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Conserved domains on  [gi|54635068|ref|NP_001006598|]
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olfactory receptor Olr1362 [Rattus norvegicus]

Protein Classification

family 1 olfactory receptor( domain architecture ID 11610387)

family 1 olfactory receptor is a G-protein coupled receptor (GPCR) that plays a central role in olfaction, the sense of smell; GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
33-294 4.14e-165

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 459.77  E-value: 4.14e-165
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15918   9 GMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDN 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15918  89 FLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd15918 169 HLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSASKDS 248
                       250       260
                ....*....|....*....|..
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15918 249 VAAVMYTVVTPMLNPFIYSLRN 270
 
Name Accession Description Interval E-value
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
33-294 4.14e-165

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 459.77  E-value: 4.14e-165
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15918   9 GMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDN 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15918  89 FLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd15918 169 HLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSASKDS 248
                       250       260
                ....*....|....*....|..
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15918 249 VAAVMYTVVTPMLNPFIYSLRN 270
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
34-305 2.01e-49

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 165.75  E-value: 2.01e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068    34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:pfam13853   4 MYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068   114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:pfam13853  84 VLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIK 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068   194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGR--D 271
Cdd:pfam13853 164 VNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPllQ 243
                         250       260       270
                  ....*....|....*....|....*....|....
gi 54635068   272 TAAAVMYTVVTPMLNPFIYSLRNRDMKVALRKVL 305
Cdd:pfam13853 244 IMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
 
Name Accession Description Interval E-value
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
33-294 4.14e-165

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 459.77  E-value: 4.14e-165
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15918   9 GMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDN 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15918  89 FLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd15918 169 HLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSASKDS 248
                       250       260
                ....*....|....*....|..
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15918 249 VAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
33-301 1.66e-158

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 443.59  E-value: 1.66e-158
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15235  10 AMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15235  90 FLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd15235 170 SLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSSYSADKDR 249
                       250       260
                ....*....|....*....|....*....
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15235 250 VATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
33-294 7.96e-137

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 387.99  E-value: 7.96e-137
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd13954   9 LIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd13954  89 FLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd13954 169 SLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSYSSDLDK 248
                       250       260
                ....*....|....*....|..
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd13954 249 VVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
33-301 2.12e-132

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 377.30  E-value: 2.12e-132
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15234   9 SMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDN 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15234  89 FLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd15234 169 LINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTHSSRKTA 248
                       250       260
                ....*....|....*....|....*....
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15234 249 VASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
33-301 1.68e-130

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 372.56  E-value: 1.68e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15225   9 LIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15225  89 FLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd15225 169 SLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYSPETDK 248
                       250       260
                ....*....|....*....|....*....
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15225 249 LLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
34-294 1.36e-127

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 364.91  E-value: 1.36e-127
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15230  10 IYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15230  90 LLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDTH 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15230 170 INELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYSLDQDKV 249
                       250       260
                ....*....|....*....|.
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15230 250 VSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
34-301 3.04e-120

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 346.37  E-value: 3.04e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15236  10 MYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15236  90 LLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTS 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15236 170 LNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDKDIV 249
                       250       260
                ....*....|....*....|....*...
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15236 250 ASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
34-294 3.44e-118

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 341.00  E-value: 3.44e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15912  10 TYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15912  90 LLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLSCSDTR 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15912 170 LIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQSSSLDLNKV 249
                       250       260
                ....*....|....*....|.
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15912 250 VALLNTVVTPLLNPFIYTLRN 270
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
33-301 1.00e-116

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 337.70  E-value: 1.00e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15231   9 IIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15231  89 LLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd15231 169 SLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGYSLDKDT 248
                       250       260
                ....*....|....*....|....*....
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15231 249 LISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
11-305 1.56e-115

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 335.10  E-value: 1.56e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  11 EFLLLGLSRQPQQQQFLFLLFLTMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQ 90
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  91 KISFSGCLTQLYFLCIFGDMDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCA 170
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 171 DNIIPHFFCDVTPLLKLSCSDTHLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCL 250
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 54635068 251 FYGTVITVYFNPSTSYSAGRDTAAAVMYTVVTPMLNPFIYSLRNRDMKVALRKVL 305
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
35-294 1.86e-115

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 334.07  E-value: 1.86e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15911  11 YIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15911  91 LAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDTSL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTAA 274
Cdd:cd15911 171 VELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTSRDLNKVF 250
                       250       260
                ....*....|....*....|
gi 54635068 275 AVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15911 251 SLFYTVLTPLVNPLIYSLRN 270
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
12-305 2.71e-115

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 334.63  E-value: 2.71e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  12 FLLLGLSRQPQQQQFLFLLFLTMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQK 91
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  92 ISFSGCLTQLYFLCIFGDMDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCAD 171
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 172 NIIPHFFCDVTPLLKLSCSDTHLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLF 251
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 54635068 252 YGTVITVYFNPSTSYSAGRDTAAAVMYTVVTPMLNPFIYSLRNRDMKVALRKVL 305
Cdd:cd15410 241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
12-298 3.02e-115

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 334.29  E-value: 3.02e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  12 FLLLGLSRQPQQQQFLFLLFLTMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQK 91
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  92 ISFSGCLTQLYFLCIFGDMDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCAD 171
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 172 NIIPHFFCDVTPLLKLSCSDTHLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLF 251
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 54635068 252 YGTVITVYFNPSTSYSAGRDTAAAVMYTVVTPMLNPFIYSLRNRDMK 298
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
33-303 1.41e-114

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 332.35  E-value: 1.41e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15419   9 VIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEG 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15419  89 FLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd15419 169 FINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVSSPEQSK 248
                       250       260       270
                ....*....|....*....|....*....|.
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRNRDMKVALRK 303
Cdd:cd15419 249 VVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
35-303 4.35e-112

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 325.75  E-value: 4.35e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15417  11 YLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15417  91 LAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDTFI 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTAA 274
Cdd:cd15417 171 SQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHSQDQDKVA 250
                       250       260
                ....*....|....*....|....*....
gi 54635068 275 AVMYTVVTPMLNPFIYSLRNRDMKVALRK 303
Cdd:cd15417 251 SVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
35-303 8.78e-112

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 325.04  E-value: 8.78e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15411  11 YVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15411  91 LGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTHV 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTAA 274
Cdd:cd15411 171 NEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYSLGQDKVA 250
                       250       260
                ....*....|....*....|....*....
gi 54635068 275 AVMYTVVTPMLNPFIYSLRNRDMKVALRK 303
Cdd:cd15411 251 SVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
34-294 5.42e-111

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 322.87  E-value: 5.42e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15227  10 IYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15227  90 LLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLSCSDTY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15227 170 LNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSPSLLDLL 249
                       250       260
                ....*....|....*....|.
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15227 250 LSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
35-301 9.76e-110

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 319.93  E-value: 9.76e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15229  11 YLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15229  91 LSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFA 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTAA 274
Cdd:cd15229 171 NKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSSVLDRVF 250
                       250       260
                ....*....|....*....|....*..
gi 54635068 275 AVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15229 251 SIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
33-294 6.33e-108

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 314.93  E-value: 6.33e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15431   9 IVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMaRLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15431  89 LLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTM-PLHFCGPNVINHFFCEVQALLKLACSDT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd15431 168 SLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSSSDQDK 247
                       250       260
                ....*....|....*....|..
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15431 248 IISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
16-305 7.80e-108

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 315.46  E-value: 7.80e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  16 GLSRQPQQQQFLFLLFLTMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFS 95
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  96 GCLTQLYFLCIFGDMDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIP 175
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 176 HFFCDVTPLLKLSCSDTHLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTV 255
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 54635068 256 ITVYFNPSTSYSAGRDTAAAVMYTVVTPMLNPFIYSLRNRDMKVALRKVL 305
Cdd:cd15406 241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
35-294 1.13e-105

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 309.19  E-value: 1.13e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15232  11 YAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15232  91 LTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDTSL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTAA 274
Cdd:cd15232 171 NEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSYSPEKDKVV 250
                       250       260
                ....*....|....*....|
gi 54635068 275 AVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15232 251 AVLYSVVTPTLNPLIYSLRN 270
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
33-294 2.40e-105

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 308.44  E-value: 2.40e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15237   9 LIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15237  89 VLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACADT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd15237 169 SLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHSPDQDK 248
                       250       260
                ....*....|....*....|..
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15237 249 MISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
33-301 1.19e-104

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 306.78  E-value: 1.19e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15421   9 LIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15421  89 LLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCADT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd15421 169 SAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYHSPEQDK 248
                       250       260
                ....*....|....*....|....*....
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15421 249 VVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
33-301 1.76e-103

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 303.94  E-value: 1.76e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15429   9 VMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15429  89 ILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd15429 169 SLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSSALQEK 248
                       250       260
                ....*....|....*....|....*....
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15429 249 MISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
12-303 1.61e-102

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 302.05  E-value: 1.61e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  12 FLLLGLSRQPQQQQFLFLLFLTMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQK 91
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  92 ISFSGCLTQLYFLCIFGDMDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCAD 171
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 172 NIIPHFFCDVTPLLKLSCSDTHLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLF 251
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 54635068 252 YGTVITVYFNPSTSYSAGRDTAAAVMYTVVTPMLNPFIYSLRNRDMKVALRK 303
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
33-301 2.15e-102

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 301.17  E-value: 2.15e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15420   9 LLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15420  89 VLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACADT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd15420 169 WINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSAEQEK 248
                       250       260
                ....*....|....*....|....*....
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15420 249 ILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
34-303 3.54e-102

