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Conserved domains on  [gi|51467942|ref|NP_001003853|]
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beta-galactoside alpha-2,6-sialyltransferase 1 [Danio rerio]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 206-471 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467713  Cd Length: 266  Bit Score: 556.24  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 206 GPEILCEIKEKVQVTTLTPDMEPFSGFPWGSQLPPRQITSDVGPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPT 285
Cdd:cd23985   1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 286 AGFETDVGSKTTVRLINSQLMASEDHHFLSSSLYSAGILVSWDPSPYSSDLWEWFNKTDYPIFKQYQRYRRLHPQQPFYI 365
Cdd:cd23985  81 AGFQQDVGTKTTIRLINSQLVTTEKHKFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 366 VHPRMEWQLWQRIQDNMGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTELCHYYQRFSDAACTLGAYHPLLYE 445
Cdd:cd23985 161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                       250       260
                ....*....|....*....|....*.
gi 51467942 446 KNLVKRMNQGSDRDIYTLGRVTLPGF 471
Cdd:cd23985 241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
 
Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 206-471 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 556.24  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 206 GPEILCEIKEKVQVTTLTPDMEPFSGFPWGSQLPPRQITSDVGPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPT 285
Cdd:cd23985   1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 286 AGFETDVGSKTTVRLINSQLMASEDHHFLSSSLYSAGILVSWDPSPYSSDLWEWFNKTDYPIFKQYQRYRRLHPQQPFYI 365
Cdd:cd23985  81 AGFQQDVGTKTTIRLINSQLVTTEKHKFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 366 VHPRMEWQLWQRIQDNMGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTELCHYYQRFSDAACTLGAYHPLLYE 445
Cdd:cd23985 161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                       250       260
                ....*....|....*....|....*.
gi 51467942 446 KNLVKRMNQGSDRDIYTLGRVTLPGF 471
Cdd:cd23985 241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 249-454 4.07e-33

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 126.18  E-value: 4.07e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942   249 PFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLIN--SqLMASEDHHFLSSSLYSAGIL-V 325
Cdd:pfam00777  42 RCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeS-AIDSKYGNLGFSHPRDPFVEfV 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942   326 SwdpSPYSSDLWEW-----FNKTDYPIFKQYQRYRRLH-PQQP--FYIVHPR-MEW--QLWQRiqdnmGEAIQKNPPSSG 394
Cdd:pfam00777 121 L---VPFKGRDLLWlpaflTKGNVSRSLRVLYTLKEVKiPVDPdkVLFLHPDfLRYvaNFWLR-----SHGLKGRRPSTG 192

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 51467942   395 LLGTVLMMSLCEVVHVYEFLP--SRRKTELcHYYQRFSDAACTLGAYHPLLYEKNLVKRMNQ 454
Cdd:pfam00777 193 LLMLSLALHLCDEVSLYGFGPflDSRGNSH-HYYDNVLMKKGGFYGVHDMPFEFKLLQKLHK 253
 
Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 206-471 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 556.24  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 206 GPEILCEIKEKVQVTTLTPDMEPFSGFPWGSQLPPRQITSDVGPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPT 285
Cdd:cd23985   1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 286 AGFETDVGSKTTVRLINSQLMASEDHHFLSSSLYSAGILVSWDPSPYSSDLWEWFNKTDYPIFKQYQRYRRLHPQQPFYI 365
Cdd:cd23985  81 AGFQQDVGTKTTIRLINSQLVTTEKHKFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 366 VHPRMEWQLWQRIQDNMGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTELCHYYQRFSDAACTLGAYHPLLYE 445
Cdd:cd23985 161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                       250       260
                ....*....|....*....|....*.
gi 51467942 446 KNLVKRMNQGSDRDIYTLGRVTLPGF 471
Cdd:cd23985 241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 203-471 3.12e-139

