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Conserved domains on  [gi|93352558|ref|NP_001005498|]
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inactive rhomboid protein 2 isoform 2 [Homo sapiens]

Protein Classification

inactive rhomboid protein( domain architecture ID 10576411)

inactive rhomboid protein regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation; does not exhibit any protease activity on its own

CATH:  1.20.1540.10
MEROPS:  S54
PubMed:  21439629|22035660|24099005
SCOP:  4000471

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rhomboid_SP pfam12595
Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 ...
 99-282 4.05e-103

Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.


:

Pssm-ID: 463639  Cd Length: 193  Bit Score: 316.43  E-value: 4.05e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558    99 VSGDWEGQrQQWQRRSLHHCSMRYGRLKASCQRDLELPSQEAPSFQGTESPKPCKMPK-------IVDPLARGRAFRHPE 171
Cdd:pfam12595   1 VSKDSDST-QRWQRKSLRHCSMRYGKLKPQVIREMELPSQDNPSLTSTETPPPLYLPKshhgmqrIVDPLARGRAFRMVE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558   172 EMDRPHAPHPPLTPGVLSLTSFTSVRSGYSHLP-RRKRMSVAHMSLQAAAALLKGRSVLDATGQRCRvvKRSFAFPSFLE 250
Cdd:pfam12595  80 EVDGYSVPQTPITPGVASLCSFTSSRSGLNRLPrRRKRESVAKMSFRAAAALMKGRSLRESTLRRRR--RRSFTPPSFLE 157

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 93352558   251 EDVVDGADTFDSSFFSK----EEMSSMPDDVFESPP 282
Cdd:pfam12595 158 EDTVDFADELDTSFFSKddlhEELSSMADEVFESPS 193
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 619-762 7.29e-33

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


:

Pssm-ID: 426384  Cd Length: 147  Bit Score: 123.87  E-value: 7.29e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558   619 PEVPDQFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLPY-RAEVGPAGSQFG 697
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 93352558   698 LLACLFVELFQSWPLLERPWKAFLNLSAIVLFLFICGLLPW--IDNIAHIFGFLSGLLLAFAFLPYI 762
Cdd:pfam01694  81 LLGALLVLGPRNRILLFGLIGALLALLLFILLNLVLGLLPGngVSNLAHLGGLLVGLLLGFILLRRP 147
SWEET super family cl46783
Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism]; ...
 745-804 1.61e-03

Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG4095:

Pssm-ID: 481123  Cd Length: 83  Bit Score: 38.25  E-value: 1.61e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 93352558 745 IFGFLSGLLLAFAFLP-----YITFGTSDkyrkralilVSLLAFAGLFAALVLWLyIYPI---NWPWI 804
Cdd:COG4095   5 IIGLLAGILTTISFLPqviktWKTKSTKD---------ISLGMYLIFTTGVALWL-IYGIligDLPII 62
 
Name Accession Description Interval E-value
Rhomboid_SP pfam12595
Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 ...
 99-282 4.05e-103

Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.


Pssm-ID: 463639  Cd Length: 193  Bit Score: 316.43  E-value: 4.05e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558    99 VSGDWEGQrQQWQRRSLHHCSMRYGRLKASCQRDLELPSQEAPSFQGTESPKPCKMPK-------IVDPLARGRAFRHPE 171
Cdd:pfam12595   1 VSKDSDST-QRWQRKSLRHCSMRYGKLKPQVIREMELPSQDNPSLTSTETPPPLYLPKshhgmqrIVDPLARGRAFRMVE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558   172 EMDRPHAPHPPLTPGVLSLTSFTSVRSGYSHLP-RRKRMSVAHMSLQAAAALLKGRSVLDATGQRCRvvKRSFAFPSFLE 250
Cdd:pfam12595  80 EVDGYSVPQTPITPGVASLCSFTSSRSGLNRLPrRRKRESVAKMSFRAAAALMKGRSLRESTLRRRR--RRSFTPPSFLE 157

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 93352558   251 EDVVDGADTFDSSFFSK----EEMSSMPDDVFESPP 282
Cdd:pfam12595 158 EDTVDFADELDTSFFSKddlhEELSSMADEVFESPS 193
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 619-762 7.29e-33

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 123.87  E-value: 7.29e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558   619 PEVPDQFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLPY-RAEVGPAGSQFG 697
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 93352558   698 LLACLFVELFQSWPLLERPWKAFLNLSAIVLFLFICGLLPW--IDNIAHIFGFLSGLLLAFAFLPYI 762
Cdd:pfam01694  81 LLGALLVLGPRNRILLFGLIGALLALLLFILLNLVLGLLPGngVSNLAHLGGLLVGLLLGFILLRRP 147
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 624-760 3.71e-20

