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Conserved domains on  [gi|1446500452|ref|NP_001005210|]
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leucine-rich repeat-containing protein 55 precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18784505)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-196 2.17e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 2.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452  47 QVVDCSSQRLFSVPPDLPMDT--RNLSLAHNRITAVPP--GYLTcymELQVLDLHNNSLMELPRGLfLHAKRLAHLDLSY 122
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPEplGNLT---NLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSN 191

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1446500452 123 NNFSHVPADmFQEAHGLVHIDLSHNPwLRRVhPQAFQGLMQLRDLDLSYGGLAflSLEALEGLPGLVTLQIGGN 196
Cdd:COG4886   192 NQITDLPEP-LGNLTNLEELDLSGNQ-LTDL-PEPLANLTNLETLDLSNNQLT--DLPELGNLTNLEELDLSNN 260
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
196-247 1.31e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.95  E-value: 1.31e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1446500452  196 NPWVCGCTMEPLLKWLRNRIQrcTADSQLAECRGPPEVEGaPLFSLTEESFK 247
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEH--LQDPVDLRCASPSSLRG-PLLELLHSEFK 49
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-196 2.17e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 2.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452  47 QVVDCSSQRLFSVPPDLPMDT--RNLSLAHNRITAVPP--GYLTcymELQVLDLHNNSLMELPRGLfLHAKRLAHLDLSY 122
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPEplGNLT---NLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSN 191

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1446500452 123 NNFSHVPADmFQEAHGLVHIDLSHNPwLRRVhPQAFQGLMQLRDLDLSYGGLAflSLEALEGLPGLVTLQIGGN 196
Cdd:COG4886   192 NQITDLPEP-LGNLTNLEELDLSGNQ-LTDL-PEPLANLTNLETLDLSNNQLT--DLPELGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
90-148 9.54e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 9.54e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1446500452  90 ELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNP 148
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-201 3.33e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 3.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452  47 QVVDCSSQRLFSVPPDLPMDTR--NLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLM-ELPRGLFlHAKRLAHLDLSYN 123
Cdd:PLN00113  455 QMLSLARNKFFGGLPDSFGSKRleNLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELS-SCKKLVSLDLSHN 533

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452 124 NFS-HVPADmFQEAHGLVHIDLSHNPWLRRVhPQAFQGLMQLRDLDLS----YGGL----AFLSLEAleglpglvtLQIG 194
Cdd:PLN00113  534 QLSgQIPAS-FSEMPVLSQLDLSQNQLSGEI-PKNLGNVESLVQVNIShnhlHGSLpstgAFLAINA---------SAVA 602


                  ....*..
gi 1446500452 195 GNPWVCG 201
Cdd:PLN00113  603 GNIDLCG 609
LRRNT smart00013
Leucine rich repeat N-terminal domain;
38-69 1.57e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.85  E-value: 1.57e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1446500452   38 CPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRN 69
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRCT smart00082
Leucine rich repeat C-terminal domain;
196-247 1.31e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.95  E-value: 1.31e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1446500452  196 NPWVCGCTMEPLLKWLRNRIQrcTADSQLAECRGPPEVEGaPLFSLTEESFK 247
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEH--LQDPVDLRCASPSSLRG-PLLELLHSEFK 49
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 59-192 3.83e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.49  E-value: 3.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452  59 VPPDLPMDTRNLSLAHNRITAVP----PGYLTCYMELQVLDLHNNSLME-----LPRGLfLHAKRLAHLDLSYNNFSHVP 129
Cdd:cd00116   131 GLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDagiraLAEGL-KANCNLEVLDLNNNGLTDEG 209

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1446500452 130 ADMFQEA----HGLVHIDLSHNPW----LRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEAL-EGLPGLVTLQ 192
Cdd:cd00116   210 ASALAETlaslKSLEVLNLGDNNLtdagAAALASALLSPNISLLTLSLSCNDITDDGAKDLaEVLAEKESLL 281
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-196 2.17e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 2.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452  47 QVVDCSSQRLFSVPPDLPMDT--RNLSLAHNRITAVPP--GYLTcymELQVLDLHNNSLMELPRGLfLHAKRLAHLDLSY 122
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPEplGNLT---NLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSN 191