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 401.14  E-value: 3.12e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 203 KLSGPEILCEIKEKVQVTTLTPDMEPFSGFPWgSQLPPRQITSDVGP--FKTCAVVSSAGSLKNSGLGKEIDSHDAVIRF 280
Cdd:cd23986   1 KLSRQELLCELKKRVQVRTLDGKEAPFSALGW-EKYVPKIPLSKLHLrgFRSCAVVTSAGAILNSSLGKEIDSHDAVLRF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 281 NAAPTAGFETDVGSKTTVRLINSQLMASEDHHFLSSSLYSAGILVSWDPSPYSSDLWEWFNKTDYPIFKQYQRYRRLHPQ 360
Cdd:cd23986  80 NSAPTRGYEKDVGNKTTIRIINSQILTNPNHHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPN 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 361 QPFYIVHPRMEWQLWQRIQDNMGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTELCHYYQRFSDAACTLGAYH 440
Cdd:cd23986 160 QPFYILHPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYH 239

                       250       260       270
                ....*....|....*....|....*....|.
gi 51467942 441 PLLYEKNLVKRMNQGSDRDIYTLGRVTLPGF 471
Cdd:cd23986 240 PLLYEKLLIQRMNKGTEDDLYRKGKVILPGF 270
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 208-471 3.69e-134

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 388.17  E-value: 3.69e-134
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 208 EILCEIKEKVQVTTLTPDMEPFSGFPWGSQLPPRQITSDVGPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAG 287
Cdd:cd23968   3 DLLCRLKKAAPFSTLRKTTSPFKDLLSLRYPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 288 FETDVGSKTTVRLINSQLMASEDHHFLSSSLYSAGILVSWDPSPYSSDLWEWFNKTDYPIFKQYQRYRRLHPQQPFYIVH 367
Cdd:cd23968  83 FEKDVGSKTTLRLINSQILSKPEFNFLTDPLYRNVTLLVWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFYLID 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 368 PRMEWQLWQRIQDNMGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTELCHYYQRFSDAACTLGAYHPLLYEKN 447
Cdd:cd23968 163 PRFLWRLWDILQEYTPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDRCHYYDVEKDLACTLGAWHPLAAEKL 242

                       250       260
                ....*....|....*....|....
gi 51467942 448 LVKRMNQGSDRDIYTLGRVTLPGF 471
Cdd:cd23968 243 LVRHLNVGSDDDIFRKGRATLPGF 266
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 253-452 8.02e-46

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 158.29  E-value: 8.02e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 253 CAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQlmasedhhflSSSLYSAGILVSWDPSPY 332
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSK----------WAGFYLRGPRCGCHPLPL 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 333 SSD--LWEWFnkTDYPIFKQYQRYRRLHPQQPFYIVHPRME-WQLWQRIQDNMG--EAIQKNPPSSGLLGTVLMMSLCEV 407
Cdd:cd19952  71 EEEvvLILSR--AAAADFKRLKRRKKRHDNAVLLLTDPAPDlLSYVRKRLEKLGlkSFFGGNAPSSGLLAVLLALQLCDS 148

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 51467942 408 VHVYEFLPSRRKTEL--CHYYQRFSDAACTlgAYHPLLYEKNLVKRM 452
Cdd:cd19952 149 VDLYGFGVDSGHAPKvpYHYYDLVEAEEGT--AVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 249-454 4.07e-33

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 126.18  E-value: 4.07e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942   249 PFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLIN--SqLMASEDHHFLSSSLYSAGIL-V 325
Cdd:pfam00777  42 RCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeS-AIDSKYGNLGFSHPRDPFVEfV 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942   326 SwdpSPYSSDLWEW-----FNKTDYPIFKQYQRYRRLH-PQQP--FYIVHPR-MEW--QLWQRiqdnmGEAIQKNPPSSG 394
Cdd:pfam00777 121 L---VPFKGRDLLWlpaflTKGNVSRSLRVLYTLKEVKiPVDPdkVLFLHPDfLRYvaNFWLR-----SHGLKGRRPSTG 192

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 51467942   395 LLGTVLMMSLCEVVHVYEFLP--SRRKTELcHYYQRFSDAACTLGAYHPLLYEKNLVKRMNQ 454
Cdd:pfam00777 193 LLMLSLALHLCDEVSLYGFGPflDSRGNSH-HYYDNVLMKKGGFYGVHDMPFEFKLLQKLHK 253
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 248-430 7.25e-30