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 300.87  E-value: 3.54e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15415  10 IYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15415  90 LLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDTH 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15415 170 INELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYSLEQEKV 249
                       250       260       270
                ....*....|....*....|....*....|
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRNRDMKVALRK 303
Cdd:cd15415 250 SAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
34-303 4.94e-102

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 300.48  E-value: 4.94e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15409  10 IYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15409  90 LLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDPS 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15409 170 INELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALDQDMM 249
                       250       260       270
                ....*....|....*....|....*....|
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRNRDMKVALRK 303
Cdd:cd15409 250 DSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
12-305 3.24e-101

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 299.01  E-value: 3.24e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  12 FLLLGLSRQPQQQQFLFLLFLTMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQK 91
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  92 ISFSGCLTQLYFLCIFGDMDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCAD 171
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 172 NIIPHFFCDVTPLLKLSCSDTHLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLF 251
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 54635068 252 YGTVITVYFNPSTSYSAGRDTAAAVMYTVVTPMLNPFIYSLRNRDMKVALRKVL 305
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
34-303 4.49e-100

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 295.43  E-value: 4.49e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15416  10 IYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15416  90 LLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDIR 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15416 170 LAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMDQNKV 249
                       250       260       270
                ....*....|....*....|....*....|
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRNRDMKVALRK 303
Cdd:cd15416 250 VSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
33-303 1.28e-99

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 294.31  E-value: 1.28e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15412   9 VIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEY 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15412  89 YMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd15412 169 YVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESVEQSK 248
                       250       260       270
                ....*....|....*....|....*....|.
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRNRDMKVALRK 303
Cdd:cd15412 249 IVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
34-303 2.65e-99

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 293.46  E-value: 2.65e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15413  10 IYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15413  90 LLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDTH 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15413 170 EKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHSLDTDKM 249
                       250       260       270
                ....*....|....*....|....*....|
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRNRDMKVALRK 303
Cdd:cd15413 250 ASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
35-294 3.35e-99

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 292.67  E-value: 3.35e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15915  11 YLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAML 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15915  91 LAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDTSL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHI-TWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15915 171 NLWLLNIVTGSIALGTFILTLLSYIYIiSFLLLKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDSLEQDRI 250
                       250       260
                ....*....|....*....|.
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15915 251 VALLYTVVTPVLNPLIYTLRN 271
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
35-294 1.75e-98

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 291.11  E-value: 1.75e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15224  11 YVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15224  91 LAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDMSL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTAA 274
Cdd:cd15224 171 AELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISSFDSNKLV 250
                       250       260
                ....*....|....*....|
gi 54635068 275 AVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15224 251 SVLYTVVTPLLNPIIYCLRN 270
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
34-294 3.55e-97

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 287.57  E-value: 3.55e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15939  10 IYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15939  90 LLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHItWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAgrDTA 273
Cdd:cd15939 170 VIGLLVVANSGLICLLSFLILLISYIVI-LYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFPI--DKV 246
                       250       260
                ....*....|....*....|.
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15939 247 VAVFYTIITPMLNPLIYTLRN 267
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
35-294 5.43e-95

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 282.20  E-value: 5.43e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANhILGSQK-ISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15947  11 YLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVN-LWGPDKtISYGGCVTQLYIFLWLGSTECV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15947  90 LLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKLACVDTT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15947 170 FNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSYSQDQGKF 249
                       250       260
                ....*....|....*....|.
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15947 250 ISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
34-303 1.40e-94

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 281.23  E-value: 1.40e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15407  10 IYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15407  90 LLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSCSDIH 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15407 170 ISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSMDTDKM 249
                       250       260       270
                ....*....|....*....|....*....|
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRNRDMKVALRK 303
Cdd:cd15407 250 ASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
35-309 2.63e-92

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 275.84  E-value: 2.63e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15414  11 YLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15414  91 LASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADTQI 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTAA 274
Cdd:cd15414 171 NKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSSLDLDKVV 250
                       250       260       270
                ....*....|....*....|....*....|....*
gi 54635068 275 AVMYTVVTPMLNPFIYSLRNRDMKVALRKVLAMRF 309
Cdd:cd15414 251 SVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRKM 285
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
34-294 2.69e-92

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 275.40  E-value: 2.69e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15430  10 MYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15430  90 LLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDIS 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15430 170 LNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNAQISDKL 249
                       250       260
                ....*....|....*....|.
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15430 250 ITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
35-304 5.21e-92

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 275.12  E-value: 5.21e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15418  12 YILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECFL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15418  92 LAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDTRV 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTAA 274
Cdd:cd15418 172 YELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHTPDRDKVV 251
                       250       260       270
                ....*....|....*....|....*....|
gi 54635068 275 AVMYTVVTPMLNPFIYSLRNRDMKVALRKV 304
Cdd:cd15418 252 ALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
35-301 1.66e-90

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 270.79  E-value: 1.66e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANhILGSQK-ISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15434  11 YLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVN-LWGPDKtISYVGCAIQLFIALGLGGTECV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15434  90 LLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIKLACVDTT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15434 170 AYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSVSQDQGKF 249
                       250       260
                ....*....|....*....|....*...
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15434 250 LTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
35-301 7.38e-90

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 269.30  E-value: 7.38e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15424  11 YLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15424  91 LGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADTHI 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTAA 274
Cdd:cd15424 171 TEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGSTPDRDKQI 250
                       250       260
                ....*....|....*....|....*..
gi 54635068 275 AVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15424 251 AVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
34-301 1.27e-89

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 268.55  E-value: 1.27e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQK-ISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15916  10 IYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGGKvISFGGCVAQLYFFHFLGSTEC 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15916  90 FLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAgrDT 272
Cdd:cd15916 170 TINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSKEAL--DG 247
                       250       260
                ....*....|....*....|....*....
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15916 248 VIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
35-294 8.88e-89

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 266.16  E-value: 8.88e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15914  11 YLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITECYL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15914  91 LTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDTSL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTAA 274
Cdd:cd15914 171 NVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYSLDYDRAI 250
                       250       260
                ....*....|....*....|
gi 54635068 275 AVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15914 251 AVVYAVLTPFFNPIIYSLRN 270
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
34-301 9.39e-89

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 266.59  E-value: 9.39e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15405  10 IYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15405  90 VLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTSTY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15405 170 VNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSVNQGKV 249
                       250       260
                ....*....|....*....|....*...
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15405 250 SSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
35-294 2.31e-88

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 265.22  E-value: 2.31e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15226  11 YVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15226  91 LIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTDTYV 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHITWAVlRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAgrDTAA 274
Cdd:cd15226 171 LELMVVANSGLISLVCFLLLLISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFPV--DKFL 247
                       250       260
                ....*....|....*....|
gi 54635068 275 AVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15226 248 AVFYTVITPLLNPIIYTLRN 267
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
35-301 3.66e-88

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 265.06  E-value: 3.66e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15228  11 YLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15228  91 YTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACADTSI 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTsySAGRDTAA 274
Cdd:cd15228 171 AETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP--SPVLVTPV 248
                       250       260
                ....*....|....*....|....*..
gi 54635068 275 AVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15228 249 QIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
35-301 7.19e-87

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 261.65  E-value: 7.19e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15233  11 YIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15233  91 LTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTHL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTAA 274
Cdd:cd15233 171 NELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVYSSDKDKVI 250
                       250       260
                ....*....|....*....|....*..
gi 54635068 275 AVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15233 251 GILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
33-294 2.04e-86

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 260.33  E-value: 2.04e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15913   9 VIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15913  89 FFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCVPA 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:cd15913 169 PGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNSTGMQK 248
                       250       260
                ....*....|....*....|..
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15913 249 IVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
34-294 5.74e-86

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 258.91  E-value: 5.74e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15940  10 LYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15940  90 LLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDTY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSpRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAgrDTA 273
Cdd:cd15940 170 LIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRST-EGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFSE--DKV 246
                       250       260
                ....*....|....*....|.
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15940 247 VSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
33-294 4.85e-84

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 254.18  E-value: 4.85e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15936   9 LVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15936  89 FLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITwAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAgrDT 272
Cdd:cd15936 169 FLLELLMVSNSGLVTLLIFFILLISYTVIL-VKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFPM--DK 245
                       250       260
                ....*....|....*....|..
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15936 246 AVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
35-301 5.93e-84

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 254.33  E-value: 5.93e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANhILGSQK-ISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15432  11 YILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVN-LRSPQKtISYGGCVAQLFIFLGLGSTECV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15432  90 LLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15432 170 ANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHDRGKM 249
                       250       260
                ....*....|....*....|....*...
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15432 250 VALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
34-301 1.74e-82

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 250.47  E-value: 1.74e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15428  10 IYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15428  90 LLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTH 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15428 170 QAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSSTSKEYDKM 249
                       250       260
                ....*....|....*....|....*...
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15428 250 ISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
33-301 2.39e-82

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 250.15  E-value: 2.39e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHT-PMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQK-ISFSGCLTQLYFLCIFGDM 110
Cdd:cd15941   9 LIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSGRtISFEGCVVQLYAFHFLAST 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 111 DNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCS 190
Cdd:cd15941  89 ECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACA 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 191 DTHLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAgr 270
Cdd:cd15941 169 DTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSSQAG-- 246
                       250       260       270
                ....*....|....*....|....*....|.
gi 54635068 271 DTAAAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15941 247 AGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
34-294 4.08e-82

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 249.32  E-value: 4.08e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15946  10 IYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECT 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15946  90 LFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACADTS 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15946 170 LNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNYSPERDKK 249
                       250       260
                ....*....|....*....|.
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15946 250 ISLFYNVFTALLNPVIYSLRN 270
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
35-301 7.87e-79

