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Conserved domains on  [gi|145966853|ref|NP_001003910|]
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tetratricopeptide repeat protein 41 isoform 3 [Mus musculus]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 336-443 3.40e-03

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member pfam13401:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 129  Bit Score: 38.86  E-value: 3.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145966853   336 KSILLLSGERGCGKSTLIANWVSNFQSKHPGVLMIpyfvgsTC-ESCDIMSVIHYFVMELQHRANGPRLEMDFLNedsnv 414
Cdd:pfam13401    5 AGILVLTGESGTGKTTLLRRLLEQLPEVRDSVVFV------DLpSGTSPKDLLRALLRALGLPLSGRLSKEELLA----- 73

                           90       100
                   ....*....|....*....|....*....
gi 145966853   415 lvfslLVEVFIAAISLKPCiLVLDGIEEL 443
Cdd:pfam13401   74 -----ALQQLLLALAVAVV-LIIDEAQHL 96
 
Name Accession Description Interval E-value
AAA_22 pfam13401
AAA domain;
336-443 3.40e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 38.86  E-value: 3.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145966853   336 KSILLLSGERGCGKSTLIANWVSNFQSKHPGVLMIpyfvgsTC-ESCDIMSVIHYFVMELQHRANGPRLEMDFLNedsnv 414
Cdd:pfam13401    5 AGILVLTGESGTGKTTLLRRLLEQLPEVRDSVVFV------DLpSGTSPKDLLRALLRALGLPLSGRLSKEELLA----- 73

                           90       100
                   ....*....|....*....|....*....
gi 145966853   415 lvfslLVEVFIAAISLKPCiLVLDGIEEL 443
Cdd:pfam13401   74 -----ALQQLLLALAVAVV-LIIDEAQHL 96
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 336-443 4.05e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 39.28  E-value: 4.05e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145966853    336 KSILLLSGERGCGKSTLIANWVSNFQSKHPGVLmipyfvgstcescdimsvihYFVMELQHRANGPRLEMDFLNEDSNVL 415
Cdd:smart00382    2 GEVILIVGPPGSGKTTLARALARELGPPGGGVI--------------------YIDGEDILEEVLDQLLLIIVGGKKASG 61

                            90       100
                    ....*....|....*....|....*....
gi 145966853    416 VFSLLVEVFIA-AISLKPCILVLDGIEEL 443
Cdd:smart00382   62 SGELRLRLALAlARKLKPDVLILDEITSL 90
 
Name Accession Description Interval E-value
AAA_22 pfam13401
AAA domain;
336-443 3.40e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 38.86  E-value: 3.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145966853   336 KSILLLSGERGCGKSTLIANWVSNFQSKHPGVLMIpyfvgsTC-ESCDIMSVIHYFVMELQHRANGPRLEMDFLNedsnv 414
Cdd:pfam13401    5 AGILVLTGESGTGKTTLLRRLLEQLPEVRDSVVFV------DLpSGTSPKDLLRALLRALGLPLSGRLSKEELLA----- 73

                           90       100
                   ....*....|....*....|....*....
gi 145966853   415 lvfslLVEVFIAAISLKPCiLVLDGIEEL 443
Cdd:pfam13401   74 -----ALQQLLLALAVAVV-LIIDEAQHL 96
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 336-443 4.05e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 39.28  E-value: 4.05e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145966853    336 KSILLLSGERGCGKSTLIANWVSNFQSKHPGVLmipyfvgstcescdimsvihYFVMELQHRANGPRLEMDFLNEDSNVL 415
Cdd:smart00382    2 GEVILIVGPPGSGKTTLARALARELGPPGGGVI--------------------YIDGEDILEEVLDQLLLIIVGGKKASG 61

                            90       100
                    ....*....|....*....|....*....
gi 145966853    416 VFSLLVEVFIA-AISLKPCILVLDGIEEL 443
Cdd:smart00382   62 SGELRLRLALAlARKLKPDVLILDEITSL 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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