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 117.75  E-value: 7.25e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 248 GPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKT--------TVRLINSQLMASEDH-HFLSS-S 317
Cdd:cd23963  61 KRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsILKRRYNSLKKNRDRdKFLNRlK 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 318 LYSAGILVswdpspYSSDLWEWFNKtdyPIFKQYQRYR-RLHPQQPFYI--VHPRMEWQLWQRIQDnmgeaiqKNPPSSG 394
Cdd:cd23963 141 EYNGSILW------YPKFSFKSSTN---LLLKAARALKkNGLNLTVVYSnpEHFLAVQKFWKRRGL-------EKRPSTG 204

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 51467942 395 LLGTVLMMSLCEVVHVYEFLP----SRRKTELCHYYQRFS 430
Cdd:cd23963 205 LYLVSLALTFCDEIHLYGFWPfptdPNGRPVPYHYYDDLS 244
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 251-440 4.26e-29

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 114.26  E-value: 4.26e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 251 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLI---NSQLMASeDHHFLSSSLYSAGILVSW 327
Cdd:cd23965   2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVshsSLPRLLR-NAILLLAGTRAPTVVVFW 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 328 DPSPYssdlwewFNKTDYPIFKQYQRYRRLHPQQPFYIVHPRMEWQLWQRIQDNMGeaiqKNPPSSGL-LGT-----VLM 401
Cdd:cd23965  81 GPETK-------MNKDGAGKYNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETG----KSRIKSGTwLSTgwftmLLA 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 51467942 402 MSLCEVVHVYEFLPS------RRKTELCHYYQRFSDAACTLGAYH 440
Cdd:cd23965 150 LDVCDEIKVYGMVPEnycrehPNSKVPYHYYEPGGLKECTYYNYH 194
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 251-452 2.70e-25

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 102.82  E-value: 2.70e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 251 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLI-------NSQLMASEDHHFlssslysagI 323
Cdd:cd23982   3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFypesaqfDPGIENDPDTLL---------V 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 324 LVSWDPSPYssdLW--EWFNKTDYP---IFKQYQRYRRLHPQQpFYIVHPRMEWQLWQRIQDNMGEAIQKNPPSSGLLGT 398
Cdd:cd23982  74 LVPFKPLDF---YWlyEILSNEKRVrkgFWKQPPRIWDANPKQ-IRILNPYYTYVAATKLLQVPGQRKKKQKPTTGLLAI 149

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 51467942 399 VLMMSLCEVVHVYEF-LP-SRRKTELCHYYQRFSDAAcTLGAYHPLLYEKNLVKRM 452
Cdd:cd23982 150 TLALHLCDEVHIAGFgYPdNGNSNQPIHYYNQITLKS-MANSGHNLNAEAQAIQRL 204
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 251-452 4.40e-24

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 99.67  E-value: 4.40e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 251 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLI--NSQLMASEDHHflSSSLYsagILVswd 328
Cdd:cd23967   3 RRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFypESAFRDPEEYD--SDWLL---VLV--- 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 329 psPY-SSDL--------------WEWFNKTDYPIF-KQYQRYRRLHPQQP----FYIVHPRMewqlwqriQDNMGeaiqK 388
Cdd:cd23967  75 --PFkSMDLlwlqavikgkkpngKGGFWKKIATSVpKPPKKIRILNPYILqeaaFDLIGLPM--------NGKQG----K 140

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 51467942 389 NPPSSGLLGTVLMMSLCEVVHV--YEFLPSRRKTELcHYYQRFSDAACTLGAYHPLLYEKNLVKRM 452
Cdd:cd23967 141 NVPTTGIIAIVMALHYCDEVDIagFGYDPSDPNAPL-HYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 239-413 5.40e-21

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 92.73  E-value: 5.40e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 239 PPRQITSDVGPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTvrlinsqlmasedHHFL---S 315
Cdd:cd23966  66 ENPYRTRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTT-------------HHFMypeS 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 316 SSLYSAG---ILVSWDPspysSDLwEWFNK--TDYPIFKQYQRYRR-----------LHPQQpFYIVHPRmeWqlwqriq 379
Cdd:cd23966 133 AVDLDPGvhlVLVPFKV----LDL-QWLISalTTGEITRTYTPVKRfikadkdkvlvINPAF-IKYVHDN--W------- 197

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 51467942 380 dnmgeaIQKNP--PSSGLLGTVLMMSLCEVVHVYEF 413
Cdd:cd23966 198 ------TEHHGryPSTGFLALIFALHICDEVSVFGF 227
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 251-452 3.99e-20

