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Conserved domains on  [gi|51467992|ref|NP_001003872|]
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N-acetyltransferase ESCO2 [Danio rerio]

Protein Classification

ESCO family N-acetyltransferase( domain architecture ID 13315065)

ESCO family N-acetyltransferase contains a C2H2 zinc finger, is required for the establishment of sister chromatid cohesion, and may acetylate components of the cohesin complex; contains an N-terminal region with similarity to a partial 104 kDa microneme/rhoptry antigen domain; similar to Danio rerio N-acetyltransferase ESCO2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_13 pfam13880
ESCO1/2 acetyl-transferase;
537-605 1.60e-36

ESCO1/2 acetyl-transferase;


:

Pssm-ID: 464015  Cd Length: 69  Bit Score: 130.68  E-value: 1.60e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51467992   537 EKALCGVSRIWVFSLMRRKSVATRLLDTARNTFMYGSHLTKEEIAFSDPTPQGKLFATKYCQTPTFLVY 605
Cdd:pfam13880   1 VPAKCGISRIWVSPSHRRKGIATRLLDAARSNFIYGYILEKDEIAFSQPTESGKAFARKYFGTDDFLVY 69
zf-C2H2_3 pfam13878
zinc-finger of acetyl-transferase ESCO;
379-418 3.15e-16

zinc-finger of acetyl-transferase ESCO;


:

Pssm-ID: 464013  Cd Length: 40  Bit Score: 72.27  E-value: 3.15e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 51467992   379 QLIIDAGQKQFGATTCASCGMLYSTDSPEDNFQHTQFHQR 418
Cdd:pfam13878   1 QLILDLGQKSFGATQCKECGMVYNPGSPEDEKLHKKYHAR 40
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 3-305 3.76e-05

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.99  E-value: 3.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467992    3 SRKRKHGSPDAESNPSKKQITSLRSSPRRTTRQ----KENIPISLNSPQKIPSTPKKTQRAFLLESPPKRVSPRKAVLGA 78
Cdd:PTZ00449 528 EGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKpgpaKEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRPT 607

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467992   79 GTFYSKQKPLYLTPLERKVLKEAKSPPS-VTNKEPSRPPLTAANQVVKPAKKVQKKPRASAPQSNLKGYFTAKPKATKSS 157
Cdd:PTZ00449 608 RPKSPKLPELLDIPKSPKRPESPKSPKRpPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSK 687

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467992  158 SDKQTDQVLKSTMAPISFSSMKSKGKPKLVVGAAffnTGKKPTSmykKSAQNTKPK-PTYEKPSirkpvrEKELVTAPGQ 236
Cdd:PTZ00449 688 ETKTTVVLDESFESILKETLPETPGTPFTTPRPL---PPKLPRD---EEFPFEPIGdPDAEQPD------DIEFFTPPEE 755

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467992  237 RSpvrraVFLKKQPEVEVSHD-KRESTQAPmspqvlaDVHGITKELRVVLRRSVSPETGSQDAPSEADSV 305
Cdd:PTZ00449 756 ER-----TFFHETPADTPLPDiLAEEFKEE-------DIHAETGEPDEAMKRPDSPSEHEDKPPGDHPSL 813
 
Name Accession Description Interval E-value
Acetyltransf_13 pfam13880
ESCO1/2 acetyl-transferase;
537-605 1.60e-36

ESCO1/2 acetyl-transferase;


Pssm-ID: 464015  Cd Length: 69  Bit Score: 130.68  E-value: 1.60e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51467992   537 EKALCGVSRIWVFSLMRRKSVATRLLDTARNTFMYGSHLTKEEIAFSDPTPQGKLFATKYCQTPTFLVY 605
Cdd:pfam13880   1 VPAKCGISRIWVSPSHRRKGIATRLLDAARSNFIYGYILEKDEIAFSQPTESGKAFARKYFGTDDFLVY 69
zf-C2H2_3 pfam13878
zinc-finger of acetyl-transferase ESCO;
379-418 3.15e-16

zinc-finger of acetyl-transferase ESCO;