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 241.23  E-value: 7.87e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15433  11 YLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15433  91 LAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDET 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTAA 274
Cdd:cd15433 171 TEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRYSQAHGKFV 250
                       250       260
                ....*....|....*....|....*..
gi 54635068 275 AVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15433 251 SLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
34-301 1.48e-78

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 240.41  E-value: 1.48e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15942  10 VYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15942  90 LYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTA 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAgrDTA 273
Cdd:cd15942 170 FNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDPL--DGV 247
                       250       260
                ....*....|....*....|....*...
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15942 248 VAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
35-294 1.67e-71

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 222.06  E-value: 1.67e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15938  11 YTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHL 194
Cdd:cd15938  91 LTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTCV 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 195 NELMILTEGAVVMVTPFVCILISYIHItwaVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAgrDTAA 274
Cdd:cd15938 171 TELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFPV--DKHV 245
                       250       260
                ....*....|....*....|
gi 54635068 275 AVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15938 246 SVLYNVITPMLNPLIYTLRN 265
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
35-294 2.68e-69

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 216.55  E-value: 2.68e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRL-HTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15935  11 YAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEML 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15935  91 LLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTY 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYiHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSagRDTA 273
Cdd:cd15935 171 VVEVLMVANSGLLSLVCFLVLLVSY-GIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSSSS--VDKV 247
                       250       260
                ....*....|....*....|.
gi 54635068 274 AAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15935 248 ASVFYTLITPALNPLIYTLRN 268
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
33-301 3.55e-68

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 214.08  E-value: 3.55e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15223   9 LLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAMES 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15223  89 SILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACGDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFnpstSYSAGRDT 272
Cdd:cd15223 169 TINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSL----TYRFGKTI 244
                       250       260       270
                ....*....|....*....|....*....|....*
gi 54635068 273 AA------AVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15223 245 PPdvhvllSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
33-294 1.89e-67

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 211.90  E-value: 1.89e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15937   9 LFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEM 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15937  89 FLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLACTNT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITwAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAgrDT 272
Cdd:cd15937 169 YTVELLMFSNSGLVILLCFLLLLISYAFLL-AKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSFPM--DK 245
                       250       260
                ....*....|....*....|..
gi 54635068 273 AAAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd15937 246 VVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
34-297 2.26e-66

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 209.07  E-value: 2.26e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15917  10 MYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESG 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15917  90 VLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDTR 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15917 170 VNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHVPPHVH 249
                       250       260
                ....*....|....*....|....*.
gi 54635068 274 A--AVMYTVVTPMLNPFIYSLRNRDM 297
Cdd:cd15917 250 IllANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
34-295 9.44e-64

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 202.35  E-value: 9.44e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15222  10 LYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALlvMGswVVANMNCLLHIL----LMARLSFCADNIIPHFFCDVTPLLKLSC 189
Cdd:cd15222  90 VLLAMAFDRFVAICNPLRYASILTNSRIAK--IG--LAIVLRSVLLLLplpfLLKRLPFCHSNVLSHSYCLHQDVMKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 190 SDTHLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVyfnpSTSYSAG 269
Cdd:cd15222 166 SDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGL----SMVHRFG 241
                       250       260       270
                ....*....|....*....|....*....|..
gi 54635068 270 RDTAAAV------MYTVVTPMLNPFIYSLRNR 295
Cdd:cd15222 242 KHASPLVhvlmanVYLLVPPVLNPIIYSVKTK 273
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
34-295 7.58e-63

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 200.21  E-value: 7.58e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15221  10 MYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTESA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGswVVANMNCLLH--ILLMARLSFCADNIIPHFFCDVTPLLKLSCSD 191
Cdd:cd15221  90 ILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVA--AVARSFCIVFpfVFLLKRLPYCGHNVIPHTYCEHMGIARLACAD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 192 THLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYG----TVITVYFNPSTSYS 267
Cdd:cd15221 168 ITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTpaffSFLTHRFGRHIPRH 247
                       250       260
                ....*....|....*....|....*...
gi 54635068 268 AgrDTAAAVMYTVVTPMLNPFIYSLRNR 295
Cdd:cd15221 248 V--HILLANLYVLVPPMLNPIVYGVKTK 273
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
33-295 3.05e-62

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 198.79  E-value: 3.05e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15950   9 SMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVES 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCAllVMGSWVVANMNCLLHIL--LMARLSFCADNIIPHFFCDVTPLLKLSCS 190
Cdd:cd15950  89 GVLLAMAFDRYVAICHPLRYSAILTSQVIA--QIGLAIVLRALLFMTPLtcLVTSLPYCGSRVVPHSYCEHMAVVKLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 191 DTHLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGR 270
Cdd:cd15950 167 DPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRFGQGVPP 246
                       250       260
                ....*....|....*....|....*..
gi 54635068 271 DTAA--AVMYTVVTPMLNPFIYSLRNR 295
Cdd:cd15950 247 HTQVllADLYLLVPPMLNPIIYGMRTK 273
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
33-295 3.89e-62

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 198.37  E-value: 3.89e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15952   9 AVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMES 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15952  89 AVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACASI 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNeLMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFnpstSYSAGRDT 272
Cdd:cd15952 169 RIN-IIYGLFAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFL----THRFGHNI 243
                       250       260
                ....*....|....*....|....*....
gi 54635068 273 A------AAVMYTVVTPMLNPFIYSLRNR 295
Cdd:cd15952 244 PryihilLANLYVVLPPMLNPVIYGVRTK 272
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
33-295 1.32e-61

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 197.18  E-value: 1.32e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15951   9 IMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMES 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15951  89 GIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYgtvITVYFNpSTSYSAGRDT 272
Cdd:cd15951 169 RVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFY---IPALFS-FLTHRFGHNV 244
                       250       260
                ....*....|....*....|....*....
gi 54635068 273 A------AAVMYTVVTPMLNPFIYSLRNR 295
Cdd:cd15951 245 PphvhilIANVYLLVPPMLNPIIYGVRTK 273
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
33-295 1.09e-60

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 194.79  E-value: 1.09e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15953   9 LMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIMES 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15953  89 AVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACGDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYgtviTVYFNPSTSYSAGRDT 272
Cdd:cd15953 169 TINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSY----TPALFSFLTHRFGQGI 244
                       250       260
                ....*....|....*....|....*....
gi 54635068 273 AAAV------MYTVVTPMLNPFIYSLRNR 295
Cdd:cd15953 245 APHIhiilanLYLLVPPMLNPIIYGVKTK 273
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
34-305 2.01e-49

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 165.75  E-value: 2.01e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068    34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:pfam13853   4 MYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068   114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:pfam13853  84 VLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIK 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068   194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGR--D 271
Cdd:pfam13853 164 VNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPllQ 243
                         250       260       270
                  ....*....|....*....|....*....|....
gi 54635068   272 TAAAVMYTVVTPMLNPFIYSLRNRDMKVALRKVL 305
Cdd:pfam13853 244 IMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
33-298 1.95e-48

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 163.15  E-value: 1.95e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15948  10 SAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMES 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDT 192
Cdd:cd15948  90 AVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACGDT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 193 HLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYGTVITvyfnPSTSYSAGRDT 272
Cdd:cd15948 170 RFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVL----SSTMHRFARHV 245
                       250       260       270
                ....*....|....*....|....*....|..
gi 54635068 273 AA------AVMYTVVTPMLNPFIYSLRNRDMK 298
Cdd:cd15948 246 APhvhillANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
10-298 1.28e-45

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 156.48  E-value: 1.28e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  10 TEFLLLGLSRQPQQQQFLFLLFLTMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGS 89
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  90 QKISFSGCLTQLYFLCIFGDMDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSwVVANMNCLLHILLMA-RLSF 168
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAA-VIRGVLYISPLPLLVrRLPW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 169 CADNIIPHFFCDVTPLLKLSCSDTHLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVV 248
Cdd:cd15949 161 YRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 54635068 249 CLFYGTVITvyfnPSTSYSAGRD------TAAAVMYTVVTPMLNPFIYSLRNRDMK 298
Cdd:cd15949 241 LAFYVPIAV----SSLIHRFGQNvpppthILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
34-297 3.94e-44

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 151.90  E-value: 3.94e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15954  10 MYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESG 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15954  90 VLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACANIR 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHltvVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd15954 170 VDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAH---ICAIVITYTPAFFTFFAHRFGGHHIT 246
                       250       260       270
                ....*....|....*....|....*....|
gi 54635068 274 A------AVMYTVVTPMLNPFIYSLRNRDM 297
Cdd:cd15954 247 PhihiimANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
34-295 8.43e-43

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 148.47  E-value: 8.43e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15956  10 IYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESG 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd15956  90 VLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACGATT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYG----TVITVYFNPSTSYSAg 269
Cdd:cd15956 170 VDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIpgllSVLMHRFGHSVPSAA- 248
                       250       260
                ....*....|....*....|....*.
gi 54635068 270 rDTAAAVMYTVVTPMLNPFIYSLRNR 295
Cdd:cd15956 249 -HVLLSNLYLLLPPALNPIVYGIRTK 273
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
33-297 4.84e-39

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 138.75  E-value: 4.84e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15955   9 IMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFES 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVcaLLVMGSWVV---ANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSC 189
Cdd:cd15955  89 GILLAMALDRYVAICHPLRHSSILTPQV--LLGIGVLVVvraVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 190 SDTHLNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGWKAFSTCGSHLTVVCLFYgtviTVYFNPSTSYSAG 269
Cdd:cd15955 167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFY----TLAFFSFFAHRFG 242
                       250       260       270
                ....*....|....*....|....*....|....
gi 54635068 270 RDTAAAV------MYTVVTPMLNPFIYSLRNRDM 297
Cdd:cd15955 243 HHVAPYVhillsnLYLLVPPVLNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
41-290 4.99e-38