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 88.64  E-value: 3.99e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 251 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQLMASEDHHFLSSSLYSAGILVSWD-- 328
Cdd:cd23983   3 RRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVDfa 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 329 ---------PSPYSSDLWEWFNKTDyPIFKQYQRYRRLHPQqpfyIVH-----------PRMEWQLWqriqdnmgeaiQK 388
Cdd:cd23983  83 wlkamvkkePLSFWSRLFFWKEVAD-SIPLKPSQFRILNPL----IIKetaldilqypePQSRLWGW-----------DK 146

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 51467942 389 NPPSSGLLGTVLMMSLCEVVHVYEF---LpSRRKTELcHYYQRFSDAACTLGAYHPLLYEKNLVKRM 452
Cdd:cd23983 147 NVPTLGVTAVVLATHLCDEVSLAGFgydL-SQPHAPL-HYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 251-411 8.03e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 87.99  E-value: 8.03e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 251 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQ---LMASEDHHFLSSSlySAGILVSW 327
Cdd:cd23977   2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTsvpLLLRNQGYFFQQS--RDTKYVIW 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 328 DPSPYSSDLwewfnkTDYPIFKQYQRYRRLHPQQPFYIVHPRMEWQLWQRIQDNMGEAIQKNPP--SSGLLGTVLMMSLC 405
Cdd:cd23977  80 GPERNMDRD------GGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSflSTGWFTMILALELC 153


                ....*.
gi 51467942 406 EVVHVY 411
Cdd:cd23977 154 EEILVY 159
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 252-426 2.40e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 88.08  E-value: 2.40e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 252 TCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTT--VRLINSQLMASEDHHFLSSSL-YsagILVSWD 328
Cdd:cd23964  84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSfyTFFPESLHNSLLKHVPQDKDTkY---LFIPFK 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 329 PSPYSSdLWEWFNKTDYPIFKQ----YQRYRRLHPQ-QPFYIVHP---R-MEWQlWQRIQDNmgeaiqkNPPSSGLLGTV 399
Cdd:cd23964 161 IRDYDY-LDAVLSGKPVPDGCDkgkrPPPLFGPKLNaTNVRLLHPdfiRyLFNR-WLNSSTS-------YRPTTGALMLL 231

                       170       180
                ....*....|....*....|....*..
gi 51467942 400 LMMSLCEVVHVYEFLPSRRKTElcHYY 426
Cdd:cd23964 232 TALHTCDQVSVYGFGYDPRFSL--HYY 256
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 250-426 1.08e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 85.93  E-value: 1.08e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 250 FKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQLMASEDHHFLSSSLYSA-------- 321
Cdd:cd23969  64 FRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPHAYGDLVNATDKEKfverlrql 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 322 --GILvsWDP---SPYSSDLWEWFNKTdypIFKQYQRYRRLHPQqpfyivhPRMEwQLWQRIQDNMGEAIQKnpPSSGLL 396
Cdd:cd23969 144 gdSIL--WIPafvSKGGEEHVQWTNEI---ILKHKLNVKTAYPP-------LRLN-HAIRGYWLTTKFRIKR--PSTGLL 208

                       170       180       190
                ....*....|....*....|....*....|....
gi 51467942 397 GTVLMMSLCEVVHVYEFLP---SRRKTEL-CHYY 426
Cdd:cd23969 209 MYTLATRFCDEIHLYGFYPfseDGNGRAVkYHYY 242
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 249-452 4.04e-18

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 82.87  E-value: 4.04e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 249 PFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQLMASEDHHFLSSSLYsagILVSWD 328
Cdd:cd23984   1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTV---VLIPFK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 329 PspysSDL---WE------------WFNKTDYPIFKQYQrYRRLHpqqPFYIVHPRMEWqlwqrIQDNMGEAIQKNP--P 391
Cdd:cd23984  78 P----HDLrwlLDllmgkkvsakgfWKKPALNLIYKPNQ-IRILN---PFILRIAAYEL-----LHFPKRFPKEKKPkhP 144