Pssm-ID: 464013  Cd Length: 40  Bit Score: 72.27  E-value: 3.15e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 51467992   379 QLIIDAGQKQFGATTCASCGMLYSTDSPEDNFQHTQFHQR 418
Cdd:pfam13878   1 QLILDLGQKSFGATQCKECGMVYNPGSPEDEKLHKKYHAR 40
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 3-305 3.76e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.99  E-value: 3.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467992    3 SRKRKHGSPDAESNPSKKQITSLRSSPRRTTRQ----KENIPISLNSPQKIPSTPKKTQRAFLLESPPKRVSPRKAVLGA 78
Cdd:PTZ00449 528 EGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKpgpaKEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRPT 607

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467992   79 GTFYSKQKPLYLTPLERKVLKEAKSPPS-VTNKEPSRPPLTAANQVVKPAKKVQKKPRASAPQSNLKGYFTAKPKATKSS 157
Cdd:PTZ00449 608 RPKSPKLPELLDIPKSPKRPESPKSPKRpPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSK 687

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467992  158 SDKQTDQVLKSTMAPISFSSMKSKGKPKLVVGAAffnTGKKPTSmykKSAQNTKPK-PTYEKPSirkpvrEKELVTAPGQ 236
Cdd:PTZ00449 688 ETKTTVVLDESFESILKETLPETPGTPFTTPRPL---PPKLPRD---EEFPFEPIGdPDAEQPD------DIEFFTPPEE 755

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467992  237 RSpvrraVFLKKQPEVEVSHD-KRESTQAPmspqvlaDVHGITKELRVVLRRSVSPETGSQDAPSEADSV 305
Cdd:PTZ00449 756 ER-----TFFHETPADTPLPDiLAEEFKEE-------DIHAETGEPDEAMKRPDSPSEHEDKPPGDHPSL 813
 
Name Accession Description Interval E-value
Acetyltransf_13 pfam13880
ESCO1/2 acetyl-transferase;
537-605 1.60e-36

ESCO1/2 acetyl-transferase;


Pssm-ID: 464015  Cd Length: 69  Bit Score: 130.68  E-value: 1.60e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51467992   537 EKALCGVSRIWVFSLMRRKSVATRLLDTARNTFMYGSHLTKEEIAFSDPTPQGKLFATKYCQTPTFLVY 605
Cdd:pfam13880   1 VPAKCGISRIWVSPSHRRKGIATRLLDAARSNFIYGYILEKDEIAFSQPTESGKAFARKYFGTDDFLVY 69
zf-C2H2_3 pfam13878
zinc-finger of acetyl-transferase ESCO;
379-418 3.15e-16

zinc-finger of acetyl-transferase ESCO;


Pssm-ID: 464013  Cd Length: 40  Bit Score: 72.27  E-value: 3.15e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 51467992   379 QLIIDAGQKQFGATTCASCGMLYSTDSPEDNFQHTQFHQR 418
Cdd:pfam13878   1 QLILDLGQKSFGATQCKECGMVYNPGSPEDEKLHKKYHAR 40
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 3-305 3.76e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.99  E-value: 3.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467992    3 SRKRKHGSPDAESNPSKKQITSLRSSPRRTTRQ----KENIPISLNSPQKIPSTPKKTQRAFLLESPPKRVSPRKAVLGA 78
Cdd:PTZ00449 528 EGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKpgpaKEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRPT 607

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467992   79 GTFYSKQKPLYLTPLERKVLKEAKSPPS-VTNKEPSRPPLTAANQVVKPAKKVQKKPRASAPQSNLKGYFTAKPKATKSS 157
Cdd:PTZ00449 608 RPKSPKLPELLDIPKSPKRPESPKSPKRpPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSK 687

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467992  158 SDKQTDQVLKSTMAPISFSSMKSKGKPKLVVGAAffnTGKKPTSmykKSAQNTKPK-PTYEKPSirkpvrEKELVTAPGQ 236
Cdd:PTZ00449 688 ETKTTVVLDESFESILKETLPETPGTPFTTPRPL---PPKLPRD---EEFPFEPIGdPDAEQPD------DIEFFTPPEE 755

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467992  237 RSpvrraVFLKKQPEVEVSHD-KRESTQAPmspqvlaDVHGITKELRVVLRRSVSPETGSQDAPSEADSV 305
Cdd:PTZ00449 756 ER-----TFFHETPADTPLPDiLAEEFKEE-------DIHAETGEPDEAMKRPDSPSEHEDKPPGDHPSL 813
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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