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1446500452 123 NNFSHVPADmFQEAHGLVHIDLSHNPwLRRVhPQAFQGLMQLRDLDLSYGGLAflSLEALEGLPGLVTLQIGGN 196
Cdd:COG4886   192 NQITDLPEP-LGNLTNLEELDLSGNQ-LTDL-PEPLANLTNLETLDLSNNQLT--DLPELGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-196 1.54e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 1.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452  91 LQVLDLHNNSLMELPRGLFlHAKRLAHLDLSYNNFSHVPADmFQEAHGLVHIDLSHNPwLRRVhPQAFQGLMQLRDLDLS 170
Cdd:COG4886   115 LESLDLSGNQLTDLPEELA-NLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQ-LTDL-PEELGNLTNLKELDLS 190

                          90       100
                  ....*....|....*....|....*.
gi 1446500452 171 YGGLAFLSlEALEGLPGLVTLQIGGN 196
Cdd:COG4886   191 NNQITDLP-EPLGNLTNLEELDLSGN 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-196 1.56e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452  47 QVVDCSSQRLFSVPPDL-PMDT-RNLSLAHNRITAVPP--GYLTcymELQVLDLHNNSLMELPRGLFlHAKRLAHLDLSY 122
Cdd:COG4886   162 KSLDLSNNQLTDLPEELgNLTNlKELDLSNNQITDLPEplGNLT---NLEELDLSGNQLTDLPEPLA-NLTNLETLDLSN 237

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1446500452 123 NNFSHVPAdmFQEAHGLVHIDLSHNpWLRRVHPQAfqGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGN 196
Cdd:COG4886   238 NQLTDLPE--LGNLTNLEELDLSNN-QLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR_8 pfam13855
Leucine rich repeat;
90-148 9.54e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 9.54e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1446500452  90 ELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNP 148
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-201 3.33e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 3.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452  47 QVVDCSSQRLFSVPPDLPMDTR--NLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLM-ELPRGLFlHAKRLAHLDLSYN 123
Cdd:PLN00113  455 QMLSLARNKFFGGLPDSFGSKRleNLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELS-SCKKLVSLDLSHN 533

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452 124 NFS-HVPADmFQEAHGLVHIDLSHNPWLRRVhPQAFQGLMQLRDLDLS----YGGL----AFLSLEAleglpglvtLQIG 194
Cdd:PLN00113  534 QLSgQIPAS-FSEMPVLSQLDLSQNQLSGEI-PKNLGNVESLVQVNIShnhlHGSLpstgAFLAINA---------SAVA 602


                  ....*..
gi 1446500452 195 GNPWVCG 201
Cdd:PLN00113  603 GNIDLCG 609
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
25-166 4.24e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 4.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452  25 LAAGLMH----SDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPgylTCYMELQVLDLHNNS 100
Cdd:PRK15370  302 LPSGITHlnvqSNSLTALPETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPE---TLPPTITTLDVSRNA 378

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1446500452 101 LMELPRGLflhAKRLAHLDLSYNNFSHVPADM---FQEAHGLVHIDLSHNPWLRRVhPQAFQGLMQLRD 166
Cdd:PRK15370  379 LTNLPENL---PAALQIMQASRNNLVRLPESLphfRGEGPQPTRIIVEYNPFSERT-IQNMQRLMSSVG 443
LRR_8 pfam13855
Leucine rich repeat;
68-125 2.77e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 2.77e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1446500452  68 RNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNF 125
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-197 3.67e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 3.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452  90 ELQVLDLHNNSLMElprglflHAKRLAHLDLSYNNFSHVPADmFQEAHGLVHIDLSHNPwLRRVhPQAFQGLMQLRDLDL 169
Cdd:COG4886    97 NLTELDLSGNEELS-------NLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQ-LTDL-PEPLGNLTNLKSLDL 166

                          90       100
                  ....*....|....*....|....*...
gi 1446500452 170 SYGGLAFLSlEALEGLPGLVTLQIGGNP 197
Cdd:COG4886   167 SNNQLTDLP-EELGNLTNLKELDLSNNQ 193
LRR_8 pfam13855
Leucine rich repeat;
138-197 1.06e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.06e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452 138 GLVHIDLSHNPwLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNP 197
Cdd:pfam13855   2 NLRSLDLSNNR-LTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRRNT smart00013
Leucine rich repeat N-terminal domain;
38-69 1.57e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.85  E-value: 1.57e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1446500452   38 CPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRN 69
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
36-132 1.60e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.31  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452  36 TSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPgylTCYMELQVLDLHNNSLMELPRGLflhAKRL 115
Cdd:PRK15370  233 TSIPATLPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPE---NLPEELRYLSVYDNSIRTLPAHL---PSGI 306