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51467942 392 SSGLLGTVLMMSLCEVVHV----YEFlpSRRKTELcHYYQRFSDAACTLGAYHPLLYEKNLVKRM 452
Cdd:cd23984 145 TTGIIAITLALHICNEVHIagfkYDF--SNLNSTL-HYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 253-451 2.75e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 81.05  E-value: 2.75e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 253 CAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLIN----SQLMASEDhHFLssSLYSAGILVSWD 328
Cdd:cd23978   4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAhssvYRVLRRPQ-EFL--NRTPETTLIFWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 329 PspyssdlwewFNKTDYP----IFKQYQRYRRLHPQQPFYIVHPRMEWQLWQRIQDNMGEAIQKNPP--SSGLLGTVLMM 402
Cdd:cd23978  81 P----------PNKMQKDgksnLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSwlSTGWFTMVIAV 150

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51467942 403 SLCEVVHVYEFLP-------SRRKTELCHYYQRFSDAACTL---------GAYHPLLYEKNLVKR 451
Cdd:cd23978 151 ELCDNVHVYGMVPpnycskrPTPKKMPYHYYEPKGPDECVTyiqnehgrrGNHHRFITEKRVFAR 215
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 251-413 2.94e-17

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 81.85  E-value: 2.94e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 251 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTvrlinsqlmasedHHFL-SSSLYSAGILVSWDP 329
Cdd:cd23980  82 RRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTT-------------HHFVyPESFRELAQNVSMIL 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 330 SPYSSDLWEW---------FNKTDYPIfkqyqrYRRLHPQQP-FYIVHPRMEWQLWQRIQDNMGEAiqknpPSSGLLGTV 399
Cdd:cd23980 149 VPFKTLDLEWvisatttgtISHTYVPV------PRKIKVKKEkILIYHPAFIKYVFDRWLQGHGRY-----PSTGILSVI 217

                       170
                ....*....|....
gi 51467942 400 LMMSLCEVVHVYEF 413
Cdd:cd23980 218 FSLHVCDEVDLYGF 231
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 250-415 8.66e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 77.69  E-value: 8.66e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 250 FKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQLMA--------SEDHHFLSSSLYSA 321
Cdd:cd23988  64 FKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQrafggfrnESDREKFVHRLSML 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 322 GILVSWDPS---PYSSDLWEWFNKTdypIFKQYQRYRRLHPQqpFYIVHPRMEWQLWQRIQdnmgeaIQKnpPSSGLLGT 398
Cdd:cd23988 144 NDSVLWIPAfmvKGGEKHVEWVNAL---ILKNKLKVRTAYPS--LRLIHAVRGYWLTNKVN------IKR--PSTGLLMY 210

                       170
                ....*....|....*..
gi 51467942 399 VLMMSLCEVVHVYEFLP 415
Cdd:cd23988 211 TLATRFCDEIHLYGFWP 227
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 212-415 1.45e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 76.53  E-value: 1.45e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 212 EIKEKVQVTTLTPDMEPFSgFPWGSqlpprqitsdvGPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAgFETD 291
Cdd:cd23971  38 ERKKTITVNEKLFSMLPKE-SPFSN-----------KPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKD 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 292 VGSKTTVRLIN-SQLMasEDHHFLssslysagilvSWDPSPYSSDLWEWFNKTDY-PIFkQYQR-----YRRLH------ 358
Cdd:cd23971 105 VGSKTNLVTANpSILR--EKFHNL-----------KKRRRPFVERMKVYGNALLLlPAF-SYTSntepsLRALYtledfg 170

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 51467942 359 -PQQPFYIvHPRMEWQL---WQriqdnmGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLP 415
Cdd:cd23971 171 sPQKVLFF-NPEYLRNLsryWK------SKGLKARRLSTGLMLVSAALELCENVHLYGFWP 224
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 212-426 1.71e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 76.72  E-value: 1.71e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 212 EIKEKVQVTTLTPDMEPFSGFPwgsqlpprqitsdvgpFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAG-FET 290
Cdd:cd23991  42 KILITENIFRMFPKSQPFRGYP----------------YKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISK 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 291 DVGSKTTVRLINSQLMA---SEDHH----FLSS-SLYSAGILVSwdPS-PYSSDLWEWFnKTDYPI--FKQYQRYRRLHP 359
Cdd:cd23991 106 DVGSKTNLVTANPSIISikyAKLNErrkpFLETvSVYGDAFLLL--PAfSYRSNTALSF-KVYYTLedFKAKQKVIFFHP 182