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 89.15  E-value: 3.71e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558 624 QFYRLWLSLFLHAGVVHclvsVVFQMTIL----RDLEKLAGWHRIAIIFILSGITGNLASAIFLPYRAE--VGPAGSQFG 697
Cdd:COG0705  42 ELWRLLTSMFLHGGFLH----LLFNMLALwvfgPLLERRLGSKRFLLLYLLSGLGGGLLQLLFSPGSGYplVGASGAIFG 117

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 93352558 698 LLACLFV-ELFQSWPLLERPWKAFLNLSAIVLFLFICGLLPW--IDNIAHIFGFLSGLLLAFAFLP 760
Cdd:COG0705 118 LLGALLVlGPRRRVLLLFIPIPALLFLLVWLLLGLLFGLLGGggIAWEAHLGGLLAGLLLALLLRK 183
PTZ00101 PTZ00101
rhomboid-1 protease; Provisional
 624-758 1.72e-11

rhomboid-1 protease; Provisional


Pssm-ID: 185445  Cd Length: 278  Bit Score: 65.64  E-value: 1.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558  624 QFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNL--ASAIFLPYRaeVGPAGSQFGLLAC 701
Cdd:PTZ00101 101 EIHRLILPIFLHANIFHTFFNVFFQLRMGFTLEKNYGIVKIIILYFLTGIYGNIlsSSVTYCPIK--VGASTSGMGLLGI 178

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 93352558  702 LFVELFQSWPLLERPWKAFLNlsaIVLFLFICGLLPW------IDNIAHIFGFLSGLLLAFAF 758
Cdd:PTZ00101 179 VTSELILLWHVIRHRERVVFN---IIFFSLISFFYYFtfngsnIDHVGHLGGLLSGISMGILY 238
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 720-804 1.94e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.53  E-value: 1.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558 720 FLNLSAIVLFLFICGLLpwidnIAHIFG--FLSGLLLAFAFLPYITFGT-----SDKYRKRALILVSLLAFAGLFAALVL 792
Cdd:cd06173   9 LLSALGDWIFTVALPWL-----VLQLTGsaLLVGLVLAAFFLPFLLFSPfagvlADRFDRRRLLILADLLRALLAAVLAL 83

                        90
                ....*....|..
gi 93352558 793 WLYIYPINWPWI 804
Cdd:cd06173  84 LALLGSLSLWLL 95
SWEET COG4095
Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism]; ...
 745-804 1.61e-03

Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism];


Pssm-ID: 443271  Cd Length: 83  Bit Score: 38.25  E-value: 1.61e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 93352558 745 IFGFLSGLLLAFAFLP-----YITFGTSDkyrkralilVSLLAFAGLFAALVLWLyIYPI---NWPWI 804
Cdd:COG4095   5 IIGLLAGILTTISFLPqviktWKTKSTKD---------ISLGMYLIFTTGVALWL-IYGIligDLPII 62
rhom_GG_sort TIGR03902
rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like ...
 624-756 7.00e-03

rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like intramembrane serine protease. Its species distribution closely matches model TIGR03501, GlyGly-CTERM, which describes a protein targeting domain analogous to LPXTG and PEP-CTERM. In a number of species (Ralstonia eutropha ,R. metallidurans, R. solanacearum, Marinobacter aquaeolei, etc) with just one GlyGly-CTERM protein (i.e., a dedicated system), the rhombosortase and GlyGly-CTERM genes are adjacent.


Pssm-ID: 274845  Cd Length: 154  Bit Score: 37.94  E-value: 7.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558   624 QFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLP-YRAEVGPAGSQFGLLA-C 701
Cdd:TIGR03902  15 EWWRLLTGHFVHLNWWHLLMNLAGLLLLWALFGRHLRARRLLLLLLLLSLLISLGLLLFLPsLQWYVGLSGVLHGLFAwG 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 93352558   702 LFVELFQSwplLERPWKAFLNLSAIVLFLFICG----LLPWIDN----IAHIFGFLSGLLLAF 756
Cdd:TIGR03902  95 ALRDIRYG---RRSGWLLLLGVIAKLAWEQLFGasafTAALIGApvatEAHLAGAISGLLIAL 154
 
Name Accession Description Interval E-value
Rhomboid_SP pfam12595
Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 ...
 99-282 4.05e-103

Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.