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 135.50  E-value: 4.99e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068    41 GNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQK-ISFSGCLTQLYFLCIFGDMDNFLLAVMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWpFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068   120 YDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNiipHFFCDVTPLLKLSCsdthlNELMI 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSK-----PVSYT 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068   200 LTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGGW-------KAFSTCGSHLTVVCLFYGTVITVYFNPSTSYSAGRDT 272
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSR 232
                         250       260
                  ....*....|....*....|....
gi 54635068   273 A------AAVMYTVVTPMLNPFIY 290
Cdd:pfam00001 233 LldkalsVTLWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
36-294 1.50e-23

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 97.36  E-value: 1.50e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd00637  10 VVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCdvtpllklscsDTHLN 195
Cdd:cd00637  90 TAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWP-----------DLTLS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 196 ELMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPRGG--------------WKAFSTCgshLTVVCLFY-------GT 254
Cdd:cd00637 159 KAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSsssnssrrrrrrreRKVTKTL---LIVVVVFLlcwlpyfIL 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 54635068 255 VITVYFNPSTSYSAGRDTAAAVMYTVVTPMLNPFIYSLRN 294
Cdd:cd00637 236 LLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
36-301 2.33e-19

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 85.69  E-value: 2.33e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCL--TQLYFLCIFGDMDNf 113
Cdd:cd14967  11 LVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRfwIALDVLCCTASILN- 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 lLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVAnmncllhiLLMARLSFCADNIIPHFFCDVTpllklsCSDTH 193
Cdd:cd14967  90 -LCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYS--------LLISLPPLVGWRDETQPSVVDC------ECEFT 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHITWAVLRVSsprggwKAFSTCGshlTVVCLFYGTVITVYFNPSTSYSAGRDTA 273
Cdd:cd14967 155 PNKIYVLVSSVISFFIPLLIMIVLYARIFRVARREL------KAAKTLA---IIVGAFLLCWLPFFIIYLVSAFCPPDCV 225
                       250       260       270
                ....*....|....*....|....*....|....
gi 54635068 274 AAVMYTVVT------PMLNPFIYSLRNRDMKVAL 301
Cdd:cd14967 226 PPILYAVFFwlgylnSALNPIIYALFNRDFRRAF 259
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
36-152 6.02e-12

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 64.97  E-value: 6.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPnvLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd14968  12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLFMACLVLVLTQSSIFSL 89
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd14968  90 LAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLS 126
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
36-152 5.81e-11

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 62.08  E-value: 5.81e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGC--LTQLYFLCIFGDMDNf 113
Cdd:cd15058  12 LAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCelWTSVDVLCVTASIET- 90
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 54635068 114 lLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15058  91 -LCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVS 128
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
36-152 9.44e-11

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 61.42  E-value: 9.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVD-------VCFSSttapnvlanhILGSQKISFSG---CLTQLYFLC 105
Cdd:cd15055  12 LLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADflvgllvMPFSM----------IRSIETCWYFGdtfCKLHSSLDY 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 54635068 106 IFGDMDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15055  82 ILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVS 128
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
36-150 1.86e-10

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 60.68  E-value: 1.86e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd14969  12 VLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTL 91
                        90       100       110
                ....*....|....*....|....*....|....*
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVcALLVMGSWV 150
Cdd:cd14969  92 AALAFERYLVIVRPLKAFRLSKRRA-LILIAFIWL 125
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
36-151 5.32e-10

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 59.38  E-value: 5.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15317  12 LITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTTSIFHL 91
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVV 151
Cdd:cd15317  92 CFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLV 127
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
34-151 5.33e-10

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 59.29  E-value: 5.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15312  10 AILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIF 89
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVV 151
Cdd:cd15312  90 HLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSV 127
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
36-151 2.41e-09

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 57.18  E-value: 2.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHL 91
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVV 151
Cdd:cd15318  92 CFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLV 127
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
33-149 7.56e-09

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 55.71  E-value: 7.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLY------FLCI 106
Cdd:cd15354   9 TLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIdnvfdsLICI 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 54635068 107 FGDMDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSW 149
Cdd:cd15354  89 SVVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIW 131
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
38-152 7.71e-09

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 55.93  E-value: 7.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  38 TVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKI-SFSGCLTQLYFLCIFGDMDNFLLA 116
Cdd:cd15005  14 SLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHSAFTLF 93
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 54635068 117 VMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15005  94 CIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLS 129
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
36-151 1.08e-08

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 55.05  E-value: 1.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSG-CLTQLYFLCIFGDMDNFL 114
Cdd:cd15067  11 LVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYWLFGRDwCDVWHSFDVLASTASILN 90
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVV 151
Cdd:cd15067  91 LCVISLDRYWAITDPISYPSRMTKRRALIMIALVWIC 127
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
38-152 1.42e-08

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 55.05  E-value: 1.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  38 TVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLLAV 117
Cdd:cd15065  13 AIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASILNLCA 92
                        90       100       110
                ....*....|....*....|....*....|....*
gi 54635068 118 MAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15065  93 ISLDRYIHIKKPLKYERWMTTRRALVVIASVWILS 127
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
38-152 1.50e-08

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 54.94  E-value: 1.50e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  38 TVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPnvLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLLAV 117
Cdd:cd15069  14 SVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIP--FAITISLGFCTDFHSCLFLACFVLVLTQSSIFSLLA 91
                        90       100       110
                ....*....|....*....|....*....|....*
gi 54635068 118 MAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15069  92 VAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLA 126
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
38-301 2.68e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 53.84  E-value: 2.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  38 TVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDvCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLLAV 117
Cdd:cd14972  12 IVVENSLVLAAIIKNRRLHKPMYILIANLAAAD-LLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLASAYSLLA 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 118 MAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVAnmncllhiLLMArlsfcadnIIPHFFCDVTPLLKLSCSDT----H 193
Cdd:cd14972  91 IAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWS--------VLLA--------LLPVLGWNCVLCDQESCSPLgpglP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 194 LNELMILTegaVVMVTPFVCILISYIHITWAVLRVSSprgGWKAFSTC--GSHLTVVCLFYGTVITVY------------ 259
Cdd:cd14972 155 KSYLVLIL---VFFFIALVIIVFLYVRIFWCLWRHAN---AIAARQEAavPAQPSTSRKLAKTVVIVLgvflvcwlplli 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 54635068 260 ------FNPSTSYSAGRDTAAAVMyTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd14972 229 llvldvLCPSVCDIQAVFYYFLVL-ALLNSAINPIIYAFRLKEMRRAV 275
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
36-221 2.90e-08

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 53.97  E-value: 2.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMY-FFLCSLSFVDVCFSSTTAPNVLANHILGSQKI-SFSGCLTQLYFLCIFGDMDNf 113
Cdd:cd15057  12 LLTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFgSFCDVWVSFDIMCSTASILN- 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 lLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLsfcADNIIPHFFCDVTPllkLSCsDTH 193
Cdd:cd15057  91 -LCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQLGWHR---ADDTSEALALYADP---CQC-DSS 162
                       170       180
                ....*....|....*....|....*...
gi 54635068 194 LNELMILTEGAVVMVTPFVCILISYIHI 221
Cdd:cd15057 163 LNRTYAISSSLISFYIPVAIMIVTYTRI 190
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
33-150 3.05e-08

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 53.65  E-value: 3.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLY------FLCI 106
Cdd:cd15103   9 TLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIdnvidsMICS 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 54635068 107 FGDMDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWV 150
Cdd:cd15103  89 SLLASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWV 132
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
34-161 3.08e-08

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 53.79  E-value: 3.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNV--LIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGsQKISFSGCLTQLYFLCI--FGD 109
Cdd:cd14981  10 MFVFGVLGNLlaLIVLARSSKSHKWSVFYRLVAGLAITDLLGILLTSPVVLAVYASN-FEWDGGQPLCDYFGFMMsfFGL 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 54635068 110 MDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHIL 161
Cdd:cd14981  89 SSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLL 140
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
33-151 3.21e-08

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 53.74  E-value: 3.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLY------FLCI 106
Cdd:cd15352   9 TLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMdnvfdsMICI 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 54635068 107 FGDMDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVV 151
Cdd:cd15352  89 SLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVV 133
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
36-152 3.78e-08

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 53.36  E-value: 3.78e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKIS--FSGCLTQLYFLCIFGDMdnF 113
Cdd:cd15326  12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGriFCDIWAAVDVLCCTASI--L 89
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15326  90 SLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLS 128
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
34-152 3.99e-08

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 53.39  E-value: 3.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15321  16 LILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIV 95
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15321  96 HLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIA 134
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
34-231 7.16e-08

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 52.99  E-value: 7.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVD-----VCFSSTTAPNVLANHILGSQKISFSGcltqlYFLCIFG 108
Cdd:cd14993  10 VFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADllvslFCMPLTLLENVYRPWVFGEVLCKAVP-----YLQGVSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 109 DMDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVAnMNCLLHILLMARLSFCADNIIPhffcdvtPLLKLS 188
Cdd:cd14993  85 SASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIA-IIIMLPLLVVYELEEIISSEPG-------TITIYI 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 54635068 189 CSDTHLNELMILTEGAVVMVT----PFVCILISYIHITWAVLRVSSP 231
Cdd:cd14993 157 CTEDWPSPELRKAYNVALFVVlyvlPLLIISVAYSLIGRRLWRRKPP 203
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
34-161 9.67e-08

