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Conserved domains on  [gi|51871603|ref|NP_001004102|]
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suppressor of tumorigenicity 7 protein [Rattus norvegicus]

Protein Classification

ST7 domain-containing protein( domain architecture ID 11148215)

ST7 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ST7 pfam04184
ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour ...
18-553 0e+00

ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene. The molecular function of this protein is uncertain.


:

Pssm-ID: 461214  Cd Length: 532  Bit Score: 1006.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603    18 WSWTYLWTVWFFLVLFLVYILRVPLRINDNLSTVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVS 97
Cdd:pfam04184   2 WSWTYLWLIWLLLVAVLLYYLRGPLRLSENLNAVTVFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603    98 VSHLRPLLGGvdnnssNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFT 177
Cdd:pfam04184  82 LNHLSPLIGG------GDNASDNGENEENRQSVPECKVWRNPLNLFRGAEYNRYLWVTGREPLTYYDMNLSAQDHQTFFT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603   178 CDSDHLRPADAIMQKAWRERNPQARISAAHEALEIN-ECATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQH 256
Cdd:pfam04184 156 CDTDSGRPADEIMQKAWRERNPQARIKAAHQALEINpDCATALVLLAEEEAETISDAEKLLRQALKAGESNYRKSQQSQH 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603   257 HGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYD 336
Cdd:pfam04184 236 LSSNHEAQHRRDTNVLVYIKRRLAMCARKLGRTKEAVKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYD 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603   337 DISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDS 416
Cdd:pfam04184 316 DISLPKSATICYTAALLKARAVCDKFSPESASKRGLSTAEMTAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDS 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603   417 EAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFT 496
Cdd:pfam04184 396 EAVAYAFFHLQHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPSCTENADRELLPSFHEVSVYPKKELPFFILFT 475
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 51871603   497 AGLCSFTAMLALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVESILPSSLWHQLTR 553
Cdd:pfam04184 476 AGLCSFTAMLALLTHQFPEPMGAFAKTFLGWLSAPFSFMVEKLESIIPANIWHQLTR 532
 
Name Accession Description Interval E-value
ST7 pfam04184
ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour ...
18-553 0e+00

ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene. The molecular function of this protein is uncertain.


Pssm-ID: 461214  Cd Length: 532  Bit Score: 1006.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603    18 WSWTYLWTVWFFLVLFLVYILRVPLRINDNLSTVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVS 97
Cdd:pfam04184   2 WSWTYLWLIWLLLVAVLLYYLRGPLRLSENLNAVTVFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603    98 VSHLRPLLGGvdnnssNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFT 177
Cdd:pfam04184  82 LNHLSPLIGG------GDNASDNGENEENRQSVPECKVWRNPLNLFRGAEYNRYLWVTGREPLTYYDMNLSAQDHQTFFT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603   178 CDSDHLRPADAIMQKAWRERNPQARISAAHEALEIN-ECATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQH 256
Cdd:pfam04184 156 CDTDSGRPADEIMQKAWRERNPQARIKAAHQALEINpDCATALVLLAEEEAETISDAEKLLRQALKAGESNYRKSQQSQH 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603   257 HGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYD 336
Cdd:pfam04184 236 LSSNHEAQHRRDTNVLVYIKRRLAMCARKLGRTKEAVKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYD 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603   337 DISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDS 416
Cdd:pfam04184 316 DISLPKSATICYTAALLKARAVCDKFSPESASKRGLSTAEMTAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDS 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603   417 EAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFT 496
Cdd:pfam04184 396 EAVAYAFFHLQHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPSCTENADRELLPSFHEVSVYPKKELPFFILFT 475
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 51871603   497 AGLCSFTAMLALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVESILPSSLWHQLTR 553
Cdd:pfam04184 476 AGLCSFTAMLALLTHQFPEPMGAFAKTFLGWLSAPFSFMVEKLESIIPANIWHQLTR 532
ST7 cd11557
Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor ...
54-518 0e+00

Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor in human cancer cells. It appears to localize to the cytoplasm and plasma membrane, and may mediate tumor suppression by regulating genes that are involved in oncogenic pathways and/or maintain cellular structure. It has been suggested that the suppression of tumorigenicity is associated with a function in mediating the remodeling of the extracellular matrix. However, somatic mutations of ST7 have not been observed as being commonly associated with molecular pathogenesis in various human neoplasias.


