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Conserved domains on  [gi|55741780|ref|NP_001006988|]
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maspardin isoform 3 [Rattus norvegicus]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 45-139 1.07e-11

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 62.71  E-value: 1.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741780  45 PLIFLPPVSGTADVFFQQILALTGwGYRVIALQYPVY---------WDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLA 115
Cdd:COG0596  25 PVVLLHGLPGSSYEWRPLIPALAA-GYRVIAPDLRGHgrsdkpaggYTLDDLADDLAALLDALGLERVVLVGHSMGGMVA 103

                        90       100
                ....*....|....*....|....
gi 55741780 116 QKFAEytHKSPRVHSLILCNAFSD 139
Cdd:COG0596 104 LELAA--RHPERVAGLVLVDEVLA 125
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 45-139 1.07e-11

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 62.71  E-value: 1.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741780  45 PLIFLPPVSGTADVFFQQILALTGwGYRVIALQYPVY---------WDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLA 115
Cdd:COG0596  25 PVVLLHGLPGSSYEWRPLIPALAA-GYRVIAPDLRGHgrsdkpaggYTLDDLADDLAALLDALGLERVVLVGHSMGGMVA 103

                        90       100
                ....*....|....*....|....
gi 55741780 116 QKFAEytHKSPRVHSLILCNAFSD 139
Cdd:COG0596 104 LELAA--RHPERVAGLVLVDEVLA 125
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 45-147 1.01e-08

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 54.43  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741780    45 PLIFLPPVSGTADVFFQQILALTGWGYRVIALQYP--------------VYWDHLEFcdgFRKLLDHLQLDKVHLFGASL 110
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRgfgkssrpkaqddyRTDDLAED---LEYILEALGLEKVNLVGHSM 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 55741780   111 GGFLAqkfAEYTHKSP-RVHSLILCNAFSDTSIFNQTW 147
Cdd:pfam00561  79 GGLIA---LAYAAKYPdRVKALVLLGALDPPHELDEAD 113
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 45-139 1.07e-11

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 62.71  E-value: 1.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741780  45 PLIFLPPVSGTADVFFQQILALTGwGYRVIALQYPVY---------WDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLA 115
Cdd:COG0596  25 PVVLLHGLPGSSYEWRPLIPALAA-GYRVIAPDLRGHgrsdkpaggYTLDDLADDLAALLDALGLERVVLVGHSMGGMVA 103

                        90       100
                ....*....|....*....|....
gi 55741780 116 QKFAEytHKSPRVHSLILCNAFSD 139
Cdd:COG0596 104 LELAA--RHPERVAGLVLVDEVLA 125
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 45-147 1.01e-08

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 54.43  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741780    45 PLIFLPPVSGTADVFFQQILALTGWGYRVIALQYP--------------VYWDHLEFcdgFRKLLDHLQLDKVHLFGASL 110
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRgfgkssrpkaqddyRTDDLAED---LEYILEALGLEKVNLVGHSM 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 55741780   111 GGFLAqkfAEYTHKSP-RVHSLILCNAFSDTSIFNQTW 147
Cdd:pfam00561  79 GGLIA---LAYAAKYPdRVKALVLLGALDPPHELDEAD 113
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 35-132 1.63e-07

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 48.29  E-value: 1.63e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741780  35 YDAGPRsircPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVY----WDHLEFCDGF-RKLLDHLQLDKVHLFGAS 109
Cdd:COG1075   1 YAATRY----PVVLVHGLGGSAASWAPLAPRLRAAGYPVYALNYPSTngsiEDSAEQLAAFvDAVLAATGAEKVDLVGHS 76

                        90       100
                ....*....|....*....|...
gi 55741780 110 LGGFLAQKFAEYTHKSPRVHSLI 132
Cdd:COG1075  77 MGGLVARYYLKRLGGAAKVARVV 99
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
45-135 3.45e-04

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 40.76  E-value: 3.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741780  45 PLIFLPPVSGTADVFFQQILALTGWGYRVIALQYP---------VYWDHLE-FCDGFRKLLDHLQLD---KVHLFGASLG 111
Cdd:COG2267  30 TVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRghgrsdgprGHVDSFDdYVDDLRAALDALRARpglPVVLLGHSMG 109

                        90       100
                ....*....|....*....|....
gi 55741780 112 GFLAQKFAEytHKSPRVHSLILCN 135
Cdd:COG2267 110 GLIALLYAA--RYPDRVAGLVLLA 131
Thioesterase pfam00975
Thioesterase domain; Peptide synthetases are involved in the non-ribosomal synthesis of ...
 45-142 9.12e-04

Thioesterase domain; Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics. Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates. There are also modules within the peptide synthetases that also share this similarity. With respect to antibiotic production, thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Thioesterases (non-integrated) have molecular masses of 25-29 kDa.


Pssm-ID: 395776 [Multi-domain]  Cd Length: 223  Bit Score: 39.68  E-value: 9.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741780    45 PLIFLPPVSGTADVFFQQILALTGWgYRVIALQYPVYWDHLEFCDGFRKLLD--------HLQLDKVHLFGASLGGFLAQ 116
Cdd:pfam00975   2 PLFCFPPAGGSASSFRSLARRLPPP-AEVLAVQYPGRGRGEPPLNSIEALADeyaealrqIQPEGPYALFGHSMGGMLAF 80

                          90       100
                  ....*....|....*....|....*..
gi 55741780   117 KFA-EYTHKSPRVHSLILcnafSDTSI 142
Cdd:pfam00975  81 EVArRLERQGEAVRSLFL----SDASA 103
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
53-159 8.29e-03

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 36.53  E-value: 8.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741780  53 SGTADVFFQQILALTGWGYRVIALQYPVY---------WDHLEFCDGFRKLLDHLQLD--KVHLFGASLGGFLAQKFAey 121
Cdd:COG1506  34 GSRDDSFLPLAQALASRGYAVLAPDYRGYgesagdwggDEVDDVLAAIDYLAARPYVDpdRIGIYGHSYGGYMALLAA-- 111

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 55741780 122 THKSPRVHSLILCNAFSDtsifNQTWTANSFWLMPAFM 159
Cdd:COG1506 112 ARHPDRFKAAVALAGVSD----LRSYYGTTREYTERLM 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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