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Conserved domains on  [gi|255652928|ref|NP_001005358|]
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zinc finger protein 960 isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 1.85e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 1.85e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 255652928   13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-525 2.89e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 2.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 156 KPYECNQCGKAFARHSNLLDHKRIHTGEKPYKCKQCGKD--FTHHSTLHIHKRIHTREKTYKCNQCMTIAHLQCHKITHT 233
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 234 GE-----KPYACKKCGKTFAYHKTLQIHERTHT---GEKLYQCNQCAKAFP-------------------YHRTLQIHER 286
Cdd:COG5048  112 SSssnsnDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPqsnslhpplpanslskdpsSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 287 THTGEKPYECNQCGKAFACLRNLQNHKTTHTGEKPYECNQCGRAF------RQYVYLQCHERIHTGEKPFECNQCGKAFA 360
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 361 RHSTLQRHKRTHTG-EKPYECNQCGKAFACPRYLQIHKRT--HTGE--KPYEC--NQCGKAFACHRYLQIHKRTHTGERP 433
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 434 YEC--NQCGKAFT------CRSNLQIHKRTHTgERPYEC--NQCGKAFTCRSNLQIHKRTHTGEKPYECN--QCGKAFTQ 501
Cdd:COG5048  352 AKEklLNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                        410       420
                 ....*....|....*....|....
gi 255652928 502 FFPLKRHEITHTKEKPYECNQCGK 525
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 1.85e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 1.85e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 255652928   13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
13-54 7.40e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 80.33  E-value: 7.40e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 255652928    13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIGY 54
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-50 2.59e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 2.59e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 255652928  13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLT 50
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-525 2.89e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 2.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 156 KPYECNQCGKAFARHSNLLDHKRIHTGEKPYKCKQCGKD--FTHHSTLHIHKRIHTREKTYKCNQCMTIAHLQCHKITHT 233
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 234 GE-----KPYACKKCGKTFAYHKTLQIHERTHT---GEKLYQCNQCAKAFP-------------------YHRTLQIHER 286
Cdd:COG5048  112 SSssnsnDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPqsnslhpplpanslskdpsSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 287 THTGEKPYECNQCGKAFACLRNLQNHKTTHTGEKPYECNQCGRAF------RQYVYLQCHERIHTGEKPFECNQCGKAFA 360
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 361 RHSTLQRHKRTHTG-EKPYECNQCGKAFACPRYLQIHKRT--HTGE--KPYEC--NQCGKAFACHRYLQIHKRTHTGERP 433
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 434 YEC--NQCGKAFT------CRSNLQIHKRTHTgERPYEC--NQCGKAFTCRSNLQIHKRTHTGEKPYECN--QCGKAFTQ 501
Cdd:COG5048  352 AKEklLNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                        410       420
                 ....*....|....*....|....
gi 255652928 502 FFPLKRHEITHTKEKPYECNQCGK 525
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
365-389 1.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.24e-04
                          10        20
                  ....*....|....*....|....*
gi 255652928  365 LQRHKRTHTGEKPYECNQCGKAFAC 389
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 1.85e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 1.85e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 255652928   13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
13-54 7.40e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 80.33  E-value: 7.40e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 255652928    13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIGY 54
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-50 2.59e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 2.59e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 255652928  13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLT 50
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-525 2.89e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 2.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 156 KPYECNQCGKAFARHSNLLDHKRIHTGEKPYKCKQCGKD--FTHHSTLHIHKRIHTREKTYKCNQCMTIAHLQCHKITHT 233
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 234 GE-----KPYACKKCGKTFAYHKTLQIHERTHT---GEKLYQCNQCAKAFP-------------------YHRTLQIHER 286
Cdd:COG5048  112 SSssnsnDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPqsnslhpplpanslskdpsSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 287 THTGEKPYECNQCGKAFACLRNLQNHKTTHTGEKPYECNQCGRAF------RQYVYLQCHERIHTGEKPFECNQCGKAFA 360
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 361 RHSTLQRHKRTHTG-EKPYECNQCGKAFACPRYLQIHKRT--HTGE--KPYEC--NQCGKAFACHRYLQIHKRTHTGERP 433
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 434 YEC--NQCGKAFT------CRSNLQIHKRTHTgERPYEC--NQCGKAFTCRSNLQIHKRTHTGEKPYECN--QCGKAFTQ 501
Cdd:COG5048  352 AKEklLNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                        410       420
                 ....*....|....*....|....
