT- 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  254 cfGHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQTWVITGGDDSGIRLWHL--- 327
Cdd:COG2319   244 --GHSGSVRSVAFSPDgrLLASGSADGTVRLWDlATGELLRTLTGHSGG-VNSVAFSPDGKLLASGSDDGTVRLWDLatg 320

                         170       180
                  ....*....|....*....|.
gi 281371335  328 -VGRGYPG--LGVSSLSFkSP 345
Cdd:COG2319   321 kLLRTLTGhtGAVRSVAF-SP 340
WD40 COG2319
WD40 repeat [General function prediction only];
190-517 6.92e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 6.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  190 ATALPDNKPVAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWkvgdlRVPGGRVQNIGHcfGHSARVWQVKLLEN 269
Cdd:COG2319    59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW-----DLATGLLLRTLT--GHTGAVRSVAFSPD 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  270 --YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQTWVITGGDDSGIRLWHLVG-------RGYPGlGVSS 339
Cdd:COG2319   132 gkTLASGSADGTVRLWDlATGKLLRTLTGHSGA-VTSVAFSPDGKLLASGSDDGTVRLWDLATgkllrtlTGHTG-AVRS 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  340 LSFkSPSRpgalkavtlagswRVLAVTDVGG-LYLYDLEVKCWEQLLEDNRFQSYCLleaAPGPEGfGLCALANGEGLVK 418
Cdd:COG2319   210 VAF-SPDG-------------KLLASGSADGtVRLWDLATGKLLRTLTGHSGSVRSV---AFSPDG-RLLASGSADGTVR 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  419 VVPINTPTAAVDQNLFQGKVHSLSWALRGyeELLLLASGPGGVvaclEISAAPTGKAIFVkercryllPPSKQRWHTCSA 498
Cdd:COG2319   272 LWDLATGELLRTLTGHSGGVNSVAFSPDG--KLLASGSDDGTV----RLWDLATGKLLRT--------LTGHTGAVRSVA 337

                         330
                  ....*....|....*....
gi 281371335  499 FLPPGDFLVCGDRRGSVLL 517
Cdd:COG2319   338 FSPDGKTLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
880-1083 1.11e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  880 GPLVAAACSDGAVRLFLLqDSGRILHLLAetfHHKRCVLKVhSFTheaPNQRRrliLCSAATDGSIAFWDLTTamdrgst 959
Cdd:COG2319   216 GKLLASGSADGTVRLWDL-ATGKLLRTLT---GHSGSVRSV-AFS---PDGRL---LASGSADGTVRLWDLAT------- 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  960 tleppahpglpyqmGTPCLTVQAHSCGVNSLHTlpTPEGHHLvASGSEDGSLHVFTLAvkmpeleeaDGEaelvpQLCVL 1039
Cdd:COG2319   278 --------------GELLRTLTGHSGGVNSVAF--SPDGKLL-ASGSDDGTVRLWDLA---------TGK-----LLRTL 326

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 281371335 1040 DeysvpcAHAAHVTGIKIlSP--KLMVSASIDQRLTFWRLGNGEPT 1083
Cdd:COG2319   327 T------GHTGAVRSVAF-SPdgKTLASGSDDGTVRLWDLATGELL 365
WD40 COG2319
WD40 repeat [General function prediction only];
880-1082 3.84e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 3.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  880 GPLVAAACSDGAVRLFLLqDSGRILHLLAetfHHKRCVLKVhSFtheAPNQRRrliLCSAATDGSIAFWDLTTamdrgst 959
Cdd:COG2319   174 GKLLASGSDDGTVRLWDL-ATGKLLRTLT---GHTGAVRSV-AF---SPDGKL---LASGSADGTVRLWDLAT------- 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  960 tleppahpglpyqmGTPCLTVQAHSCGVNSLHTlpTPEGHHLvASGSEDGSLHVFTLAvkmpeleeaDGEaelvpQLCVL 1039
Cdd:COG2319   236 --------------GKLLRTLTGHSGSVRSVAF--SPDGRLL-ASGSADGTVRLWDLA---------TGE-----LLRTL 284

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 281371335 1040 DeysvpcAHAAHVTGIKIlSP--KLMVSASIDQRLTFWRLGNGEP 1082
Cdd:COG2319   285 T------GHSGGVNSVAF-SPdgKLLASGSDDGTVRLWDLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
880-1077 9.33e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 9.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  880 GPLVAAACSDGAVRLFLLqDSGRILHLLAetfHHKRCVLKVhSFTheaPNQRRrliLCSAATDGSIAFWDLTTamdrgst 959
Cdd:COG2319   258 GRLLASGSADGTVRLWDL-ATGELLRTLT---GHSGGVNSV-AFS---PDGKL---LASGSDDGTVRLWDLAT------- 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  960 tleppahpglpyqmGTPCLTVQAHSCGVNSLHTlpTPEGHHLvASGSEDGSLHVFTLAvkmpeleeaDGEaelvpQLCVL 1039
Cdd:COG2319   320 --------------GKLLRTLTGHTGAVRSVAF--SPDGKTL-ASGSDDGTVRLWDLA---------TGE-----LLRTL 368