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 52.60  E-value: 9.67e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGC--LTQLYFLCIFGDMD 111
Cdd:cd15959  10 AILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCelWTSVDVLCVTASIE 89
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 54635068 112 NflLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHIL 161
Cdd:cd15959  90 T--LCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIM 137
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
33-152 1.25e-07

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 51.95  E-value: 1.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISfsgcltqlYFLC-IFGDMD 111
Cdd:cd15064   9 LIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILG--------QVLCdIWISLD 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 54635068 112 NFL-------LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15064  81 VTCctasilhLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLS 128
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
40-237 1.32e-07

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 51.91  E-value: 1.32e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  40 LGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTaPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLLAVMA 119
Cdd:cd14970  16 TGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGL-PFLATSYLLGYWPFGEVMCKIVLSVDAYNMFTSIFCLTVMS 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 120 YDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHIlLMARLsfcadniIPHFFCDVTPLLKLSCSDTHLNELMI 199
Cdd:cd14970  95 VDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVI-IFART-------LQEEGGTISCNLQWPDPPDYWGRVFT 166
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 54635068 200 LTEGAVVMVTPFVCILISYIHITWAvLRVSSPRGGWKA 237
Cdd:cd14970 167 IYTFVLGFAVPLLVITVCYSLIIRR-LRSSRNLSTSGA 203
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
33-162 1.47e-07

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 51.71  E-value: 1.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTApnvLANHIL-----------GSQKISFSGCLTQL 101
Cdd:cd15350   9 TIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKT---LENILIiladmgylnrrGPFETKLDDIMDSL 85
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 54635068 102 YFLCIFGDMdnFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILL 162
Cdd:cd15350  86 FCLSLLGSI--FSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGGSGILMILF 144
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
34-152 1.56e-07

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 51.48  E-value: 1.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15322  10 LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIV 89
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15322  90 HLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVIS 128
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
39-152 1.98e-07

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 51.43  E-value: 1.98e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKIS--FSGCLTQLYFLCIFGDMdnFLLA 116
Cdd:cd15325  15 VLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGrvFCNIWAAVDVLCCTASI--MSLC 92
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 54635068 117 VMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15325  93 IISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLS 128
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
33-152 2.19e-07

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 51.28  E-value: 2.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15050   9 TISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASI 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15050  89 FSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLS 128
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
36-152 2.68e-07

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 51.11  E-value: 2.68e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15307  12 LGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIMHL 91
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15307  92 CTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLS 128
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
33-296 2.87e-07

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 50.82  E-value: 2.87e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGC---LTQLYFLCifgd 109
Cdd:cd15061   8 LAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCdfwISLDVLLC---- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 110 MDNFL-LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMArlsfcadniiPHFFCDVTpllklS 188
Cdd:cd15061  84 TASILnLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPS----------WHGRRGLG-----S 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 189 CSDTHLNELMILTeGAVVMVTPFVCILISYIHITWAVLRVSsprggwKAFSTCGshlTVVCLFYGT----VITVYFNPST 264
Cdd:cd15061 149 CYYTYDKGYRIYS-SMGSFFLPLLLMLFVYLRIFRVIAKER------KTAKTLA---IVVGCFIVCwlpfFIMYLIEPFC 218
                       250       260       270
                ....*....|....*....|....*....|...
gi 54635068 265 SYSAGRDTAAAVMYT-VVTPMLNPFIYSLRNRD 296
Cdd:cd15061 219 DCQFSEALSTAFTWLgYFNSVINPFIYAFYNKD 251
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
36-160 3.31e-07

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 51.02  E-value: 3.31e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGC--LTQLYFLCIFGDMDNf 113
Cdd:cd15957  12 LAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCefWTSIDVLCVTASIET- 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 54635068 114 lLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHI 160
Cdd:cd15957  91 -LCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPI 136
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
36-162 3.59e-07

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 50.57  E-value: 3.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15054  12 LLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASILNL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILL 162
Cdd:cd15054  92 CVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIEL 138
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
36-225 6.40e-07

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 49.88  E-value: 6.40e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTaPNVLANHILGSQKISFSGCltQLYFLC--IFGDMDNF 113
Cdd:cd15079  12 IVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKM-PIFIYNSFYEGWALGPLGC--QIYAFLgsLSGIGSIW 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRyTTKMTHQVCALLVMGSWVVANMNCLLhillmaRLSFCADNIIPHFFCDvtpllklSCS--- 190
Cdd:cd15079  89 TNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWALL------PLLFGWGRYVPEGFLT-------SCSfdy 154
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 54635068 191 --DTHLNELMILTEGAVVMVTPFVCILISYIHITWAV 225
Cdd:cd15079 155 ltRDWNTRSFVATIFVFAYVIPLIIIIYCYSFIVKAV 191
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
36-152 6.56e-07

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 49.79  E-value: 6.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKIS--FSGCLTQLYFLCIFGDMdnF 113
Cdd:cd15062  12 LFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGriFCDVWAAVDVLCCTASI--M 89
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15062  90 SLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLS 128
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
34-152 1.11e-06

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 49.10  E-value: 1.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDV-----CFSSTTAPNVLANHILGSqkisfSGCLTQLYFLCIFG 108
Cdd:cd15978  10 IFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLmlclfCMPFTLIPNLLKDFIFGS-----AVCKTATYFMGISV 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 54635068 109 DMDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15978  85 SVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLS 128
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
36-152 1.26e-06

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 49.16  E-value: 1.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNvlanhilgSQKISFSGCLTQLYFLC-IFGDMDNFL 114
Cdd:cd15314  12 LVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPP--------SMVRSVETCWYFGDLFCkIHSSFDITL 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 54635068 115 -------LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15314  84 ctasilnLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVS 128
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
33-161 1.46e-06

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 48.75  E-value: 1.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILG-------SQKISFSGCLTQLYFLC 105
Cdd:cd15353   9 TLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNgndtdaqSFTVNIDNVIDSVICSS 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 54635068 106 IFGDMDNFLlaVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHIL 161
Cdd:cd15353  89 LLASICSLL--SIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVLFII 142
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
39-232 1.55e-06

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 48.78  E-value: 1.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDsRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSG-----CLTQLYFLCIFGDMDNF 113
Cdd:cd14978  15 IIGNILNLVVLTRK-SMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYfyayfLPYIYPLANTFQTASVW 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFCDVTPLLKLSCSDTH 193
Cdd:cd14978  94 LTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLRQNETYLLK 173
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 54635068 194 lneLMILTEGAVVMVTPFVCILISYIHITWAVLRVSSPR 232
Cdd:cd14978 174 ---YYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRR 209
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
33-157 1.57e-06

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 48.38  E-value: 1.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVD--VCFSsttapNVLANHILgsqKISF----SGCLTQLY-FLC 105
Cdd:cd15196   9 TILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADllVALF-----NVLPQLIW---DITYrfygGDLLCRLVkYLQ 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 54635068 106 IFGdM--DNFLLAVMAYDRFVAICHPLRYtTKMTHQVCALLVMGSWVVANMNCL 157
Cdd:cd15196  81 VVG-MyaSSYVLVATAIDRYIAICHPLSS-HRWTSRRVHLMVAIAWVLSLLLSI 132
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
36-157 1.63e-06

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 48.49  E-value: 1.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15059  12 LLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCL 157
Cdd:cd15059  92 CAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISL 133
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
34-154 1.74e-06

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 48.66  E-value: 1.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDV-----CFSSTTAPNVLANHILGSqkisfSGCLTQLYFLCIFG 108
Cdd:cd15979  10 IFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLmlavfCMPFTLIPNLMGTFIFGE-----VICKAVAYLMGVSV 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 54635068 109 DMDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANM 154
Cdd:cd15979  85 SVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGL 130
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
36-152 2.34e-06

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 48.04  E-value: 2.34e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd17790  12 LVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNL 91
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd17790  92 LIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLIS 128
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
39-152 2.40e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 48.19  E-value: 2.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCltQLY-FLCIFGDMDNF-LLA 116
Cdd:cd15073  15 TISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGC--QWYaFLNIFFGMASIgLLT 92
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 54635068 117 VMAYDRFVAICHPLRYtTKMTHQVCALLVMGSWVVA 152
Cdd:cd15073  93 VVAVDRYLTICRPDLG-RKMTTNTYTVMILLAWTNA 127
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
36-152 2.77e-06

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 47.69  E-value: 2.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQ-KISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15052  12 IATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGVwPLPLVLCLLWVTLDVLFCTASIMH 91
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15052  92 LCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLIS 129
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
36-298 2.88e-06

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 48.01  E-value: 2.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLAnhILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15068  12 VLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANM----------NCLLHILLMARLSFCADNIIPHFFCDVTPLl 185
Cdd:cd15068  90 LAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAigltpmlgwnNCGQPKEGKNHSQGCGEGQVACLFEDVVPM- 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 186 klscsdthlnELMILTEGAVVMVTPFVCILISYIHITWAVLRV-----SSPRGGWKAFSTCGSH------------LTVV 248
Cdd:cd15068 169 ----------NYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQlkqmeSQPLPGERARSTLQKEvhaakslaiivgLFAL 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 54635068 249 CLFYGTVITVY--FNPSTSYSAGRDTAAAVMYTVVTPMLNPFIYSLRNRDMK 298
Cdd:cd15068 239 CWLPLHIINCFtfFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFR 290
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
36-152 3.02e-06