Pssm-ID: 463639  Cd Length: 193  Bit Score: 316.43  E-value: 4.05e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558    99 VSGDWEGQrQQWQRRSLHHCSMRYGRLKASCQRDLELPSQEAPSFQGTESPKPCKMPK-------IVDPLARGRAFRHPE 171
Cdd:pfam12595   1 VSKDSDST-QRWQRKSLRHCSMRYGKLKPQVIREMELPSQDNPSLTSTETPPPLYLPKshhgmqrIVDPLARGRAFRMVE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558   172 EMDRPHAPHPPLTPGVLSLTSFTSVRSGYSHLP-RRKRMSVAHMSLQAAAALLKGRSVLDATGQRCRvvKRSFAFPSFLE 250
Cdd:pfam12595  80 EVDGYSVPQTPITPGVASLCSFTSSRSGLNRLPrRRKRESVAKMSFRAAAALMKGRSLRESTLRRRR--RRSFTPPSFLE 157

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 93352558   251 EDVVDGADTFDSSFFSK----EEMSSMPDDVFESPP 282
Cdd:pfam12595 158 EDTVDFADELDTSFFSKddlhEELSSMADEVFESPS 193
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 619-762 7.29e-33

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 123.87  E-value: 7.29e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558   619 PEVPDQFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLPY-RAEVGPAGSQFG 697
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 93352558   698 LLACLFVELFQSWPLLERPWKAFLNLSAIVLFLFICGLLPW--IDNIAHIFGFLSGLLLAFAFLPYI 762
Cdd:pfam01694  81 LLGALLVLGPRNRILLFGLIGALLALLLFILLNLVLGLLPGngVSNLAHLGGLLVGLLLGFILLRRP 147
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 624-760 3.71e-20

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 89.15  E-value: 3.71e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558 624 QFYRLWLSLFLHAGVVHclvsVVFQMTIL----RDLEKLAGWHRIAIIFILSGITGNLASAIFLPYRAE--VGPAGSQFG 697
Cdd:COG0705  42 ELWRLLTSMFLHGGFLH----LLFNMLALwvfgPLLERRLGSKRFLLLYLLSGLGGGLLQLLFSPGSGYplVGASGAIFG 117

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 93352558 698 LLACLFV-ELFQSWPLLERPWKAFLNLSAIVLFLFICGLLPW--IDNIAHIFGFLSGLLLAFAFLP 760
Cdd:COG0705 118 LLGALLVlGPRRRVLLLFIPIPALLFLLVWLLLGLLFGLLGGggIAWEAHLGGLLAGLLLALLLRK 183
PTZ00101 PTZ00101
rhomboid-1 protease; Provisional
 624-758 1.72e-11

rhomboid-1 protease; Provisional


Pssm-ID: 185445  Cd Length: 278  Bit Score: 65.64  E-value: 1.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558  624 QFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNL--ASAIFLPYRaeVGPAGSQFGLLAC 701
Cdd:PTZ00101 101 EIHRLILPIFLHANIFHTFFNVFFQLRMGFTLEKNYGIVKIIILYFLTGIYGNIlsSSVTYCPIK--VGASTSGMGLLGI 178

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 93352558  702 LFVELFQSWPLLERPWKAFLNlsaIVLFLFICGLLPW------IDNIAHIFGFLSGLLLAFAF 758
Cdd:PTZ00101 179 VTSELILLWHVIRHRERVVFN---IIFFSLISFFYYFtfngsnIDHVGHLGGLLSGISMGILY 238
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
659-804 7.12e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.05  E-value: 7.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558 659 AGWHRIAIIFILSGITGNLASAIFLPYRaeVGPAGSQFGLLAcLFVELFQSwpllerpwKAFLNLSAIVLFLFICGLLPW 738
Cdd:COG2211 180 LGYRLTALIFAVLGLLAFLLTFFGTKER--PVPEEEKVSLKE-SLKALLKN--------RPFLLLLLAYLLFFLALALVA 248

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 93352558 739 ----------IDNIAHIFGFLSGLLLAFAFLPYITFGT-SDKYRKRALILVSLLafagLFAALVLWLYIYPINWPWI 804
Cdd:COG2211 249 alllyyfkyvLGLSAALVGLLLALYFLAALLGAPLWPRlAKRFGKKKAFIIGLL----LAALGLLLLFFLGPGNLWL 321
MFS_1 pfam07690
Major Facilitator Superfamily;
658-804 8.92e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.49  E-value: 8.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558   658 LAGWHriaIIFILSGITGNLASAIFL-----PYRAEVGPAGSQFGLLACLFVELFQSWPLLerPWKAFLNLSAIVLFLFI 732
Cdd:pfam07690 147 LFGWR---AAFLILAILSLLAAVLLLlprppPESKRPKPAEEARLSLIVAWKALLRDPVLW--LLLALLLFGFAFFGLLT 221