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 281371335 1040 DeysvpcAHAAHVTGIKIlSP--KLMVSASIDQRLTFWRL 1077
Cdd:COG2319   369 T------GHTGAVTSVAF-SPdgRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
190-644 2.72e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.07  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  190 ATALPDNKPVAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVqnighcfGHSARVWQVKLLEN 269
Cdd:COG2319    17 ALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL-------GHTAAVLSVAFSPD 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  270 --YLISAGEDCVCLVWSHE-GEILQAFRGHQGRgIRAIAAHERQTWVITGGDDSGIRLWHLVG-------RGYPGlGVSS 339
Cdd:COG2319    90 grLLASASADGTVRLWDLAtGLLLRTLTGHTGA-VRSVAFSPDGKTLASGSADGTVRLWDLATgkllrtlTGHSG-AVTS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  340 LSFkSPSrpgalkavtlaGSWRVLAVTDvGGLYLYDLEVKCWEQLLEDNRFQSYCLleaAPGPEGFGLcALANGEGLVKV 419
Cdd:COG2319   168 VAF-SPD-----------GKLLASGSDD-GTVRLWDLATGKLLRTLTGHTGAVRSV---AFSPDGKLL-ASGSADGTVRL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  420 VPINTPTAAVDQNLFQGKVHSLSWALRGyeELLLLASGPGGVvaclEISAAPTGKAIFvkercrylLPPSKQRWHTCSAF 499
Cdd:COG2319   231 WDLATGKLLRTLTGHSGSVRSVAFSPDG--RLLASGSADGTV----RLWDLATGELLR--------TLTGHSGGVNSVAF 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  500 LPPGDFLVCGDRRGSVLLFPARpclfkkpgvgpkaitaaeapqagsssggsesvvTGlgpvSSLHSLHGKQG-VTSVTCH 578
Cdd:COG2319   297 SPDGKLLASGSDDGTVRLWDLA---------------------------------TG----KLLRTLTGHTGaVRSVAFS 339

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281371335  579 --GGYVYSTGRDGSYYQLFVHGGRLQPVLRQKAcrgmNWIAGLRMAPDGSMVVLGFHANEFVVWSPRS 644
Cdd:COG2319   340 pdGKTLASGSDDGTVRLWDLATGELLRTLTGHT----GAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 119-284 3.19e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 3.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  119 IWDARWLEGnVALALGHNSVVlydpvigcmlqdvpctdrctlSSACLIGDtwkELTIVAGAVSNELLVWypatalpDNKP 198
Cdd:cd00200   161 LWDLRTGKC-VATLTGHTGEV---------------------NSVAFSPD---GEKLLSSSSDGTIKLW-------DLST 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  199 VAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWKVGDLRVpggrvqnIGHCFGHSARVWQVKLLE--NYLISAGE 276
Cdd:cd00200   209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC-------VQTLSGHTNSVTSLAWSPdgKRLASGSA 281


                  ....*...
gi 281371335  277 DCVCLVWS 284
Cdd:cd00200   282 DGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 878-1014 9.76e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 9.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  878 GPGPLVAAACSDGAVRLFLLqDSGRILHLLAetfHHKRCVLKVhSFTheaPNQRRrliLCSAATDGSIAFWDLTTamdrg 957
Cdd:cd00200   145 PDGTFVASSSQDGTIKLWDL-RTGKCVATLT---GHTGEVNSV-AFS---PDGEK---LLSSSSDGTIKLWDLST----- 208

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 281371335  958 sttleppahpglpyqmGTPCLTVQAHSCGVNSLHTLPTpegHHLVASGSEDGSLHVF 1014
Cdd:cd00200   209 ----------------GKCLGTLRGHENGVNSVAFSPD---GYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 880-1014 1.30e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  880 GPLVAAACSDGAVRLFLLqDSGRILHLLAEtfhHKRCVLKVHSFTHeapnqrrRLILCSAATDGSIAFWDLTTamdrgst 959
Cdd:cd00200   189 GEKLLSSSSDGTIKLWDL-STGKCLGTLRG---HENGVNSVAFSPD-------GYLLASGSEDGTIRVWDLRT------- 250

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 281371335  960 tleppahpglpyqmGTPCLTVQAHSCGVNSLHTLPTPeghHLVASGSEDGSLHVF 1014
Cdd:cd00200   251 --------------GECVQTLSGHTNSVTSLAWSPDG---KRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 880-1014 5.86e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 5.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  880 GPLVAAACSDGAVRLFLLQdSGRILHllaeTFH-HKRCVLKVHsFTHEapnqrrRLILCSAATDGSIAFWDLTTamdrgs 958
Cdd:cd00200    63 GTYLASGSSDKTIRLWDLE-TGECVR----TLTgHTSYVSSVA-FSPD------GRILSSSSRDKTIKVWDVET------ 124