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 47.56  E-value: 3.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15324  12 LVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSIVHL 91
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15324  92 CAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVIS 128
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
34-152 3.28e-06

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 47.62  E-value: 3.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15323  10 LIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIV 89
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15323  90 HLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLIS 128
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
39-157 4.21e-06

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 47.33  E-value: 4.21e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCltQLYFLC--IFGDMDNFLLA 116
Cdd:cd15083  15 VVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGC--DMYGFSggLFGIMSINTLA 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 54635068 117 VMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCL 157
Cdd:cd15083  93 AIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVL 133
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
36-162 4.73e-06

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 47.20  E-value: 4.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAP-----NVLANHILGSqkiSFSGCLTQLYFLCIFGDM 110
Cdd:cd15958  12 LLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPfgatlVVRGRWLYGS---FFCELWTSVDVLCVTASI 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 54635068 111 DNflLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILL 162
Cdd:cd15958  89 ET--LCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFLPIMM 138
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
38-157 4.88e-06

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 47.04  E-value: 4.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  38 TVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGsqKISFSGCLTQLYF----LCIFGDMDNf 113
Cdd:cd15060  14 TIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLG--KWLFGIHLCQMWLtcdiLCCTASILN- 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 54635068 114 lLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCL 157
Cdd:cd15060  91 -LCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISV 133
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
36-152 5.37e-06

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 47.12  E-value: 5.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15301  12 LVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNL 91
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15301  92 LIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIIS 128
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
39-227 5.81e-06

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 47.21  E-value: 5.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAP-----NVLANHILGSQ--KISFSGCLTQLYFLCifgdmd 111
Cdd:cd15203  15 VVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPftliyTLTKNWPFGSIlcKLVPSLQGVSIFVST------ 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 112 nFLLAVMAYDRFVAICHPLRytTKMTHQVCALLVMGSWVVANMNClLHILLMARLSfcadniipHFFCDVTPLLKLSCSD 191
Cdd:cd15203  89 -LTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLS-LPLAIFQELS--------DVPIEILPYCGYFCTE 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 54635068 192 THLNELMILTEGAVVMVT----PFVCILISYIHItWAVLR 227
Cdd:cd15203 157 SWPSSSSRLIYTISVLVLqfviPLLIISFCYFRI-SLKLR 195
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
36-161 5.96e-06

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 47.10  E-value: 5.96e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15056  12 LLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTASIMHL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 54635068 116 AVMAYDRFVAIC-HPLRYttKMTHQVCALLVMGSWVVANMNCLLHIL 161
Cdd:cd15056  92 CCIALDRYYAICcQPLVY--KMTPLRVAVMLGGCWVIPTFISFLPIM 136
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
37-152 6.01e-06

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 47.25  E-value: 6.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  37 ATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQ-KISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15217  13 VSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAwTYSVLSCKIVAFMAVLFCFHAAFML 92
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15217  93 FCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLS 129
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
36-162 6.40e-06

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 46.94  E-value: 6.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHIlgSQKISFSGCLTQLY-----FLCIFGDM 110
Cdd:cd15051  12 LLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYEL--RGEWPLGPVFCNIYisldvMLCTASIL 89
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 54635068 111 DNFLLAVmayDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILL 162
Cdd:cd15051  90 NLFAISL---DRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIHL 138
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
33-152 8.14e-06

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 46.50  E-value: 8.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15297   9 SLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASV 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15297  89 MNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLS 128
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
36-152 8.41e-06

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 46.44  E-value: 8.41e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKIS--FSGCLTQLYFLCIFGDMdnF 113
Cdd:cd15327  12 LMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGrvFCDIWAAVDVLCCTASI--L 89
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15327  90 SLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSS 128
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
36-152 8.51e-06

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 46.48  E-value: 8.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15299  15 LVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNL 94
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15299  95 LVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVIS 131
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
39-152 1.33e-05

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 45.89  E-value: 1.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLAnHILGSQKISFSGCLTQLYFL----CIFGDMdnFL 114
Cdd:cd15394  15 VVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLA-YAFEPRGWVFGRFMCYFVFLmqpvTVYVSV--FT 91
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 54635068 115 LAVMAYDRFVAICHPLRytTKMTHQVCALLVMGSWVVA 152
Cdd:cd15394  92 LTAIAVDRYYVTVYPLR--RRISRRTCAYIVAAIWLLS 127
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
34-152 1.49e-05

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 45.72  E-value: 1.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGsqKISFSGcltqlyFLC-IFGDMDN 112
Cdd:cd15329  10 IILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSG--YWPFGE------ILCdVWISFDV 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 54635068 113 FL-------LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15329  82 LLctasilnLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLS 128
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
34-131 1.92e-05

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 45.46  E-value: 1.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVD-----VCFSSTTAPNVLANHILGSQKisfsgCLTQLYFLCIFG 108
Cdd:cd15206  10 IFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDlllavFCMPFTLVGQLLRNFIFGEVM-----CKLIPYFQAVSV 84
                        90       100
                ....*....|....*....|...
gi 54635068 109 DMDNFLLAVMAYDRFVAICHPLR 131
Cdd:cd15206  85 SVSTFTLVAISLERYFAICHPLK 107
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
36-152 2.68e-05

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 44.79  E-value: 2.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15333  16 LATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSSDITCCTASILHL 95
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15333  96 CVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVIS 132
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
36-152 3.87e-05

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 44.23  E-value: 3.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQL---YFLCIFGDMDn 112
Cdd:cd15049  12 LVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLaldYVASNASVMN- 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 54635068 113 flLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15049  91 --LLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVIS 128
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
36-152 4.62e-05

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 44.26  E-value: 4.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSqKISFSGcltqlyFLC-IFGDMDN-- 112
Cdd:cd15053  12 LLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGG-KWYLGP------ILCdIYIAMDVmc 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 54635068 113 -----FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15053  85 stasiFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVS 129
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
39-150 4.72e-05

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 44.32  E-value: 4.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCltQLYFLC--IFGDMDNFLLA 116
Cdd:cd15336  15 MLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGC--ELYAFCgaLFGITSMITLL 92
                        90       100       110
                ....*....|....*....|....*....|....
gi 54635068 117 VMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWV 150
Cdd:cd15336  93 AISLDRYLVITKPLASIRWVSKKRAMIIILLVWL 126
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
33-152 4.91e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 44.15  E-value: 4.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQ-KISFSGCLTQLYFLCIFGDMD 111
Cdd:cd15304   9 IVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRwPLPSKLCAVWIYLDVLFSTAS 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 54635068 112 NFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15304  89 IMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTIS 129
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
39-150 5.48e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 44.23  E-value: 5.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTA-PNVLANHILGSQKISFSGCltQLYFLC--IFGDMDNFLL 115
Cdd:cd15337  15 VIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGfPLKTISSFNKKWIWGKVAC--ELYGFAggIFGFMSITTL 92
                        90       100       110
                ....*....|....*....|....*....|....*
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWV 150
Cdd:cd15337  93 AAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWL 127
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
36-152 6.04e-05

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 43.94  E-value: 6.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15393  12 LVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSVFTL 91
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 116 AVMAYDRFVAICHPLRytTKMTHQVCALLVMGSWVVA 152
Cdd:cd15393  92 TVIAVDRYRAVIHPLK--ARCSKKSAKIIILIIWILA 126
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
35-233 6.53e-05

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 43.59  E-value: 6.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15012  10 FCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASIGI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNiiphffcdVTPLLKLSCSDTHL 194
Cdd:cd15012  90 LVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQ--------DGQEEEICVLDREM 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 54635068 195 NELMILTEGAVVM--VTPFVCILISYIHITWAVLRVSSPRG 233
Cdd:cd15012 162 FNSKLYDTINFIVwyLIPLLIMTVLYSKISIVLWKSSSIEA 202
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
36-150 7.00e-05

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 43.52  E-value: 7.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNvlanhilgSQKISFSGCLTQLYFLC-IFGDMDNFL 114
Cdd:cd15066  11 LAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTF--------NASVEITGRWMFGYFMCdVWNSLDVYF 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 54635068 115 -------LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWV 150
Cdd:cd15066  83 stasilhLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWI 125
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
33-151 7.13e-05

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 43.43  E-value: 7.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGC--LTQLYFLCIFGDM 110
Cdd:cd15330   9 TLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCdlFIALDVLCCTSSI 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 54635068 111 dnFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVV 151
Cdd:cd15330  89 --LHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLI 127
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
34-152 8.30e-05

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 43.45  E-value: 8.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMY-FFLCSLSFVDVCFSSTTAPNVLANHILGSQKI-SFSGCLTQLYFLCIFGDMD 111
Cdd:cd15320  11 LILSTLLGNTLVCAAVIRFRHLRSKVTnFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFgSFCNIWVAFDIMCSTASIL 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 54635068 112 NflLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15320  91 N--LCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLS 129
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
36-152 9.29e-05

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 43.30  E-value: 9.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPnvLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15071  12 LVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAIIINIGPQTEFYSCLMVACPVLILTQSSILAL 89
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15071  90 LAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILS 126
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
36-152 1.10e-04

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 43.09  E-value: 1.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15300  12 LITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASVMNL 91
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15300  92 LVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLIS 128
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
36-152 1.12e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 43.23  E-value: 1.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPnvLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15070  12 LCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFTHASIMSL 89
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15070  90 LAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVS 126
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
41-152 1.23e-04

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 43.15  E-value: 1.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  41 GNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLLAVMAY 120
Cdd:cd15208  17 GNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSVSVSVLTLSCIAL 96
                        90       100       110
                ....*....|....*....|....*....|..
gi 54635068 121 DRFVAICHPLRYttKMTHQVCALLVMGSWVVA 152
Cdd:cd15208  97 DRWYAICHPLMF--KSTAKRARVSILIIWIVS 126
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
36-152 1.24e-04