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 51467942 360 QqpfYIVHPRMEWQlwqriqdnmGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTE----LCHYY 426
Cdd:cd23991 183 I---YLKHLAQFWR---------SKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEgkpiSHHYY 241
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 250-452 4.91e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 75.51  E-value: 4.91e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 250 FKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLIN--------SQLMASEDHHFLSSSLYSA 321
Cdd:cd23970  68 YNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNpsilekyyNNLLTIQDRNNFFLSLKKL 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 322 GILVSWDPS---PYSSD--------LWEWFNKTD----YP--IFKQYQRYRRLHPQQPfyivhprmewqlwQRIqdnmge 384
Cdd:cd23970 148 DGAILWIPAfffHTSATvtrtlvdfFVEHRGQLKvqlaWPgnIMQHVNRYWKTKHLSP-------------KRL------ 208

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 51467942 385 aiqknppSSGLLGTVLMMSLCEVVHVYEFLP---SRRKTELC-HYYQRFsDAACTLG--AYHPLLYEKNLVKRM 452
Cdd:cd23970 209 -------STGILMYTLASAICEEIHLYGFWPfgfDPTGTPLPyHYYDKK-GTKFTTKwqESHQLPAEFVLLYKM 274
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 251-454 5.21e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 74.52  E-value: 5.21e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 251 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLI---NSQLMASEDHHFLSSSlySAGILVSW 327
Cdd:cd23976  16 KSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIahsSIQRILRNRNELLNVS--QGTVFIFW 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 328 DPSPYSsdlwewfnKTDYP--IFKQYQRYRRLHPQQPFYIVHPRMEWQLWQRIQDNMGE--AIQKNPPSSGLLGTVLMMS 403
Cdd:cd23976  94 GPSNYM--------RRDGKglVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKdrKISNTWLSTGWFTMIIALE 165

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 51467942 404 LCEVVHVY-----EFLPSRRKTEL-CHYYQRFSDAACTL---------GAYHPLLYEKNLVKRMNQ 454
Cdd:cd23976 166 LCDRINVYgmvppDFCRDPNHPSVpYHYYEPSGPDECTMyishergrkGSHHRFITEKRVFANWAR 231
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 250-426 8.13e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 74.59  E-value: 8.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 250 FKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQLM--ASED-------HHFLsSSLYS 320
Cdd:cd23987  64 FKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVqrAFEDlvnetwkEKFL-QRLQS 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 321 AGILVSWDPSPYS---SDLWEWFNKTdypIFKQYQRYRRLHPQqpFYIVHPRMEWQLWQRIQdnmgeaIQKnpPSSGLLG 397
Cdd:cd23987 143 LNGSILWIPAFMAkggEERVEWVNDL---ILKHHINVRTAYPS--LRLLHAVRGYWLTNKVH------IKR--PTTGLLM 209

                       170       180       190
                ....*....|....*....|....*....|...
gi 51467942 398 TVLMMSLCEVVHVYEFLPSRR----KTELCHYY 426
Cdd:cd23987 210 YTLATRFCNRIHLYGFWPFPRdqnqNPVKYHYY 242
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 252-452 3.84e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 73.25  E-value: 3.84e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 252 TCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSqlmasedhHFLSSSLYSAG--------- 322
Cdd:cd23973  85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTA--------HSITSSLMILQkrgfknipq 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 323 ------ILVSWDPSPYssdlwEWF-----NKT--DYPIFKQYQRYR---RLHPQQpFYIVHP---RMEWQLWQRIQDNMG 383
Cdd:cd23973 157 dkdikyILFPEGPRDY-----QWLeallkNKTipSGAYYGRRPRSYfsgDFTEDK-YLVLHPdflRYVKNRFLRSKTLKG 230

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51467942 384 EAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTELCHYYQRfSDAACTLGAYHPLLYEKNLVKRM 452
Cdd:cd23973 231 KYWAIYRPTTGAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDK-KKTKLVFYINHDFRLEKKLWKRL 298
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 253-314 1.01e-12