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 93352558   733 cgLLPWIDNIAHIFGFLSGLLLAFAFLPYITFG-----TSDKYRKRALILVSLLAFAGLFAALVLWLYIYPINWPWI 804
Cdd:pfam07690 222 --YLPLYQEVLGLSALLAGLLLGLGGLLGAIGRlllgrLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLL 296
GtrA pfam04138
GtrA-like protein; Members of this family are predicted to be integral membrane proteins with ...
 719-803 1.83e-04

GtrA-like protein; Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.


Pssm-ID: 427738  Cd Length: 116  Bit Score: 41.77  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558   719 AFLNLSAIVLFLFICGLLPWIdniAHIFGFLSGLLLAFAFLPYITFGTSDKYRKRAL---ILVSLLAFAGLFAALVLWLY 795
Cdd:pfam04138  10 TLVDLAVFLLLLELFGLSYLL---ANAIAFVVAILVNFLLNRRWTFRDRRSGSLRELlrfFLVSLAGLLLNLLLLWLLVD 86


                  ....*...
gi 93352558   796 IYPINWPW 803
Cdd:pfam04138  87 GLGLPPLL 94
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 720-804 1.94e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.53  E-value: 1.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558 720 FLNLSAIVLFLFICGLLpwidnIAHIFG--FLSGLLLAFAFLPYITFGT-----SDKYRKRALILVSLLAFAGLFAALVL 792
Cdd:cd06173   9 LLSALGDWIFTVALPWL-----VLQLTGsaLLVGLVLAAFFLPFLLFSPfagvlADRFDRRRLLILADLLRALLAAVLAL 83

                        90
                ....*....|..
gi 93352558 793 WLYIYPINWPWI 804
Cdd:cd06173  84 LALLGSLSLWLL 95
SWEET COG4095
Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism]; ...
 745-804 1.61e-03

Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism];


Pssm-ID: 443271  Cd Length: 83  Bit Score: 38.25  E-value: 1.61e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 93352558 745 IFGFLSGLLLAFAFLP-----YITFGTSDkyrkralilVSLLAFAGLFAALVLWLyIYPI---NWPWI 804
Cdd:COG4095   5 IIGLLAGILTTISFLPqviktWKTKSTKD---------ISLGMYLIFTTGVALWL-IYGIligDLPII 62
SpoIIE COG5817
Stage II sporulation protein SpoIIE/SpoIIH (serine phosphatase - sigma-F activation) [Cell ...
 626-790 1.72e-03

Stage II sporulation protein SpoIIE/SpoIIH (serine phosphatase - sigma-F activation) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444519 [Multi-domain]  Cd Length: 803  Bit Score: 42.18  E-value: 1.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558 626 YRLWLSLFLHAGVV-----HCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGnLASAIF-LPYRAEVGPAGSQF--- 696
Cdd:COG5817  75 RALLVLLGALLGYLtlgggSALFKYLAALLLFLLLSKFLKRKKKKKILVLPLLVF-LSVLVVgLVYLAFGGGSPYDLlma 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558 697 ---GLLACLFVELF-QSWPLL-ERPWKAFLN----LSAIVLF-LFICGLLPWID---NIAHIFGFLSGLLLAFA------ 757
Cdd:COG5817 154 lfeAILAFVLTYIFlQALPLLtEKRKRKSLTneeiICLLILLaSVLTGLGGLTIgglSLKNILSRLLVLLAAYIggaglg 233

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 93352558 758 --------FLPYITFGTSdkyrkraLILVSLLAFAGLFAAL 790
Cdd:COG5817 234 aavgvvigLILSLSNGSS-------PYMIGLYAFAGLLAGL 267
TgpA_N pfam11992
TgpA N-terminal domain; This domain can be found at the N terminus of TgpA from Pseudomonas ...
 628-794 5.11e-03

TgpA N-terminal domain; This domain can be found at the N terminus of TgpA from Pseudomonas aeruginosa. TgpA is a transglutaminase that plays a critical role in the viability of Pseudomonas aeruginosa. This domain is composed of 5 transmembrane helices.