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 42.99  E-value: 1.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15335  12 ILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSILHL 91
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15335  92 CVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTIS 128
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
34-152 1.53e-04

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 42.68  E-value: 1.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQL---YFLCIfgdM 110
Cdd:cd15048  10 LILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLvvdYTLCT---A 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 54635068 111 DNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15048  87 SALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILA 128
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
33-160 1.73e-04

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 42.47  E-value: 1.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSST----TAPNVLANHILGSQKISFSGCLTQLYFLCIFG 108
Cdd:cd15351   9 FLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSnlieTLFMLLLEHGVLVCRAPMLQHMDNVIDTMICS 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 54635068 109 DMDNFL--LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHI 160
Cdd:cd15351  89 SVVSSLsfLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFI 142
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
36-150 2.15e-04

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 42.15  E-value: 2.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15316  12 VLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVSFCYASLFHL 91
                        90       100       110
                ....*....|....*....|....*....|....*
gi 54635068 116 AVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWV 150
Cdd:cd15316  92 CFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWI 126
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
33-152 2.18e-04

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 41.93  E-value: 2.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15298   9 SLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15298  89 MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLS 128
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
33-132 2.72e-04

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 42.10  E-value: 2.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNV--LIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDM 110
Cdd:cd15142   9 VMFIFGVVGNLiaIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTCLASPVTIATYLKGRWPGGQPLCEYFSFILLFFSLS 88
                        90       100
                ....*....|....*....|..
gi 54635068 111 DNFLLAVMAYDRFVAICHPLRY 132
Cdd:cd15142  89 GLSIICAMSIERYLAINHAYFY 110
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
33-160 3.58e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 41.71  E-value: 3.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTtapNVLAnHILGSQKISFSG----CLTQLYF--LCI 106
Cdd:cd15386   9 AILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALF---QVLP-QLIWEITYRFQGpdllCRAVKYLqvLSM 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 54635068 107 FGDmdNFLLAVMAYDRFVAICHPLRYTTKMTHQVCaLLVMGSWVVAnmnCLLHI 160
Cdd:cd15386  85 FAS--TYMLIMMTVDRYIAVCHPLRTLQQPSRQAY-LMIGATWLLS---CILSL 132
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
36-162 4.15e-04

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 41.22  E-value: 4.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVD-VCFSSTTAPNVLANHILGSQKI-SFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd14995  12 GVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADlMVLVAAGLPNEIESLLGPDSWIyGYAGCLLITYLQYLGINASSL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 54635068 114 LLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILL 162
Cdd:cd14995  92 SITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFL 140
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
37-229 4.38e-04

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 41.43  E-value: 4.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  37 ATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLLA 116
Cdd:cd15081  25 ASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVSVCGITGLWSLT 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 117 VMAYDRFVAICHPLRyTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLsfcadniIPHFfcdvtplLKLSC------- 189
Cdd:cd15081 105 IISWERWVVVCKPFG-NIKFDGKLAIVGIIFSWVWSAVWCAPPIFGWSRY-------WPHG-------LKTSCgpdvfsg 169
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 54635068 190 -SDTHLNELMIltegaVVMVT----PFVCILISYIHITWAVLRVS 229
Cdd:cd15081 170 sSDPGVQSYMI-----VLMITcciiPLAIIILCYLQVWLAIRAVA 209
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
33-225 4.70e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 41.19  E-value: 4.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAP-NVLANHILgsQKISFSGCLTQL--YFLCIFGD 109
Cdd:cd15392   9 TIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPfSFIALLIL--QYWPFGEFMCPVvnYLQAVSVF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 110 MDNFLLAVMAYDRFVAICHPLRytTKMTHQVCALLVMGSWVVAnMNCLLHILLMARLsfcadnIIPHFFCDVTPLLKLSC 189
Cdd:cd15392  87 VSAFTLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFA-LATALPIAITSRL------FEDSNASCGQYICTESW 157
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 54635068 190 SDTHLNELMILTEGAVVMVTPFVCILISYIHITWAV 225
Cdd:cd15392 158 PSDTNRYIYSLVLMILQYFVPLAVLVFTYTRIGIVV 193
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
36-156 4.80e-04

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 40.94  E-value: 4.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGC---LTQLYFLCIFGDMDn 112
Cdd:cd15063  12 VLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCqiwLAVDVWMCTASILN- 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 54635068 113 flLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNC 156
Cdd:cd15063  91 --LCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVIC 132
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
39-150 5.47e-04

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 40.89  E-value: 5.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSST--TAPNVLANHILGSQKISFSGCLTQLYFLCIFgdmdnFLLA 116
Cdd:cd15905  13 IFANLFIILGIACNRKLHNTANYFFLSLLLADLLTGVAlpFIPGMSNESRRGYHSCLFVYVAPNFLFLSFL-----ANLL 87
                        90       100       110
                ....*....|....*....|....*....|....
gi 54635068 117 VMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWV 150
Cdd:cd15905  88 MVHYERYLCIVYPLQYHNFWVHRWVPLALLLTWA 121
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
33-165 5.85e-04

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 40.92  E-value: 5.85e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSsTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15094   9 LICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFL-IGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSS 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 54635068 113 FLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVAnMNCLLHILLMAR 165
Cdd:cd15094  88 FTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSIS-FLVMLPIILYAS 139
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
34-146 5.95e-04

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 40.99  E-value: 5.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLG---NVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDM 110
Cdd:cd15085   7 MFLNATFSifnNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIV 86
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 54635068 111 DNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVM 146
Cdd:cd15085  87 SLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLF 122
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
39-131 6.35e-04

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 40.72  E-value: 6.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGC--LTQLYFLCIFGDMdnFLLA 116
Cdd:cd15001  14 LIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCkaVAYLQLLSFICSV--LTLT 91
                        90
                ....*....|....*
gi 54635068 117 VMAYDRFVAICHPLR 131
Cdd:cd15001  92 AISIERYYVILHPMK 106
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
34-152 6.49e-04

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 40.66  E-value: 6.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVC----------FSSTTApNVLANHILGSQkiSFSGCLTqLYF 103
Cdd:cd15136  10 VFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCmgiylgllaiVDAKTL-GEYYNYAIDWQ--TGAGCKT-AGF 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 54635068 104 LCIFG-DMDNFLLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15136  86 LAVFSsELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFA 135
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-152 6.72e-04

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 40.60  E-value: 6.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSsttAPNVLANHILGSQKISFSG---CLTQLYFLCIFGDMDN 112
Cdd:cd16004  12 LVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMA---AFNTAFNFVYASHNDWYFGlefCRFQNFFPITAMFVSI 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 54635068 113 FLLAVMAYDRFVAICHPLRytTKMTHQVCALLVMGSWVVA 152
Cdd:cd16004  89 YSMTAIAADRYMAIIHPFK--PRLSAGSTKVVIAGIWLVA 126
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
37-152 6.82e-04

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 40.60  E-value: 6.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  37 ATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHI--LGSQKISFSGCLTQLYFLCIFGDMDNfl 114
Cdd:cd15215  12 ASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVplFWPLDSHLCTALVVLMHLFAFAGVNT-- 89
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15215  90 IVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVS 127
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
39-132 1.20e-03

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 39.89  E-value: 1.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLA-----NHILGSQKISFSGCLTQlyfLCIFGDMdnF 113
Cdd:cd15401  15 VLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLaifhnGWTLGNIHCQISGFLMG---LSVIGSV--F 89
                        90
                ....*....|....*....
gi 54635068 114 LLAVMAYDRFVAICHPLRY 132
Cdd:cd15401  90 NITAIAINRYCYICHSLRY 108
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
43-149 1.22e-03

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 39.75  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  43 VLIILAISTDSRLHTPMyFFLCSLSFVDVCFSSTTAPNVLANHILGSQkiSFSGCLTQLY-FLCIFGDMDNFL-LAVMAY 120
Cdd:cd15219  20 VLLCFLYSAELRKQVPG-IFLLNLSFCNLLLTVLNMPFTLLGVVRNRQ--PFGDGFCQAVgFLETFLTSNAMLsMAALSI 96
                        90       100
                ....*....|....*....|....*....
gi 54635068 121 DRFVAICHPLRYTTKMTHQVCALLVMGSW 149
Cdd:cd15219  97 DRWIAVVFPLSYTSKMRYRDAALMVGYSW 125
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
38-168 1.39e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 40.02  E-value: 1.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  38 TVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDN-FLLA 116
Cdd:cd15218  14 SVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFTSVKNGSTWTYGTLTCKVIAFLGVLSCFHTaFMLF 93
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 54635068 117 VMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSF 168
Cdd:cd15218  94 CISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSF 145
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
34-150 1.42e-03