                          90
                  ....*....|....*..
gi 1446500452 116 AHLDLSYNNFSHVPADM 132
Cdd:PRK15370  307 THLNVQSNSLTALPETL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-224 1.03e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.47  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452  39 PVLCTCRN-QVVDCSSQRLFSVPPDLPMDT--RNLSLAHNRITAVPP-GYLTcymELQVLDLHNNSLMELPRGLFLhaKR 114
Cdd:COG4886   199 EPLGNLTNlEELDLSGNQLTDLPEPLANLTnlETLDLSNNQLTDLPElGNLT---NLEELDLSNNQLTDLPPLANL--TN 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452 115 LAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIG 194
Cdd:COG4886   274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLL 353

                         170       180       190
                  ....*....|....*....|....*....|
gi 1446500452 195 GNPWVCGCTMEPLLKWLRNRIQRCTADSQL 224
Cdd:COG4886   354 LLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 38-64 9.50e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 38.76  E-value: 9.50e-05
                          10        20
                  ....*....|....*....|....*..
gi 1446500452  38 CPVLCTCRNQVVDCSSQRLFSVPPDLP 64
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRCT smart00082
Leucine rich repeat C-terminal domain;
196-247 1.31e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.95  E-value: 1.31e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1446500452  196 NPWVCGCTMEPLLKWLRNRIQrcTADSQLAECRGPPEVEGaPLFSLTEESFK 247
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEH--LQDPVDLRCASPSSLRG-PLLELLHSEFK 49
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
53-215 1.41e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.15  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452  53 SQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCymeLQVLDLHNNSLMELPRGLflhAKRLAHLDLSYNNFSHVPADM 132
Cdd:PRK15370  229 SNQLTSIPATLPDTIQEMELSINRITELPERLPSA---LQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHL 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452 133 fqeAHGLVHIDLSHNpwlrrvhpqafqglmqlrdldlsygglaflSLEAL-EGLP-GLVTLQIGGNPWVC-GCTMEPLLK 209
Cdd:PRK15370  303 ---PSGITHLNVQSN------------------------------SLTALpETLPpGLKTLEAGENALTSlPASLPPELQ 349


                  ....*....
gi 1446500452 210 WL---RNRI 215
Cdd:PRK15370  350 VLdvsKNQI 358
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 59-192 3.83e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.49  E-value: 3.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452  59 VPPDLPMDTRNLSLAHNRITAVP----PGYLTCYMELQVLDLHNNSLME-----LPRGLfLHAKRLAHLDLSYNNFSHVP 129
Cdd:cd00116   131 GLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDagiraLAEGL-KANCNLEVLDLNNNGLTDEG 209

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1446500452 130 ADMFQEA----HGLVHIDLSHNPW----LRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEAL-EGLPGLVTLQ 192
Cdd:cd00116   210 ASALAETlaslKSLEVLNLGDNNLtdagAAALASALLSPNISLLTLSLSCNDITDDGAKDLaEVLAEKESLL 281
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-170 5.97e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 5.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446500452  68 RNLSLAHNRITAV-----PPGYLTCYMELQVLDLhNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVpaDMFQEAHGLVHI 142
Cdd:cd21340    71 KKLYLGGNRISVVeglenLTNLEELHIENQRLPP-GEKLTFDPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQL 147

                          90       100       110
                  ....*....|....*....|....*....|
gi 1446500452 143 DLSHNPwLRRVHP--QAFQGLMQLRDLDLS 170
Cdd:cd21340   148 DASNNQ-ISDLEEllDLLSSWPSLRELDLT 176
LRR smart00370
Leucine-rich repeats, outliers;
90-111 8.41e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.09  E-value: 8.41e-03
                           10        20
                   ....*....|....*....|..
gi 1446500452   90 ELQVLDLHNNSLMELPRGLFLH 111
Cdd:smart00370   3 NLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
90-111 8.41e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 33.09  E-value: 8.41e-03
                           10        20
                   ....*....|....*....|..
gi 1446500452   90 ELQVLDLHNNSLMELPRGLFLH 111
Cdd:smart00369   3 NLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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