gi 255652928 502 FFPLKRHEITHTKEKPYECNQCGK 525
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
131-389 2.04e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 2.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 131 DGNQCGKTFSCHNHFEIRKGTYTGEKPYECNQCGKAFARHSNLLDHKRIHTGEKPYKCKQCG----KDFTHHSTLHIHKR 206
Cdd:COG5048  172 PANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspKSLLSQSPSSLSSS 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 207 IHTREKTYKCNQCMTIAHLQCHKITHTGE-------KPYACKKCGKTFAYHKTLQIHERT--HTGEKLYQC----NQCAK 273
Cdd:COG5048  252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFscpySLCGK 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 274 AFPYHRTLQIHERTHTGEKPYEC--NQCGKAF-----ACLRNLQNHKTTHTGEKPYEC--NQCGRAFRQYVYLQCHERIH 344
Cdd:COG5048  332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 255652928 345 TGEKP--FECNQCGKAFARHSTLQRHKRTHTGEKPYECNQCGKAFAC 389
Cdd:COG5048  412 LSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
128-312 7.24e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 7.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 128 KVYDGNQCGKTFSCHNHFE--IRKGTYTGE--KPYEC--NQCGKAFARHSNLLDHKRIHTGEKPYKCK--QCGKDFT--- 196
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTrhLRSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 197 ---HHSTLHIHKRIHTREKTY----KCNQ-CMTIAHLQCHKITHTGEKPYACKkcgktfayhktlqiherthtgeklyqC 268
Cdd:COG5048  368 nnePPQSLQQYKDLKNDKKSEtlsnSCIRnFKRDSNLSLHIITHLSFRPYNCK--------------------------N 421

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 255652928 269 NQCAKAFPYHRTLQIHERTHTGEKPYECNQCGKAFACLrNLQNH 312
Cdd:COG5048  422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL-DLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
264-542 8.47e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 8.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 264 KLYQCNQCAKAFPYHRTLQIHERTHTGEKPYECNQCGKAFACLRNLQNHKT--THTGEKPYECNQCgraFRQYVYLQCH- 340
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHlrTHHNNPSDLNSKS---LPLSNSKASSs 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 341 ERIHTGEKPFECNQC---GKAFARHSTLQRHKRTHTGEKPYECNQC-GKAFACPRYLQIHKRTHTGEKPYECNQCGKAFA 416
Cdd:COG5048  109 SLSSSSSNSNDNNLLsshSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 417 CHRYLQIHKRTH---------------------TGERPYECNQCGKAFTCRSNLQIHKRTHTGERPYECNQCGKAFTCRS 475
Cdd:COG5048  189 SSNVSTSIPSSSensplsssysipssssdqnleNSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 476 NLQIHKRTHTGE-------KPYECNQCGKAFTQFFPLKRH--EITHTKE--KPYEC--NQCGKAFTRHSTLQIHKRTHTG 542
Cdd:COG5048  269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
365-389 1.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.24e-04
                          10        20
                  ....*....|....*....|....*
gi 255652928  365 LQRHKRTHTGEKPYECNQCGKAFAC 389
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
476-501 3.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 255652928  476 NLQIHKRTHTGEKPYECNQCGKAFTQ 501
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
172-197 5.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 255652928  172 NLLDHKRIHTGEKPYKCKQCGKDFTH 197
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
448-473 6.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.03e-04
                          10        20
                  ....*....|....*....|....*.
gi 255652928  448 NLQIHKRTHTGERPYECNQCGKAFTC 473
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
392-417 6.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 255652928  392 YLQIHKRTHTGEKPYECNQCGKAFAC 417
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 1.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.12e-03
                          10        20
                  ....*....|....*....|....*
gi 255652928  281 LQIHERTHTGEKPYECNQCGKAFAC 305
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
420-445 1.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.15e-03
                          10        20
                  ....*....|....*....|....*.
gi 255652928  420 YLQIHKRTHTGERPYECNQCGKAFTC 445
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
505-529 1.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.22e-03
                          10        20
                  ....*....|....*....|....*
gi 255652928  505 LKRHEITHTKEKPYECNQCGKAFTR 529
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 458-541 3.49e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652928 458 GERPYECN--QCGKAFTCRSNLQIHKRThtgekpyecNQCGKAFTQFFPLKRHEITHTKEKPYECNQCGKAFTRHSTLQI 535
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 255652928 536 HkRTHT 541
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
308-333 3.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.50e-03
                          10        20
                  ....*....|....*....|....*.
gi 255652928  308 NLQNHKTTHTGEKPYECNQCGRAFRQ 333
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-361 5.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.28e-03
                          10        20
                  ....*....|....*....|..
gi 255652928  340 HERIHTGEKPFECNQCGKAFAR 361
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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