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 68.36  E-value: 1.01e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 51467942 253 CAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTvrlinsqlmasedHHFL 314
Cdd:cd23979  83 CAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTT-------------HHFM 131
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 250-413 2.59e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 67.17  E-value: 2.59e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 250 FKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAP-TAGFETDVGSKTTVRLINSQLMASEDHHF---------LSSSLY 319
Cdd:cd23990  64 FKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTINPSIITERFHKLekwrrpfyeVLQVYE 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 320 SAGILVswdPSPYSSdlwewfNKTDYPIFKQYQrYRRLHPQQPFYIVHPRMEWQLwQRIQDNMGeaIQKNPPSSGLLGTV 399
Cdd:cd23990 144 NASVVL---PAFYNT------RNTDVSIRVKYV-LDDFESQQAVYYFHPQYLLNV-SRFWLRQG--VRAKRISSGLMLVT 210

                       170
                ....*....|....
gi 51467942 400 LMMSLCEVVHVYEF 413
Cdd:cd23990 211 AALELCEEVHLYGF 224
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 251-300 2.86e-12

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 65.71  E-value: 2.86e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 51467942 251 KTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRL 300
Cdd:cd23981   3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRI 52
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 220-426 6.68e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 66.01  E-value: 6.68e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 220 TTLTPDMEPFSGFPwgsQLPPRQItsdvgPFKTCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAP-TAGFETDVGSKTTV 298
Cdd:cd23989  41 HSHTVDNETYSLFP---QDTPLQL-----PLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQL 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 299 RLINSQLMASEDHHFLSSSLYSAGILVSWDPSPYSSDLWEWFNKTDyPIFKQYQRYRRLHPQQPFYIVHP---RMEWQLW 375
Cdd:cd23989 113 VTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTD-PSLRVYYTLADVGANQTVLFANPnflRNVGKFW 191

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 51467942 376 QriqdnmGEAIQKNPPSSGLLGTVLMMSLCEVVHVYEFLPSR----RKTELCHYY 426
Cdd:cd23989 192 K------SKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSvdldERTISHHYY 240
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 253-297 1.94e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 64.77  E-value: 1.94e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 51467942 253 CAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTT 297
Cdd:cd23974  87 CAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTS 131
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 230-453 3.38e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 64.07  E-value: 3.38e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 230 SGFPWGSQLPPRQITsdvgpfktCAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKT-----TVRLINSQ 304
Cdd:cd23972  70 AKLFFPRDTPGKCIR--------CAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTsfygfTVNTMKNS 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 305 LMASEDHHFLSSS------------------LYSAGILVSwdPSPYSSDlwewfnKTDypifkQYQRYRRLHPQ-QPFYI 365
Cdd:cd23972 142 LISYWNLGFTRTPqgqdlqyifipsdirdyvMLRSAILGV--PVPEGLD------KGD-----RPHKYFGPEASaKKFKL 208

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 366 VHPRMEWQLWQR------IQDNMGEAIQknpPSSGLLGTVLMMSLCEVVHVYEFLPSRRKTELCHYYQRfSDAACTLGAY 439
Cdd:cd23972 209 LHPDFISYLTDRflksklLNTHYGHLYM---PSTGALMLLTALHTCDQVSAYGFITSNYWKFSDHYYER-KKKPLVFYAN 284

                       250
                ....*....|....
gi 51467942 440 HPLLYEKNLVKRMN 453
Cdd:cd23972 285 HDMLLEAALWRRLH 298
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 253-411 1.39e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 61.10  E-value: 1.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 253 CAVVSSAGSLKNSGLGKEIDSHDAVIRFNAAPTAGFETDVGSKTTVRLINSQ---LMASEDHHFLSSSlySAGILVSWDP 329
Cdd:cd23975   4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTsvpLLLKNPDYFFKET--NETIYVIWGP 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51467942 330 spyssdLWEWFNKTDYPIFKQYQRYRRLHPQQPFYI-VHPRMEWQLWQRIQDNMGEAIQKNP-PSSGLLGTVLMMSLCEV 407
Cdd:cd23975  82 ------FRNMRKDGKGIVYNMLKKAVESYPQAKIYVtTEKRMSYCDTVFKKETGKDRVQSGSyLSTGWFTLILAMDACYG 155


                ....
gi 51467942 408 VHVY 411
Cdd:cd23975 156 IHVY 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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