Pssm-ID: 463423  Cd Length: 336  Bit Score: 40.11  E-value: 5.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558   628 LWLSLFLHAGVVhCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLPYRAEVGPAGSqfGLLACLFVELF 707
Cdd:pfam11992  19 WWVPALLLVALV-LAVGALLRRLRLPRWRLPPALLLAGLLVLALLLTLFLAGTALLGLSLGLLAAVA--LLLLALLLKLL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558   708 QSWplLERPWKAFLNLSAIVL---FLFICGLLPWIdniaHIFGFLSGLLLAFAFLPYITFGTSDKYRKRALILVSLLAFA 784
Cdd:pfam11992  96 EVR--LRRDALAGLLLLLFLLvpaALLSQSLGLLL----FLLLALAFLLLLLVDLRDRSRTPPGRRLRGLLRTAARLGLV 169

                         170
                  ....*....|
gi 93352558   785 GLFAALVLWL 794
Cdd:pfam11992 170 ALPLALVLFL 179
VKOR_3 cd12920
Vitamin K epoxide reductase family in bacteria; This family includes vitamin K epoxide ...
 663-795 6.67e-03

Vitamin K epoxide reductase family in bacteria; This family includes vitamin K epoxide reductase (VKOR) present in proteobacteria and spirochetes. VKOR (also named VKORC1) is an integral membrane protein that catalyzes the reduction of vitamin K 2,3-epoxide and vitamin K to vitamin K hydroquinone, an essential co-factor subsequently used in the gamma-carboxylation of glutamic acid residues in blood coagulation enzymes. All homologs of VKOR contain an active site CXXC motif, which is switched between reduced and disulfide-bonded states during the reaction cycle. In some bacterial homologs, the VKOR domain is fused with domains of the thioredoxin family of oxidoreductases which may function as redox partners in initiating the reduction cascade.


Pssm-ID: 240603  Cd Length: 134  Bit Score: 37.67  E-value: 6.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558 663 RIAIIFILSGItGNLASAIFLPYRAEVGPAGSQFgllaCLFVELFQSWPLLERPWKAFLNLsaivlflficgllPwidnI 742
Cdd:cd12920   1 AIALVLALIGL-AFSGLLTYHHYGILTDGVGSSF----CAINEVVNCDKVAQSPYSAIGGV-------------P----I 58

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 93352558 743 AhIFGFLSGLLLAFAFLpyiTFGTSDKYRKRALILVSLLAFAGLFAALVLWLY 795
Cdd:cd12920  59 A-LWGLLAYGFLAALFL---LALISREDSERAAGLLFLVLLVGLVADLVLGLI 107
rhom_GG_sort TIGR03902
rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like ...
 624-756 7.00e-03

rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like intramembrane serine protease. Its species distribution closely matches model TIGR03501, GlyGly-CTERM, which describes a protein targeting domain analogous to LPXTG and PEP-CTERM. In a number of species (Ralstonia eutropha ,R. metallidurans, R. solanacearum, Marinobacter aquaeolei, etc) with just one GlyGly-CTERM protein (i.e., a dedicated system), the rhombosortase and GlyGly-CTERM genes are adjacent.


Pssm-ID: 274845  Cd Length: 154  Bit Score: 37.94  E-value: 7.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558   624 QFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLP-YRAEVGPAGSQFGLLA-C 701
Cdd:TIGR03902  15 EWWRLLTGHFVHLNWWHLLMNLAGLLLLWALFGRHLRARRLLLLLLLLSLLISLGLLLFLPsLQWYVGLSGVLHGLFAwG 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 93352558   702 LFVELFQSwplLERPWKAFLNLSAIVLFLFICG----LLPWIDN----IAHIFGFLSGLLLAF 756
Cdd:TIGR03902  95 ALRDIRYG---RRSGWLLLLGVIAKLAWEQLFGasafTAALIGApvatEAHLAGAISGLLIAL 154
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
715-793 9.06e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.19  E-value: 9.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93352558 715 RPWKAFLNLSAIVLFLFICG--LLPWIDNIAHIFG---FLSGLLLAFAFLPYITFGT-----SDKYRKRALILVSLLAFA 784
Cdd:COG2814   7 RRWLALLALALGAFLSGLGIgiVLPALPLIAADLGaspAQAGLVVTAYLLGAALGAPlagrlADRFGRRRVLLLGLLLFA 86


                ....*....
gi 93352558 785 GLFAALVLW 793
Cdd:COG2814  87 LGSLLCALA 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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