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 39.82  E-value: 1.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNF 113
Cdd:cd15008   9 LWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIY 88
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 114 LLAVMAYDRFVAICHPLRYttKMTHQVCALLVMGSWV 150
Cdd:cd15008  89 VLLSICVDRFYTIVYPLSF--KVSREKAKKMIAASWL 123
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
36-152 1.77e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 39.43  E-value: 1.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQ-KISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15308  12 LAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFQGGVwTLSPVLCDALMTMDVMLCTASIFN 91
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15308  92 LCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILS 129
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
38-152 1.86e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 39.33  E-value: 1.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  38 TVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCfssTTAPNVLANHIL---GSQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15197  14 IVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLC---VGLINVLTDIIWritVEWRAGDFACKVIRYLQVVVTYASTYV 90
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 54635068 115 LAVMAYDRFVAICHPLRYTTkmTHQVCALLVMGSWVVA 152
Cdd:cd15197  91 LVALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILS 126
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
34-152 1.94e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 39.48  E-value: 1.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLanHILGSQKISFSGCLTQLYFL----CIFGD 109
Cdd:cd15131  10 LFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLY--RLWQYRPWNFGDLLCKLFQFvsesCTYST 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 54635068 110 MDNflLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15131  88 ILN--ITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVS 128
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
34-301 2.08e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 39.05  E-value: 2.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLH-TPMYFFLCSLSFVDVCFSSTTAPNVLANHIlgsqkisFSGCLTQLYFLCIFGDMDN 112
Cdd:cd15341  10 CGLLCILENVAVLYLILSSPKLRrKPSYLFIGSLALADFLASVVFACSFVDFHV-------FHGVDSSAIFLLKLGGVTM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 113 FLLA------VMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVAnmncllhiLLMARLSFCADNIIPhffcdvtplLK 186
Cdd:cd15341  83 SFTAslgsllLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLT--------ALIAYLPLMGWNCCP---------LN 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 187 LSCSDTH-LNELMILTEGAVVMVTPFVCILISYIHITW---------------AVLRVSSPRGGWKAFSTCGSHLTVVCL 250
Cdd:cd15341 146 SPCSELFpLIPNDYLLSWLLLVAILLSGIIYTYGHVLWkahkhvvymekhqdqQGPGNARMRLDVRLAKTLGLVLAVLLI 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 54635068 251 FYGTVITVYFNP---STSYSAGRDTAAAVMYTVVTPMLNPFIYSLRNRDMKVAL 301
Cdd:cd15341 226 CWSPVLALMMHSlftSLSDHIKKAFAFCSTLCLVNSMVNPIIYALRSRELRSSL 279
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-165 2.11e-03

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 39.14  E-value: 2.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVDvcfSSTTAPNVLANHILGSQKISFSG---CLTQLYF--LCIFGDMdnF 113
Cdd:cd16003  15 VFGNLIVIWIILAHKRMRTVTNYFLVNLAFSD---ASMAAFNTLINFIYALHSEWYFGeayCRFHNFFpiTSVFASI--Y 89
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 54635068 114 LLAVMAYDRFVAICHPL--RYTTKMTHQVCALLVMGSWVVANMNCLLHILLMAR 165
Cdd:cd16003  90 SMTAIAVDRYMAIIDPLkpRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMP 143
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
39-151 2.29e-03

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 38.79  E-value: 2.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLLAVM 118
Cdd:cd15210  15 VPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLI 94
                        90       100       110
                ....*....|....*....|....*....|...
gi 54635068 119 AYDRFVAICHPLRYTTKMTHQVCALLVMGSWVV 151
Cdd:cd15210  95 TLNRYILIAHPSLYPRIYTRRGLALMIAGTWIF 127
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
33-152 2.42e-03

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 39.00  E-value: 2.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  33 TMYLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGC---LTQLYFLCifgD 109
Cdd:cd15296   9 LLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCklwLVVDYLLC---T 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 54635068 110 MDNFLLAVMAYDRFVAICHPLRYTTK--MTHQVCALLVMgSWVVA 152
Cdd:cd15296  86 ASVFNIVLISYDRFLSVTRAVSYRAQkgMTRQAVLKMVL-VWVLA 129
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
39-150 2.53e-03

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 38.97  E-value: 2.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFssTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDM--DNFLLA 116
Cdd:cd15088  15 LVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLF--MLGMPFLIHQFAIDGQWYFGEVMCKIITALDANNQftSTYILT 92
                        90       100       110
                ....*....|....*....|....*....|....
gi 54635068 117 VMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWV 150
Cdd:cd15088  93 AMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWA 126
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
40-157 2.55e-03

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 38.77  E-value: 2.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  40 LGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLLAVMA 119
Cdd:cd15214  15 LGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIA 94
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 54635068 120 YDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCL 157
Cdd:cd15214  95 IDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCL 132
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
41-152 3.23e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 38.64  E-value: 3.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  41 GNVLIILAISTDSRLHTPMYFFLCSLSFVDVcfssTTAPNVLANHILGSQKISFSG----CLTQLYFLCIFGDMDNFLLA 116
Cdd:cd15387  17 GNICVLLAIHTTRHKHSRMYFFMKHLSIADL----VVAVFQVLPQLIWDITFRFYGpdflCRLVKYLQVVGMFASTYMLL 92
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 54635068 117 VMAYDRFVAICHPLRYTTKMTHQVcalLVMGSWVVA 152
Cdd:cd15387  93 LMSIDRCLAICQPLRSLHRRSDRV---YVLFSWLLS 125
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
36-152 3.48e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 38.35  E-value: 3.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILG-SQKISFSGCLTQLYFLCIFGDMDNFL 114
Cdd:cd15305  12 ILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDyAWPLPRYLCPIWISLDVLFSTASIMH 91
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 54635068 115 LAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVA 152
Cdd:cd15305  92 LCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTIS 129
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
34-221 3.54e-03

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 38.40  E-value: 3.54e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  34 MYLATVLGNVLIILAISTDSRLHTPMY-FFLCSLSFVDVCFSSTTAPNVLANHILGSQKI-SFSGCLTQLYFLCIFGDMD 111
Cdd:cd15319  10 LILWTLLGNILVCAAVVRFRHLRSKVTnIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFgAFCDVWVAFDIMCSTASIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 112 NflLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPHFFcDVTPLLKLSCsD 191
Cdd:cd15319  90 N--LCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVQLNWHKDSGDDWVGLHNS-SISRQVEENC-D 165
                       170       180       190
                ....*....|....*....|....*....|
gi 54635068 192 THLNELMILTEGAVVMVTPFVCILISYIHI 221
Cdd:cd15319 166 SSLNRTYAISSSLISFYIPVAIMIVTYTRI 195
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
39-151 5.09e-03

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 38.05  E-value: 5.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLLAVM 118
Cdd:cd15096  15 LIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLM 94
                        90       100       110
                ....*....|....*....|....*....|...
gi 54635068 119 AYDRFVAICHPLRYTTKMTHQVCALLVMGSWVV 151
Cdd:cd15096  95 SLDRYLAVVHPITSMSIRTERNTLIAIVGIWIV 127
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
54-234 7.35e-03

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 37.44  E-value: 7.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  54 RLHTPMYFFLCSLSFVDVCFSSTTAPNV--LANHI--LGSQKISFSGCLTQ--LYFLCIFgdmdnflLAVMAYDRFVAIC 127
Cdd:cd15154  30 RLHSVVSIYMCNLALSDLLFTLSLPLRIyyYANHYwpFGNFLCQFSGSIFQmnMYGSCLF-------LMCINVDRYLAIV 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068 128 HPLRYTTKMTHQVCALLVMGSWVVANMNClLHILLMARLSFCADNIIPHFFCdvtpllKLSCSDTHLNELMILTEGAVVM 207
Cdd:cd15154 103 HPLRFRHLRRPKVARLLCLAVWALILGGS-VPAAIVHSSSDCLLHGEKVYRC------FESFSDNDWKGLLPLVVLAEIL 175
                       170       180
                ....*....|....*....|....*....
gi 54635068 208 --VTPFVCILISYIHITWAVLRVSSPRGG 234
Cdd:cd15154 176 gfLLPLAAVLYCSCRIFVELCRTQEPQQG 204
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
39-132 8.09e-03

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 37.19  E-value: 8.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068    39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVD-VCFSSTTapnVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLLAV 117
Cdd:pfam10320   5 LFGNVLMIHLTFRKKKLRSKCSILICVQCIAHlICLCGEI---VFVVLLFTGTQLTRNECFWMISFYIFGQTAQGPLMLM 81
                          90
                  ....*....|....*
gi 54635068   118 MAYDRFVAICHPLRY 132
Cdd:pfam10320  82 IGIDRLIAVKFPIFY 96
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
39-153 8.14e-03

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 37.24  E-value: 8.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  39 VLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVcFSSTTAPNVLANHILGSQkiSFSGCLTQLYFLCIFGDM--DNFLLA 116
Cdd:cd15089  15 LLGNVLVMYGIVRYTKMKTATNIYIFNLALADA-LATSTLPFQSAKYLMETW--PFGELLCKAVLSIDYYNMftSIFTLT 91
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 54635068 117 VMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVAN 153
Cdd:cd15089  92 MMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSS 128
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
36-159 8.73e-03

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 37.32  E-value: 8.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  36 LATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHILGSQKISFSGCLTQLYFLCIFGDMDNFLL 115
Cdd:cd15389  12 VISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVSTLTL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 54635068 116 AVMAYDRFVAICHPLRytTKMTHQVCALLVMGSWVVANMNCLLH 159
Cdd:cd15389  92 TAIALDRHRVILHPLK--PRITPCQGVVVIAIIWIMASCLSLPH 133
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
35-176 9.87e-03

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 36.95  E-value: 9.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54635068  35 YLATVLGNVLIILAISTDSRLHTPMYFFLCSLSFVDVCFSSTTAPNVLANHI-LGSQKISFSGC-LTQLYF-LCIFGDMD 111
Cdd:cd14979  11 FVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWwQYPWAFGDGGCkLYYFLFeACTYATVL 90
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 54635068 112 NflLAVMAYDRFVAICHPLRYTTKMTHQVCALLVMGSWVVANMNCLLHILLMARLSFCADNIIPH 176
Cdd:cd14979  91 T--IVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYLNGPLPGPV 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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