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 281371335  959 ttleppahpglpyqmGTPCLTVQAHSCGVNSLHTLPTpegHHLVASGSEDGSLHVF 1014
Cdd:cd00200   125 ---------------GKCLTTLRGHTDWVNSVAFSPD---GTFVASSSQDGTIKLW 162
WD40 COG2319
WD40 repeat [General function prediction only];
874-1082 9.37e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 9.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  874 RPGLGPGPLVAAACSDGAVRLFLLQDSGRILHLLAETFHHKRCVLKVHSFTHEAPNQRRRLILCSAATDGSIAFWDLTTa 953
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT- 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  954 mdrgsttleppahpglpyqmGTPCLTVQAHSCGVNSLHTlpTPEGHHLvASGSEDGSLHVFTLavkmpeleeADGEaelv 1033
Cdd:COG2319   110 --------------------GLLLRTLTGHTGAVRSVAF--SPDGKTL-ASGSADGTVRLWDL---------ATGK---- 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 281371335 1034 pQLCVLDeysvpcAHAAHVTGIKIlSP--KLMVSASIDQRLTFWRLGNGEP 1082
Cdd:COG2319   154 -LLRTLT------GHSGAVTSVAF-SPdgKLLASGSDDGTVRLWDLATGKL 196
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 201-237 1.10e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 1.10e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 281371335    201 PDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWK 237
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
287-325 1.26e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.26e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 281371335   287 GEILQAFRGHQGrGIRAIAAHERQTWVITGGDDSGIRLW 325
Cdd:pfam00400    1 GKLLKTLEGHTG-SVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 935-1092 1.40e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.94  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  935 ILCSAATDGSIAFWDLTTamDRGSTTLEPPAHPGL-----------------------PYQMGTPCLTVQAHSCGVNSLH 991
Cdd:cd00200    23 LLATGSGDGTIKVWDLET--GELLRTLKGHTGPVRdvaasadgtylasgssdktirlwDLETGECVRTLTGHTSYVSSVA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  992 TLPTpegHHLVASGSEDGSLHVFTLavkmpeleeADGEAELVPQlcvldeysvpcAHAAHVTGIKILSPKLMV-SASIDQ 1070
Cdd:cd00200   101 FSPD---GRILSSSSRDKTIKVWDV---------ETGKCLTTLR-----------GHTDWVNSVAFSPDGTFVaSSSQDG 157

                         170       180
                  ....*....|....*....|....*.
gi 281371335 1071 RLTFWRLGNGEP----TFMNSTVYHV 1092
Cdd:cd00200   158 TIKLWDLRTGKCvatlTGHTGEVNSV 183
WD40 COG2319
WD40 repeat [General function prediction only];
174-240 4.21e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.05  E-value: 4.21e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281371335  174 TIVAGAVSNELLVWYPATAlpdnkpvAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWKVGD 240
Cdd:COG2319   344 TLASGSDDGTVRLWDLATG-------ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 287-326 4.56e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 4.56e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 281371335    287 GEILQAFRGHQGRgIRAIAAHERQTWVITGGDDSGIRLWH 326
Cdd:smart00320    2 GELLKTLKGHTGP-VTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
203-236 7.28e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 7.28e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 281371335   203 RRVSGHVGVIFSMSYLESKGLLATASEDRSVRIW 236
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
563-952 8.85e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 8.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  563 LHSLHGKQG-VTSVTCH--GGYVYSTGRDGSYyQLF-VHGGRLQPVLRQKAcrgmNWIAGLRMAPDGSMVVLGFHANEFV 638
Cdd:COG2319   113 LRTLTGHTGaVRSVAFSpdGKTLASGSADGTV-RLWdLATGKLLRTLTGHS----GAVTSVAFSPDGKLLASGSDDGTVR 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  639 VWSPRSHEKLHIVNcggGHRSW----AFSDTEAAMAFAyLKDGDVMLYRALGGcirpNVILREGLHGREITCVkrvgtvt 714
Cdd:COG2319   188 LWDLATGKLLRTLT---GHTGAvrsvAFSPDGKLLASG-SADGTVRLWDLATG----KLLRTLTGHSGSVRSV------- 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  715 lgpEFevpnleHPDSlepgsegpgliDIVITGSEDTTVCVLALPTTTgAAHALTAvcnHISSVRALAVwgvgTPGGpqds 794
Cdd:COG2319   253 ---AF------SPDG-----------RLLASGSADGTVRLWDLATGE-LLRTLTG---HSGGVNSVAF----SPDG---- 300

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371335  795 hpgltAQVVSAGGRAEMHCFslmitpDASTPSRLACHIMHLSSHRldeywdrqrnrhrmikvdpetrymSLAIcelDSDr 874
Cdd:COG2319   301 -----KLLASGSDDGTVRLW------DLATGKLLRTLTGHTGAVR------------------------SVAF---SPD- 341

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281371335  875 pglgpGPLVAAACSDGAVRLFLLqDSGRILHLLAEtfhHKRCVLKVhSFTheaPNQRRrliLCSAATDGSIAFWDLTT 952
Cdd:COG2319   342 -----GKTLASGSDDGTVRLWDL-ATGELLRTLTG---HTGAVTSV-AFS---PDGRT---LASGSADGTVRLWDLAT 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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