Pssm-ID: 211407 [Multi-domain]  Cd Length: 458  Bit Score: 957.61  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603  54 FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSsngdsdsnRQSVSEC 133
Cdd:cd11557   1 FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSLSHLSPLLGGVDLSNGGSNSS--------DQSVPEC 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603 134 KVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEIN 213
Cdd:cd11557  73 KVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDADAGRPADEIMQKAWRERNPQARIKAAHEALELN 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603 214 -ECATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREA 292
Cdd:cd11557 153 pECATALILLAEEEAQTILEAEKLLKQALKAAEANYRKSQQLQHQDPQHEAVHRRDTNVLVYIKRRLAMCARKLGRLKEA 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603 293 VKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASRRGL 372
Cdd:cd11557 233 VKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVADKFSPEVASRRGL 312
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603 373 STAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPY 452
Cdd:cd11557 313 STAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWKRVEGALNLLHCTWEGTFRMIPY 392
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 51871603 453 PLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMG 518
Cdd:cd11557 393 PLEKGHLFYPYPSCTESADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTALLALLTHQFPEPMG 458
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
195-307 5.71e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.02  E-value: 5.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603 195 RERNPQARISAAHEALEIN-ECATAYILLAEEEATT--IAEAEKLFKQALKAGDGC----------YRRSQQLQHHGSQY 261
Cdd:COG2956 122 QEGDWEKAIEVLERLLKLGpENAHAYCELAELYLEQgdYDEAIEALEKALKLDPDCarallllaelYLEQGDYEEAIAAL 201
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 51871603 262 EAQHRRDTNVLVYIkRRLAMCARRLGRTREAVKMMRDLMKEFPLLS 307
Cdd:COG2956 202 ERALEQDPDYLPAL-PRLAELYEKLGDPEEALELLRKALELDPSDD 246
 
Name Accession Description Interval E-value
ST7 pfam04184
ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour ...
18-553 0e+00

ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene. The molecular function of this protein is uncertain.


Pssm-ID: 461214  Cd Length: 532  Bit Score: 1006.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603    18 WSWTYLWTVWFFLVLFLVYILRVPLRINDNLSTVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVS 97
Cdd:pfam04184   2 WSWTYLWLIWLLLVAVLLYYLRGPLRLSENLNAVTVFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603    98 VSHLRPLLGGvdnnssNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFT 177
Cdd:pfam04184  82 LNHLSPLIGG------GDNASDNGENEENRQSVPECKVWRNPLNLFRGAEYNRYLWVTGREPLTYYDMNLSAQDHQTFFT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603   178 CDSDHLRPADAIMQKAWRERNPQARISAAHEALEIN-ECATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQH 256
Cdd:pfam04184 156 CDTDSGRPADEIMQKAWRERNPQARIKAAHQALEINpDCATALVLLAEEEAETISDAEKLLRQALKAGESNYRKSQQSQH 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603   257 HGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYD 336
Cdd:pfam04184 236 LSSNHEAQHRRDTNVLVYIKRRLAMCARKLGRTKEAVKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYD 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603   337 DISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDS 416
Cdd:pfam04184 316 DISLPKSATICYTAALLKARAVCDKFSPESASKRGLSTAEMTAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDS 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603   417 EAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFT 496
Cdd:pfam04184 396 EAVAYAFFHLQHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPSCTENADRELLPSFHEVSVYPKKELPFFILFT 475
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 51871603   497 AGLCSFTAMLALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVESILPSSLWHQLTR 553
Cdd:pfam04184 476 AGLCSFTAMLALLTHQFPEPMGAFAKTFLGWLSAPFSFMVEKLESIIPANIWHQLTR 532
ST7 cd11557
Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor ...
54-518 0e+00

Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor in human cancer cells. It appears to localize to the cytoplasm and plasma membrane, and may mediate tumor suppression by regulating genes that are involved in oncogenic pathways and/or maintain cellular structure. It has been suggested that the suppression of tumorigenicity is associated with a function in mediating the remodeling of the extracellular matrix. However, somatic mutations of ST7 have not been observed as being commonly associated with molecular pathogenesis in various human neoplasias.


Pssm-ID: 211407 [Multi-domain]  Cd Length: 458  Bit Score: 957.61  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603  54 FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSsngdsdsnRQSVSEC 133
Cdd:cd11557   1 FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSLSHLSPLLGGVDLSNGGSNSS--------DQSVPEC 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603 134 KVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEIN 213
Cdd:cd11557  73 KVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDADAGRPADEIMQKAWRERNPQARIKAAHEALELN 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603 214 -ECATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREA 292
Cdd:cd11557 153 pECATALILLAEEEAQTILEAEKLLKQALKAAEANYRKSQQLQHQDPQHEAVHRRDTNVLVYIKRRLAMCARKLGRLKEA 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603 293 VKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASRRGL 372
Cdd:cd11557 233 VKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVADKFSPEVASRRGL 312
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603 373 STAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPY 452
Cdd:cd11557 313 STAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWKRVEGALNLLHCTWEGTFRMIPY 392
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 51871603 453 PLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMG 518
Cdd:cd11557 393 PLEKGHLFYPYPSCTESADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTALLALLTHQFPEPMG 458
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
195-307 5.71e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.02  E-value: 5.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51871603 195 RERNPQARISAAHEALEIN-ECATAYILLAEEEATT--IAEAEKLFKQALKAGDGC----------YRRSQQLQHHGSQY 261
Cdd:COG2956 122 QEGDWEKAIEVLERLLKLGpENAHAYCELAELYLEQgdYDEAIEALEKALKLDPDCarallllaelYLEQGDYEEAIAAL 201
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 51871603 262 EAQHRRDTNVLVYIkRRLAMCARRLGRTREAVKMMRDLMKEFPLLS 307
Cdd:COG2956 202 ERALEQDPDYLPAL-PRLAELYEKLGDPEEALELLRKALELDPSDD 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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